D E Rusyniak

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. pmc Attenuation of 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy)-induced rhabdomyolysis with alpha1- plus beta3-adrenoreceptor antagonists
    Jon E Sprague
    The Department of Pharmaceutical and Biomedical Sciences, The Raabe College of Pharmacy, Ohio Northern University, Ada, OH 45810, USA
    Br J Pharmacol 142:667-70. 2004
  2. pmc Neurologic manifestations of chronic methamphetamine abuse
    Daniel E Rusyniak
    Department of Emergency Medicine, Indiana University School of Medicine, 1050 Wishard Boulevard, Room 2200, Indianapolis, IN 46202, USA
    Psychiatr Clin North Am 36:261-75. 2013
  3. pmc Life-threatening hyperkalemia from cream of tartar ingestion
    Daniel E Rusyniak
    Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Med Toxicol 9:79-81. 2013
  4. pmc The orexin-1 receptor antagonist SB-334867 decreases sympathetic responses to a moderate dose of methamphetamine and stress
    Daniel E Rusyniak
    Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, United States
    Physiol Behav 107:743-50. 2012
  5. pmc Microinjection of muscimol into the dorsomedial hypothalamus suppresses MDMA-evoked sympathetic and behavioral responses
    Daniel E Rusyniak
    Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN 46202 2859, USA
    Brain Res 1226:116-23. 2008
  6. pmc When administered to rats in a cold environment, 3,4-methylenedioxymethamphetamine reduces brown adipose tissue thermogenesis and increases tail blood flow: effects of pretreatment with 5-HT1A and dopamine D2 antagonists
    D E Rusyniak
    Departments of Emergency Medicine and Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Neuroscience 154:1619-26. 2008
  7. ncbi request reprint The role of mitochondrial uncoupling in 3,4-methylenedioxymethamphetamine-mediated skeletal muscle hyperthermia and rhabdomyolysis
    Daniel E Rusyniak
    Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, 46202, USA
    J Pharmacol Exp Ther 313:629-39. 2005
  8. ncbi request reprint Historical neurotoxins: what we have learned from toxins of the past about diseases of the present
    Daniel E Rusyniak
    Division of Medical Toxicology, Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN 46202 2859, USA
    Neurol Clin 23:337-52. 2005
  9. ncbi request reprint 3,4-Methylenedioxymethamphetamine- and 8-hydroxy-2-di-n-propylamino-tetralin-induced hypothermia: role and location of 5-hydroxytryptamine 1A receptors
    Daniel E Rusyniak
    Departments of Emergency Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    J Pharmacol Exp Ther 323:477-87. 2007
  10. ncbi request reprint Hyperthermic syndromes induced by toxins
    Daniel E Rusyniak
    Division of Medical Toxicology, Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Clin Lab Med 26:165-84, ix. 2006

Research Grants

  1. Ecstasy and the Dorsomedial Hypothalamus
    DANIEL RUSYNIAK; Fiscal Year: 2007
  2. CNS circuitry and receptors mediating the effects of MDMA
    Daniel E Rusyniak; Fiscal Year: 2010

Detail Information

Publications31

  1. pmc Attenuation of 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy)-induced rhabdomyolysis with alpha1- plus beta3-adrenoreceptor antagonists
    Jon E Sprague
    The Department of Pharmaceutical and Biomedical Sciences, The Raabe College of Pharmacy, Ohio Northern University, Ada, OH 45810, USA
    Br J Pharmacol 142:667-70. 2004
    ..5. The results from this study suggest that alpha(1)AR and beta(3)AR play a critical role in the etiology of MDMA-mediated hyperthermia and subsequent rhabdomyolysis...
  2. pmc Neurologic manifestations of chronic methamphetamine abuse
    Daniel E Rusyniak
    Department of Emergency Medicine, Indiana University School of Medicine, 1050 Wishard Boulevard, Room 2200, Indianapolis, IN 46202, USA
    Psychiatr Clin North Am 36:261-75. 2013
    ..Understanding the chronic neurologic manifestations of Meth abuse will better arm practitioners with the diagnostic and therapeutic tools needed to make the Meth epidemic one of historical interest only...
  3. pmc Life-threatening hyperkalemia from cream of tartar ingestion
    Daniel E Rusyniak
    Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Med Toxicol 9:79-81. 2013
    ..We report two cases in which intentional ingestions of cream of tartar resulted in life-threatening hyperkalemia. In addition, we briefly review the use of cream of tartar as a historical purgative...
  4. pmc The orexin-1 receptor antagonist SB-334867 decreases sympathetic responses to a moderate dose of methamphetamine and stress
    Daniel E Rusyniak
    Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, United States
    Physiol Behav 107:743-50. 2012
    ..The failure to affect a low and a high dose of METH suggests a complex pharmacology dependent on dose. A better understanding of this may lead to the knowledge of how monoamines influence the orexin system and vice versa...
  5. pmc Microinjection of muscimol into the dorsomedial hypothalamus suppresses MDMA-evoked sympathetic and behavioral responses
    Daniel E Rusyniak
    Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN 46202 2859, USA
    Brain Res 1226:116-23. 2008
    ..These results indicate that neuronal activity in the DMH is necessary for the sympathetic and behavioral responses evoked by MDMA...
  6. pmc When administered to rats in a cold environment, 3,4-methylenedioxymethamphetamine reduces brown adipose tissue thermogenesis and increases tail blood flow: effects of pretreatment with 5-HT1A and dopamine D2 antagonists
    D E Rusyniak
    Departments of Emergency Medicine and Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Neuroscience 154:1619-26. 2008
    ....
  7. ncbi request reprint The role of mitochondrial uncoupling in 3,4-methylenedioxymethamphetamine-mediated skeletal muscle hyperthermia and rhabdomyolysis
    Daniel E Rusyniak
    Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, 46202, USA
    J Pharmacol Exp Ther 313:629-39. 2005
    ..These findings suggest that MDMA uncouples skeletal muscle mitochondria in vivo but that this uncoupling is the result of indirect mechanisms...
  8. ncbi request reprint Historical neurotoxins: what we have learned from toxins of the past about diseases of the present
    Daniel E Rusyniak
    Division of Medical Toxicology, Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN 46202 2859, USA
    Neurol Clin 23:337-52. 2005
    ....
  9. ncbi request reprint 3,4-Methylenedioxymethamphetamine- and 8-hydroxy-2-di-n-propylamino-tetralin-induced hypothermia: role and location of 5-hydroxytryptamine 1A receptors
    Daniel E Rusyniak
    Departments of Emergency Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    J Pharmacol Exp Ther 323:477-87. 2007
    ..These results demonstrate that although hypothermia mediated by both MDMA and DPAT shares a common dependence on the activation of 5-HT(1A) receptors, the location of these receptors is different for each drug...
  10. ncbi request reprint Hyperthermic syndromes induced by toxins
    Daniel E Rusyniak
    Division of Medical Toxicology, Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Clin Lab Med 26:165-84, ix. 2006
    ..Current treatment recommendations and future trends in treatment are also discussed...
  11. doi request reprint Conservative management of elemental mercury retained in the appendix
    Daniel E Rusyniak
    Indiana University School of Medicine, Department of Emergency Medicine, Indianapolis, Indiana 46202, USA
    Clin Toxicol (Phila) 46:831-3. 2008
    ..We report a case in which a patient with mercury retained in the appendix was managed conservatively without developing mercurialism or appendicitis...
  12. ncbi request reprint Heavy metal poisoning: management of intoxication and antidotes
    Daniel E Rusyniak
    Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    EXS 100:365-96. 2010
    ..For some metals there are no physiological concentrations that are beneficial; as such these metals only have the potential to cause toxicity. This chapter focuses on four of these: arsenic, mercury, lead and thallium...
  13. pmc Neurologic manifestations of chronic methamphetamine abuse
    Daniel E Rusyniak
    Department of Emergency Medicine, Indiana University School of Medicine, 1050 Wishard Boulevard, Room 2200, Indianapolis, IN 46202, USA
    Neurol Clin 29:641-55. 2011
    ....
  14. ncbi request reprint Dimercaptosuccinic acid and Prussian Blue in the treatment of acute thallium poisoning in rats
    Daniel E Rusyniak
    Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    J Toxicol Clin Toxicol 41:137-42. 2003
    ..The objective of this study was to determine the efficacy of DMSA as a treatment for thallium poisoning by studying mortality and whole-brain concentrations in thallium poisoned rats...
  15. ncbi request reprint Hyperbaric oxygen therapy in acute ischemic stroke: results of the Hyperbaric Oxygen in Acute Ischemic Stroke Trial Pilot Study
    Daniel E Rusyniak
    Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, USA
    Stroke 34:571-4. 2003
    ..Hyperbaric oxygen therapy (HBO) has promise as a treatment for acute stroke. This study was conducted to evaluate the efficacy, safety, and feasibility of using HBO in acute ischemic stroke...
  16. pmc Increase in plasma ACTH induced by urethane is not a consequence of hyperosmolality
    Dmitry V Zaretsky
    Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Neurosci Lett 479:10-2. 2010
    ..Thus, increases in plasma ACTH seen after anesthetic doses of urethane are unlikely to be a consequence of its effect on plasma osmolality...
  17. ncbi request reprint A prospective, randomized, double-blind comparison of buffered versus plain tetracaine in reducing the pain of topical ophthalmic anesthesia
    Christopher S Weaver
    Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Ann Emerg Med 41:827-31. 2003
    ..We determine whether buffering ocular tetracaine hydrochloride reduces the pain of instillation...
  18. ncbi request reprint Toxin-induced hyperthermic syndromes
    Daniel E Rusyniak
    Division of Medical Toxicology, Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Med Clin North Am 89:1277-96. 2005
    ..The treatment of MH involves the use of dantrolene. Future improvements in understanding the pathophysiology and clinical presentations of these syndromes will undoubtedly result in earlier recognition and better treatment strategies...
  19. ncbi request reprint Impact of emergency medicine faculty and an airway protocol on airway management
    James H Jones
    Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Acad Emerg Med 9:1452-6. 2002
    ..To determine the impact of emergency medicine (EM) faculty presence and an airway management protocol on success rates of tracheal intubation in the emergency department (ED)...
  20. ncbi request reprint Heavy metal poisoning: clinical presentations and pathophysiology
    Danyal Ibrahim
    Department of Emergency Medicine, Division of Medical Toxicology, Indiana University School of Medicine, 1050 Wishard Boulevard, Room 2200, Indianapolis, IN 46202, USA
    Clin Lab Med 26:67-97, viii. 2006
    ..Their easy acquisition and potent toxicity have also made them popular choices for criminal poisonings. This article examines the clinical manifestation and pathophysiology of poisoning from lead, mercury, arsenic, and thallium...
  21. ncbi request reprint Pearls and pitfalls in the approach to patients with neurotoxic syndromes
    D E Rusyniak
    Division of Medical Toxicology, Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202-2856, USA
    Semin Neurol 21:407-16. 2001
    ..This approach is discussed in the following article in an attempt to bring structure to solving problems in a complex area of medicine...
  22. ncbi request reprint Thallium and arsenic poisoning in a small midwestern town
    Daniel E Rusyniak
    Department of Emergency Medicine and Division of Medical Toxicology, Indiana University School of Medicine, Indianapolis, IN, USA
    Ann Emerg Med 39:307-11. 2002
    ..Thallium remains a means of criminal poisoning and should be considered in any patient with a rapidly progressing peripheral neuropathy with or without alopecia...
  23. ncbi request reprint Cerebrovascular and cardiovascular complications of alcohol and sympathomimetic drug abuse
    Ayrn D O'Connor
    Department of Emergency Medicine, Iniana University School of Medicine, Indianapolis, IN, USA
    Med Clin North Am 89:1343-58. 2005
    ..Because many complications of alcohol and stimulant abuse are preventable and reversible, it is important to screen for these in patients with cerebrovascular and cardiovascular disease...
  24. ncbi request reprint Absinthe: return of the Green Fairy
    Christopher P Holstege
    Division of Medical Toxicology, Department of Emergency Medicine, University of Virginia, Charlottesville, Virginia, USA
    Semin Neurol 22:89-93. 2002
    ..This paper reviews some of the historical aspects of absinthe and aims to shed light on the mechanism of action and neurotoxicology of this the Green Fairy...
  25. ncbi request reprint The effects of ecstasy (MDMA) on rat liver bioenergetics
    Daniel E Rusyniak
    Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Acad Emerg Med 11:723-9. 2004
    ..In the present study, the authors tested the hypothesis that MDMA directly uncouples oxidative phosphorylation in rat liver mitochondria...
  26. ncbi request reprint Organophosphate poisoning
    Daniel E Rusyniak
    Assistant Professor, Departments of Emergency Medicine, Pharmacology and Toxicology, and Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Semin Neurol 24:197-204. 2004
    ..Clinical features and management of organophosphate poisoning is reviewed with emphasis on those affecting the central and peripheral nervous system...
  27. ncbi request reprint UCP3 and thyroid hormone involvement in methamphetamine-induced hyperthermia
    Jon E Sprague
    The Department of Pharmaceutical and Biomedical Sciences, The Raabe College of Pharmacy, Ohio Northern University, Ada, OH 45810, USA
    Biochem Pharmacol 68:1339-43. 2004
    ..The relationship of these results to the hyperthermia induced by 3,4-methylenedioxymethamphetamine (MDMA) is also discussed...
  28. ncbi request reprint The role of the sympathetic nervous system and uncoupling proteins in the thermogenesis induced by 3,4-methylenedioxymethamphetamine
    Edward M Mills
    The National Heart, Lung and Blood Institute, NIH, Bethesda, MD 20892 1770, USA
    J Mol Med (Berl) 82:787-99. 2004
    ..This review examines cellular mechanisms involved in MDMA-induced thermogenesis from UCP activation to vasoconstriction and how these mechanisms are related to other thermogenic conditions and potential treatment modalities...
  29. doi request reprint Productivity and career paths of previous recipients of Society for Academic Emergency Medicine research grant awards
    Kelly D Young
    Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Acad Emerg Med 15:560-6. 2008
    ..The objective was to assess productivity of previous recipients of Society for Academic Emergency Medicine (SAEM) grant awards...
  30. ncbi request reprint Dantrolene use in 3,4-methylenedioxymethamphetamine (ecstasy)-mediated hyperthermia
    Daniel E Rusyniak
    Anesthesiology 101:263; author reply 264. 2004
  31. ncbi request reprint Carvedilol reverses hyperthermia and attenuates rhabdomyolysis induced by 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy) in an animal model
    Jon E Sprague
    Department of Pharmaceutical and Biomedical Sciences, The Raabe College of Pharmacy, Ohio Northern University, Ada, OH, USA
    Crit Care Med 33:1311-6. 2005
    ..Using a rat model of MDMA hyperthermia, we evaluated the acute drug-induced changes in plasma catecholamines and used these results as a basis for the selection of drugs that could potentially reverse this hyperthermia...

Research Grants3

  1. Ecstasy and the Dorsomedial Hypothalamus
    DANIEL RUSYNIAK; Fiscal Year: 2007
    ....
  2. CNS circuitry and receptors mediating the effects of MDMA
    Daniel E Rusyniak; Fiscal Year: 2010
    ..By identifying the brain areas and chemical receptors responsible for causing MDMA's toxicity, our research may lead to new and innovative treatments. ..