Susan Strome

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. ncbi request reprint Germ versus soma decisions: lessons from flies and worms
    Susan Strome
    Department of Biology, Indiana University, Bloomington, IN 47405, USA
    Science 316:392-3. 2007
  2. pmc MES-4: an autosome-associated histone methyltransferase that participates in silencing the X chromosomes in the C. elegans germ line
    Laurel B Bender
    Department of Biology, Indiana University, Bloomington, IN 47405, USA
    Development 133:3907-17. 2006
  3. pmc Genetic analysis of the Caenorhabditis elegans GLH family of P-granule proteins
    Caroline Spike
    Department of Biology, Indiana University, Bloomington, Indiana 47405, USA
    Genetics 178:1973-87. 2008
  4. pmc Functional analysis of cytoplasmic dynein heavy chain in Caenorhabditis elegans with fast-acting temperature-sensitive mutations
    Diane J Schmidt
    Department of Biology, Indiana University, Bloomington, IN 47405, USA
    Mol Biol Cell 16:1200-12. 2005
  5. pmc DEPS-1 promotes P-granule assembly and RNA interference in C. elegans germ cells
    Caroline A Spike
    Department of Biology, Indiana University, Bloomington, IN 47405, USA
    Development 135:983-93. 2008
  6. pmc Caenorhabditis elegans chromosome arms are anchored to the nuclear membrane via discontinuous association with LEM-2
    Kohta Ikegami
    Department of Biology, Carolina Center for Genome Sciences and Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, 407 Fordham Hall, Chapel Hill, North Carolina 27599, USA
    Genome Biol 11:R120. 2010
  7. pmc Loss of KLP-19 polar ejection force causes misorientation and missegregation of holocentric chromosomes
    James Powers
    Dept of Biology, Indiana University, 1001 E 3rd St, Bloomington, IN 47405, USA
    J Cell Biol 166:991-1001. 2004
  8. ncbi request reprint C. elegans PAR proteins function by mobilizing and stabilizing asymmetrically localized protein complexes
    Rebecca J Cheeks
    Department of Biology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Curr Biol 14:851-62. 2004
  9. ncbi request reprint The MES-2/MES-3/MES-6 complex and regulation of histone H3 methylation in C. elegans
    Laurel B Bender
    Department of Biology, Indiana University, Bloomington, IN 47405, USA
    Curr Biol 14:1639-43. 2004
  10. pmc Regulation of the different chromatin states of autosomes and X chromosomes in the germ line of C. elegans
    Youyi Fong
    Department of Biology, Indiana University, Bloomington, IN 47405, USA
    Science 296:2235-8. 2002

Research Grants

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Germ versus soma decisions: lessons from flies and worms
    Susan Strome
    Department of Biology, Indiana University, Bloomington, IN 47405, USA
    Science 316:392-3. 2007
    ....
  2. pmc MES-4: an autosome-associated histone methyltransferase that participates in silencing the X chromosomes in the C. elegans germ line
    Laurel B Bender
    Department of Biology, Indiana University, Bloomington, IN 47405, USA
    Development 133:3907-17. 2006
    ..We discuss how an autosomally associated HMT may participate in silencing genes on the X chromosome, in coordination with the direct silencing effects of the other MES proteins...
  3. pmc Genetic analysis of the Caenorhabditis elegans GLH family of P-granule proteins
    Caroline Spike
    Department of Biology, Indiana University, Bloomington, Indiana 47405, USA
    Genetics 178:1973-87. 2008
    ..We discuss the evolution of the Vasa/GLH genes and current views of their functions and the assembly and roles of germ granules among species...
  4. pmc Functional analysis of cytoplasmic dynein heavy chain in Caenorhabditis elegans with fast-acting temperature-sensitive mutations
    Diane J Schmidt
    Department of Biology, Indiana University, Bloomington, IN 47405, USA
    Mol Biol Cell 16:1200-12. 2005
    ..This suggests that temperature-sensitive mutations can be created for time-resolved function analyses of dyneins and perhaps other P-loop proteins in a variety of model systems...
  5. pmc DEPS-1 promotes P-granule assembly and RNA interference in C. elegans germ cells
    Caroline A Spike
    Department of Biology, Indiana University, Bloomington, IN 47405, USA
    Development 135:983-93. 2008
    ....
  6. pmc Caenorhabditis elegans chromosome arms are anchored to the nuclear membrane via discontinuous association with LEM-2
    Kohta Ikegami
    Department of Biology, Carolina Center for Genome Sciences and Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, 407 Fordham Hall, Chapel Hill, North Carolina 27599, USA
    Genome Biol 11:R120. 2010
    ..Although Caenorhabditis elegans was the first multicellular organism with a completely sequenced genome, how this genome is arranged within the nucleus is not known...
  7. pmc Loss of KLP-19 polar ejection force causes misorientation and missegregation of holocentric chromosomes
    James Powers
    Dept of Biology, Indiana University, 1001 E 3rd St, Bloomington, IN 47405, USA
    J Cell Biol 166:991-1001. 2004
    ....
  8. ncbi request reprint C. elegans PAR proteins function by mobilizing and stabilizing asymmetrically localized protein complexes
    Rebecca J Cheeks
    Department of Biology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Curr Biol 14:851-62. 2004
    ..Here we use a combination of genetics and live imaging methods in the model organism Caenorhabditis elegans to dissect the cellular mechanisms by which PAR proteins polarize cells...
  9. ncbi request reprint The MES-2/MES-3/MES-6 complex and regulation of histone H3 methylation in C. elegans
    Laurel B Bender
    Department of Biology, Indiana University, Bloomington, IN 47405, USA
    Curr Biol 14:1639-43. 2004
    ..Our results contribute to understanding the composition and roles of E(Z)/MES-2 complexes across species...
  10. pmc Regulation of the different chromatin states of autosomes and X chromosomes in the germ line of C. elegans
    Youyi Fong
    Department of Biology, Indiana University, Bloomington, IN 47405, USA
    Science 296:2235-8. 2002
    ..We propose that all four MES proteins participate in X-chromosome silencing, and that the role of MES-4 is to exclude repressors from the autosomes, thus enabling efficient repression of the Xs...
  11. ncbi request reprint Germ plasm: protein degradation in the soma
    Caroline A Spike
    Department of Biology, Indiana University, Bloomington 47405 3700, USA
    Curr Biol 13:R837-9. 2003
    ..Recent results suggest that, in Caenorhabditis elegans, germ plasm is also prevented from accumulating in somatic lineages by a ubiquitin ligase that targets germ plasm proteins for degradation...
  12. pmc Subunit contributions to histone methyltransferase activities of fly and worm polycomb group complexes
    Carrie S Ketel
    Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, 55455, USA
    Mol Cell Biol 25:6857-68. 2005
    ..Thus, although the fly and mammalian PcG complexes absolutely require SU(Z)12, the worm complex generates HMTase activity from a distinct partner set...
  13. pmc MRG-1, an autosome-associated protein, silences X-linked genes and protects germline immortality in Caenorhabditis elegans
    Teruaki Takasaki
    Department of Biology, Graduate School of Science and Technology, Kobe University, 1 1 Rokkodaicho, Nadaku, Kobe 657 8501, Japan
    Development 134:757-67. 2007
    ..We discuss how an autosome-enriched protein might repress genes on the X chromosome, promote PGC proliferation and survival, and influence the germ versus soma distinction...
  14. pmc Kinesin-5 acts as a brake in anaphase spindle elongation
    Adam M Saunders
    Curr Biol 17:R453-4. 2007
  15. pmc A map of the interactome network of the metazoan C. elegans
    Siming Li
    Dana Farber Cancer Institute and Department of Genetics, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Science 303:540-3. 2004
    ..Topological and biological features of this interactome network, as well as its integration with phenome and transcriptome data sets, lead to numerous biological hypotheses...
  16. pmc The PGL family proteins associate with germ granules and function redundantly in Caenorhabditis elegans germline development
    Ichiro Kawasaki
    PRESTO, Japan Science and Technology Agency, Kawaguchi, Saitama 332 0012, Japan
    Genetics 167:645-61. 2004
    ..Our findings demonstrate that both PGL-2 and PGL-3 are components of P granules, both interact with PGL-1, and at least PGL-3 functions redundantly with PGL-1 to ensure fertility in both sexes of C. elegans...
  17. pmc KLP-18, a Klp2 kinesin, is required for assembly of acentrosomal meiotic spindles in Caenorhabditis elegans
    Christoph Segbert
    Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, 40225 Dusseldorf, Germany
    Mol Biol Cell 14:4458-69. 2003
    ....

Research Grants1

  1. Control of Early Germline Development in C. elegans
    Susan Strome; Fiscal Year: 2007
    ..Our studies will make important contributions to understanding control of chromatin states, mechanisms for discriminating between the autosomes and the sex chromosomes, and specific chromatin requirements in germ cells. ..