A Joseph Tector

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. ncbi request reprint Aberrations in hemostasis and coagulation in untreated discordant hepatic xenotransplantation: studies in the dog-to-pig model
    A Joseph Tector
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Liver Transpl 8:153-9. 2002
  2. ncbi request reprint Promising early results with immunosuppression using rabbit anti-thymocyte globulin and steroids with delayed introduction of tacrolimus in adult liver transplant recipients
    A Joseph Tector
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Liver Transpl 10:404-7. 2004
  3. pmc Use of extended criteria livers decreases wait time for liver transplantation without adversely impacting posttransplant survival
    A Joseph Tector
    Department of Surgery, Transplantation Section, Gastroenterology Division, Indiana University School of Medicine, Indianapolis, IN 46202 5250, USA
    Ann Surg 244:439-50. 2006
  4. ncbi request reprint Crossmatch-positive liver transplantation in patients receiving thymoglobulin-rituximab induction
    Chandrashekhar A Kubal
    1 Transplant Division, Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 2 Department of Pathology, Indiana University School of Medicine, Indianapolis, IN 3 Transplant Immunology Laboratory, Methodist Hospital, Indiana University School of Medicine, Indianapolis, IN 4 Transplant Division, Department of Surgery, University of Virginia, Charlottesville, VA 5 Address correspondence to Chandrashekhar A Kubal, M D, Ph D, Transplant Division, Department of Surgery, Indiana University School of Medicine, 550 North University Boulevard, Room 4601, Indianapolis, IN
    Transplantation 97:56-63. 2014
  5. doi request reprint Immortalized porcine liver sinusoidal endothelial cells: an in vitro model of xenotransplantation-induced thrombocytopenia
    Zheng Yu Wang
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
    Xenotransplantation 19:249-55. 2012
  6. doi request reprint Differences in human and porcine platelet oligosaccharides may influence phagocytosis by liver sinusoidal cells in vitro
    Leela L Paris
    Xenoimmunology Laboratory, Department of Surgery, Transplant Institute, Indiana University School of Medicine, Indiana University Health, Indianapolis, IN 46202, USA
    Xenotransplantation 19:31-9. 2012
  7. doi request reprint Utility of liver function tests including aminotransferase-to-platelet ratio index in monitoring liver dysfunction in short-gut infants of varying ages and intestinal lengths
    MICHAEL O'CONNOR
    Transplant Division, Department of Surgery, Indiana University, School of Medicine, Indianapolis, IN 46202, USA
    J Pediatr Surg 46:1057-63. 2011
  8. doi request reprint Double knockout pigs deficient in N-glycolylneuraminic acid and galactose α-1,3-galactose reduce the humoral barrier to xenotransplantation
    Andrew J Lutz
    Department of Surgery, IU Health Transplant Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Xenotransplantation 20:27-35. 2013
  9. doi request reprint No difference in clinical transplant outcomes for local and imported liver allografts
    Richard S Mangus
    Clarian Transplant Institute, Indiana University School of Medicine, Indianapolis, IN 46202 5250, USA
    Liver Transpl 15:640-7. 2009
  10. doi request reprint Primary porcine Kupffer cell phagocytosis of human platelets involves the CD18 receptor
    Ray K Chihara
    Department of Surgery, Indiana University Transplant Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Transplantation 92:739-44. 2011

Collaborators

Detail Information

Publications41

  1. ncbi request reprint Aberrations in hemostasis and coagulation in untreated discordant hepatic xenotransplantation: studies in the dog-to-pig model
    A Joseph Tector
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Liver Transpl 8:153-9. 2002
    ..In brief, the hemorrhage that accompanies liver xenotransplantation occurs because of a decrease in the number and function of circulating platelets in the recipient...
  2. ncbi request reprint Promising early results with immunosuppression using rabbit anti-thymocyte globulin and steroids with delayed introduction of tacrolimus in adult liver transplant recipients
    A Joseph Tector
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Liver Transpl 10:404-7. 2004
    ..RATG induction therapy is associated with good patient and graft survival, a low incidence of rejection, and minimal side effects. In addition, RATG induction is safe in patients transplanted for HCV...
  3. pmc Use of extended criteria livers decreases wait time for liver transplantation without adversely impacting posttransplant survival
    A Joseph Tector
    Department of Surgery, Transplantation Section, Gastroenterology Division, Indiana University School of Medicine, Indianapolis, IN 46202 5250, USA
    Ann Surg 244:439-50. 2006
    ..This study compares the graft/patient survival from standard (SD) and ECD for our transplant population between 2001 and 2005...
  4. ncbi request reprint Crossmatch-positive liver transplantation in patients receiving thymoglobulin-rituximab induction
    Chandrashekhar A Kubal
    1 Transplant Division, Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 2 Department of Pathology, Indiana University School of Medicine, Indianapolis, IN 3 Transplant Immunology Laboratory, Methodist Hospital, Indiana University School of Medicine, Indianapolis, IN 4 Transplant Division, Department of Surgery, University of Virginia, Charlottesville, VA 5 Address correspondence to Chandrashekhar A Kubal, M D, Ph D, Transplant Division, Department of Surgery, Indiana University School of Medicine, 550 North University Boulevard, Room 4601, Indianapolis, IN
    Transplantation 97:56-63. 2014
    ..Positive crossmatch (CM) in liver transplantation (LT) is associated with worse outcomes. Role of induction immunosuppression in this setting remains to be studied...
  5. doi request reprint Immortalized porcine liver sinusoidal endothelial cells: an in vitro model of xenotransplantation-induced thrombocytopenia
    Zheng Yu Wang
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
    Xenotransplantation 19:249-55. 2012
    ..Porcine iLSEC would enable continued study of xenotransplantation-induced thrombocytopenia in vitro with fewer animals sacrificed...
  6. doi request reprint Differences in human and porcine platelet oligosaccharides may influence phagocytosis by liver sinusoidal cells in vitro
    Leela L Paris
    Xenoimmunology Laboratory, Department of Surgery, Transplant Institute, Indiana University School of Medicine, Indiana University Health, Indianapolis, IN 46202, USA
    Xenotransplantation 19:31-9. 2012
    ..Analysis of these receptor carbohydrate-binding domains and surface carbohydrates on human and porcine platelets may shed light on the mechanism of xenotransplantation-induced thrombocytopenia...
  7. doi request reprint Utility of liver function tests including aminotransferase-to-platelet ratio index in monitoring liver dysfunction in short-gut infants of varying ages and intestinal lengths
    MICHAEL O'CONNOR
    Transplant Division, Department of Surgery, Indiana University, School of Medicine, Indianapolis, IN 46202, USA
    J Pediatr Surg 46:1057-63. 2011
    ..This study applies laboratory liver function testing, including APRI, to monitor liver dysfunction over time for short-gut infants, with further analysis of at-risk subpopulations...
  8. doi request reprint Double knockout pigs deficient in N-glycolylneuraminic acid and galactose α-1,3-galactose reduce the humoral barrier to xenotransplantation
    Andrew J Lutz
    Department of Surgery, IU Health Transplant Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Xenotransplantation 20:27-35. 2013
    ..Clinical xenotransplantation is not possible because humans possess antibodies that recognize antigens on the surface of pig cells. Galα-1,3-Gal (Gal) and N-glycolylneuraminic acid (Neu5Gc) are two known xenoantigens...
  9. doi request reprint No difference in clinical transplant outcomes for local and imported liver allografts
    Richard S Mangus
    Clarian Transplant Institute, Indiana University School of Medicine, Indianapolis, IN 46202 5250, USA
    Liver Transpl 15:640-7. 2009
    ..In conclusion, liver allografts rejected for use by a large number of transplant centers can still be successfully used without early graft function or long-term survival being affected...
  10. doi request reprint Primary porcine Kupffer cell phagocytosis of human platelets involves the CD18 receptor
    Ray K Chihara
    Department of Surgery, Indiana University Transplant Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Transplantation 92:739-44. 2011
    ..We sought to identify the role of KC CD18 in liver xenograft-induced thrombocytopenia...
  11. doi request reprint Fibronectin from alpha 1,3-galactosyltransferase knockout pigs is a xenoantigen
    Ray K Chihara
    Indiana University School of Medicine, Indianapolis, Indiana
    J Surg Res 184:1123-33. 2013
    ..N-glycolylneuraminic acid (Neu5Gc), similar to galactose α1,3-galactose, is an antigenic carbohydrate found in pigs. We evaluated human antibody reactivity and performed initial antigenic epitope characterization of Fn from GTKO pigs...
  12. doi request reprint Impact of positive flow cytometry crossmatch on outcomes of intestinal/multivisceral transplantation: role anti-IL-2 receptor antibody
    Chandrashekhar A Kubal
    Transplant Division, Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202 5250, USA
    Transplantation 95:1160-6. 2013
    ..This study reports the impact of positive flow cytometry crossmatch on clinical outcomes after intestinal/MV transplantation and the use of anti-interleukin (IL)-2 receptor antibody as a maintenance immunosuppressant...
  13. ncbi request reprint ASGR1 expressed by porcine enriched liver sinusoidal endothelial cells mediates human platelet phagocytosis in vitro
    Leela L Paris
    Department of Surgery, Indiana University School of Medicine, IU Health Transplant Institute, Indianapolis, IN 46202, USA
    Xenotransplantation 18:245-51. 2011
    ..Recently, it was discovered that porcine liver sinusoidal endothelial cells (LSEC) bind and phagocytose human platelets. We examined the role of ASGR1 in binding and removing human platelets by the pig liver endothelium...
  14. doi request reprint Use of the aspartate aminotransferase to platelet ratio index to follow liver fibrosis progression in infants with short gut
    Richard S Mangus
    Department of Surgery, Transplant Section, Indiana University School of Medicine, Indianapolis, IN 46202 5250, USA
    J Pediatr Surg 45:1266-73. 2010
    ..This study applies APRI scoring to parenteral nutrition-dependant, short-gut infants to determine hepatic fibrosis progression...
  15. doi request reprint Efficient selection of Gal-knockout pig cells for somatic cell nuclear transfer
    Luz M Reyes
    Department of Surgery, Transplant Surgery Section, Indiana University School of Medicine, Indianapolis, Indiana
    J Surg Res 184:e37-42. 2013
    ..The objective of this work was to generate a highly efficient system to select Gal-DKO cells to be used in SCNT without affecting the efficiency in production of Gal-null pigs...
  16. doi request reprint Immunosuppression induction with rabbit anti-thymocyte globulin with or without rituximab in 1000 liver transplant patients with long-term follow-up
    Richard S Mangus
    Transplant Division, Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202 5250, USA
    Liver Transpl 18:786-95. 2012
    ..05), and DCD (HR = 1.55, P = 0.11). rATG-based induction immunosuppression can be safely used in adult LT recipients with excellent survival and low rejection rates and without increases in immunosuppression-related side effects...
  17. doi request reprint Severe hypernatremia in deceased liver donors does not impact early transplant outcome
    Richard S Mangus
    Department of Surgery, Transplantation Section, Indiana University School of Medicine, Indianapolis, IN, USA
    Transplantation 90:438-43. 2010
    ..The purported mechanism for this effect is undefined. This study analyzes early graft function for donor livers procured from patients with severe hypernatremia...
  18. ncbi request reprint Induction immunosuppression with rabbit antithymocyte globulin in pediatric liver transplantation
    Ashesh Shah
    Surgery, Indiana University, Indianapolis, IN, USA
    Liver Transpl 12:1210-4. 2006
    ..In conclusion, our data suggest that RATG induction with steroid and tacrolimus maintenance therapy is safe, easy to use, and effective in the prevention of rejection...
  19. pmc De novo malignancy post-liver transplantation: a single center, population controlled study
    Hemant Chatrath
    Internal Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Clin Transplant 27:582-90. 2013
    ..With the growing numbers of liver transplant recipients, it is increasingly important to understand the risks of de novo malignancy after liver transplantation...
  20. doi request reprint Multivisceral transplantation: expanding indications and improving outcomes
    Richard S Mangus
    Transplant Division, Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
    J Gastrointest Surg 17:179-86; discussion p.186-7. 2013
    ..This study reviews the changing indications and outcomes for this procedure over a 7-year period at a university medical center...
  21. doi request reprint Outcomes of pancreas allografts procured simultaneously with an isolated intestine allograft: single-center and national data
    Jonathan A Fridell
    Department of Surgery, Indiana University School of Medicine, 550 N University Blvd 4258, Indianapolis, IN 46202, USA
    Transplantation 94:84-8. 2012
    ..This study reports the transplant outcomes for pancreas allografts procured simultaneously with an intestine graft...
  22. ncbi request reprint Steroid withdrawal for pancreas after kidney transplantation in recipients on maintenance prednisone immunosuppression
    Jonathan A Fridell
    Department of Surgery, Indiana University School of Medicine, Indianapolis, 46202, USA
    Transplantation 82:389-92. 2006
    ....
  23. ncbi request reprint Current status of small bowel and multivisceral transplantation
    Rodrigo M Vianna
    Intestinal and Multivisceral Transplantation, Transplant Surgery Section, Indiana University School of Medicine, Indiana University Hospital 4601, 550 N University Blvd, Indianapolis, IN 46202, USA
    Adv Surg 42:129-50. 2008
    ..Early referral for isolated intestinal transplant will reduce the need for simultaneous multiorgan transplants and increase the residual organs available for patients in need of (primarily) liver transplantation...
  24. doi request reprint Safe inclusion of the entire pancreas as a component of the multivisceral graft
    Rodrigo Vianna
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Transplantation 86:114-6. 2008
    ..We reviewed our experience with multivisceral grafts that included the entire pancreas...
  25. ncbi request reprint Comparison of histidine-tryptophan-ketoglutarate solution (HTK) and University of Wisconsin solution (UW) in adult liver transplantation
    Richard S Mangus
    Department of Surgery, Transplantation Section, Indiana University School of Medicine, Indianapolis, IN 46202 5250, USA
    Liver Transpl 12:226-30. 2006
    ..There were no significant differences between HTK and UW in this population when comparing 1 month graft function and first-year graft and patient survival...
  26. doi request reprint Comparison of histidine-tryptophan-ketoglutarate solution and University of Wisconsin solution in extended criteria liver donors
    Richard S Mangus
    Department of Surgery, Transplantation Section, Indiana University School of Medicine, Indianapolis, IN 46202 5250, USA
    Liver Transpl 14:365-73. 2008
    ..These findings persisted for both SCD and ECD livers. Given the lower cost per donor for HTK, this preservation solution may be preferable for general use...
  27. doi request reprint Mild to moderate pulmonary hypertension in liver transplantation
    Richard S Mangus
    Transplant Division, Department of Surgery, Indiana University, School of Medicine, Indianapolis, Indiana Electronic address
    J Surg Res 184:1150-6. 2013
    ..Patients with pulmonary hypertension (PHTN) are at increased risk for worse outcomes post-liver transplant (LT). This study evaluated LT outcomes and complications for a large number of LT patients with mild to moderate PHTN...
  28. doi request reprint Biallelic knockout of the α-1,3 galactosyltransferase gene in porcine liver-derived cells using zinc finger nucleases
    Ping Li
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Surg Res 181:e39-45. 2013
    ..ZFN-treated LDC were used as nuclear donors to produce fetuses and piglets via SCNT. All cloned fetuses and piglets showed biallelic knockout of GGTA1 gene...
  29. doi request reprint Identification of human preformed antibody targets in GTKO pigs
    Christopher Burlak
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Xenotransplantation 19:92-101. 2012
    ..This study examined the potential reactivity of human preformed IgG and IgM antibodies toward antigens in the GTKO pig liver...
  30. doi request reprint Multivisceral transplantation for diffuse portomesenteric thrombosis
    Rodrigo M Vianna
    Department of Surgery, Division of Transplantation, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Ann Surg 255:1144-50. 2012
    ..To evaluate the clinical outcomes of multivisceral transplantation (MVT) in the setting of diffuse thrombosis of the portomesenteric venous system...
  31. doi request reprint Evaluation of response after stereotactic body radiotherapy for hepatocellular carcinoma
    Tracy R Price
    Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Cancer 118:3191-8. 2012
    ..Stereotactic body radiotherapy (SBRT) is a noninvasive, effective therapy in the management of liver malignancies. The authors evaluated radiological response in 26 patients with HCC treated with SBRT at Indiana University...
  32. doi request reprint Stereotactic body radiotherapy for primary hepatocellular carcinoma
    David L Andolino
    Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Int J Radiat Oncol Biol Phys 81:e447-53. 2011
    ..To evaluate the safety and efficacy of stereotactic body radiotherapy (SBRT) for the treatment of primary hepatocellular carcinoma (HCC)...
  33. ncbi request reprint Intravenous interferon during the anhepatic phase of liver retransplantation and prevention of recurrence of cholestatic hepatitis C virus
    Paul Y Kwo
    Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202 5121, USA
    Liver Transpl 13:1710-3. 2007
    ..The role of anhepatic administration of interferon deserves further examination, and this combination may provide a solution in a subset of patients with an otherwise poor prognosis...
  34. doi request reprint Post-transplant critical care outcomes for pediatric multivisceral and intestinal transplant patients
    Courtney M Rowan
    Department of Pediatric Pulmonary, Critical Care and Allergy, Riley Hospital for Children, Indiana University Health, Indianapolis, IN 46202 5225, USA
    Pediatr Transplant 16:788-95. 2012
    ....
  35. doi request reprint Gene targeting and cloning in pigs using fetal liver derived cells
    Sanjeev K Waghmare
    Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Surg Res 171:e223-9. 2011
    ..The goal of this study was to test the feasibility of using fetal liver-derived cells (FLDC) to perform gene targeting, and create a genetic knockout pig...
  36. doi request reprint The fate of human platelets perfused through the pig liver: implications for xenotransplantation
    Christopher Burlak
    Department of Surgery, Clarian Transplant Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Xenotransplantation 17:350-61. 2010
    ..Studies in pig and baboon liver xenografts revealed the main obstacle to be a lethal thrombocytopenia that occurred within minutes to hours of transplantation...
  37. ncbi request reprint Epidemiology of acute liver failure
    Mouen Khashab
    Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, 675 West Walnut, IB 327, Indianapolis, IN 46202, USA
    Curr Gastroenterol Rep 9:66-73. 2007
    ..Liver support systems show potential for the treatment of ALF, but their role needs validation in large multicenter randomized trials...
  38. ncbi request reprint Portal versus systemic drainage of small bowel allografts: comparative assessment of survival, function, rejection, and bacterial translocation
    Thierry Berney
    Liver Gastrointestinal Transplantation, Department of Surgery, University of Miami School of Medicine, Miami, FL 33136, USA
    J Am Coll Surg 195:804-13. 2002
    ..Comparisons in animal models have not demonstrated a clear advantage of one technique over the other, but clinical data are lacking...
  39. pmc Clinical lung xenotransplantation--what donor genetic modifications may be necessary?
    David K C Cooper
    Thomas E Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Xenotransplantation 19:144-58. 2012
    ..The optimistic view would be that if experimental pig lung xenotransplantation could be successfully managed, it is likely that clinical application of this and all other forms of xenotransplantation would become more feasible...
  40. doi request reprint Laparoscopic incisional hernia repair after solid-organ transplantation
    Peter T Kennealey
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Arch Surg 144:228-33; discussion 233. 2009
    ..Laparoscopic incisional hernia repair (LIHR) is efficacious in transplant recipients...
  41. ncbi request reprint Hepatic sinusoidal endothelium upregulates IL-1alpha, IFN-gamma, and iNOS in response to discordant xenogeneic islets in an in vitro model of xenoislet transplantation
    Michael Tan
    Department of Surgery, McGill University Health Centre, Montreal, Canada
    J Surg Res 102:229-36. 2002
    ..We have characterized the initial response of hepatic endothelium to xenogeneic islets by measuring the expression of Il-1alpha, TNF-alpha, IFN-gamma, and iNOS in an in vitro dog-to-pig model of xenoislet transplantation...