Edward F Srour

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. ncbi request reprint FOXA1 expression in breast cancer--correlation with luminal subtype A and survival
    Sunil Badve
    Department of Pathology, Indiana University School of Medicine, Indianapolis, USA
    Clin Cancer Res 13:4415-21. 2007
  2. pmc Molecular analysis of thymoma
    Sunil Badve
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
    PLoS ONE 7:e42669. 2012
  3. pmc Persistent upregulation of U6:SNORD44 small RNA ratio in the serum of breast cancer patients
    Hitesh N Appaiah
    Department of Surgery, Indiana University School of Medicine, West Walnut Street, Indianapolis, IN 46202, USA
    Breast Cancer Res 13:R86. 2011
  4. doi request reprint Breast-cancer stem cells-beyond semantics
    Sunil Badve
    Department of Pathology and Laboratory Medicine, Indiana University Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Lancet Oncol 13:e43-8. 2012
  5. pmc Breast cancer prognostic classification in the molecular era: the role of histological grade
    Emad A Rakha
    Department of Histopathology, Nottingham City Hospital NHS Trust, Nottingham University, Nottingham, UK
    Breast Cancer Res 12:207. 2010
  6. pmc CD44+/CD24- breast cancer cells exhibit enhanced invasive properties: an early step necessary for metastasis
    Carol Sheridan
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Breast Cancer Res 8:R59. 2006
  7. pmc Expression of androgen receptor and prostate-specific antigen in male breast carcinoma
    Noman Kidwai
    Northwestern University Medical School, Chicago, IL, USA
    Breast Cancer Res 6:R18-23. 2004
  8. pmc The diagnosis and management of pre-invasive breast disease: another point of view
    Sunil Badve
    Breast Cancer Res 6:E3; discussion E4. 2004
  9. pmc Subcellular localization of activated AKT in estrogen receptor- and progesterone receptor-expressing breast cancers: potential clinical implications
    Sunil Badve
    Department of Pathology and Internal Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Am J Pathol 176:2139-49. 2010
  10. ncbi request reprint Small cells in hepatoblastoma lack "oval" cell phenotype
    S Badve
    Department of Pathology, Indiana University, Indianapolis, Indiana, USA
    Mod Pathol 16:930-6. 2003

Collaborators

Detail Information

Publications96

  1. ncbi request reprint FOXA1 expression in breast cancer--correlation with luminal subtype A and survival
    Sunil Badve
    Department of Pathology, Indiana University School of Medicine, Indianapolis, USA
    Clin Cancer Res 13:4415-21. 2007
    ..It segregates with genes that characterize the luminal subtypes in DNA microarray analyses. The utility of FOXA1 as a possible independent prognostic factor has not been determined in breast cancers...
  2. pmc Molecular analysis of thymoma
    Sunil Badve
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
    PLoS ONE 7:e42669. 2012
    ..A number of potential candidates for therapeutics were also identified...
  3. pmc Persistent upregulation of U6:SNORD44 small RNA ratio in the serum of breast cancer patients
    Hitesh N Appaiah
    Department of Surgery, Indiana University School of Medicine, West Walnut Street, Indianapolis, IN 46202, USA
    Breast Cancer Res 13:R86. 2011
    ..This investigation addresses two issues that impact their utility: a) appropriate normalization controls and b) whether their altered levels persist in patients who are clinically free of the disease...
  4. doi request reprint Breast-cancer stem cells-beyond semantics
    Sunil Badve
    Department of Pathology and Laboratory Medicine, Indiana University Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Lancet Oncol 13:e43-8. 2012
    ..We also argue that the cell-type origin of cancer could affect the rate at which CSCs develop in a tumour, with an eventual effect on disease outcome...
  5. pmc Breast cancer prognostic classification in the molecular era: the role of histological grade
    Emad A Rakha
    Department of Histopathology, Nottingham City Hospital NHS Trust, Nottingham University, Nottingham, UK
    Breast Cancer Res 12:207. 2010
    ....
  6. pmc CD44+/CD24- breast cancer cells exhibit enhanced invasive properties: an early step necessary for metastasis
    Carol Sheridan
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Breast Cancer Res 8:R59. 2006
    ..The aim of this study was to investigate whether this subpopulation of cancer cells has the unique ability to invade, home, and proliferate at sites of metastasis...
  7. pmc Expression of androgen receptor and prostate-specific antigen in male breast carcinoma
    Noman Kidwai
    Northwestern University Medical School, Chicago, IL, USA
    Breast Cancer Res 6:R18-23. 2004
    ..However, expression of these two proteins in tumors arising in tissues regulated by androgens such as male breast carcinoma has not been thoroughly evaluated...
  8. pmc The diagnosis and management of pre-invasive breast disease: another point of view
    Sunil Badve
    Breast Cancer Res 6:E3; discussion E4. 2004
  9. pmc Subcellular localization of activated AKT in estrogen receptor- and progesterone receptor-expressing breast cancers: potential clinical implications
    Sunil Badve
    Department of Pathology and Internal Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Am J Pathol 176:2139-49. 2010
    ..These results suggest that subcellular localization of activated AKT plays a significant role in determining its function in breast cancer, which in part is dependent on TCL1B expression...
  10. ncbi request reprint Small cells in hepatoblastoma lack "oval" cell phenotype
    S Badve
    Department of Pathology, Indiana University, Indianapolis, Indiana, USA
    Mod Pathol 16:930-6. 2003
    ..the liver have two different types of progenitor cells, oval cells and blastemal cells, with differing immunophenotypes? and (4) do the blastemal cells, rather than oval cells, represent the more primitive progenitor cells of the liver?..
  11. doi request reprint Basal-like and triple-negative breast cancers: a critical review with an emphasis on the implications for pathologists and oncologists
    Sunil Badve
    Clarian Pathology Lab, Department of Pathology and Internal Medicine, Indiana University, Indianapolis, USA
    Mod Pathol 24:157-67. 2011
    ....
  12. doi request reprint Oestrogen-receptor-positive breast cancer: towards bridging histopathological and molecular classifications
    S Badve
    Department of Pathology and Laboratory Medicine, and Internal Medicine, Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN, USA
    J Clin Pathol 62:6-12. 2009
    ..A detailed understanding of these areas will permit better classification and a personalised approach to management of ER-positive breast cancers...
  13. doi request reprint Estrogen- and progesterone-receptor status in ECOG 2197: comparison of immunohistochemistry by local and central laboratories and quantitative reverse transcription polymerase chain reaction by central laboratory
    Sunil S Badve
    Eastern Cooperative Oncology Group, Boston, MA, USA
    J Clin Oncol 26:2473-81. 2008
    ....
  14. ncbi request reprint Ductal lavage and its histopathologic basis: a cautionary tale
    Sunil Badve
    Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Diagn Cytopathol 30:166-71. 2004
    ..Further studies, preferably controlled clinical trials, are necessary before routine use of the procedure can be recommended...
  15. pmc Impact of maturational status on the ability of osteoblasts to enhance the hematopoietic function of stem and progenitor cells
    Ying Hua Cheng
    Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Bone Miner Res 26:1111-21. 2011
    ....
  16. pmc AMD3100 synergizes with G-CSF to mobilize repopulating stem cells in Fanconi anemia knockout mice
    Anna C Pulliam
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA
    Exp Hematol 36:1084-90. 2008
    ....
  17. pmc Impact of interactions of cellular components of the bone marrow microenvironment on hematopoietic stem and progenitor cell function
    Brahmananda R Chitteti
    Departments of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Blood 115:3239-48. 2010
    ..These data illustrate that OBs promote in vitro maintenance of hematopoietic functions, including repopulating potential by up-regulating Notch-mediated signaling between HSCs and OBs...
  18. pmc Hierarchical organization of osteoblasts reveals the significant role of CD166 in hematopoietic stem cell maintenance and function
    Brahmananda R Chitteti
    Department of Medicine, Indiana University School of Medicine, Indianapolis, USA
    Bone 54:58-67. 2013
    ..These studies begin to define the hierarchical organization of osteoblastic cells and provide a more refined definition of OB that can mediate HEA...
  19. ncbi request reprint Skeletal muscle-derived progenitor cells exhibit neural competence
    Takako Kondo
    Department of Otolaryngology, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Neuroreport 17:1-4. 2006
    ..These results reveal unexpected potentials of muscle progenitor cells and suggest that these cells may potentially be used in cell-based therapies to replace damaged neurons...
  20. pmc SLUG/SNAI2 and tumor necrosis factor generate breast cells with CD44+/CD24- phenotype
    Poornima Bhat-Nakshatri
    Department of Surgery, Indiana University School of Medicine, West Walnut Street, Indianapolis, IN 46202, USA
    BMC Cancer 10:411. 2010
    ..However, whether all genes that induce EMT confer the CD44+/CD24- phenotype is unknown. We hypothesized that only a subset of genes associated with EMT generates CD44+/CD24- cells...
  21. pmc Genomic and proteomic analysis of the impact of mitotic quiescence on the engraftment of human CD34+ cells
    Brahmananda Reddy Chitteti
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
    PLoS ONE 6:e17498. 2011
    ....
  22. ncbi request reprint Clonal multilineage differentiation of murine common pluripotent stem cells isolated from skeletal muscle and adipose stromal cells
    Jamie Case
    Indiana University School of Medicine, Cancer Research Institute, 1044 West Walnut Street, R4 202, Indianapolis, IN 46202, USA
    Ann N Y Acad Sci 1044:183-200. 2005
    ..Taken together, these data demonstrate that a common PSC can be identified in different murine tissues and suggest that a small fraction of these cells are capable of clonal differentiation into multiple cell types...
  23. pmc Identification of parameters required for efficient lentiviral vector transduction and engraftment of human cord blood CD34(+) NOD/SCID-repopulating cells
    Ying Liu
    Department of Microbiology and Immunology and the Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Exp Hematol 36:947-56. 2008
    ..To optimize culture and transduction conditions, we compared various lengths of time for prestimulation before transduction, transduction duration, and posttransduction cell culture...
  24. pmc In vitro clonal analysis of murine pluripotent stem cells isolated from skeletal muscle and adipose stromal cells
    Jamie Case
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Exp Hematol 36:224-34. 2008
    ..In the present study, the clonal in vitro differentiation potential of two isolates of PSCs was examined...
  25. ncbi request reprint A role for the Fanconi anemia C protein in maintaining the DNA damage-induced G2 checkpoint
    Brian W Freie
    Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 279:50986-93. 2004
    ....
  26. pmc Osteoblast lineage cells expressing high levels of Runx2 enhance hematopoietic progenitor cell proliferation and function
    Brahmananda R Chitteti
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Cell Biochem 111:284-94. 2010
    ....
  27. pmc Regulation of murine hematopoietic stem cell quiescence by Dmtf1
    Michihiro Kobayashi
    Department of Medicine, Indiana University School of Medicine, 980 West Walnut St, Indianapolis, IN 46202, USA
    Blood 118:6562-71. 2011
    ..The function of Dmtf1 was mediated by both Arf-dependent and Arf-independent pathways. Our results implicate Dmtf1 in the regulation of HSC function through novel cell cycle-regulatory mechanisms...
  28. ncbi request reprint Decreased homing of retrovirally transduced human bone marrow CD34+ cells in the NOD/SCID mouse model
    Kristin M Hall
    Department of Microbiology and Immunology, Division of Hematology Oncology, Indian University School of Medicine, Indianapolis, 46202, USA
    Exp Hematol 34:433-42. 2006
    ..Because engraftment is dependent upon successful homing of graft cells to the bone marrow (BM), we examined whether retroviral-mediated gene transfer (RMGT) induces a homing defect in CD34(+) cells...
  29. doi request reprint In vitro construction of 2D and 3D simulations of the murine hematopoietic niche
    Brahmananda Reddy Chitteti
    Division of Hematology Oncology, Indiana University School of Medicine, Indianapolis, IN, USA
    Methods Mol Biol 1035:43-56. 2013
    ....
  30. pmc The changing balance between osteoblastogenesis and adipogenesis in aging and its impact on hematopoiesis
    Monique Bethel
    Department of Orthopaedic Surgery, Indiana University School of Medicine, 1120 South Drive, FH 115, Indianapolis, IN 46202, USA
    Curr Osteoporos Rep 11:99-106. 2013
    ..This review will examine the current knowledge of how adipogenesis and osteogenesis change with aging and the implications of this changing environment on hematopoeisis...
  31. pmc Estradiol-regulated microRNAs control estradiol response in breast cancer cells
    Poornima Bhat-Nakshatri
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
    Nucleic Acids Res 37:4850-61. 2009
    ..Additionally, our studies reveal a negative-regulatory loop controlling E2 response through microRNAs as well as differences in E2-induced transcriptome and proteome...
  32. ncbi request reprint Prostanoid receptor EP1 expression in breast cancer
    Mangesh A Thorat
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Mod Pathol 21:15-21. 2008
    ..059). Expression of EP1 is frequently seen in human breast cancers. Nuclear expression of EP1 correlates with good prognosis markers like node negative status and PR expression...
  33. doi request reprint Prognostic impact of ALDH1 in breast cancer: a story of stem cells and tumor microenvironment
    Erika Resetkova
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 46202, USA
    Breast Cancer Res Treat 123:97-108. 2010
    ..The novel finding is that tumor microenvironment may play a significant role in determining the prognostic impact of stem/progenitor cells in human breast tumors...
  34. pmc Pyk2 regulates megakaryocyte-induced increases in osteoblast number and bone formation
    Ying Hua Cheng
    Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
    J Bone Miner Res 28:1434-45. 2013
    ..Further understanding of the signaling pathways involved in the MK-mediated enhancement of OB number and bone formation will facilitate the development of novel anabolic therapies to treat bone loss diseases...
  35. pmc Differential stem- and progenitor-cell trafficking by prostaglandin E2
    Jonathan Hoggatt
    Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Nature 495:365-9. 2013
    ..These results not only uncover unique regulatory roles for EP4 signalling in HSC retention in the niche, but also define a rapidly translatable strategy to enhance transplantation therapeutically...
  36. pmc Angiopoietin-like-2 and -3 act through their coiled-coil domains to enhance survival and replating capacity of human cord blood hematopoietic progenitors
    Hal E Broxmeyer
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202 5181, USA
    Blood Cells Mol Dis 48:25-9. 2012
    ..Thus, among ANGPTL family members, ANGPTL-2 and -3 had enhancing activities on human HPC survival and replating activity, effects requiring the CC domain of the ANGPTL molecules. This information is of relevance to hu HPC regulation...
  37. ncbi request reprint Breast cancer stem cells and intrinsic subtypes: controversies rage on
    Harikrishna Nakshatri
    Department of Surgery, Indiana University School of Medicine, 1044 West Walnut Street, Indianapolis, IN 46202, USA
    Curr Stem Cell Res Ther 4:50-60. 2009
    ....
  38. pmc Antibody targeting KIT as pretransplantation conditioning in immunocompetent mice
    Xingkui Xue
    Herman B Wells Center for Pediatric Research, Department of Pediatrics, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN, USA
    Blood 116:5419-22. 2010
    ..We conclude that combining ACK2 with LD-IR is a promising approach to effectively deplete endogenous HSCs and facilitate engraftment of transplanted donor HSCs...
  39. pmc Dipeptidylpeptidase 4 negatively regulates colony-stimulating factor activity and stress hematopoiesis
    Hal E Broxmeyer
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Nat Med 18:1786-96. 2012
    ..DPP4 inhibition enhanced engraftment in mice without compromising HSC function, suggesting the potential clinical utility of this approach...
  40. ncbi request reprint Flow cytometric analysis of hematopoietic development
    Edward F Srour
    Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA
    Methods Mol Med 105:65-80. 2005
    ..This plasticity of the HSCs demonstrates hemangioblast activity, proven by both single cell and serial HSC transplants, and is the focus of this chapter...
  41. ncbi request reprint A murine model of antimetabolite-based, submyeloablative conditioning for bone marrow transplantation: biologic insights and potential applications
    W Scott Goebel
    Herman B Wells Center for Pediatric Research and Department of Pediatrics, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Ind, USA
    Exp Hematol 32:1255-64. 2004
    ....
  42. ncbi request reprint Negative regulation of MHC class II gene expression by CXCR4
    Carol Sheridan
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Exp Hematol 34:1085-92. 2006
    ..We have initiated a study aimed at dissecting additional functions of CXCR4 in cancer cells, particularly in relation to the immune system...
  43. pmc Rapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonist
    Hal E Broxmeyer
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Exp Med 201:1307-18. 2005
    ..These results support the hypothesis that the CXCL12-CXCR4 axis is involved in marrow retention of HSCs and HPCs, and demonstrate the clinical potential of AMD3100 for HSC mobilization...
  44. ncbi request reprint Pluripotent stem cells identified in multiple murine tissues
    Jonathan C Howell
    Division of Hematology Oncology and Indiana Elks Cancer Research Center, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Ann N Y Acad Sci 996:158-73. 2003
    ..These studies suggest that a phenotypically common, multipotent cell can be identified in different tissues and that this cell may represent a universal pluripotent stem cell residing at different levels in multiple murine tissues...
  45. pmc Hematopoietic cell regulation of osteoblast proliferation and differentiation
    Monique Bethel
    Department of Orthopaedic Surgery, Indiana University School of Medicine, 1120 South Drive, FH 115, Indianapolis, IN 46202, USA
    Curr Osteoporos Rep 9:96-102. 2011
    ..Specifically, we will examine the impact of hematopoietic cells such as HSCs, lymphocytes, and megakaryocytes, as well as the hematopoietic cell-derived OCs on OB proliferation, differentiation, and function...
  46. pmc Application of polychromatic flow cytometry to identify novel subsets of circulating cells with angiogenic potential
    Myka L Estes
    Department of Pediatrics, Indiana University, Indianapolis, Indiana, USA
    Cytometry A 77:831-9. 2010
    ..In sum, a PFC protocol validated via in vitro and in vivo analyses, can be used to interrogate the roles of human hematopoietic elements in the growth and maintenance of the vasculature...
  47. doi request reprint CD166 and regulation of hematopoiesis
    Brahmananda R Chitteti
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Curr Opin Hematol 20:273-80. 2013
    ..Recently, a few laboratories, including ours, recognized the importance of CD166 as a functional marker on both stem cells and osteoblasts and have begun to characterize the role of CD166 in hematopoiesis...
  48. pmc The SKP2 E3 ligase regulates basal homeostasis and stress-induced regeneration of HSCs
    Sonia Rodriguez
    Department of Pediatrics, Herman B Wells Center, Indiana University Simon Cancer Center, Indiana University School of Medicine, 1044 W Walnut, Indianapolis, IN 46202, USA
    Blood 117:6509-19. 2011
    ..Our results demonstrate a previously unrecognized role for SKP2 in regulating HSC and progenitor expansion and hematopoietic regeneration after stress...
  49. ncbi request reprint Modulation of in vitro proliferation kinetics and primitive hematopoietic potential of individual human CD34+CD38-/lo cells in G0
    Edward F Srour
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Blood 105:3109-16. 2005
    ..These data suggest that although exit from quiescence and commitment to proliferation might be stochastic, kinetics of proliferation, and possibly fate of primitive HPCs, might be modulated by extrinsic factors...
  50. ncbi request reprint Lymphangiogenesis does not occur in breast cancer
    Beamon Agarwal
    Department of Pathology, Indiana University School of Medicine, Indianapolis, IN, USA
    Am J Surg Pathol 29:1449-55. 2005
    ..This was in contrast to the strong expression seen in adjacent tumor cells and blood vessel endothelial cells. Thus, lymphangiogenesis was not evident when studied by lymphatic vessel density or by lymph vessel endothelial proliferation...
  51. pmc Effects of HIV protease inhibitor ritonavir on Akt-regulated cell proliferation in breast cancer
    Anjaiah Srirangam
    Department of Medicine, Indiana University, Indianapolis, Indiana 46202, USA
    Clin Cancer Res 12:1883-96. 2006
    ..Ritonavir may be of interest for breast cancer therapeutics and its efficacy may be increased by sustained exposure or Hsp90 RNA interference...
  52. ncbi request reprint Fanconi anemia type C-deficient hematopoietic stem/progenitor cells exhibit aberrant cell cycle control
    Xiaxin Li
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202 5254
    Blood 102:2081-4. 2003
    ..Collectively, these data provide a previously unrecognized phenotype in Fancc-/- hematopoietic stem/progenitor cells, which may contribute to the progressive bone marrow failure in Fanconi anemia...
  53. pmc Adult bone marrow-derived cells do not acquire functional attributes of cardiomyocytes when transplanted into peri-infarct myocardium
    John A Scherschel
    Department of Pediatrics, Division of Cardiology, Wells Center for Pediatric Research, Indianapolis, Indiana 46202, USA
    Mol Ther 16:1129-37. 2008
    ..We conclude that engrafted BM-derived cells lack attributes of functioning cardiomyocytes, calling into question the concept that adult BM cells can give rise to substantive cardiomyocyte regeneration within the infarcted heart...
  54. doi request reprint Differential subcellular expression of protein kinase C betaII in breast cancer: correlation with breast cancer subtypes
    Yesim Gokmen-Polar
    Department of Medicine, Indiana University School of Medicine, Walther Hall, 980 W Walnut Street, C230, Indianapolis, IN 46202, USA
    Breast Cancer Res Treat 124:327-35. 2010
    ..Our study suggests the necessity for assessing the subcellular localization of PKCβII in breast cancer subtypes when evaluating the possible effectiveness of PKCβII-targeting agents...
  55. ncbi request reprint A physiologic imaging pilot study of breast cancer treated with AZD2171
    Kathy D Miller
    Division of Hematology and Oncology, Department of Medicine, Indiana University, Indianapolis, IN 46202, USA
    Clin Cancer Res 12:281-8. 2006
    ....
  56. doi request reprint Prognostic indicators after surgery for thymoma
    Ikenna C Okereke
    Department of Surgery Cardiothoracic Division, Indiana University School of Medicine, Indianapolis, Indiana 46204, USA
    Ann Thorac Surg 89:1071-7; discussion 1077-9. 2010
    ..We undertook a 20-year retrospective institutional study to investigate prognostic indicators after surgery for thymoma...
  57. ncbi request reprint FOXA1 as a therapeutic target for breast cancer
    Harikrishna Nakshatri
    Indiana University School of Medicine, Departments of Surgery, Biochemistry and Molecular Biology, Walther Oncology Center, Indianapolis, IN 46202, USA
    Expert Opin Ther Targets 11:507-14. 2007
    ..This article reviews possible roles of FOXA family transcription factors in breast cancer initiation, hormone dependency and speculates on the potential of FOXA1 as a therapeutic target...
  58. ncbi request reprint A Mexican man with "too much blood"
    Montaser Shaheen
    Department of Medicine, Indiana University School of Medicine Indianapolis, IN 46202, USA
    Lancet 362:806. 2003
  59. ncbi request reprint A novel biomarker for the detection of esophageal adenocarcinoma
    Zane T Hammoud
    Thoracic Surgery Division, Department of Surgery, Indiana University School of Medicine, Indianapolis, Ind, USA
    J Thorac Cardiovasc Surg 133:82-7. 2007
    ..We sought to determine the presence of cancer-specific proliferating cell nuclear antigen in esophageal dysplasias and invasive adenocarcinomas to assess its potential utility in discriminating malignancy...
  60. doi request reprint Podoplanin, a novel marker for seminoma: A comparison study evaluating immunohistochemical expression of podoplanin and OCT3/4
    Muhammad Idrees
    Department of Pathology, Indiana University School of Medicine, Indianapolis, 46202, USA
    Ann Diagn Pathol 14:331-6. 2010
    ..The identification by podoplanin of seminoma cells lying adjacent to foci of embryonal carcinoma gives credence to the hypothesis that the latter arise from seminomas as part of a process of "differentiation."..
  61. doi request reprint Differential gene expression profiling of esophageal adenocarcinoma
    Zane T Hammoud
    Department of Surgery, Thoracic Surgery Division, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Thorac Cardiovasc Surg 137:829-34. 2009
    ....
  62. ncbi request reprint Randomized phase II trial of the anti-angiogenic potential of doxorubicin and docetaxel; primary chemotherapy as Biomarker Discovery Laboratory
    Kathy D Miller
    Division of Hematology and Oncology, Indiana University, Indianapolis, IN, USA
    Breast Cancer Res Treat 89:187-97. 2005
    ..Primary chemotherapy provides an ideal opportunity to correlate potential non-invasive surrogate markers of angiogenesis with tumor microvessel density (MVD) and response...
  63. doi request reprint Lymphatic vessel density in radical prostatectomy specimens
    Liang Cheng
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Hum Pathol 39:610-5. 2008
    ..In contrast to other malignancies, quantitation of lymphangiogenesis in prostatic adenocarcinoma does not appear to offer useful prognostic information...
  64. doi request reprint Sebaceous carcinoma of the nipple
    Thomas L Cibull
    IUMC Clarian Pathology Laboratory 350 West 11th Street, Indianapolis, IN 46202, USA
    J Cutan Pathol 35:608-10. 2008
    ..We report a case of an 83-year-old woman with SC of the nipple. To our knowledge, this is the first report of SC arising in the nipple...
  65. pmc Prognosis of hormone-dependent breast cancers: implications of the presence of dysfunctional transcriptional networks activated by insulin via the immune transcription factor T-bet
    Kasi McCune
    Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Cancer Res 70:685-96. 2010
    ....
  66. pmc Association of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 genetic polymorphisms with outcome in a trial of paclitaxel compared with paclitaxel plus bevacizumab in advanced breast cancer: ECOG 2100
    Bryan P Schneider
    Indiana University School of Medicine, Indianapolis, IN, USA
    J Clin Oncol 26:4672-8. 2008
    ..Therefore, we evaluated the association of VEGF genotype with efficacy and toxicity in E2100, a phase III study comparing paclitaxel versus paclitaxel plus bevacizumab as initial chemotherapy for metastatic breast cancer...
  67. pmc AKT alters genome-wide estrogen receptor alpha binding and impacts estrogen signaling in breast cancer
    Poornima Bhat-Nakshatri
    Department of Surgery, Indiana University School of Medicine, 1044 West Walnut St, Indianapolis, IN 46202, USA
    Mol Cell Biol 28:7487-503. 2008
    ....
  68. doi request reprint FOXA1 in breast cancer
    Harikrishna Nakshatri
    Departments of Surgery, Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Expert Rev Mol Med 11:e8. 2009
    ..Additionally, we discuss modulators of FOXA1 function, ERalpha-FOXA1-GATA3 downstream targets, and potential therapeutic agents that may increase differentiation through FOXA1...
  69. ncbi request reprint The sesquiterpene lactone parthenolide in combination with docetaxel reduces metastasis and improves survival in a xenograft model of breast cancer
    Christopher J Sweeney
    Department of Medicine, Indiana University School of Medicine, Indianapolis, USA
    Mol Cancer Ther 4:1004-12. 2005
    ..These results for the first time reveal the significant in vivo chemosensitizing properties of parthenolide in the metastatic breast cancer setting and support the contention that metastases are very reliant on activation of NF-kappaB...
  70. ncbi request reprint Immunolocalization of low-affinity prostaglandin E receptors, EP and EP, in adult human epidermis
    Raymond L Konger
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Invest Dermatol 124:965-70. 2005
    ..In cultured primary human keratinocytes, we also verified the presence of functional EP(1) receptor coupled to intracellular calcium mobilization and EP(2) receptor coupled to cAMP production...
  71. doi request reprint Pro-inflammatory angiogenesis is mediated by p38 MAP kinase
    Gangaraju Rajashekhar
    Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Cell Physiol 226:800-8. 2011
    ....
  72. ncbi request reprint Analysis of angiogenesis genes from paraffin-embedded breast tumor and lymph nodes
    Bryan P Schneider
    Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA
    Breast Cancer Res Treat 96:209-15. 2006
    ..These genes include vascular endothelial growth factor (VEGF) and endothelial nitric oxide synthase (eNOS)...
  73. doi request reprint COX-2 expression does not correlate with microvessel density in breast cancer
    Mangesh A Thorat
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Pathobiology 76:39-44. 2009
    ..The exact mechanism of such action is not known and the clinical evidence of such interaction is weak. We studied COX-2 expression and microvessel density (MVD) in malignant breast tissues...
  74. pmc Prognostic utility of the 21-gene assay in hormone receptor-positive operable breast cancer compared with classical clinicopathologic features
    Lori J Goldstein
    Eastern Cooperative Oncology Group, Boston, MA, USA
    J Clin Oncol 26:4063-71. 2008
    ..Genomic classifiers offer the potential to more accurately identify individuals who benefit from chemotherapy than clinicopathologic features...
  75. doi request reprint Expression of Forkhead-box protein A1, a marker of luminal A type breast cancer, parallels low Oncotype DX 21-gene recurrence scores
    Foluso O Ademuyiwa
    Department of Medicine, Indiana University, School of Medicine, Indianapolis, IN 46202, USA
    Mod Pathol 23:270-5. 2010
    ..To confirm these findings, further studies in a larger cohort of patients are warranted...
  76. pmc A cancer-associated PCNA expressed in breast cancer has implications as a potential biomarker
    Linda H Malkas
    Division of Hematology and Oncology, Indiana University School of Medicine, and Indiana Cancer Center, Indianapolis, IN 46202, USA
    Proc Natl Acad Sci U S A 103:19472-7. 2006
    ..Our studies indicate that the caPCNA isoform may be a previously uncharacterized detector of breast cancer...
  77. ncbi request reprint Role of E-cadherins in development of lymphatic tumor emboli
    Anita Gupta
    Department of Pathology, Northwestern University, Chicago, Illinois, USA
    Cancer 97:2341-7. 2003
    ..In the current study, the authors assessed E-cad expression in cases of IDC with and without intralymphatic tumor emboli to examine the potential role played by these molecules in the development of lymphatic emboli...
  78. ncbi request reprint Muscle-derived CD45-SCA-1+c-kit- progenitor cells give rise to skeletal muscle myotubes in vitro
    Cassandre L Royer
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    In Vitro Cell Dev Biol Anim 38:512-7. 2002
    ..Both populations possess the ability to differentiate into skeletal muscle cells in vitro...
  79. doi request reprint High-level expression of forkhead-box protein A1 in metastatic prostate cancer
    Rohit K Jain
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Histopathology 58:766-72. 2011
    ..The aim of this study was to investigate the expression and potential role of FOXA1 and GATA3 transcription factors as prognostic factors in prostate cancer...
  80. doi request reprint Estrogen promotes tumor progression in a genetically defined mouse model of lung adenocarcinoma
    Zane Hammoud
    Department of Obstetrics and Gynecology, Indiana University School of Medicine, 975 West Walnut Street IB360, Indianapolis, Indiana 46202 5121, USA
    Endocr Relat Cancer 15:475-83. 2008
    ..In conclusion, estrogen acts as a promoter for lung adenocarcinoma in a genetically defined lung cancer model; estrogen-induced cell proliferation in the oncogene-initiated cells is likely to play a role in this tumor promoter activity...
  81. ncbi request reprint Predicting response to primary chemotherapy: gene expression profiling of paraffin-embedded core biopsy tissue
    Lida Mina
    Department of Medicine, Indiana University, RT 473, Indianapolis, IN, 46202, USA
    Breast Cancer Res Treat 103:197-208. 2007
    ..We used paraffin-embedded core biopsies from a completed phase II trial to identify genes that correlate with response to primary chemotherapy...
  82. ncbi request reprint Microsomal prostaglandin E2 synthase-1 in breast cancer: a potential target for therapy
    Sanjana Mehrotra
    Department of Pathology, Indiana University, Indianapolis, Indiana 46202, USA
    J Pathol 208:356-63. 2006
    ..In this study, coordinate over-expression of COX-2 and mPGES-1 was not observed, particularly in the endothelial cells of blood vessels. Targeting mPGES-1 might prove to be an alternative therapeutic strategy to inhibit PGE2 production...
  83. ncbi request reprint Telomerase template antagonist GRN163L disrupts telomere maintenance, tumor growth, and metastasis of breast cancer
    Amelia E Hochreiter
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202 5251, USA
    Clin Cancer Res 12:3184-92. 2006
    ..The aim of this study was to address the breast cancer translational potential of the novel telomerase inhibitor, GRN163L...
  84. ncbi request reprint Expression of cytokeratin 20 in mucinous bronchioloalveolar carcinoma
    Rajshri N Shah
    Department of Pathology, Northwestern University, Chicago, IL 60611, USA
    Hum Pathol 33:915-20. 2002
    ..Although the CK7/CK20 immunoprofile is a valuable diagnostic marker for differentiating primary lung adenocarcinoma from metastatic colonic adenocarcinoma, caution should be exercised when dealing with mucinous BAC...
  85. ncbi request reprint Benign glandular inclusions a rare cause of a false positive sentinel node
    Laura E Norton
    Section of Breast Surgical Oncology, Indiana University, Indianapolis, Indiana, USA
    J Surg Oncol 95:593-6. 2007
    ..The limitations of intra-operative evaluation of sentinel nodes make differentiation of uncommon pathology difficult. A conservative approach should be taken with these lesions as permanent sections will often elucidate the diagnosis...
  86. ncbi request reprint Radiation pneumonitis in mice: a severe injury model for pneumocyte engraftment from bone marrow
    Neil D Theise
    Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
    Exp Hematol 30:1333-8. 2002
    ..To better understand the process by which pneumocytes can be derived from bone marrow cells, we investigated the in vivo kinetics of such engraftment following lethal irradiation...
  87. ncbi request reprint Leiomyosarcoma of the penis presenting as a cutaneous lesion
    Thomas L Cibull
    Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN, USA
    J Cutan Pathol 35:585-7. 2008
    ..This is an important diagnosis in the differential diagnosis of cutaneous spindle cell neoplasms of the male genital tract...
  88. ncbi request reprint Loss of BRCA1 expression in sporadic male breast carcinoma
    Xiaoping Sun
    Department of Pathology, Northwestern University Medical School, Chicago, IL, USA
    Breast Cancer Res Treat 71:1-7. 2002
    ..These results suggest that BRCA1 plays a similar role in both male and female breast carcinoma and Joss of this protein is associated with poor prognosis...
  89. ncbi request reprint Breast mass in a patient with ovarian cancer: a case report
    Suresh Gayathri
    Department of Medicine, Indiana University Melvin and Bren Simon Cancer Center, Indiana University School of Medicine, 535 Barnhill Drive, RT 473, Indianapolis, IN 46202, USA
    J Reprod Med 54:639-44. 2009
    ..Gynecologic tumors rarely metastasize to the breast. We report 2 patients who developed a breast mass following a known diagnosis of metastatic ovarian carcinoma or primary peritoneal carcinoma...
  90. ncbi request reprint Effect of time interval on residual disease in breast cancer
    Elizabeth L Wiley
    Lynn Sage Breast Cancer Northwestern Memorial Hospital, Department of Pathology, Northwestern University School of Medicine, Chicago, Illinois, USA
    Am J Surg Pathol 27:194-8. 2003
    ..0043); this decrease was not found associated with ductal carcinoma in situ. These findings suggest that the host response to injury may destroy residual infiltrating carcinoma cells in some margin-positive cases...
  91. pmc Interleukin-1 alpha promotes tumor growth and cachexia in MCF-7 xenograft model of breast cancer
    Suresh Kumar
    Departments of Surgery, Indiana University School of Medicine, Indianapolis 46202, USA
    Am J Pathol 163:2531-41. 2003
    ..Taken together, these results suggest that cancer cell-derived cytokines, such as IL-1 alpha, induce cachexia by affecting leptin-dependent metabolic pathways...
  92. ncbi request reprint Pathologic quiz case: a 42-year-old man with right facial swelling and weakness. Dedifferentiated acinic cell carcinoma of the parotid gland
    Angie M Schultz
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, USA
    Arch Pathol Lab Med 128:e52-3. 2004
  93. ncbi request reprint The macrophage inhibitory cytokine integrates AKT/PKB and MAP kinase signaling pathways in breast cancer cells
    Wyatt Wollmann
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Carcinogenesis 26:900-7. 2005
    ..These results suggest that AKT/PKB through MIC-1 could regulate the ERK1 activity and the MIC-1 expression levels may serve as a surrogate marker for the AKT activation in tumors...
  94. doi request reprint Sulindac prevents carcinogen-induced intrahepatic cholangiocarcinoma formation in vivo
    Sabrina C Wentz
    Department of Surgery, Indiana University School of Medicine, Indianapolis, USA
    J Surg Res 157:e87-95. 2009
    ..ICC etiologies involve chronic inflammation. We hypothesize that the nonsteroidal anti-inflammatory agent sulindac may prevent ICC by targeting cyclooxygenase-1 and -2 (COX-1, -2) as well as COX-independent pathways...
  95. ncbi request reprint A cellular Trojan Horse for delivery of therapeutic nanoparticles into tumors
    Mi Ran Choi
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Nano Lett 7:3759-65. 2007
    ..Here we report the demonstration of several key steps toward this therapeutic strategy: phagocytosis of Au nanoshells, and photoinduced cell death of monocytes/macrophages as isolates and within tumor spheroids...
  96. ncbi request reprint Apoptosis in spermatocytic and usual seminomas: a light microscopic and immunohistochemical study
    Elena F Bishop
    Department of Pathology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Mod Pathol 20:1036-44. 2007
    ..The variation in apoptosis of usual seminomas merits investigation as a prognostic parameter...