Research Topics
| CHRISTIAN MAXIMILLIAN SCHMIDTSummaryAffiliation: Indiana University Country: USA Publications
Research Grants
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Detail Information
Publications
Preoperative predictors of malignancy in pancreatic intraductal papillary mucinous neoplasmsChad A Wiesenauer
Department of Surgery, Indiana University School of Medicine, USA
Arch Surg 138:610-7; discussion 617-8. 2003..Malignant intraductal papillary mucinous neoplasms (IPMNs) can be predicted before surgery...- Novel combination of cyclooxygenase-2 and MEK inhibitors in human hepatocellular carcinoma provides a synergistic increase in apoptosisC Max Schmidt
Department of Surgery and The Indiana University Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
J Gastrointest Surg 7:1024-33. 2003..This novel combination may be useful for in vivo studies of hepatocellular carcinoma... - PGE(2) in pancreatic cyst fluid helps differentiate IPMN from MCN and predict IPMN dysplasiaC Max Schmidt
Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
J Gastrointest Surg 12:243-9. 2008..PGE(2) level may also be an indicator of malignant progression of IPMN before ductal obstruction by tumor. Prospective evaluation will be necessary to evaluate the clinical role of PGE(2) level in pancreatic fluid... 
Long-term effects on diet after proctocolectomy for ulcerative colitisC Max Schmidt
Department of Surgery, Indiana University School of Medicine, 1044 W Walnut St, R4 039, Indianapolis, IN 46202, USA
Am J Surg 195:353-7; discussion 357. 2008..Patients with ulcerative colitis (UC) often report dietary intolerances. Our aim was to assess the effects of proctocolectomy (PC) for UC on dietary intolerances...
Role of 14-3-3σ in poor prognosis and in radiation and drug resistance of human pancreatic cancersZhaomin Li
Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
BMC Cancer 10:598. 2010..Recently, the level of 14-3-3σ mRNA was found to be increased in pancreatic cancers and this increased expression may contribute to the failure in treatment of pancreatic cancers. In the present study, we tested this hypothesis...- Total pancreatectomy (R0 resection) improves survival over subtotal pancreatectomy in isolated neck margin positive pancreatic adenocarcinomaC Max Schmidt
Department of Surgery and Indiana University Cancer Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Surgery 142:572-8; discussion 578-80. 2007..In patients undergoing pancreaticoduodenectomy (PD) for pancreatic adenocarcinoma (PC), conversion to total pancreatectomy (TP) may be necessary to achieve R0 resection... - Intraductal papillary mucinous neoplasms: predictors of malignant and invasive pathologyC Max Schmidt
Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Ann Surg 246:644-51; discussion 651-4. 2007..Determine whether size and other preoperative parameters predict malignant or invasive intraductal papillary mucinous neoplasia (IPMN)... - Evaluation and management of incidental thyroid nodules in patients with another primary malignancyScott M Wilhelm
Department of Surgery, University Hospitals Case Medical Center, Cleveland, Ohio 44106, USA
Surgery 142:581-6; discussion 586-7. 2007..We sought to determine the rate of malignancy in incidental thyroid nodules in patients with other malignancies, and examine the accuracy of ultrasound (US) versus computed tomography (CT) in determining nodule size... - Pancreatic fistula following pancreaticoduodenectomy: clinical predictors and patient outcomesC Max Schmidt
Department of Surgery, School of Medicine, Indiana University, Indianapolis, IN 46202, USA
HPB Surg 2009:404520. 2009..Outcomes in patients with PF are remarkable for a higher rate of septic complications, longer hospital stays, but in this study, no increased mortality... - Introduction: SSAT/AGA/ASGE State-of-the-Art Conference: necrotizing pancreatitis: novel minimally invasive strategiesC Max Schmidt
Department of Surgery, Indiana University School of Medicine, 980 W Walnut St C522, Indianapolis, IN 46202, USA
J Gastrointest Surg 15:1086-8. 2011..e., "who, when, and how") of necrotizing pancreatitis is an ongoing source of considerable controversy. Novel minimally invasive strategies are being increasingly employed to perform pancreatic necrosectomy... - Pancreaticoduodenectomy: a 20-year experience in 516 patientsC Max Schmidt
Department of Surgery, University Hospital, Indiana University School of Medicine, Indianapolis, USA
Arch Surg 139:718-25; discussion 725-7. 2004..Pancreaticoduodenectomy (PD) is a safe procedure for a variety of periampullary conditions... - MEK inhibition of pancreatic carcinoma cells by U0126 and its effect in combination with sulindacMichele T Yip-Schneider
Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA
Pancreas 27:337-44. 2003..In addition, we investigated whether the MEK-ERK pathway influenced the response of pancreatic cancer cells to nonsteroidal antiinflammatory drugs (NSAIDs)... - Effect of hospital volume, surgeon experience, and surgeon volume on patient outcomes after pancreaticoduodenectomy: a single-institution experienceC Max Schmidt
Department of Surgery, Indiana University School of Medicine, 980 W Walnut Street, Indianapolis, IN 46202, USA
Arch Surg 145:634-40. 2010..To determine the importance of hospital volume, surgeon experience, and surgeon volume in performing pancreaticoduodenectomy (PD)... - Multiple anticancer effects of blocking MEK-ERK signaling in hepatocellular carcinomaChad A Wiesenauer
Department of Surgery, Indianapolis, IN 46202, USA
J Am Coll Surg 198:410-21. 2004.... - The effect of doxorubicin on MEK-ERK signaling predicts its efficacy in HCCJennifer Choi
Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
J Surg Res 150:219-26. 2008..Hepatocellular cancer (HCC) is a leading cause of cancer-related death worldwide. Historically, doxorubicin (DOX) has been widely used against unresectable HCC with variable response rates... - Resistance to mitogen-activated protein kinase kinase (MEK) inhibitors correlates with up-regulation of the MEK/extracellular signal-regulated kinase pathway in hepatocellular carcinoma cellsMichele T Yip-Schneider
Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
J Pharmacol Exp Ther 329:1063-70. 2009..Our findings also provide preclinical evidence suggesting that the status of the MEK/ERK pathway in patients may predict response to MEK/ERK-targeted therapeutics... - Parthenolide cooperates with NS398 to inhibit growth of human hepatocellular carcinoma cells through effects on apoptosis and G0-G1 cell cycle arrestMatthew C Ralstin
Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Mol Cancer Res 4:387-99. 2006..Our results suggest that parthenolide may be effective in combination with COX-2 inhibitors for the treatment of hepatocellular carcinoma... - Pancreatic cancer cell genetics and signaling response to treatment correlate with efficacy of gemcitabine-based molecular targeting strategiesBryan Holcomb
Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
J Gastrointest Surg 12:288-96. 2008..We hypothesize that pancreatic cancer cell genetics and signaling response to treatment correlate with efficacy of gemcitabine-based molecular targeting strategies... - Ethanol-TGFalpha-MEK signaling promotes growth of human hepatocellular carcinomaMatthew Hennig
Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA
J Surg Res 154:187-95. 2009..The effects of ethanol on extracellular signal-regulated kinase (ERK) activation, transforming growth factor alpha (TGF-alpha), and HCC growth were examined in this study... - Sulindac prevents carcinogen-induced intrahepatic cholangiocarcinoma formation in vivoSabrina C Wentz
Department of Surgery, Indiana University School of Medicine, Indianapolis, USA
J Surg Res 157:e87-95. 2009..ICC etiologies involve chronic inflammation. We hypothesize that the nonsteroidal anti-inflammatory agent sulindac may prevent ICC by targeting cyclooxygenase-1 and -2 (COX-1, -2) as well as COX-independent pathways... - Effect of celecoxib and novel agent LC-1 in a hamster model of lung cancerReid C Vegeler
Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
J Surg Res 143:169-76. 2007..The therapeutic potential of celecoxib, a COX-2 selective inhibitor, and LC-1, a pro-apoptotic drug with accompanying inhibition of NF-kappaB, were investigated... - Cyclooxygenase-2 expression in hamster and human pancreatic neoplasiaPamela L Crowell
Indiana University Cancer Center, Indiana University School of Medicine, Indianapolis, IN, USA
Neoplasia 8:437-45. 2006..The BOP-induced hamster carcinogenesis model is a representative model used to study the role of COX-2 in well-differentiated pancreatic tumorigenesis. COX inhibitors may have a role in preventing tumor engraftment/formation... - A multicenter analysis of distal pancreatectomy for adenocarcinoma: is laparoscopic resection appropriate?David A Kooby
Department of Surgery, Emory University School of Medicine, Atlanta, GA 30322, USA
J Am Coll Surg 210:779-85, 786-7. 2010..As compared with open distal pancreatectomy (ODP), laparoscopic distal pancreatectomy (LDP) affords improved perioperative outcomes. The role of LDP for patients with pancreatic ductal adenocarcinoma (PDAC) is not defined... - Pancreatic acinar cell carcinoma: a multi-institutional studyJesus M Matos
Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
J Gastrointest Surg 13:1495-502. 2009..This study combines the experience with ACC from multiple academic institutions to better understand its natural history and outcomes... - CT vs MRCP: optimal classification of IPMN type and extentJoshua A Waters
Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
J Gastrointest Surg 12:101-9. 2008..CT scanning commonly serves as the primary imaging modality before surgery. We hypothesized MRCP provides better characterization of IPMN type/extent, which more closely matches actual pathology... - Differential sensitivity of chemoresistant neuroblastoma subtypes to MAPK-targeted treatment correlates with ERK, p53 expression, and signaling response to U0126Andrew C Eppstein
Department of Surgery, Indiana University School of Medicine and Riley Children's Hospital, Indianapolis, IN 46202, USA
J Pediatr Surg 41:252-9. 2006..Although MEK inhibition holds promise in targeting I-type NB cells, successfully treating this heterogeneous tumor may require combining agents against N- and S-type cells... - Does type of pancreaticojejunostomy after pancreaticoduodenectomy decrease rate of pancreatic fistula? A randomized, prospective, dual-institution trialAdam C Berger
Department of Surgery, Thomas Jefferson University, Jefferson Pancreas, Biliary and Related Cancer Center, Philadelphia, PA 19107, USA
J Am Coll Surg 208:738-47; discussion 747-9. 2009..We tested the hypothesis that a duct to mucosa pancreaticojejunostomy would reduce the PF rate... - Adjuvant chemoradiation therapy for pancreatic adenocarcinoma: who really benefits?Nipun B Merchant
Department of Surgery, Vanderbilt University Medical Center, Nashville, TN 37232 6860, USA
J Am Coll Surg 208:829-38; discussion 838-41. 2009..The primary aim of this study was to determine if CRT improved survival in patients with resected pancreatic cancer in a large, multiinstitutional cohort of patients... - Parthenolide and sulindac cooperate to mediate growth suppression and inhibit the nuclear factor-kappa B pathway in pancreatic carcinoma cellsMichele T Yip-Schneider
Department of Surgery, Indiana University School of Medicine, Room 041, Building R4, 1044 West Walnut Street, Indianapolis, IN 46202, USA
Mol Cancer Ther 4:587-94. 2005..These data provide preclinical support for a combined chemotherapeutic approach with NF-kappa B inhibitors and NSAIDs for the treatment of pancreatic adenocarcinoma... - Analysis of Ki-67 antigen expression, DNA proliferative fraction, and survival in resected cancer of the pancreasKatie J Stanton
Department of Surgery, Indiana University School of Medicine, and Roudebush VA Medical Center, 545 Barnhill Drive, EM 244, Indianapolis, IN 46202, USA
Am J Surg 186:486-92. 2003.... - Inhibition of the phosphatidylinositol 3'-kinase signaling pathway increases the responsiveness of pancreatic carcinoma cells to sulindacMichele T Yip-Schneider
Departments of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
J Gastrointest Surg 7:354-63. 2003..Taken together, our results suggest that inhibition of the PI3K/Akt signaling pathway may sensitize pancreatic tumor cells to therapy with NSAIDs such as sulindac... - Comparison of computational algorithms for the classification of liver cancer using SELDI mass spectrometry: a case studyChangyu Shen
Division of Biostatistics, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Cancer Inform 3:329-39. 2007..In this report, we describe a comparative case study on the classification accuracy of hepatocellular carcinoma based on the serum proteomic pattern generated from a Surface Enhanced Laser Desorption/Ionization (SELDI) mass spectrometer... - The effects of a novel MEK inhibitor PD184161 on MEK-ERK signaling and growth in human liver cancerPatrick J Klein
Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
Neoplasia 8:1-8. 2006..Thus, we speculate that the degree of success of MEK targeted treatment in HCC and other cancers may, in part, depend on the discovery of mechanisms governing MEK inhibitor signaling resistance... - Intraductal papillary mucinous neoplasm--when to resect?Joshua A Waters
Department of Surgery, Indiana University School of Medicine, 1044 West Walnut Street, Room R4 039, Indianapolis, IN 46202, USA
Adv Surg 42:87-108. 2008.... - Acinar cell carcinoma of the pancreas in the United States: prognostic factors and comparison to ductal adenocarcinomaC Max Schmidt
Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
J Gastrointest Surg 12:2078-86. 2008..Pancreatic acinar cell carcinoma (ACC) is a rare tumor with poorly defined prognosis... - Effect of celecoxib and the novel anti-cancer agent, dimethylamino-parthenolide, in a developmental model of pancreatic cancerMichele T Yip-Schneider
Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
Pancreas 37:e45-53. 2008..The efficacy of a novel bioavailable anticancer agent, dimethylamino-parthenolide (DMAPT), and the cyclooxygenase 2 inhibitor, celecoxib, was evaluated in a carcinogen-induced developmental model of pancreatic cancer... - Targeting MEK is effective chemoprevention of hepatocellular carcinoma in TGF-alpha-transgenic miceSabrina C Wentz
Department of Surgery, Indiana University School of Medicine, 1044 W Walnut St R4 039, Indianapolis, IN 46202, USA
J Gastrointest Surg 12:30-7. 2008..Control and treated HCC demonstrated similar proliferation rates, but apoptosis appeared increased with treatment. MEK targeting is effective HCC chemoprevention, perhaps by lowering the apoptotic threshold... - Suppression of pancreatic tumor growth by combination chemotherapy with sulindac and LC-1 is associated with cyclin D1 inhibition in vivoMichele T Yip-Schneider
Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Mol Cancer Ther 6:1736-44. 2007..These results suggest that LC-1 and sulindac may mediate their antitumor effects, in part, by altering cyclin D1 levels. Furthermore, this study provides preclinical evidence for the therapeutic efficacy of these agents... - A margin-negative R0 resection accomplished with minimal postoperative complications is the surgeon's contribution to long-term survival in pancreatic cancerThomas J Howard
Pancreas Research Group, Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
J Gastrointest Surg 10:1338-45; discussion 1345-6. 2006..Long-term survival in patients with pancreatic cancer after resection remains poor. Achieving a margin negative resection (R0) with no postoperative complications are prognostic variables that can be affected by the surgeon... - Role of endoscopic ultrasound in the diagnosis of intraductal papillary mucinous neoplasms: correlation with surgical histopathologyShireen A Pais
Department of Gastroenterology and Hepatology, Indiana University Medical Center, Indianapolis, Indiana, USA
Clin Gastroenterol Hepatol 5:489-95. 2007..The purpose of this study was to evaluate the role of endoscopic ultrasound (EUS) in differentiating benign and malignant IPMNs... - Fatty pancreas: a factor in postoperative pancreatic fistulaAbhishek Mathur
Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Ann Surg 246:1058-64. 2007..To determine whether patients who develop a pancreatic fistula after pancreatoduodenectomy are more likely to have pancreatic fat than matched controls... - Solid pseudopapillary neoplasms of the pancreas: a multi-institutional study of 21 patientsJesus M Matos
Department of Surgery, Indiana University School of Medicine, Indianapolis, 46202, USA
J Surg Res 157:e137-42. 2009..The goal of this study was to better understand the nature of these rare tumors through analysis of patients' clinical presentations and outcomes following surgical resection... - Mucin secreting cystic lesions of the pancreas: treatment by enucleationJames A Madura
Department of Surgery, The Indiana University Medical Center, Indianapolis, Indiana, USA
Am Surg 70:106-12; discussion 113. 2004..A review of benign tumors reported to have been treated by cyst enucleation in the literature confirms the rationale of this approach in highly selected lesions... - The role of nuclear factor kappaB in pancreatic cancer and the clinical applications of targeted therapyBryan Holcomb
Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Pancreas 36:225-35. 2008..This review explores the roles of NF-JB in these processes and examines the evidence that different NF-kappaB-inhibiting drugs can improve the treatment of pancreatic cancer... - A pilot study of perillyl alcohol in pancreatic cancerJesus M Matos
Department of Surgery, Indiana University School of Medicine at Indiana University Purdue University at Indianapolis, Indianapolis, Indiana, USA
J Surg Res 147:194-9. 2008..Measurement of cell-specific biological endpoints may clarify the evaluation of a newer generation of compounds. Perillyl alcohol has shown chemotherapeutic activity in preclinical systems through enhancing apoptosis... - A pilot study of proteomic profiles of human hepatocellular carcinoma in the United StatesJesus M Matos
Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA
J Surg Res 155:237-43. 2009..Validation and further investigation of these protein changes may lead to the discovery of new molecular targets for therapy, biomarkers for early detection, and new endpoints for therapeutic efficacy and toxicity... - Robotic distal pancreatectomy: cost effective?Joshua A Waters
Department of Surgery, Indiana University, Indianapolis, IN 46202, USA
Surgery 148:814-23. 2010..This study compares the costs and the outcomes of open, laparoscopic, and robotic distal pancreatectomies. We hypothesized that robotic distal pancreatectomy is cost-effective... - Targeting mitogen-activated protein kinase kinase with the inhibitor PD0325901 decreases hepatocellular carcinoma growth in vitro and in mouse model systemsMatthew Hennig
Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
Hepatology 51:1218-25. 2010..These studies provide compelling preclinical evidence that targeting MEK in human clinical trials may be promising for the treatment of HCC... - Prepancreatic portal vein in a patient with intestinal nonrotation: report of a caseMatthew Ziegler
Department of Surgery, Indiana University, 545 Barnhill Drive EH 202, Indianapolis, IN 46202, USA
J Gastrointest Surg 14:729-31. 2010..This anomaly was identified prior to surgery on CT scan of the abdomen... - Demographic and clinical factors related to ostomy complications and quality of life in veterans with an ostomyJoyce Pittman
School of Nursing, Indiana University Purdue University at Indianapolis, Indianapolis, Indiana, USA
J Wound Ostomy Continence Nurs 35:493-503. 2008..The purpose of this study is to describe demographic, clinical, and quality-of-life variables related to ostomy complications (skin irritation, leakage, and difficulty adjusting to an ostomy) in a veteran population in the United States... - Pancreatic necrosectomy: North American mortality is much lower than expectedPurvi Y Parikh
Department of Surgery, Indiana University, Indianapolis, IN, USA
J Am Coll Surg 209:712-9. 2009..But no national data have been available for patients with necrotizing pancreatitis. In 2007, a CPT code specific for debridement of pancreatic necrosis became available... - Comorbidities play a larger role in predicting health-related quality of life compared to having an ostomySushma Jain
Center for Surgical Outcomes and Quality, Department of Surgery, David Geffen School of Medicine at UCLA, 10833 Le Conte Ave, Los Angeles, CA 90095, USA
Am J Surg 194:774-9; discussion 779. 2007..Previous research suggests an ostomy worsens health-related quality of life (HR-QOL), but comorbidities also can affect HR-QOL... - Cryoablation of unresectable pancreatic cancerStephen J Kovach
Department of Surgery, University of Rochester Medical Center, Box SURG, 601 Elmwood Avenue, Rochester, NY 14642, USA
Surgery 131:463-4. 2002..Future studies to determine its therapeutic role in the management of unresectable pancreatic cancer are indicated... - Pancreatic surgery: evolution at a high-volume centerKathryn M Ziegler
Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Surgery 148:702-9; discussion 709-10. 2010..Therefore, the aims of this report are to determine whether the pancreatic operations or the spectrum of disease have evolved at a high-volume center... - Demographic, clinical, and quality of life variables related to embarrassment in veterans living with an intestinal stomaKimberly A Mitchell
School of Nursing, Indiana University Purdue University at Indianapolis, Indianapolis, Indiana, USA
J Wound Ostomy Continence Nurs 34:524-32. 2007..The study aims were to identify demographic, clinical, and quality of life variables related to embarrassment for people living with ostomies and to determine the experiences and/or feelings of veterans who were embarrassed by their ostomy...
Research Grants
- Biomarkers of COX-2 inhibitors in intraductal papillary mucinous neoplasm (IPMN)Christian Schmidt; Fiscal Year: 2007....