Charles H Turner

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. ncbi request reprint Mechanisms by which exercise improves bone strength
    Charles H Turner
    Orthopaedic Research Laboratories and Biomechanics and Biomaterials Research Center, Indiana University Purdue University at Indianapolis, 541 Clinical Drive, Room 541, Indianapolis, IN 46202, USA
    J Bone Miner Metab 23:16-22. 2005
  2. pmc CD44+/CD24- breast cancer cells exhibit enhanced invasive properties: an early step necessary for metastasis
    Carol Sheridan
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Breast Cancer Res 8:R59. 2006
  3. ncbi request reprint Biomechanics of bone: determinants of skeletal fragility and bone quality
    C H Turner
    Biomechanics and Biomaterials Research Center, Indiana University, Indianapolis 46202, USA
    Osteoporos Int 13:97-104. 2002
  4. ncbi request reprint Dentin matrix protein 1 (DMP1)
    C H Turner
    Biomedical Engineering, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202, USA
    J Musculoskelet Neuronal Interact 7:306-7. 2007
  5. ncbi request reprint A cure for osteoporosis?
    C H Turner
    Orthopaedic Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Musculoskelet Neuronal Interact 4:402-3. 2004
  6. pmc Mechanobiology of the skeleton
    Charles H Turner
    Departments of Orthopaedic Surgery and Biomedical Engineering, IUPUI, Indianapolis, IN 46202, USA
    Sci Signal 2:pt3. 2009
  7. ncbi request reprint Bone strength: current concepts
    Charles H Turner
    Orthopaedic Research Laboratories and Biomechanics and Biomaterials Research Center, Indiana University Purdue University at Indianapolis, 1120 South Drive, FH 115, Indianapolis, IN 46202, USA
    Ann N Y Acad Sci 1068:429-46. 2006
  8. ncbi request reprint Designing exercise regimens to increase bone strength
    Charles H Turner
    Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Exerc Sport Sci Rev 31:45-50. 2003
  9. ncbi request reprint Do bone cells behave like a neuronal network?
    C H Turner
    Department of Orthopaedic Surgery, Indiana University School of Medicine and The Biomechanics and Biomaterials Research Center, Indianapolis 46202, USA
    Calcif Tissue Int 70:435-42. 2002
  10. ncbi request reprint The biomechanics of hip fracture
    Charles H Turner
    Department of Biomedical Engineering, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202, USA
    Lancet 366:98-9. 2005

Research Grants

  1. GENETIC ANALYSIS OF HIP FRAGILITY
    Charles Turner; Fiscal Year: 2009
  2. GENETIC ANALYSIS OF HIP FRAGILITY
    Charles Turner; Fiscal Year: 2007
  3. GENETIC ANALYSIS OF HIP FRAGILITY
    Charles Turner; Fiscal Year: 2004
  4. Genetic Analysis of Bone Structure and Strength
    Charles Turner; Fiscal Year: 2006
  5. GENETIC ANALYSIS OF HIP FRAGILITY
    Charles Turner; Fiscal Year: 2006
  6. Genetic Analysis of Bone Structure and Strength
    Charles Turner; Fiscal Year: 2005
  7. GENETIC ANALYSIS OF HIP FRAGILITY
    Charles Turner; Fiscal Year: 2005
  8. GENETIC ANALYSIS OF VERTEBRAL STRENGTH
    Charles Turner; Fiscal Year: 2003
  9. GENETIC ANALYSIS OF HIP FRAGILITY
    Charles Turner; Fiscal Year: 2003
  10. Genetic Analysis of Bone Structure and Strength
    Charles Turner; Fiscal Year: 2007

Collaborators

Detail Information

Publications121 found, 100 shown here

  1. ncbi request reprint Mechanisms by which exercise improves bone strength
    Charles H Turner
    Orthopaedic Research Laboratories and Biomechanics and Biomaterials Research Center, Indiana University Purdue University at Indianapolis, 541 Clinical Drive, Room 541, Indianapolis, IN 46202, USA
    J Bone Miner Metab 23:16-22. 2005
    ..Experimental protocols that insert "rest" periods to reduce the effects of desensitization can double anabolic responses to mechanical loading. Exercises that reduce desensitization may provide an effective means to build bone strength...
  2. pmc CD44+/CD24- breast cancer cells exhibit enhanced invasive properties: an early step necessary for metastasis
    Carol Sheridan
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Breast Cancer Res 8:R59. 2006
    ..The aim of this study was to investigate whether this subpopulation of cancer cells has the unique ability to invade, home, and proliferate at sites of metastasis...
  3. ncbi request reprint Biomechanics of bone: determinants of skeletal fragility and bone quality
    C H Turner
    Biomechanics and Biomaterials Research Center, Indiana University, Indianapolis 46202, USA
    Osteoporos Int 13:97-104. 2002
    ..These findings suggest that there is no single optimal bone architecture; instead many different architectural solutions produce adequate bone strength...
  4. ncbi request reprint Dentin matrix protein 1 (DMP1)
    C H Turner
    Biomedical Engineering, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202, USA
    J Musculoskelet Neuronal Interact 7:306-7. 2007
  5. ncbi request reprint A cure for osteoporosis?
    C H Turner
    Orthopaedic Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Musculoskelet Neuronal Interact 4:402-3. 2004
  6. pmc Mechanobiology of the skeleton
    Charles H Turner
    Departments of Orthopaedic Surgery and Biomedical Engineering, IUPUI, Indianapolis, IN 46202, USA
    Sci Signal 2:pt3. 2009
    ..In particular, focal adhesion kinase and proline-rich tyrosine kinase 2 appear to be sensors of mechanical loads in bone cells...
  7. ncbi request reprint Bone strength: current concepts
    Charles H Turner
    Orthopaedic Research Laboratories and Biomechanics and Biomaterials Research Center, Indiana University Purdue University at Indianapolis, 1120 South Drive, FH 115, Indianapolis, IN 46202, USA
    Ann N Y Acad Sci 1068:429-46. 2006
    ..Several pathways are emerging from current research, including membrane ion channels, ATP signaling, second messengers, such as prostaglandins and nitric oxide, insulin-like growth factors, and Wnt signaling...
  8. ncbi request reprint Designing exercise regimens to increase bone strength
    Charles H Turner
    Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Exerc Sport Sci Rev 31:45-50. 2003
    ..A collection of studies from the clinic and laboratory have provided new insights into how bone building effects of exercise can be maximized. From the available data we have calculated an "osteogenic index" for exercises...
  9. ncbi request reprint Do bone cells behave like a neuronal network?
    C H Turner
    Department of Orthopaedic Surgery, Indiana University School of Medicine and The Biomechanics and Biomaterials Research Center, Indianapolis 46202, USA
    Calcif Tissue Int 70:435-42. 2002
    ..mechanical loading, disuse, and PTH, compared with long bones. We speculate that the history of weight bearing imparts long-term cellular memory to the bone cell network that modulates the cellular response to a wide variety of stimuli...
  10. ncbi request reprint The biomechanics of hip fracture
    Charles H Turner
    Department of Biomedical Engineering, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202, USA
    Lancet 366:98-9. 2005
  11. ncbi request reprint Congenic mice reveal sex-specific genetic regulation of femoral structure and strength
    C H Turner
    Indiana University School of Medicine, Biomechanics and Biomaterials Research Center, 541 Clinical Drive, Room 600, Indianapolis, IN 46202, USA
    Calcif Tissue Int 73:297-303. 2003
    ....
  12. pmc Exercises for improving bone strength
    C H Turner
    Department of Biomedical Engineering, 1120 South Drive, FH 115, Indianapolis, IN 46202, USA
    Br J Sports Med 39:188-9. 2005
  13. ncbi request reprint Exercise as an anabolic stimulus for bone
    Charles H Turner
    Orthopaedic Research Laboratories and Biomechanics and Biomaterials Research Center, Indiana University Purdue University at Indianapolis, Indianapolis, IN 46202, USA
    Curr Pharm Des 10:2629-41. 2004
    ..A drug therapy that suppresses desensitization pathways may provide an effective means to build bone strength...
  14. ncbi request reprint Aging and fragility of bone
    C H Turner
    Biomedical Engineering, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202, USA
    J Musculoskelet Neuronal Interact 7:342-3. 2007
  15. pmc Differentially expressed genes strongly correlated with femur strength in rats
    Imranul Alam
    Department of Biomedical Engineering, Indiana University Purdue University Indianapolis IUPUI, Indianapolis, IN 46202 5251, USA
    Genomics 94:257-62. 2009
    ....
  16. pmc Genetic loci affecting bone structure and strength in inbred COP and DA rats
    Qiwei Sun
    Department of Biomedical Engineering, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Bone 42:547-53. 2008
    ..Our study demonstrates strong evidence of linkage for bone structure and strength to multiple rat chromosomes...
  17. ncbi request reprint Genetic effects on bone mechanotransduction in congenic mice harboring bone size and strength quantitative trait loci
    Alexander G Robling
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Bone Miner Res 22:984-91. 2007
    ..Bone size was not consistently associated with mechano-responsiveness, indicating that the genetic regulation of mechanotransduction is a complex process that involves a number of genes and is sex-specific...
  18. pmc Genes influencing spinal bone mineral density in inbred F344, LEW, COP, and DA rats
    Imranul Alam
    Department of Biomedical Engineering, Indiana University Purdue University Indianapolis, 46202 5251, USA
    Funct Integr Genomics 10:63-72. 2010
    ..Of these, 14 genes (Akap1, Asgr2, Esd, Fam101b, Irf1, Lcp1, Ltc4s, Mdp-1, Pdhb, Plxdc1, Rabep1, Rhot1, Slc2a4, Xpo4) were confirmed by qPCR. We identified several novel candidate genes influencing spinal vBMD in rats...
  19. pmc Linkage screen for BMD phenotypes in male and female COP and DA rat strains
    Daniel L Koller
    Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana 46202, USA
    J Bone Miner Res 23:1382-8. 2008
    ..These results confirm that the genetic influence on BMD in the rat model is quite complex and would seem to be influenced by a number of different genes, some of which have sex-specific effects...
  20. ncbi request reprint The Wnt co-receptor LRP5 is essential for skeletal mechanotransduction but not for the anabolic bone response to parathyroid hormone treatment
    Kimihiko Sawakami
    Department of Orthopedic Surgery, Biomechanics and Biomaterials Research Center, Indiana University School of Medicine, Indianapolis 46202, USA
    J Biol Chem 281:23698-711. 2006
    ....
  21. ncbi request reprint Genome screen for bone mineral density phenotypes in Fisher 344 and Lewis rat strains
    Daniel L Koller
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, 975 West Walnut Street, IB 130, Indianapolis, Indiana, 46202, USA
    Mamm Genome 16:578-86. 2005
    ..0. The region on rat Chromosome 8 is syntenic to human Chromosome 15, where linkage to spine and femur BMD has been previously reported and confirmed in a sample of premenopausal women...
  22. pmc Genomic expression analysis of rat chromosome 4 for skeletal traits at femoral neck
    Imranul Alam
    Department of Biomedical Engineering, Indiana University Purdue University Indianapolis, Indianapolis, Indiana 46202, USA
    Physiol Genomics 35:191-6. 2008
    ..This study provides a shortened list of genetic determinants of skeletal traits at the hip and may lead to novel approaches for prevention and treatment of hip fracture...
  23. pmc Sex-specific genetic loci for femoral neck bone mass and strength identified in inbred COP and DA rats
    Imranul Alam
    Department of Biomedical Engineering, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Bone Miner Res 23:850-9. 2008
    ..The purpose of this study is to identify sex-independent and sex-specific quantitative trait loci (QTLs) for femoral neck density, structure, and strength in inbred Copenhagen 2331 (COP) and Dark Agouti (DA) rats...
  24. ncbi request reprint Whole-genome scan for linkage to bone strength and structure in inbred Fischer 344 and Lewis rats
    Imranul Alam
    Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Bone Miner Res 20:1589-96. 2005
    ..A genome-wide genetic linkage analysis identified several chromosomal regions influencing bone strength and structure in F2 progeny of Fischer 344 x Lewis inbred rats...
  25. pmc Identification of genes influencing skeletal phenotypes in congenic P/NP rats
    Imranul Alam
    Department of Biomedical Engineering, Indiana University Purdue University Indianapolis IUPUI, Indianapolis, IN 46202, USA
    J Bone Miner Res 25:1314-25. 2010
    ..We identified several candidate genes, including some novel genes on chromosome 4 segregating for skeletal phenotypes in reciprocal congenic P and NP rats...
  26. pmc Epistatic effects contribute to variation in BMD in Fischer 344 x Lewis F2 rats
    Daniel L Koller
    Department of Medical and Molecular Genetics, Indiana University, Purdue University Indianapolis, Indianapolis, Indiana, USA
    J Bone Miner Res 23:41-7. 2008
    ..Several significant interactions were identified, involving both previously identified and novel QTLs...
  27. pmc Heterogeneous stock rat: a unique animal model for mapping genes influencing bone fragility
    Imranul Alam
    Indiana University School of Medicine, Indiana University Indianapolis, IN, USA
    Bone 48:1169-77. 2011
    ....
  28. ncbi request reprint Low-amplitude, broad-frequency vibration effects on cortical bone formation in mice
    Alesha B Castillo
    Department of Biomedical Engineering, Purdue School of Engineering and Technology, Indiana University School of Medicine, 1120 South Drive, Indianapolis, IN 46202, USA
    Bone 39:1087-96. 2006
    ..Our data suggest that low-amplitude, broad-frequency vibration superimposed onto an osteogenic waveform or vibration alone does not enhance cortical bone adaptation at the frequencies, amplitudes and loading periods tested...
  29. ncbi request reprint Lengthening of mouse hindlimbs with joint loading
    Ping Zhang
    Department of Biomedical Engineering, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202, USA
    J Bone Miner Metab 28:268-75. 2010
    ..01) as well as their cellular height (P < 0.001) along the length of the tibia. Taken together, this study demonstrates for the first time the potential effectiveness of knee loading in adjusting limb length discrepancy...
  30. ncbi request reprint Bone adaptation to a mechanical loading program significantly increases skeletal fatigue resistance
    Stuart J Warden
    Department of Physical Therapy, School of Health and Rehabilitation Sciences, Indiana University, Indianapolis, Indiana 46202, USA
    J Bone Miner Res 20:809-16. 2005
    ..This indicates that a moderate exercise program may be an effective preventative strategy for stress fractures...
  31. ncbi request reprint Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin
    Alexander G Robling
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 283:5866-75. 2008
    ....
  32. pmc Frequency-dependent enhancement of bone formation in murine tibiae and femora with knee loading
    Ping Zhang
    Department of Biomedical Engineering, Indiana University Purdue University Indianapolis IUPUI, Fesler Hall 115, 1120 South Drive, Indianapolis, IN 46202, USA
    J Bone Miner Metab 25:383-91. 2007
    ..2-, and 1.8 fold, respectively). We observed that the tibia had a lower bone mineral density with more porous microstructures than the femur. Those differences may contribute to the observed differential dependence on loading frequencies...
  33. doi request reprint P2X7 nucleotide receptor plays an important role in callus remodeling during fracture repair
    Jiliang Li
    Department of Biology, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202, USA
    Calcif Tissue Int 84:405-12. 2009
    ..However, callus remodeling was significantly delayed. Our data suggest the different role of the P2X7R in woven bone and lamellar bone formation...
  34. ncbi request reprint Interrelationships between bone microarchitecture and strength in ovariectomized monkeys treated with teriparatide
    Peiqi Chen
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Bone Miner Res 22:841-8. 2007
    ..However, the data taken together showed the importance of cortical bone volume for vertebra to assess pharmacological effects on bone quality...
  35. pmc Segmental bone regeneration using a load-bearing biodegradable carrier of bone morphogenetic protein-2
    Tien Min G Chu
    Department of Biomedical Engineering, Purdue School of Engineering and Technology, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202, USA
    Biomaterials 28:459-67. 2007
    ..Our results demonstrated that the load-bearing BMP-2 scaffold can maintain bone length and allow successfully regeneration in segmental defects...
  36. ncbi request reprint Parathyroid hormone enhances mechanically induced bone formation, possibly involving L-type voltage-sensitive calcium channels
    Jiliang Li
    Department of Orthopedic Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Endocrinology 144:1226-33. 2003
    ..This study indicates that L-type VSCCs mediate load-induced bone formation in vivo. Furthermore, PTH enhances load-induced bone adaptation through involvement of L-type VSCCs...
  37. ncbi request reprint The P2X7 nucleotide receptor mediates skeletal mechanotransduction
    Jiliang Li
    Department of Anatomy and Cell Biology and Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 280:42952-9. 2005
    ..We conclude that ATP signaling through P2X7R is necessary for mechanically induced release of prostaglandins by bone cells and subsequent osteogenesis...
  38. ncbi request reprint Bone mass and strength: phenotypic and genetic relationship to alcohol preference in P/NP and HAD/LAD rats
    Imranul Alam
    Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Alcohol Clin Exp Res 29:1769-76. 2005
    ..In this study, we determined whether there is a relationship between alcohol preference and high bone mass or strength and whether bone mass-regulating genes segregate during selective breeding of alcohol preferring rats...
  39. pmc Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading
    Xiaolin Tu
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Bone 50:209-17. 2012
    ..Thus, downregulation of Sost/sclerostin in osteocytes is an obligatory step in the mechanotransduction cascade that activates Wnt signaling and directs osteogenesis to where bone is structurally needed...
  40. ncbi request reprint Genetic effects for femoral biomechanics, structure, and density in C57BL/6J and C3H/HeJ inbred mouse strains
    Daniel L Koller
    Department of Medical and Molecular Genetics, Indiana University, Purdue University Indianapolis, Indianapolis, Indiana, USA
    J Bone Miner Res 18:1758-65. 2003
    ..Highly significant QTLs were detected with pleiotropic effects on many of these phenotypes, and QTLs with unique effects on specific phenotypes were found as well...
  41. ncbi request reprint Cellular accommodation and the response of bone to mechanical loading
    Jennifer L Schriefer
    Department of Biomedical Engineering, Purdue School of Engineering and Technology, Indiana University Purdue University Indianapolis, IN 46202, USA
    J Biomech 38:1838-45. 2005
    ..After the initial weeks of loading, bone stopped responding so the degree of adaptation was proportional to the initial peak load magnitude...
  42. ncbi request reprint Evidence for a skeletal mechanosensitivity gene on mouse chromosome 4
    Alexander G Robling
    Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    FASEB J 17:324-6. 2003
    ..Collectively, the results might explain why 4T mice have wider femora and ulnae than do B6 control mice and suggest that mouse Chr. 4 contains a genetic locus that modulates the mechanosensitivity of bone tissue...
  43. pmc Mechanical signaling for bone modeling and remodeling
    Alexander G Robling
    Department of Anatomy, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Crit Rev Eukaryot Gene Expr 19:319-38. 2009
    ..Collectively, these data highlight the complex yet finely orchestrated process of mechanically regulated bone homeostasis...
  44. pmc Epistasis between QTLs for bone density variation in Copenhagen x dark agouti F2 rats
    Daniel L Koller
    Department of Medical and Molecular Genetics, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202, USA
    Mamm Genome 20:180-6. 2009
    ..These results provide new information regarding the mode of action of previously identified QTL in the rat, as well as identifying novel loci that act in combination with known QTL or with other novel loci to contribute to BMD variation...
  45. ncbi request reprint Biomechanical and molecular regulation of bone remodeling
    Alexander G Robling
    Department of Anatomy and Cell Biology, Indiana University Purdue University, Indianapolis, Indiana 46202, USA
    Annu Rev Biomed Eng 8:455-98. 2006
    ..Many of these processes have implications for bone health, disease, and the feasibility of living in weightless environments (e.g., spaceflight)...
  46. ncbi request reprint Effects of broad frequency vibration on cultured osteoblasts
    Shigeo M Tanaka
    Department of Orthopedic Surgery, Biomaterials and Biomechanics Research Center, Indiana University School of Medicine, 541 Clinical Drive, Room 600, Indianapolis, IN 46202 5111, USA
    J Biomech 36:73-80. 2003
    ..This suggestion implies a potential contribution of stochastic resonance to the mechanical sensitivity of osteoblasts...
  47. pmc Activation of extracellular-signal regulated kinase (ERK1/2) by fluid shear is Ca(2+)- and ATP-dependent in MC3T3-E1 osteoblasts
    Dawei Liu
    Department of Developmental Sciences and Orthodontics, Marquette University School of Dentistry, Milwaukee, WI, USA Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
    Bone 42:644-52. 2008
    ..Further, this ATP-dependent ERK1/2 phosphorylation is mediated through P2X7, but not P2Y2, purinergic receptors...
  48. ncbi request reprint Knee ligament mechanical properties are not influenced by estrogen or its receptors
    Stuart J Warden
    Dept of Physical Therapy, School of Health and Rehabilitation Sciences, Indiana University, 1140 W Michigan St, CF 326, Indianapolis, IN 46202, USA
    Am J Physiol Endocrinol Metab 290:E1034-40. 2006
    ....
  49. pmc Anabolic and catabolic regimens of human parathyroid hormone 1-34 elicit bone- and envelope-specific attenuation of skeletal effects in Sost-deficient mice
    Alexander G Robling
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, MS 5035, Indianapolis, Indiana 46202, USA
    Endocrinology 152:2963-75. 2011
    ..Furthermore, Sost deletion protects some trabecular compartments, but not cortical compartments, from bone loss induced by high-dose PTH infusion...
  50. doi request reprint Serotonin (5-hydroxytryptamine) transporter inhibition causes bone loss in adult mice independently of estrogen deficiency
    Stuart J Warden
    Department of Physical Therapy, School of Health and Rehabilitation Sciences, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Menopause 15:1176-83. 2008
    ..This study aimed to explore the influence of an SSRI (fluoxetine hydrochloride) on the bone changes associated with estrogen deficiency in adult mice...
  51. pmc Psychotropic drugs have contrasting skeletal effects that are independent of their effects on physical activity levels
    Stuart J Warden
    Department of Physical Therapy, School of Health and Rehabilitation Sciences, Indiana University, Indianapolis, IN 46202, USA
    Bone 46:985-92. 2010
    ....
  52. ncbi request reprint Dissociation of mineral and collagen orientations may differentially adapt compact bone for regional loading environments: results from acoustic velocity measurements in deer calcanei
    John G Skedros
    Department of Orthopaedic Surgery, University of Utah, and Bone and Joint Research Laboratory, Department of Veteran s Affairs Medical Center, Salt Lake City, UT 84107, USA
    Bone 39:143-51. 2006
    ....
  53. ncbi request reprint Teriparatide [PTH(1-34)] strengthens the proximal femur of ovariectomized nonhuman primates despite increasing porosity
    Masahiko Sato
    Lilly Research Laboratories, Indianapolis, Indiana 46285, USA
    J Bone Miner Res 19:623-9. 2004
    ..Beneficial effects of teriparatide treatment on the proximal femur persisted beyond the treatment period and may extend to the marrow...
  54. ncbi request reprint A comparison of mechanical properties derived from multiple skeletal sites in mice
    Jennifer L Schriefer
    Department of Biomedical Engineering, Purdue School of Engineering and Technology, Purdue University, Indianapolis, IN, USA
    J Biomech 38:467-75. 2005
    ..Of the bones tested, the radius was preferred for mechanical testing because of its high aspect ratio, minimal measurement error, and low variability...
  55. ncbi request reprint Low-dose estrogen treatment suppresses periosteal bone formation in response to mechanical loading
    Leanne K Saxon
    Department of Orthopaedic Surgery and Biomedical Engineering, IUPUI, Indianapolis, IN 46202, USA
    Bone 39:1261-7. 2006
    ..We conclude low-dose EE2 suppresses the mechanical loading response on the periosteal surface of long bones, but had no effect on the loading response at the endocortical bone surface in growing male rats...
  56. ncbi request reprint Inhibition of the serotonin (5-hydroxytryptamine) transporter reduces bone accrual during growth
    Stuart J Warden
    Department of Orthopaedic Surgery, Indiana University, 1140 West Michigan Street, CF 326, Indianapolis, Indiana 46202, USA
    Endocrinology 146:685-93. 2005
    ..These findings indicate a role for the 5-HTT in the regulation of bone accrual in the growing skeleton and point to a need for further research into the prescription of SSRIs to children and adolescents...
  57. pmc The emerging role of serotonin (5-hydroxytryptamine) in the skeleton and its mediation of the skeletal effects of low-density lipoprotein receptor-related protein 5 (LRP5)
    Stuart J Warden
    Department of Physical Therapy, School of Health and Rehabilitation Sciences, Indiana University, Indianapolis, IN 46202, USA
    Bone 46:4-12. 2010
    ..This paper discusses the mounting evidence for skeletal effects of 5-HT and the ability of gut-derived 5-HT to satisfactorily explain the skeletal effects of LRP5...
  58. ncbi request reprint Effects of human parathyroid hormone (1-34), LY333334, on bone mass, remodeling, and mechanical properties of cortical bone during the first remodeling cycle in rabbits
    T Mashiba
    Department of Anatomy and Cell Biology, Research Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Bone 28:538-47. 2001
    ..There is no mechanical risk during the first remodeling cycle associated with intermittent PTH treatment in animals with normal bone mass...
  59. ncbi request reprint The skeletal responsiveness to mechanical loading is enhanced in mice with a null mutation in estrogen receptor-beta
    L K Saxon
    Department of Orthopaedic Surgery, Indiana University Purdue University, Indianapolis, USA
    Am J Physiol Endocrinol Metab 293:E484-91. 2007
    ..001). We conclude that estrogen signaling through ER-beta suppresses the mechanical loading response on the periosteal surface of long bones...
  60. ncbi request reprint Biosynthetic human parathyroid hormone (1-34) effects on bone quality in aged ovariectomized rats
    M Sato
    Department of Endocrine Research, Lilly Research Laboratories, Indianapolis, Indiana 46285, USA
    Endocrinology 138:4330-7. 1997
    ..PTH slightly increased body weight above OVX. In addition, PTH did not interfere with the beneficial effects of ovariectomy on rat longevity...
  61. ncbi request reprint Mechanotransduction in bone does not require a functional cyclooxygenase-2 (COX-2) gene
    Imranul Alam
    Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Bone Miner Res 20:438-46. 2005
    ..However, using mice with a null mutation of the COX-2 gene, we found that a functional COX-2 gene is not required for mechanotransduction. This paradoxical finding may have resulted, in part, from mechanically induced COX-1 activity...
  62. ncbi request reprint Shorter, more frequent mechanical loading sessions enhance bone mass
    Alexander G Robling
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Med Sci Sports Exerc 34:196-202. 2002
    ..We investigated whether the osteogenic response to a simulated high-impact exercise program lasting 4 months could be enhanced by dividing the daily protocol into brief sessions of loading, separated by recovery periods...
  63. pmc Joint loading-driven bone formation and signaling pathways predicted from genome-wide expression profiles
    Ping Zhang
    Department of Biomedical Engineering, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202, USA
    Bone 44:989-98. 2009
    ..Since ankle loading stimulates bone formation throughout the tibia both in the endosteum and the periosteum, it may provide a non-pharmacological approach to effectively activate molecular signaling necessary for preventing bone loss...
  64. ncbi request reprint Exercise when young provides lifelong benefits to bone structure and strength
    Stuart J Warden
    Department of Physical Therapy, Indiana University, Indianapolis, USA
    J Bone Miner Res 22:251-9. 2007
    ..Consequently, exercise when young may reduce the risk for fractures later in life, and the old exercise adage of "use it or lose it" may not be entirely applicable to the skeleton...
  65. ncbi request reprint Skeletal efficacy with parathyroid hormone in rats was not entirely beneficial with long-term treatment
    Masahiko Sato
    Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285, USA
    J Pharmacol Exp Ther 302:304-13. 2002
    ..However, compared with short-term studies reported previously, there seemed to be no advantages to extending PTH treatment to 12 months in rat bones...
  66. ncbi request reprint A model for mechanotransduction in bone cells: the load-bearing mechanosomes
    Fred M Pavalko
    Department of Cellular and Integrative Physiology, Indiana University School of Medicine IUSM, Indianapolis, Indiana 46202, USA
    J Cell Biochem 88:104-12. 2003
    ..We identify specific candidate proteins fitting the profile of load-signaling mechanosomes...
  67. pmc Gene expression patterns in bone following mechanical loading
    Sara M Mantila Roosa
    Department of Biomedical Engineering, Purdue University, West Lafayette, IN, USA
    J Bone Miner Res 26:100-12. 2011
    ....
  68. ncbi request reprint Stochastic resonance in osteogenic response to mechanical loading
    Shigeo M Tanaka
    Department of Orhopaedic Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA
    FASEB J 17:313-4. 2003
    ..It was concluded that adding low magnitude vibration greatly enhanced bone formation in response to loading, suggesting a contribution of stochastic resonance in the osteogenic response...
  69. pmc Alternative splicing in bone following mechanical loading
    Sara M Mantila Roosa
    Department of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA
    Bone 48:543-51. 2011
    ..In conclusion, mechanical loading induces alternative splicing in bone, which may play an important role in the response of bone to mechanical loading...
  70. ncbi request reprint Effects of high-dose etidronate treatment on microdamage accumulation and biomechanical properties in beagle bone before occurrence of spontaneous fractures
    T Mashiba
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Bone 29:271-8. 2001
    ..These findings suggest that suppression of bone remodeling by EHDP allows microdamage accumulation, but that osteoid accumulation reduces production of microdamage...
  71. ncbi request reprint Identification of a quantitative trait locus on rat chromosome 4 that is strongly linked to femoral neck structure and strength
    I Alam
    Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Bone 39:93-9. 2006
    ..These findings represent an important first step in localizing and identifying genes that influence hip fragility...
  72. ncbi request reprint Effects of suppressed bone turnover by bisphosphonates on microdamage accumulation and biomechanical properties in clinically relevant skeletal sites in beagles
    T Mashiba
    Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Bone 28:524-31. 2001
    ....
  73. ncbi request reprint Decreased bone mass and bone elasticity in mice lacking the transforming growth factor-beta1 gene
    A G Geiser
    Endocrine Division of Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Bone 23:87-93. 1998
    ..These data show that longitudinal growth and total mineral content are affected in mice lacking TGF-beta1, as well as the elastic properties of the bone, consistent with an important role for TGF-beta1 in bone modeling and bone quality...
  74. ncbi request reprint Novel injectable and in situ curable glycolide/lactide based biodegradable polymer resins and composites
    Dong Xie
    Department of Biomedical Engineering, Purdue School of Engineering and Technology, Indiana University Purdue University at Indianapolis Indianapolis, IN 46202, USA
    J Biomater Appl 22:33-54. 2007
    ..The composites completely lose their strengths at different time intervals, depending on their molar ratio and filler content. The degradation rate is found to be molar ratio and filler-content dependent...
  75. ncbi request reprint Neural regulation of bone and the skeletal effects of serotonin (5-hydroxytryptamine)
    Stuart J Warden
    Department of Physical Therapy, Indiana University, 1140 W Michigan Street, CF 326, Indianapolis, IN 46202, USA
    Mol Cell Endocrinol 242:1-9. 2005
    ..Initial data suggest that exposure to these agents at different stages during the lifespan may have significant effects on the skeleton...
  76. ncbi request reprint Genetics of osteoporosis
    Munro Peacock
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Endocr Rev 23:303-26. 2002
    ..As with all genetic studies in humans, these scientific advances will need to be made in an environment of legal and ethical safeguards that are acceptable to the general public...
  77. ncbi request reprint Mechanotransduction in bone: genetic effects on mechanosensitivity in mice
    A G Robling
    Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis 46202, USA
    Bone 31:562-9. 2002
    ..Identification of the genes that exert their influence on mechanosensitivity could ultimately lead to therapies that enhance bone mass and reduce fracture susceptibility...
  78. ncbi request reprint Mechanical stimulation in vivo reduces osteocyte expression of sclerostin
    A G Robling
    Indiana University School of Medicine, Department of Anatomy and Cell Biology, Indianapolis, IN 46032, USA
    J Musculoskelet Neuronal Interact 6:354. 2006
  79. ncbi request reprint Mechanotransduction in the cortical bone is most efficient at loading frequencies of 5-10 Hz
    S J Warden
    Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Bone 34:261-70. 2004
    ..The obtained findings may relate to the mechanism of mechanotransduction within the bone. This requires further investigation...
  80. ncbi request reprint Reductions in bone strength after fluoride treatment are not reflected in tissue-level acoustic measurements
    C H Turner
    Biomechanics and Biomaterials Research Center, Indiana University Medical Center, Indianapolis 46202, USA
    Bone 19:603-7. 1996
    ..These data cast doubt on the utility of high frequency (>2 MHz) acoustic measurements for evaluating the efficacy of fluoride therapy, especially in the hip...
  81. ncbi request reprint Estrogen receptor beta: the antimechanostat?
    L K Saxon
    Department of Orthopaedic Surgery, Indiana University, Indianapolis, IN 46202 5113, USA
    Bone 36:185-92. 2005
    ..Signaling through this receptor retards periosteal bone formation and suppresses gains in bone size and bone strength, and for these reasons it behaves as an antimechanostat...
  82. ncbi request reprint Skeletal phenotype of mice with a null mutation in Cav 1.3 L-type calcium channel
    J Li
    Department of Biology, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202, USA
    J Musculoskelet Neuronal Interact 10:180-7. 2010
    ..Cav1.3 does not mediate osteoblast response to mechanical loading and PTH. Our data suggest that Cav1.1 and Cav1.2 subunits may substitute for Cav1.3 to maintain bone response to mechanical loading...
  83. ncbi request reprint Recovery periods restore mechanosensitivity to dynamically loaded bone
    A G Robling
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA
    J Exp Biol 204:3389-99. 2001
    ..The results demonstrate the importance of recovery periods for (i) restoring mechanosensitivity to bone cells and (ii) maximizing the osteogenic effects of mechanical loading (exercise) regimens...
  84. ncbi request reprint The elastic properties of trabecular and cortical bone tissues are similar: results from two microscopic measurement techniques
    C H Turner
    Biomechanics and Biomaterials Research Center, Indiana University Medical Center, Indianapolis 46202, USA
    J Biomech 32:437-41. 1999
    ....
  85. ncbi request reprint Does exercise during growth influence osteoporotic fracture risk later in life?
    S J Warden
    Department of Physical Therapy, Indiana University, Indianapolis, IN 46202, USA
    J Musculoskelet Neuronal Interact 5:344-6. 2005
  86. ncbi request reprint High fluoride intakes cause osteomalacia and diminished bone strength in rats with renal deficiency
    C H Turner
    Biomechanics and Biomaterials Research Center, Indiana University Schools of Medicine and Dentistry, Indianapolis 46202, USA
    Bone 19:595-601. 1996
    ..In conclusion, fluoridated water in concentrations equivalent to 3 and 10 ppm in humans, caused osteomalacia and reduced bone strength in rats with surgically-induced renal deficiency...
  87. ncbi request reprint Does microdamage accumulation affect the mechanical properties of bone?
    D B Burr
    Department of Anatomy, Indiana University School of Medicine, Indianapolis 46202, USA
    J Biomech 31:337-45. 1998
    ..We also conclude that damage accumulates more rapidly in tensile cortices, but crack growth is greater in compressive cortices...
  88. ncbi request reprint Preliminary evaluation of a load-bearing BMP-2 carrier for segmental defect regeneration
    Tien Min G Chu
    Department of Biomedical Engineering, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202, USA
    Biomed Sci Instrum 42:42-7. 2006
    ..Histology analysis shows that a normal fatty bone marrow was restored and mineralized callus formed and bridged the segmental defect...
  89. pmc Knee loading accelerates bone healing in mice
    Ping Zhang
    Department of Biomedical Engineering, Indiana University Purdue University, Indianapolis, IN 46202, USA
    J Bone Miner Res 22:1979-87. 2007
    ..Knee loading is an anabolic loading modality that applies lateral loads to the knee. This study shows that loads applied to the proximal tibial epiphysis stimulate healing of surgically generated wounds in the tibial diaphysis...
  90. ncbi request reprint Mechanical loading of diaphyseal bone in vivo: the strain threshold for an osteogenic response varies with location
    Y F Hsieh
    Department of Orthopedic Surgery, Indiana University School of Medicine, Indianapolis 46202, USA
    J Bone Miner Res 16:2291-7. 2001
    ..The threshold strain is largest distally, where locomotor bone strains are typically higher and smallest proximally where locomotor bone strains are lower...
  91. ncbi request reprint Combined effects of diets with reduced calcium and phosphate and increased fluoride intake on vertebral bone strength and histology in rats
    C H Turner
    Biomechanics and Biomaterials Research Center, Indiana University School of Medicine, Indianapolis 46202, USA
    Calcif Tissue Int 69:51-7. 2001
    ..This impairment of mineralization by fluoride appeared to be the primary cause of the diminished vertebral strength. The detrimental effects of fluoride on vertebral bone strength were not amplified by calcium phosphate deficiency...
  92. ncbi request reprint LY353381 x HCl: an improved benzothiophene analog with bone efficacy complementary to parathyroid hormone-(1-34)
    M Sato
    Lilly Research Laboratories, Eli Lilly and Co, Lilly Corporate Center, Indianapolis, Indiana 46285, USA
    Endocrinology 139:4642-51. 1998
    ..Therefore, LY353381 x HCl appears to be useful by itself, in combination, or in sequence with PTH to replace lost bone in postmenopausal women...
  93. ncbi request reprint Mechanosensitivity of the rat skeleton decreases after a long period of loading, but is improved with time off
    L K Saxon
    Department of Orthopaedic Surgery, IUPUI, Room 600, 541 Clinical Drive, Indianapolis, IN 46202, USA
    Bone 36:454-64. 2005
    ..Having time off increases bone formation and improves the resistance to fracture...
  94. ncbi request reprint Variation in bone biomechanical properties, microstructure, and density in BXH recombinant inbred mice
    C H Turner
    Biomechanics and Biomaterials Research Center, Indiana University, Indianapolis 46202, USA
    J Bone Miner Res 16:206-13. 2001
    ..Finally, vertebral strength was not correlated consistently with femoral strength among the BXH RI strains, suggesting genetic regulation of bone strength is site specific...
  95. ncbi request reprint Two inbred rat strains that differ substantially in hip fragility
    Q Sun
    Department of Orthopaedic Surgery, The Biomechanics and Biomaterials Research Center, Indiana University School of Medicine, Indianapolis 46202, USA
    Calcif Tissue Int 72:498-504. 2003
    ..Therefore these two inbred strains, COP with DA, may facilitate effective genetic studies of hip fragility...
  96. ncbi request reprint Improved bone structure and strength after long-term mechanical loading is greatest if loading is separated into short bouts
    Alexander G Robling
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis 46202, USA
    J Bone Miner Res 17:1545-54. 2002
    ..Modest increases in aBMD and BMC can improve biomechanical properties substantially if the new bone formation is localized to the most biomechanically relevant sites, as occurs during load-induced bone formation...
  97. ncbi request reprint Long-term dosing of arzoxifene lowers cholesterol, reduces bone turnover, and preserves bone quality in ovariectomized rats
    Yanfei L Ma
    Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana 46285, USA
    J Bone Miner Res 17:2256-64. 2002
    ..These data suggest that arzoxifene may be a useful therapeutic agent for osteoporosis in postmenopausal women...
  98. ncbi request reprint L-type calcium channels mediate mechanically induced bone formation in vivo
    Jiliang Li
    Department of Orthopedic Surgery, Indiana University School of Medicine, Indianapolis 46202, USA
    J Bone Miner Res 17:1795-800. 2002
    ....
  99. ncbi request reprint Bone remodeling at the iliac crest can predict the changes in remodeling dynamics, microdamage accumulation, and mechanical properties in the lumbar vertebrae of dogs
    T Mashiba
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Calcif Tissue Int 77:180-5. 2005
    ..f in the ilium. These results clearly indicate that bone remodeling data obtained from iliac crest biopsy could be used to estimate the activation frequency and microdamage burden in the vertebral column...
  100. ncbi request reprint Three-dimensional modeling of the effects of parathyroid hormone on bone distribution in lumbar vertebrae of ovariectomized cynomolgus macaques
    M Sato
    Endocrine Division, Lilly Research Laboratories, Indianapolis, IN 46285, USA
    Osteoporos Int 11:871-80. 2000
    ..These data show that even transient PTH treatment improves vertebral architecture and bone quality to reduce the likelihood of fracture, and that transient treatment is better than no PTH treatment at all...
  101. ncbi request reprint Modulation of appositional and longitudinal bone growth in the rat ulna by applied static and dynamic force
    A G Robling
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, USA
    Bone 29:105-13. 2001
    ....

Research Grants13

  1. GENETIC ANALYSIS OF HIP FRAGILITY
    Charles Turner; Fiscal Year: 2009
    ..Our goal is to find genetic causes for bone weakening conditions like osteoporosis so better treatments can be developed. ..
  2. GENETIC ANALYSIS OF HIP FRAGILITY
    Charles Turner; Fiscal Year: 2007
    ..We anticipate that these analyses will identify some QTLs previously linked to femoral neck fragility in Aim 2, as well as novel QTLs specifically influencing femoral shaft phenotypes. ..
  3. GENETIC ANALYSIS OF HIP FRAGILITY
    Charles Turner; Fiscal Year: 2004
    ..We anticipate that these analyses will identify some QTLs previously linked to femoral neck fragility in Aim 2, as well as novel QTLs specifically influencing femoral shaft phenotypes. ..
  4. Genetic Analysis of Bone Structure and Strength
    Charles Turner; Fiscal Year: 2006
    ..abstract_text> ..
  5. GENETIC ANALYSIS OF HIP FRAGILITY
    Charles Turner; Fiscal Year: 2006
    ..We anticipate that these analyses will identify some QTLs previously linked to femoral neck fragility in Aim 2, as well as novel QTLs specifically influencing femoral shaft phenotypes. ..
  6. Genetic Analysis of Bone Structure and Strength
    Charles Turner; Fiscal Year: 2005
    ..abstract_text> ..
  7. GENETIC ANALYSIS OF HIP FRAGILITY
    Charles Turner; Fiscal Year: 2005
    ..We anticipate that these analyses will identify some QTLs previously linked to femoral neck fragility in Aim 2, as well as novel QTLs specifically influencing femoral shaft phenotypes. ..
  8. GENETIC ANALYSIS OF VERTEBRAL STRENGTH
    Charles Turner; Fiscal Year: 2003
    ..Finally, the genetic effects on femoral and vertebral microstructure during growth and development will be analyzed for different inbred strains of mice using muCT and biomechanical testing. ..
  9. GENETIC ANALYSIS OF HIP FRAGILITY
    Charles Turner; Fiscal Year: 2003
    ..We anticipate that these analyses will identify some QTLs previously linked to femoral neck fragility in Aim 2, as well as novel QTLs specifically influencing femoral shaft phenotypes. ..
  10. Genetic Analysis of Bone Structure and Strength
    Charles Turner; Fiscal Year: 2007
    ..abstract_text> ..
  11. GENETIC ANALYSIS OF VERTEBRAL STRENGTH
    Charles Turner; Fiscal Year: 2002
    ..Finally, the genetic effects on femoral and vertebral microstructure during growth and development will be analyzed for different inbred strains of mice using muCT and biomechanical testing. ..
  12. GENETIC ANALYSIS OF VERTEBRAL STRENGTH
    Charles Turner; Fiscal Year: 2001
    ..Finally, the genetic effects on femoral and vertebral microstructure during growth and development will be analyzed for different inbred strains of mice using muCT and biomechanical testing. ..