Munro Peacock

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. pmc Effect of denosumab on bone mineral density and biochemical markers of bone turnover: 8-year results of a phase 2 clinical trial
    M R McClung
    Oregon Osteoporosis Center, 5050 NE Hoyt Street, Suite 626, Portland, OR 97213, USA
    Osteoporos Int 24:227-35. 2013
  2. pmc Race and sex differences in bone mineral density and geometry at the femur
    M Peacock
    Department of Medicine, Indiana University School of Medicine, USA
    Bone 45:218-25. 2009
  3. pmc Bone mineral density variation in men is influenced by sex-specific and non sex-specific quantitative trait loci
    Munro Peacock
    Department of Medicine, Indiana University School of Medicine, USA
    Bone 45:443-8. 2009
  4. pmc Cinacalcet HCl reduces hypercalcemia in primary hyperparathyroidism across a wide spectrum of disease severity
    Munro Peacock
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Clin Endocrinol Metab 96:E9-18. 2011
  5. ncbi request reprint Peak bone mineral density at the hip is linked to chromosomes 14q and 15q
    Munro Peacock
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Osteoporos Int 15:489-96. 2004
  6. ncbi request reprint Clinical effects of calcimimetics in hyperparathyroidism
    M Peacock
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Musculoskelet Neuronal Interact 4:414-5. 2004
  7. pmc Sex-specific quantitative trait loci contribute to normal variation in bone structure at the proximal femur in men
    Munro Peacock
    Department of Medicine, Indiana University School of Medicine, University Hospital and Out Patient Center, 550 N University Boulevard, Room 5595, Indianapolis, IN 46202 5250, USA
    Bone 37:467-73. 2005
  8. ncbi request reprint Sex-specific and non-sex-specific quantitative trait loci contribute to normal variation in bone mineral density in men
    Munro Peacock
    Department of Medicine, Indiana University School of Medicine, University Hospital and Out Patient Center, 550 North University Boulevard, Room 5595, Indianapolis, Indiana 46202 5250, USA
    J Clin Endocrinol Metab 90:3060-6. 2005
  9. ncbi request reprint Cinacalcet hydrochloride maintains long-term normocalcemia in patients with primary hyperparathyroidism
    Munro Peacock
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Clin Endocrinol Metab 90:135-41. 2005
  10. ncbi request reprint Genetics of osteoporosis
    Munro Peacock
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Endocr Rev 23:303-26. 2002

Detail Information

Publications67

  1. pmc Effect of denosumab on bone mineral density and biochemical markers of bone turnover: 8-year results of a phase 2 clinical trial
    M R McClung
    Oregon Osteoporosis Center, 5050 NE Hoyt Street, Suite 626, Portland, OR 97213, USA
    Osteoporos Int 24:227-35. 2013
    ..Denosumab treatment was well tolerated throughout the 8-year study...
  2. pmc Race and sex differences in bone mineral density and geometry at the femur
    M Peacock
    Department of Medicine, Indiana University School of Medicine, USA
    Bone 45:218-25. 2009
    ..The aim of this study was to quantify differences in femoral bone density and geometry between a large sample of healthy American white and black women and men...
  3. pmc Bone mineral density variation in men is influenced by sex-specific and non sex-specific quantitative trait loci
    Munro Peacock
    Department of Medicine, Indiana University School of Medicine, USA
    Bone 45:443-8. 2009
    ..The aim of this study was to perform a genome wide scan in healthy men to identify quantitative trait loci (QTL) that were significantly linked to aBMD and to test whether any of these might be sex-specific...
  4. pmc Cinacalcet HCl reduces hypercalcemia in primary hyperparathyroidism across a wide spectrum of disease severity
    Munro Peacock
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Clin Endocrinol Metab 96:E9-18. 2011
    ..Primary hyperparathyroidism (PHPT) is characterized by elevated serum calcium (Ca) and increased PTH concentrations...
  5. ncbi request reprint Peak bone mineral density at the hip is linked to chromosomes 14q and 15q
    Munro Peacock
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Osteoporos Int 15:489-96. 2004
    ..Principal component had comparable LOD scores with those of the component phenotypes suggesting pleiotropic effects of these genes on hip phenotypes...
  6. ncbi request reprint Clinical effects of calcimimetics in hyperparathyroidism
    M Peacock
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Musculoskelet Neuronal Interact 4:414-5. 2004
  7. pmc Sex-specific quantitative trait loci contribute to normal variation in bone structure at the proximal femur in men
    Munro Peacock
    Department of Medicine, Indiana University School of Medicine, University Hospital and Out Patient Center, 550 N University Boulevard, Room 5595, Indianapolis, IN 46202 5250, USA
    Bone 37:467-73. 2005
    ..The occurrence of sex-specific genes in humans for bone structure has important implications for the pathogenesis and treatment of osteoporosis...
  8. ncbi request reprint Sex-specific and non-sex-specific quantitative trait loci contribute to normal variation in bone mineral density in men
    Munro Peacock
    Department of Medicine, Indiana University School of Medicine, University Hospital and Out Patient Center, 550 North University Boulevard, Room 5595, Indianapolis, Indiana 46202 5250, USA
    J Clin Endocrinol Metab 90:3060-6. 2005
    ..There are few comparable data in men. This study in men aimed to establish the heritability of peak BMD, identify QTL contributing to normal variation in BMD, and determine which QTL might be sex specific...
  9. ncbi request reprint Cinacalcet hydrochloride maintains long-term normocalcemia in patients with primary hyperparathyroidism
    Munro Peacock
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Clin Endocrinol Metab 90:135-41. 2005
    ..Cinacalcet rapidly normalizes serum calcium and reduces PTH in patients with primary HPT, and these effects are maintained with long-term treatment. Cinacalcet may be an effective, nonsurgical approach for management of primary HPT...
  10. ncbi request reprint Genetics of osteoporosis
    Munro Peacock
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Endocr Rev 23:303-26. 2002
    ..As with all genetic studies in humans, these scientific advances will need to be made in an environment of legal and ethical safeguards that are acceptable to the general public...
  11. ncbi request reprint Asymptomatic primary hyperparathyroidism: to treat or not to treat?
    M Peacock
    Department of Medicine, Indiana University School of Medicine, University Hospital and Out Patient Center, 550 N, University Boulevard, Room 5595, Indianapolis, IN 46202 5250, USA
    Ann Endocrinol (Paris) 67:157-9. 2006
  12. doi request reprint Calcium metabolism in health and disease
    Munro Peacock
    Indiana University Medical School, Indianapolis, Indiana, USA
    Clin J Am Soc Nephrol 5:S23-30. 2010
    ..Further research is needed to elucidate the risks and mechanisms of soft tissue calcification with calcium supplementation in both healthy subjects and CKD-MBD patients...
  13. doi request reprint Cinacalcet treatment of primary hyperparathyroidism: biochemical and bone densitometric outcomes in a five-year study
    Munro Peacock
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Clin Endocrinol Metab 94:4860-7. 2009
    ..Primary hyperparathyroidism (PHPT) is characterized by chronically elevated serum calcium and inappropriately normal or increased PTH...
  14. pmc Serum leptin, parathyroid hormone, 1,25-dihydroxyvitamin D, fibroblast growth factor 23, bone alkaline phosphatase, and sclerostin relationships in obesity
    Elizabeth Grethen
    Division of Endocrinology and Metabolism, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Clin Endocrinol Metab 97:1655-62. 2012
    ..Obesity is associated with hyperparathyroidism and increased bone mass and turnover, but their pathogeneses are unclear...
  15. pmc Genome-wide association study of bone mineral density in premenopausal European-American women and replication in African-American women
    Daniel L Koller
    Departments of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Clin Endocrinol Metab 95:1802-9. 2010
    ..Several genome-wide association studies (GWAS) have been performed to identify genes contributing to bone mineral density (BMD), typically in samples of elderly women and men...
  16. pmc Association of adenylate cyclase 10 (ADCY10) polymorphisms and bone mineral density in healthy adults
    Shoji Ichikawa
    Department of Medicine, Indiana University School of Medicine, 541 North Clinical Drive, Clinical Building 459, Indianapolis, IN 46202 5121, USA
    Calcif Tissue Int 84:97-102. 2009
    ..However, adjacent SNPs did not corroborate the association in either men or women. In conclusion, we found a modest association between an ADCY10 polymorphism and the spinal areal BMD in premenopausal white women...
  17. pmc Vitamin D and hyperparathyroidism in obesity
    Elizabeth Grethen
    Division of Endocrinology and Metabolism, Indiana University School of Medicine, Indianapolis, Indiana 46202 5111, USA
    J Clin Endocrinol Metab 96:1320-6. 2011
    ..Low vitamin D status and hyperparathyroidism occur in obesity and may be involved in pathogenesis of obesity-associated comorbid conditions...
  18. pmc Polymorphisms in the estrogen receptor beta (ESR2) gene are associated with bone mineral density in Caucasian men and women
    Shoji Ichikawa
    Department of Medicine, Indiana University School of Medicine, 541 North Clinical Drive, Clinical Building 459, Indianapolis, Indiana 46202 5121, USA
    J Clin Endocrinol Metab 90:5921-7. 2005
    ..Recently, we identified significant linkage for hip BMD in premenopausal sister pairs at chromosome 14q (LOD score = 3.5), where the estrogen receptor beta gene (ESR2) is located...
  19. pmc Replication of previous genome-wide association studies of bone mineral density in premenopausal American women
    Shoji Ichikawa
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    J Bone Miner Res 25:1821-9. 2010
    ....
  20. doi request reprint Oral calcium carbonate affects calcium but not phosphorus balance in stage 3-4 chronic kidney disease
    Kathleen M Hill
    Department of Medicine Division of Endocrinology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Kidney Int 83:959-66. 2013
    ..Thus, the positive calcium balance produced by calcium carbonate treatment within 3 weeks cautions against its use as a phosphate binder in patients with stage 3 or 4 CKD, if these findings can be extrapolated to long-term therapy...
  21. pmc CLCN7 polymorphisms and bone mineral density in healthy premenopausal white women and in white men
    Kang Chu
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Bone 43:995-8. 2008
    ..However, there is no study to date that has examined whether CLCN7 polymorphisms underlie normal variation of peak BMD in healthy premenopausal white women and in white men...
  22. ncbi request reprint False positive rates in association studies as a function of degree of stratification
    Daniel L Koller
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202 5251, USA
    J Bone Miner Res 19:1291-5. 2004
    ..The rate of positive results doubled as the proportion of stratification increased, showing the importance of controlling for stratification in association studies...
  23. ncbi request reprint Human ALOX12, but not ALOX15, is associated with BMD in white men and women
    Shoji Ichikawa
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202 5121, USA
    J Bone Miner Res 21:556-64. 2006
    ..Polymorphisms in human ALOX12, but not ALOX15, were significantly associated with spine BMD in white men and women, suggesting that ALOX12 may contribute to normal variation in BMD...
  24. ncbi request reprint Heritability of changes in bone size and bone mass with age in premenopausal white sisters
    Siu L Hui
    Department of Medicine, Indiana University School of Medicine, Indianapolis, USA
    J Bone Miner Res 21:1121-5. 2006
    ..Femoral neck area expands and BMD decreases in premenopausal women. We used longitudinal DXA measurements on 388 premenopausal white sisters to show significant heritability of the rates of change in femoral neck area, BMC, and BMD...
  25. pmc Confirmation of linkage to chromosome 1q for peak vertebral bone mineral density in premenopausal white women
    Michael J Econs
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, USA
    Am J Hum Genet 74:223-8. 2004
    ..Studies are now ongoing to identify the gene(s) contributing to peak spine BMD in women...
  26. ncbi request reprint Difference in bone mass between black and white American children: attributable to body build, sex hormone levels, or bone turnover?
    Siu L Hui
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Clin Endocrinol Metab 88:642-9. 2003
    ..The residual racial differences in bone mass were not statistically significant...
  27. ncbi request reprint Summary statement from a workshop on asymptomatic primary hyperparathyroidism: a perspective for the 21st century
    John P Bilezikian
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Clin Endocrinol Metab 87:5353-61. 2002
  28. pmc Identification of a linkage disequilibrium block in chromosome 1q associated with BMD in premenopausal white women
    Shoji Ichikawa
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202 5121, USA
    J Bone Miner Res 23:1680-8. 2008
    ....
  29. ncbi request reprint The calcimimetic cinacalcet normalizes serum calcium in subjects with primary hyperparathyroidism
    Dolores M Shoback
    Department of Medicine, Veterans Affairs Medical Center, University of California San Francisco, San Francisco, California 94121, USA
    J Clin Endocrinol Metab 88:5644-9. 2003
    ....
  30. ncbi request reprint Sibling pair linkage and association studies between peak bone mineral density and the gene locus for the osteoclast-specific subunit (OC116) of the vacuolar proton pump on chromosome 11p12-13
    Gwenaelle Carn
    Departments of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Clin Endocrinol Metab 87:3819-24. 2002
    ..Therefore, our linkage data suggest that the chromosomal region that contains OC116 harbors a gene that affects peak BMD, but our association results indicate that polymorphisms in the OC116 gene do not affect peak BMD...
  31. ncbi request reprint SIBLING family genes and bone mineral density: association and allele-specific expression in humans
    Imranul Alam
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA Electronic address
    Bone 64:166-72. 2014
    ..Further studies are necessary to identify the functional variants and to determine the mechanisms underlying the differences in ASE and how these differences relate to the pathophysiology of osteoporosis. ..
  32. pmc Iron modifies plasma FGF23 differently in autosomal dominant hypophosphatemic rickets and healthy humans
    Erik A Imel
    Department of Medicine, Indiana University School of Medicine, 541 North Clinical Drive, CL 459, Indianapolis, Indiana 46202, USA
    J Clin Endocrinol Metab 96:3541-9. 2011
    ..The clinical phenotype includes variable onset during childhood or adulthood and waxing/waning of hypophosphatemia. Delayed onset after puberty in females suggests iron status may be important...
  33. ncbi request reprint Bone turnover is not influenced by serum 25-hydroxyvitamin D in pubertal healthy black and white children
    Kathleen M Hill
    Indiana University School of Medicine, Department of Medicine, Division of Endocrinology, 541 N Clinical Drive, Indianapolis, IN 46202 5111, USA
    Bone 51:795-9. 2012
    ..The lack of association was not affected by race, sex, latitude, or baseline serum 25 (OH) D. Serum 25 (OH) D in the range of 10-46 ng/mL appears to be sufficient for normal bone turnover in healthy black and white pubertal adolescents...
  34. pmc Common genetic determinants of vitamin D insufficiency: a genome-wide association study
    Thomas J Wang
    Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Lancet 376:180-8. 2010
    ..We aimed to identify common genetic variants affecting vitamin D concentrations and risk of insufficiency...
  35. pmc Velocities of bone mineral accrual in black and white American children
    Siu L Hui
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    J Bone Miner Res 25:1527-35. 2010
    ..It is due to black children's higher rate of bone mineral accrual in prepuberty and plausibly in postpuberty. Most of the racial difference in TBMC velocity can be explained by growth in size...
  36. ncbi request reprint Contribution of the LRP5 gene to normal variation in peak BMD in women
    Daniel L Koller
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Bone Miner Res 20:75-80. 2005
    ..Association between SNPs in LRP5 and hip and spine BMD was measured in 1301 premenopausal women. Only a small proportion of the BMD variation was attributable to LRP5 in our sample...
  37. ncbi request reprint Primary hyperparathyroidism and the kidney: biochemical and clinical spectrum
    Munro Peacock
    Department of Medicine, Indiana University School of Medicine, Indianapolis, USA
    J Bone Miner Res 17:N87-94. 2002
    ..Risk factors for nephrocalcinosis are not clearly defined. Parathyroidectomy greatly reduces the incidence of nephrolithiasis but has little effect on nephrocalcinosis...
  38. ncbi request reprint Bone loss at the femoral neck in premenopausal white women: effects of weight change and sex-hormone levels
    Siu L Hui
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Clin Endocrinol Metab 87:1539-43. 2002
    ..In summary, femoral neck BMD decreases in premenopausal women, particularly those with lower levels of estrogens resulting from slowing ovarian function despite regular menses. This decrease can be offset by more rapid weight gain...
  39. pmc Meta-analysis of genome-wide studies identifies WNT16 and ESR1 SNPs associated with bone mineral density in premenopausal women
    Daniel L Koller
    Indiana University School of Medicine, Indianapolis, IN, USA
    J Bone Miner Res 28:547-58. 2013
    ..These data support the hypothesis that variants in these genes of known skeletal function also affect BMD during the premenopausal period...
  40. pmc Serum markers of bone turnover are increased at six and 18 months after Roux-en-Y bariatric surgery: correlation with the reduction in leptin
    Carolina Bruno
    Indiana University School of Medicine, 541 North Clinical Drive, Clinical Building 455, Indianapolis, Indiana 46202 5111
    J Clin Endocrinol Metab 95:159-66. 2010
    ..The aim of the study was to examine serum markers of bone turnover at 6 and 18 months after Roux-en-Y gastric bypass surgery...
  41. pmc Iron deficiency drives an autosomal dominant hypophosphatemic rickets (ADHR) phenotype in fibroblast growth factor-23 (Fgf23) knock-in mice
    Emily G Farrow
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Proc Natl Acad Sci U S A 108:E1146-55. 2011
    ....
  42. ncbi request reprint Summary statement from a workshop on asymptomatic primary hyperparathyroidism: a perspective for the 21st century
    John P Bilezikian
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Bone Miner Res 17:N2-11. 2002
  43. ncbi request reprint Linkage of structure at the proximal femur to chromosomes 3, 7, 8, and 19
    D L Koller
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Bone Miner Res 18:1057-65. 2003
    ..0); and on chromosome 8, to femoral head width (LOD = 6.0). The current findings emphasize the importance of increasing sample size to replicate linkage findings and identify new regions of linkage...
  44. pmc Association studies of ALOX5 and bone mineral density in healthy adults
    T Foroud
    Indiana University School of Medicine, Health Information and Translational Sciences Building, Indianapolis, IN 46202 3002, USA
    Osteoporos Int 19:637-43. 2008
    ..We tested this hypothesis in a sample of healthy men and women and did not find consistent evidence for an association between variation in this gene and either lumbar spine or femoral neck BMD...
  45. ncbi request reprint Intravenous pamidronate treatment of children under 36 months of age with osteogenesis imperfecta
    L A Dimeglio
    Department of Pediatrics, Section of Pediatric Endocrinology and Diabetology, Indiana University School of Medicine, Indianapolis, IN, USA
    Bone 35:1038-45. 2004
    ..To examine this, we instituted a prospective clinical trial of intravenous bisphosphonate to study safety, feasibility, and efficacy of this therapy...
  46. ncbi request reprint A comparison of oral and intravenous bisphosphonate therapy for children with osteogenesis imperfecta
    L A Dimeglio
    Department of Pediatrics, Section of Pediatric Endocrinology and Diabetology, Indiana University School of Medicine, Indianapolis, IN, USA
    J Pediatr Endocrinol Metab 18:43-53. 2005
    ..All children had a decrease in biochemical markers of bone turnover. Linear growth showed a moderate increase above that for age. There was a non-significant decrease in fracture incidence in both groups...
  47. ncbi request reprint Neonatal Iron Deficiency Causes Abnormal Phosphate Metabolism by Elevating FGF23 in Normal and ADHR Mice
    Erica L Clinkenbeard
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA
    J Bone Miner Res 29:361-9. 2014
    ..Therefore, disturbed iron and oxygen metabolism in neonatal life may have important effects on skeletal function and structure through FGF23 activity on phosphate regulation. © 2014 American Society for Bone and Mineral Research. ..
  48. ncbi request reprint Two-year clinical trial of oral alendronate versus intravenous pamidronate in children with osteogenesis imperfecta
    Linda A DiMeglio
    Department of Pediatrics, Section of Pediatric Endocrinology and Diabetology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    J Bone Miner Res 21:132-40. 2006
    ..Children with mild OI had greater responses than severe OI in BMD and growth...
  49. doi request reprint Thoracic phosphaturic mesenchymal tumors causing oncogenic osteomalacia
    Peter J Puthenveetil
    Department of Neurological Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Clin Neurosci 20:1057-61. 2013
    ....
  50. ncbi request reprint Polymorphisms in the bone morphogenetic protein 2 (BMP2) gene do not affect bone mineral density in white men or women
    S Ichikawa
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Osteoporos Int 17:587-92. 2006
    ..Recently, bone morphogenetic protein 2 (BMP2) was reported as a susceptibility gene for osteoporotic fractures and low BMD in Icelandic and Danish populations...
  51. ncbi request reprint Genome screen for QTLs contributing to normal variation in bone mineral density and osteoporosis
    D L Koller
    Indiana University School of Medicine, Indianapolis 46202, USA
    J Clin Endocrinol Metab 85:3116-20. 2000
    ..Our study is the largest genome screen to date for genes underlying variations in peak BMD and represents an important step toward identifying genes contributing to osteoporosis in the general population...
  52. ncbi request reprint Sensitivity of fibroblast growth factor 23 measurements in tumor-induced osteomalacia
    Erik A Imel
    Indiana University School of Medicine, 541 North Clinical Drive, Clinical Building 459, Indianapolis, Indianapolis 46202, USA
    J Clin Endocrinol Metab 91:2055-61. 2006
    ..Fibroblast growth factor 23 (FGF23) is a phosphaturic protein overexpressed in tumors that cause TIO and is, at least partly, responsible for the manifestations of TIO...
  53. ncbi request reprint Genome screen for quantitative trait loci underlying normal variation in femoral structure
    D L Koller
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis 46202, USA
    J Bone Miner Res 16:985-91. 2001
    ..8). This study is the first genome screen for loci underlying variation in femoral structure and represents an important step toward identifying genes contributing to the risk of osteoporotic hip fracture in the general population...
  54. ncbi request reprint Variability in skeletal mass, structure, and biomechanical properties among inbred strains of rats
    C H Turner
    Department of Orthopedic Surgery, Indiana University School of Medicine, Indianapolis, USA
    J Bone Miner Res 16:1532-9. 2001
    ..The results strongly suggest that selected crosses of inbred strains of rats will provide useful models for studying genetic influences on bone strength and structure...
  55. ncbi request reprint Differences in muscle endurance and recovery between fallers and nonfallers, and between young and older women
    K I Schwendner
    School of Medicine, Indiana University, Indianapolis, USA
    J Gerontol A Biol Sci Med Sci 52:M155-60. 1997
    ..Significant morbidity and mortality are associated with falls in older adults. We tested the hypothesis that older women with a history of falls demonstrate decreased muscle endurance and longer recovery times following fatiguing exercise...
  56. ncbi request reprint Racial differences in skeletal calcium retention in adolescent girls with varied controlled calcium intakes
    Michelle Braun
    Department of Foods and Nutrition, Purdue University, West Lafayette, IN 47907, USA
    Am J Clin Nutr 85:1657-63. 2007
    ..Higher bone mass in blacks than in whites has been related to greater calcium utilization efficiency. Dietary calcium requirements for maximal skeletal calcium accretion during puberty may differ between the races...
  57. ncbi request reprint Dairy intakes affect bone density in the elderly
    Linda D McCabe
    Purdue University, West Lafayette, IN, USA
    Am J Clin Nutr 80:1066-74. 2004
    ..Race and sex differences in the effect of diet on bone mineral density (BMD) at the hip in the elderly are unknown...
  58. ncbi request reprint Denosumab in postmenopausal women with low bone mineral density
    Michael R McClung
    Providence Portland Medical Center, Portland, Oreg, USA
    N Engl J Med 354:821-31. 2006
    ..The fully human monoclonal antibody denosumab (formerly known as AMG 162) binds RANKL with high affinity and specificity and inhibits RANKL action...
  59. ncbi request reprint Dietary calcium intake protects women consuming oral contraceptives from spine and hip bone loss
    Dorothy Teegarden
    Interdepartmental Nutrition Program, 700 West State Street, Stone Hall 1264, Purdue University, West Lafayette, Indiana 47907, USA
    J Clin Endocrinol Metab 90:5127-33. 2005
    ..It is estimated that 80% of all women have used oral contraceptives (OCP), but OCP use may prevent attainment of maximal peak bone mass in young women and thus increase the risk of osteoporosis later in life...
  60. ncbi request reprint Meta-analysis of genome-wide scans provides evidence for sex- and site-specific regulation of bone mass
    John P A Ioannidis
    Department of Hygiene and Epidemology, University of Ioannina School of Medicine, Ioannina, Greece
    J Bone Miner Res 22:173-83. 2007
    ..Evidence was gained to suggest that several chromosomal loci regulate BMD in a site-specific and sex-specific manner...
  61. ncbi request reprint The effect of soy protein and soy isoflavones on calcium metabolism in postmenopausal women: a randomized crossover study
    Lisa A Spence
    Department of Foods and Nutrition, Purdue University, West Lafayette, IN, USA
    Am J Clin Nutr 81:916-22. 2005
    ..Evidence suggests that soy isoflavones act as estrogen agonists and have beneficial skeletal effects, but the effects on calcium metabolism in humans are not known...
  62. ncbi request reprint Racial differences in calcium retention in response to dietary salt in adolescent girls
    Karin Wigertz
    Departments of Foods and Nutrition and of Statistics, Purdue University, West Lafayette, IN, USA
    Am J Clin Nutr 81:845-50. 2005
    ..The effect of dietary sodium on calcium retention and the influence of race have not been studied in adolescence, the life stage during which peak bone mass is accrued...
  63. ncbi request reprint Fat oxidation and its relation to serum parathyroid hormone in young women enrolled in a 1-y dairy calcium intervention
    Carolyn W Gunther
    Department of Foods and Nutrition, Purdue University, West Lafayette, IN 47907 1264, USA
    Am J Clin Nutr 82:1228-34. 2005
    ..Increased dietary calcium is associated with changes in body composition. One proposed mechanism is that dietary calcium increases fat oxidation, potentially via regulation of serum parathyroid hormone (PTH) concentrations...
  64. ncbi request reprint Dairy products do not lead to alterations in body weight or fat mass in young women in a 1-y intervention
    Carolyn W Gunther
    Departments of Foods and Nutrition, Purdue University, West Lafayette, IN, USA
    Am J Clin Nutr 81:751-6. 2005
    ..Previous results suggested that increased intake of dairy calcium is associated with reduced weight and fat mass...
  65. ncbi request reprint Calcium retention in adolescent boys on a range of controlled calcium intakes
    Michelle Braun
    Purdue University, West Lafayette, IN, USA
    Am J Clin Nutr 84:414-8. 2006
    ..On average, boys develop larger skeletons than do girls, yet it is unknown whether the additional skeletal accretion in boys requires additional dietary calcium intake...
  66. ncbi request reprint Effect of 1-year dairy product intervention on fat mass in young women: 6-month follow-up
    Marianne S Eagan
    Department of Foods and Nutrition, Purdue University, 1264 Stone Hall, 700 West State Street, West Lafayette, IN 47907, USA
    Obesity (Silver Spring) 14:2242-8. 2006
    ..The objective of this study was to determine the impact of the 1-year dairy intervention 6 months after completion of the intervention...
  67. ncbi request reprint Sodium retention in black and white female adolescents in response to salt intake
    Cristina Palacios
    Department of Foods and Nutrition, Purdue University, West Lafayette, Indiana 47907, USA
    J Clin Endocrinol Metab 89:1858-63. 2004
    ..In summary, black girls showed greater Na(+) retention compared with white girls. The difference in Na(+) handling may contribute to underlying racial differences in susceptibility to hypertension...