Research Topics
Species | I PetracheSummaryAffiliation: Indiana University Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
The involvement of sphingolipids in chronic obstructive pulmonary diseasesIrina Petrache
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
Handb Exp Pharmacol 216:247-64. 2013..This chapter discusses current evidence of sphingolipid perturbations in experimental models of COPD and relevant links to human disease based on translational and epidemiological data...
RTP801 is required for ceramide-induced cell-specific death in the murine lungKrzysztof Kamocki
Department of Biochemistry and Molecular Biology, Indianapolis, IN 46202, USA
Am J Respir Cell Mol Biol 48:87-93. 2013..In conclusion, ceramide and RTP801 participate in alveolar cell apoptosis through a process of mutual up-regulation, which may result in self-amplification loops, leading to alveolar damage...- Involvement of ceramide in cell death responses in the pulmonary circulationIrina Petrache
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Indiana University, Indianapolis, Indiana, USA
Proc Am Thorac Soc 8:492-6. 2011.... - Mechanisms of lung endothelial barrier disruption induced by cigarette smoke: role of oxidative stress and ceramidesKelly S Schweitzer
Department of Medicine, Indiana University School of Medicine, Indianapolis, 46202 5120, USA
Am J Physiol Lung Cell Mol Physiol 301:L836-46. 2011..Amelioration of endothelial permeability may alleviate lung and systemic vascular dysfunction associated with smoking-related chronic obstructive lung diseases... - HIV associated pulmonary emphysema: a review of the literature and inquiry into its mechanismI Petrache
Division of Pulmonary, Allergy, Critical Care and Occupational Medicine, Indiana University, Van Nuys Medical Science Building, 635 Barnhill Drive, MS224, Indianapolis, IN 46202 5120, USA
Thorax 63:463-9. 2008..A better understanding of the pathogenesis of HIV associated pulmonary emphysema may provide clues and therapeutic targets that have broader application in this disease, including cigarette smoke induced emphysema... - Superoxide dismutase protects against apoptosis and alveolar enlargement induced by ceramideIrina Petrache
Division of Pulmonary, Allergy, Critical Care, and Occupational Medicine, Indiana University, Indianapolis, Indiana 46202 5120, USA
Am J Physiol Lung Cell Mol Physiol 295:L44-53. 2008..This work implicates excessive lung ceramides as amplifiers of lung injury through redox-dependent mechanisms... - alpha-1 antitrypsin inhibits caspase-3 activity, preventing lung endothelial cell apoptosisIrina Petrache
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Am J Pathol 169:1155-66. 2006.... 
Ceramide causes pulmonary cell apoptosis and emphysema: a role for sphingolipid homeostasis in the maintenance of alveolar cellsIrina Petrache
Division of Pulmonary, Allergy, Critical Care and Occupational Medicine, Indiana University School of Medicine, Indianapolis, 46202, USA
Proc Am Thorac Soc 3:510. 2006- A novel antiapoptotic role for alpha1-antitrypsin in the prevention of pulmonary emphysemaIrina Petrache
Division of Pulmonary and Critical Care, Department of Medicine, John Hopkins University School of Medicine, Baltimore, Maryland, USA
Am J Respir Crit Care Med 173:1222-8. 2006..The association of alpha1-antitrypsin deficiency with the development of emphysema has supported the concept that protease/antiprotease imbalance mediates cigarette smoke-induced emphysema... - Apoptotic sphingolipid signaling by ceramides in lung endothelial cellsTerry R Medler
Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Am J Respir Cell Mol Biol 38:639-46. 2008..The serine palmitoyl synthase-regulated ceramides synthesis may contribute to the amplification of pulmonary vascular injury induced by excessive ceramides... - Stimulation of sphingosine 1-phosphate signaling as an alveolar cell survival strategy in emphysemaKhalil J Diab
Division of Pulmonary, Allergy, Critical Care, and Occupational Medicine, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202 5120, USA
Am J Respir Crit Care Med 181:344-52. 2010..The effects of increased endogenous ceramides could be offset by sphingosine 1-phosphate (S1P), a prosurvival by-product of ceramide metabolism... - Role of lung maintenance program in the heterogeneity of lung destruction in emphysemaRubin M Tuder
Division of Cardiopulmonary Pathology, Department of Pathology, Ross Research Building, Room 519, 720 Rutland Avenue, Baltimore, MD 21205, USA
Proc Am Thorac Soc 3:673-9. 2006..As injury prevails during the course of this chronic disease, it leads to a more homogeneous pattern of lung disease... - Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in miceTirumalai Rangasamy
Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
J Clin Invest 114:1248-59. 2004..The responsiveness of the Nrf2 pathway may act as a major determinant of susceptibility to tobacco smoke-induced emphysema by upregulating antioxidant defenses and decreasing lung inflammation and alveolar cell apoptosis... - Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke-induced pulmonary injury and emphysemaToshinori Yoshida
Division of Cardiopulmonary Pathology, Department of Pathology, Johns Hopkins University, Baltimore, Maryland, USA
Nat Med 16:767-73. 2010..Our data support the notion that Rtp801 may represent a major molecular sensor and mediator of cigarette smoke-induced lung injury... - Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in miceIrina Petrache
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, 5501 Hopkins Bayview Circle, JHAAC, 4B 65, Baltimore, Maryland 21224, USA
Nat Med 11:491-8. 2005..Finally, increased lung ceramides in individuals with smoking-induced emphysema suggests that ceramide upregulation may be a crucial pathogenic element and a promising target in this disease that currently lacks effective therapies... - State of the art. Cellular and molecular mechanisms of alveolar destruction in emphysema: an evolutionary perspectiveRubin M Tuder
Department of Pathology, Division of Cardiopulmonary Pathology, Ross Research Building, Ross 519, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA
Proc Am Thorac Soc 3:503-10. 2006..An evolutionary perspective of emphysema that incorporates mechanisms related to aging may lead to important advances in the understanding and therapeutic targeting of chronic obstructive pulmonary disease... - CFTR regulation of intracellular pH and ceramides is required for lung endothelial cell apoptosisJulie Noe
Section of Pulmonology and Critical Care, Department of Pediatrics, Indiana University, Indianapolis, Indiana 46202 5120, USA
Am J Respir Cell Mol Biol 41:314-23. 2009..These results may have implications in the pathogenesis of cystic fibrosis, where aberrant endothelial cell death may dysregulate lung vascular homeostasis, contributing to abnormal angiogenesis and chronic inflammation... - Spinal ceramide modulates the development of morphine antinociceptive tolerance via peroxynitrite-mediated nitroxidative stress and neuroimmune activationMichael M Ndengele
Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Saint Louis University School of Medicine, St Louis, MO, USA
J Pharmacol Exp Ther 329:64-75. 2009.... - Differential effect of MLC kinase in TNF-alpha-induced endothelial cell apoptosis and barrier dysfunctionI Petrache
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Am J Physiol Lung Cell Mol Physiol 280:L1168-78. 2001..These studies indicate a central role for the endothelial cell cytoskeleton in TNF-alpha-mediated apoptosis, whereas TNF-alpha-induced vascular permeability appears to evolve independently of contractile tension generation... - Pulmonary ischemia induces lung remodeling and angiogenesisElizabeth M Wagner
Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
J Appl Physiol 100:587-93. 2006..Because sham surgeries had little effect on measured parameters, we conclude that both thoracic wound healing and pulmonary ischemia are required for systemic neovascularization... - Mechanism of alpha-1 antitrypsin endocytosis by lung endotheliumSadaf Sohrab
Department of Medicine, Division of Pulmonary, Allergy, Critical Care and Occupational Medicine, Indiana University, Indianapolis, IN 46202, USA
FASEB J 23:3149-58. 2009..Our results suggest that clathrin-mediated endocytosis regulates A1AT intracellular function in the lung endothelium and may be an important determinant of the serpin's protection against developing cigarette smoke-induced emphysema... - Anti-type V collagen humoral immunity in lung transplant primary graft dysfunctionTakekazu Iwata
Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
J Immunol 181:5738-47. 2008..This study demonstrates a major role for anti-col(V) humoral immunity in PGD, and identifies the airway epithelium as a target in PGD... - Apoptosis and emphysema: the missing linkRubin M Tuder
Division of Cardiopulmonary Pathology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Am J Respir Cell Mol Biol 28:551-4. 2003 - Adipose stem cell treatment in mice attenuates lung and systemic injury induced by cigarette smokingKelly S Schweitzer
Division of Pulmonary and Critical Care Medicine, Indiana University, Indianapolis, IN 46202 5120, USA
Am J Respir Crit Care Med 183:215-25. 2011..Adipose-derived stem cells express multiple growth factors that inhibit endothelial cell apoptosis, and demonstrate substantial pulmonary trapping after intravascular delivery... - The role of the microtubules in tumor necrosis factor-alpha-induced endothelial cell permeabilityIrina Petrache
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Am J Respir Cell Mol Biol 28:574-81. 2003..These results strongly suggest the involvement of microtubule rearrangement in TNF-alpha-induced endothelial cell permeability via p38 mitogen-activated protein kinase activation... - Molecular multitasking in the airspace: alpha1-antitrypsin takes on thrombin and plasminRubin M Tuder
Am J Respir Cell Mol Biol 37:130-4. 2007
Research Grants
- CYTOSKELETAL REGULATION OF ENDOTHELIAL CELL APOPTOSISIrina Petrache; Fiscal Year: 2004..abstract_text> ..
- Ceramide-induced lung destruction in emphysemaIrina Petrache; Fiscal Year: 2009..pro-survival sphingosine-1-P will block alveolar apoptosis and thus emphysema. Once understood, the molecular dis-regulation of ceramide could offer a target for treatments and/or prevention of emphysema. ..
- Ceramide-induced lung destruction in emphysemaIrina Petrache; Fiscal Year: 2010..pro-survival sphingosine-1-P will block alveolar apoptosis and thus emphysema. Once understood, the molecular dis-regulation of ceramide could offer a target for treatments and/or prevention of emphysema. ..