Research Topics
| D E RusyniakSummaryAffiliation: Indiana University Country: USA Publications
Research Grants
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Detail Information
Publications
Attenuation of 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy)-induced rhabdomyolysis with alpha1- plus beta3-adrenoreceptor antagonistsJon E Sprague
The Department of Pharmaceutical and Biomedical Sciences, The Raabe College of Pharmacy, Ohio Northern University, Ada, OH 45810, USA
Br J Pharmacol 142:667-70. 2004..5. The results from this study suggest that alpha(1)AR and beta(3)AR play a critical role in the etiology of MDMA-mediated hyperthermia and subsequent rhabdomyolysis...- Life-threatening hyperkalemia from cream of tartar ingestionDaniel E Rusyniak
Department of Emergency Medicine, Indiana University School of Medicine, 1050 Wishard Blvd, RG R2200, Indianapolis, IN, 46202, USA
J Med Toxicol 9:79-81. 2013..We report two cases in which intentional ingestions of cream of tartar resulted in life-threatening hyperkalemia. In addition, we briefly review the use of cream of tartar as a historical purgative... - The orexin-1 receptor antagonist SB-334867 decreases sympathetic responses to a moderate dose of methamphetamine and stressDaniel E Rusyniak
Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, United States
Physiol Behav 107:743-50. 2012..The failure to affect a low and a high dose of METH suggests a complex pharmacology dependent on dose. A better understanding of this may lead to the knowledge of how monoamines influence the orexin system and vice versa... 
Hyperthermic syndromes induced by toxinsDaniel E Rusyniak
Division of Medical Toxicology, Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Clin Lab Med 26:165-84, ix. 2006..Current treatment recommendations and future trends in treatment are also discussed...- Historical neurotoxins: what we have learned from toxins of the past about diseases of the presentDaniel E Rusyniak
Division of Medical Toxicology, Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN 46202 2859, USA
Neurol Clin 23:337-52. 2005.... - The role of mitochondrial uncoupling in 3,4-methylenedioxymethamphetamine-mediated skeletal muscle hyperthermia and rhabdomyolysisDaniel E Rusyniak
Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, 46202, USA
J Pharmacol Exp Ther 313:629-39. 2005..These findings suggest that MDMA uncouples skeletal muscle mitochondria in vivo but that this uncoupling is the result of indirect mechanisms... - 3,4-Methylenedioxymethamphetamine- and 8-hydroxy-2-di-n-propylamino-tetralin-induced hypothermia: role and location of 5-hydroxytryptamine 1A receptorsDaniel E Rusyniak
Departments of Emergency Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
J Pharmacol Exp Ther 323:477-87. 2007..These results demonstrate that although hypothermia mediated by both MDMA and DPAT shares a common dependence on the activation of 5-HT(1A) receptors, the location of these receptors is different for each drug... - When administered to rats in a cold environment, 3,4-methylenedioxymethamphetamine reduces brown adipose tissue thermogenesis and increases tail blood flow: effects of pretreatment with 5-HT1A and dopamine D2 antagonistsD E Rusyniak
Departments of Emergency Medicine and Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Neuroscience 154:1619-26. 2008.... - Microinjection of muscimol into the dorsomedial hypothalamus suppresses MDMA-evoked sympathetic and behavioral responsesDaniel E Rusyniak
Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN 46202 2859, USA
Brain Res 1226:116-23. 2008..These results indicate that neuronal activity in the DMH is necessary for the sympathetic and behavioral responses evoked by MDMA... 
Conservative management of elemental mercury retained in the appendixDaniel E Rusyniak
Indiana University School of Medicine, Department of Emergency Medicine, Indianapolis, Indiana 46202, USA
Clin Toxicol (Phila) 46:831-3. 2008..We report a case in which a patient with mercury retained in the appendix was managed conservatively without developing mercurialism or appendicitis...- Heavy metal poisoning: management of intoxication and antidotesDaniel E Rusyniak
Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
EXS 100:365-96. 2010..For some metals there are no physiological concentrations that are beneficial; as such these metals only have the potential to cause toxicity. This chapter focuses on four of these: arsenic, mercury, lead and thallium... - Dimercaptosuccinic acid and Prussian Blue in the treatment of acute thallium poisoning in ratsDaniel E Rusyniak
Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
J Toxicol Clin Toxicol 41:137-42. 2003..The objective of this study was to determine the efficacy of DMSA as a treatment for thallium poisoning by studying mortality and whole-brain concentrations in thallium poisoned rats... - Hyperbaric oxygen therapy in acute ischemic stroke: results of the Hyperbaric Oxygen in Acute Ischemic Stroke Trial Pilot StudyDaniel E Rusyniak
Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, USA
Stroke 34:571-4. 2003..Hyperbaric oxygen therapy (HBO) has promise as a treatment for acute stroke. This study was conducted to evaluate the efficacy, safety, and feasibility of using HBO in acute ischemic stroke... - Neurologic manifestations of chronic methamphetamine abuseDaniel E Rusyniak
Department of Emergency Medicine, Indiana University School of Medicine, 1050 Wishard Boulevard, Room 2200, Indianapolis, IN 46202, USA
Neurol Clin 29:641-55. 2011.... - Increase in plasma ACTH induced by urethane is not a consequence of hyperosmolalityDmitry V Zaretsky
Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Neurosci Lett 479:10-2. 2010..Thus, increases in plasma ACTH seen after anesthetic doses of urethane are unlikely to be a consequence of its effect on plasma osmolality... - A prospective, randomized, double-blind comparison of buffered versus plain tetracaine in reducing the pain of topical ophthalmic anesthesiaChristopher S Weaver
Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Ann Emerg Med 41:827-31. 2003..We determine whether buffering ocular tetracaine hydrochloride reduces the pain of instillation... - Impact of emergency medicine faculty and an airway protocol on airway managementJames H Jones
Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
Acad Emerg Med 9:1452-6. 2002..To determine the impact of emergency medicine (EM) faculty presence and an airway management protocol on success rates of tracheal intubation in the emergency department (ED)... - Toxin-induced hyperthermic syndromesDaniel E Rusyniak
Division of Medical Toxicology, Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Med Clin North Am 89:1277-96. 2005..The treatment of MH involves the use of dantrolene. Future improvements in understanding the pathophysiology and clinical presentations of these syndromes will undoubtedly result in earlier recognition and better treatment strategies... - Heavy metal poisoning: clinical presentations and pathophysiologyDanyal Ibrahim
Department of Emergency Medicine, Division of Medical Toxicology, Indiana University School of Medicine, 1050 Wishard Boulevard, Room 2200, Indianapolis, IN 46202, USA
Clin Lab Med 26:67-97, viii. 2006..Their easy acquisition and potent toxicity have also made them popular choices for criminal poisonings. This article examines the clinical manifestation and pathophysiology of poisoning from lead, mercury, arsenic, and thallium... - Pearls and pitfalls in the approach to patients with neurotoxic syndromesD E Rusyniak
Division of Medical Toxicology, Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202-2856, USA
Semin Neurol 21:407-16. 2001..This approach is discussed in the following article in an attempt to bring structure to solving problems in a complex area of medicine... - Thallium and arsenic poisoning in a small midwestern townDaniel E Rusyniak
Department of Emergency Medicine and Division of Medical Toxicology, Indiana University School of Medicine, Indianapolis, IN, USA
Ann Emerg Med 39:307-11. 2002..Thallium remains a means of criminal poisoning and should be considered in any patient with a rapidly progressing peripheral neuropathy with or without alopecia... - Cerebrovascular and cardiovascular complications of alcohol and sympathomimetic drug abuseAyrn D O'Connor
Department of Emergency Medicine, Iniana University School of Medicine, Indianapolis, IN, USA
Med Clin North Am 89:1343-58. 2005..Because many complications of alcohol and stimulant abuse are preventable and reversible, it is important to screen for these in patients with cerebrovascular and cardiovascular disease... - Organophosphate poisoningDaniel E Rusyniak
Assistant Professor, Departments of Emergency Medicine, Pharmacology and Toxicology, and Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA
Semin Neurol 24:197-204. 2004..Clinical features and management of organophosphate poisoning is reviewed with emphasis on those affecting the central and peripheral nervous system... - The effects of ecstasy (MDMA) on rat liver bioenergeticsDaniel E Rusyniak
Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
Acad Emerg Med 11:723-9. 2004..These data do not support the view that the hyperthermia induced by MDMA is from a direct effect on mitochondrial oxidative phosphorylation... - Absinthe: return of the Green FairyChristopher P Holstege
Division of Medical Toxicology, Department of Emergency Medicine, University of Virginia, Charlottesville, Virginia, USA
Semin Neurol 22:89-93. 2002..This paper reviews some of the historical aspects of absinthe and aims to shed light on the mechanism of action and neurotoxicology of this the Green Fairy... - The role of the sympathetic nervous system and uncoupling proteins in the thermogenesis induced by 3,4-methylenedioxymethamphetamineEdward M Mills
The National Heart, Lung and Blood Institute, NIH, Bethesda, MD 20892-1770, USA
J Mol Med 82:787-99. 2004..This review examines cellular mechanisms involved in MDMA-induced thermogenesis from UCP activation to vasoconstriction and how these mechanisms are related to other thermogenic conditions and potential treatment modalities... - UCP3 and thyroid hormone involvement in methamphetamine-induced hyperthermiaJon E Sprague
The Department of Pharmaceutical and Biomedical Sciences, The Raabe College of Pharmacy, Ohio Northern University, Ada, OH 45810, USA
Biochem Pharmacol 68:1339-43. 2004..The relationship of these results to the hyperthermia induced by 3,4-methylenedioxymethamphetamine (MDMA) is also discussed... - Dantrolene use in 3,4-methylenedioxymethamphetamine (ecstasy)-mediated hyperthermiaDaniel E Rusyniak
Anesthesiology 101:263; author reply 264. 2004 - Productivity and career paths of previous recipients of Society for Academic Emergency Medicine research grant awardsKelly D Young
Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Acad Emerg Med 15:560-6. 2008..The objective was to assess productivity of previous recipients of Society for Academic Emergency Medicine (SAEM) grant awards... - Carvedilol reverses hyperthermia and attenuates rhabdomyolysis induced by 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy) in an animal modelJon E Sprague
Department of Pharmaceutical and Biomedical Sciences, The Raabe College of Pharmacy, Ohio Northern University, Ada, OH, USA
Crit Care Med 33:1311-6. 2005....
Research Grants
- Ecstasy and the Dorsomedial HypothalamusDANIEL RUSYNIAK; Fiscal Year: 2007....
- CNS circuitry and receptors mediating the effects of MDMADaniel E Rusyniak; Fiscal Year: 2010..By identifying the brain areas and chemical receptors responsible for causing MDMA's toxicity, our research may lead to new and innovative treatments. ..