Andrew Saykin

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. pmc Analysis of copy number variation in Alzheimer's disease: the NIALOAD/ NCRAD Family Study
    Shanker Swaminathan
    Department of Radiology and Imaging Sciences, Center for Neuroimaging, Indiana University School of Medicine, Indianapolis, IN, USA
    Curr Alzheimer Res 9:801-14. 2012
  2. pmc Amyloid pathway-based candidate gene analysis of [(11)C]PiB-PET in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort
    Shanker Swaminathan
    Department of Radiology and Imaging Sciences, Center for Neuroimaging, Indiana University School of Medicine, Indianapolis, IN, USA
    Brain Imaging Behav 6:1-15. 2012
  3. pmc Alzheimer's Disease Neuroimaging Initiative biomarkers as quantitative phenotypes: Genetics core aims, progress, and plans
    Andrew J Saykin
    Department of Radiology and Imaging Sciences, Center for Neuroimaging, Indiana University School of Medicine, Indianapolis, IN, USA
    Alzheimers Dement 6:265-73. 2010
  4. pmc Baseline MRI predictors of conversion from MCI to probable AD in the ADNI cohort
    Shannon L Risacher
    IU Center for Neuroimaging, Division of Imaging Sciences, Department of Radiology, Indiana University School of Medicine, 950 W Walnut St, R2 E124, Indianapolis, IN 46202, USA
    Curr Alzheimer Res 6:347-61. 2009
  5. pmc Structural and functional magnetic resonance imaging of autism spectrum disorders
    Kimberly A Stigler
    Christian Sarkine Autism Treatment Center, James Whitcomb Riley Hospital for Children, Indianapolis, IN 46202 5200, USA
    Brain Res 1380:146-61. 2011
  6. pmc Sparse bayesian learning for identifying imaging biomarkers in AD prediction
    Li Shen
    Center for Neuroimaging, Department of Radiology and Imaging Sciences, USA
    Med Image Comput Comput Assist Interv 13:611-8. 2010
  7. pmc Regional reproducibility of pulsed arterial spin labeling perfusion imaging at 3T
    Yang Wang
    IU Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Neuroimage 54:1188-95. 2011
  8. pmc Gray matter reduction associated with systemic chemotherapy for breast cancer: a prospective MRI study
    Brenna C McDonald
    Center for Neuroimaging, Department of Radiology and Imaging Sciences and the Melvin and Bren Simon Cancer Center, Indiana University School of Medicine, 950 W Walnut St, R2 E124, Indianapolis, IN 46202, USA
    Breast Cancer Res Treat 123:819-28. 2010
  9. pmc Comparison of manual and automated determination of hippocampal volumes in MCI and early AD
    Li Shen
    IU Center for Neuroimaging, Div of Imaging Sciences, Dept of Radiology, Indiana University School of Medicine, 950 W Walnut St, R2 E124, Indianapolis, IN 46202, USA
    Brain Imaging Behav 4:86-95. 2010
  10. doi request reprint In-home virtual reality videogame telerehabilitation in adolescents with hemiplegic cerebral palsy
    Meredith R Golomb
    Division of Pediatric Neurology, Indiana University School of Medicine, Indianapolis, IN, USA
    Arch Phys Med Rehabil 91:1-8.e1. 2010

Detail Information

Publications16

  1. pmc Analysis of copy number variation in Alzheimer's disease: the NIALOAD/ NCRAD Family Study
    Shanker Swaminathan
    Department of Radiology and Imaging Sciences, Center for Neuroimaging, Indiana University School of Medicine, Indianapolis, IN, USA
    Curr Alzheimer Res 9:801-14. 2012
    ..Replication in independent samples as well as further analyses of these gene regions is warranted...
  2. pmc Amyloid pathway-based candidate gene analysis of [(11)C]PiB-PET in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort
    Shanker Swaminathan
    Department of Radiology and Imaging Sciences, Center for Neuroimaging, Indiana University School of Medicine, Indianapolis, IN, USA
    Brain Imaging Behav 6:1-15. 2012
    ..Pathway-based genetic analysis of targeted molecular imaging phenotypes appears promising to help elucidate disease pathophysiology and identify potential therapeutic targets...
  3. pmc Alzheimer's Disease Neuroimaging Initiative biomarkers as quantitative phenotypes: Genetics core aims, progress, and plans
    Andrew J Saykin
    Department of Radiology and Imaging Sciences, Center for Neuroimaging, Indiana University School of Medicine, Indianapolis, IN, USA
    Alzheimers Dement 6:265-73. 2010
    ..Genetic studies of longitudinal phenotypes hold promise for elucidating disease mechanisms and risk, development of therapeutic strategies, and refining selection criteria for clinical trials...
  4. pmc Baseline MRI predictors of conversion from MCI to probable AD in the ADNI cohort
    Shannon L Risacher
    IU Center for Neuroimaging, Division of Imaging Sciences, Department of Radiology, Indiana University School of Medicine, 950 W Walnut St, R2 E124, Indianapolis, IN 46202, USA
    Curr Alzheimer Res 6:347-61. 2009
    ..Validation of imaging biomarkers is important as they can help enrich clinical trials of disease modifying agents by identifying individuals at highest risk for progression to AD...
  5. pmc Structural and functional magnetic resonance imaging of autism spectrum disorders
    Kimberly A Stigler
    Christian Sarkine Autism Treatment Center, James Whitcomb Riley Hospital for Children, Indianapolis, IN 46202 5200, USA
    Brain Res 1380:146-61. 2011
    ..Overall, structural and functional MRI research has generated important insights into the neurobiology of ASDs. Additional research is needed to further delineate the underlying brain basis of this constellation of disorders...
  6. pmc Sparse bayesian learning for identifying imaging biomarkers in AD prediction
    Li Shen
    Center for Neuroimaging, Department of Radiology and Imaging Sciences, USA
    Med Image Comput Comput Assist Interv 13:611-8. 2010
    ..While GLM P-map returns significant regions all over the cortex, ARD/PARD provide a small number of relevant and meaningful imaging markers with predictive power, including both cortical and subcortical measures...
  7. pmc Regional reproducibility of pulsed arterial spin labeling perfusion imaging at 3T
    Yang Wang
    IU Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Neuroimage 54:1188-95. 2011
    ..Further reproducibility studies in target populations relevant for specific clinical trials of neurovascular related agents will be important and the present results provide a framework for such assessments...
  8. pmc Gray matter reduction associated with systemic chemotherapy for breast cancer: a prospective MRI study
    Brenna C McDonald
    Center for Neuroimaging, Department of Radiology and Imaging Sciences and the Melvin and Bren Simon Cancer Center, Indiana University School of Medicine, 950 W Walnut St, R2 E124, Indianapolis, IN 46202, USA
    Breast Cancer Res Treat 123:819-28. 2010
    ..These gray matter alterations appear primarily related to the effects of chemotherapy, rather than solely reflecting host factors, the cancer disease process, or effects of other cancer treatments...
  9. pmc Comparison of manual and automated determination of hippocampal volumes in MCI and early AD
    Li Shen
    IU Center for Neuroimaging, Div of Imaging Sciences, Dept of Radiology, Indiana University School of Medicine, 950 W Walnut St, R2 E124, Indianapolis, IN 46202, USA
    Brain Imaging Behav 4:86-95. 2010
    ..These comparisons suggest that FreeSurfer has the potential to be used in automated determination of hippocampal volumes for large-scale MCI/AD-related MRI studies, where manual methods are inefficient or not feasible...
  10. doi request reprint In-home virtual reality videogame telerehabilitation in adolescents with hemiplegic cerebral palsy
    Meredith R Golomb
    Division of Pediatric Neurology, Indiana University School of Medicine, Indianapolis, IN, USA
    Arch Phys Med Rehabil 91:1-8.e1. 2010
    ..Golomb MR, McDonald BC, Warden SJ, Yonkman J, Saykin AJ, Shirley B, Huber M, Rabin B, AbdelBaky M, Nwosu ME, Barkat-Masih M, Burdea GC. In-home virtual reality videogame telerehabilitation in adolescents with hemiplegic cerebral palsy...
  11. pmc Whole genome association study of brain-wide imaging phenotypes for identifying quantitative trait loci in MCI and AD: A study of the ADNI cohort
    Li Shen
    Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, 950 West Walnut Street R2 E124, Indianapolis, IN 46202, USA
    Neuroimage 53:1051-63. 2010
    ..A genome-wide, whole brain search strategy has the potential to reveal novel candidate genes and loci warranting further investigation and replication...
  12. pmc Visual exploration of genetic association with voxel-based imaging phenotypes in an MCI/AD study
    Sungeun Kim
    Center for Neuroimaging, Department of Radiology, Indianapolis, IN 46202, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:3849-52. 2009
    ....
  13. pmc Decreased cancer survival in individuals separated at time of diagnosis: critical period for cancer pathophysiology?
    Gwen C Sprehn
    Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Cancer 115:5108-16. 2009
    ..We examined whether unmarried patients have a different prognosis by whether they are 1) never married, 2) divorced, 3) widowed, or 4) separated at time of diagnosis...
  14. pmc Parametric surface modeling and registration for comparison of manual and automated segmentation of the hippocampus
    Li Shen
    Division of Imaging Sciences, Department of Radiology, IU Center for Neuroimaging, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Hippocampus 19:588-95. 2009
    ..Work is in progress to examine a refined FreeSurfer segmentation strategy and an improved agreement on shape features is expected...
  15. pmc Differences in medication use in the Alzheimer's disease neuroimaging initiative: analysis of baseline characteristics
    Noam U Epstein
    Indiana University School of Medicine, Indianapolis, 46202, USA
    Drugs Aging 27:677-86. 2010
    ..Many participants in the ADNI are being treated with medications, and these may have beneficial or deleterious effects...
  16. pmc Fully automated synthesis and initial PET evaluation of [11C]PBR28
    Min Wang
    Department of Radiology, Indiana University School of Medicine, 950 West Walnut Street, Room 427, Indianapolis, IN 46202, USA
    Bioorg Med Chem Lett 19:5636-9. 2009
    ..These results facilitate the potential preclinical and clinical PET studies of [11C]PBR28 in animals and humans...

Research Grants15

  1. Neural Mechanisms of Chemotherapy-Induced Cognitive Disorder
    Andrew Saykin; Fiscal Year: 2007
    ..abstract_text> ..
  2. Memory Circuitry in MCI and Early Alzheimer's Disease
    Andrew Saykin; Fiscal Year: 2007
    ..This study will yield important new information on neuroimaging and genetic biomarkers for early detection prior to cognitive decline and for assessment of treatment response. ..
  3. Memory Circuitry in MCI and Early Alzheimer's Disease
    Andrew Saykin; Fiscal Year: 2005
    ..abstract_text> ..
  4. Memory Circuitry in MCI and Early Alzheimer's Disease
    Andrew J Saykin; Fiscal Year: 2010
    ..This study will yield important new information on neuroimaging and genetic biomarkers for early detection prior to cognitive decline and for assessment of treatment response. ..