TIMOTHY ALAN SUTTON

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. ncbi request reprint Endothelial injury and dysfunction: role in the extension phase of acute renal failure
    Bruce A Molitoris
    Division of Nephrology, Department of Medicine, and the Indiana Center for Biological Microscopy, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Kidney Int 66:496-9. 2004
  2. ncbi request reprint Rho-kinase regulates myosin II activation in MDCK cells during recovery after ATP depletion
    T A Sutton
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Am J Physiol Renal Physiol 281:F810-8. 2001
  3. pmc Fueling the fire in acute kidney injury: endothelial cells collect their Toll
    Timothy A Sutton
    Division of Nephrology, Department of Medicine and the Indiana Center for Biological Microscopy, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Kidney Int 79:267-9. 2011
  4. pmc Alteration of microvascular permeability in acute kidney injury
    Timothy A Sutton
    Division of Nephrology, Department of Medicine, Indiana Center for Biological Microscopy, Indiana University School of Medicine, 950 West Walnut Street R II, 202 Indianapolis, IN 46202, USA
    Microvasc Res 77:4-7. 2009
  5. pmc p53 regulates renal expression of HIF-1{alpha} and pVHL under physiological conditions and after ischemia-reperfusion injury
    Timothy A Sutton
    Div of Nephrology, Dept of Medicine, Indiana Univ School of Medicine, 950 West Walnut St, R II, 202, Indianapolis, IN 46202, USA
    Am J Physiol Renal Physiol 295:F1666-77. 2008
  6. pmc The p53 inhibitor pifithrin-α can stimulate fibrosis in a rat model of ischemic acute kidney injury
    Pierre C Dagher
    Div of Nephrology Dept of Medicine, Indiana Univ School of Medicine, Indianapolis, IN 46202, USA
    Am J Physiol Renal Physiol 302:F284-91. 2012
  7. ncbi request reprint Imaging vascular pathology
    Timothy A Sutton
    Division of Nephrology, Department of Medicine, Center for Biological Microscopy, Indiana University School of Medicine, Indianapolis, IN, USA
    Nephron Physiol 103:p82-5. 2006
  8. ncbi request reprint Minocycline reduces renal microvascular leakage in a rat model of ischemic renal injury
    Timothy A Sutton
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, 950 W Walnut, RII 202, Indianapolis, IN 46202, USA
    Am J Physiol Renal Physiol 288:F91-7. 2005
  9. ncbi request reprint Microvascular endothelial injury and dysfunction during ischemic acute renal failure
    Timothy A Sutton
    Division of Nephrology, Department of Medicine, and the Indiana Center for Biological Microscopy, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Kidney Int 62:1539-49. 2002
  10. ncbi request reprint Injury of the renal microvascular endothelium alters barrier function after ischemia
    Timothy A Sutton
    Division of Nephrology, Department of Medicine, Indiana Center for Biological Microscopy, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Am J Physiol Renal Physiol 285:F191-8. 2003

Research Grants

  1. Role of Myosin II in Ischemic Acute Renal Failure
    Timothy Sutton; Fiscal Year: 2006
  2. Mechanisms of microvascular damage in acute kidney injury
    TIMOTHY ALAN SUTTON; Fiscal Year: 2010
  3. Mechanisms of microvascular damage in acute kidney injury
    TIMOTHY ALAN SUTTON; Fiscal Year: 2010

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Endothelial injury and dysfunction: role in the extension phase of acute renal failure
    Bruce A Molitoris
    Division of Nephrology, Department of Medicine, and the Indiana Center for Biological Microscopy, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Kidney Int 66:496-9. 2004
    ..New diagnostic and therapeutic approaches to ischemic ARF must incorporate these finding to devise early recognition strategies and therapeutic approaches...
  2. ncbi request reprint Rho-kinase regulates myosin II activation in MDCK cells during recovery after ATP depletion
    T A Sutton
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Am J Physiol Renal Physiol 281:F810-8. 2001
    ..Furthermore, myosin activation and actin stress fiber formation were found to be Rho-associated Ser/Thr protein kinase dependent during recovery from ATP depletion...
  3. pmc Fueling the fire in acute kidney injury: endothelial cells collect their Toll
    Timothy A Sutton
    Division of Nephrology, Department of Medicine and the Indiana Center for Biological Microscopy, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Kidney Int 79:267-9. 2011
    ..This activation can serve to amplify inflammation and tubular damage...
  4. pmc Alteration of microvascular permeability in acute kidney injury
    Timothy A Sutton
    Division of Nephrology, Department of Medicine, Indiana Center for Biological Microscopy, Indiana University School of Medicine, 950 West Walnut Street R II, 202 Indianapolis, IN 46202, USA
    Microvasc Res 77:4-7. 2009
    ..This review examines alterations of the renal microvasculature as they relate to ischemic and septic AKI with an emphasis on the mechanisms involved in altered microvascular permeability...
  5. pmc p53 regulates renal expression of HIF-1{alpha} and pVHL under physiological conditions and after ischemia-reperfusion injury
    Timothy A Sutton
    Div of Nephrology, Dept of Medicine, Indiana Univ School of Medicine, 950 West Walnut St, R II, 202, Indianapolis, IN 46202, USA
    Am J Physiol Renal Physiol 295:F1666-77. 2008
    ..We conclude that activation of p53 after IRI mitigates the concomitant activation of the protective HIF-1 pathway. Modulating the interactions between the p53 and HIF-1 pathway can provide novel options in the treatment of AKI...
  6. pmc The p53 inhibitor pifithrin-α can stimulate fibrosis in a rat model of ischemic acute kidney injury
    Pierre C Dagher
    Div of Nephrology Dept of Medicine, Indiana Univ School of Medicine, Indianapolis, IN 46202, USA
    Am J Physiol Renal Physiol 302:F284-91. 2012
    ..We identified enhanced extracellular matrix production, epithelial-to-mesenchymal transition, and amplified inflammatory responses as potential contributors to the augmented fibrosis observed with PA administration of pifithrin-α...
  7. ncbi request reprint Imaging vascular pathology
    Timothy A Sutton
    Division of Nephrology, Department of Medicine, Center for Biological Microscopy, Indiana University School of Medicine, Indianapolis, IN, USA
    Nephron Physiol 103:p82-5. 2006
    ....
  8. ncbi request reprint Minocycline reduces renal microvascular leakage in a rat model of ischemic renal injury
    Timothy A Sutton
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, 950 W Walnut, RII 202, Indianapolis, IN 46202, USA
    Am J Physiol Renal Physiol 288:F91-7. 2005
    ..This effect is spatially distinct from the effect of minocycline on leukocyte accumulation and may be related to diminished activity of MMPs on the integrity of the perivascular matrix...
  9. ncbi request reprint Microvascular endothelial injury and dysfunction during ischemic acute renal failure
    Timothy A Sutton
    Division of Nephrology, Department of Medicine, and the Indiana Center for Biological Microscopy, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Kidney Int 62:1539-49. 2002
    ..This knowledge should provide new diagnostic and therapeutic approaches to ischemic ARF...
  10. ncbi request reprint Injury of the renal microvascular endothelium alters barrier function after ischemia
    Timothy A Sutton
    Division of Nephrology, Department of Medicine, Indiana Center for Biological Microscopy, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Am J Physiol Renal Physiol 285:F191-8. 2003
    ..Taken together, these findings indicate that renal vascular endothelial injury occurs in ischemic ARF and may play an important role in the pathophysiology of ischemic ARF...
  11. ncbi request reprint Acute and chronic microvascular alterations in a mouse model of ischemic acute kidney injury
    Markus Horbelt
    Division of Nephrology, Department of Medicine and the Indiana Center for Biological Microscopy, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Am J Physiol Renal Physiol 293:F688-95. 2007
    ....
  12. ncbi request reprint Functional studies in living animals using multiphoton microscopy
    KENNETH WILLIAM DUNN
    Department of Medicine, Division of Nephrology, Indiana University Medical Center, Indianapolis, IN 46202 5116, USA
    ILAR J 49:66-77. 2008
    ..We also review specific examples of the application of in vivo multiphoton microscopy to studies of physiology and pathology in a variety of organs including the brain, skin, skeletal muscle, tumors, immune cells, and visceral organs...
  13. pmc Preservation of peritubular capillary endothelial integrity and increasing pericytes may be critical to recovery from postischemic acute kidney injury
    Osun Kwon
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Am J Physiol Renal Physiol 295:F351-9. 2008
    ..Preservation of peritubular capillary endothelial integrity and increasing pericytes may be critical to recovery from postischemic AKI...
  14. pmc Impaired endothelial proliferation and mesenchymal transition contribute to vascular rarefaction following acute kidney injury
    David P Basile
    Department of Cellular and Integrative Physiology, Indiana Center for Biological Microscopy, Indiana University, Indianapolis, Indiana
    Am J Physiol Renal Physiol 300:F721-33. 2011
    ..Taken together, these data indicate that vascular dropout post-AKI results from endothelial phenotypic transition combined with an impaired regenerative capacity, which may contribute to progressive chronic kidney disease...
  15. ncbi request reprint Endothelial injury and dysfunction in ischemic acute renal failure
    Bruce A Molitoris
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Crit Care Med 30:S235-40. 2002
    ..Intravital studies using multiphoton imaging techniques can now be conducted to identify and quantify endothelial cell injury and dysfunction in functioning organs...
  16. ncbi request reprint Live-animal imaging of renal function by multiphoton microscopy
    Kenneth W Dunn
    Indiana University School of Medicine, Indianapolis, Indiana, USA
    Curr Protoc Cytom . 2007
    ....
  17. pmc MMP-9 gene deletion mitigates microvascular loss in a model of ischemic acute kidney injury
    So Young Lee
    Div of Nephrology Dept of Medicine, Indiana University School of Medicine, 950 West Walnut St, R 2, 202, Indianapolis, IN 46202, USA
    Am J Physiol Renal Physiol 301:F101-9. 2011
    ..In conclusion, MMP-9 deletion stabilizes microvascular density following ischemic AKI in part by preserving tissue VEGF levels...

Research Grants7

  1. Role of Myosin II in Ischemic Acute Renal Failure
    Timothy Sutton; Fiscal Year: 2006
    ..Mutant forms of MLCK and ROCK proteins will be co-expressed in MDCK cells to alter cellular signaling. ..
  2. Mechanisms of microvascular damage in acute kidney injury
    TIMOTHY ALAN SUTTON; Fiscal Year: 2010
    ....
  3. Mechanisms of microvascular damage in acute kidney injury
    TIMOTHY ALAN SUTTON; Fiscal Year: 2010
    ....