I Petrache

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. pmc Safety and efficacy of alpha-1-antitrypsin augmentation therapy in the treatment of patients with alpha-1-antitrypsin deficiency
    Irina Petrache
    Department of Medicine, Indiana, University School of Medicine, Indianapolis, Indiana, USA
    Biologics 3:193-204. 2009
  2. doi request reprint The involvement of sphingolipids in chronic obstructive pulmonary diseases
    Irina Petrache
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Handb Exp Pharmacol 216:247-64. 2013
  3. pmc RTP801 is required for ceramide-induced cell-specific death in the murine lung
    Krzysztof Kamocki
    Department of Biochemistry and Molecular Biology, Indianapolis, IN 46202, USA
    Am J Respir Cell Mol Biol 48:87-93. 2013
  4. pmc Involvement of ceramide in cell death responses in the pulmonary circulation
    Irina Petrache
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Indiana University, Indianapolis, Indiana, USA
    Proc Am Thorac Soc 8:492-6. 2011
  5. pmc Mechanisms of lung endothelial barrier disruption induced by cigarette smoke: role of oxidative stress and ceramides
    Kelly S Schweitzer
    Department of Medicine, Indiana University School of Medicine, Indianapolis, 46202 5120, USA
    Am J Physiol Lung Cell Mol Physiol 301:L836-46. 2011
  6. doi request reprint HIV associated pulmonary emphysema: a review of the literature and inquiry into its mechanism
    I Petrache
    Division of Pulmonary, Allergy, Critical Care and Occupational Medicine, Indiana University, Van Nuys Medical Science Building, 635 Barnhill Drive, MS224, Indianapolis, IN 46202 5120, USA
    Thorax 63:463-9. 2008
  7. pmc Superoxide dismutase protects against apoptosis and alveolar enlargement induced by ceramide
    Irina Petrache
    Division of Pulmonary, Allergy, Critical Care, and Occupational Medicine, Indiana University, Indianapolis, Indiana 46202 5120, USA
    Am J Physiol Lung Cell Mol Physiol 295:L44-53. 2008
  8. pmc alpha-1 antitrypsin inhibits caspase-3 activity, preventing lung endothelial cell apoptosis
    Irina Petrache
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Pathol 169:1155-66. 2006
  9. ncbi request reprint Ceramide causes pulmonary cell apoptosis and emphysema: a role for sphingolipid homeostasis in the maintenance of alveolar cells
    Irina Petrache
    Division of Pulmonary, Allergy, Critical Care and Occupational Medicine, Indiana University School of Medicine, Indianapolis, 46202, USA
    Proc Am Thorac Soc 3:510. 2006
  10. pmc A novel antiapoptotic role for alpha1-antitrypsin in the prevention of pulmonary emphysema
    Irina Petrache
    Division of Pulmonary and Critical Care, Department of Medicine, John Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Respir Crit Care Med 173:1222-8. 2006

Research Grants

  1. CYTOSKELETAL REGULATION OF ENDOTHELIAL CELL APOPTOSIS
    Irina Petrache; Fiscal Year: 2004
  2. Ceramide-induced lung destruction in emphysema
    Irina Petrache; Fiscal Year: 2006
  3. Ceramide-induced lung destruction in emphysema
    Irina Petrache; Fiscal Year: 2007
  4. Ceramide-induced lung destruction in emphysema
    Irina Petrache; Fiscal Year: 2009
  5. Ceramide-induced lung destruction in emphysema
    Irina Petrache; Fiscal Year: 2009
  6. Ceramide-induced lung destruction in emphysema
    Irina Petrache; Fiscal Year: 2010

Collaborators

Detail Information

Publications27

  1. pmc Safety and efficacy of alpha-1-antitrypsin augmentation therapy in the treatment of patients with alpha-1-antitrypsin deficiency
    Irina Petrache
    Department of Medicine, Indiana, University School of Medicine, Indianapolis, Indiana, USA
    Biologics 3:193-204. 2009
    ..In this article, we review the published evidence of A1AT augmentation therapy efficacy, side effects, and safety profile...
  2. doi request reprint The involvement of sphingolipids in chronic obstructive pulmonary diseases
    Irina Petrache
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Handb Exp Pharmacol 216:247-64. 2013
    ..This chapter discusses current evidence of sphingolipid perturbations in experimental models of COPD and relevant links to human disease based on translational and epidemiological data...
  3. pmc RTP801 is required for ceramide-induced cell-specific death in the murine lung
    Krzysztof Kamocki
    Department of Biochemistry and Molecular Biology, Indianapolis, IN 46202, USA
    Am J Respir Cell Mol Biol 48:87-93. 2013
    ..In conclusion, ceramide and RTP801 participate in alveolar cell apoptosis through a process of mutual up-regulation, which may result in self-amplification loops, leading to alveolar damage...
  4. pmc Involvement of ceramide in cell death responses in the pulmonary circulation
    Irina Petrache
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Indiana University, Indianapolis, Indiana, USA
    Proc Am Thorac Soc 8:492-6. 2011
    ....
  5. pmc Mechanisms of lung endothelial barrier disruption induced by cigarette smoke: role of oxidative stress and ceramides
    Kelly S Schweitzer
    Department of Medicine, Indiana University School of Medicine, Indianapolis, 46202 5120, USA
    Am J Physiol Lung Cell Mol Physiol 301:L836-46. 2011
    ..Amelioration of endothelial permeability may alleviate lung and systemic vascular dysfunction associated with smoking-related chronic obstructive lung diseases...
  6. doi request reprint HIV associated pulmonary emphysema: a review of the literature and inquiry into its mechanism
    I Petrache
    Division of Pulmonary, Allergy, Critical Care and Occupational Medicine, Indiana University, Van Nuys Medical Science Building, 635 Barnhill Drive, MS224, Indianapolis, IN 46202 5120, USA
    Thorax 63:463-9. 2008
    ..A better understanding of the pathogenesis of HIV associated pulmonary emphysema may provide clues and therapeutic targets that have broader application in this disease, including cigarette smoke induced emphysema...
  7. pmc Superoxide dismutase protects against apoptosis and alveolar enlargement induced by ceramide
    Irina Petrache
    Division of Pulmonary, Allergy, Critical Care, and Occupational Medicine, Indiana University, Indianapolis, Indiana 46202 5120, USA
    Am J Physiol Lung Cell Mol Physiol 295:L44-53. 2008
    ..This work implicates excessive lung ceramides as amplifiers of lung injury through redox-dependent mechanisms...
  8. pmc alpha-1 antitrypsin inhibits caspase-3 activity, preventing lung endothelial cell apoptosis
    Irina Petrache
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Pathol 169:1155-66. 2006
    ....
  9. ncbi request reprint Ceramide causes pulmonary cell apoptosis and emphysema: a role for sphingolipid homeostasis in the maintenance of alveolar cells
    Irina Petrache
    Division of Pulmonary, Allergy, Critical Care and Occupational Medicine, Indiana University School of Medicine, Indianapolis, 46202, USA
    Proc Am Thorac Soc 3:510. 2006
  10. pmc A novel antiapoptotic role for alpha1-antitrypsin in the prevention of pulmonary emphysema
    Irina Petrache
    Division of Pulmonary and Critical Care, Department of Medicine, John Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Respir Crit Care Med 173:1222-8. 2006
    ..The association of alpha1-antitrypsin deficiency with the development of emphysema has supported the concept that protease/antiprotease imbalance mediates cigarette smoke-induced emphysema...
  11. doi request reprint Stimulation of sphingosine 1-phosphate signaling as an alveolar cell survival strategy in emphysema
    Khalil J Diab
    Division of Pulmonary, Allergy, Critical Care, and Occupational Medicine, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202 5120, USA
    Am J Respir Crit Care Med 181:344-52. 2010
    ..The effects of increased endogenous ceramides could be offset by sphingosine 1-phosphate (S1P), a prosurvival by-product of ceramide metabolism...
  12. pmc Apoptotic sphingolipid signaling by ceramides in lung endothelial cells
    Terry R Medler
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Respir Cell Mol Biol 38:639-46. 2008
    ..The serine palmitoyl synthase-regulated ceramides synthesis may contribute to the amplification of pulmonary vascular injury induced by excessive ceramides...
  13. pmc Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice
    Irina Petrache
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, 5501 Hopkins Bayview Circle, JHAAC, 4B 65, Baltimore, Maryland 21224, USA
    Nat Med 11:491-8. 2005
    ..Finally, increased lung ceramides in individuals with smoking-induced emphysema suggests that ceramide upregulation may be a crucial pathogenic element and a promising target in this disease that currently lacks effective therapies...
  14. pmc Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke-induced pulmonary injury and emphysema
    Toshinori Yoshida
    Division of Cardiopulmonary Pathology, Department of Pathology, Johns Hopkins University, Baltimore, Maryland, USA
    Nat Med 16:767-73. 2010
    ..Our data support the notion that Rtp801 may represent a major molecular sensor and mediator of cigarette smoke-induced lung injury...
  15. pmc Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice
    Tirumalai Rangasamy
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Clin Invest 114:1248-59. 2004
    ..The responsiveness of the Nrf2 pathway may act as a major determinant of susceptibility to tobacco smoke-induced emphysema by upregulating antioxidant defenses and decreasing lung inflammation and alveolar cell apoptosis...
  16. pmc Role of lung maintenance program in the heterogeneity of lung destruction in emphysema
    Rubin M Tuder
    Division of Cardiopulmonary Pathology, Department of Pathology, Ross Research Building, Room 519, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Proc Am Thorac Soc 3:673-9. 2006
    ..As injury prevails during the course of this chronic disease, it leads to a more homogeneous pattern of lung disease...
  17. pmc Spinal ceramide modulates the development of morphine antinociceptive tolerance via peroxynitrite-mediated nitroxidative stress and neuroimmune activation
    Michael M Ndengele
    Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Saint Louis University School of Medicine, St Louis, MO, USA
    J Pharmacol Exp Ther 329:64-75. 2009
    ....
  18. pmc CFTR regulation of intracellular pH and ceramides is required for lung endothelial cell apoptosis
    Julie Noe
    Section of Pulmonology and Critical Care, Department of Pediatrics, Indiana University, Indianapolis, Indiana 46202 5120, USA
    Am J Respir Cell Mol Biol 41:314-23. 2009
    ..These results may have implications in the pathogenesis of cystic fibrosis, where aberrant endothelial cell death may dysregulate lung vascular homeostasis, contributing to abnormal angiogenesis and chronic inflammation...
  19. pmc State of the art. Cellular and molecular mechanisms of alveolar destruction in emphysema: an evolutionary perspective
    Rubin M Tuder
    Department of Pathology, Division of Cardiopulmonary Pathology, Ross Research Building, Ross 519, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Proc Am Thorac Soc 3:503-10. 2006
    ..An evolutionary perspective of emphysema that incorporates mechanisms related to aging may lead to important advances in the understanding and therapeutic targeting of chronic obstructive pulmonary disease...
  20. ncbi request reprint Differential effect of MLC kinase in TNF-alpha-induced endothelial cell apoptosis and barrier dysfunction
    I Petrache
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Am J Physiol Lung Cell Mol Physiol 280:L1168-78. 2001
    ..These studies indicate a central role for the endothelial cell cytoskeleton in TNF-alpha-mediated apoptosis, whereas TNF-alpha-induced vascular permeability appears to evolve independently of contractile tension generation...
  21. ncbi request reprint Pulmonary ischemia induces lung remodeling and angiogenesis
    Elizabeth M Wagner
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    J Appl Physiol (1985) 100:587-93. 2006
    ..Because sham surgeries had little effect on measured parameters, we conclude that both thoracic wound healing and pulmonary ischemia are required for systemic neovascularization...
  22. pmc Anti-type V collagen humoral immunity in lung transplant primary graft dysfunction
    Takekazu Iwata
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Immunol 181:5738-47. 2008
    ..This study demonstrates a major role for anti-col(V) humoral immunity in PGD, and identifies the airway epithelium as a target in PGD...
  23. ncbi request reprint Apoptosis and emphysema: the missing link
    Rubin M Tuder
    Division of Cardiopulmonary Pathology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Am J Respir Cell Mol Biol 28:551-4. 2003
  24. pmc Mechanism of alpha-1 antitrypsin endocytosis by lung endothelium
    Sadaf Sohrab
    Department of Medicine, Division of Pulmonary, Allergy, Critical Care and Occupational Medicine, Indiana University, Indianapolis, IN 46202, USA
    FASEB J 23:3149-58. 2009
    ..Our results suggest that clathrin-mediated endocytosis regulates A1AT intracellular function in the lung endothelium and may be an important determinant of the serpin's protection against developing cigarette smoke-induced emphysema...
  25. pmc Adipose stem cell treatment in mice attenuates lung and systemic injury induced by cigarette smoking
    Kelly S Schweitzer
    Division of Pulmonary and Critical Care Medicine, Indiana University, Indianapolis, IN 46202 5120, USA
    Am J Respir Crit Care Med 183:215-25. 2011
    ..Adipose-derived stem cells express multiple growth factors that inhibit endothelial cell apoptosis, and demonstrate substantial pulmonary trapping after intravascular delivery...
  26. ncbi request reprint The role of the microtubules in tumor necrosis factor-alpha-induced endothelial cell permeability
    Irina Petrache
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Respir Cell Mol Biol 28:574-81. 2003
    ..These results strongly suggest the involvement of microtubule rearrangement in TNF-alpha-induced endothelial cell permeability via p38 mitogen-activated protein kinase activation...
  27. pmc Molecular multitasking in the airspace: alpha1-antitrypsin takes on thrombin and plasmin
    Rubin M Tuder
    Am J Respir Cell Mol Biol 37:130-4. 2007

Research Grants7

  1. CYTOSKELETAL REGULATION OF ENDOTHELIAL CELL APOPTOSIS
    Irina Petrache; Fiscal Year: 2004
    ..abstract_text> ..
  2. Ceramide-induced lung destruction in emphysema
    Irina Petrache; Fiscal Year: 2006
    ..pro-survival sphingosine-1-P will block alveolar apoptosis and thus emphysema. Once understood, the molecular dis-regulation of ceramide could offer a target for treatments and/or prevention of emphysema. ..
  3. Ceramide-induced lung destruction in emphysema
    Irina Petrache; Fiscal Year: 2007
    ..pro-survival sphingosine-1-P will block alveolar apoptosis and thus emphysema. Once understood, the molecular dis-regulation of ceramide could offer a target for treatments and/or prevention of emphysema. ..
  4. Ceramide-induced lung destruction in emphysema
    Irina Petrache; Fiscal Year: 2009
    ..pro-survival sphingosine-1-P will block alveolar apoptosis and thus emphysema. Once understood, the molecular dis-regulation of ceramide could offer a target for treatments and/or prevention of emphysema. ..
  5. Ceramide-induced lung destruction in emphysema
    Irina Petrache; Fiscal Year: 2009
    ..pro-survival sphingosine-1-P will block alveolar apoptosis and thus emphysema. Once understood, the molecular dis-regulation of ceramide could offer a target for treatments and/or prevention of emphysema. ..
  6. Ceramide-induced lung destruction in emphysema
    Irina Petrache; Fiscal Year: 2010
    ..pro-survival sphingosine-1-P will block alveolar apoptosis and thus emphysema. Once understood, the molecular dis-regulation of ceramide could offer a target for treatments and/or prevention of emphysema. ..