Research Topics
Species | F W UnverzagtSummaryAffiliation: Indiana University Country: USA Publications
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Publications
ACTIVE cognitive training and rates of incident dementiaFrederick W Unverzagt
Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
J Int Neuropsychol Soc 18:669-77. 2012..Longer follow-up or enhanced training may be needed to fully explore the preventive capacity of cognitive training in forestalling onset of dementia...- The ACTIVE cognitive training trial and predicted medical expendituresFredric D Wolinsky
Health Services Research, Iowa City Veterans Affairs Medical Center, Iowa City, Iowa, USA
BMC Health Serv Res 9:109. 2009..We evaluated the effects of the three cognitive training interventions (memory, reasoning, or speed of processing) in the ACTIVE study on changes in predicted medical care expenditures... 
Clinical utility of CERAD neuropsychological battery in elderly JamaicansF W Unverzagt
Department of Psychiatry, Indiana University School of Medicine, Indianapolis, USA
J Int Neuropsychol Soc 5:255-9. 1999..This study is the first to demonstrate the clinical utility of the CERAD neuropsychological battery in the differential diagnosis of memory disorders of the aged in a non-North-American sample...- Mild cognitive dysfunction: an epidemiological perspective with an emphasis on African AmericansFrederick W Unverzagt
Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202, USA
J Geriatr Psychiatry Neurol 20:215-26. 2007..Factors contributing to this longitudinal variability in outcomes are reviewed, including the role of medical health factors. The review closes with suggestions for next steps in the epidemiological research of mild cognitive impairment... - Effect of memory impairment on training outcomes in ACTIVEFrederick W Unverzagt
Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
J Int Neuropsychol Soc 13:953-60. 2007..Memory function appears to mediate response to structured cognitive interventions in older adults... - The Indiana University telephone-based assessment of neuropsychological status: a new method for large scale neuropsychological assessmentFrederick W Unverzagt
Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
J Int Neuropsychol Soc 13:799-806. 2007..Results suggest that memory, attention, information processing speed, verbal fluency, and self-report of mood and memory can be measured reliably and precisely over the telephone... - Incidence and risk factors for cognitive impairment no dementia and mild cognitive impairment in African AmericansFrederick W Unverzagt
Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Alzheimer Dis Assoc Disord 25:4-10. 2011..Risk factors of age and education suggest exposures or mechanisms at both ends of the life span may be important variables in onset of CIND/MCI... - Vascular risk factors and cognitive impairment in a stroke-free cohortF W Unverzagt
Department of Psychiatry, Indiana University School of Medicine, 1111 W 10th Street, Suite PB 218A, Indianapolis, IN 46202, USA
Neurology 77:1729-36. 2011..To examine vascular risk factors, as measured by the Framingham Stroke Risk Profile (FSRP), to predict incident cognitive impairment in a large, national sample of black and white adults age 45 years and older... - Prevalence of cognitive impairment: data from the Indianapolis Study of Health and AgingF W Unverzagt
Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202 5266, USA
Neurology 57:1655-62. 2001..The epidemiology and natural history of cognitive impairment that is not dementia is important to the understanding of normal aging and dementia... - The Indiana Alzheimer Disease Center's Symposium on Mild Cognitive Impairment. Cognitive training in older adults: lessons from the ACTIVE StudyFrederick W Unverzagt
The Departments of Psychiatry, Indiana University School of Medicine, 1111 W 10th Street, Suite PB 218A, Indianapolis, IN 46202, USA
Curr Alzheimer Res 6:375-83. 2009..This finding suggests that MCI may interfere with a person's ability to benefit from some forms of cognitive enhancement. Limitations of ACTIVE and directions for future research are reviewed... - The development of a semi-structured home interview (CHIF) to directly assess function in cognitively impaired elderly people in two culturesH C Hendrie
Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Int Psychogeriatr 18:653-66. 2006..Assessing function is a crucial element in the diagnosis of dementia. This information is usually obtained from key informants. However, reliable informants are not always available... - Incidence of dementia and Alzheimer disease in 2 communities: Yoruba residing in Ibadan, Nigeria, and African Americans residing in Indianapolis, IndianaH C Hendrie
Department of Psychiatry, Indiana University School of Medicine, 541 Clinical Dr, Room 394A, Indianapolis, IN 46202, USA
JAMA 285:739-47. 2001..If populations were identified with significantly lower or higher incidence rates of AD, the search for risk factors in the genesis of AD could be greatly enhanced... - Use of anticholinergics and the risk of cognitive impairment in an African American populationN L Campbell
Wishard Health Services, Indianapolis, IN 46202 2872, USA
Neurology 75:152-9. 2010..Anticholinergic properties of certain medications often go unrecognized, and are frequently used by the elderly population. Few studies have yet defined the long-term impact of these medications on the incidence of cognitive impairment... - Preservation of cognitive function with antihypertensive medications: a longitudinal analysis of a community-based sample of African AmericansMichael D Murray
Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA
Arch Intern Med 162:2090-6. 2002..Corresponding analysis using blood pressure measurements on the subset of participants was inconclusive. CONCLUSION: Antihypertensive medication use is associated with preservation of cognitive function in older African American adults... - Cholesterol, APOE genotype, and Alzheimer disease: an epidemiologic study of Nigerian YorubaK Hall
Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Neurology 66:223-7. 2006..To examine the relationship between cholesterol and other lipids, APOE genotype, and risk of Alzheimer disease (AD) in a population-based study of elderly Yoruba living in Ibadan, Nigeria... - Low education and childhood rural residence: risk for Alzheimer's disease in African AmericansK S Hall
Department of Psychiatry, Indiana University School of Medicine, Indianapolis 46202 5111, USA
Neurology 54:95-9. 2000..To examine the relationship between level of education and childhood rural residence as possible risk factors for AD in African Americans in Indianapolis... - Cognitive function in breast cancer survivors compared to healthy age- and education-matched womenDiane Von Ah
Indiana University School of Nursing, Indianapolis, IN, USA
Clin Neuropsychol 23:661-74. 2009..Findings indicate that a sizeable percentage of breast cancer survivors have clinically significant cognitive impairment... - Effectiveness of collaborative care for older adults with Alzheimer disease in primary care: a randomized controlled trialChristopher M Callahan
Indiana University Center for Aging Research, Regenstrief Institute Inc, Indiana University School of Medicine, Indianapolis 46202, USA
JAMA 295:2148-57. 2006..Most older adults with dementia will be cared for by primary care physicians, but the primary care practice environment presents important challenges to providing quality care... - Trace element levels and cognitive function in rural elderly ChineseSujuan Gao
Department of Medicine, Indiana University School of Medicine, 410 West 10th Street, Suite 3000, Indianapolis, IN 46202, USA
J Gerontol A Biol Sci Med Sci 63:635-41. 2008..The relationship between trace elements measured in individual biological samples and cognitive function in an elderly population had not been investigated extensively... - Correlates of depressive symptoms in rural elderly ChineseSujuan Gao
Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
Int J Geriatr Psychiatry 24:1358-66. 2009..Late life depression has been studied in many populations around the world. However, findings on risk factors for late life depression have remained inconsistent... - Prevalence rates for dementia and Alzheimer's disease in African Americans: 1992 versus 2001Kathleen S Hall
Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA
Alzheimers Dement 5:227-33. 2009..This study compares age-specific and overall prevalence rates for dementia and Alzheimer's disease (AD) in two nonoverlapping, population-based cohorts of elderly African Americans in Indianapolis in 2001 and 1992... - Selenium level is associated with apoE epsilon4 in rural elderly ChineseSujuan Gao
Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202 2872, USA
Public Health Nutr 12:2371-6. 2009..The present paper examines the association between apoE genotype and Se levels in nail samples in a rural elderly Chinese cohort... - Risk of mortality for dementia in a developing country: the Yoruba in NigeriaAnthony J Perkins
Regenstrief Institute for Health Care, 1050 Wishard Boulevard, RG6, Indianapolis, IN 46202 2872, USA
Int J Geriatr Psychiatry 17:566-73. 2002..Limited data exist on the impact of dementia in developing nations, including its association with mortality... - Hypertension and cognitive decline in rural elderly ChineseSujuan Gao
Department of Medicine, Indiana University School of Medicine, 410 West 10th Street, Suite 3000, Indianapolis, IN 46202 2872, USA
J Am Geriatr Soc 57:1051-7. 2009..To examine the association between hypertension and cognitive decline in older adults... - Validation analysis of informant's ratings of cognitive function in African Americans and NigeriansJianzhao Shen
Department of Medicine, Indiana University School of Medicine, Indianapolis, 46202, USA
Int J Geriatr Psychiatry 21:618-25. 2006.... - Selenium level and cognitive function in rural elderly ChineseSujuan Gao
Department of Medicine, School of Medicine, Indiana University, Indianapolis, IN, USA
Am J Epidemiol 165:955-65. 2007..Results in this geographically stable cohort support the hypothesis that a lifelong low selenium level is associated with lower cognitive function... - Implementing a screening and diagnosis program for dementia in primary careMalaz Boustani
Indiana University Center for Aging Research, Indianapolis, USA
J Gen Intern Med 20:572-7. 2005..Primary care physicians are positioned to provide early recognition and treatment of dementia. We evaluated the feasibility and utility of a comprehensive screening and diagnosis program for dementia in primary care... - Accelerated weight loss and incident dementia in an elderly African-American cohortSujuan Gao
Department of Medicine, School of Medicine, Indiana University, Indianapolis, Indiana, USA
J Am Geriatr Soc 59:18-25. 2011..To examine the association between changes in body mass index (BMI), dementia, and mild cognitive impairment (MCI)... - Association of apolipoprotein E genotype and Alzheimer disease in African AmericansJill R Murrell
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, USA
Arch Neurol 63:431-4. 2006..Identification of genetic risk factors in African Americans is essential for understanding the etiology of AD... - Measuring primary care patients' attitudes about dementia screeningMalaz Boustani
Indiana University Center for Aging Research, Indianapolis, IN, USA
Int J Geriatr Psychiatry 23:812-20. 2008..To develop a questionnaire that will capture patients' attitudes about dementia screening in primary care... - An updated version of the Weigl discriminates adults with dementia from those with mild impairment and healthy controlsLeigh J Beglinger
Department of Psychiatry, University of Iowa College of Medicine, MEB 1 321, Iowa City, IA 52242 1000, USA
Arch Clin Neuropsychol 23:149-56. 2008..The new measure discriminated well between healthy controls and older adults with either cognitive impairment without dementia, or dementia. The Weigl-R may be a useful adjunct to brief dementia batteries but requires further validation... - The tauopathy associated with mutation +3 in intron 10 of Tau: characterization of the MSTD familySalvatore Spina
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Brain 131:72-89. 2008..This multidisciplinary study provides a comprehensive description of the natural history of disease in one of the largest known families with FTDP-17T... - Selecting pre-screening items for early intervention trials of dementia--a case studyLang Li
Division of Biostatistics, Indiana University School of Medicine, 1050 Wishard Boulevard, RG4, Indianapolis, IN 46202, USA
Stat Med 23:271-83. 2004..Using the boosting option for decision trees did not substantially improve the performance. We recommend that for each situation, different methods of classification should be attempted to obtain optimal results for a given purpose... - Ectopic white matter neurons, a developmental abnormality that may be caused by the PSEN1 S169L mutation in a case of familial AD with myoclonus and seizuresM Takao
Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis 46202, USA
J Neuropathol Exp Neurol 60:1137-52. 2001..We hypothesize that the PSEN1 mutation may have a causal relationship with an abnormality in neuronal development... - The effects of the ACTIVE cognitive training trial on clinically relevant declines in health-related quality of lifeFredric D Wolinsky
Department of Health Management and Policy, College of Public Health, University of Iowa, 200 Hawkins Drive, E205 General Hospital, Iowa City, IA 52242, USA
J Gerontol B Psychol Sci Soc Sci 61:S281-7. 2006..In this article, we evaluate ACTIVE's ability to avoid extensive decline in health-related quality of life (HRQoL)... - Six-item screener to identify cognitive impairment among potential subjects for clinical researchChristopher M Callahan
Indiana University Center for Aging Research, Indianapolis 46202, USA
Med Care 40:771-81. 2002..To design a brief cognitive screener with acceptable sensitivity and specificity for identifying subjects with cognitive impairment... - Changes in everyday function in individuals with psychometrically defined mild cognitive impairment in the Advanced Cognitive Training for Independent and Vital Elderly StudyVirginia G Wadley
Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
J Am Geriatr Soc 55:1192-8. 2007..To examine trajectories of change in everyday function for individuals with cognitive deficits suggestive of mild cognitive impairment (MCI)... - Effects of cognitive training interventions with older adults: a randomized controlled trialKarlene Ball
Department of Psychology, University of Alabama at Birmingham, 35294 2100, USA
JAMA 288:2271-81. 2002..However, few studies have addressed whether improving cognitive functions might have short- or long-term effects on activities related to living independently... - Categorization and recognition performance of a memory-impaired group: evidence for single-system modelsSafa R Zaki
Department of Psychology, Indiana University, Bloomington, USA
J Int Neuropsychol Soc 9:394-406. 2003..The results are interpreted as support for a single-system framework in which categorization and recognition depend on one representational system... - Cognitive status, stroke symptom reports, and modifiable risk factors among individuals with no diagnosis of stroke or transient ischemic attack in the REasons for Geographic and Racial Differences in Stroke (REGARDS) StudyVirginia G Wadley
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 2041, USA
Stroke 38:1143-7. 2007..This study evaluates relationships among cognitive status, stroke symptom reports, and cardiovascular and behavioral factors... - The Stick Design test: a new measure of visuoconstructional abilityOlusegun Baiyewu
Department of Psychiatry, College of Medicine, University of Ibadan, Ibadan, Nigeria
J Int Neuropsychol Soc 11:598-605. 2005..We conclude that Stick Design is a reasonable test of visuoconstructional ability in older cohorts with very limited educational exposure and literacy... - Long-term effects of cognitive training on everyday functional outcomes in older adultsSherry L Willis
Department of Human Development and Family Studies, Pennsylvania State University, State College, PA 16801
JAMA 296:2805-14. 2006..Cognitive training has been shown to improve cognitive abilities in older adults but the effects of cognitive training on everyday function have not been demonstrated... - Prevalence estimates of depression in elderly community-dwelling African Americans in Indianapolis and Yoruba in Ibadan, NigeriaOlusegun Baiyewu
Department of Psychiatry, College of Medicine, University of Ibadan, Nigeria
Int Psychogeriatr 19:679-89. 2007..This is a community-based longitudinal epidemiological comparative study of elderly African Americans in Indianapolis and elderly Yoruba in Ibadan, Nigeria... - The ACTIVE cognitive training trial and health-related quality of life: protection that lasts for 5 yearsFredric D Wolinsky
Center for Research in the Implementation of Innovative Strategies in Practice, VA Iowa City Health Care System, Iowa, USA
J Gerontol A Biol Sci Med Sci 61:1324-9. 2006..At 5 years post-training, however, all three interventions were successful in protecting against a lower threshold of age-related extensive declines in HRQoL... - APOE epsilon4 is not associated with Alzheimer's disease in elderly NigeriansOye Gureje
Department of Psychiatry, University of Ibadan, College of Medicine, Ibadan, Nigeria
Ann Neurol 59:182-5. 2006..This lack of association in the Yoruba might reflect genetic variation, environmental factors, as well as genetic/environmental interactions...
Research Grants
- CIND: Risk Factors for Conversion to DementiaFrederick Unverzagt; Fiscal Year: 2007....
- CIND: Risk Factors for Conversion to DementiaFrederick W Unverzagt; Fiscal Year: 2010....