Research Topics
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Publications
Plasma levels of prorenin and renin in blacks and whites: their relative abundance and associations with plasma aldosterone concentrationWanzhu Tu
Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
Am J Hypertens 25:1030-4. 2012..We sought to determine whether prorenin levels were related to extracellular volume, as reflected by the levels of plasma renin activity (PRA), and to aldosterone...
Intensified effect of adiposity on blood pressure in overweight and obese childrenWanzhu Tu
Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Hypertension 58:818-24. 2011..The findings have relevance to interventions designed to prevent or treat adiposity-related increases in BP and to the analytic approaches used in epidemiological studies...
Time from first intercourse to first sexually transmitted infection diagnosis among adolescent womenWanzhu Tu
Department of Medicine, Indiana University School of Medicine, Indianapolis, 46202, USA
Arch Pediatr Adolesc Med 163:1106-11. 2009..To determine the time between first intercourse and first sexually transmitted infection (STI) with Chlamydia trachomatis, Neisseria gonorrhoeae, or Trichomonas vaginalis and time between repeated infections...
Somatic symptoms in patients with cancer experiencing pain or depression: prevalence, disability, and health care useKurt Kroenke
Richard Roudebush VA Medical Center, Indianapolis, USA
Arch Intern Med 170:1686-94. 2010..The adverse impact of a high somatic symptom burden is well established for primary care and other noncancer populations with chronic medical disorders...
Correlates of health-related quality of life among lower-income, urban adults with congestive heart failureDaniel O Clark
Indiana University Center for Aging Research, Indianapolis, 46202, USA
Heart Lung 32:391-401. 2003..Variance explained ranged from 14 to 33%. CONCLUSION: These cross-sectional data highlight the potential significance of social and behavioral factors in CHF-specific HRQL...
Effect of telecare management on pain and depression in patients with cancer: a randomized trialKurt Kroenke
Center for Implementing Evidence Based Practice, Richard Roudebush VA Medical Center, Indianapolis, IN, USA
JAMA 304:163-71. 2010..Pain and depression are 2 of the most prevalent and treatable cancer-related symptoms, yet they frequently go unrecognized, undertreated, or both...
The association of depression and pain with health-related quality of life, disability, and health care use in cancer patientsKurt Kroenke
Regenstrief Institute, Inc, 1050 Wishard Blvd, 6th Floor, Indianapolis, IN 46202, USA
J Pain Symptom Manage 40:327-41. 2010..Pain and depression are two of the most prevalent and treatable cancer-related symptoms, each present in at least 20%-30% of oncology patients...
Patient perception and provider assessment of severity of heart failure as predictors of hospitalizationUsha Subramanian
Roudebush Veterans Administration Medical Center, Indianapolis, Indiana 46202, USA
Heart Lung 34:89-98. 2005..A different approach with patients may be needed if providers hope to use patients' reports to identify those at risk for hospitalization...
Association of condom use, sexual behaviors, and sexually transmitted infections with the duration of genital human papillomavirus infection among adolescent womenMarcia L Shew
Division of Adolescent Medicine, Department of Pediatrics, Indiana University School of Medicine, 545 Barnhill Drive, Indianapolis, IN 46202, USA
Arch Pediatr Adolesc Med 160:151-6. 2006..30]). CONCLUSIONS: These findings support public health messages of reducing the number of sexual partners, promoting routine condom use, and frequent sexually transmitted infection screening that may be beneficial with HPV infections...
Optimized antidepressant therapy and pain self-management in primary care patients with depression and musculoskeletal pain: a randomized controlled trialKurt Kroenke
Division of General Internal Medicine and Geriatrics, Indiana University School of Medicine, Indianapolis, USA
JAMA 301:2099-110. 2009..Pain and depression are the most common physical and psychological symptoms in primary care, respectively. Moreover, they co-occur 30% to 50% of the time and have adverse effects on quality of life, disability, and health care costs...
The influence of hormonal contraception on mood and sexual interest among adolescentsMary A Ott
Section of Adolescent Medicine, Department of Pediatrics, Indiana University, 410 West 10th Street, HS1001, Indianapolis, IN 46202, USA
Arch Sex Behav 37:605-13. 2008..Changes in mood among adolescent hormonal contraceptive users differed from those anticipated for adult users. Attention to adolescent-specific changes in mood and sexual interest may improve contraceptive adherence...
A semi-parametric threshold regression analysis of sexually transmitted infections in adolescent womenZhangsheng Yu
Division of Biostatistics, Indiana University School of Medicine, Indianapolis, IN 46254, USA
Stat Med 28:3029-42. 2009..Analysis shows that the lifetime number of sexual partners has a nonlinear effect on the risk of C. trachomatis infection and the infection risks were differential by ethnicity and age of sexual debut...
Cost analysis of the Geriatric Resources for Assessment and Care of Elders care management interventionSteven R Counsell
Center for Aging Research, School of Medicine, Indiana University, Indianapolis, Indiana 46202, USA
J Am Geriatr Soc 57:1420-6. 2009..To provide, from the healthcare delivery system perspective, a cost analysis of the Geriatric Resources for Assessment and Care of Elders (GRACE) intervention, which is effective in improving quality of care and outcomes...
Geriatric care management for low-income seniors: a randomized controlled trialSteven R Counsell
Indiana University Center for Aging Research, Indiana University School of Medicine, Indianapolis, Indianapolis, IN 46202, USA
JAMA 298:2623-33. 2007..Low-income seniors frequently have multiple chronic medical conditions for which they often fail to receive the recommended standard of care...
Care management of poststroke depression: a randomized, controlled trialLinda S Williams
Roudebush VA Medical Center, Indianapolis, IN 46202, USA
Stroke 38:998-1003. 2007..Our objective was to determine the effectiveness of the Activate-Initiate-Monitor care management program for the treatment of poststroke depression...
Repeated Chlamydia trachomatis genital infections in adolescent womenByron E Batteiger
Divisions of Infectious Diseases, Indiana University School of Medicine, Indianapolis, Indiana 46202 5112, USA
J Infect Dis 201:42-51. 2010..Repeated Chlamydia trachomatis infections are common among young sexually active women. The relative frequency of reinfection and antibiotic treatment failure is undefined...
The association of depression and anxiety with health-related quality of life in cancer patients with depression and/or painLinda F Brown
Department of Psychology, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202, USA
Psychooncology 19:734-41. 2010..Because the disorders are highly comorbid, we examined the relationship of anxiety and depression with health-related quality of life (HRQL) in cancer patients...
Predictors of pain outcomes in patients with chronic musculoskeletal pain co-morbid with depression: results from a randomized controlled trialDennis C Ang
Division of Rheumatology, Department of Medicine, Indiana University School of Medicine, IN 46202, USA
Pain Med 11:482-91. 2010..In this study, we report the predictors of pain intensity and activity interference in primary care patients with co-morbid pain and depression...
The impact of delinquency on young adult sexual risk behaviors and sexually transmitted infectionsMatthew C Aalsma
Section of Adolescent Medicine, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
J Adolesc Health 46:17-24. 2010..Therefore, we used nationally representative data to examine the longitudinal association between delinquent behavior, sexual risk behavior, and STI among adolescents and young adults...
Characteristics associated with sex after periods of abstinence among sexually experienced young womenMary A Ott
Section of Adolescent Medicine, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, USA
Perspect Sex Reprod Health 42:43-8. 2010..Adolescent pregnancy prevention is difficult because adolescent sex is intermittent. Understanding why sexually experienced adolescents have sex after a period of abstinence will help clinicians to tailor counseling...
Predictors of herpes simplex virus type 2 antibody positivity among persons with no history of genital herpesKenneth H Fife
Department of Medicine, Indiana University School of Medicine, Indianapolis 46202, USA
Sex Transm Dis 31:676-81. 2004..The demographic, historical, and behavioral factors that predict a positive herpes simplex virus type 2 (HSV-2) antibody test in persons without a history of genital herpes have not been well-defined...
Web-based training in geriatrics for medical residents: a randomized controlled trial using standardized patients to assess outcomesGlenda R Westmoreland
Department of Medicine, Indiana University, Indianapolis, Indiana, USA
J Am Geriatr Soc 58:1163-9. 2010..More-intensive educational interventions are needed to improve clinical performance by trainees in the care of older patients...
Longitudinal associations among relationship factors, partner change, and sexually transmitted infection acquisition in adolescent womenMary A Ott
Section of Adolescent Medicine, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Sex Transm Dis 38:153-7. 2011..We prospectively examined associations between relationship characteristics, partner change, and subsequent STI during intervals of "serial monogamy."..
Comparative responsiveness of pain outcome measures among primary care patients with musculoskeletal painErin E Krebs
Center on Implementing Evidence Based Practice, Roudebush VA Medical Center, Indianapolis, IN 46202, USA
Med Care 48:1007-14. 2010..Comparative responsiveness data are needed to inform choices about pain outcome measures...
The Indiana Cancer Pain and Depression (INCPAD) trial Design of a telecare management intervention for cancer-related symptoms and baseline characteristics of study participantsKurt Kroenke
Department of Medicine, Indiana University, Indianapolis, IN 46202, USA
Gen Hosp Psychiatry 31:240-53. 2009..This article describes a telecare management intervention delivered by a nurse-psychiatrist team that is designed to improve recognition and treatment of pain and depression. The enrolled sample is also described...
Patterns of oral contraceptive pill-taking and condom use among adolescent contraceptive pill usersJennifer L Woods
Section of Adolescent Medicine, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA
J Adolesc Health 39:381-7. 2006..The purpose of this study was to describe daily adherence patterns of OCP use, to analyze OCP protection on an event level basis, and to examine pill-taking and condom use during method transitions...
Return for results after herpes simplex virus type 2 screeningJ Dennis Fortenberry
Indiana University School of Medicine, Indianapolis, USA
Sex Transm Dis 31:655-8. 2004..The objective of this study was to evaluate factors associated with return for results of type-specific herpes simplex virus (HSV) screening...
Factors predicting the acceptance of herpes simplex virus type 2 antibody testing among adolescents and young adultsGregory D Zimet
Department of Pediatrics, Indiana University School of Medicine, Indianapolis, USA
Sex Transm Dis 31:665-9. 2004..The rates and determinants of acceptance of herpes simplex virus type 2 (HSV-2) testing have not been adequately studied...
A longitudinal study of genital human papillomavirus infection in a cohort of closely followed adolescent womenDarron R Brown
Division of Infectious Diseases, Indiana University School of Medicine, 545 Barnhill Dr, Emerson Hall, Rm 435, Indianapolis, IN 46202, USA
J Infect Dis 191:182-92. 2005..We performed a study to better characterize the natural history of genital human papillomavirus (HPV) infection in a cohort of closely followed adolescent women...
Performance of the PHQ-9 as a screening tool for depression after strokeLinda S Williams
Roudebush VAMC HSR and D 11 H, 1481 W 10 Street, Indianapolis, IN 46202, USA
Stroke 36:635-8. 2005..The purpose of this study was to examine the performance of the Patient Health Questionnaire (PHQ)-9, a 9-item depression scale, as a screening and diagnostic instrument for assessing depression in stroke survivors...
The prevalence of chlamydia, gonorrhea, and trichomonas in sexual partnerships: implications for partner notification and treatmentAyesha Khan
Division of Infectious Diseases, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Sex Transm Dis 32:260-4. 2005..However, limited data exists regarding STIs within sexual partnerships (dyads)...
The effects of health and environment on exercise-class participation in older, urban womenWanzhu Tu
Indiana University Center for Aging Research, Regenstrief Institute, Inc, Indianapolis, IN 46202, USA
J Aging Phys Act 12:480-96. 2004..This research highlights the need to better understand environmental barriers when promoting physical activities in older women...
Daily mood, partner support, sexual interest, and sexual activity among adolescent womenJ Dennis Fortenberry
Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202 5205, USA
Health Psychol 24:252-7. 2005..The findings extend understanding of the sexuality of adolescent women and have implications for a variety of interventions to reduce sexually transmitted infections and unplanned pregnancies...
Condom use as a function of time in new and established adolescent sexual relationshipsJ Dennis Fortenberry
Section of Adolescent Medicine, Division of Biostatistics, and the Regenstrief Institute for Health Care, Indiana University School of Medicine, Indianapolis, USA
Am J Public Health 92:211-3. 2002..This study sought to describe condom use over time in new and established adolescent relationships...
Factors associated with time of day of sexual activity among adolescent womenJ Dennis Fortenberry
Department of Pediatrics, Mid America Adolescent STD Cooperative Research Center, Indianapolis, Indiana, USA
J Adolesc Health 38:275-81. 2006..Our objective was to describe familial, intrapersonal, and partner-related factors associated with time of day of sexual activity among adolescent women...
Incidence and correlates of unwanted sex in relationships of middle and late adolescent womenMargaret J Blythe
Department of Pediatrics, University Medical Center, Indiana University School of Medicine, 1001 W 10th Street, Indianapolis, IN 46202, USA
Arch Pediatr Adolesc Med 160:591-5. 2006..To determine the 3-month incidence of unwanted sex and to examine relationship factors and health-risk behaviors associated with incident unwanted sex...
How valid are family proxy assessments of stroke patients' health-related quality of life?Linda S Williams
Health Services Research and Development Service, Roudebush VAMC, 1481 W 10th St, 11 H, Indianapolis, Indiana 46202, USA
Stroke 37:2081-5. 2006..The magnitude of this difference, the degree of agreement between patients and proxies, and the factors influencing agreement are not well known...
Somatic symptoms in primary care: etiology and outcomeAdnan A Khan
Department of Medicine and Regenstrief Institute, Indiana University School of Medicine, Indianapolis 46202, USA
Psychosomatics 44:471-8. 2003..e., seven or more medical diagnoses). Developing better management strategies for prevalent, medically unexplained, persistent somatic symptoms is a health care priority...
Association between adherence measurements of metoprolol and health care utilization in older patients with heart failureWanzhu Tu
Department of Medicine, Indiana University School of Medicine, Indiannapolis, USA
Clin Pharmacol Ther 77:189-201. 2005..The potential utility of these measures for other beta-adrenergic antagonists and perhaps other cardiovascular drugs should be investigated...
Synchronization of adolescent blood pressure and pubertal somatic growthWanzhu Tu
Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
J Clin Endocrinol Metab 94:5019-22. 2009..Blood pressure (BP) and growth increase at an accelerated rate during puberty. The temporal relationship of the two events has not been well characterized...
Studies of an association in boys of blood pressure and the Y chromosomeR Ravi Shankar
Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Am J Hypertens 20:27-31. 2007..In the current study, we examined the association of a HindIII restriction site on the Y chromosome with BP in a cohort of young men...
The change in blood pressure during pubertal growthR Ravi Shankar
Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana 46202-5111, USA
J Clin Endocrinol Metab 90:163-7. 2005..In summary, PG was associated with profound increases in systolic BP. There were noticeably greater increments in males than in females consistent with the emergence of the well known sexual dimorphism in BP...
Estimation of survival functions in interval and right censored data using STD behavioural diariesJaroslaw Harezlak
Department of Biostatistics, Harvard University School of Public Health, USA
Stat Med 25:4053-64. 2006..We illustrate this method by analysing infection data obtained from an ongoing STD investigation of adolescent females...
Pharmacist intervention to improve medication adherence in heart failure: a randomized trialMichael D Murray
Center for Pharmaceutical Outcomes and Policy, University of North Carolina School of Pharmacy, Chapel Hill, North Carolina 27599 7360, USA
Ann Intern Med 146:714-25. 2007..Patients with heart failure who take several prescription medications sometimes have poor adherence to their treatment regimens. Few interventions designed to improve adherence to therapy have been rigorously tested...
A conceptual framework to study medication adherence in older adultsMichael D Murray
Department of Pharmacy Practice, Purdue University School of Pharmacy, West Lafayette, Indiana, USA
Am J Geriatr Pharmacother 2:36-43. 2004..Adults aged > or =50 years often have multiple chronic diseases requiring multiple medications. However, even drugs with well-documented benefits are often not taken as prescribed, for a variety of reasons...
Association of medication adherence, knowledge, and skills with emergency department visits by adults 50 years or older with congestive heart failureCarol J Hope
School of Medicine, University of Mississippi Medical Center, Jackson, USA
Am J Health Syst Pharm 61:2043-9. 2004..001). CONCLUSION: Greater medication knowledge, skills, and adherence were associated with fewer ED visits among patients 50 years of age or older with CHF in an urban, teaching medical center...
Association of refill adherence and health care use among adults with hypertension in an urban health care systemKevin T Stroupe
Midwest Center for Health Services and Policy Research, Hines Veterans Affairs Hospital, Hines 60141 5151, and the Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
Pharmacotherapy 26:779-89. 2006..e., patients who have and have not, respectively, experienced hypertension-related target organ damage), and to examine the association of refill adherence with hospitalization and health care costs among these patients...
Correlates of health literacy in patients with chronic heart failureDan Morrow
Beckman Institute of Advanced Science and Technology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
Gerontologist 46:669-76. 2006..We investigated relationships between health literacy and general cognitive and sensory abilities, as well as education, health, and demographic variables, in a community sample of middle-aged and older adults...
Association between adherence to diuretic therapy and health care utilization in patients with heart failureMichelle A Chui
Midwestern University College of Pharmacy-Glendale, Glendale, Arizona, USA
Pharmacotherapy 23:326-32. 2003..If these findings are confirmed by a larger study, interventions to improve adherence and patient health outcomes should consider the timing of doses as well as the number of daily doses of a diuretic...
Methodology of an ongoing, randomized, controlled trial to improve drug use for elderly patients with chronic heart failureMichael D Murray
Department of Pharmacy Practice, Purdue University School of Pharmacy, West Lafayette, Indiana, USA
Am J Geriatr Pharmacother 2:53-65. 2004..However, patients may not adhere to therapy. Patients with complex medication regimens and low health literacy are at risk for nonadherence...
Research Grants
- Statistical Tools For Daily STD/HIV Behavioral ReportsWanzhu Tu; Fiscal Year: 2006....
- Effects of Somatic Growth and Sodium Retention on Blood PressureWANZHU contact TU; Fiscal Year: 2010..Its public health relevance is that it may facilitate the identification of somatic growth patterns that signal future risk of hypertension. ..
