Andrew Saykin

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. pmc Baseline MRI predictors of conversion from MCI to probable AD in the ADNI cohort
    Shannon L Risacher
    IU Center for Neuroimaging, Division of Imaging Sciences, Department of Radiology, Indiana University School of Medicine, 950 W Walnut St, R2 E124, Indianapolis, IN 46202, USA
    Curr Alzheimer Res 6:347-61. 2009
  2. pmc Influence of genetic variation on plasma protein levels in older adults using a multi-analyte panel
    Sungeun Kim
    Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA
    PLoS ONE 8:e70269. 2013
  3. pmc Functional microRNAs in Alzheimer's disease and cancer: differential regulation of common mechanisms and pathway
    Kelly N Holohan
    Department of Medical and Molecular Genetics, Indiana University School of Medicine Indianapolis, IN, USA Training in Research for Behavioral Oncology and Cancer Control Program, Indiana University School of Nursing Indianapolis, IN, USA Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine Indianapolis, IN, USA
    Front Genet 3:323. 2012
  4. pmc Analysis of copy number variation in Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals
    Shanker Swaminathan
    Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
    PLoS ONE 7:e50640. 2012
  5. pmc Genomic Copy Number Analysis in Alzheimer's Disease and Mild Cognitive Impairment: An ADNI Study
    Shanker Swaminathan
    Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Int J Alzheimers Dis 2011:729478. 2011
  6. pmc Neuroimaging biomarkers and cognitive function in non-CNS cancer and its treatment: current status and recommendations for future research
    Andrew J Saykin
    Center for Neuroimaging, Department of Radiology and Imaging Sciences and the Melvin and Bren Simon Cancer Center, Indiana University School of Medicine, 355 W 16th St, Goodman Hall, Suite 4100, Indianapolis, IN, 46202, USA
    Brain Imaging Behav 7:363-73. 2013
  7. pmc Analysis of copy number variation in Alzheimer's disease: the NIALOAD/ NCRAD Family Study
    Shanker Swaminathan
    Department of Radiology and Imaging Sciences, Center for Neuroimaging, Indiana University School of Medicine, Indianapolis, IN, USA
    Curr Alzheimer Res 9:801-14. 2012
  8. pmc Amyloid pathway-based candidate gene analysis of [(11)C]PiB-PET in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort
    Shanker Swaminathan
    Department of Radiology and Imaging Sciences, Center for Neuroimaging, Indiana University School of Medicine, Indianapolis, IN, USA
    Brain Imaging Behav 6:1-15. 2012
  9. pmc Alzheimer's Disease Neuroimaging Initiative biomarkers as quantitative phenotypes: Genetics core aims, progress, and plans
    Andrew J Saykin
    Department of Radiology and Imaging Sciences, Center for Neuroimaging, Indiana University School of Medicine, Indianapolis, IN, USA
    Alzheimers Dement 6:265-73. 2010
  10. pmc Structural and functional magnetic resonance imaging of autism spectrum disorders
    Kimberly A Stigler
    Christian Sarkine Autism Treatment Center, James Whitcomb Riley Hospital for Children, Indianapolis, IN 46202 5200, USA
    Brain Res 1380:146-61. 2011

Detail Information

Publications24

  1. pmc Baseline MRI predictors of conversion from MCI to probable AD in the ADNI cohort
    Shannon L Risacher
    IU Center for Neuroimaging, Division of Imaging Sciences, Department of Radiology, Indiana University School of Medicine, 950 W Walnut St, R2 E124, Indianapolis, IN 46202, USA
    Curr Alzheimer Res 6:347-61. 2009
    ..Validation of imaging biomarkers is important as they can help enrich clinical trials of disease modifying agents by identifying individuals at highest risk for progression to AD...
  2. pmc Influence of genetic variation on plasma protein levels in older adults using a multi-analyte panel
    Sungeun Kim
    Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA
    PLoS ONE 8:e70269. 2013
    ..With intensive searches taking place for proteomic biomarkers for many diseases, the role of genetic variation takes on new importance and should be considered in interpretation of proteomic results...
  3. pmc Functional microRNAs in Alzheimer's disease and cancer: differential regulation of common mechanisms and pathway
    Kelly N Holohan
    Department of Medical and Molecular Genetics, Indiana University School of Medicine Indianapolis, IN, USA Training in Research for Behavioral Oncology and Cancer Control Program, Indiana University School of Nursing Indianapolis, IN, USA Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine Indianapolis, IN, USA
    Front Genet 3:323. 2012
    ..Conclusions from this work may be extended to other neurodegenerative diseases for which some molecular pathways have been identified but which have not yet been extensively researched for miRNA involvement...
  4. pmc Analysis of copy number variation in Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals
    Shanker Swaminathan
    Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
    PLoS ONE 7:e50640. 2012
    ..006, odds ratio = 3.986 (95% confidence interval 1.490-10.667)). A novel APP gene duplication was observed in one case sample. Further investigation of the identified genes in independent and larger samples is warranted...
  5. pmc Genomic Copy Number Analysis in Alzheimer's Disease and Mild Cognitive Impairment: An ADNI Study
    Shanker Swaminathan
    Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Int J Alzheimers Dis 2011:729478. 2011
    ..Replication in larger samples is important, after which regions detected here may be promising targets for resequencing...
  6. pmc Neuroimaging biomarkers and cognitive function in non-CNS cancer and its treatment: current status and recommendations for future research
    Andrew J Saykin
    Center for Neuroimaging, Department of Radiology and Imaging Sciences and the Melvin and Bren Simon Cancer Center, Indiana University School of Medicine, 355 W 16th St, Goodman Hall, Suite 4100, Indianapolis, IN, 46202, USA
    Brain Imaging Behav 7:363-73. 2013
    ..Studies of interventions targeting cognitive changes are also needed. These next steps are expected to identify novel protective strategies and facilitate a more personalized medicine for cancer patients. ..
  7. pmc Analysis of copy number variation in Alzheimer's disease: the NIALOAD/ NCRAD Family Study
    Shanker Swaminathan
    Department of Radiology and Imaging Sciences, Center for Neuroimaging, Indiana University School of Medicine, Indianapolis, IN, USA
    Curr Alzheimer Res 9:801-14. 2012
    ..Replication in independent samples as well as further analyses of these gene regions is warranted...
  8. pmc Amyloid pathway-based candidate gene analysis of [(11)C]PiB-PET in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort
    Shanker Swaminathan
    Department of Radiology and Imaging Sciences, Center for Neuroimaging, Indiana University School of Medicine, Indianapolis, IN, USA
    Brain Imaging Behav 6:1-15. 2012
    ..Pathway-based genetic analysis of targeted molecular imaging phenotypes appears promising to help elucidate disease pathophysiology and identify potential therapeutic targets...
  9. pmc Alzheimer's Disease Neuroimaging Initiative biomarkers as quantitative phenotypes: Genetics core aims, progress, and plans
    Andrew J Saykin
    Department of Radiology and Imaging Sciences, Center for Neuroimaging, Indiana University School of Medicine, Indianapolis, IN, USA
    Alzheimers Dement 6:265-73. 2010
    ..Genetic studies of longitudinal phenotypes hold promise for elucidating disease mechanisms and risk, development of therapeutic strategies, and refining selection criteria for clinical trials...
  10. pmc Structural and functional magnetic resonance imaging of autism spectrum disorders
    Kimberly A Stigler
    Christian Sarkine Autism Treatment Center, James Whitcomb Riley Hospital for Children, Indianapolis, IN 46202 5200, USA
    Brain Res 1380:146-61. 2011
    ..Overall, structural and functional MRI research has generated important insights into the neurobiology of ASDs. Additional research is needed to further delineate the underlying brain basis of this constellation of disorders...
  11. pmc Sparse bayesian learning for identifying imaging biomarkers in AD prediction
    Li Shen
    Center for Neuroimaging, Department of Radiology and Imaging Sciences, USA
    Med Image Comput Comput Assist Interv 13:611-8. 2010
    ..While GLM P-map returns significant regions all over the cortex, ARD/PARD provide a small number of relevant and meaningful imaging markers with predictive power, including both cortical and subcortical measures...
  12. pmc Regional reproducibility of pulsed arterial spin labeling perfusion imaging at 3T
    Yang Wang
    IU Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Neuroimage 54:1188-95. 2011
    ..Further reproducibility studies in target populations relevant for specific clinical trials of neurovascular related agents will be important and the present results provide a framework for such assessments...
  13. pmc Decreased cancer survival in individuals separated at time of diagnosis: critical period for cancer pathophysiology?
    Gwen C Sprehn
    Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Cancer 115:5108-16. 2009
    ..We examined whether unmarried patients have a different prognosis by whether they are 1) never married, 2) divorced, 3) widowed, or 4) separated at time of diagnosis...
  14. pmc Visual exploration of genetic association with voxel-based imaging phenotypes in an MCI/AD study
    Sungeun Kim
    Center for Neuroimaging, Department of Radiology, Indianapolis, IN 46202, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:3849-52. 2009
    ....
  15. pmc Whole genome association study of brain-wide imaging phenotypes for identifying quantitative trait loci in MCI and AD: A study of the ADNI cohort
    Li Shen
    Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, 950 West Walnut Street R2 E124, Indianapolis, IN 46202, USA
    Neuroimage 53:1051-63. 2010
    ..A genome-wide, whole brain search strategy has the potential to reveal novel candidate genes and loci warranting further investigation and replication...
  16. ncbi request reprint In-home virtual reality videogame telerehabilitation in adolescents with hemiplegic cerebral palsy
    Meredith R Golomb
    Division of Pediatric Neurology, Indiana University School of Medicine, Indianapolis, IN, USA
    Arch Phys Med Rehabil 91:1-8.e1. 2010
    ..Golomb MR, McDonald BC, Warden SJ, Yonkman J, Saykin AJ, Shirley B, Huber M, Rabin B, AbdelBaky M, Nwosu ME, Barkat-Masih M, Burdea GC. In-home virtual reality videogame telerehabilitation in adolescents with hemiplegic cerebral palsy...
  17. pmc Comparison of manual and automated determination of hippocampal volumes in MCI and early AD
    Li Shen
    IU Center for Neuroimaging, Div of Imaging Sciences, Dept of Radiology, Indiana University School of Medicine, 950 W Walnut St, R2 E124, Indianapolis, IN 46202, USA
    Brain Imaging Behav 4:86-95. 2010
    ..These comparisons suggest that FreeSurfer has the potential to be used in automated determination of hippocampal volumes for large-scale MCI/AD-related MRI studies, where manual methods are inefficient or not feasible...
  18. pmc Gray matter reduction associated with systemic chemotherapy for breast cancer: a prospective MRI study
    Brenna C McDonald
    Center for Neuroimaging, Department of Radiology and Imaging Sciences and the Melvin and Bren Simon Cancer Center, Indiana University School of Medicine, 950 W Walnut St, R2 E124, Indianapolis, IN 46202, USA
    Breast Cancer Res Treat 123:819-28. 2010
    ..These gray matter alterations appear primarily related to the effects of chemotherapy, rather than solely reflecting host factors, the cancer disease process, or effects of other cancer treatments...
  19. pmc Parametric surface modeling and registration for comparison of manual and automated segmentation of the hippocampus
    Li Shen
    Division of Imaging Sciences, Department of Radiology, IU Center for Neuroimaging, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Hippocampus 19:588-95. 2009
    ..Work is in progress to examine a refined FreeSurfer segmentation strategy and an improved agreement on shape features is expected...
  20. pmc Differences in medication use in the Alzheimer's disease neuroimaging initiative: analysis of baseline characteristics
    Noam U Epstein
    Indiana University School of Medicine, Indianapolis, 46202, USA
    Drugs Aging 27:677-86. 2010
    ..Many participants in the ADNI are being treated with medications, and these may have beneficial or deleterious effects...
  21. pmc Mild cognitive impairment: baseline and longitudinal structural MR imaging measures improve predictive prognosis
    Linda K McEvoy
    Department of Radiology, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA
    Radiology 259:834-43. 2011
    ..To assess whether single-time-point and longitudinal volumetric magnetic resonance (MR) imaging measures provide predictive prognostic information in patients with amnestic mild cognitive impairment (MCI)...
  22. pmc Subscale validation of the neuropsychiatric inventory questionnaire: comparison of Alzheimer's disease neuroimaging initiative and national Alzheimer's coordinating center cohorts
    Paula T Trzepacz
    Eli Lilly and Company, Indianapolis, IN 46285, USA
    Am J Geriatr Psychiatry 21:607-22. 2013
    ..Based on existing exploratory literature, we report preliminary validation of three NPI Questionnaire (NPI-Q-10) subscales that measure clinically meaningful symptom clusters...
  23. pmc Fully automated synthesis and initial PET evaluation of [11C]PBR28
    Min Wang
    Department of Radiology, Indiana University School of Medicine, 950 West Walnut Street, Room 427, Indianapolis, IN 46202, USA
    Bioorg Med Chem Lett 19:5636-9. 2009
    ..These results facilitate the potential preclinical and clinical PET studies of [11C]PBR28 in animals and humans...

Research Grants15

  1. Memory Circuitry in MCI and Early Alzheimer's Disease
    Andrew Saykin; Fiscal Year: 2001
    ..abstract_text> ..
  2. Memory Circuitry in MCI and Early Alzheimer's Disease
    Andrew Saykin; Fiscal Year: 2009
    ..This study will yield important new information on neuroimaging and genetic biomarkers for early detection prior to cognitive decline and for assessment of treatment response. ..
  3. Neural Mechanisms of Chemotherapy-Induced Cognitive Disorder
    Andrew Saykin; Fiscal Year: 2007
    ..abstract_text> ..
  4. Memory Circuitry in MCI and Early Alzheimer's Disease
    Andrew Saykin; Fiscal Year: 2007
    ..This study will yield important new information on neuroimaging and genetic biomarkers for early detection prior to cognitive decline and for assessment of treatment response. ..
  5. Neural Mechanisms of Chemotherapy-Induced Cognitive Dis
    Andrew Saykin; Fiscal Year: 2006
    ..abstract_text> ..
  6. Neural Mechanisms of Chemotherapy-Induced Cognitive Dis
    Andrew Saykin; Fiscal Year: 2005
    ..abstract_text> ..
  7. Memory Circuitry in MCI and Early Alzheimer's Disease
    Andrew Saykin; Fiscal Year: 2005
    ..abstract_text> ..
  8. Memory Circuitry in MCI and Early Alzheimer's Disease
    Andrew Saykin; Fiscal Year: 2004
    ..abstract_text> ..
  9. Neural Mechanisms of Chemotherapy-Induced Cognitive Dis
    Andrew Saykin; Fiscal Year: 2004
    ..abstract_text> ..
  10. Neural Mechanisms of Chemotherapy-Induced Cognitive Dis
    Andrew Saykin; Fiscal Year: 2003
    ..abstract_text> ..
  11. Memory Circuitry in MCI and Early Alzheimer's Disease
    Andrew Saykin; Fiscal Year: 2003
    ..abstract_text> ..
  12. Memory Circuitry in MCI and Early Alzheimer's Disease
    Andrew Saykin; Fiscal Year: 2002
    ..abstract_text> ..
  13. Memory Circuitry in MCI and Early Alzheimer's Disease
    Andrew J Saykin; Fiscal Year: 2010
    ..This study will yield important new information on neuroimaging and genetic biomarkers for early detection prior to cognitive decline and for assessment of treatment response. ..