Research Topics
| A OraziSummaryAffiliation: Indiana University Country: USA Publications
| Collaborators
|
Detail Information
Publications
Histopathology in the diagnosis and classification of acute myeloid leukemia, myelodysplastic syndromes, and myelodysplastic/myeloproliferative diseasesAttilio Orazi
Indiana University School of Medicine, Division of Hematopathology, Indianapolis, IN 4622 5200, USA
Pathobiology 74:97-114. 2007..Finally, the important group of the myelodysplastic/myeloproliferative disorders can only be accurately categorized by a careful multiparametric approach in which the bone marrow biopsy exerts a pivotal role...- Acute panmyelosis with myelofibrosis: an entity distinct from acute megakaryoblastic leukemiaAttilio Orazi
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202 5200, USA
Mod Pathol 18:603-14. 2005..01 with CD42b). Our results confirm that histology supplemented by immunohistochemistry permits the distinction of these conditions in routinely processed bone marrow biopsies... - The myelodysplastic/myeloproliferative neoplasms: myeloproliferative diseases with dysplastic featuresA Orazi
Department of Pathology and Laboratory Medicine, Clarian Pathology Laboratory, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Leukemia 22:1308-19. 2008..The current 'spotlight' review provides practical guidelines, which should allow for a reproducible classification of these uncommon neoplasms when encountered in clinical practice... - Chronic myelomonocytic leukemia: The role of bone marrow biopsy immunohistologyAttilio Orazi
Clarian Pathology Laboratory, Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202 5200, USA
Mod Pathol 19:1536-45. 2006..Although CD42b immunostaining facilitated the detection of dwarf megakaryocytes often present in CMML, the distinction between those and the small forms seen in chronic myelogenous leukemia was still problematic... - Ex vivo culture of Fancc-/- stem/progenitor cells predisposes cells to undergo apoptosis, and surviving stem/progenitor cells display cytogenetic abnormalities and an increased risk of malignancyXiaxin Li
Cancer Research Institute, 1044 W Walnut Street, Rm 408, Indianapolis, IN 46202 5254, USA
Blood 105:3465-71. 2005..These studies could have implications for the design of genetic therapies for treatment of Fanconi anemia and potentially other genetic diseases with intrinsic defects in genome stability... - Fanconi anemia type C and p53 cooperate in apoptosis and tumorigenesisBrian Freie
Cancer Research Institute, 1044 W Walnut St, R4 408, Indianapolis, IN 46202, USA
Blood 102:4146-52. 2003..Collectively, these data demonstrate that p53 and Fancc interact functionally to regulate apoptosis and tumorigenesis in Fancc-deficient cells... - Adrenal myelolipomas show nonrandom X-chromosome inactivation in hematopoietic elements and fat: support for a clonal origin of myelolipomasElena Bishop
Department of Pathology and Laboratory Medicine, Division of Hematopathology, 702 Barnhill Drive, Riley 0969, Indianapolis, IN 46202, USA
Am J Surg Pathol 30:838-43. 2006..Myelolipomas are morphologically different from the normal bone marrow. The majority of myelolipomas also have nonrandom X-chromosome inactivation, suggesting a clonal origin for these tumors... - Local delivery of nadroparin via hydrogel-coated angioplasty balloon: effect on platelet deposition and smooth muscle cell proliferation--an experimental studyM S Johnson
Department of Radiology, Indiana University School of Medicine, Indianapolis 46202 5253, USA
J Vasc Interv Radiol 11:115-22. 2000.... - Myeloid progenitor cell proliferation and mobilization effects of BB10010, a genetically engineered variant of human macrophage inflammatory protein-1alpha, in a phase I clinical trial in patients with relapsed/refractory breast cancerH E Broxmeyer
Department of Microbiology Immunology and Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Blood Cells Mol Dis 24:14-30. 1998..The above effects of BB10010 were similar at the four different dosage levels assessed. These results demonstrate in humans the suppressive and mobilizing effects of MIP-1alpha and BB10010 previously noted in vivo in mice... - Evaluation of stroma in human immunodeficiency virus/acquired immunodeficiency syndrome-affected bone marrows and correlation with CD4 countsDennis P O'Malley
Division of Hematopathology, Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Arch Pathol Lab Med 129:1137-40. 2005..Little is known about cellular and extracellular composition of fibrosis in bone marrows in the context of human immunodeficiency virus/acquired immunodeficiency syndrome... - Analysis of loss of heterozygosity and X chromosome inactivation in spleens with myeloproliferative disorders and acute myeloid leukemiaDennis P O'Malley
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Mod Pathol 18:1562-8. 2005..Comparison of spleen and bone marrow specimens by LOH demonstrated additional abnormalities in the spleen compared to the marrow... - Chronic lymphocytic leukemia/small lymphocytic lymphoma with trisomy 12 and focal cyclin d1 expression: a potential diagnostic pitfallDennis P O'Malley
Department of Pathology, Division of Hematopathology, Indiana University School of Medicine, Indianapolis 46202, USA
Arch Pathol Lab Med 129:92-5. 2005..Focal cyclin D1 expression by immunohistochemistry in nodal CLL/SLL is quite unusual and is discussed as a potential diagnostic pitfall... - Thrombotic thrombocytopenic purpura: yesterday, today, tomorrowLeo J McCarthy
Department of Pathology and Laboratory Medicine Transfusion Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Ther Apher Dial 8:80-6. 2004..Without the benefit of randomized controlled trials, its treatment, to a large extent, remains not evidence-based but 'eminence-based', making the same mistakes with increasing confidence over an impressive number of years... - Continuous in vivo infusion of interferon-gamma (IFN-gamma) preferentially reduces myeloid progenitor numbers and enhances engraftment of syngeneic wild-type cells in Fancc-/- miceXiaxin Li
Indiana University School of Medicine, Herman B Wells Center for Pediatric Research, Cancer Research Institute, 1044 W Walnut St, Rm 402, Indianapolis, IN 46202 5254, USA
Blood 104:1204-9. 2004.... - Intraocular inflammatory myofibroblastic tumor with ALK overexpressionDennis P O'Malley
Division of Hematopathology, Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis 46202, USA
Arch Pathol Lab Med 128:e5-7. 2004..The authors propose that multiple copies of the ALK gene may be involved in inflammatory myofibroblastic tumor tumorigenesis, in addition to ALK gene rearrangements... - Retroviral-mediated expression of recombinant Fancc enhances the repopulating ability of Fancc-/- hematopoietic stem cells and decreases the risk of clonal evolutionLaura S Haneline
Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indianapolis, IN, USA
Blood 101:1299-307. 2003..These studies also reveal potential detrimental effects of ex vivo manipulation for untransduced Fancc(-/-) HSCs... - Genetic disruption of both Fancc and Fancg in mice recapitulates the hematopoietic manifestations of Fanconi anemiaAnna C Pulliam-Leath
Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA
Blood 116:2915-20. 2010..Importantly, this model closely recapitulates the phenotypes found in FA patients and may be useful as a preclinical platform to evaluate the molecular pathogenesis of spontaneous bone marrow failure, MDS and AML in FA... - Morphologic and immunohistochemical evaluation of splenic hematopoietic proliferations in neoplastic and benign disordersDennis P O'Malley
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Mod Pathol 18:1550-61. 2005..However, they lacked characteristic immunohistochemical features of neoplastic myeloid disorders such as positivity for CD34 or CD117... - The stromal composition of mast cell aggregates in systemic mastocytosisApril Chiu
Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10065, USA
Mod Pathol 22:857-65. 2009.... - K-Ras is essential for normal fetal liver erythropoiesisWaleed F Khalaf
Indiana University School of Medicine, Herman B Wells Center for Pediatric Research, 1044 W Walnut St R4 470, Indianapolis, IN 46202, USA
Blood 105:3538-41. 2005..Thus, these studies identify K-Ras as a unique Ras isoform that is essential for regulating fetal erythropoiesis in vivo... - Transformation of chronic lymphocytic leukemia/small lymphocytic lymphoma to interdigitating dendritic cell sarcoma: evidence for transdifferentiation of the lymphoma cloneCory R Fraser
Division of Hematopathology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10021, USA
Am J Clin Pathol 132:928-39. 2009..This phenomenon may be triggered by alterations in lineage-determining transcription programs, which result in transdifferentiation, coupled with additional oncogenic stimuli caused by chromosomal imbalances... - Transformation of follicular lymphoma to plasmablastic lymphoma with c-myc gene rearrangementIhsane Ouansafi
Division of Hematopathology, Weill Cornell Medical Center New York Presbyterian Hospital, New York, NY, USA
Am J Clin Pathol 134:972-81. 2010..Our study of this unusual case expands the histologic spectrum of FL transformation and increases our understanding of the pathogenetic mechanisms of transformation of indolent lymphomas to aggressive lymphomas... - Antibodies and immunohistochemical evaluation for the diagnosis of hematological malignancies: an overviewAttilio Orazi
Department of Pathology, Indiana School of Medicine, Indianapolis, IN, USA
Methods Mol Biol 378:91-123. 2007..In addition, an immunohistology-based diagnostic approach to identify specific neoplastic entities is described in some length... - Diagnostic criteria to distinguish hypocellular acute myeloid leukemia from hypocellular myelodysplastic syndromes and aplastic anemia: recommendations for a standardized approachJohn M Bennett
James P Wilmot Cancer Center, University of Rochester Medical Center, Department of Pathology and Laboratory Medicine, Rochester, NY 14642, USA
Haematologica 94:264-8. 2009..Guidelines were recommended based on the workshop results as well as additional studies including selective immunohistochemistry, flow cytometry and cytogenetics... - Functional p85alpha gene is required for normal murine fetal erythropoiesisHannah Huddleston
Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 W Walnut St, R4 470, Indianapolis, IN 46202, USA
Blood 102:142-5. 2003..Taken together, these data establish an important role for p85alpha and class IA PI-3 kinase in regulating the development of both early and late erythroid progenitors in fetal liver... - Diffuse blastoid B-cell lymphoma: a histologically aggressive variant of t(14;18)-negative follicular lymphomaApril Chiu
Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, NY 10065, USA
Mod Pathol 22:1507-17. 2009..The molecular pathogenesis, clinical manifestations, and prognostic significance of these lesions remain to be elucidated... - Therapy-related myeloid neoplasmsMagdalena Czader
Department of Pathology and Laboratory Medicine Clarian Pathology Laboratory, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Am J Clin Pathol 132:410-25. 2009..We also present examples of therapy-related acute myeloid leukemias with recurrent cytogenetic abnormalities. In these cases, the precise classification is clinically important because it is associated with distinct clinical outcome... - Interleukin-11 prevents apoptosis and accelerates recovery of small intestinal mucosa in mice treated with combined chemotherapy and radiationA Orazi
Division of Hematopathology, Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
Lab Invest 75:33-42. 1996..IL-11 may thus have potential clinical applications in limiting the intestinal toxicity that is associated with cytotoxic therapies... - Inflammatory pseudotumor of the spleen in a 6-year-old child: a clinicopathologic studyAshit Sarker
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine and Clarian Health Partners, Indianapolis, IN 46202-5200, USA
Arch Pathol Lab Med 127:e127-30. 2003..Splenic inflammatory pseudotumors, although rare, should be considered in the differential diagnosis of a mass lesion of the spleen in children... - Bone marrow histopathology in myeloproliferative disorders--current diagnostic approachJuergen Thiele
Institute of Pathology, Cologne University, Joseph Stelzmann Strasse 9, D 50924 Cologne, Germany
Semin Hematol 42:184-95. 2005.... - Primary testicular diffuse large B-cell lymphoma belongs to the nongerminal center B-cell-like subgroup: A study of 18 casesMousa A Al-Abbadi
Department of Pathology, Wayne State University, Detroit, MI, USA
Mod Pathol 19:1521-7. 2006..We conclude that most (89%) primary testicular lymphomas of the diffuse large B-cell type belong to the nongerminal center B-cell-like subgroup and have high proliferative activity... - Flow cytometric analysis of normal and reactive spleenAdriana I Colovai
Department of Pathology, Columbia University, New York, NY 10032, USA
Mod Pathol 17:918-27. 2004..These results will facilitate an accurate interpretation of the flow cytometric analysis of human spleen lymphocytes... - Chronic idiopathic myelofibrosis: independent prognostic importance of bone marrow microvascular density evaluated by CD105 (endoglin) immunostainingMaurilio Ponzoni
Department of Pathology, San Raffaele H Scientific Institute, Milan, Italy
Mod Pathol 17:1513-20. 2004..These findings provide a rationale for the investigational use of anti-CD105-targeted drugs in CIMF... - Primary mediastinal germ cell tumor evolving into an extramedullary acute megakaryoblastic leukemia causing cord compressionGovinda R Brahmanday
William Beaumont Hospital, Royal Oak, MI, USA
J Clin Oncol 26:4686-8. 2008 - Loss of heterozygosity identifies genetic changes in chronic myeloid disorders, including myeloproliferative disorders, myelodysplastic syndromes and chronic myelomonocytic leukemiaDennis P O'Malley
US Labs, 2601 Campus Drive, Irvine, CA 92612, USA
Mod Pathol 20:1166-71. 2007..Although different from both, chronic myelomonocytic leukemia appeared more similar to myeloproliferative disorders using these techniques... - Leptomeningeal relapse of multiple myeloma following allogeneic stem cell transplantationDavid G Savage
Hematology Oncology Division, Columbia University College of Physicians and Surgeons, 177 Fort Washington Avenue, New York City, NY 10032, USA
Leuk Res 26:689-92. 2002..The leptomeningeal disease led to death at 38 months. This is the first report of leptomeningeal relapse of myeloma after allografting... - Expression of the IRTA1 receptor identifies intraepithelial and subepithelial marginal zone B cells of the mucosa-associated lymphoid tissue (MALT)Brunangelo Falini
Institute of Hematology, University of Perugia, 06122 Perugia, Italy
Blood 102:3684-92. 2003..Collectively, these results suggest a role of IRTA1 in the immune function of B cells within epithelia... - The importance of angiogenesis markers in the outcome of patients with diffuse large B cell lymphoma: a retrospective study of 97 patientsKristen N Ganjoo
Division of Oncology, Stanford University, Stanford, CA, USA
J Cancer Res Clin Oncol 134:381-7. 2008..This is a single institution retrospective study evaluating the role of angiogenesis markers in the clinical outcome of patients with diffuse large B cell lymphoma (DLBCL)... - Primary testicular and paratesticular lymphoma: a retrospective clinicopathologic study of 34 cases with emphasis on differential diagnosisMousa A Al Abbadi
Department of Pathology, Wayne State University Detroit Medical Center, Detroit, Mich, USA
Arch Pathol Lab Med 131:1040-6. 2007..Recent reports indicate the rate of primary testicular lymphomas is on the rise and misdiagnosis can still occur... - Proposals and rationale for revision of the World Health Organization diagnostic criteria for polycythemia vera, essential thrombocythemia, and primary myelofibrosis: recommendations from an ad hoc international expert panelAyalew Tefferi
Mayo Clinic, Rochester, MN 55905, USA
Blood 110:1092-7. 2007.... - Primary myelofibrosis (PMF), post polycythemia vera myelofibrosis (post-PV MF), post essential thrombocythemia myelofibrosis (post-ET MF), blast phase PMF (PMF-BP): Consensus on terminology by the international working group for myelofibrosis research andRuben A Mesa
Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Leuk Res 31:737-40. 2007.... - Terminal deoxynucleotidyl transferase-positive cells in spleen, appendix and branchial cleft cysts in pediatric patientsAttilio Orazi
Haematologica 91:1139-40. 2006..In spleen, appendix and branchial cleft cysts the range of TdT-positivity was 0-13, 0-96 and 0-6 TdT+ cells/hpf, respectively. In spleens, scattered TdT+ cells were seen most frequently in periarteriolar lymphoid sheath regions... - Rituximab, bevacizumab and CHOP (RA-CHOP) in untreated diffuse large B-cell lymphoma: safety, biomarker and pharmacokinetic analysisKristen N Ganjoo
Department of Medicine Oncology, Stanford University, CA, USA
Leuk Lymphoma 47:998-1005. 2006..In this patient population, treatment with RA-CHOP did not result in any episodes of grade 3 or 4 proteinuria, heart failure or hemorrhage. The RA-CHOP combination was generally well tolerated and safe... - European consensus on grading bone marrow fibrosis and assessment of cellularityJurgen Thiele
Institute for Pathology, University of Cologne, Germany
Haematologica 90:1128-32. 2005..The consensus for measuring myelofibrosis by clear and reproducible guidelines achieved by our group should allow for precise grading during the disease process and after therapy...