D J Posey

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. ncbi request reprint The use of selective serotonin reuptake inhibitors in autism and related disorders
    David J Posey
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Child Adolesc Psychopharmacol 16:181-6. 2006
  2. ncbi request reprint Guanfacine treatment of hyperactivity and inattention in pervasive developmental disorders: a retrospective analysis of 80 cases
    David J Posey
    Department of Psychiatry, Indiana University School of Medicine, Riley Hospital for Children, 702 Barnhill Drive, Indianapolis, IN 46202 5200, USA
    J Child Adolesc Psychopharmacol 14:233-41. 2004
  3. ncbi request reprint Open-label atomoxetine for attention-deficit/ hyperactivity disorder symptoms associated with high-functioning pervasive developmental disorders
    David J Posey
    Department of Psychiatry and Christian Sarkine Autism Treatment Center at the Indiana University School of Medicine, Indianapolis, Indiana, USA
    J Child Adolesc Psychopharmacol 16:599-610. 2006
  4. pmc Antipsychotics in the treatment of autism
    David J Posey
    Christian Sarkine Autism Treatment Center, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Clin Invest 118:6-14. 2008
  5. ncbi request reprint Positive effects of methylphenidate on inattention and hyperactivity in pervasive developmental disorders: an analysis of secondary measures
    David J Posey
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Biol Psychiatry 61:538-44. 2007
  6. ncbi request reprint Guanfacine and guanfacine extended release: treatment for ADHD and related disorders
    David J Posey
    Christian Sarkine Autism Treatment Center, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA
    CNS Drug Rev 13:465-74. 2007
  7. ncbi request reprint Risperidone: a potential treatment for autism
    David J Posey
    Riley Hospital for Children, Indianapolis, IN 46202, USA
    Curr Opin Investig Drugs 3:1212-6. 2002
  8. pmc Developing drugs for core social and communication impairment in autism
    David J Posey
    Department of Psychiatry, Indiana University School of Medicine, 1111 West 10th Street, Indianapolis, IN 46202 4800, USA
    Child Adolesc Psychiatr Clin N Am 17:787-801, viii-ix. 2008
  9. ncbi request reprint Pharmacotherapeutic management of autism
    D J Posey
    Department of Psychiatry, Indaiana University School of Medicine, USA
    Expert Opin Pharmacother 2:587-600. 2001
  10. ncbi request reprint A retrospective analysis of quetiapine in the treatment of pervasive developmental disorders
    Adam H Corson
    Department of Psychiatry, Indiana University School of Medicine and Christian Sarkine Autism Treatment Center, James Whitcomb Riley Hospital for Children, Indianapolis, Ind 46202 4800, USA
    J Clin Psychiatry 65:1531-6. 2004

Research Grants

Detail Information

Publications45

  1. ncbi request reprint The use of selective serotonin reuptake inhibitors in autism and related disorders
    David J Posey
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Child Adolesc Psychopharmacol 16:181-6. 2006
    ..Larger, placebo-controlled studies of SSRIs are needed to guide clinical treatment...
  2. ncbi request reprint Guanfacine treatment of hyperactivity and inattention in pervasive developmental disorders: a retrospective analysis of 80 cases
    David J Posey
    Department of Psychiatry, Indiana University School of Medicine, Riley Hospital for Children, 702 Barnhill Drive, Indianapolis, IN 46202 5200, USA
    J Child Adolesc Psychopharmacol 14:233-41. 2004
    ....
  3. ncbi request reprint Open-label atomoxetine for attention-deficit/ hyperactivity disorder symptoms associated with high-functioning pervasive developmental disorders
    David J Posey
    Department of Psychiatry and Christian Sarkine Autism Treatment Center at the Indiana University School of Medicine, Indianapolis, Indiana, USA
    J Child Adolesc Psychopharmacol 16:599-610. 2006
    ..The aim of this study was to conduct an initial evaluation of the efficacy of atomoxetine for attention-deficit/hyperactivity disorder (ADHD) symptoms in children with pervasive developmental disorders (PDDs)...
  4. pmc Antipsychotics in the treatment of autism
    David J Posey
    Christian Sarkine Autism Treatment Center, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Clin Invest 118:6-14. 2008
    ..Significant adverse effects, including weight gain and the possibility of tardive dyskinesia, are reviewed. Future research directions are discussed...
  5. ncbi request reprint Positive effects of methylphenidate on inattention and hyperactivity in pervasive developmental disorders: an analysis of secondary measures
    David J Posey
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Biol Psychiatry 61:538-44. 2007
    ....
  6. ncbi request reprint Guanfacine and guanfacine extended release: treatment for ADHD and related disorders
    David J Posey
    Christian Sarkine Autism Treatment Center, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA
    CNS Drug Rev 13:465-74. 2007
    ..Adverse cardiovascular effects are uncommon, although modest reductions in blood pressure and heart rate are common. If GXR is FDA-approved, it would be the first alpha(2A) adrenoceptor agonist marketed for ADHD...
  7. ncbi request reprint Risperidone: a potential treatment for autism
    David J Posey
    Riley Hospital for Children, Indianapolis, IN 46202, USA
    Curr Opin Investig Drugs 3:1212-6. 2002
    ..Individuals with autism may also have other symptoms that become the primary focus of psychiatric treatment. These associated symptoms include aggression, self-injury, irritability and anxiety...
  8. pmc Developing drugs for core social and communication impairment in autism
    David J Posey
    Department of Psychiatry, Indiana University School of Medicine, 1111 West 10th Street, Indianapolis, IN 46202 4800, USA
    Child Adolesc Psychiatr Clin N Am 17:787-801, viii-ix. 2008
    ..More research is needed on the utility of selective serotonin reuptake inhibitors, cholinergic drugs, glutamatergic drugs, and oxytocin for core autistic symptoms...
  9. ncbi request reprint Pharmacotherapeutic management of autism
    D J Posey
    Department of Psychiatry, Indaiana University School of Medicine, USA
    Expert Opin Pharmacother 2:587-600. 2001
    ..Current pharmacological management is best aimed at target symptoms that have been demonstrated to respond to medication in treatment studies...
  10. ncbi request reprint A retrospective analysis of quetiapine in the treatment of pervasive developmental disorders
    Adam H Corson
    Department of Psychiatry, Indiana University School of Medicine and Christian Sarkine Autism Treatment Center, James Whitcomb Riley Hospital for Children, Indianapolis, Ind 46202 4800, USA
    J Clin Psychiatry 65:1531-6. 2004
    ..The purpose of this study was to examine the effectiveness and tolerability of quetiapine for aggression, hyperactivity, and self-injury in pervasive developmental disorders (PDDs)...
  11. ncbi request reprint Treatment of aggression in children and adolescents with autism and conduct disorder
    Christopher J McDougle
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Clin Psychiatry 64:16-25. 2003
    ....
  12. ncbi request reprint A naturalistic open-label study of mirtazapine in autistic and other pervasive developmental disorders
    D J Posey
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, USA
    J Child Adolesc Psychopharmacol 11:267-77. 2001
    ..CONCLUSIONS: Mirtazapine was well tolerated but showed only modest effectiveness for treating the associated symptoms of autistic disorder and other PDDs...
  13. ncbi request reprint Case series: use of ziprasidone for maladaptive symptoms in youths with autism
    Christopher J McDougle
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis 46202 4800, USA
    J Am Acad Child Adolesc Psychiatry 41:921-7. 2002
    ..To conduct a preliminary evaluation of the safety and effectiveness of ziprasidone in children, adolescents, and young adults with autism...
  14. ncbi request reprint Repetitive thoughts and behavior in pervasive developmental disorders: treatment with serotonin reuptake inhibitors
    C J McDougle
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, USA
    J Autism Dev Disord 30:427-35. 2000
    ..One controlled study of the selective SRI fluvoxamine found it to be significantly better than placebo for reducing repetitive phenomena and aggression in adults with autistic disorder. Additional research is needed...
  15. ncbi request reprint Neurochemistry in the pathophysiology of autism
    Christopher J McDougle
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202 4800, USA
    J Clin Psychiatry 66:9-18. 2005
    ..As these efforts move forward, it will be important to begin to integrate genetic studies with those involving neuroimaging and postmortem research in each of these 3 areas, as well as with pharmacologic treatment approaches...
  16. ncbi request reprint Risperidone in pervasive developmental disorders
    Craig A Erickson
    Riley Hospital, Child and Adolescent Psychiatry Clinic, 702 Barnhill Drive, ROC 4300, Indianapolis, IN 46202, USA
    Expert Rev Neurother 5:713-9. 2005
    ..Finally, a discussion of the future direction of risperidone use in this population and key issues will be presented...
  17. pmc Aripiprazole in autism spectrum disorders and fragile X syndrome
    Craig A Erickson
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Neurotherapeutics 7:258-63. 2010
    ..However, research to date in this disorder has not focused on this target symptom cluster. An initial pilot study has begun to assess the impact of aripiprazole on irritability in youth with fragile X syndrome...
  18. ncbi request reprint A retrospective study of memantine in children and adolescents with pervasive developmental disorders
    Craig A Erickson
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA
    Psychopharmacology (Berl) 191:141-7. 2007
    ..There are no drugs that have been shown to effectively treat the core social impairment of autism...
  19. ncbi request reprint Atypical antipsychotics in children and adolescents with autistic and other pervasive developmental disorders
    Christopher J McDougle
    Department of Psychiatry, Indiana University School of Medicine, Christian Sarkine Autism Treatment Center, James Whitcomb Riley Hospital for Children, Indianapolis, IN 46202 4800, USA
    J Clin Psychiatry 69:15-20. 2008
    ..Additional placebo-controlled trials and studies of longer-term safety and tolerability are needed...
  20. pmc Aripiprazole in pervasive developmental disorder not otherwise specified and Asperger's disorder: a 14-week, prospective, open-label study
    Kimberly A Stigler
    Department of Psychiatry, Section of Child and Adolescent Psychiatry, Indiana University School of Medicine and Christian Sarkine Autism Treatment Center, James Whitcomb Riley Hospital for Children, Indianapolis, Indiana 46202 5200, USA
    J Child Adolesc Psychopharmacol 19:265-74. 2009
    ..The aim of this study was to determine the effectiveness and tolerability of aripiprazole for irritability in pervasive developmental disorder not otherwise specified (PDD-NOS) and Asperger's disorder...
  21. ncbi request reprint Ramelteon for insomnia in two youths with autistic disorder
    Kimberly A Stigler
    Department of Psychiatry, Indiana University School of Medicine and the Christian Sarkine Autism Treatment Center at the James Whitcomb Riley Hospital for Children, Indianapolis, Indiana 46202 5200, USA
    J Child Adolesc Psychopharmacol 16:631-6. 2006
    ..The aim of this study was to report preliminary data on the effectiveness and tolerability of ramelteon for the treatment of insomnia in youth with autistic disorder (autism)...
  22. ncbi request reprint Risperidone for the core symptom domains of autism: results from the study by the autism network of the research units on pediatric psychopharmacology
    Christopher J McDougle
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202 4800, USA
    Am J Psychiatry 162:1142-8. 2005
    ..The authors report on whether risperidone improves the core symptoms of autism, social and communication impairment and repetitive and stereotyped behavior...
  23. ncbi request reprint Research Units on Pediatric Psychopharmacology (RUPP) Autism Network. Background and rationale for an initial controlled study of risperidone
    C J McDougle
    University School of Medicine, Indianapolis, Indiana, USA
    Child Adolesc Psychiatr Clin N Am 9:201-24. 2000
    ..The design of this study and the assessments used are described separately...
  24. ncbi request reprint Aripiprazole for maladaptive behavior in pervasive developmental disorders
    Kimberly A Stigler
    Department of Psychiatry, Indiana University School of Medicine and the James Whitcomb Riley Hospital for Children, Indianapolis, IN 46202, USA
    J Child Adolesc Psychopharmacol 14:455-63. 2004
    ..The aim of this study was to obtain preliminary data regarding the effectiveness and tolerability of aripiprazole in the treatment of children and adolescents with a pervasive developmental disorder (PDD)...
  25. ncbi request reprint A pilot study of D-cycloserine in subjects with autistic disorder
    David J Posey
    Riley Hospital for Children, Room 4300, 702 Barnhill Drive, Indianapolis, IN 46220, USA
    Am J Psychiatry 161:2115-7. 2004
    ..The authors assessed the effects of D-cycloserine on the core symptom of social impairment in subjects with autism...
  26. ncbi request reprint The pathophysiology and treatment of autism
    D J Posey
    Department of Psychiatry, Indiana University School of Medicine, 541 Clinical Drive, Indianapolis, IN 46202, USA
    Curr Psychiatry Rep 3:101-8. 2001
    ..Significant gains have been made in determining which pharmacologic treatments are efficacious in autism. Additional research is needed on agents that might ameliorate the core and associated symptoms of autism...
  27. pmc Moderators, mediators, and other predictors of risperidone response in children with autistic disorder and irritability
    L Eugene Arnold
    Department of Psychiatry, Ohio State University, Columbus, Ohio, USA
    J Child Adolesc Psychopharmacol 20:83-93. 2010
    ..2 in favor of risperidone on the main outcome measure in an 8-week double-blind, placebo-controlled trial for irritability in autistic disorder. This paper explores moderators and mediators of this effect...
  28. ncbi request reprint Intramuscular ziprasidone for acute agitation in adolescents
    Emmeline Hazaray
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Child Adolesc Psychopharmacol 14:464-70. 2004
    ..In our study, we report the cases of 3 youngsters whose escalating aggression responded to intramuscular ziprasidone with an immediate calming effect and good clinical outcome...
  29. ncbi request reprint A naturalistic retrospective analysis of psychostimulants in pervasive developmental disorders
    Kimberly A Stigler
    Department of Psychiatry, Indiana University School of Medicine, James Whitcomb Riley Hospital for Children, Indianapolis, Indiana, USA
    J Child Adolesc Psychopharmacol 14:49-56. 2004
    ..We set out to examine the effectiveness and tolerability of psychostimulants in children and adolescents with pervasive developmental disorders (PDDs)...
  30. ncbi request reprint Increased prevalence of familial autoimmunity in probands with pervasive developmental disorders
    Thayne L Sweeten
    Department of Psychiatry, Indiana University School of Medicine, and James Whitcomb Riley Hospital for Children Indianapolis 46202 4800, USA
    Pediatrics 112:e420. 2003
    ..We further investigated this association by determining the frequency of autoimmune disorders in families that have probands with pervasive developmental disorders (PDDs), including autism, compared with 2 control groups...
  31. ncbi request reprint Pharmacologic treatment of autism and related disorders
    Craig A Erickson
    Department of Psychiatry, Indiana University School of Medicine, and the Christian Sarkine Autism Treatment Center, James Whitcomb Riley Hospital for Children, Indianapolis 46202 4800, USA
    Pediatr Ann 36:575-85. 2007
  32. ncbi request reprint Weight gain associated with atypical antipsychotic use in children and adolescents: prevalence, clinical relevance, and management
    Kimberly A Stigler
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46202 4800, USA
    Paediatr Drugs 6:33-44. 2004
    ....
  33. ncbi request reprint High blood monocyte counts and neopterin levels in children with autistic disorder
    Thayne L Sweeten
    Department of Psychiatry, Indiana University School of Medicine, 1111 West 10th Street, Indianapolis, IN 46202 4800, USA
    Am J Psychiatry 160:1691-3. 2003
    ..Leukocyte counts and plasma neopterin levels were determined in autistic children and matched healthy comparison subjects...
  34. ncbi request reprint The amygdala and related structures in the pathophysiology of autism
    Thayne L Sweeten
    Department of Psychiatry, Indiana University School of Medicine, 541 Clinical Drive, Room 298, Indianapolis, IN 46202 5111, USA
    Pharmacol Biochem Behav 71:449-55. 2002
    ..Although supportive evidence exists for amygdala dysfunction in autism, the currently available data are inconsistent and additional research is needed...
  35. ncbi request reprint High nitric oxide production in autistic disorder: a possible role for interferon-gamma
    Thayne L Sweeten
    Department of Psychiatry, Indiana University School of Medicine, 1111 W 10th Street, Indianapolis, IN 46202 4800, USA
    Biol Psychiatry 55:434-7. 2004
    ..The purpose of this study was to verify that plasma NO is high in children with autism and determine whether this elevation is related to plasma levels of cytokines involved in NO production...
  36. ncbi request reprint Brief report: autistic disorder in three children with cytomegalovirus infection
    Thayne L Sweeten
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202 4800, USA
    J Autism Dev Disord 34:583-6. 2004
    ..A better understanding of the immunologic response to certain congenital infections may provide important information pertaining to the pathophysiology and etiology of autism in vulnerable individuals...
  37. ncbi request reprint Gastrointestinal factors in autistic disorder: a critical review
    Craig A Erickson
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis 46202 4800, USA
    J Autism Dev Disord 35:713-27. 2005
    ..While much literature is available on this topic, a dearth of rigorous study was found to validate GI factors specific to children with autism...
  38. ncbi request reprint Dietary status and impact of risperidone on nutritional balance in children with autism: a pilot study
    Ronald L Lindsay
    Children s Health Center of St Joseph s Hospital and Medical Center, Arizona 85013, USA
    J Intellect Dev Disabil 31:204-9. 2006
    ..Risperidone may be effective in improving tantrums, aggression, or self-injurious behaviour in children with autism, but often leads to weight gain...
  39. ncbi request reprint Assessment of the integrity of study blindness in a pediatric clinical trial of risperidone
    Benedetto Vitiello
    Division of Services and Intervention Research, National Institute of Mental Health, Bethesda, MD 20892 9633, USA
    J Clin Psychopharmacol 25:565-9. 2005
    ..The blindness of clinical evaluators and parents was examined in a clinical trial of risperidone in autism...
  40. ncbi request reprint Acute and long-term safety and tolerability of risperidone in children with autism
    Michael G Aman
    The Nisonger Center, Ohio State University, Columbus, Ohio 43210 1296, USA
    J Child Adolesc Psychopharmacol 15:869-84. 2005
    ..Most AEs were mild to moderate and failed to interfere with therapeutic changes; there were no unanticipated AEs. The side effects of most concern were somnolence and weight gain...
  41. ncbi request reprint Risperidone and adaptive behavior in children with autism
    Susan K Williams
    Yale University, New Haven, CT 06520 7900, USA
    J Am Acad Child Adolesc Psychiatry 45:431-9. 2006
    ..To evaluate the impact of risperidone on adaptive behavior in children with autistic disorder who have serious behavior problems and to examine different methods of scoring the Vineland Adaptive Behavior Scales to measure change...
  42. ncbi request reprint Effects of short- and long-term risperidone treatment on prolactin levels in children with autism
    George M Anderson
    Child Study Center, Yale University School of Medicine, New Haven, Connecticut, USA
    Biol Psychiatry 61:545-50. 2007
    ..The effects of short- and long-term risperidone treatment on serum prolactin were assessed in children and adolescents with autism...
  43. ncbi request reprint Children's Yale-Brown Obsessive Compulsive Scale modified for pervasive developmental disorders
    Lawrence Scahill
    Yale Child Study Center, Yale University, New Haven, CT 06520, USA
    J Am Acad Child Adolesc Psychiatry 45:1114-23. 2006
    ..To examine the psychometric properties of the Children's Yale-Brown Obsessive Compulsive Scales (CYBOCS) modified for pervasive developmental disorders (PDDs)...
  44. ncbi request reprint Priapism associated with trazodone in an adolescent with autism
    Deborah L Kem
    J Am Acad Child Adolesc Psychiatry 41:758. 2002
  45. ncbi request reprint Validity of the autism diagnostic interview-revised
    Luc Lecavalier
    Nisonger Center, The Ohio State University, Columbus, USA
    Am J Ment Retard 111:199-215. 2006
    ..They indicated some similarities between constructs, but also that the ADI-R measures autism in a unique fashion...

Research Grants4

  1. Psychopharmacology of Autism and related Disorders
    David Posey; Fiscal Year: 2007
    ..Towards the later years of the award, the candidate will have performed additional studies and applied for independent research funding. ..
  2. Targeted Pharmacologic Interventions for Autism
    David Posey; Fiscal Year: 2007
    ..This research is also unique in its plan to identify genetic predictors of response to drug treatment in autism. ..
  3. Targeted Pharmacologic Interventions for Autism
    David Posey; Fiscal Year: 2009
    ..This research is also unique in its plan to identify genetic predictors of response to drug treatment in autism. ..