Research Topics
| D J PoseySummaryAffiliation: Indiana University Country: USA Publications
Research Grants
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Detail Information
Publications
The use of selective serotonin reuptake inhibitors in autism and related disordersDavid J Posey
Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
J Child Adolesc Psychopharmacol 16:181-6. 2006..Larger, placebo-controlled studies of SSRIs are needed to guide clinical treatment...- Guanfacine treatment of hyperactivity and inattention in pervasive developmental disorders: a retrospective analysis of 80 casesDavid J Posey
Department of Psychiatry, Indiana University School of Medicine, Riley Hospital for Children, 702 Barnhill Drive, Indianapolis, IN 46202 5200, USA
J Child Adolesc Psychopharmacol 14:233-41. 2004.... - Open-label atomoxetine for attention-deficit/ hyperactivity disorder symptoms associated with high-functioning pervasive developmental disordersDavid J Posey
Department of Psychiatry and Christian Sarkine Autism Treatment Center at the Indiana University School of Medicine, Indianapolis, Indiana, USA
J Child Adolesc Psychopharmacol 16:599-610. 2006..The aim of this study was to conduct an initial evaluation of the efficacy of atomoxetine for attention-deficit/hyperactivity disorder (ADHD) symptoms in children with pervasive developmental disorders (PDDs)... 
Antipsychotics in the treatment of autismDavid J Posey
Christian Sarkine Autism Treatment Center, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
J Clin Invest 118:6-14. 2008..Significant adverse effects, including weight gain and the possibility of tardive dyskinesia, are reviewed. Future research directions are discussed...- Positive effects of methylphenidate on inattention and hyperactivity in pervasive developmental disorders: an analysis of secondary measuresDavid J Posey
Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana, USA
Biol Psychiatry 61:538-44. 2007.... - Guanfacine and guanfacine extended release: treatment for ADHD and related disordersDavid J Posey
Christian Sarkine Autism Treatment Center, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA
CNS Drug Rev 13:465-74. 2007..Adverse cardiovascular effects are uncommon, although modest reductions in blood pressure and heart rate are common. If GXR is FDA-approved, it would be the first alpha(2A) adrenoceptor agonist marketed for ADHD... - Risperidone: a potential treatment for autismDavid J Posey
Riley Hospital for Children, Indianapolis, IN 46202, USA
Curr Opin Investig Drugs 3:1212-6. 2002..Individuals with autism may also have other symptoms that become the primary focus of psychiatric treatment. These associated symptoms include aggression, self-injury, irritability and anxiety... - Developing drugs for core social and communication impairment in autismDavid J Posey
Department of Psychiatry, Indiana University School of Medicine, 1111 West 10th Street, Indianapolis, IN 46202 4800, USA
Child Adolesc Psychiatr Clin N Am 17:787-801, viii-ix. 2008..More research is needed on the utility of selective serotonin reuptake inhibitors, cholinergic drugs, glutamatergic drugs, and oxytocin for core autistic symptoms... - Pharmacotherapeutic management of autismD J Posey
Department of Psychiatry, Indaiana University School of Medicine, USA
Expert Opin Pharmacother 2:587-600. 2001..Current pharmacological management is best aimed at target symptoms that have been demonstrated to respond to medication in treatment studies... - A retrospective analysis of quetiapine in the treatment of pervasive developmental disordersAdam H Corson
Department of Psychiatry, Indiana University School of Medicine and Christian Sarkine Autism Treatment Center, James Whitcomb Riley Hospital for Children, Indianapolis, Ind. 46202-4800, USA
J Clin Psychiatry 65:1531-6. 2004..CONCLUSION: Quetiapine was modestly effective for maladaptive behavior in patients with a PDD. Controlled studies are needed to further assess these preliminary findings... - Treatment of aggression in children and adolescents with autism and conduct disorderChristopher J McDougle
Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202, USA
J Clin Psychiatry 64:16-25. 2003.... - A naturalistic open-label study of mirtazapine in autistic and other pervasive developmental disordersD J Posey
Department of Psychiatry, Indiana University School of Medicine, Indianapolis, USA
J Child Adolesc Psychopharmacol 11:267-77. 2001..CONCLUSIONS: Mirtazapine was well tolerated but showed only modest effectiveness for treating the associated symptoms of autistic disorder and other PDDs... - Case series: use of ziprasidone for maladaptive symptoms in youths with autismChristopher J McDougle
Department of Psychiatry, Indiana University School of Medicine, Indianapolis 46202-4800, USA
J Am Acad Child Adolesc Psychiatry 41:921-7. 2002..Significant weight gain was not observed in this short-term trial. Double-blind, placebo-controlled studies are needed to substantiate these preliminary findings... - Repetitive thoughts and behavior in pervasive developmental disorders: treatment with serotonin reuptake inhibitorsC J McDougle
Department of Psychiatry, Indiana University School of Medicine, Indianapolis, USA
J Autism Dev Disord 30:427-35. 2000..One controlled study of the selective SRI fluvoxamine found it to be significantly better than placebo for reducing repetitive phenomena and aggression in adults with autistic disorder. Additional research is needed... - Neurochemistry in the pathophysiology of autismChristopher J McDougle
Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202 4800, USA
J Clin Psychiatry 66:9-18. 2005..As these efforts move forward, it will be important to begin to integrate genetic studies with those involving neuroimaging and postmortem research in each of these 3 areas, as well as with pharmacologic treatment approaches... - Risperidone in pervasive developmental disordersCraig A Erickson
Riley Hospital, Child and Adolescent Psychiatry Clinic, 702 Barnhill Drive, ROC 4300, Indianapolis, IN 46202, USA
Expert Rev Neurother 5:713-9. 2005..Finally, a discussion of the future direction of risperidone use in this population and key issues will be presented... - Aripiprazole in autism spectrum disorders and fragile X syndromeCraig A Erickson
Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Neurotherapeutics 7:258-63. 2010..However, research to date in this disorder has not focused on this target symptom cluster. An initial pilot study has begun to assess the impact of aripiprazole on irritability in youth with fragile X syndrome... - A retrospective study of memantine in children and adolescents with pervasive developmental disordersCraig A Erickson
Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA
Psychopharmacology (Berl) 191:141-7. 2007..There are no drugs that have been shown to effectively treat the core social impairment of autism... - Atypical antipsychotics in children and adolescents with autistic and other pervasive developmental disordersChristopher J McDougle
Department of Psychiatry, Indiana University School of Medicine, Christian Sarkine Autism Treatment Center, James Whitcomb Riley Hospital for Children, Indianapolis, IN 46202 4800, USA
J Clin Psychiatry 69:15-20. 2008..Additional placebo-controlled trials and studies of longer-term safety and tolerability are needed... - Aripiprazole in pervasive developmental disorder not otherwise specified and Asperger's disorder: a 14-week, prospective, open-label studyKimberly A Stigler
Department of Psychiatry, Section of Child and Adolescent Psychiatry, Indiana University School of Medicine and Christian Sarkine Autism Treatment Center, James Whitcomb Riley Hospital for Children, Indianapolis, Indiana 46202 5200, USA
J Child Adolesc Psychopharmacol 19:265-74. 2009..The aim of this study was to determine the effectiveness and tolerability of aripiprazole for irritability in pervasive developmental disorder not otherwise specified (PDD-NOS) and Asperger's disorder... - Ramelteon for insomnia in two youths with autistic disorderKimberly A Stigler
Department of Psychiatry, Indiana University School of Medicine and the Christian Sarkine Autism Treatment Center at the James Whitcomb Riley Hospital for Children, Indianapolis, Indiana 46202 5200, USA
J Child Adolesc Psychopharmacol 16:631-6. 2006..The aim of this study was to report preliminary data on the effectiveness and tolerability of ramelteon for the treatment of insomnia in youth with autistic disorder (autism)... - Risperidone for the core symptom domains of autism: results from the study by the autism network of the research units on pediatric psychopharmacologyChristopher J McDougle
Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202 4800, USA
Am J Psychiatry 162:1142-8. 2005..The authors report on whether risperidone improves the core symptoms of autism, social and communication impairment and repetitive and stereotyped behavior... - Research Units on Pediatric Psychopharmacology (RUPP) Autism Network. Background and rationale for an initial controlled study of risperidoneC J McDougle
University School of Medicine, Indianapolis, Indiana, USA
Child Adolesc Psychiatr Clin N Am 9:201-24. 2000..The design of this study and the assessments used are described separately... - Aripiprazole for maladaptive behavior in pervasive developmental disordersKimberly A Stigler
Department of Psychiatry, Indiana University School of Medicine and the James Whitcomb Riley Hospital for Children, Indianapolis, IN 46202, USA
J Child Adolesc Psychopharmacol 14:455-63. 2004..No significant adverse effects emerged during these short-term trials. Additional research is needed to support these preliminary findings... - A pilot study of D-cycloserine in subjects with autistic disorderDavid J Posey
Riley Hospital for Children, Room 4300, 702 Barnhill Drive, Indianapolis, IN 46220, USA
Am J Psychiatry 161:2115-7. 2004..CONCLUSIONS: In this pilot study, D-cycloserine treatment resulted in significant improvement in social withdrawal. Further controlled studies of D-cycloserine in autism appear warranted... - The pathophysiology and treatment of autismD J Posey
Department of Psychiatry, Indiana University School of Medicine, 541 Clinical Drive, Indianapolis, IN 46202, USA
Curr Psychiatry Rep 3:101-8. 2001..Significant gains have been made in determining which pharmacologic treatments are efficacious in autism. Additional research is needed on agents that might ameliorate the core and associated symptoms of autism... - Moderators, mediators, and other predictors of risperidone response in children with autistic disorder and irritabilityL Eugene Arnold
Department of Psychiatry, Ohio State University, Columbus, Ohio, USA
J Child Adolesc Psychopharmacol 20:83-93. 2010..2 in favor of risperidone on the main outcome measure in an 8-week double-blind, placebo-controlled trial for irritability in autistic disorder. This paper explores moderators and mediators of this effect... - Intramuscular ziprasidone for acute agitation in adolescentsEmmeline Hazaray
Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202, USA
J Child Adolesc Psychopharmacol 14:464-70. 2004..In our study, we report the cases of 3 youngsters whose escalating aggression responded to intramuscular ziprasidone with an immediate calming effect and good clinical outcome... - A naturalistic retrospective analysis of psychostimulants in pervasive developmental disordersKimberly A Stigler
Department of Psychiatry, Indiana University School of Medicine, James Whitcomb Riley Hospital for Children, Indianapolis, Indiana, USA
J Child Adolesc Psychopharmacol 14:49-56. 2004..Response may differ with PDD subtype. Controlled studies are needed to further evaluate these preliminary findings in a systematic manner... - Increased prevalence of familial autoimmunity in probands with pervasive developmental disordersThayne L Sweeten
Department of Psychiatry, Indiana University School of Medicine, and James Whitcomb Riley Hospital for Children Indianapolis 46202-4800, USA
Pediatrics 112:e420. 2003..These preliminary findings warrant additional investigation into immune and autoimmune mechanisms in autism... - Pharmacologic treatment of autism and related disordersCraig A Erickson
Department of Psychiatry, Indiana University School of Medicine, and the Christian Sarkine Autism Treatment Center, James Whitcomb Riley Hospital for Children, Indianapolis 46202-4800, USA
Pediatr Ann 36:575-85. 2007 - Weight gain associated with atypical antipsychotic use in children and adolescents: prevalence, clinical relevance, and managementKimberly A Stigler
Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46202-4800, USA
Paediatr Drugs 6:33-44. 2004.... - High blood monocyte counts and neopterin levels in children with autistic disorderThayne L Sweeten
Department of Psychiatry, Indiana University School of Medicine, 1111 West 10th Street, Indianapolis, IN 46202-4800, USA
Am J Psychiatry 160:1691-3. 2003..RESULTS: The monocyte count and neopterin level were significantly higher in the autistic children than in the comparison subjects. CONCLUSIONS: These results suggest that the immune system may be activated in some children with autism... - The amygdala and related structures in the pathophysiology of autismThayne L Sweeten
Department of Psychiatry, Indiana University School of Medicine, 541 Clinical Drive, Room 298, Indianapolis, IN 46202-5111, USA
Pharmacol Biochem Behav 71:449-55. 2002..Although supportive evidence exists for amygdala dysfunction in autism, the currently available data are inconsistent and additional research is needed... - High nitric oxide production in autistic disorder: a possible role for interferon-gammaThayne L Sweeten
Department of Psychiatry, Indiana University School of Medicine, 1111 W. 10th Street, Indianapolis, IN 46202-4800, USA
Biol Psychiatry 55:434-7. 2004..51; p =.005). CONCLUSIONS: These results confirm that plasma NO is high in some children with autism and suggest that this elevation may be related to IFN-gamma activity... - Brief report: autistic disorder in three children with cytomegalovirus infectionThayne L Sweeten
Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202-4800, USA
J Autism Dev Disord 34:583-6. 2004..A better understanding of the immunologic response to certain congenital infections may provide important information pertaining to the pathophysiology and etiology of autism in vulnerable individuals... - Gastrointestinal factors in autistic disorder: a critical reviewCraig A Erickson
Department of Psychiatry, Indiana University School of Medicine, Indianapolis 46202-4800, USA
J Autism Dev Disord 35:713-27. 2005..While much literature is available on this topic, a dearth of rigorous study was found to validate GI factors specific to children with autism... - Dietary status and impact of risperidone on nutritional balance in children with autism: a pilot studyRonald L Lindsay
Children s Health Center of St Joseph s Hospital and Medical Center, Arizona 85013, USA
J Intellect Dev Disabil 31:204-9. 2006..Risperidone may be effective in improving tantrums, aggression, or self-injurious behaviour in children with autism, but often leads to weight gain... - Assessment of the integrity of study blindness in a pediatric clinical trial of risperidoneBenedetto Vitiello
Division of Services and Intervention Research, National Institute of Mental Health, Bethesda, MD 20892 9633, USA
J Clin Psychopharmacol 25:565-9. 2005..The blindness of clinical evaluators and parents was examined in a clinical trial of risperidone in autism... - Acute and long-term safety and tolerability of risperidone in children with autismMichael G Aman
The Nisonger Center, Ohio State University, Columbus, Ohio 43210 1296, USA
J Child Adolesc Psychopharmacol 15:869-84. 2005..Most AEs were mild to moderate and failed to interfere with therapeutic changes; there were no unanticipated AEs. The side effects of most concern were somnolence and weight gain... - Risperidone and adaptive behavior in children with autismSusan K Williams
Yale University, New Haven, CT 06520-7900, USA
J Am Acad Child Adolesc Psychiatry 45:431-9. 2006..Vineland age-equivalent scores appear to be most useful in assessing change with treatment over time... - Effects of short- and long-term risperidone treatment on prolactin levels in children with autismGeorge M Anderson
Child Study Center, Yale University School of Medicine, New Haven, Connecticut, USA
Biol Psychiatry 61:545-50. 2007..The effects of short- and long-term risperidone treatment on serum prolactin were assessed in children and adolescents with autism... - Children's Yale-Brown Obsessive Compulsive Scale modified for pervasive developmental disordersLawrence Scahill
Yale Child Study Center, Yale University, New Haven, CT 06520, USA
J Am Acad Child Adolesc Psychiatry 45:1114-23. 2006..To examine the psychometric properties of the Children's Yale-Brown Obsessive Compulsive Scales (CYBOCS) modified for pervasive developmental disorders (PDDs)... - Priapism associated with trazodone in an adolescent with autismDeborah L Kem
J Am Acad Child Adolesc Psychiatry 41:758. 2002 - Validity of the autism diagnostic interview-revisedLuc Lecavalier
Nisonger Center, The Ohio State University, Columbus, USA
Am J Ment Retard 111:199-215. 2006..They indicated some similarities between constructs, but also that the ADI-R measures autism in a unique fashion...
Research Grants
- Psychopharmacology of Autism and related DisordersDavid Posey; Fiscal Year: 2007..Towards the later years of the award, the candidate will have performed additional studies and applied for independent research funding. ..
- Targeted Pharmacologic Interventions for AutismDavid Posey; Fiscal Year: 2007..This research is also unique in its plan to identify genetic predictors of response to drug treatment in autism. ..
- Targeted Pharmacologic Interventions for AutismDavid Posey; Fiscal Year: 2009..This research is also unique in its plan to identify genetic predictors of response to drug treatment in autism. ..