Research Topics
Genomes and Genes
| Munro PeacockSummaryAffiliation: Indiana University Country: USA Publications
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Detail Information
Publications
Sex-specific and non-sex-specific quantitative trait loci contribute to normal variation in bone mineral density in menMunro Peacock
Department of Medicine, Indiana University School of Medicine, University Hospital and Out Patient Center, 550 North University Boulevard, Room 5595, Indianapolis, Indiana 46202 5250, USA
J Clin Endocrinol Metab 90:3060-6. 2005..There are few comparable data in men. This study in men aimed to establish the heritability of peak BMD, identify QTL contributing to normal variation in BMD, and determine which QTL might be sex specific...- Peak bone mineral density at the hip is linked to chromosomes 14q and 15qMunro Peacock
Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Osteoporos Int 15:489-96. 2004..Principal component had comparable LOD scores with those of the component phenotypes suggesting pleiotropic effects of these genes on hip phenotypes... 
Race and sex differences in bone mineral density and geometry at the femurM Peacock
Department of Medicine, Indiana University School of Medicine, USA
Bone 45:218-25. 2009..The aim of this study was to quantify differences in femoral bone density and geometry between a large sample of healthy American white and black women and men...- Bone mineral density variation in men is influenced by sex-specific and non sex-specific quantitative trait lociMunro Peacock
Department of Medicine, Indiana University School of Medicine, USA
Bone 45:443-8. 2009..The aim of this study was to perform a genome wide scan in healthy men to identify quantitative trait loci (QTL) that were significantly linked to aBMD and to test whether any of these might be sex-specific... - Cinacalcet hydrochloride maintains long-term normocalcemia in patients with primary hyperparathyroidismMunro Peacock
Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
J Clin Endocrinol Metab 90:135-41. 2005..Cinacalcet rapidly normalizes serum calcium and reduces PTH in patients with primary HPT, and these effects are maintained with long-term treatment. Cinacalcet may be an effective, nonsurgical approach for management of primary HPT... 
Cinacalcet treatment of primary hyperparathyroidism: biochemical and bone densitometric outcomes in a five-year studyMunro Peacock
Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
J Clin Endocrinol Metab 94:4860-7. 2009..Primary hyperparathyroidism (PHPT) is characterized by chronically elevated serum calcium and inappropriately normal or increased PTH...- Genetics of osteoporosisMunro Peacock
Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Endocr Rev 23:303-26. 2002..As with all genetic studies in humans, these scientific advances will need to be made in an environment of legal and ethical safeguards that are acceptable to the general public... - Calcium metabolism in health and diseaseMunro Peacock
Indiana University Medical School, Indianapolis, Indiana, USA
Clin J Am Soc Nephrol 5:S23-30. 2010..Further research is needed to elucidate the risks and mechanisms of soft tissue calcification with calcium supplementation in both healthy subjects and CKD-MBD patients... - Sex-specific quantitative trait loci contribute to normal variation in bone structure at the proximal femur in menMunro Peacock
Department of Medicine, Indiana University School of Medicine, University Hospital and Out Patient Center, 550 N University Boulevard, Room 5595, Indianapolis, IN 46202 5250, USA
Bone 37:467-73. 2005..The occurrence of sex-specific genes in humans for bone structure has important implications for the pathogenesis and treatment of osteoporosis... - Cinacalcet HCl reduces hypercalcemia in primary hyperparathyroidism across a wide spectrum of disease severityMunro Peacock
Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
J Clin Endocrinol Metab 96:E9-18. 2011..Primary hyperparathyroidism (PHPT) is characterized by elevated serum calcium (Ca) and increased PTH concentrations... - Clinical effects of calcimimetics in hyperparathyroidismM Peacock
Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
J Musculoskelet Neuronal Interact 4:414-5. 2004 - Asymptomatic primary hyperparathyroidism: to treat or not to treat?M Peacock
Department of Medicine, Indiana University School of Medicine, University Hospital and Out Patient Center, 550 N, University Boulevard, Room 5595, Indianapolis, IN 46202 5250, USA
Ann Endocrinol (Paris) 67:157-9. 2006 - Serum leptin, parathyroid hormone, 1,25-dihydroxyvitamin D, fibroblast growth factor 23, bone alkaline phosphatase, and sclerostin relationships in obesityElizabeth Grethen
Division of Endocrinology and Metabolism, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
J Clin Endocrinol Metab 97:1655-62. 2012..Obesity is associated with hyperparathyroidism and increased bone mass and turnover, but their pathogeneses are unclear... - Association of adenylate cyclase 10 (ADCY10) polymorphisms and bone mineral density in healthy adultsShoji Ichikawa
Department of Medicine, Indiana University School of Medicine, 541 North Clinical Drive, Clinical Building 459, Indianapolis, IN 46202 5121, USA
Calcif Tissue Int 84:97-102. 2009..However, adjacent SNPs did not corroborate the association in either men or women. In conclusion, we found a modest association between an ADCY10 polymorphism and the spinal areal BMD in premenopausal white women... - Genome-wide association study of bone mineral density in premenopausal European-American women and replication in African-American womenDaniel L Koller
Departments of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
J Clin Endocrinol Metab 95:1802-9. 2010..Several genome-wide association studies (GWAS) have been performed to identify genes contributing to bone mineral density (BMD), typically in samples of elderly women and men... - Vitamin D and hyperparathyroidism in obesityElizabeth Grethen
Division of Endocrinology and Metabolism, Indiana University School of Medicine, Indianapolis, Indiana 46202 5111, USA
J Clin Endocrinol Metab 96:1320-6. 2011..Low vitamin D status and hyperparathyroidism occur in obesity and may be involved in pathogenesis of obesity-associated comorbid conditions... - Replication of previous genome-wide association studies of bone mineral density in premenopausal American womenShoji Ichikawa
Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
J Bone Miner Res 25:1821-9. 2010.... - Polymorphisms in the estrogen receptor beta (ESR2) gene are associated with bone mineral density in Caucasian men and womenShoji Ichikawa
Department of Medicine, Indiana University School of Medicine, 541 North Clinical Drive, Clinical Building 459, Indianapolis, Indiana 46202 5121, USA
J Clin Endocrinol Metab 90:5921-7. 2005..Recently, we identified significant linkage for hip BMD in premenopausal sister pairs at chromosome 14q (LOD score = 3.5), where the estrogen receptor beta gene (ESR2) is located... - CLCN7 polymorphisms and bone mineral density in healthy premenopausal white women and in white menKang Chu
Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Bone 43:995-8. 2008..However, there is no study to date that has examined whether CLCN7 polymorphisms underlie normal variation of peak BMD in healthy premenopausal white women and in white men... - False positive rates in association studies as a function of degree of stratificationDaniel L Koller
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202 5251, USA
J Bone Miner Res 19:1291-5. 2004..The rate of positive results doubled as the proportion of stratification increased, showing the importance of controlling for stratification in association studies... - Heritability of changes in bone size and bone mass with age in premenopausal white sistersSiu L Hui
Department of Medicine, Indiana University School of Medicine, Indianapolis, USA
J Bone Miner Res 21:1121-5. 2006..Femoral neck area expands and BMD decreases in premenopausal women. We used longitudinal DXA measurements on 388 premenopausal white sisters to show significant heritability of the rates of change in femoral neck area, BMC, and BMD... - Human ALOX12, but not ALOX15, is associated with BMD in white men and womenShoji Ichikawa
Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202 5121, USA
J Bone Miner Res 21:556-64. 2006..Polymorphisms in human ALOX12, but not ALOX15, were significantly associated with spine BMD in white men and women, suggesting that ALOX12 may contribute to normal variation in BMD... - Identification of a linkage disequilibrium block in chromosome 1q associated with BMD in premenopausal white womenShoji Ichikawa
Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202 5121, USA
J Bone Miner Res 23:1680-8. 2008.... - Confirmation of linkage to chromosome 1q for peak vertebral bone mineral density in premenopausal white womenMichael J Econs
Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, USA
Am J Hum Genet 74:223-8. 2004..Studies are now ongoing to identify the gene(s) contributing to peak spine BMD in women... - Difference in bone mass between black and white American children: attributable to body build, sex hormone levels, or bone turnover?Siu L Hui
Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
J Clin Endocrinol Metab 88:642-9. 2003..The residual racial differences in bone mass were not statistically significant... - Summary statement from a workshop on asymptomatic primary hyperparathyroidism: a perspective for the 21st centuryJohn P Bilezikian
Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
J Clin Endocrinol Metab 87:5353-61. 2002 - Sibling pair linkage and association studies between peak bone mineral density and the gene locus for the osteoclast-specific subunit (OC116) of the vacuolar proton pump on chromosome 11p12-13Gwenaelle Carn
Departments of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
J Clin Endocrinol Metab 87:3819-24. 2002..Therefore, our linkage data suggest that the chromosomal region that contains OC116 harbors a gene that affects peak BMD, but our association results indicate that polymorphisms in the OC116 gene do not affect peak BMD... - The calcimimetic cinacalcet normalizes serum calcium in subjects with primary hyperparathyroidismDolores M Shoback
Department of Medicine, Veterans Affairs Medical Center, University of California San Francisco, San Francisco, California 94121, USA
J Clin Endocrinol Metab 88:5644-9. 2003.... - Primary hyperparathyroidism and the kidney: biochemical and clinical spectrumMunro Peacock
Department of Medicine, Indiana University School of Medicine, Indianapolis, USA
J Bone Miner Res 17:N87-94. 2002..Risk factors for nephrocalcinosis are not clearly defined. Parathyroidectomy greatly reduces the incidence of nephrolithiasis but has little effect on nephrocalcinosis... - Common genetic determinants of vitamin D insufficiency: a genome-wide association studyThomas J Wang
Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
Lancet 376:180-8. 2010..We aimed to identify common genetic variants affecting vitamin D concentrations and risk of insufficiency... - Contribution of the LRP5 gene to normal variation in peak BMD in womenDaniel L Koller
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
J Bone Miner Res 20:75-80. 2005..Association between SNPs in LRP5 and hip and spine BMD was measured in 1301 premenopausal women. Only a small proportion of the BMD variation was attributable to LRP5 in our sample... - Velocities of bone mineral accrual in black and white American childrenSiu L Hui
Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
J Bone Miner Res 25:1527-35. 2010..It is due to black children's higher rate of bone mineral accrual in prepuberty and plausibly in postpuberty. Most of the racial difference in TBMC velocity can be explained by growth in size... - Bone loss at the femoral neck in premenopausal white women: effects of weight change and sex-hormone levelsSiu L Hui
Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
J Clin Endocrinol Metab 87:1539-43. 2002..In summary, femoral neck BMD decreases in premenopausal women, particularly those with lower levels of estrogens resulting from slowing ovarian function despite regular menses. This decrease can be offset by more rapid weight gain... - Iron modifies plasma FGF23 differently in autosomal dominant hypophosphatemic rickets and healthy humansErik A Imel
Department of Medicine, Indiana University School of Medicine, 541 North Clinical Drive, CL 459, Indianapolis, Indiana 46202, USA
J Clin Endocrinol Metab 96:3541-9. 2011..The clinical phenotype includes variable onset during childhood or adulthood and waxing/waning of hypophosphatemia. Delayed onset after puberty in females suggests iron status may be important... - Serum markers of bone turnover are increased at six and 18 months after Roux-en-Y bariatric surgery: correlation with the reduction in leptinCarolina Bruno
Indiana University School of Medicine, 541 North Clinical Drive, Clinical Building 455, Indianapolis, Indiana 46202 5111
J Clin Endocrinol Metab 95:159-66. 2010..The aim of the study was to examine serum markers of bone turnover at 6 and 18 months after Roux-en-Y gastric bypass surgery... - Iron deficiency drives an autosomal dominant hypophosphatemic rickets (ADHR) phenotype in fibroblast growth factor-23 (Fgf23) knock-in miceEmily G Farrow
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Proc Natl Acad Sci U S A 108:E1146-55. 2011.... - Summary statement from a workshop on asymptomatic primary hyperparathyroidism: a perspective for the 21st centuryJohn P Bilezikian
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
J Bone Miner Res 17:N2-11. 2002 - Linkage of structure at the proximal femur to chromosomes 3, 7, 8, and 19D L Koller
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
J Bone Miner Res 18:1057-65. 2003..0); and on chromosome 8, to femoral head width (LOD = 6.0). The current findings emphasize the importance of increasing sample size to replicate linkage findings and identify new regions of linkage... - A comparison of oral and intravenous bisphosphonate therapy for children with osteogenesis imperfectaL A Dimeglio
Department of Pediatrics, Section of Pediatric Endocrinology and Diabetology, Indiana University School of Medicine, Indianapolis, IN, USA
J Pediatr Endocrinol Metab 18:43-53. 2005..All children had a decrease in biochemical markers of bone turnover. Linear growth showed a moderate increase above that for age. There was a non-significant decrease in fracture incidence in both groups... - Association studies of ALOX5 and bone mineral density in healthy adultsT Foroud
Indiana University School of Medicine, Health Information and Translational Sciences Building, Indianapolis, IN 46202 3002, USA
Osteoporos Int 19:637-43. 2008..We tested this hypothesis in a sample of healthy men and women and did not find consistent evidence for an association between variation in this gene and either lumbar spine or femoral neck BMD... - Intravenous pamidronate treatment of children under 36 months of age with osteogenesis imperfectaL A Dimeglio
Department of Pediatrics, Section of Pediatric Endocrinology and Diabetology, Indiana University School of Medicine, Indianapolis, IN, USA
Bone 35:1038-45. 2004..To examine this, we instituted a prospective clinical trial of intravenous bisphosphonate to study safety, feasibility, and efficacy of this therapy... - Sensitivity of fibroblast growth factor 23 measurements in tumor-induced osteomalaciaErik A Imel
Indiana University School of Medicine, 541 North Clinical Drive, Clinical Building 459, Indianapolis, Indianapolis 46202, USA
J Clin Endocrinol Metab 91:2055-61. 2006..Normal FGF23 concentrations should be interpreted in relation to the serum phosphate and 1,25-dihydryxyvitamin-D concentrations... - Two-year clinical trial of oral alendronate versus intravenous pamidronate in children with osteogenesis imperfectaLinda A DiMeglio
Department of Pediatrics, Section of Pediatric Endocrinology and Diabetology, Indiana University School of Medicine, Indianapolis, Indiana, USA
J Bone Miner Res 21:132-40. 2006..Children with mild OI had greater responses than severe OI in BMD and growth... - Bone turnover is not influenced by serum 25-hydroxyvitamin D in pubertal healthy black and white childrenKathleen M Hill
Indiana University School of Medicine, Department of Medicine, Division of Endocrinology, 541 N Clinical Drive, Indianapolis, IN 46202 5111, USA
Bone 51:795-9. 2012..The lack of association was not affected by race, sex, latitude, or baseline serum 25 (OH) D. Serum 25 (OH) D in the range of 10-46 ng/mL appears to be sufficient for normal bone turnover in healthy black and white pubertal adolescents... - Genome screen for QTLs contributing to normal variation in bone mineral density and osteoporosisD L Koller
Indiana University School of Medicine, Indianapolis 46202, USA
J Clin Endocrinol Metab 85:3116-20. 2000..Our study is the largest genome screen to date for genes underlying variations in peak BMD and represents an important step toward identifying genes contributing to osteoporosis in the general population... - Polymorphisms in the bone morphogenetic protein 2 (BMP2) gene do not affect bone mineral density in white men or womenS Ichikawa
Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
Osteoporos Int 17:587-92. 2006..Recently, bone morphogenetic protein 2 (BMP2) was reported as a susceptibility gene for osteoporotic fractures and low BMD in Icelandic and Danish populations... - Genome screen for quantitative trait loci underlying normal variation in femoral structureD L Koller
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis 46202, USA
J Bone Miner Res 16:985-91. 2001..8). This study is the first genome screen for loci underlying variation in femoral structure and represents an important step toward identifying genes contributing to the risk of osteoporotic hip fracture in the general population... - Differences in muscle endurance and recovery between fallers and nonfallers, and between young and older womenK I Schwendner
School of Medicine, Indiana University, Indianapolis, USA
J Gerontol A Biol Sci Med Sci 52:M155-60. 1997..Significant morbidity and mortality are associated with falls in older adults. We tested the hypothesis that older women with a history of falls demonstrate decreased muscle endurance and longer recovery times following fatiguing exercise... - Variability in skeletal mass, structure, and biomechanical properties among inbred strains of ratsC H Turner
Department of Orthopedic Surgery, Indiana University School of Medicine, Indianapolis, USA
J Bone Miner Res 16:1532-9. 2001..The results strongly suggest that selected crosses of inbred strains of rats will provide useful models for studying genetic influences on bone strength and structure... - Dietary calcium intake protects women consuming oral contraceptives from spine and hip bone lossDorothy Teegarden
Interdepartmental Nutrition Program, 700 West State Street, Stone Hall 1264, Purdue University, West Lafayette, Indiana 47907, USA
J Clin Endocrinol Metab 90:5127-33. 2005..It is estimated that 80% of all women have used oral contraceptives (OCP), but OCP use may prevent attainment of maximal peak bone mass in young women and thus increase the risk of osteoporosis later in life... - The effect of soy protein and soy isoflavones on calcium metabolism in postmenopausal women: a randomized crossover studyLisa A Spence
Department of Foods and Nutrition, Purdue University, West Lafayette, IN, USA
Am J Clin Nutr 81:916-22. 2005..This finding reinforces the importance of evaluating all aspects of calcium metabolism. Soy isoflavones did not significantly affect calcium metabolism... - Racial differences in calcium retention in response to dietary salt in adolescent girlsKarin Wigertz
Departments of Foods and Nutrition and of Statistics, Purdue University, West Lafayette, IN, USA
Am J Clin Nutr 81:845-50. 2005..05). CONCLUSIONS: Calcium retention is significantly greater in black girls than in white girls but is significantly reduced in girls of both races in response to salt loading... - Dairy intakes affect bone density in the elderlyLinda D McCabe
Purdue University, West Lafayette, IN, USA
Am J Clin Nutr 80:1066-74. 2004..Calcium supplementation protected both men and women from bone loss in the longitudinal study of whites... - Denosumab in postmenopausal women with low bone mineral densityMichael R McClung
Providence Portland Medical Center, Portland, Oreg, USA
N Engl J Med 354:821-31. 2006..The fully human monoclonal antibody denosumab (formerly known as AMG 162) binds RANKL with high affinity and specificity and inhibits RANKL action... - Racial differences in skeletal calcium retention in adolescent girls with varied controlled calcium intakesMichelle Braun
Department of Foods and Nutrition, Purdue University, West Lafayette, IN 47907, USA
Am J Clin Nutr 85:1657-63. 2007..Higher bone mass in blacks than in whites has been related to greater calcium utilization efficiency. Dietary calcium requirements for maximal skeletal calcium accretion during puberty may differ between the races... - Meta-analysis of genome-wide scans provides evidence for sex- and site-specific regulation of bone massJohn P A Ioannidis
Department of Hygiene and Epidemology, University of Ioannina School of Medicine, Ioannina, Greece
J Bone Miner Res 22:173-83. 2007..Evidence was gained to suggest that several chromosomal loci regulate BMD in a site-specific and sex-specific manner... - Sodium retention in black and white female adolescents in response to salt intakeCristina Palacios
Department of Foods and Nutrition, Purdue University, West Lafayette, Indiana 47907, USA
J Clin Endocrinol Metab 89:1858-63. 2004..In summary, black girls showed greater Na(+) retention compared with white girls. The difference in Na(+) handling may contribute to underlying racial differences in susceptibility to hypertension... - Fat oxidation and its relation to serum parathyroid hormone in young women enrolled in a 1-y dairy calcium interventionCarolyn W Gunther
Department of Foods and Nutrition, Purdue University, West Lafayette, IN 47907-1264, USA
Am J Clin Nutr 82:1228-34. 2005..CONCLUSIONS: The results suggest that a chronic diet high in dairy calcium increases whole-body fat oxidation from a meal, and increases in fasting serum PTH relate to decreases in postprandial whole-body fat oxidation... - Calcium retention in adolescent boys on a range of controlled calcium intakesMichelle Braun
Purdue University, West Lafayette, IN, USA
Am J Clin Nutr 84:414-8. 2006..CONCLUSION: The higher calcium retention in boys than in girls was attained through higher net calcium absorption and lower urinary excretion than in girls... - Effect of 1-year dairy product intervention on fat mass in young women: 6-month follow-upMarianne S Eagan
Department of Foods and Nutrition, Purdue University, 1264 Stone Hall, 700 West State Street, West Lafayette, IN 47907, USA
Obesity (Silver Spring) 14:2242-8. 2006..DISCUSSION: Dietary calcium intake over 18 months predicted a negative change in body fat mass. Thus, increased dietary calcium intakes through dairy products may prevent fat mass accumulation in young, healthy, normal-weight women... - Dairy products do not lead to alterations in body weight or fat mass in young women in a 1-y interventionCarolyn W Gunther
Departments of Foods and Nutrition, Purdue University, West Lafayette, IN, USA
Am J Clin Nutr 81:751-6. 2005..5 +/- 2.5, 0.3 +/- 2.7, and 0.5 +/- 3.5 kg, respectively; P = 0.26). CONCLUSION: Increased intake of dairy products does not alter body weight or fat mass in young, healthy women over 1 y...