Shannon L Risacher

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. pmc Neuroimaging and other biomarkers for Alzheimer's disease: the changing landscape of early detection
    Shannon L Risacher
    Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Annu Rev Clin Psychol 9:621-48. 2013
  2. pmc Influence of genetic variation on plasma protein levels in older adults using a multi-analyte panel
    Sungeun Kim
    Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA
    PLoS ONE 8:e70269. 2013
  3. pmc Amyloid pathway-based candidate gene analysis of [(11)C]PiB-PET in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort
    Shanker Swaminathan
    Department of Radiology and Imaging Sciences, Center for Neuroimaging, Indiana University School of Medicine, Indianapolis, IN, USA
    Brain Imaging Behav 6:1-15. 2012
  4. pmc Altered default mode network connectivity in older adults with cognitive complaints and amnestic mild cognitive impairment
    Yang Wang
    Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Alzheimers Dis 35:751-60. 2013
  5. pmc Longitudinal MRI atrophy biomarkers: relationship to conversion in the ADNI cohort
    Shannon L Risacher
    Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University, School of Medicine, 950 W Walnut St, Indianapolis, IN 46202, United States
    Neurobiol Aging 31:1401-18. 2010
  6. pmc Comparison of manual and automated determination of hippocampal volumes in MCI and early AD
    Li Shen
    IU Center for Neuroimaging, Div of Imaging Sciences, Dept of Radiology, Indiana University School of Medicine, 950 W Walnut St, R2 E124, Indianapolis, IN 46202, USA
    Brain Imaging Behav 4:86-95. 2010
  7. pmc Whole genome association study of brain-wide imaging phenotypes for identifying quantitative trait loci in MCI and AD: A study of the ADNI cohort
    Li Shen
    Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, 950 West Walnut Street R2 E124, Indianapolis, IN 46202, USA
    Neuroimage 53:1051-63. 2010
  8. pmc The effect of reference panels and software tools on genotype imputation
    Kwangsik Nho
    Regenstrief Institute and Indiana University School of Medicine, Indianapolis, IN, USA
    AMIA Annu Symp Proc 2011:1013-8. 2011
  9. pmc Genome-wide pathway analysis of memory impairment in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort implicates gene candidates, canonical pathways, and networks
    Vijay K Ramanan
    Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA
    Brain Imaging Behav 6:634-48. 2012
  10. pmc Genomic Copy Number Analysis in Alzheimer's Disease and Mild Cognitive Impairment: An ADNI Study
    Shanker Swaminathan
    Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Int J Alzheimers Dis 2011:729478. 2011

Detail Information

Publications22

  1. pmc Neuroimaging and other biomarkers for Alzheimer's disease: the changing landscape of early detection
    Shannon L Risacher
    Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Annu Rev Clin Psychol 9:621-48. 2013
    ..We then discuss related findings in patients with dominantly inherited AD. We conclude with a discussion of the current theoretical framework for the role of biomarkers in AD and emergent directions for AD biomarker research...
  2. pmc Influence of genetic variation on plasma protein levels in older adults using a multi-analyte panel
    Sungeun Kim
    Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA
    PLoS ONE 8:e70269. 2013
    ..With intensive searches taking place for proteomic biomarkers for many diseases, the role of genetic variation takes on new importance and should be considered in interpretation of proteomic results...
  3. pmc Amyloid pathway-based candidate gene analysis of [(11)C]PiB-PET in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort
    Shanker Swaminathan
    Department of Radiology and Imaging Sciences, Center for Neuroimaging, Indiana University School of Medicine, Indianapolis, IN, USA
    Brain Imaging Behav 6:1-15. 2012
    ..Pathway-based genetic analysis of targeted molecular imaging phenotypes appears promising to help elucidate disease pathophysiology and identify potential therapeutic targets...
  4. pmc Altered default mode network connectivity in older adults with cognitive complaints and amnestic mild cognitive impairment
    Yang Wang
    Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Alzheimers Dis 35:751-60. 2013
    ..DMN connectivity appears sensitive to early prodromal neurodegenerative changes associated with AD, notably including pre-MCI individuals with cognitive complaints...
  5. pmc Longitudinal MRI atrophy biomarkers: relationship to conversion in the ADNI cohort
    Shannon L Risacher
    Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University, School of Medicine, 950 W Walnut St, Indianapolis, IN 46202, United States
    Neurobiol Aging 31:1401-18. 2010
    ..Stable MCI subjects showed intermediate atrophy rates. APOE genotype was associated with APC in key regions. In sum, APC rates are influenced by APOE genotype, imminent MCI to AD conversion, and AD-related neurodegeneration...
  6. pmc Comparison of manual and automated determination of hippocampal volumes in MCI and early AD
    Li Shen
    IU Center for Neuroimaging, Div of Imaging Sciences, Dept of Radiology, Indiana University School of Medicine, 950 W Walnut St, R2 E124, Indianapolis, IN 46202, USA
    Brain Imaging Behav 4:86-95. 2010
    ..These comparisons suggest that FreeSurfer has the potential to be used in automated determination of hippocampal volumes for large-scale MCI/AD-related MRI studies, where manual methods are inefficient or not feasible...
  7. pmc Whole genome association study of brain-wide imaging phenotypes for identifying quantitative trait loci in MCI and AD: A study of the ADNI cohort
    Li Shen
    Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, 950 West Walnut Street R2 E124, Indianapolis, IN 46202, USA
    Neuroimage 53:1051-63. 2010
    ..A genome-wide, whole brain search strategy has the potential to reveal novel candidate genes and loci warranting further investigation and replication...
  8. pmc The effect of reference panels and software tools on genotype imputation
    Kwangsik Nho
    Regenstrief Institute and Indiana University School of Medicine, Indianapolis, IN, USA
    AMIA Annu Symp Proc 2011:1013-8. 2011
    ..IMPUTE with the combined reference panel is a promising strategy for genotype imputation, which should facilitate fine-mapping for discovery as well as known disease-associated candidate regions...
  9. pmc Genome-wide pathway analysis of memory impairment in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort implicates gene candidates, canonical pathways, and networks
    Vijay K Ramanan
    Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA
    Brain Imaging Behav 6:634-48. 2012
    ....
  10. pmc Genomic Copy Number Analysis in Alzheimer's Disease and Mild Cognitive Impairment: An ADNI Study
    Shanker Swaminathan
    Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Int J Alzheimers Dis 2011:729478. 2011
    ..Replication in larger samples is important, after which regions detected here may be promising targets for resequencing...
  11. pmc Alzheimer's Disease Neuroimaging Initiative biomarkers as quantitative phenotypes: Genetics core aims, progress, and plans
    Andrew J Saykin
    Department of Radiology and Imaging Sciences, Center for Neuroimaging, Indiana University School of Medicine, Indianapolis, IN, USA
    Alzheimers Dement 6:265-73. 2010
    ..Genetic studies of longitudinal phenotypes hold promise for elucidating disease mechanisms and risk, development of therapeutic strategies, and refining selection criteria for clinical trials...
  12. pmc Association of plasma and cortical amyloid beta is modulated by APOE ε4 status
    Shanker Swaminathan
    Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA
    Alzheimers Dement 10:e9-e18. 2014
    ....
  13. pmc Sparse bayesian learning for identifying imaging biomarkers in AD prediction
    Li Shen
    Center for Neuroimaging, Department of Radiology and Imaging Sciences, USA
    Med Image Comput Comput Assist Interv 13:611-8. 2010
    ..While GLM P-map returns significant regions all over the cortex, ARD/PARD provide a small number of relevant and meaningful imaging markers with predictive power, including both cortical and subcortical measures...
  14. pmc The role of apolipoprotein E (APOE) genotype in early mild cognitive impairment (E-MCI)
    Shannon L Risacher
    Department of Radiology and Imaging Sciences, Center for Neuroimaging, Indiana University School of Medicine Indianapolis, IN, USA
    Front Aging Neurosci 5:11. 2013
    ..These findings underscore the importance of considering APOE genotype when evaluating biomarkers in early stages of disease...
  15. pmc Influence of TSPO genotype on 11C-PBR28 standardized uptake values
    Karmen K Yoder
    Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Nucl Med 54:1320-2. 2013
    ..However, it is not known whether standardized uptake value (SUV) can detect differences in brain (11)C-PBR28 uptake by TSPO genotype...
  16. pmc Genetic analysis of quantitative phenotypes in AD and MCI: imaging, cognition and biomarkers
    Li Shen
    Center for Neuroimaging and Indiana Alzheimer s Disease Center, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, 355 W 16th Street, Suite 4100, Indianapolis, IN, 46202, USA
    Brain Imaging Behav 8:183-207. 2014
    ....
  17. pmc Differences in medication use in the Alzheimer's disease neuroimaging initiative: analysis of baseline characteristics
    Noam U Epstein
    Indiana University School of Medicine, Indianapolis, 46202, USA
    Drugs Aging 27:677-86. 2010
    ..Many participants in the ADNI are being treated with medications, and these may have beneficial or deleterious effects...
  18. pmc Visual contrast sensitivity in Alzheimer's disease, mild cognitive impairment, and older adults with cognitive complaints
    Shannon L Risacher
    Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Neurobiol Aging 34:1133-44. 2013
    ..Therefore, frequency doubling technology-based measures of CS may have promise as a novel AD biomarker...
  19. pmc Voxel and surface-based topography of memory and executive deficits in mild cognitive impairment and Alzheimer's disease
    Kwangsik Nho
    Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA
    Brain Imaging Behav 6:551-67. 2012
    ..The present study provides insight into the spatially unbiased associations between brain atrophy and memory and executive function, and underscores the importance of structural brain changes in early cognitive decline...
  20. pmc Neuroimaging biomarkers of neurodegenerative diseases and dementia
    Shannon L Risacher
    Center for Neuroimaging, Department of Radiology and Imaging Sciences, and Indiana Alzheimer Disease Center Indiana University School of Medicine, Indianapolis, Indiana
    Semin Neurol 33:386-416. 2013
    ..The authors focus on neuroimaging findings of in vivo pathology in these disorders, as well as the potential for neuroimaging to provide useful information for differential diagnosis of neurodegenerative disorders. ..
  21. pmc Baseline MRI predictors of conversion from MCI to probable AD in the ADNI cohort
    Shannon L Risacher
    IU Center for Neuroimaging, Division of Imaging Sciences, Department of Radiology, Indiana University School of Medicine, 950 W Walnut St, R2 E124, Indianapolis, IN 46202, USA
    Curr Alzheimer Res 6:347-61. 2009
    ..Validation of imaging biomarkers is important as they can help enrich clinical trials of disease modifying agents by identifying individuals at highest risk for progression to AD...
  22. pmc A rat head holder for simultaneous scanning of two rats in small animal PET scanners: design, construction, feasibility testing and kinetic validation
    Tee Ean Cheng
    Biomedical Engineering Department, Purdue School of Engineering and Technology, Indianapolis, IN 46202, USA
    J Neurosci Methods 176:24-33. 2009
    ..To reduce imaging costs, we designed a head holder for scanning two rats simultaneously in small animal PET scanners. Our goals were (i) to maintain high sensitivity and (ii) to minimize repositioning error between scans...