Z A Rodd

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. ncbi request reprint Effects of concurrent access to multiple ethanol concentrations and repeated deprivations on alcohol intake of alcohol-preferring rats
    Z A Rodd-Henricks
    Department of Psychiatry, Indiana University School of Medicine and Veterans Assistance Medical Center, Indianapolis, Indiana 46202 4887, USA
    Alcohol Clin Exp Res 25:1140-50. 2001
  2. ncbi request reprint The reinforcing effects of acetaldehyde in the posterior ventral tegmental area of alcohol-preferring rats
    Zachary A Rodd-Henricks
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, 791 Union Drive, Indianapolis, IN 46202 4887, USA
    Pharmacol Biochem Behav 72:55-64. 2002
  3. ncbi request reprint Serotonin-3 receptors in the actions of alcohol, alcohol reinforcement, and alcoholism
    William J McBride
    Indiana University School of Medicine, Indianapolis, Indiana, USA
    Alcohol Clin Exp Res 28:257-67. 2004
  4. ncbi request reprint Recent advances in animal models of alcohol craving and relapse
    Zachary A Rodd
    Institute of Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, 791 Union Drive, Indianapolis, IN 46202 4887, USA
    Pharmacol Biochem Behav 79:439-50. 2004
  5. ncbi request reprint Alcohol effects on central nervous system gene expression in genetic animal models
    William J McBride
    Indiana University School of Medicine, Indianapolis, Indiana, USA
    Alcohol Clin Exp Res 29:167-75. 2005
  6. ncbi request reprint The expression of an alcohol deprivation effect in the high-alcohol-drinking replicate rat lines is dependent on repeated deprivations
    Z A Rodd-Henricks
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine and VA Medical Center, Indiana University Purdue University at Indianapolis, 46202 4887, USA
    Alcohol Clin Exp Res 24:747-53. 2000
  7. ncbi request reprint Comparison of intracranial self-administration of ethanol within the posterior ventral tegmental area between alcohol-preferring and Wistar rats
    Zachary A Rodd
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46202 4887, USA
    Alcohol Clin Exp Res 28:1212-9. 2004
  8. ncbi request reprint Regional heterogeneity for the intracranial self-administration of ethanol and acetaldehyde within the ventral tegmental area of alcohol-preferring (P) rats: involvement of dopamine and serotonin
    Zachary A Rodd
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University Purdue University at Indianapolis, Indianapolis, IN, USA
    Neuropsychopharmacology 30:330-8. 2005
  9. pmc Effects of concurrent access to multiple ethanol concentrations and repeated deprivations on alcohol intake of high-alcohol-drinking (HAD) rats
    Zachary A Rodd
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicne, USA
    Addict Biol 14:152-64. 2009
  10. doi request reprint Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats
    Zachary A Rodd
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202 4887, United States
    Pharmacol Biochem Behav 89:481-98. 2008

Research Grants

  1. Gene expression associated with the CNS reinforcing act*
    ZACHARY RODD HENRICKS; Fiscal Year: 2003

Detail Information

Publications59

  1. ncbi request reprint Effects of concurrent access to multiple ethanol concentrations and repeated deprivations on alcohol intake of alcohol-preferring rats
    Z A Rodd-Henricks
    Department of Psychiatry, Indiana University School of Medicine and Veterans Assistance Medical Center, Indianapolis, Indiana 46202 4887, USA
    Alcohol Clin Exp Res 25:1140-50. 2001
    ..This study examined the effects of initial deprivation length, concurrent exposure to multiple ethanol concentrations, and number of deprivation exposures on the magnitude and duration of the ADE in alcohol-preferring (P) rats...
  2. ncbi request reprint The reinforcing effects of acetaldehyde in the posterior ventral tegmental area of alcohol-preferring rats
    Zachary A Rodd-Henricks
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, 791 Union Drive, Indianapolis, IN 46202 4887, USA
    Pharmacol Biochem Behav 72:55-64. 2002
    ..P rats maintained similar numbers of infusions and infusion patterns under both time-out schedules. Overall, the data indicate that ACD is a potent reinforcer within the posterior VTA of the P rat...
  3. ncbi request reprint Serotonin-3 receptors in the actions of alcohol, alcohol reinforcement, and alcoholism
    William J McBride
    Indiana University School of Medicine, Indianapolis, Indiana, USA
    Alcohol Clin Exp Res 28:257-67. 2004
    ..Rodd and James M. Murphy; and (4) Ondansetron as a treatment for "biological" alcoholism, by John D. Roache and Bankole A. Johnson...
  4. ncbi request reprint Recent advances in animal models of alcohol craving and relapse
    Zachary A Rodd
    Institute of Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, 791 Union Drive, Indianapolis, IN 46202 4887, USA
    Pharmacol Biochem Behav 79:439-50. 2004
    ..Overall, the findings indicate substantial progress has been made in developing animal models of alcohol abuse, relapse and craving using these selectively bred rat lines, as well as outbred rats...
  5. ncbi request reprint Alcohol effects on central nervous system gene expression in genetic animal models
    William J McBride
    Indiana University School of Medicine, Indianapolis, Indiana, USA
    Alcohol Clin Exp Res 29:167-75. 2005
    ..Hashimoto and Kristine M. Wiren...
  6. ncbi request reprint The expression of an alcohol deprivation effect in the high-alcohol-drinking replicate rat lines is dependent on repeated deprivations
    Z A Rodd-Henricks
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine and VA Medical Center, Indiana University Purdue University at Indianapolis, 46202 4887, USA
    Alcohol Clin Exp Res 24:747-53. 2000
    ..In the current study, we examined the effects of initial deprivation length and number of deprivation exposures on the ADE in the replicate lines of the high-alcohol-drinking (HAD) rats...
  7. ncbi request reprint Comparison of intracranial self-administration of ethanol within the posterior ventral tegmental area between alcohol-preferring and Wistar rats
    Zachary A Rodd
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46202 4887, USA
    Alcohol Clin Exp Res 28:1212-9. 2004
    ....
  8. ncbi request reprint Regional heterogeneity for the intracranial self-administration of ethanol and acetaldehyde within the ventral tegmental area of alcohol-preferring (P) rats: involvement of dopamine and serotonin
    Zachary A Rodd
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University Purdue University at Indianapolis, Indianapolis, IN, USA
    Neuropsychopharmacology 30:330-8. 2005
    ..Furthermore, activation of 5-HT3 receptors within the posterior VTA is involved in the self-infusion of EtOH, but not ACD...
  9. pmc Effects of concurrent access to multiple ethanol concentrations and repeated deprivations on alcohol intake of high-alcohol-drinking (HAD) rats
    Zachary A Rodd
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicne, USA
    Addict Biol 14:152-64. 2009
    ..The results indicate that HAD rats exhibit 'loss-of-control' of alcohol drinking with repeated deprivations when multiple ethanol concentrations are available...
  10. doi request reprint Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats
    Zachary A Rodd
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202 4887, United States
    Pharmacol Biochem Behav 89:481-98. 2008
    ..g., Cav2, Nrxn3, Gabrb2, Gad1, Homer1) and homeostasis (S100b, Prkca, Ftl1) categories. Overall, the results suggest that changes in gene expression in the ACB of iP rats are associated with the reinforcing effects of EtOH...
  11. ncbi request reprint Intracranial self-administration of cocaine within the posterior ventral tegmental area of Wistar rats: evidence for involvement of serotonin-3 receptors and dopamine neurons
    Zachary A Rodd
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, 791 Union Drive, Indianapolis, IN 46202 4887, USA
    J Pharmacol Exp Ther 313:134-45. 2005
    ....
  12. pmc Factors mediating alcohol craving and relapse: stress, compulsivity, and genetics
    Zachary A Rodd
    Institute of Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, 46202 4887, USA
    Alcohol Clin Exp Res 29:1325-33. 2005
  13. ncbi request reprint Chronic ethanol drinking by alcohol-preferring rats increases the sensitivity of the posterior ventral tegmental area to the reinforcing effects of ethanol
    Zachary A Rodd
    Institute of Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, Indiana University, 791 Union Drive, Indianapolis, IN 46202, USA
    Alcohol Clin Exp Res 29:358-66. 2005
    ..The objective of this study was to test the hypothesis that chronic ethanol drinking increases the sensitivity of the posterior VTA to the reinforcing effects of ethanol...
  14. ncbi request reprint The reinforcing properties of salsolinol in the ventral tegmental area: evidence for regional heterogeneity and the involvement of serotonin and dopamine
    Zachary A Rodd
    Institute of Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46202 4887, USA
    Alcohol Clin Exp Res 32:230-9. 2008
    ..The current study examined SAL self-infusions into the VTA, and determined the involvement of dopamine neurons and 5-HT3 receptors in this process...
  15. pmc The reinforcing actions of a serotonin-3 receptor agonist within the ventral tegmental area: evidence for subregional and genetic differences and involvement of dopamine neurons
    Zachary A Rodd
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, 791 Union Drive, Indianapolis, IN 46202 4887, USA
    J Pharmacol Exp Ther 321:1003-12. 2007
    ..Furthermore, the data suggest that selective breeding for alcohol-preference results in the posterior VTA being more sensitive to the reinforcing effects of CPBG...
  16. ncbi request reprint The metabotropic glutamate 2/3 receptor agonist LY404039 reduces alcohol-seeking but not alcohol self-administration in alcohol-preferring (P) rats
    Zachary A Rodd
    Department of Psychiatry, Indiana University School of Medicine, Institute of Psychiatric Research, Indianapolis, 46202 4887, USA
    Behav Brain Res 171:207-15. 2006
    ..The results of this study demonstrate that activating mGlu2/3 receptors inhibits the expression of alcohol seeking and relapse behavior without altering alcohol self-administration behavior...
  17. doi request reprint Serotonin-3 receptors in the posterior ventral tegmental area regulate ethanol self-administration of alcohol-preferring (P) rats
    Zachary A Rodd
    Department of Psychiatry, Institute of Psychiatric Research, Indiana School of Medicine, Indianapolis, USA
    Alcohol 44:245-55. 2010
    ..In addition, chronic operant ethanol self-administration and/or repeated treatments with a 5-HT(3) receptor antagonist may alter neuronal circuitry within the posterior VTA...
  18. ncbi request reprint Low-dose stimulatory effects of ethanol during adolescence in rat lines selectively bred for high alcohol intake
    Z A Rodd
    Department of Psychiatry and Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202 4887, USA
    Alcohol Clin Exp Res 28:535-43. 2004
    ....
  19. ncbi request reprint Intracranial self-administration of ethanol within the ventral tegmental area of male Wistar rats: evidence for involvement of dopamine neurons
    Zachary A Rodd
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Neurosci 24:1050-7. 2004
    ..The results of this study indicate that EtOH is reinforcing within the posterior VTA of male Wistar rats and suggest that activation of VTA DA neurons is involved in this process...
  20. ncbi request reprint Effects of 5-HT(3) receptor antagonists on daily alcohol intake under acquisition, maintenance, and relapse conditions in alcohol-preferring (P) rats
    Z A Rodd-Henricks
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis 46202 4887, USA
    Alcohol 21:73-85. 2000
    ....
  21. ncbi request reprint Effects of ethanol exposure on subsequent acquisition and extinction of ethanol self-administration and expression of alcohol-seeking behavior in adult alcohol-preferring (P) rats: I. Periadolescent exposure
    Zachary A Rodd-Henricks
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis 46202 4887, USA
    Alcohol Clin Exp Res 26:1632-41. 2002
    ....
  22. ncbi request reprint Effects of ethanol exposure on subsequent acquisition and extinction of ethanol self-administration and expression of alcohol-seeking behavior in adult alcohol-preferring (P) rats: II. Adult exposure
    Zachary A Rodd-Henricks
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis 46202 4887, USA
    Alcohol Clin Exp Res 26:1642-52. 2002
    ..The objective of the present study was to determine if EtOH consumption during adulthood produced similar effects on subsequent operant behaviors...
  23. ncbi request reprint Cocaine is self-administered into the shell but not the core of the nucleus accumbens of Wistar rats
    Zachary A Rodd-Henricks
    Institute of Psychiatric Research and Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46202 4887, USA
    J Pharmacol Exp Ther 303:1216-26. 2002
    ..These findings suggest that the AcbSh is a neuroanatomical substrate for the reinforcing effects of cocaine and that activation of D2-like receptors is involved...
  24. ncbi request reprint Effects of serotonin-3 receptor antagonists on the intracranial self-administration of ethanol within the ventral tegmental area of Wistar rats
    Zachary A Rodd-Henricks
    Department of Psychiatry, Institute of Psychiatric Research, Indiana School of Medicine, 791 Union Drive, Indianapolis, IN 46202 4887, USA
    Psychopharmacology (Berl) 165:252-9. 2003
    ....
  25. ncbi request reprint Salsolinol produces reinforcing effects in the nucleus accumbens shell of alcohol-preferring (P) rats
    Zachary A Rodd
    Indiana University School of Medicine, Institute of Psychiatric Research, 791 Union Drive, Indianapolis, IN 46202 4887, USA
    Alcohol Clin Exp Res 27:440-9. 2003
    ....
  26. ncbi request reprint Effects of repeated alcohol deprivations on operant ethanol self-administration by alcohol-preferring (P) rats
    Zachary A Rodd
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Neuropsychopharmacology 28:1614-21. 2003
    ..The results suggest that repeated cycles of alcohol deprivation and alcohol access increased the reinforcing effects of ETOH in the P rats...
  27. ncbi request reprint Protein expression changes in the nucleus accumbens and amygdala of inbred alcohol-preferring rats given either continuous or scheduled access to ethanol
    R L Bell
    Institute of Psychiatric Research and Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Alcohol 40:3-17. 2006
    ..This may reflect differences in neuroanatomical and/or functional characteristics associated with EtOH self-administration and possibly withdrawal, between these two brain structures...
  28. ncbi request reprint Ethanol drinking and deprivation alter dopaminergic and serotonergic function in the nucleus accumbens of alcohol-preferring rats
    R J Thielen
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University Medical Center, 791 Union Drive, Indianapolis, IN 46202 4887, USA
    J Pharmacol Exp Ther 309:216-25. 2004
    ....
  29. doi request reprint Effects of alcohol and saccharin deprivations on concurrent ethanol and saccharin operant self-administration by alcohol-preferring (P) rats
    Jamie E Toalston
    Department of Psychology, Purdue School of Science, Indiana University Purdue University at Indianapolis, Indianapolis, IN 46202, USA
    Alcohol 42:277-84. 2008
    ..Depriving P rats of both ethanol and SACC had the most pronounced effect on the magnitude and duration of the ADE, suggesting that there may be some interactions between ethanol and SACC in their CNS reinforcing effects...
  30. ncbi request reprint Candidate genes, pathways and mechanisms for alcoholism: an expanded convergent functional genomics approach
    Z A Rodd
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Pharmacogenomics J 7:222-56. 2007
    ..In conjunction with a higher reactivity to its rewarding effects, they may able to ingest enough of this nonspecific drug for a strong hedonic and addictive effect to occur...
  31. ncbi request reprint Dopamine receptor regulation of ethanol intake and extracellular dopamine levels in the ventral pallidum of alcohol preferring (P) rats
    Roberto I Melendez
    Program in Psychobiology of Addictions, Department of Psychology, LD 124, Purdue School of Science, Indiana University Purdue University at Indianapolis, IUPUI, 402 N Blackford St, Indianapolis, IN 46202 3275, USA
    Drug Alcohol Depend 77:293-301. 2005
    ....
  32. doi request reprint Phenomic, convergent functional genomic, and biomarker studies in a stress-reactive genetic animal model of bipolar disorder and co-morbid alcoholism
    H Le-Niculescu
    Laboratory of Neurophenomics, Indiana University School of Medicine, Indianapolis, Indiana
    Am J Med Genet B Neuropsychiatr Genet 147:134-66. 2008
    ..CFG analysis of the gene expression changes identified a series of novel candidate genes and blood biomarkers for bipolar disorder, alcoholism, and stress reactivity...
  33. pmc Activation of serotonin-3 receptors increases dopamine release within the ventral tegmental area of Wistar and alcohol-preferring (P) rats
    Wen Liu
    Institute of Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Alcohol 40:167-76. 2006
    ....
  34. ncbi request reprint Amphetamine-modified acoustic startle responding and prepulse inhibition in adult and adolescent alcohol-preferring and -nonpreferring rats
    R L Bell
    Institute of Psychiatric Research, Indiana University School of Medicine, 791 Union Drive, Indianapolis, IN 46202 4887, USA
    Pharmacol Biochem Behav 75:163-71. 2003
    ....
  35. ncbi request reprint Effects of ethanol drinking on central nervous system functional activity of alcohol-preferring rats
    Helen J K Sable
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Alcohol 35:129-35. 2005
    ..Overall, the results of this study indicate that 24-h ethanol-drinking experience has little effect on CNS functional neuronal activity in P rats...
  36. ncbi request reprint Adolescent alcohol drinking and its long-range consequences. Studies with animal models
    William J McBride
    Indiana University School of Medicine, Institute of Psychiatric Research, Indianapolis, Indiana 46202 4887, USA
    Recent Dev Alcohol 17:123-42. 2005
    ..With suitable animal models, a better understanding of the mechanisms underlying adolescent alcohol drinking and its long-range consequences can be attained...
  37. ncbi request reprint Effects of multiple alcohol deprivations on operant ethanol self-administration by high-alcohol-drinking replicate rat lines
    Scott M Oster
    Department of Psychology, Purdue School of Science, Indiana University Purdue University at Indianapolis, Indianapolis, IN 46202, USA
    Alcohol 38:155-64. 2006
    ....
  38. pmc The role of 5-HT3 receptors in drug abuse and as a target for pharmacotherapy
    E A Engleman
    Indiana University School of Medicine, Department of Psychiatry, Institute of Psychiatric Research, 791 Union Drive, Indianapolis, IN 46202, USA
    CNS Neurol Disord Drug Targets 7:454-67. 2008
    ....
  39. pmc Convergent functional genomic studies of ω-3 fatty acids in stress reactivity, bipolar disorder and alcoholism
    H Le-Niculescu
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Transl Psychiatry 1:e4. 2011
    ..In conclusion, our work supports the potential utility of omega-3 fatty acids, specifically DHA, for a spectrum of psychiatric disorders such as stress disorders, bipolar disorder, alcoholism and beyond...
  40. ncbi request reprint The alcohol-preferring P rat and animal models of excessive alcohol drinking
    Richard L Bell
    Department of Psychiatry, Indiana University School of Medicine, USA
    Addict Biol 11:270-88. 2006
    ....
  41. pmc Involvement of local serotonin-2A but not serotonin-1B receptors in the reinforcing effects of ethanol within the posterior ventral tegmental area of female Wistar rats
    Zheng Ming Ding
    Graduate Program in Medical Neuroscience, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Psychopharmacology (Berl) 204:381-90. 2009
    ..5-HT(1B) and 5-HT(2A) receptors are involved in the effects of 5-HT and ethanol on VTA dopamine neurons...
  42. pmc Differential effects of dopamine D2 and GABA(A) receptor antagonists on dopamine neurons between the anterior and posterior ventral tegmental area of female Wistar rats
    Zheng Ming Ding
    Indiana University School of Medicine, Institute of PsychiatricResearch, 791 Union Drive, Indianapolis, IN 46202 4887, USA
    Pharmacol Biochem Behav 92:404-12. 2009
    ....
  43. pmc Sensitization of ventral tegmental area dopamine neurons to the stimulating effects of ethanol
    Zheng Ming Ding
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, IN 46202 4887, USA
    Alcohol Clin Exp Res 33:1571-81. 2009
    ..The current study tested the hypothesis that local exposure of the p-VTA to ethanol would increase the sensitivity of dopamine (DA) neurons to the stimulating effects of ethanol...
  44. pmc Gene expression changes in the nucleus accumbens of alcohol-preferring rats following chronic ethanol consumption
    Richard L Bell
    Department of Psychiatry, Indiana University Purdue University at Indianapolis, Indianapolis, IN 46202, USA
    Pharmacol Biochem Behav 94:131-47. 2009
    ..Conversely, chronic MSA drinking, with its associated protracted withdrawal periods, results in genomic changes that may be masked by tight regulation of these genes following repeated experiences of ethanol withdrawal...
  45. pmc Ethanol is self-administered into the nucleus accumbens shell, but not the core: evidence of genetic sensitivity
    Eric A Engleman
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indiana University Purdue University at Indianapolis, 791 Union Drive, Indianapolis, IN 46202 4887, USA
    Alcohol Clin Exp Res 33:2162-71. 2009
    ....
  46. pmc The posterior ventral tegmental area mediates alcohol-seeking behavior in alcohol-preferring rats
    Sheketha R Hauser
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, IN, USA
    J Pharmacol Exp Ther 336:857-65. 2011
    ..Overall, the results suggest that the p-VTA is a neuroanatomical substrate mediating alcohol-seeking behavior and that activation of local DA neurons is involved...
  47. ncbi request reprint Effects of concurrent access to a single concentration or multiple concentrations of ethanol on ethanol intake by periadolescent high-alcohol-drinking rats
    Richard L Bell
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Alcohol 33:107-15. 2004
    ....
  48. pmc Autonomic activation associated with ethanol self-administration in adult female P rats
    Richard L Bell
    Institute of Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Pharmacol Biochem Behav 91:223-32. 2008
    ..Therefore, this behavioral test may prove advantageous in screening pharmacotherapies for reducing craving and relapse, which are associated with cue-reactivity in abstinent alcoholics...
  49. pmc Effects of short deprivation and re-exposure intervals on the ethanol drinking behavior of selectively bred high alcohol-consuming rats
    Richard L Bell
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Alcohol 42:407-16. 2008
    ..These findings suggest that (a) an ADE may be observed with short ethanol deprivation and re-exposure intervals in HAD rats, and (b) the genetic make-up of the P and HAD rats influences the expression of this ADE...
  50. ncbi request reprint Daily patterns of ethanol drinking in peri-adolescent and adult alcohol-preferring (P) rats
    Richard L Bell
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Pharmacol Biochem Behav 83:35-46. 2006
    ..This suggests that the effectiveness of treatments for reducing excessive alcohol intake may vary depending upon the age and/or sex of the subjects being tested...
  51. pmc Chronic ethanol consumption increases dopamine uptake in the nucleus accumbens of high alcohol drinking rats
    Michelle R Carroll
    Program in Psychobiology of Addictions, Department of Psychology, Purdue School of Science, Indianapolis, IN 46202, USA
    Alcohol 40:103-9. 2006
    ..Overall, the data indicate that chronic ethanol consumption by HAD-1 rats produces prolonged neuroadaptations within the mesolimbic DA system, which may be important for the understanding of the neurobiological basis of alcoholism...
  52. pmc Differential effects of ethanol in the nucleus accumbens shell of alcohol-preferring (P), alcohol-non-preferring (NP) and Wistar rats: a proteomics study
    William J McBride
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, United States
    Pharmacol Biochem Behav 92:304-13. 2009
    ....
  53. pmc Prolonged increase in the sensitivity of the posterior ventral tegmental area to the reinforcing effects of ethanol following repeated exposure to cycles of ethanol access and deprivation
    Zachary A Rodd
    Institute of Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, 46202, USA
    J Pharmacol Exp Ther 315:648-57. 2005
    ..Chronic alcohol drinking by P rats increased the reinforcing effects of ethanol within the posterior VTA, and repeated alcohol deprivations produced a further increase in these reinforcing effects of ethanol...
  54. ncbi request reprint Effects of long-term episodic access to ethanol on the expression of an alcohol deprivation effect in low alcohol-consuming rats
    Richard L Bell
    Indiana University School of Medicine, Department of Psychiatry, Institute of Psychiatric Research, 791 Union Drive, Indianapolis, IN 46202 4887, USA
    Alcohol Clin Exp Res 28:1867-74. 2004
    ..In addition, both P and HAD rats display an alcohol deprivation effect (ADE). This study was undertaken to test whether the NP, LAD-1, and LAD-2 lines of rats could display an ADE as well...
  55. ncbi request reprint Involvement of the mesopallidal dopamine system in ethanol reinforcement
    Roberto I Melendez
    Department of Psychology, Purdue School of Science, Indiana University Purdue University at Indianapolis, Indianapolis, IN 46202, USA
    Alcohol 32:137-44. 2004
    ....
  56. ncbi request reprint Effects of naltrexone on the acquisition of alcohol intake in male and female periadolescent and adult alcohol-preferring (P) rats
    Helen J K Sable
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Int J Adolesc Med Health 18:139-49. 2006
    ..Therefore, NTX may serve as an effective treatment in reducing alcohol abuse and dependence in genetically, and perhaps environmentally, at-risk youth...
  57. ncbi request reprint The role of acetaldehyde in the central effects of ethanol
    Etienne Quertemont
    Neuroscience Comportementale et Psychopharmacologie, University of Liege, Liege, Belgium
    Alcohol Clin Exp Res 29:221-34. 2005
    ..McBride, Zachary A. Rodd, Avram Goldstein, Alejandro Zaffaroni and Ting-Kai Li; and (5) Acetaldehyde increases dopaminergic transmission in the limbic system, by Milena Pisano and Marco Diana...
  58. ncbi request reprint Adolescent vulnerabilities to chronic alcohol or nicotine exposure: findings from rodent models
    Susan Barron
    Psychology Department, University of Kentucky, Lexington, KY 40506 0044, USA
    Alcohol Clin Exp Res 29:1720-5. 2005
    ..Finally, Linda Spear provided some summary points and recommendations regarding unresolved issues and future directions...
  59. ncbi request reprint Is ethanol a pro-drug? Acetaldehyde contribution to brain ethanol effects
    Etienne Quertemont
    Neuroscience Comportementale et Psychopharmacologie, University of Liege, Belgium
    Alcohol Clin Exp Res 29:1514-21. 2005
    ..Rodd and Richard R. Bell; (4) Molecular and biochemical changes associated with acetaldehyde in human alcoholism and alcohol abuse, by C. J. Peter Eriksson...

Research Grants1

  1. Gene expression associated with the CNS reinforcing act*
    ZACHARY RODD HENRICKS; Fiscal Year: 2003
    ..The results of the proposed project will provide valuable information on neuronal systems and receptors within the extended amygdala involved in mediating the rewarding properties of alcohol. ..