G Tunnicliff

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. ncbi request reprint Gamma-Hydroxybutyrate (orphan medical)
    Godfrey Tunnicliff
    Indiana University School of Medicine, Evansville 47712, USA
    Curr Opin Investig Drugs 3:278-83. 2002
  2. ncbi request reprint Central GABAergic systems and depressive illness
    G Tunnicliff
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, 8600 University Boulevard, Evansville, Indiana 47712, USA
    Neurochem Res 28:965-76. 2003
  3. ncbi request reprint Action of 4-amino-2-fluorobutanoic acid and other structural analogues on gamma-aminobutyric acid transport by channel catfish brain
    Glenda J Crites
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Evansville, IN 47712, USA
    J Basic Clin Physiol Pharmacol 13:179-92. 2002
  4. ncbi request reprint Membrane glycine transport proteins
    Godfrey Tunnicliff
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Evansville, Ind 47712, USA
    J Biomed Sci 10:30-6. 2003
  5. ncbi request reprint Pharmacology and function of imidazole 4-acetic acid in brain
    G Tunnicliff
    Laboratory of Neurochemistry, Indiana University School of Medicine, Evansville 47712, USA
    Gen Pharmacol 31:503-9. 1998
  6. ncbi request reprint The GABA(A) receptor complex as a target for fluoxetine action
    G Tunnicliff
    Department of Biochemistry, Indiana University School of Medicine, Evansville 47712, USA
    Neurochem Res 24:1271-6. 1999
  7. ncbi request reprint Effects of treatment with GABA(A) receptor subunit antisense oligodeoxynucleotides on GABA-stimulated 36Cl- influx in the rat cerebral cortex
    E Malatynska
    Department of Pharmacology and Toxicology, Indiana University, School of Medicine, Evansville 47712, USA
    Neurochem Int 36:45-54. 2000
  8. ncbi request reprint Chemical modification of bacterial 4-aminobutyrate aminotransferase by phenylglyoxal
    G Tunnicliff
    Laboratory of Neurochemistry, Indiana University School of Medicine, Evansville 47712, USA
    J Enzyme Inhib 9:309-16. 1995
  9. ncbi request reprint Sites of action of gamma-hydroxybutyrate (GHB)--a neuroactive drug with abuse potential
    G Tunnicliff
    Indiana University, School of Medicine, Evansville 47712, USA
    J Toxicol Clin Toxicol 35:581-90. 1997
  10. ncbi request reprint Basis of the antiseizure action of phenytoin
    G Tunnicliff
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Evansville 47712, USA
    Gen Pharmacol 27:1091-7. 1996

Research Grants

  1. Mechanisms of Signal Transduction of GHB Action
    Godfrey Tunnicliff; Fiscal Year: 2002
  2. Submissive Behavior as a Model of Depression
    Godfrey Tunnicliff; Fiscal Year: 2002

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Gamma-Hydroxybutyrate (orphan medical)
    Godfrey Tunnicliff
    Indiana University School of Medicine, Evansville 47712, USA
    Curr Opin Investig Drugs 3:278-83. 2002
    ..GHB occurs naturally in many human tissues. It has previously been used in the treatment of narcolepsy and is not patentable for that indication...
  2. ncbi request reprint Central GABAergic systems and depressive illness
    G Tunnicliff
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, 8600 University Boulevard, Evansville, Indiana 47712, USA
    Neurochem Res 28:965-76. 2003
    ..Most of the data from direct and indirect studies are consistent with GABA involvement in depression...
  3. ncbi request reprint Action of 4-amino-2-fluorobutanoic acid and other structural analogues on gamma-aminobutyric acid transport by channel catfish brain
    Glenda J Crites
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Evansville, IN 47712, USA
    J Basic Clin Physiol Pharmacol 13:179-92. 2002
    ..4 microM) inhibited noncompetitively. Other analogues exhibited competitive inhibition. These observations suggest that the GABA transport system in channel catfish is remarkably similar to that in mammalian brain...
  4. ncbi request reprint Membrane glycine transport proteins
    Godfrey Tunnicliff
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Evansville, Ind 47712, USA
    J Biomed Sci 10:30-6. 2003
    ..This is known as the vesicular inhibitory amino acid transporter since, in addition to glycine, it can transport possibly two other inhibitory neurotransmitters...
  5. ncbi request reprint Pharmacology and function of imidazole 4-acetic acid in brain
    G Tunnicliff
    Laboratory of Neurochemistry, Indiana University School of Medicine, Evansville 47712, USA
    Gen Pharmacol 31:503-9. 1998
    ..No specific receptor site or uptake system for IMA has yet been discovered, adding uncertainty to its role in central nervous system function. Yet the possibility cannot be overlooked that IMA plays a role in regulating blood pressure...
  6. ncbi request reprint The GABA(A) receptor complex as a target for fluoxetine action
    G Tunnicliff
    Department of Biochemistry, Indiana University School of Medicine, Evansville 47712, USA
    Neurochem Res 24:1271-6. 1999
    ..These observations might assist in an explanation of the basis of the antidepressant action of fluoxetine...
  7. ncbi request reprint Effects of treatment with GABA(A) receptor subunit antisense oligodeoxynucleotides on GABA-stimulated 36Cl- influx in the rat cerebral cortex
    E Malatynska
    Department of Pharmacology and Toxicology, Indiana University, School of Medicine, Evansville 47712, USA
    Neurochem Int 36:45-54. 2000
    ....
  8. ncbi request reprint Chemical modification of bacterial 4-aminobutyrate aminotransferase by phenylglyoxal
    G Tunnicliff
    Laboratory of Neurochemistry, Indiana University School of Medicine, Evansville 47712, USA
    J Enzyme Inhib 9:309-16. 1995
    ..The data are consistent with the modification of amino acid residues at the cofactor binding site on the enzyme...
  9. ncbi request reprint Sites of action of gamma-hydroxybutyrate (GHB)--a neuroactive drug with abuse potential
    G Tunnicliff
    Indiana University, School of Medicine, Evansville 47712, USA
    J Toxicol Clin Toxicol 35:581-90. 1997
    ..GHB is derived from gamma-aminobutyric acid (GABA) and is proposed to function as an inhibitory chemical transmitter in the central nervous system...
  10. ncbi request reprint Basis of the antiseizure action of phenytoin
    G Tunnicliff
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Evansville 47712, USA
    Gen Pharmacol 27:1091-7. 1996
    ..Moreover, the fact that phenytoin also has important cardiac antiarrhythymic effects and can inhibit Na+ influx into cardiac cells supports the idea that the primary target of phenytoin is, indeed, the Na+ channel...
  11. ncbi request reprint Effects of repeated doses of azapirones on rat brain 5-HT1A receptors and plasma corticosterone levels
    G K Matheson
    Department of Anatomy, Indiana University School of Medicine, Evansville 47712, USA
    Gen Pharmacol 27:355-61. 1996
    ....
  12. ncbi request reprint Kinetics of inactivation of glutamate decarboxylase by cysteine-specific reagents
    S J McCormick
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Evansville, IN 47712, USA
    Acta Biochim Pol 48:573-8. 2001
    ..The characteristics of the inhibition by the three thiol-group reagents supports the idea that cysteinyl residues at the binding sites for the cofactor and/or the substrate are important for enzyme activity in E. coli...
  13. ncbi request reprint Kinetics of binding of [(3)H]glycine to transport proteins in channel catfish brain
    Rebeca A Achterhof
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Evansville, IN 47712, USA
    Neurosignals 11:67-72. 2002
    ..The present results suggest that the binding of [(3)H]glycine was to a glycine transporter and that the amino acid functions as a neurotransmitter in this species...
  14. ncbi request reprint The teaching of complementary and alternative medicine in U.S. medical schools: a survey of course directors
    James J Brokaw
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, 46202 5120, USA
    Acad Med 77:876-81. 2002
    ..This study gauged the current state of CAM instruction by gathering details about the specific topics being taught and the objectives behind the instruction...
  15. ncbi request reprint Irreversible inhibition of [3H]glycine transport into channel catfish erythrocytes by thiol group modifiers
    Sara J McCormick
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Evansville, IN 47712, USA
    Pharmacology 70:113-7. 2004
    ..Thus cysteinyl residues within the transport protein appear to be vital for the binding and uptake of glycine by channel catfish erythrocytes...
  16. ncbi request reprint Status of complementary and alternative medicine in the osteopathic medical school curriculum
    Dale W Saxon
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Evansville, USA
    J Am Osteopath Assoc 104:121-6. 2004
    ....
  17. ncbi request reprint Submissive behavior in mice as a test for antidepressant drug activity
    Ewa Malatynska
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, Evansville, IN, USA
    Pharmacol Biochem Behav 82:306-13. 2005
    ..We conclude that like the rat model of depression from which it was developed, the mouse model responds to various antidepressants as predicted and thus may serve as a potential model of clinical depression...

Research Grants2

  1. Mechanisms of Signal Transduction of GHB Action
    Godfrey Tunnicliff; Fiscal Year: 2002
    ..In turn, this will help to develop therapeutic and preventive strategies resulting in a lessened abuse potential of GHB. ..
  2. Submissive Behavior as a Model of Depression
    Godfrey Tunnicliff; Fiscal Year: 2002
    ..The identification of genetic elements in mice associated with depression-like behavior can be tested for homology in human patients that could ultimately lead to an understanding of genetic defects underlying depression in humans. ..