Research Topics
Species | J R SimonSummaryAffiliation: Indiana University Country: USA Publications
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Publications
A possible role for tyrosine kinases in the regulation of the neuronal dopamine transporter in mouse striatumJ R Simon
Department of Psychiatry, Indiana University School of Medicine, Indianapolis 46202, USA
Neurosci Lett 224:201-5. 1997..It is suggested that protein tyrosine kinases play a role in the cascade of events which ultimately lead to regulation of neuronal dopamine transport...- Atrophy and loss of dopaminergic mesencephalic neurons in heterozygous weaver miceT Verina
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis 46202 5120, USA
Exp Brain Res 113:5-12. 1997..Our findings imply that a single dose of the weaver gene in the mouse is associated with cellular damage leading to a chronic deficiency in the mesostriatal dopaminergic system... - Age-dependent alterations in dopamine content, tyrosine hydroxylase activity, and dopamine uptake in the striatum of the weaver mutant mouseJ R Simon
Department of Psychiatry, Indiana University School of Medicine, Indianapolis 46202 4887
J Neurochem 62:543-8. 1994.... - Endogenous serotonin release from the dopamine-deficient striatum of the weaver mutant mouseE H Stotz-Potter
Department of Psychiatry Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis 46202 4887, USA
Neurochem Res 20:821-6. 1995.... - Studies on the striatal dopamine uptake system of weaver mutant mice and effects of ventral mesencephalic graftsL C Triarhou
Department of Pathology and Laboratory Medicine Laboratory of Cellular and Molecular Neuropathology, Indiana University School of Medicine, Indianapolis 46202
Neurochem Res 19:1349-58. 1994..The parallel measurements of motor performance and DA uptake in the same animals offers an index of behavioral recovery as a function of transmitter-related activity.(ABSTRACT TRUNCATED AT 400 WORDS).. - Is there a significant somatodendritic uptake of dopamine in the substantia nigra? Evidence from the weaver mutant mouseJ R Simon
Department of Psychiatry, Indiana University School of Medicine, Indianapolis 46202 4887
Neurochem Int 22:471-7. 1993..Under such experimental conditions, it is likely that a large proportion of the released tritium might come from neurons other than those which contain endogenous neurotransmitter dopamine... - Topographic distribution of dopamine uptake, choline uptake, choline acetyltransferase, and GABA uptake in the striata of weaver mutant miceJ R Simon
Department of Psychiatry, Indiana University School of Medicine, Indianapolis 46202
Neurochem Res 17:431-6. 1992..The results also indicate that the striatal cholinergic and GABAergic interneurons are not directly or indirectly affected by the weaver gene... - The weaver mutant mouse as a model of nigrostriatal dysfunctionJ R Simon
Department of Psychiatry, Indiana University School of Medicine, Indianapolis
Mol Neurobiol 9:183-9. 1994..Thus, the weaver mouse provides a unique animal model for studying naturally induced neuronal degeneration that complements those models using surgical and pharmacological protocols... - Dorsomedial hypothalamic GABA dysfunction produces physiological arousal following sodium lactate infusionsA Shekhar
Department of Psychiatry, Indiana University Medical Center, Indianapolis 46202, USA
Pharmacol Biochem Behav 55:249-56. 1996..These results indicate that chronic reduction of GABA function in the DMH leads to the development of panic-like disorder in this animal model... - Comparison of alterations in tyrosine hydroxylase, dopamine levels, and dopamine uptake in the striatum of the weaver mutant mouseJ A Richter
Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis 46202
Neurochem Res 17:437-41. 1992..This lower affinity for substrate suggests that the TH enzyme itself may be altered in the nigro-striatal system of the weaver mutant mouse...