J R Simon

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. ncbi request reprint Is there a significant somatodendritic uptake of dopamine in the substantia nigra? Evidence from the weaver mutant mouse
    J R Simon
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis 46202 4887
    Neurochem Int 22:471-7. 1993
  2. ncbi request reprint A possible role for tyrosine kinases in the regulation of the neuronal dopamine transporter in mouse striatum
    J R Simon
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis 46202, USA
    Neurosci Lett 224:201-5. 1997
  3. ncbi request reprint Atrophy and loss of dopaminergic mesencephalic neurons in heterozygous weaver mice
    T Verina
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis 46202 5120, USA
    Exp Brain Res 113:5-12. 1997
  4. ncbi request reprint Age-dependent alterations in dopamine content, tyrosine hydroxylase activity, and dopamine uptake in the striatum of the weaver mutant mouse
    J R Simon
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis 46202 4887
    J Neurochem 62:543-8. 1994
  5. ncbi request reprint Endogenous serotonin release from the dopamine-deficient striatum of the weaver mutant mouse
    E H Stotz-Potter
    Department of Psychiatry Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis 46202 4887, USA
    Neurochem Res 20:821-6. 1995
  6. ncbi request reprint Studies on the striatal dopamine uptake system of weaver mutant mice and effects of ventral mesencephalic grafts
    L C Triarhou
    Department of Pathology and Laboratory Medicine Laboratory of Cellular and Molecular Neuropathology, Indiana University School of Medicine, Indianapolis 46202
    Neurochem Res 19:1349-58. 1994
  7. ncbi request reprint Topographic distribution of dopamine uptake, choline uptake, choline acetyltransferase, and GABA uptake in the striata of weaver mutant mice
    J R Simon
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis 46202
    Neurochem Res 17:431-6. 1992
  8. ncbi request reprint The weaver mutant mouse as a model of nigrostriatal dysfunction
    J R Simon
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis
    Mol Neurobiol 9:183-9. 1994
  9. ncbi request reprint Dorsomedial hypothalamic GABA dysfunction produces physiological arousal following sodium lactate infusions
    A Shekhar
    Department of Psychiatry, Indiana University Medical Center, Indianapolis 46202, USA
    Pharmacol Biochem Behav 55:249-56. 1996
  10. ncbi request reprint Comparison of alterations in tyrosine hydroxylase, dopamine levels, and dopamine uptake in the striatum of the weaver mutant mouse
    J A Richter
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis 46202
    Neurochem Res 17:437-41. 1992

Collaborators

  • B Ghetti
  • J Norton
  • L C Triarhou
  • T Verina
  • A Shekhar
  • J A Richter
  • E H Stotz-Potter
  • D Laferty
  • J J Sorbel
  • S R Keim
  • E H Stotz
  • W J McBride
  • J M Palacios
  • B Landwehrmeyer
  • W C Low

Detail Information

Publications10

  1. ncbi request reprint Is there a significant somatodendritic uptake of dopamine in the substantia nigra? Evidence from the weaver mutant mouse
    J R Simon
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis 46202 4887
    Neurochem Int 22:471-7. 1993
    ..Under such experimental conditions, it is likely that a large proportion of the released tritium might come from neurons other than those which contain endogenous neurotransmitter dopamine...
  2. ncbi request reprint A possible role for tyrosine kinases in the regulation of the neuronal dopamine transporter in mouse striatum
    J R Simon
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis 46202, USA
    Neurosci Lett 224:201-5. 1997
    ..It is suggested that protein tyrosine kinases play a role in the cascade of events which ultimately lead to regulation of neuronal dopamine transport...
  3. ncbi request reprint Atrophy and loss of dopaminergic mesencephalic neurons in heterozygous weaver mice
    T Verina
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis 46202 5120, USA
    Exp Brain Res 113:5-12. 1997
    ..Our findings imply that a single dose of the weaver gene in the mouse is associated with cellular damage leading to a chronic deficiency in the mesostriatal dopaminergic system...
  4. ncbi request reprint Age-dependent alterations in dopamine content, tyrosine hydroxylase activity, and dopamine uptake in the striatum of the weaver mutant mouse
    J R Simon
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis 46202 4887
    J Neurochem 62:543-8. 1994
    ....
  5. ncbi request reprint Endogenous serotonin release from the dopamine-deficient striatum of the weaver mutant mouse
    E H Stotz-Potter
    Department of Psychiatry Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis 46202 4887, USA
    Neurochem Res 20:821-6. 1995
    ....
  6. ncbi request reprint Studies on the striatal dopamine uptake system of weaver mutant mice and effects of ventral mesencephalic grafts
    L C Triarhou
    Department of Pathology and Laboratory Medicine Laboratory of Cellular and Molecular Neuropathology, Indiana University School of Medicine, Indianapolis 46202
    Neurochem Res 19:1349-58. 1994
    ..The parallel measurements of motor performance and DA uptake in the same animals offers an index of behavioral recovery as a function of transmitter-related activity.(ABSTRACT TRUNCATED AT 400 WORDS)..
  7. ncbi request reprint Topographic distribution of dopamine uptake, choline uptake, choline acetyltransferase, and GABA uptake in the striata of weaver mutant mice
    J R Simon
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis 46202
    Neurochem Res 17:431-6. 1992
    ..The results also indicate that the striatal cholinergic and GABAergic interneurons are not directly or indirectly affected by the weaver gene...
  8. ncbi request reprint The weaver mutant mouse as a model of nigrostriatal dysfunction
    J R Simon
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis
    Mol Neurobiol 9:183-9. 1994
    ..Thus, the weaver mouse provides a unique animal model for studying naturally induced neuronal degeneration that complements those models using surgical and pharmacological protocols...
  9. ncbi request reprint Dorsomedial hypothalamic GABA dysfunction produces physiological arousal following sodium lactate infusions
    A Shekhar
    Department of Psychiatry, Indiana University Medical Center, Indianapolis 46202, USA
    Pharmacol Biochem Behav 55:249-56. 1996
    ..These results indicate that chronic reduction of GABA function in the DMH leads to the development of panic-like disorder in this animal model...
  10. ncbi request reprint Comparison of alterations in tyrosine hydroxylase, dopamine levels, and dopamine uptake in the striatum of the weaver mutant mouse
    J A Richter
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis 46202
    Neurochem Res 17:437-41. 1992
    ..This lower affinity for substrate suggests that the TH enzyme itself may be altered in the nigro-striatal system of the weaver mutant mouse...