Research Topics
Genomes and GenesSpecies | William J SullivanSummaryAffiliation: Indiana University Country: USA Publications
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Publications
Mechanisms of Toxoplasma gondii persistence and latencyWilliam J Sullivan
Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
FEMS Microbiol Rev 36:717-33. 2012....
Molecular cloning and characterization of an SRCAP chromatin remodeling homologue in Toxoplasma gondiiWilliam J Sullivan
Department of Pharmacology and Toxicology, Room A 527, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202 5120, USA
Parasitol Res 90:1-8. 2003..Recombinant TgSRCAP protein is functionally equivalent to the human homologue, being capable of increasing transcription mediated by CREB...- Histone H3 and H3.3 variants in the protozoan pathogens Plasmodium falciparum and Toxoplasma gondiiWilliam J Sullivan
Department of Pharmacology and Toxicology, Medical Sciences Building Room A517, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202 5120, USA
DNA Seq 14:227-31. 2003..Expression and purification of recombinant H3 variants will provide species-specific substrate for the analysis of the histone-modifying machinery of these parasites... - Parasite-specific eIF2 (eukaryotic initiation factor-2) kinase required for stress-induced translation controlWilliam J Sullivan
Department of Pharmacology and Toxicology, Indiana University School of Medicine, 635 Barnhill Drive, Medical Sciences Bldg, Indianapolis, IN 46202, USA
Biochem J 380:523-31. 2004.... - Understanding mechanisms and the role of differentiation in pathogenesis of Toxoplasma gondii: a reviewWilliam J Sullivan Jr
Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Mem Inst Oswaldo Cruz 104:155-61. 2009..In addition to a summary of the current state of knowledge in these areas we discuss the pharmacological ramifications and pose some questions for future research... - Histones and histone modifications in protozoan parasitesWilliam J Sullivan
Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana, USA
Cell Microbiol 8:1850-61. 2006..As we describe in this review, such studies provide a unique vantage point of the evolutionary picture of eukaryotic cell development, and reveal unique phenomena that could be exploited pharmacologically to treat protozoal diseases... - Histone mediated gene activation in Toxoplasma gondiiWilliam J Sullivan
Department of Pharmacology and Toxicology, Indiana University School of Medicine, 635 Barnhill Drive, MS A 525, Indianapolis, IN 46202, USA
Mol Biochem Parasitol 148:109-16. 2006..Here we present a synthesis of the current knowledge of histone mediated gene expression in Toxoplasma, particularly in the context of parasite differentiation... - Translation regulation by eukaryotic initiation factor-2 kinases in the development of latent cysts in Toxoplasma gondiiJana Narasimhan
Department of Pharmacology and Toxicology and Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
J Biol Chem 283:16591-601. 2008..Given its importance to pathogenesis, eIF2 kinase-mediated stress responses may provide opportunities for novel therapeutics... - MYST family lysine acetyltransferase facilitates ataxia telangiectasia mutated (ATM) kinase-mediated DNA damage response in Toxoplasma gondiiNathalie Vonlaufen
Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
J Biol Chem 285:11154-61. 2010..These studies are the first to show that a MYST KAT contributes to ATM kinase gene expression, further illuminating the mechanism of how ATM kinase is up-regulated to respond to DNA damage... - Lysine acetylation is widespread on proteins of diverse function and localization in the protozoan parasite Toxoplasma gondiiVictoria Jeffers
Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana, USA
Eukaryot Cell 11:735-42. 2012.... - Phosphorylation of eukaryotic initiation factor-2{alpha} promotes the extracellular survival of obligate intracellular parasite Toxoplasma gondiiBradley R Joyce
Departments of Pharmacology and Toxicology and Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Proc Natl Acad Sci U S A 107:17200-5. 2010..We conclude that the phosphorylation of TgIF2α plays a crucial role during the lytic cycle by ameliorating the stress of the extracellular environment while the parasite searches for a new host cell... - A decade of epigenetic research in Toxoplasma gondiiStacy E Dixon
Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, 46202, United States
Mol Biochem Parasitol 173:1-9. 2010..We will close by proposing a few questions to address in the next 10 years... - MYST family histone acetyltransferases in the protozoan parasite Toxoplasma gondiiAaron T Smith
Department of Pharmacology and Toxicology, Indiana University School of Medicine, 635 Barnhill Drive, Medical Sciences Building Room A-525, Indianapolis, IN 46202-5120, USA
Eukaryot Cell 4:2057-65. 2005.... - Base excision repair apurinic/apyrimidinic endonucleases in apicomplexan parasite Toxoplasma gondiiDavid O Onyango
Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, 46202, United States
DNA Repair (Amst) 10:466-75. 2011..The importance of TgAPN and the fact that humans lack any observable APN family activity highlights TgAPN as a promising candidate for drug development to treat toxoplasmosis... - Pair of unusual GCN5 histone acetyltransferases and ADA2 homologues in the protozoan parasite Toxoplasma gondiiMicah M Bhatti
Department of Pharmacology and Toxicology, Indiana University School of Medicine, 635 Barnhill Drive, Medical Sciences Building, Room A-525, Indianapolis, Indiana 46202-5120, USA
Eukaryot Cell 5:62-76. 2006..TgGCN5-B has the potential to compensate for TgGCN5-A, which probably arose from a gene duplication unique to T. gondii. Our work reveals an unexpected complexity in the GCN5 machinery of this primitive eukaryote... - Identification of proteins interacting with Toxoplasma SRCAP by yeast two-hybrid screeningKaruna C Nallani
Department of Pharmacology and Toxicology, Indiana University School of Medicine, Medical Sciences Building Room A-525, 635 Barnhill Drive, Indianapolis, IN 46202, USA
Parasitol Res 95:236-42. 2005..We have identified several novel parasite-specific transcription factors predicted to be in the T. gondii genome. Metabolic enzymes that may participate in cyst development were also identified as interacting with TgSRCAP... - IMP dehydrogenase from the protozoan parasite Toxoplasma gondiiWilliam J Sullivan
Department of Pharmacology and Toxicology, Medical Sciences Building Room A-519, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202-5120, USA
Antimicrob Agents Chemother 49:2172-9. 2005.... - Toxoplasma gondii lysine acetyltransferase GCN5-A functions in the cellular response to alkaline stress and expression of cyst genesArunasalam Naguleswaran
Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana, USA
PLoS Pathog 6:e1001232. 2010..These results establish TgGCN5-A as a major contributor to the alkaline stress response in RH strain Toxoplasma... - A GCN2-like eukaryotic initiation factor 2 kinase increases the viability of extracellular Toxoplasma gondii parasitesChristian Konrad
Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Eukaryot Cell 10:1403-12. 2011..Additionally, TgIF2α is phosphorylated when intracellular parasites are deprived of nutrients, but this can occur independently of TgIF2K-D, indicating that this activity can be mediated by a different TgIF2K... - Azurin-like protein blocks invasion of Toxoplasma gondii through potential interactions with parasite surface antigen SAG1Arunasalam Naguleswaran
Pharmacology and Toxicology, Center for AIDS Research, Indiana University School of Medicine, 635 Barnhill Drive, MS A 525, Indianapolis, IN 46202, USA
Antimicrob Agents Chemother 52:402-8. 2008..These observations indicate that Laz can serve as an important tool in the study of host-pathogen interactions and is worthy of further study for development into potential therapeutic agents... - Regions of intrinsic disorder help identify a novel nuclear localization signal in Toxoplasma gondii histone acetyltransferase TgGCN5-BStacy E Dixon
Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Mol Biochem Parasitol 175:192-5. 2011..These studies demonstrate that basic-rich sequences within regions predicted to be intrinsically disordered constitute criteria for a candidate NLS... 
Inhibitors of eIF2α dephosphorylation slow replication and stabilize latency in Toxoplasma gondiiChristian Konrad
Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA
Antimicrob Agents Chemother 57:1815-22. 2013..Our findings suggest that SAL and GA may serve as potential new drugs for the treatment of acute and chronic toxoplasmosis...- Histone acetylase GCN5 enters the nucleus via importin-alpha in protozoan parasite Toxoplasma gondiiMicah M Bhatti
Department of Pharmacology and Toxicology, Indiana University School of Medicine, 635 Barnhill Dr, Indianapolis, IN 46202, USA
J Biol Chem 280:5902-8. 2005..gondii genome reveals that other components of the importin pathway are present in the organism. This study demonstrates the utility of T. gondii as a model for the study of nucleocytoplasmic trafficking in early eukaryotic cells... - Quinoline derivative MC1626, a putative GCN5 histone acetyltransferase (HAT) inhibitor, exhibits HAT-independent activity against Toxoplasma gondiiAaron T Smith
Department of Pharmacology and Toxicology, IU Center For AIDS Research, Indiana University School of Medicine, 635 Barnhill Drive, MS A 525, Indianapolis, IN 46202, USA
Antimicrob Agents Chemother 51:1109-11. 2007..However, MC1626 does not inhibit Toxoplasma GCN5 HATs or reduce HAT-mediated activity; rather, this quinoline may target the plastid organelle called the apicoplast... - Stress response pathways in protozoan parasitesNathalie Vonlaufen
Departments of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN, USA
Cell Microbiol 10:2387-99. 2008..This review summarizes the research on parasitic stress responses for Apicomplexa, kinetoplastids and anaerobic protozoa, with an eye towards how these processes may be exploited therapeutically...
Research Grants
- GCN5-mediated transcription in AIDS pathogen ToxoplasmaWILLIAM SULLIVAN JR; Fiscal Year: 2009..The regulation of gene expression plays a key role in this pathogenic process; therefore, our results stand a high probability of translating into useful new therapies to combat opportunistic infectious diseases like Toxoplasma. ..
- APEs as novel drug targets in AIDS opportunistic pathogen ToxoplasmaWILLIAM SULLIVAN JR; Fiscal Year: 2007..Toxoplasma is also listed by NIAID as a category B pathogen relevant to Biodefense research. Moreover, Toxoplasma can be informative as a model organism to study Plasmodium, the causative agent of malaria. ..
- GCN5-mediated transcription in AIDS pathogen ToxoplasmaWILLIAM SULLIVAN JR; Fiscal Year: 2007..gondii. Collectively, these aims will answer how TgGCN5 and its assocated molecules regulate transcription, significantly contributing to our knowledge about the gene regulatory circuitry in this group of important pathogens. ..
- GCN5-mediated transcription in AIDS pathogen ToxoplasmaWilliam J Sullivan Jr; Fiscal Year: 2010..The regulation of gene expression plays a key role in this pathogenic process;therefore, our results stand a high probability of translating into useful new therapies to combat opportunistic infectious diseases like Toxoplasma. ..