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insulin receptor substrate proteins
forkhead box protein o1
sterol regulatory element binding protein 1
Genomes and Genes
Roach P, DePaoli Roach A, Hurley T, Tagliabracci V. Glycogen and its metabolism: some new developments and old themes. Biochem J. 2012;441:763-87
Roach P. Glycogen and its metabolism. Curr Mol Med. 2002;2:101-20
..Defects in the basic metabolizing enzymes lead to severe consequences whereas, with some exceptions, mutations in the regulatory proteins appear to cause a more subtle phenotypic change. ..
Roach P. AMPK -> ULK1 -> autophagy. Mol Cell Biol. 2011;31:3082-4
Roach P. Are there errors in glycogen biosynthesis and is laforin a repair enzyme?. FEBS Lett. 2011;585:3216-8
..The hypothesis is that glycogen phosphorylation can be considered a catalytic error and laforin a repair enzyme. ..
Irimia J, Meyer C, Segvich D, Surendran S, DePaoli Roach A, Morral N,
. Lack of liver glycogen causes hepatic insulin resistance and steatosis in mice. J Biol Chem. 2017;292:10455-10464
..Our results suggest that loss of liver glycogen synthesis diverts glucose toward fat synthesis, correlating with impaired hepatic insulin signaling and glucose disposal. ..
Experts and Doctors on animals in Indianapolis, Indiana, United States
Experts and Doctors on glycogen in Indianapolis, Indiana, United States
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