William J Sullivan

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. pmc Toxoplasma gondii lysine acetyltransferase GCN5-A functions in the cellular response to alkaline stress and expression of cyst genes
    Arunasalam Naguleswaran
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    PLoS Pathog 6:e1001232. 2010
  2. pmc Mechanisms of Toxoplasma gondii persistence and latency
    William J Sullivan
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    FEMS Microbiol Rev 36:717-33. 2012
  3. ncbi request reprint Molecular cloning and characterization of an SRCAP chromatin remodeling homologue in Toxoplasma gondii
    William J Sullivan
    Department of Pharmacology and Toxicology, Room A 527, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202 5120, USA
    Parasitol Res 90:1-8. 2003
  4. pmc Understanding mechanisms and the role of differentiation in pathogenesis of Toxoplasma gondii: a review
    William J Sullivan Jr
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Mem Inst Oswaldo Cruz 104:155-61. 2009
  5. ncbi request reprint Histones and histone modifications in protozoan parasites
    William J Sullivan
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Cell Microbiol 8:1850-61. 2006
  6. ncbi request reprint Histone mediated gene activation in Toxoplasma gondii
    William J Sullivan
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, 635 Barnhill Drive, MS A 525, Indianapolis, IN 46202, USA
    Mol Biochem Parasitol 148:109-16. 2006
  7. ncbi request reprint Histone H3 and H3.3 variants in the protozoan pathogens Plasmodium falciparum and Toxoplasma gondii
    William J Sullivan
    Department of Pharmacology and Toxicology, Medical Sciences Building Room A517, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202 5120, USA
    DNA Seq 14:227-31. 2003
  8. pmc Parasite-specific eIF2 (eukaryotic initiation factor-2) kinase required for stress-induced translation control
    William J Sullivan
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, 635 Barnhill Drive, Medical Sciences Bldg, Indianapolis, IN 46202, USA
    Biochem J 380:523-31. 2004
  9. pmc Translation regulation by eukaryotic initiation factor-2 kinases in the development of latent cysts in Toxoplasma gondii
    Jana Narasimhan
    Department of Pharmacology and Toxicology and Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 283:16591-601. 2008
  10. pmc MYST family lysine acetyltransferase facilitates ataxia telangiectasia mutated (ATM) kinase-mediated DNA damage response in Toxoplasma gondii
    Nathalie Vonlaufen
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 285:11154-61. 2010

Research Grants

  1. GCN5-mediated transcription in AIDS pathogen Toxoplasma
    WILLIAM SULLIVAN JR; Fiscal Year: 2003
  2. GCN5-mediated transcription in AIDS pathogen Toxoplasma
    WILLIAM SULLIVAN JR; Fiscal Year: 2009
  3. APEs as novel drug targets in AIDS opportunistic pathogen Toxoplasma
    WILLIAM SULLIVAN JR; Fiscal Year: 2007
  4. GCN5-mediated transcription in AIDS pathogen Toxoplasma
    WILLIAM SULLIVAN JR; Fiscal Year: 2007
  5. GCN5-mediated transcription in AIDS pathogen Toxoplasma
    WILLIAM SULLIVAN JR; Fiscal Year: 2006
  6. GCN5-mediated transcription in AIDS pathogen Toxoplasma
    WILLIAM SULLIVAN JR; Fiscal Year: 2005
  7. GCN5-mediated transcription in AIDS pathogen Toxoplasma
    WILLIAM SULLIVAN JR; Fiscal Year: 2004
  8. GCN5-mediated transcription in AIDS pathogen Toxoplasma
    William J Sullivan Jr; Fiscal Year: 2010

Collaborators

Detail Information

Publications29

  1. pmc Toxoplasma gondii lysine acetyltransferase GCN5-A functions in the cellular response to alkaline stress and expression of cyst genes
    Arunasalam Naguleswaran
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    PLoS Pathog 6:e1001232. 2010
    ..These results establish TgGCN5-A as a major contributor to the alkaline stress response in RH strain Toxoplasma...
  2. pmc Mechanisms of Toxoplasma gondii persistence and latency
    William J Sullivan
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    FEMS Microbiol Rev 36:717-33. 2012
    ....
  3. ncbi request reprint Molecular cloning and characterization of an SRCAP chromatin remodeling homologue in Toxoplasma gondii
    William J Sullivan
    Department of Pharmacology and Toxicology, Room A 527, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202 5120, USA
    Parasitol Res 90:1-8. 2003
    ..Recombinant TgSRCAP protein is functionally equivalent to the human homologue, being capable of increasing transcription mediated by CREB...
  4. pmc Understanding mechanisms and the role of differentiation in pathogenesis of Toxoplasma gondii: a review
    William J Sullivan Jr
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Mem Inst Oswaldo Cruz 104:155-61. 2009
    ..In addition to a summary of the current state of knowledge in these areas we discuss the pharmacological ramifications and pose some questions for future research...
  5. ncbi request reprint Histones and histone modifications in protozoan parasites
    William J Sullivan
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Cell Microbiol 8:1850-61. 2006
    ..As we describe in this review, such studies provide a unique vantage point of the evolutionary picture of eukaryotic cell development, and reveal unique phenomena that could be exploited pharmacologically to treat protozoal diseases...
  6. ncbi request reprint Histone mediated gene activation in Toxoplasma gondii
    William J Sullivan
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, 635 Barnhill Drive, MS A 525, Indianapolis, IN 46202, USA
    Mol Biochem Parasitol 148:109-16. 2006
    ..Here we present a synthesis of the current knowledge of histone mediated gene expression in Toxoplasma, particularly in the context of parasite differentiation...
  7. ncbi request reprint Histone H3 and H3.3 variants in the protozoan pathogens Plasmodium falciparum and Toxoplasma gondii
    William J Sullivan
    Department of Pharmacology and Toxicology, Medical Sciences Building Room A517, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202 5120, USA
    DNA Seq 14:227-31. 2003
    ..Expression and purification of recombinant H3 variants will provide species-specific substrate for the analysis of the histone-modifying machinery of these parasites...
  8. pmc Parasite-specific eIF2 (eukaryotic initiation factor-2) kinase required for stress-induced translation control
    William J Sullivan
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, 635 Barnhill Drive, Medical Sciences Bldg, Indianapolis, IN 46202, USA
    Biochem J 380:523-31. 2004
    ....
  9. pmc Translation regulation by eukaryotic initiation factor-2 kinases in the development of latent cysts in Toxoplasma gondii
    Jana Narasimhan
    Department of Pharmacology and Toxicology and Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 283:16591-601. 2008
    ..Given its importance to pathogenesis, eIF2 kinase-mediated stress responses may provide opportunities for novel therapeutics...
  10. pmc MYST family lysine acetyltransferase facilitates ataxia telangiectasia mutated (ATM) kinase-mediated DNA damage response in Toxoplasma gondii
    Nathalie Vonlaufen
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 285:11154-61. 2010
    ..These studies are the first to show that a MYST KAT contributes to ATM kinase gene expression, further illuminating the mechanism of how ATM kinase is up-regulated to respond to DNA damage...
  11. pmc Lysine acetylation is widespread on proteins of diverse function and localization in the protozoan parasite Toxoplasma gondii
    Victoria Jeffers
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Eukaryot Cell 11:735-42. 2012
    ....
  12. pmc MYST family histone acetyltransferases in the protozoan parasite Toxoplasma gondii
    Aaron T Smith
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, 635 Barnhill Drive, Medical Sciences Building Room A 525, Indianapolis, IN 46202 5120, USA
    Eukaryot Cell 4:2057-65. 2005
    ....
  13. pmc The unfolded protein response in the protozoan parasite Toxoplasma gondii features translational and transcriptional control
    Bradley R Joyce
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Eukaryot Cell 12:979-89. 2013
    ..This study indicates that Toxoplasma triggers a UPR during ER stress that features both translational and transcriptional regulatory mechanisms, which is likely to be important for parasite invasion and development. ..
  14. pmc Phosphorylation of eukaryotic initiation factor-2{alpha} promotes the extracellular survival of obligate intracellular parasite Toxoplasma gondii
    Bradley R Joyce
    Departments of Pharmacology and Toxicology and Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Proc Natl Acad Sci U S A 107:17200-5. 2010
    ..We conclude that the phosphorylation of TgIF2α plays a crucial role during the lytic cycle by ameliorating the stress of the extracellular environment while the parasite searches for a new host cell...
  15. pmc A decade of epigenetic research in Toxoplasma gondii
    Stacy E Dixon
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, 46202, United States
    Mol Biochem Parasitol 173:1-9. 2010
    ..We will close by proposing a few questions to address in the next 10 years...
  16. pmc Pair of unusual GCN5 histone acetyltransferases and ADA2 homologues in the protozoan parasite Toxoplasma gondii
    Micah M Bhatti
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, 635 Barnhill Drive, Medical Sciences Building, Room A 525, Indianapolis, Indiana 46202 5120, USA
    Eukaryot Cell 5:62-76. 2006
    ..TgGCN5-B has the potential to compensate for TgGCN5-A, which probably arose from a gene duplication unique to T. gondii. Our work reveals an unexpected complexity in the GCN5 machinery of this primitive eukaryote...
  17. pmc Base excision repair apurinic/apyrimidinic endonucleases in apicomplexan parasite Toxoplasma gondii
    David O Onyango
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, 46202, United States
    DNA Repair (Amst) 10:466-75. 2011
    ..The importance of TgAPN and the fact that humans lack any observable APN family activity highlights TgAPN as a promising candidate for drug development to treat toxoplasmosis...
  18. pmc IMP dehydrogenase from the protozoan parasite Toxoplasma gondii
    William J Sullivan
    Department of Pharmacology and Toxicology, Medical Sciences Building Room A 519, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202 5120, USA
    Antimicrob Agents Chemother 49:2172-9. 2005
    ....
  19. pmc Inhibitors of eIF2α dephosphorylation slow replication and stabilize latency in Toxoplasma gondii
    Christian Konrad
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Antimicrob Agents Chemother 57:1815-22. 2013
    ..Our findings suggest that SAL and GA may serve as potential new drugs for the treatment of acute and chronic toxoplasmosis...
  20. ncbi request reprint Identification of proteins interacting with Toxoplasma SRCAP by yeast two-hybrid screening
    Karuna C Nallani
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, Medical Sciences Building Room A 525, 635 Barnhill Drive, Indianapolis, IN 46202, USA
    Parasitol Res 95:236-42. 2005
    ..We have identified several novel parasite-specific transcription factors predicted to be in the T. gondii genome. Metabolic enzymes that may participate in cyst development were also identified as interacting with TgSRCAP...
  21. pmc A GCN2-like eukaryotic initiation factor 2 kinase increases the viability of extracellular Toxoplasma gondii parasites
    Christian Konrad
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Eukaryot Cell 10:1403-12. 2011
    ..Additionally, TgIF2α is phosphorylated when intracellular parasites are deprived of nutrients, but this can occur independently of TgIF2K-D, indicating that this activity can be mediated by a different TgIF2K...
  22. pmc Azurin-like protein blocks invasion of Toxoplasma gondii through potential interactions with parasite surface antigen SAG1
    Arunasalam Naguleswaran
    Pharmacology and Toxicology, Center for AIDS Research, Indiana University School of Medicine, 635 Barnhill Drive, MS A 525, Indianapolis, IN 46202, USA
    Antimicrob Agents Chemother 52:402-8. 2008
    ..These observations indicate that Laz can serve as an important tool in the study of host-pathogen interactions and is worthy of further study for development into potential therapeutic agents...
  23. pmc Regions of intrinsic disorder help identify a novel nuclear localization signal in Toxoplasma gondii histone acetyltransferase TgGCN5-B
    Stacy E Dixon
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Mol Biochem Parasitol 175:192-5. 2011
    ..These studies demonstrate that basic-rich sequences within regions predicted to be intrinsically disordered constitute criteria for a candidate NLS...
  24. ncbi request reprint Histone acetylase GCN5 enters the nucleus via importin-alpha in protozoan parasite Toxoplasma gondii
    Micah M Bhatti
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, 635 Barnhill Dr, Indianapolis, IN 46202, USA
    J Biol Chem 280:5902-8. 2005
    ..gondii genome reveals that other components of the importin pathway are present in the organism. This study demonstrates the utility of T. gondii as a model for the study of nucleocytoplasmic trafficking in early eukaryotic cells...
  25. pmc Elongator protein 3 (Elp3) lysine acetyltransferase is a tail-anchored mitochondrial protein in Toxoplasma gondii
    Krista L Stilger
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 288:25318-29. 2013
    ..Importantly, we also present genetic studies that suggest TgElp3 is essential in Toxoplasma and must be positioned at the mitochondrial surface for parasite viability. ..
  26. pmc Lysine acetyltransferase GCN5b interacts with AP2 factors and is required for Toxoplasma gondii proliferation
    Jiachen Wang
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
    PLoS Pathog 10:e1003830. 2014
    ..We conclude that GCN5b has a non-redundant and indispensable role in regulating gene expression required during the Toxoplasma lytic cycle. ..
  27. pmc Quinoline derivative MC1626, a putative GCN5 histone acetyltransferase (HAT) inhibitor, exhibits HAT-independent activity against Toxoplasma gondii
    Aaron T Smith
    Department of Pharmacology and Toxicology, IU Center For AIDS Research, Indiana University School of Medicine, 635 Barnhill Drive, MS A 525, Indianapolis, IN 46202, USA
    Antimicrob Agents Chemother 51:1109-11. 2007
    ..However, MC1626 does not inhibit Toxoplasma GCN5 HATs or reduce HAT-mediated activity; rather, this quinoline may target the plastid organelle called the apicoplast...
  28. pmc GCN2-like eIF2α kinase manages the amino acid starvation response in Toxoplasma gondii
    Christian Konrad
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Int J Parasitol 44:139-46. 2014
    ..These studies suggest that Toxoplasma GCN2-like kinases TgIF2K-C and TgIF2K-D evolved to have distinct roles in adapting to changes in the parasite's environment. ..
  29. doi request reprint Stress response pathways in protozoan parasites
    Nathalie Vonlaufen
    Departments of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN, USA
    Cell Microbiol 10:2387-99. 2008
    ..This review summarizes the research on parasitic stress responses for Apicomplexa, kinetoplastids and anaerobic protozoa, with an eye towards how these processes may be exploited therapeutically...

Research Grants10

  1. GCN5-mediated transcription in AIDS pathogen Toxoplasma
    WILLIAM SULLIVAN JR; Fiscal Year: 2003
    ..gondii. Collectively, these aims will answer how TgGCN5 and its assocated molecules regulate transcription, significantly contributing to our knowledge about the gene regulatory circuitry in this group of important pathogens. ..
  2. GCN5-mediated transcription in AIDS pathogen Toxoplasma
    WILLIAM SULLIVAN JR; Fiscal Year: 2009
    ..The regulation of gene expression plays a key role in this pathogenic process; therefore, our results stand a high probability of translating into useful new therapies to combat opportunistic infectious diseases like Toxoplasma. ..
  3. APEs as novel drug targets in AIDS opportunistic pathogen Toxoplasma
    WILLIAM SULLIVAN JR; Fiscal Year: 2007
    ..Toxoplasma is also listed by NIAID as a category B pathogen relevant to Biodefense research. Moreover, Toxoplasma can be informative as a model organism to study Plasmodium, the causative agent of malaria. ..
  4. GCN5-mediated transcription in AIDS pathogen Toxoplasma
    WILLIAM SULLIVAN JR; Fiscal Year: 2007
    ..gondii. Collectively, these aims will answer how TgGCN5 and its assocated molecules regulate transcription, significantly contributing to our knowledge about the gene regulatory circuitry in this group of important pathogens. ..
  5. GCN5-mediated transcription in AIDS pathogen Toxoplasma
    WILLIAM SULLIVAN JR; Fiscal Year: 2006
    ..gondii. Collectively, these aims will answer how TgGCN5 and its assocated molecules regulate transcription, significantly contributing to our knowledge about the gene regulatory circuitry in this group of important pathogens. ..
  6. GCN5-mediated transcription in AIDS pathogen Toxoplasma
    WILLIAM SULLIVAN JR; Fiscal Year: 2005
    ..gondii. Collectively, these aims will answer how TgGCN5 and its assocated molecules regulate transcription, significantly contributing to our knowledge about the gene regulatory circuitry in this group of important pathogens. ..
  7. GCN5-mediated transcription in AIDS pathogen Toxoplasma
    WILLIAM SULLIVAN JR; Fiscal Year: 2004
    ..gondii. Collectively, these aims will answer how TgGCN5 and its assocated molecules regulate transcription, significantly contributing to our knowledge about the gene regulatory circuitry in this group of important pathogens. ..
  8. GCN5-mediated transcription in AIDS pathogen Toxoplasma
    William J Sullivan Jr; Fiscal Year: 2010
    ..The regulation of gene expression plays a key role in this pathogenic process;therefore, our results stand a high probability of translating into useful new therapies to combat opportunistic infectious diseases like Toxoplasma. ..