Peter Roach

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. doi request reprint Glycogen and its metabolism: some new developments and old themes
    Peter J Roach
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Biochem J 441:763-87. 2012
  2. doi request reprint Are there errors in glycogen biosynthesis and is laforin a repair enzyme?
    Peter J Roach
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indiana, USA
    FEBS Lett 585:3216-8. 2011
  3. ncbi request reprint Glycogen and its metabolism
    Peter J Roach
    Department of Biochemistry and Molecular Biology, and Center for Diabetes Research, Indiana University School of Medicine, IUPUI, Indianapolis 46202, USA
    Curr Mol Med 2:101-20. 2002
  4. ncbi request reprint Crystal structure of the autocatalytic initiator of glycogen biosynthesis, glycogenin
    Brian J Gibbons
    Department of Biochemistry and Molecular Biology and Center for Diabetes Research, Indiana University School of Medicine, 635 Barnhill Drive Indianapolis, IN 46202 5122, USA
    J Mol Biol 319:463-77. 2002
  5. ncbi request reprint GNIP, a novel protein that binds and activates glycogenin, the self-glucosylating initiator of glycogen biosynthesis
    Alexander V Skurat
    Department of Biochemistry and Molecular Biology and Center for Diabetes Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 277:19331-8. 2002
  6. pmc Structural basis for glucose-6-phosphate activation of glycogen synthase
    Sulochanadevi Baskaran
    Department of Biochemistry and Molelcular Biology, Indiana University School of Medicine, Indianapolis, IN 46202 5122, USA
    Proc Natl Acad Sci U S A 107:17563-8. 2010
  7. ncbi request reprint Exercise capacity of mice genetically lacking muscle glycogen synthase: in mice, muscle glycogen is not essential for exercise
    Bartholomew A Pederson
    Department of Biochemistry and Molecular Biology and Indiana University Center for Diabetes Research, Indiana University School of Medicine, Indianapolis, Indiana 46202 5122, USA
    J Biol Chem 280:17260-5. 2005
  8. ncbi request reprint Regulation of yeast glycogen phosphorylase by the cyclin-dependent protein kinase Pho85p
    Wayne A Wilson
    Department of Biochemistry and Molecular Biology, Center for Diabetes Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Biochem Biophys Res Commun 329:161-7. 2005
  9. pmc Requirements for catalysis in mammalian glycogenin
    Thomas D Hurley
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202 5122, USA
    J Biol Chem 280:23892-9. 2005
  10. pmc Direct detection of glycogenin reaction products during glycogen initiation
    Thomas D Hurley
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202 5122, USA
    Biochem Biophys Res Commun 348:374-8. 2006

Research Grants

  1. Glycogen Metabolism and Lafora Disease
    Peter Roach; Fiscal Year: 2009
  2. HORMONAL CONTROL OF GLYCOGEN METABOLISM
    Peter Roach; Fiscal Year: 2004
  3. GLYCOGEN METABOLISM AND SIGNAL TRANSDUCTION IN YEAST
    Peter Roach; Fiscal Year: 2005
  4. Glycogen metabolism and its regulation
    Peter Roach; Fiscal Year: 2007
  5. RESEARCH TRAINING PROGRAM IN DIABETES AND OBESITY
    Peter Roach; Fiscal Year: 2007
  6. Glycogen Metabolism and Lafora Disease
    Peter J Roach; Fiscal Year: 2010
  7. GLYCOGEN METABOLISM AND SIGNAL TRANSDUCTION IN YEAST
    Peter Roach; Fiscal Year: 1999
  8. HORMONAL CONTROL OF GLYCOGEN METABOLISM
    Peter Roach; Fiscal Year: 1991
  9. GLYCOGEN METABOLISM AND SIGNAL TRANSDUCTION IN YEAST
    Peter Roach; Fiscal Year: 1993

Collaborators

  • Alexander V Skurat
  • Wayne A Wilson
  • Wei Wang
  • Thomas Hurley
  • Anna A Depaoli-Roach
  • J Zhou
  • Owen McGuinness
  • Antonio V Delgado-Escueta
  • ROBERT ADRON HARRIS
  • Nina Raben
  • Fredrik Karpe
  • Jared Rutter
  • Bartholomew A Pederson
  • Vincent S Tagliabracci
  • Lanmin Zhai
  • Jose M Irimia
  • Jill M Schroeder
  • Gretchen E Parker
  • Sixin Jiang
  • Sulochanadevi Baskaran
  • Candy A Heyen
  • Cheryl B Bock
  • David B Savage
  • Xiaochu Zhao
  • Julie Turnbull
  • Jean Marie Girard
  • Berge A Minassian
  • Beth L Thurberg
  • Renato M de Paula
  • Carlie R Cope
  • Micah W Smith
  • María Jesús Torija
  • Maria Célia Bertolini
  • Renato Magalhães de Paula
  • Isao Hanashiro
  • Brian J Gibbons
  • Caron L Peper
  • Stephen F Previs
  • Brigitte Heller
  • Clark D Wells
  • Catalina M Meyer
  • Bhavana Solanky
  • Sung Eun Wou
  • Nicholas J Wareham
  • Antonio Vidal-Puig
  • Gerald I Shulman
  • Dyann Segvich
  • Balasubramanian Ravikumar
  • Roy Taylor
  • Johanna E Snaar
  • Dinesh Deelchand
  • Sheene Kim
  • Cheol Soo Choi
  • Amanda C McGuire
  • Gemma Medina-Gomez
  • Dyann M Segvich
  • Catalina Meyer
  • Stephen O'Rahilly
  • Mariko Obayashi
  • Anne Lemassu
  • Jean Francois
  • Hector Francisco Terenzi
  • Jean Luc Parrou
  • Maite Novo
  • Héctor F Terenzi
  • Weinian Shou
  • Amy Dietrich
  • Hanying Chen
  • Renee Simon
  • Anna G Csitkovits

Detail Information

Publications39

  1. doi request reprint Glycogen and its metabolism: some new developments and old themes
    Peter J Roach
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Biochem J 441:763-87. 2012
    ....
  2. doi request reprint Are there errors in glycogen biosynthesis and is laforin a repair enzyme?
    Peter J Roach
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indiana, USA
    FEBS Lett 585:3216-8. 2011
    ..The hypothesis is that glycogen phosphorylation can be considered a catalytic error and laforin a repair enzyme...
  3. ncbi request reprint Glycogen and its metabolism
    Peter J Roach
    Department of Biochemistry and Molecular Biology, and Center for Diabetes Research, Indiana University School of Medicine, IUPUI, Indianapolis 46202, USA
    Curr Mol Med 2:101-20. 2002
    ..Defects in the basic metabolizing enzymes lead to severe consequences whereas, with some exceptions, mutations in the regulatory proteins appear to cause a more subtle phenotypic change...
  4. ncbi request reprint Crystal structure of the autocatalytic initiator of glycogen biosynthesis, glycogenin
    Brian J Gibbons
    Department of Biochemistry and Molecular Biology and Center for Diabetes Research, Indiana University School of Medicine, 635 Barnhill Drive Indianapolis, IN 46202 5122, USA
    J Mol Biol 319:463-77. 2002
    ..Possibly the initial glucosylation is via inter-dimeric catalysis with an intra-molecular mechanism employed later in oligosaccharide synthesis...
  5. ncbi request reprint GNIP, a novel protein that binds and activates glycogenin, the self-glucosylating initiator of glycogen biosynthesis
    Alexander V Skurat
    Department of Biochemistry and Molecular Biology and Center for Diabetes Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 277:19331-8. 2002
    ..GNIPs may represent a novel participant in the initiation of glycogen synthesis...
  6. pmc Structural basis for glucose-6-phosphate activation of glycogen synthase
    Sulochanadevi Baskaran
    Department of Biochemistry and Molelcular Biology, Indiana University School of Medicine, Indianapolis, IN 46202 5122, USA
    Proc Natl Acad Sci U S A 107:17563-8. 2010
    ....
  7. ncbi request reprint Exercise capacity of mice genetically lacking muscle glycogen synthase: in mice, muscle glycogen is not essential for exercise
    Bartholomew A Pederson
    Department of Biochemistry and Molecular Biology and Indiana University Center for Diabetes Research, Indiana University School of Medicine, Indianapolis, Indiana 46202 5122, USA
    J Biol Chem 280:17260-5. 2005
    ..These studies provide genetic evidence that in mice muscle glycogen is not essential for strenuous exercise and has relatively little effect on endurance...
  8. ncbi request reprint Regulation of yeast glycogen phosphorylase by the cyclin-dependent protein kinase Pho85p
    Wayne A Wilson
    Department of Biochemistry and Molecular Biology, Center for Diabetes Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Biochem Biophys Res Commun 329:161-7. 2005
    ..Here, we show that the cyclin-dependent protein kinase, Pho85p, which we have previously found to regulate glycogen synthase also controls the phosphorylation state of phosphorylase...
  9. pmc Requirements for catalysis in mammalian glycogenin
    Thomas D Hurley
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202 5122, USA
    J Biol Chem 280:23892-9. 2005
    ..These data support a role for aspartate 162 in the chemical step for the glucosyltransferase reaction and a role for aspartate 159 in binding and activating the acceptor molecule...
  10. pmc Direct detection of glycogenin reaction products during glycogen initiation
    Thomas D Hurley
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202 5122, USA
    Biochem Biophys Res Commun 348:374-8. 2006
    ..The results from this assay provide new insight into the mechanism by which glycogenin catalyzes the initiation reaction...
  11. pmc Interaction between glycogenin and glycogen synthase
    Alexander V Skurat
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202 5122, USA
    Arch Biochem Biophys 456:93-7. 2006
    ..We demonstrate that the COOH-terminal fragment of glycogenin can be used as an effective high affinity reagent for the purification of glycogen synthase from skeletal muscle and liver...
  12. pmc Genetic depletion of the malin E3 ubiquitin ligase in mice leads to lafora bodies and the accumulation of insoluble laforin
    Anna A Depaoli-Roach
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202 5122, USA
    J Biol Chem 285:25372-81. 2010
    ....
  13. ncbi request reprint Glycogen and related polysaccharides inhibit the laforin dual-specificity protein phosphatase
    Wei Wang
    Department of Biochemistry and Molecular Biology, Center for Diabetes Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Biochem Biophys Res Commun 325:726-30. 2004
    ....
  14. pmc Abnormal cardiac development in the absence of heart glycogen
    Bartholomew A Pederson
    Department of Biochemistry and Molecular Biology, School of Medicine, Indiana University, Indianapolis, IN 46202 5122, USA
    Mol Cell Biol 24:7179-87. 2004
    ....
  15. ncbi request reprint Saccharomyces gene deletion project: applications and use in the study of protein kinases and phosphatases
    Wayne A Wilson
    Department of Biochemistry and Molecular Biology, Center for Diabetes Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Methods Enzymol 366:403-18. 2003
  16. ncbi request reprint Analysis of respiratory mutants reveals new aspects of the control of glycogen accumulation by the cyclin-dependent protein kinase Pho85p
    Wayne A Wilson
    Department of Biochemistry, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202 5122, USA
    FEBS Lett 515:104-8. 2002
    ..This suggested the existence of inputs from Pho85p into glycogen storage, independent of Pcl8p and Pcl10p, and acting antagonistically...
  17. ncbi request reprint Overexpression of glycogen synthase in mouse muscle results in less branched glycogen
    Bartholomew A Pederson
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, and Indiana University Center for Diabetes Research, Indianapolis, IN 46202 5122, USA
    Biochem Biophys Res Commun 305:826-30. 2003
    ..However, this compared with an increase in glycogen synthase of some 50-fold, so that the increase in branching enzyme in response to overexpression of glycogen synthase was insufficient to synthesize normally branched glycogen...
  18. pmc Glycogen metabolism in tissues from a mouse model of Lafora disease
    Wei Wang
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202 5122, USA
    Arch Biochem Biophys 457:264-9. 2007
    ....
  19. pmc Laforin is a glycogen phosphatase, deficiency of which leads to elevated phosphorylation of glycogen in vivo
    Vincent S Tagliabracci
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Proc Natl Acad Sci U S A 104:19262-6. 2007
    ..This study provides a molecular link between an observed biochemical property of laforin and the phenotype of a mouse model of Lafora disease. The results also have important implications for glycogen metabolism generally...
  20. ncbi request reprint Mutations of muscle glycogen synthase that disable activation by glucose 6-phosphate
    Isao Hanashiro
    Department of Biochemistry and Molecular Biology and Center for Diabetes Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Arch Biochem Biophys 397:286-92. 2002
    ..However, the role must differ subtly between the mammalian and the yeast enzymes...
  21. ncbi request reprint Nutrient-regulated protein kinases in budding yeast
    Wayne A Wilson
    Department of Biochemistry and Molecular Biology, Center for Diabetes Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Cell 111:155-8. 2002
    ..A recently characterized enzyme, PAS kinase, may be a new member of this group of nutritional transducers...
  22. ncbi request reprint Glycogen synthase sensitivity to glucose-6-P is important for controlling glycogen accumulation in Saccharomyces cerevisiae
    Bartholomew A Pederson
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine and the Indiana University Center for Diabetes Research, Indianapolis, Indiana 46202, USA
    J Biol Chem 279:13764-8. 2004
    ..This is the first direct demonstration that activation of glycogen synthase by glucose-6-P in vivo is necessary for normal glycogen accumulation...
  23. ncbi request reprint Systematic identification of the genes affecting glycogen storage in the yeast Saccharomyces cerevisiae: implication of the vacuole as a determinant of glycogen level
    Wayne A Wilson
    Department of Biochemistry and Molecular Biology and Center for Diabetes Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Mol Cell Proteomics 1:232-42. 2002
    ..21, 5742-5752). Autophagy delivers glycogen to the vacuole, and we propose that the impaired vacuolar function associated with ATPase mutants (vma10 or vma22) results in reduced degradation and subsequent hyperaccumulation of glycogen...
  24. pmc Relationship between glycogen accumulation and the laforin dual specificity phosphatase
    Wei Wang
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202 5122, USA
    Biochem Biophys Res Commun 350:588-92. 2006
    ..We propose, therefore, that laforin senses cytosolic glycogen accumulation which in turn determines the level of laforin protein...
  25. pmc Gene expression profiling of mice with genetically modified muscle glycogen content
    Gretchen E Parker
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202 5122, USA
    Biochem J 395:137-45. 2006
    ..Particularly interesting is the observation that 11 of these genes encode cardiac or slow-twitch isoforms of muscle contractile proteins, and are upregulated in muscle that has a greater oxidative capacity in MGSKO mice...
  26. ncbi request reprint Glucose metabolism in mice lacking muscle glycogen synthase
    Bartholomew A Pederson
    Department of Biochemistry and Molecular Biology and Center for Diabetes Research, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Diabetes 54:3466-73. 2005
    ..Although disruption of the GYS1 gene negatively affects muscle glucose uptake, overall glucose tolerance is actually improved, possibly because of a role for GYS1 in tissues other than muscle...
  27. ncbi request reprint Structure-function analysis of GNIP, the glycogenin-interacting protein
    Lanmin Zhai
    Department of Biochemistry and Molecular Biology, Center for Diabetes Research, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202 5122, USA
    Arch Biochem Biophys 421:236-42. 2004
    ..Heterologous interactions between GNIP1 and GNIP2 were also detected. Since glycogenin is also a dimer, higher order multimeric complexes between glycogenin and GNIPs would be possible...
  28. ncbi request reprint Mice with elevated muscle glycogen stores do not have improved exercise performance
    Bartholomew A Pederson
    Department of Biochemistry and Molecular Biology and Center for Diabetes Research, Indiana University School of Medicine, Indianapolis, IN 46202 5122, USA
    Biochem Biophys Res Commun 331:491-6. 2005
    ..This result suggests that increased muscle glycogen stores do not necessarily improve exercise performance in mice...
  29. ncbi request reprint Determination of mammalian glycogen synthase phosphatase activity
    Anna A Depaoli-Roach
    Department of Biochemistry and Molecular Biology, Center for Diabetes Research, Indiana University School of Medicine, 635 Barnhill Dr, Indianapolis, Indiana 46202, USA
    Methods Enzymol 366:17-34. 2003
  30. pmc Starch binding domain-containing protein 1/genethonin 1 is a novel participant in glycogen metabolism
    Sixin Jiang
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 285:34960-71. 2010
    ..We conclude that Stbd1 is involved in glycogen metabolism by binding to glycogen and anchoring it to membranes, thereby affecting its cellular localization and its intracellular trafficking to lysosomes...
  31. pmc Impaired glucose tolerance and predisposition to the fasted state in liver glycogen synthase knock-out mice
    Jose M Irimia
    Department of Biochemistry and Molecular Biology, Center for Diabetes Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 285:12851-61. 2010
    ..This mouse model mimics the pathophysiology of glycogen storage disease 0 patients and highlights the importance of liver glycogen stores in whole body glucose homeostasis...
  32. pmc Characterization of mouse UDP-glucose pyrophosphatase, a Nudix hydrolase encoded by the Nudt14 gene
    Candy A Heyen
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Biochem Biophys Res Commun 390:1414-8. 2009
    ..Sequence alignments and database searches revealed related proteins in species as distant as Drosophila melanogaster and Caenorhabditis elegans...
  33. pmc Abnormal metabolism of glycogen phosphate as a cause for Lafora disease
    Vincent S Tagliabracci
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 283:33816-25. 2008
    ..We propose that laforin functions to suppress excessive glycogen phosphorylation and is an essential component of the metabolism of normally structured glycogen...
  34. ncbi request reprint Increased glycogen storage in yeast results in less branched glycogen
    Wayne A Wilson
    Department of Biochemistry and Molecular Biology, Center for Diabetes Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Biochem Biophys Res Commun 320:416-23. 2004
    ..Whenever glycogen storage was elevated, the polysaccharide formed was found to be less branched but normal branching could be restored by overexpression of branching enzyme...
  35. pmc A prevalent variant in PPP1R3A impairs glycogen synthesis and reduces muscle glycogen content in humans and mice
    David B Savage
    Department of Clinical Biochemistry and Medicine, University of Cambridge, Cambridge, United Kingdom
    PLoS Med 5:e27. 2008
    ..However, the functional implications of the mutation were not known. The objective of this study was to characterise the molecular and physiological consequences of this genetic variant...
  36. ncbi request reprint Biochemical characterization of Neurospora crassa glycogenin (GNN), the self-glucosylating initiator of glycogen synthesis
    Renato M de Paula
    Instituto de Quimica, UNESP, Departamento de Bioquímica e Tecnologia Química, R Professor Francisco Degni, S N, 14800 900 Araraquara, SP, Brazil
    FEBS Lett 579:2208-14. 2005
    ..While the entire GSN was required for full interaction, the C-terminus in GNN was more important. Furthermore, mutation in the GNN glucosylation sites did not impair the interaction with GSN...
  37. ncbi request reprint Glycogen synthesis in the absence of glycogenin in the yeast Saccharomyces cerevisiae
    María Jesús Torija
    Centre Bioingenierie Gilbert Durand, UMR CNRS 5504, UMR INRA 792, Institut National des Sciences Appliquees, 31077 Toulouse Cedex 04, France
    FEBS Lett 579:3999-4004. 2005
    ....
  38. pmc Control of mammalian glycogen synthase by PAS kinase
    Wayne A Wilson
    Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Proc Natl Acad Sci U S A 102:16596-601. 2005
    ..This mode of regulation provides a mechanism for metabolic status to impinge directly on the cellular decision of whether to store or use available energy...
  39. ncbi request reprint GNN is a self-glucosylating protein involved in the initiation step of glycogen biosynthesis in Neurospora crassa
    Renato Magalhães de Paula
    Instituto de Quimica, UNESP, Departamento de Bioquímica e Tecnologia Química, 14800 900 Araraquara, SP, Brazil
    Arch Biochem Biophys 435:112-24. 2005
    ..Northern blot analysis showed that the gnn gene was induced during vegetative growth and was repressed upon carbon starvation...

Research Grants33

  1. Glycogen Metabolism and Lafora Disease
    Peter Roach; Fiscal Year: 2009
    ..The research proposed in this application seeks to understand what is wrong with glycogen storage in Lafora disease, which could help provide clues to new treatment regimens. ..
  2. HORMONAL CONTROL OF GLYCOGEN METABOLISM
    Peter Roach; Fiscal Year: 2004
    ..We will also attempt to assess in animal models the roles of phosphorylation and G6P activation of GS in controlling glycogen synthesis ..
  3. GLYCOGEN METABOLISM AND SIGNAL TRANSDUCTION IN YEAST
    Peter Roach; Fiscal Year: 2005
    ..Yeast has proven to be a useful experimental system to study vesicular trafficking and such may be true for the study of autophagy and its relationship to glycogen metabolism (aim iii). ..
  4. Glycogen metabolism and its regulation
    Peter Roach; Fiscal Year: 2007
    ..Its action could therefore profoundly affect glycogen metabolism. The goal of this aim is to establish whether UGPPase influences UDP-glucose and glycogen levels in vivo. ..
  5. RESEARCH TRAINING PROGRAM IN DIABETES AND OBESITY
    Peter Roach; Fiscal Year: 2007
    ..abstract_text> ..
  6. Glycogen Metabolism and Lafora Disease
    Peter J Roach; Fiscal Year: 2010
    ..The research proposed in this application seeks to understand what is wrong with glycogen storage in Lafora disease, which could help provide clues to new treatment regimens. ..
  7. GLYCOGEN METABOLISM AND SIGNAL TRANSDUCTION IN YEAST
    Peter Roach; Fiscal Year: 1999
    ..This study of yeast may help give a broader perspective on intracellular signaling that can be relevant to the control of cellular events such as growth, proliferation and metabolism, in mammalian systems. ..
  8. HORMONAL CONTROL OF GLYCOGEN METABOLISM
    Peter Roach; Fiscal Year: 1991
    ..Success would significantly extend knowledge of the mechanisms of action of several hormones, notably insulin, of obvious relevance to better understanding of situations of impaired insulin control such as in diabetes...
  9. GLYCOGEN METABOLISM AND SIGNAL TRANSDUCTION IN YEAST
    Peter Roach; Fiscal Year: 1993
    ..The research, though fundamental in nature, is relevant to situations of impaired hormonal control, such as in diabetes...