A Orazi

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. ncbi request reprint Histopathology in the diagnosis and classification of acute myeloid leukemia, myelodysplastic syndromes, and myelodysplastic/myeloproliferative diseases
    Attilio Orazi
    Indiana University School of Medicine, Division of Hematopathology, Indianapolis, IN 4622 5200, USA
    Pathobiology 74:97-114. 2007
  2. ncbi request reprint Acute panmyelosis with myelofibrosis: an entity distinct from acute megakaryoblastic leukemia
    Attilio Orazi
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202 5200, USA
    Mod Pathol 18:603-14. 2005
  3. doi request reprint The myelodysplastic/myeloproliferative neoplasms: myeloproliferative diseases with dysplastic features
    A Orazi
    Department of Pathology and Laboratory Medicine, Clarian Pathology Laboratory, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Leukemia 22:1308-19. 2008
  4. ncbi request reprint Chronic myelomonocytic leukemia: The role of bone marrow biopsy immunohistology
    Attilio Orazi
    Clarian Pathology Laboratory, Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202 5200, USA
    Mod Pathol 19:1536-45. 2006
  5. pmc Ex vivo culture of Fancc-/- stem/progenitor cells predisposes cells to undergo apoptosis, and surviving stem/progenitor cells display cytogenetic abnormalities and an increased risk of malignancy
    Xiaxin Li
    Cancer Research Institute, 1044 W Walnut Street, Rm 408, Indianapolis, IN 46202 5254, USA
    Blood 105:3465-71. 2005
  6. ncbi request reprint Fanconi anemia type C and p53 cooperate in apoptosis and tumorigenesis
    Brian Freie
    Cancer Research Institute, 1044 W Walnut St, R4 408, Indianapolis, IN 46202, USA
    Blood 102:4146-52. 2003
  7. ncbi request reprint Adrenal myelolipomas show nonrandom X-chromosome inactivation in hematopoietic elements and fat: support for a clonal origin of myelolipomas
    Elena Bishop
    Department of Pathology and Laboratory Medicine, Division of Hematopathology, 702 Barnhill Drive, Riley 0969, Indianapolis, IN 46202, USA
    Am J Surg Pathol 30:838-43. 2006
  8. ncbi request reprint Local delivery of nadroparin via hydrogel-coated angioplasty balloon: effect on platelet deposition and smooth muscle cell proliferation--an experimental study
    M S Johnson
    Department of Radiology, Indiana University School of Medicine, Indianapolis 46202 5253, USA
    J Vasc Interv Radiol 11:115-22. 2000
  9. ncbi request reprint Myeloid progenitor cell proliferation and mobilization effects of BB10010, a genetically engineered variant of human macrophage inflammatory protein-1alpha, in a phase I clinical trial in patients with relapsed/refractory breast cancer
    H E Broxmeyer
    Department of Microbiology Immunology and Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Blood Cells Mol Dis 24:14-30. 1998
  10. ncbi request reprint Evaluation of stroma in human immunodeficiency virus/acquired immunodeficiency syndrome-affected bone marrows and correlation with CD4 counts
    Dennis P O'Malley
    Division of Hematopathology, Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Arch Pathol Lab Med 129:1137-40. 2005

Detail Information

Publications44

  1. ncbi request reprint Histopathology in the diagnosis and classification of acute myeloid leukemia, myelodysplastic syndromes, and myelodysplastic/myeloproliferative diseases
    Attilio Orazi
    Indiana University School of Medicine, Division of Hematopathology, Indianapolis, IN 4622 5200, USA
    Pathobiology 74:97-114. 2007
    ..Finally, the important group of the myelodysplastic/myeloproliferative disorders can only be accurately categorized by a careful multiparametric approach in which the bone marrow biopsy exerts a pivotal role...
  2. ncbi request reprint Acute panmyelosis with myelofibrosis: an entity distinct from acute megakaryoblastic leukemia
    Attilio Orazi
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202 5200, USA
    Mod Pathol 18:603-14. 2005
    ..01 with CD42b). Our results confirm that histology supplemented by immunohistochemistry permits the distinction of these conditions in routinely processed bone marrow biopsies...
  3. doi request reprint The myelodysplastic/myeloproliferative neoplasms: myeloproliferative diseases with dysplastic features
    A Orazi
    Department of Pathology and Laboratory Medicine, Clarian Pathology Laboratory, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Leukemia 22:1308-19. 2008
    ..The current 'spotlight' review provides practical guidelines, which should allow for a reproducible classification of these uncommon neoplasms when encountered in clinical practice...
  4. ncbi request reprint Chronic myelomonocytic leukemia: The role of bone marrow biopsy immunohistology
    Attilio Orazi
    Clarian Pathology Laboratory, Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202 5200, USA
    Mod Pathol 19:1536-45. 2006
    ..Although CD42b immunostaining facilitated the detection of dwarf megakaryocytes often present in CMML, the distinction between those and the small forms seen in chronic myelogenous leukemia was still problematic...
  5. pmc Ex vivo culture of Fancc-/- stem/progenitor cells predisposes cells to undergo apoptosis, and surviving stem/progenitor cells display cytogenetic abnormalities and an increased risk of malignancy
    Xiaxin Li
    Cancer Research Institute, 1044 W Walnut Street, Rm 408, Indianapolis, IN 46202 5254, USA
    Blood 105:3465-71. 2005
    ..These studies could have implications for the design of genetic therapies for treatment of Fanconi anemia and potentially other genetic diseases with intrinsic defects in genome stability...
  6. ncbi request reprint Fanconi anemia type C and p53 cooperate in apoptosis and tumorigenesis
    Brian Freie
    Cancer Research Institute, 1044 W Walnut St, R4 408, Indianapolis, IN 46202, USA
    Blood 102:4146-52. 2003
    ..Collectively, these data demonstrate that p53 and Fancc interact functionally to regulate apoptosis and tumorigenesis in Fancc-deficient cells...
  7. ncbi request reprint Adrenal myelolipomas show nonrandom X-chromosome inactivation in hematopoietic elements and fat: support for a clonal origin of myelolipomas
    Elena Bishop
    Department of Pathology and Laboratory Medicine, Division of Hematopathology, 702 Barnhill Drive, Riley 0969, Indianapolis, IN 46202, USA
    Am J Surg Pathol 30:838-43. 2006
    ..Myelolipomas are morphologically different from the normal bone marrow. The majority of myelolipomas also have nonrandom X-chromosome inactivation, suggesting a clonal origin for these tumors...
  8. ncbi request reprint Local delivery of nadroparin via hydrogel-coated angioplasty balloon: effect on platelet deposition and smooth muscle cell proliferation--an experimental study
    M S Johnson
    Department of Radiology, Indiana University School of Medicine, Indianapolis 46202 5253, USA
    J Vasc Interv Radiol 11:115-22. 2000
    ....
  9. ncbi request reprint Myeloid progenitor cell proliferation and mobilization effects of BB10010, a genetically engineered variant of human macrophage inflammatory protein-1alpha, in a phase I clinical trial in patients with relapsed/refractory breast cancer
    H E Broxmeyer
    Department of Microbiology Immunology and Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Blood Cells Mol Dis 24:14-30. 1998
    ..The above effects of BB10010 were similar at the four different dosage levels assessed. These results demonstrate in humans the suppressive and mobilizing effects of MIP-1alpha and BB10010 previously noted in vivo in mice...
  10. ncbi request reprint Evaluation of stroma in human immunodeficiency virus/acquired immunodeficiency syndrome-affected bone marrows and correlation with CD4 counts
    Dennis P O'Malley
    Division of Hematopathology, Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Arch Pathol Lab Med 129:1137-40. 2005
    ..Little is known about cellular and extracellular composition of fibrosis in bone marrows in the context of human immunodeficiency virus/acquired immunodeficiency syndrome...
  11. ncbi request reprint Analysis of loss of heterozygosity and X chromosome inactivation in spleens with myeloproliferative disorders and acute myeloid leukemia
    Dennis P O'Malley
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Mod Pathol 18:1562-8. 2005
    ..Comparison of spleen and bone marrow specimens by LOH demonstrated additional abnormalities in the spleen compared to the marrow...
  12. ncbi request reprint Chronic lymphocytic leukemia/small lymphocytic lymphoma with trisomy 12 and focal cyclin d1 expression: a potential diagnostic pitfall
    Dennis P O'Malley
    Department of Pathology, Division of Hematopathology, Indiana University School of Medicine, Indianapolis 46202, USA
    Arch Pathol Lab Med 129:92-5. 2005
    ..Focal cyclin D1 expression by immunohistochemistry in nodal CLL/SLL is quite unusual and is discussed as a potential diagnostic pitfall...
  13. ncbi request reprint Thrombotic thrombocytopenic purpura: yesterday, today, tomorrow
    Leo J McCarthy
    Department of Pathology and Laboratory Medicine Transfusion Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Ther Apher Dial 8:80-6. 2004
    ..Without the benefit of randomized controlled trials, its treatment, to a large extent, remains not evidence-based but 'eminence-based', making the same mistakes with increasing confidence over an impressive number of years...
  14. ncbi request reprint Continuous in vivo infusion of interferon-gamma (IFN-gamma) preferentially reduces myeloid progenitor numbers and enhances engraftment of syngeneic wild-type cells in Fancc-/- mice
    Xiaxin Li
    Indiana University School of Medicine, Herman B Wells Center for Pediatric Research, Cancer Research Institute, 1044 W Walnut St, Rm 402, Indianapolis, IN 46202 5254, USA
    Blood 104:1204-9. 2004
    ....
  15. ncbi request reprint Intraocular inflammatory myofibroblastic tumor with ALK overexpression
    Dennis P O'Malley
    Division of Hematopathology, Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis 46202, USA
    Arch Pathol Lab Med 128:e5-7. 2004
    ..The authors propose that multiple copies of the ALK gene may be involved in inflammatory myofibroblastic tumor tumorigenesis, in addition to ALK gene rearrangements...
  16. ncbi request reprint Retroviral-mediated expression of recombinant Fancc enhances the repopulating ability of Fancc-/- hematopoietic stem cells and decreases the risk of clonal evolution
    Laura S Haneline
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indianapolis, IN, USA
    Blood 101:1299-307. 2003
    ..These studies also reveal potential detrimental effects of ex vivo manipulation for untransduced Fancc(-/-) HSCs...
  17. pmc Genetic disruption of both Fancc and Fancg in mice recapitulates the hematopoietic manifestations of Fanconi anemia
    Anna C Pulliam-Leath
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA
    Blood 116:2915-20. 2010
    ..Importantly, this model closely recapitulates the phenotypes found in FA patients and may be useful as a preclinical platform to evaluate the molecular pathogenesis of spontaneous bone marrow failure, MDS and AML in FA...
  18. ncbi request reprint Morphologic and immunohistochemical evaluation of splenic hematopoietic proliferations in neoplastic and benign disorders
    Dennis P O'Malley
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Mod Pathol 18:1550-61. 2005
    ..However, they lacked characteristic immunohistochemical features of neoplastic myeloid disorders such as positivity for CD34 or CD117...
  19. doi request reprint The stromal composition of mast cell aggregates in systemic mastocytosis
    April Chiu
    Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10065, USA
    Mod Pathol 22:857-65. 2009
    ....
  20. ncbi request reprint K-Ras is essential for normal fetal liver erythropoiesis
    Waleed F Khalaf
    Indiana University School of Medicine, Herman B Wells Center for Pediatric Research, 1044 W Walnut St R4 470, Indianapolis, IN 46202, USA
    Blood 105:3538-41. 2005
    ..Thus, these studies identify K-Ras as a unique Ras isoform that is essential for regulating fetal erythropoiesis in vivo...
  21. doi request reprint Transformation of chronic lymphocytic leukemia/small lymphocytic lymphoma to interdigitating dendritic cell sarcoma: evidence for transdifferentiation of the lymphoma clone
    Cory R Fraser
    Division of Hematopathology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10021, USA
    Am J Clin Pathol 132:928-39. 2009
    ..This phenomenon may be triggered by alterations in lineage-determining transcription programs, which result in transdifferentiation, coupled with additional oncogenic stimuli caused by chromosomal imbalances...
  22. doi request reprint Transformation of follicular lymphoma to plasmablastic lymphoma with c-myc gene rearrangement
    Ihsane Ouansafi
    Division of Hematopathology, Weill Cornell Medical Center New York Presbyterian Hospital, New York, NY, USA
    Am J Clin Pathol 134:972-81. 2010
    ..Our study of this unusual case expands the histologic spectrum of FL transformation and increases our understanding of the pathogenetic mechanisms of transformation of indolent lymphomas to aggressive lymphomas...
  23. ncbi request reprint Antibodies and immunohistochemical evaluation for the diagnosis of hematological malignancies: an overview
    Attilio Orazi
    Department of Pathology, Indiana School of Medicine, Indianapolis, IN, USA
    Methods Mol Biol 378:91-123. 2007
    ..In addition, an immunohistology-based diagnostic approach to identify specific neoplastic entities is described in some length...
  24. pmc Diagnostic criteria to distinguish hypocellular acute myeloid leukemia from hypocellular myelodysplastic syndromes and aplastic anemia: recommendations for a standardized approach
    John M Bennett
    James P Wilmot Cancer Center, University of Rochester Medical Center, Department of Pathology and Laboratory Medicine, Rochester, NY 14642, USA
    Haematologica 94:264-8. 2009
    ..Guidelines were recommended based on the workshop results as well as additional studies including selective immunohistochemistry, flow cytometry and cytogenetics...
  25. ncbi request reprint Functional p85alpha gene is required for normal murine fetal erythropoiesis
    Hannah Huddleston
    Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 W Walnut St, R4 470, Indianapolis, IN 46202, USA
    Blood 102:142-5. 2003
    ..Taken together, these data establish an important role for p85alpha and class IA PI-3 kinase in regulating the development of both early and late erythroid progenitors in fetal liver...
  26. doi request reprint Diffuse blastoid B-cell lymphoma: a histologically aggressive variant of t(14;18)-negative follicular lymphoma
    April Chiu
    Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, NY 10065, USA
    Mod Pathol 22:1507-17. 2009
    ..The molecular pathogenesis, clinical manifestations, and prognostic significance of these lesions remain to be elucidated...
  27. doi request reprint Therapy-related myeloid neoplasms
    Magdalena Czader
    Department of Pathology and Laboratory Medicine Clarian Pathology Laboratory, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Am J Clin Pathol 132:410-25. 2009
    ..We also present examples of therapy-related acute myeloid leukemias with recurrent cytogenetic abnormalities. In these cases, the precise classification is clinically important because it is associated with distinct clinical outcome...
  28. ncbi request reprint Interleukin-11 prevents apoptosis and accelerates recovery of small intestinal mucosa in mice treated with combined chemotherapy and radiation
    A Orazi
    Division of Hematopathology, Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Lab Invest 75:33-42. 1996
    ..IL-11 may thus have potential clinical applications in limiting the intestinal toxicity that is associated with cytotoxic therapies...
  29. ncbi request reprint Inflammatory pseudotumor of the spleen in a 6-year-old child: a clinicopathologic study
    Ashit Sarker
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine and Clarian Health Partners, Indianapolis, IN 46202 5200, USA
    Arch Pathol Lab Med 127:e127-30. 2003
    ..Splenic inflammatory pseudotumors, although rare, should be considered in the differential diagnosis of a mass lesion of the spleen in children...
  30. ncbi request reprint Bone marrow histopathology in myeloproliferative disorders--current diagnostic approach
    Juergen Thiele
    Institute of Pathology, Cologne University, Joseph Stelzmann Strasse 9, D 50924 Cologne, Germany
    Semin Hematol 42:184-95. 2005
    ....
  31. ncbi request reprint Primary testicular diffuse large B-cell lymphoma belongs to the nongerminal center B-cell-like subgroup: A study of 18 cases
    Mousa A Al-Abbadi
    Department of Pathology, Wayne State University, Detroit, MI, USA
    Mod Pathol 19:1521-7. 2006
    ..We conclude that most (89%) primary testicular lymphomas of the diffuse large B-cell type belong to the nongerminal center B-cell-like subgroup and have high proliferative activity...
  32. ncbi request reprint Flow cytometric analysis of normal and reactive spleen
    Adriana I Colovai
    Department of Pathology, Columbia University, New York, NY 10032, USA
    Mod Pathol 17:918-27. 2004
    ..These results will facilitate an accurate interpretation of the flow cytometric analysis of human spleen lymphocytes...
  33. ncbi request reprint Chronic idiopathic myelofibrosis: independent prognostic importance of bone marrow microvascular density evaluated by CD105 (endoglin) immunostaining
    Maurilio Ponzoni
    Department of Pathology, San Raffaele H Scientific Institute, Milan, Italy
    Mod Pathol 17:1513-20. 2004
    ..These findings provide a rationale for the investigational use of anti-CD105-targeted drugs in CIMF...
  34. doi request reprint Primary mediastinal germ cell tumor evolving into an extramedullary acute megakaryoblastic leukemia causing cord compression
    Govinda R Brahmanday
    William Beaumont Hospital, Royal Oak, MI, USA
    J Clin Oncol 26:4686-8. 2008
  35. ncbi request reprint Loss of heterozygosity identifies genetic changes in chronic myeloid disorders, including myeloproliferative disorders, myelodysplastic syndromes and chronic myelomonocytic leukemia
    Dennis P O'Malley
    US Labs, 2601 Campus Drive, Irvine, CA 92612, USA
    Mod Pathol 20:1166-71. 2007
    ..Although different from both, chronic myelomonocytic leukemia appeared more similar to myeloproliferative disorders using these techniques...
  36. ncbi request reprint Leptomeningeal relapse of multiple myeloma following allogeneic stem cell transplantation
    David G Savage
    Hematology Oncology Division, Columbia University College of Physicians and Surgeons, 177 Fort Washington Avenue, New York City, NY 10032, USA
    Leuk Res 26:689-92. 2002
    ..The leptomeningeal disease led to death at 38 months. This is the first report of leptomeningeal relapse of myeloma after allografting...
  37. ncbi request reprint Expression of the IRTA1 receptor identifies intraepithelial and subepithelial marginal zone B cells of the mucosa-associated lymphoid tissue (MALT)
    Brunangelo Falini
    Institute of Hematology, University of Perugia, 06122 Perugia, Italy
    Blood 102:3684-92. 2003
    ..Collectively, these results suggest a role of IRTA1 in the immune function of B cells within epithelia...
  38. ncbi request reprint The importance of angiogenesis markers in the outcome of patients with diffuse large B cell lymphoma: a retrospective study of 97 patients
    Kristen N Ganjoo
    Division of Oncology, Stanford University, Stanford, CA, USA
    J Cancer Res Clin Oncol 134:381-7. 2008
    ..This is a single institution retrospective study evaluating the role of angiogenesis markers in the clinical outcome of patients with diffuse large B cell lymphoma (DLBCL)...
  39. ncbi request reprint Primary testicular and paratesticular lymphoma: a retrospective clinicopathologic study of 34 cases with emphasis on differential diagnosis
    Mousa A Al-Abbadi
    Department of Pathology, Wayne State University Detroit Medical Center, Detroit, Mich, USA
    Arch Pathol Lab Med 131:1040-6. 2007
    ..Recent reports indicate the rate of primary testicular lymphomas is on the rise and misdiagnosis can still occur...
  40. ncbi request reprint Proposals and rationale for revision of the World Health Organization diagnostic criteria for polycythemia vera, essential thrombocythemia, and primary myelofibrosis: recommendations from an ad hoc international expert panel
    Ayalew Tefferi
    Mayo Clinic, Rochester, MN 55905, USA
    Blood 110:1092-7. 2007
    ....
  41. ncbi request reprint Primary myelofibrosis (PMF), post polycythemia vera myelofibrosis (post-PV MF), post essential thrombocythemia myelofibrosis (post-ET MF), blast phase PMF (PMF-BP): Consensus on terminology by the international working group for myelofibrosis research and
    Ruben A Mesa
    Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Leuk Res 31:737-40. 2007
    ....
  42. ncbi request reprint Terminal deoxynucleotidyl transferase-positive cells in spleen, appendix and branchial cleft cysts in pediatric patients
    Dennis P O'Malley
    Haematologica 91:1139-40. 2006
    ..In spleen, appendix and branchial cleft cysts the range of TdT-positivity was 0-13, 0-96 and 0-6 TdT+ cells/hpf, respectively. In spleens, scattered TdT+ cells were seen most frequently in periarteriolar lymphoid sheath regions...
  43. ncbi request reprint Rituximab, bevacizumab and CHOP (RA-CHOP) in untreated diffuse large B-cell lymphoma: safety, biomarker and pharmacokinetic analysis
    Kristen N Ganjoo
    Department of Medicine Oncology, Stanford University, CA, USA
    Leuk Lymphoma 47:998-1005. 2006
    ..In this patient population, treatment with RA-CHOP did not result in any episodes of grade 3 or 4 proteinuria, heart failure or hemorrhage. The RA-CHOP combination was generally well tolerated and safe...
  44. ncbi request reprint European consensus on grading bone marrow fibrosis and assessment of cellularity
    Jurgen Thiele
    Institute for Pathology, University of Cologne, Germany
    Haematologica 90:1128-32. 2005
    ..The consensus for measuring myelofibrosis by clear and reproducible guidelines achieved by our group should allow for precise grading during the disease process and after therapy...