Research Topics
| James SkinnerSummaryAffiliation: Indiana University Country: USA Publications
Research Grants
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Detail Information
Publications
Reproducibility of maximal exercise test data in the HERITAGE family studyJ S Skinner
Indiana University, Bloomington, USA
Med Sci Sports Exerc 31:1623-8. 1999..The reproducibility of responses to maximal cycle ergometer testing was determined using data from the HERITAGE Family study at four Clinical Centers in the United States and Canada...- Chronic fatigue syndrome: matching exercise to symptom fluctuationsJames S Skinner
Department of Kinesiology, Indiana University, Bloomington, IN, 47405, USA
Phys Sportsmed 32:28-32. 2004..Even though a fair amount of variability exists in symptoms from one day to another, low- to moderate-intensity, intermittent exercise therapy appears to improve functional capacity and reduce fatigue and other symptoms... - Heart rate versus %VO2max: age, sex, race, initial fitness, and training response--HERITAGEJames S Skinner
Department of Kinesiology, Indiana University, Bloomington, IN, USA
Med Sci Sports Exerc 35:1908-13. 2003..Although we assumed that subjects were again working at the same %VO2max, there were no studies with a large heterogeneous population to determine whether this was correct... - Effects of different doses of physical activity on cardiorespiratory fitness among sedentary, overweight or obese postmenopausal women with elevated blood pressure: a randomized controlled trialTimothy S Church
Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge 70808 4124, USA
JAMA 297:2081-91. 2007..However, a poor understanding of the physical activity-fitness dose response relation remains... - G protein beta 3 polymorphism and hemodynamic and body composition phenotypes in the HERITAGE Family StudyTuomo Rankinen
Pennington Biomedical Research Center, Human Genomics Laboratory, Baton Rouge, Louisiana 70808 4124, USA
Physiol Genomics 8:151-7. 2002..The GNB3 genotype may play a minor role in HR and body fatness regulation in blacks and in responsiveness of resting BP to endurance training in black women... - The effects of exercise training on abdominal visceral fat, body composition, and indicators of the metabolic syndrome in postmenopausal women with and without estrogen replacement therapy: the HERITAGE family studyJohn S Green
Department of Health and Kinesiology, Texas A and M University, College Station, TX 77845, USA
Metabolism 53:1192-6. 2004..Also exercise training did not improve the overall MS status of either group, as LDL-C status improved in the ERT group while TG decreased in the NHRT group... - Effects of exercise training on glucose homeostasis: the HERITAGE Family StudyNormand G Boule
Division of Kinesiology, Laval University, Sainte Foy, Quebec, Canada
Diabetes Care 28:108-14. 2005..To determine the effect of a 20-week endurance training program in healthy, previously sedentary participants on measures derived from an intravenous glucose tolerance test (i.v.GTT)... - Hepatic lipase gene variant -514C>T is associated with lipoprotein and insulin sensitivity response to regular exercise: the HERITAGE Family StudyMargarita Teran-Garcia
Human Genomics Laboratory, Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
Diabetes 54:2251-5. 2005..The benefits from an exercise program on Si are likely to be substantial in the general population given the high frequency of the LIPC -514C allele, particularly in whites... - The TNF-alpha G-308A polymorphism is associated with C-reactive protein levels: the HERITAGE Family StudyHanna Maaria Lakka
Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, Louisiana 70808 4124, USA
Vascul Pharmacol 44:377-83. 2006..Pro-inflammatory cytokines, such as tumor necrosis factor alpha (TNF-alpha), stimulate the release of C-reactive protein (CRP). We investigated the association between the TNF-alpha G-308A polymorphism and plasma CRP levels... - Quantitative trait locus on chromosome 20q13 for plasma levels of C-reactive protein in healthy whites: the HERITAGE Family StudyTimo A Lakka
Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
Physiol Genomics 27:103-7. 2006..The present findings may be useful in the ongoing effort to search for genes contributing to inflammation and to identify individuals at an increased risk of chronic inflammatory diseases... - Effect of regular exercise on homocysteine concentrations: the HERITAGE Family StudyTomohiro Okura
Human Genomics Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
Eur J Appl Physiol 98:394-401. 2006..Men exhibit racial differences for tHcy responses to exercise training. Regular aerobic exercise has favorable effects on individuals with hyperhomocysteinemia, but tHcy slightly increased in individuals within the normal range... - Peroxisome proliferator-activated receptor-delta polymorphisms are associated with physical performance and plasma lipids: the HERITAGE Family StudyArto J Hautala
Pennington Biomedical Research Center, Human Genomics Laboratory, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808 4124, USA
Am J Physiol Heart Circ Physiol 292:H2498-505. 2007..DNA sequence variation in the PPARdelta locus is a potential modifier of changes in cardiorespiratory fitness and plasma HDL-C in healthy individuals in response to regular exercise... - CETP genotypes and HDL-cholesterol phenotypes in the HERITAGE Family StudyNadine Spielmann
Human Genomics Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana 70808 4124, USA
Physiol Genomics 31:25-31. 2007..The CETP and APOE genotypes account for up to 9% of the variance in HDL-c phenotypes in the HERITAGE Family Study... - Genome-wide linkage scan for submaximal exercise heart rate in the HERITAGE family studyNadine Spielmann
Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808 4124, USA
Am J Physiol Heart Circ Physiol 293:H3366-71. 2007..The most promising regions for fine mapping in the HERITAGE Family Study were found on 2q33 for HR50 training response in whites, on 10q25-26 for baseline HR60 in blacks, and on 18q21-22 for both baseline HR50 and DeltaHR60 in whites... - Effect of endothelin 1 genotype on blood pressure is dependent on physical activity or fitness levelsTuomo Rankinen
Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
Hypertension 50:1120-5. 2007..Our study provides an illustrative example of how physical activity and fitness level modifies the associations between a candidate gene and outcome phenotype... - Calcium intake is associated with adiposity in Black and White men and White women of the HERITAGE Family StudyRuth J F Loos
Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA
J Nutr 134:1772-8. 2004..04). No significant associations were found in Black women. Low Ca(2+) intake may be associated with higher adiposity, particularly in men and White women... 
Acetylcholinesterase/paraoxonase genotype and expression predict anxiety scores in Health, Risk Factors, Exercise Training, and Genetics studyElla H Sklan
Department of Biological Chemistry, Hebrew University of Jerusalem, Jerusalem 91904, Israel
Proc Natl Acad Sci U S A 101:5512-7. 2004....- A genetic study of cortisol measured before and after endurance training: the HERITAGE Family StudyMary F Feitosa
Division of Biostatistics, and Department of Genetics, Washington University School of Medicine, Saint Louis, MO 63110-1093, USA
Metabolism 51:360-5. 2002..The putative major gene effects appear to explain most of the observed familial resemblance, this will motivate further linkage and association studies... - Familial resemblance for plasma leptin: sample homogeneity across adiposity and ethnic groupsTreva Rice
Division of Biostatistics, Departments of Genetics, Washington University School of Medicine, St Louis, Missouri 63110 1093, USA
Obes Res 10:351-60. 2002..Therefore, the purpose of this study was to investigate heterogeneity hypotheses across ethnic groups and by adiposity level, using the same statistical methods... - Heritability of HR and BP response to exercise training in the HERITAGE Family StudyTreva Rice
Division of Biostatistics, Washington University School of Medicine, St Louis, MO 63110, USA
Med Sci Sports Exerc 34:972-9. 2002..The heritability of the response to exercise training in resting blood pressure (BP) and heart rate (HR) was assessed in 482 Caucasian individuals comprising 98 families participating in the HERITAGE Family Study... - Genome-wide linkage scan for exercise stroke volume and cardiac output in the HERITAGE Family StudyTuomo Rankinen
Pennington Biomedical Research Center, Human Genomics Laboratory, Baton Rouge, Louisiana 70808 4124, USA
Physiol Genomics 10:57-62. 2002..3, 3q13.3, 12q13.2) and one for baseline SV50 and Q50 (10p14). All these chromosomal regions include several potential candidate genes and therefore warrant further studies in the HERITAGE cohort and other studies... - Role of ghrelin polymorphisms in obesity based on three different studiesOlavi Ukkola
Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808 4124, USA
Obes Res 10:782-91. 2002..Associations between preproghrelin DNA variants and obesity-related phenotypes were studied in 3004 subjects from the Québec Family Study (QFS), the HERITAGE Family Study (HERITAGE), and the Swedish Obese Subjects (SOS) Study... - Major gene effects on exercise ventilatory threshold: the HERITAGE Family StudyMary F Feitosa
Division of Biostatistics, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
J Appl Physiol 93:1000-6. 2002.... - Lack of pleiotropic genetic effects between adiposity and sex hormone-binding globulin concentrations before and after 20 weeks of exercise training: the HERITAGE family studyMary F Feitosa
Division of Biostatistics, Department of Genetics, Washington University School of Medicine, St Louis, MO 63110-1093, USA
Metabolism 52:35-41. 2003.... - Uncoupling protein 3 gene is associated with body composition changes with training in HERITAGE studyChristian Marc Lanouette
Hôpital Laval and Kinesiology, Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Sainte Foy, Quebec, Canada G1K 7P4
J Appl Physiol 92:1111-8. 2002..0006), with a borderline result for body mass index (P = 0.06). We concluded that UCP3 could be involved in body composition changes after regular exercise... - Association of apolipoprotein E polymorphism with blood lipids and maximal oxygen uptake in the sedentary state and after exercise training in the HERITAGE family studyArthur S Leon
Laboratory of Physiological Hygiene and Exercise Science, Division of Kinesiology, University of Minnesota, Minneapolis 55455, USA
Metabolism 53:108-16. 2004..Apo E polymorphism was not found to be associated with Vo(2max) levels either in the sedentary state nor the Vo(2max) response to exercise training, contrary to previous reports... - Dose Response to Exercise in Women aged 45-75 yr (DREW): design and rationaleGina M Morss
Centers for Integrated Health Research, The Cooper Institute, 12330 Preston Road, Dallas, TX 75230, USA
Med Sci Sports Exerc 36:336-44. 2004.... - Menopause, estrogen, and training effects on exercise hemodynamics: the HERITAGE studyJohn S Green
Department of Health and Kinesiology, Texas A and M University, College Station, TX 77843 4243, USA
Med Sci Sports Exerc 34:74-82. 2002..To investigate the influences of menopause, hormone replacement, and endurance exercise training on cardiovascular hemodynamics and oxygen uptake parameters during exercise in women... - Fitness alters the associations of BMI and waist circumference with total and abdominal fatIan Janssen
Department of Community Health and Epidemiology, Division of Endocrinology and Metabolism, Queen's University, Kingston, Ontario, Canada
Obes Res 12:525-37. 2004..DISCUSSION: These findings suggest that a reduction in total adiposity and abdominal fat may be a means by which CRF attenuates the health risk attributable to obesity as determined by BMI and WC...
Research Grants
- HERITAGE--GENETICS, RESPONSE TO EXERCISE, RISK FACTORSJames Skinner; Fiscal Year: 1999..This research should increase out understanding of human variation, the genetics of adaptation to exercise- training and of the concomitant changes in cardiovascular disease and diabetes risk factors. ..