Research Topics
| A Joseph TectorSummaryAffiliation: Indiana University Country: USA Publications
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Publications
Aberrations in hemostasis and coagulation in untreated discordant hepatic xenotransplantation: studies in the dog-to-pig modelA Joseph Tector
Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Liver Transpl 8:153-9. 2002..In brief, the hemorrhage that accompanies liver xenotransplantation occurs because of a decrease in the number and function of circulating platelets in the recipient...- Promising early results with immunosuppression using rabbit anti-thymocyte globulin and steroids with delayed introduction of tacrolimus in adult liver transplant recipientsA Joseph Tector
Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Liver Transpl 10:404-7. 2004..RATG induction therapy is associated with good patient and graft survival, a low incidence of rejection, and minimal side effects. In addition, RATG induction is safe in patients transplanted for HCV... 
Use of extended criteria livers decreases wait time for liver transplantation without adversely impacting posttransplant survivalA Joseph Tector
Department of Surgery, Transplantation Section, Gastroenterology Division, Indiana University School of Medicine, Indianapolis, IN 46202 5250, USA
Ann Surg 244:439-50. 2006..This study compares the graft/patient survival from standard (SD) and ECD for our transplant population between 2001 and 2005...
Immortalized porcine liver sinusoidal endothelial cells: an in vitro model of xenotransplantation-induced thrombocytopeniaZheng Yu Wang
Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
Xenotransplantation 19:249-55. 2012..Porcine iLSEC would enable continued study of xenotransplantation-induced thrombocytopenia in vitro with fewer animals sacrificed...- Differences in human and porcine platelet oligosaccharides may influence phagocytosis by liver sinusoidal cells in vitroLeela L Paris
Xenoimmunology Laboratory, Department of Surgery, Transplant Institute, Indiana University School of Medicine, Indiana University Health, Indianapolis, IN 46202, USA
Xenotransplantation 19:31-9. 2012..Analysis of these receptor carbohydrate-binding domains and surface carbohydrates on human and porcine platelets may shed light on the mechanism of xenotransplantation-induced thrombocytopenia... - Utility of liver function tests including aminotransferase-to-platelet ratio index in monitoring liver dysfunction in short-gut infants of varying ages and intestinal lengthsMICHAEL O'CONNOR
Transplant Division, Department of Surgery, Indiana University, School of Medicine, Indianapolis, IN 46202, USA
J Pediatr Surg 46:1057-63. 2011..This study applies laboratory liver function testing, including APRI, to monitor liver dysfunction over time for short-gut infants, with further analysis of at-risk subpopulations... - No difference in clinical transplant outcomes for local and imported liver allograftsRichard S Mangus
Clarian Transplant Institute, Indiana University School of Medicine, Indianapolis, IN 46202 5250, USA
Liver Transpl 15:640-7. 2009..In conclusion, liver allografts rejected for use by a large number of transplant centers can still be successfully used without early graft function or long-term survival being affected... - Primary porcine Kupffer cell phagocytosis of human platelets involves the CD18 receptorRay K Chihara
Department of Surgery, Indiana University Transplant Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Transplantation 92:739-44. 2011..We sought to identify the role of KC CD18 in liver xenograft-induced thrombocytopenia... - ASGR1 expressed by porcine enriched liver sinusoidal endothelial cells mediates human platelet phagocytosis in vitroLeela L Paris
Department of Surgery, Indiana University School of Medicine, IU Health Transplant Institute, Indianapolis, IN 46202, USA
Xenotransplantation 18:245-51. 2011..Recently, it was discovered that porcine liver sinusoidal endothelial cells (LSEC) bind and phagocytose human platelets. We examined the role of ASGR1 in binding and removing human platelets by the pig liver endothelium... - Use of the aspartate aminotransferase to platelet ratio index to follow liver fibrosis progression in infants with short gutRichard S Mangus
Department of Surgery, Transplant Section, Indiana University School of Medicine, Indianapolis, IN 46202 5250, USA
J Pediatr Surg 45:1266-73. 2010..This study applies APRI scoring to parenteral nutrition-dependant, short-gut infants to determine hepatic fibrosis progression... - Double knockout pigs deficient in N-glycolylneuraminic acid and Galactose α-1,3-Galactose reduce the humoral barrier to xenotransplantationAndrew J Lutz
Department of Surgery, IU Health Transplant Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Xenotransplantation 20:27-35. 2013..Clinical xenotransplantation is not possible because humans possess antibodies that recognize antigens on the surface of pig cells. Galα-1,3-Gal (Gal) and N-glycolylneuraminic acid (Neu5Gc) are two known xenoantigens... - Immunosuppression induction with rabbit anti-thymocyte globulin with or without rituximab in 1000 liver transplant patients with long-term follow-upRichard S Mangus
Transplant Division, Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202 5250, USA
Liver Transpl 18:786-95. 2012..05), and DCD (HR = 1.55, P = 0.11). rATG-based induction immunosuppression can be safely used in adult LT recipients with excellent survival and low rejection rates and without increases in immunosuppression-related side effects... - Induction immunosuppression with rabbit antithymocyte globulin in pediatric liver transplantationAshesh Shah
Surgery, Indiana University, Indianapolis, IN, USA
Liver Transpl 12:1210-4. 2006..In conclusion, our data suggest that RATG induction with steroid and tacrolimus maintenance therapy is safe, easy to use, and effective in the prevention of rejection... - Severe hypernatremia in deceased liver donors does not impact early transplant outcomeRichard S Mangus
Department of Surgery, Transplantation Section, Indiana University School of Medicine, Indianapolis, IN, USA
Transplantation 90:438-43. 2010..The purported mechanism for this effect is undefined. This study analyzes early graft function for donor livers procured from patients with severe hypernatremia... - Outcomes of pancreas allografts procured simultaneously with an isolated intestine allograft: single-center and national dataJonathan A Fridell
Department of Surgery, Indiana University School of Medicine, 550 N University Blvd 4258, Indianapolis, IN 46202, USA
Transplantation 94:84-8. 2012..This study reports the transplant outcomes for pancreas allografts procured simultaneously with an intestine graft... - Safe inclusion of the entire pancreas as a component of the multivisceral graftRodrigo Vianna
Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Transplantation 86:114-6. 2008..We reviewed our experience with multivisceral grafts that included the entire pancreas... - Steroid withdrawal for pancreas after kidney transplantation in recipients on maintenance prednisone immunosuppressionJonathan A Fridell
Department of Surgery, Indiana University School of Medicine, Indianapolis, 46202, USA
Transplantation 82:389-92. 2006.... - Current status of small bowel and multivisceral transplantationRodrigo M Vianna
Intestinal and Multivisceral Transplantation, Transplant Surgery Section, Indiana University School of Medicine, Indiana University Hospital 4601, 550 N University Blvd, Indianapolis, IN 46202, USA
Adv Surg 42:129-50. 2008..Early referral for isolated intestinal transplant will reduce the need for simultaneous multiorgan transplants and increase the residual organs available for patients in need of (primarily) liver transplantation... - Comparison of histidine-tryptophan-ketoglutarate solution and University of Wisconsin solution in extended criteria liver donorsRichard S Mangus
Department of Surgery, Transplantation Section, Indiana University School of Medicine, Indianapolis, IN 46202 5250, USA
Liver Transpl 14:365-73. 2008..These findings persisted for both SCD and ECD livers. Given the lower cost per donor for HTK, this preservation solution may be preferable for general use... - Comparison of histidine-tryptophan-ketoglutarate solution (HTK) and University of Wisconsin solution (UW) in adult liver transplantationRichard S Mangus
Department of Surgery, Transplantation Section, Indiana University School of Medicine, Indianapolis, IN 46202-5250, USA
Liver Transpl 12:226-30. 2006..There were no significant differences between HTK and UW in this population when comparing 1 month graft function and first-year graft and patient survival... - Identification of human preformed antibody targets in GTKO pigsChristopher Burlak
Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Xenotransplantation 19:92-101. 2012..This study examined the potential reactivity of human preformed IgG and IgM antibodies toward antigens in the GTKO pig liver... - Multivisceral transplantation for diffuse portomesenteric thrombosisRodrigo M Vianna
Department of Surgery, Division of Transplantation, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Ann Surg 255:1144-50. 2012..To evaluate the clinical outcomes of multivisceral transplantation (MVT) in the setting of diffuse thrombosis of the portomesenteric venous system... - Evaluation of response after stereotactic body radiotherapy for hepatocellular carcinomaTracy R Price
Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Cancer 118:3191-8. 2012..Stereotactic body radiotherapy (SBRT) is a noninvasive, effective therapy in the management of liver malignancies. The authors evaluated radiological response in 26 patients with HCC treated with SBRT at Indiana University... - Stereotactic body radiotherapy for primary hepatocellular carcinomaDavid L Andolino
Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Int J Radiat Oncol Biol Phys 81:e447-53. 2011..To evaluate the safety and efficacy of stereotactic body radiotherapy (SBRT) for the treatment of primary hepatocellular carcinoma (HCC)... - Intravenous interferon during the anhepatic phase of liver retransplantation and prevention of recurrence of cholestatic hepatitis C virusPaul Y Kwo
Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202 5121, USA
Liver Transpl 13:1710-3. 2007..The role of anhepatic administration of interferon deserves further examination, and this combination may provide a solution in a subset of patients with an otherwise poor prognosis... - Post-transplant critical care outcomes for pediatric multivisceral and intestinal transplant patientsCourtney M Rowan
Department of Pediatric Pulmonary, Critical Care and Allergy, Riley Hospital for Children, Indiana University Health, Indianapolis, IN 46202 5225, USA
Pediatr Transplant 16:788-95. 2012.... - Biallelic knockout of the α-1,3 galactosyltransferase gene in porcine liver-derived cells using zinc finger nucleasesPing Li
Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
J Surg Res 181:e39-45. 2013..ZFN-treated LDC were used as nuclear donors to produce fetuses and piglets via SCNT. All cloned fetuses and piglets showed biallelic knockout of GGTA1 gene... - Multivisceral transplantation: expanding indications and improving outcomesRichard S Mangus
Transplant Division, Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
J Gastrointest Surg 17:179-86; discussion p.186-7. 2013..This study reviews the changing indications and outcomes for this procedure over a 7-year period at a university medical center... - Gene targeting and cloning in pigs using fetal liver derived cellsSanjeev K Waghmare
Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
J Surg Res 171:e223-9. 2011..The goal of this study was to test the feasibility of using fetal liver-derived cells (FLDC) to perform gene targeting, and create a genetic knockout pig... - The fate of human platelets perfused through the pig liver: implications for xenotransplantationChristopher Burlak
Department of Surgery, Clarian Transplant Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Xenotransplantation 17:350-61. 2010..Studies in pig and baboon liver xenografts revealed the main obstacle to be a lethal thrombocytopenia that occurred within minutes to hours of transplantation... - Epidemiology of acute liver failureMouen Khashab
Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, 675 West Walnut, IB 327, Indianapolis, IN 46202, USA
Curr Gastroenterol Rep 9:66-73. 2007..Liver support systems show potential for the treatment of ALF, but their role needs validation in large multicenter randomized trials... - Portal versus systemic drainage of small bowel allografts: comparative assessment of survival, function, rejection, and bacterial translocationThierry Berney
Liver/Gastrointestinal Transplantation, Department of Surgery, University of Miami School of Medicine, Miami, FL 33136, USA
J Am Coll Surg 195:804-13. 2002..But attention should be paid to an impaired clearance of intestinal bacterial translocation after systemic drainage... - Clinical lung xenotransplantation--what donor genetic modifications may be necessary?David K C Cooper
Thomas E Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA
Xenotransplantation 19:144-58. 2012..The optimistic view would be that if experimental pig lung xenotransplantation could be successfully managed, it is likely that clinical application of this and all other forms of xenotransplantation would become more feasible... - Laparoscopic incisional hernia repair after solid-organ transplantationPeter T Kennealey
Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Arch Surg 144:228-33; discussion 233. 2009..Laparoscopic incisional hernia repair (LIHR) is efficacious in transplant recipients... - Hepatic sinusoidal endothelium upregulates IL-1alpha, IFN-gamma, and iNOS in response to discordant xenogeneic islets in an in vitro model of xenoislet transplantationMichael Tan
Department of Surgery, McGill University Health Centre, Montreal, Canada
J Surg Res 102:229-36. 2002..Our findings suggest that host endothelium may play an important part in early injury of islet xenotransplants...