J I Nurnberger

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. pmc Multi-species data integration and gene ranking enrich significant results in an alcoholism genome-wide association study
    Zhongming Zhao
    Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    BMC Genomics 13:S16. 2012
  2. ncbi request reprint Melatonin suppression by light in euthymic bipolar and unipolar patients
    J I Nurnberger
    Department of Psychiatry, Indiana University School of Medicine, Ind 46202 4887, USA
    Arch Gen Psychiatry 57:572-9. 2000
  3. ncbi request reprint A family study of alcohol dependence: coaggregation of multiple disorders in relatives of alcohol-dependent probands
    John I Nurnberger
    Institute of Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, Indianapolis 46202 4887, USA
    Arch Gen Psychiatry 61:1246-56. 2004
  4. ncbi request reprint Molecular psychiatry meeting, February 2004, Park City, Utah
    John I Nurnberger
    Department of Psychiatry, Indiana University Medical Center, 791 Union Drive, Indianapolis, IN 46202 4887, USA
    Psychiatr Genet 15:79-80. 2005
  5. ncbi request reprint Meeting report for Molecular Psychiatry, 2005
    John Nurnberger
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, 46202, USA
    Psychiatr Genet 16:89-90. 2006
  6. doi request reprint A simulated genetic structure for bipolar illness
    John I Nurnberger
    Institute of Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, 791 Union Drive, IUMC IPR, Indianapolis, IN 46202 4887, USA
    Am J Med Genet B Neuropsychiatr Genet 147:952-6. 2008
  7. doi request reprint A high-risk study of bipolar disorder. Childhood clinical phenotypes as precursors of major mood disorders
    John I Nurnberger
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, 46202 4887, USA
    Arch Gen Psychiatry 68:1012-20. 2011
  8. ncbi request reprint Evidence for a locus on chromosome 1 that influences vulnerability to alcoholism and affective disorder
    J I Nurnberger
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis 46202 4887, USA
    Am J Psychiatry 158:718-24. 2001
  9. ncbi request reprint Genetics of bipolar affective disorder
    J I Nurnberger
    Department of Psychiatry, The Institute of Psychiatric Research, 791 Union Drive, Indiana University Medical Center, Indianapolis, IN 46202, USA
    Curr Psychiatry Rep 2:147-57. 2000
  10. ncbi request reprint Chromosome 6 workshop report
    J I Nurnberger
    Indiana University School of Medicine, Indianapolis, USA
    Am J Med Genet 88:233-8. 1999

Research Grants

  1. Adolescents at High Risk for Familial Bipolar Disorder
    John Nurnberger; Fiscal Year: 2007
  2. A COLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDER
    John Nurnberger; Fiscal Year: 2007
  3. COLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDER
    John Nurnberger; Fiscal Year: 2001
  4. Adolescents at High Risk for Familial Bipolar Disorder
    John Nurnberger; Fiscal Year: 2009

Collaborators

Detail Information

Publications88

  1. pmc Multi-species data integration and gene ranking enrich significant results in an alcoholism genome-wide association study
    Zhongming Zhao
    Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    BMC Genomics 13:S16. 2012
    ..Integration of these heterogeneous data can be used to produce a ranked target gene list for additional investigation...
  2. ncbi request reprint Melatonin suppression by light in euthymic bipolar and unipolar patients
    J I Nurnberger
    Department of Psychiatry, Indiana University School of Medicine, Ind 46202 4887, USA
    Arch Gen Psychiatry 57:572-9. 2000
    ..Nighttime levels of corticotropin and cortisol were also examined as potential trait vulnerability markers...
  3. ncbi request reprint A family study of alcohol dependence: coaggregation of multiple disorders in relatives of alcohol-dependent probands
    John I Nurnberger
    Institute of Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, Indianapolis 46202 4887, USA
    Arch Gen Psychiatry 61:1246-56. 2004
    ..We also assessed the aggregation of other psychiatric disorders in the same sample to identify areas of possible shared genetic vulnerability...
  4. ncbi request reprint Molecular psychiatry meeting, February 2004, Park City, Utah
    John I Nurnberger
    Department of Psychiatry, Indiana University Medical Center, 791 Union Drive, Indianapolis, IN 46202 4887, USA
    Psychiatr Genet 15:79-80. 2005
    ..The 11th Annual Molecular Psychiatry Meeting was held from 8 to 10 February 2004, at the Treasure Mountain Inn in Park City, Utah. The meeting was hosted by Bill Byerley, University of California, Irvine...
  5. ncbi request reprint Meeting report for Molecular Psychiatry, 2005
    John Nurnberger
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, 46202, USA
    Psychiatr Genet 16:89-90. 2006
    ..The 2005 Molecular Psychiatry Meeting was held from 6 to 8 February 2005 at the Treasure Mountain Inn in Park City, Utah...
  6. doi request reprint A simulated genetic structure for bipolar illness
    John I Nurnberger
    Institute of Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, 791 Union Drive, IUMC IPR, Indianapolis, IN 46202 4887, USA
    Am J Med Genet B Neuropsychiatr Genet 147:952-6. 2008
    ..As the neurobiology of replicated candidate genes is considered, models of potentially relevant biological pathways may be constructed...
  7. doi request reprint A high-risk study of bipolar disorder. Childhood clinical phenotypes as precursors of major mood disorders
    John I Nurnberger
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, 46202 4887, USA
    Arch Gen Psychiatry 68:1012-20. 2011
    ..The childhood precursors of adult bipolar disorder (BP) are still a matter of controversy...
  8. ncbi request reprint Evidence for a locus on chromosome 1 that influences vulnerability to alcoholism and affective disorder
    J I Nurnberger
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis 46202 4887, USA
    Am J Psychiatry 158:718-24. 2001
    ..Data from the collaborative study were used to test three phenotypes (comorbid alcoholism and depression, alcoholism or depression, and depression) for genetic linkage...
  9. ncbi request reprint Genetics of bipolar affective disorder
    J I Nurnberger
    Department of Psychiatry, The Institute of Psychiatric Research, 791 Union Drive, Indiana University Medical Center, Indianapolis, IN 46202, USA
    Curr Psychiatry Rep 2:147-57. 2000
    ..A convincing demonstration for a susceptibility gene will probably require a mixture of case- control studies, family-based association methods, and pathophysiologic studies...
  10. ncbi request reprint Chromosome 6 workshop report
    J I Nurnberger
    Indiana University School of Medicine, Indianapolis, USA
    Am J Med Genet 88:233-8. 1999
    ..Interest continues to center on 6p 24-22 for schizophrenia. Another area of possible linkage to both schizophrenia and bipolar disorder exists at 6q 21-22. Neither of these areas maybe considered confirmed at this time...
  11. doi request reprint Phenomic, convergent functional genomic, and biomarker studies in a stress-reactive genetic animal model of bipolar disorder and co-morbid alcoholism
    H Le-Niculescu
    Laboratory of Neurophenomics, Indiana University School of Medicine, Indianapolis, Indiana
    Am J Med Genet B Neuropsychiatr Genet 147:134-66. 2008
    ..CFG analysis of the gene expression changes identified a series of novel candidate genes and blood biomarkers for bipolar disorder, alcoholism, and stress reactivity...
  12. ncbi request reprint Familial transmission of substance dependence: alcohol, marijuana, cocaine, and habitual smoking: a report from the Collaborative Study on the Genetics of Alcoholism
    L J Bierut
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Gen Psychiatry 55:982-8. 1998
    ..Alcoholism and substance dependence frequently co-occur. Accordingly, we evaluated the familial transmission of alcohol, marijuana, and cocaine dependence and habitual smoking in the Collaborative Study on the Genetics of Alcoholism...
  13. doi request reprint Identifying blood biomarkers for mood disorders using convergent functional genomics
    H Le-Niculescu
    Laboratory of Neurophenomics, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202 4887, USA
    Mol Psychiatry 14:156-74. 2009
    ..Our studies suggest that blood biomarkers may offer an unexpectedly informative window into brain functioning and disease state...
  14. ncbi request reprint Quantitative trait loci (QTL) for circadian rhythms of locomotor activity in mice
    J R Hofstetter
    Department of Veterans Affairs, Richard L Roudebush Medical Center, Indianapolis, Indiana, USA
    Behav Genet 25:545-56. 1995
    ..05) with that reported for the period of wheel running activity in seven C x B RI strains (Schwartz, W.J., and Zimmerman, P., J. Neurosci. 10:3685 1990)...
  15. doi request reprint Coming to grips with complex disorders: genetic risk prediction in bipolar disorder using panels of genes identified through convergent functional genomics
    S D Patel
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Am J Med Genet B Neuropsychiatr Genet 153:850-77. 2010
    ..Lastly, we describe a prototype of how such testing could be used to categorize disease risk in individuals and aid personalized medicine approaches, in psychiatry and beyond...
  16. ncbi request reprint Genome screen for platelet monoamine oxidase (MAO) activity
    N L Saccone
    Department of Psychiatry, Washington University, St Louis, Missouri, USA
    Am J Med Genet 88:517-21. 1999
    ..1 and 1.4 for the two regions on chromosome 2. These results are consistent with linkage, but do not provide definitive evidence. We are currently creating a denser map in these regions and have begun genotyping a second sample in COGA...
  17. pmc Genome-wide linkage analysis of 972 bipolar pedigrees using single-nucleotide polymorphisms
    J A Badner
    Department of Psychiatry, University of Chicago, Chicago, IL, USA
    Mol Psychiatry 17:818-26. 2012
    ..Although some linkage findings may be false positives, the results could help prioritize the search for rare variants using whole exome or genome sequencing...
  18. ncbi request reprint Alcoholism susceptibility loci: confirmation studies in a replicate sample and further mapping
    T Foroud
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis 46202, USA
    Alcohol Clin Exp Res 24:933-45. 2000
    ..A previous study reported linkage to chromosomes 1, 2, and 7 in a large data set that consisted of 105 families, each with at least three alcoholic members...
  19. doi request reprint Convergent functional genomics of genome-wide association data for bipolar disorder: comprehensive identification of candidate genes, pathways and mechanisms
    H Le-Niculescu
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, USA
    Am J Med Genet B Neuropsychiatr Genet 150:155-81. 2009
    ..These become prime targets for hypothesis driven follow-up studies, new drug development and personalized medicine approaches...
  20. ncbi request reprint Initial genomic scan of the NIMH genetics initiative bipolar pedigrees: chromosomes 3, 5, 15, 16, 17, and 22
    H J Edenberg
    Indiana University School of Medicine, Indianapolis 46202 5122, USA
    Am J Med Genet 74:238-46. 1997
    ..Thus, several regions showed modest evidence for linkage to bipolar disorder in this initial genomic scan of these chromosomes, including broad regions near previous reports of possible linkage...
  21. ncbi request reprint Towards understanding the schizophrenia code: an expanded convergent functional genomics approach
    H Le-Niculescu
    Laboratory of Neurophenomics, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Am J Med Genet B Neuropsychiatr Genet 144:129-58. 2007
    ..Other pathways are new potential targets for drug development. Lastly, a comparison with our earlier work on bipolar disorder illuminates the significant molecular overlap between schizophrenia and bipolar disorder...
  22. ncbi request reprint Hypothetical quantitative trait loci (QTL) for circadian period of locomotor activity in CXB recombinant inbred strains of mice
    A R Mayeda
    Department of Psychiatry, Indiana University, Indianapolis 46202, USA
    Behav Genet 26:505-11. 1996
    ..There was also a conjunction with a locus determined from QTL analysis of the previously reported tau of wheel running activity in seven CXB RI strains (Schwartz and Zimmerman, 1990)...
  23. ncbi request reprint New quantitative trait loci for the genetic variance in circadian period of locomotor activity between inbred strains of mice
    J R Hofstetter
    Department of Veterans Affairs, Richard L Roudebush Medical Center, Indianapolis, IN 46202, USA
    J Biol Rhythms 18:450-62. 2003
    ..For wheel-running period, the chromosome-wide surveys identified QTL on chromosomes 2 and 13 and one highly suggestive QTL on proximal chromosome 1. The results are compared to other published studies of QTL of circadian period...
  24. pmc Convergent Functional Genomics of bipolar disorder: from animal model pharmacogenomics to human genetics and biomarkers
    H Le-Niculescu
    Laboratory of Neurophenomics, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202 2873, USA
    Neurosci Biobehav Rev 31:897-903. 2007
    ..The CFG approach may also be particularly useful for identification of blood biomarkers of the illness...
  25. ncbi request reprint Family-based study of the association of the dopamine D2 receptor gene (DRD2) with habitual smoking
    L J Bierut
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Med Genet 90:299-302. 2000
    ..There also was no evidence for unequal transmission of DRD2 alleles for the phenotypes "ever smoker" or comorbid alcohol dependence and habitual smoking. This study does not support linkage of the DRD2 with smoking...
  26. ncbi request reprint Suggestive evidence of a locus on chromosome 10p using the NIMH genetics initiative bipolar affective disorder pedigrees
    T Foroud
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Am J Med Genet 96:18-23. 2000
    ..Other chromosomal regions with lod scores over 1.50 for at least one Model Included chromosomes 8 (Model III), 16 (Model III), and 20 (Model I). Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:18-23, 2000..
  27. ncbi request reprint Association of GABRA2 with drug dependence in the collaborative study of the genetics of alcoholism sample
    Arpana Agrawal
    Department of Psychiatry, Washington University in St Louis, St Louis, MO, USA
    Behav Genet 36:640-50. 2006
    ..There was no association with other genes in the GABAA cluster on chromosome 4 with illicit drug dependence...
  28. pmc Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction
    M Ayalew
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA
    Mol Psychiatry 17:887-905. 2012
    ..It also reveals the significant genetic overlap with other major psychiatric disorder domains, suggesting the need for improved nosology...
  29. pmc A risk allele for nicotine dependence in CHRNA5 is a protective allele for cocaine dependence
    Richard A Grucza
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Avenue, Box 8134, St Louis, Missouri 63110, USA
    Biol Psychiatry 64:922-9. 2008
    ..The goal of this study was to examine the association of this variant with cocaine dependence...
  30. ncbi request reprint Stress-induced changes of norepinephrine uptake sites in the locus coeruleus of C57BL/6J and DBA/2J mice: a quantitative autoradiographic study using [3H]-tomoxetine
    B H Hwang
    Department of Anatomy and Psychiatry, Indiana University School of Medicine, Indianapolis 46202, USA
    Neurosci Lett 265:151-4. 1999
    ..Collectively, results of this study and the literature suggest that enhanced NE function in the LC of C57 mice is associated with their susceptibility to stress-induced behavioral depression...
  31. ncbi request reprint A preliminary open-label study of zonisamide treatment for bipolar depression in 10 patients
    Amit Anand
    Department of Psychiatry, Indiana University School of Medicine, IN 46202, USA
    J Clin Psychiatry 66:195-8. 2005
    ..The purpose of this study was to investigate the effectiveness of zonisamide in the treatment of bipolar depression...
  32. ncbi request reprint Association analysis of genes encoding the nociceptin receptor (OPRL1) and its endogenous ligand (PNOC) with alcohol or illicit drug dependence
    Xiaoling Xuei
    Department of Biochemistry and Molecular Biology, Indiana Unviersity School of Medicine, Indianapolis, IN 46202, USA
    Addict Biol 13:80-7. 2008
    ..04-0.05). Secondary analyses suggested that two adjacent SNPs in intron 1 of OPRL1 were marginally associated with opioid dependence (P = 0.05); none of the SNPs in PNOC were associated with opioid dependence...
  33. ncbi request reprint Lack of association of alcohol dependence and habitual smoking with catechol-O-methyltransferase
    Tatiana Foroud
    Indiana University School of Medicine, Indianapolis, Indiana 46202 3002, USA
    Alcohol Clin Exp Res 31:1773-9. 2007
    ....
  34. ncbi request reprint Molecular psychiatry meeting, February 2003, Lake Louise, Canada
    Danielle M Dick
    Department of Psychiatry, Indiana University Medical Center, Indianapolis, Indiana 46202 4887, USA
    Psychiatr Genet 14:183-6. 2004
    ..The host was Bill Byerley (University of California, Irvine, California, USA), and the meeting was supported by Janssen Pharmaceutica and the Department of Psychiatry, University of California, Irvine, California, USA...
  35. pmc A regulatory variation in OPRK1, the gene encoding the kappa-opioid receptor, is associated with alcohol dependence
    Howard J Edenberg
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Hum Mol Genet 17:1783-9. 2008
    ..This indel is, therefore, a functional regulatory variation likely to explain at least part of the association of OPRK1 with alcohol dependence...
  36. pmc A genome-wide association study of alcohol dependence
    Laura J Bierut
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 107:5082-7. 2010
    ..11 and 1.16. Further dissection of the alcoholism phenotype, to disentangle the influence of comorbid substance-use disorders, will be a next step in identifying genetic variants associated with alcohol dependence...
  37. pmc Genome-wide association study of alcohol dependence implicates a region on chromosome 11
    Howard J Edenberg
    Department of Biochemistry, Indiana University School of Medicine, Indianapolis, 46202 5122, USA
    Alcohol Clin Exp Res 34:840-52. 2010
    ..Alcohol dependence is a complex disease, and although linkage and candidate gene studies have identified several genes associated with the risk for alcoholism, these explain only a portion of the risk...
  38. pmc Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations
    Howard J Edenberg
    Indiana University School of Medicine, Indianapolis 46202, USA
    Am J Hum Genet 74:705-14. 2004
    ....
  39. pmc Neuropeptide Y receptor genes are associated with alcohol dependence, alcohol withdrawal phenotypes, and cocaine dependence
    Leah Wetherill
    Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Alcohol Clin Exp Res 32:2031-40. 2008
    ..Additional studies suggest that cocaine may affect NPY expression...
  40. pmc The tachykinin receptor 3 is associated with alcohol and cocaine dependence
    Tatiana Foroud
    Indiana University School of Medicine, Indianapolis, Indiana 46202 3002, USA
    Alcohol Clin Exp Res 32:1023-30. 2008
    ..Pharmacological studies have provided evidence that the administration of NK3R agonists attenuates the intake of alcohol and NK3R can also mediate the acute and chronic behavioral effects of cocaine...
  41. ncbi request reprint Candidate genes, pathways and mechanisms for alcoholism: an expanded convergent functional genomics approach
    Z A Rodd
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Pharmacogenomics J 7:222-56. 2007
    ..In conjunction with a higher reactivity to its rewarding effects, they may able to ingest enough of this nonspecific drug for a strong hedonic and addictive effect to occur...
  42. ncbi request reprint Association of NFKB1, which encodes a subunit of the transcription factor NF-kappaB, with alcohol dependence
    Howard J Edenberg
    Indiana University School of Medicine, Indianapolis, IN, USA
    Hum Mol Genet 17:963-70. 2008
    ..Thus, variations in NFKB1 appear to affect the risk for alcoholism, particularly contributing to an earlier onset of the disease...
  43. pmc Evidence of association between brain-derived neurotrophic factor gene and bipolar disorder
    Lixiang Liu
    Indiana University, Indianapolis, Indiana 46202 3002, USA
    Psychiatr Genet 18:267-74. 2008
    ..Growing evidence suggests that BDNF is involved in the pathophysiology of mood disorders...
  44. ncbi request reprint Marital status, alcohol dependence, and GABRA2: evidence for gene-environment correlation and interaction
    Danielle M Dick
    Department of Psychiatry, Washington University in St Louis, Box 8134, 660 South Euclid Ave, St Louis, MO 63130, USA
    J Stud Alcohol 67:185-94. 2006
    ..This article explores how this genetic risk factor interacts with marital status, another factor previously shown to be associated with the risk for alcohol dependence...
  45. pmc Evidence for association between polymorphisms in the cannabinoid receptor 1 (CNR1) gene and cannabis dependence
    Arpana Agrawal
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Med Genet B Neuropsychiatr Genet 150:736-40. 2009
    ..05) and rs806380 (P = 0.009)]. Haplotype analyses revealed the association to be largely driven by the SNP rs806380. These results suggest a role for the cannabinoid receptor 1 gene in cannabis dependence...
  46. ncbi request reprint Association of GABA(A) receptors and alcohol dependence and the effects of genetic imprinting
    Jiuzhou Song
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, Indiana 46202 5122, USA
    Am J Med Genet B Neuropsychiatr Genet 117:39-45. 2003
    ..Maternal transmissions provided no evidence for association. These data are consistent with an association between the expressed alleles in the GABA(A)-gene cluster on chromosome 15 and alcoholism that is modulated by genetic imprinting...
  47. ncbi request reprint Molecular genetics of bipolar disorder
    E P Hayden
    Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, IN 46202 4887, USA
    Genes Brain Behav 5:85-95. 2006
    ..We conclude with suggestions for strategies that may help clarify the genetic bases of this complex illness...
  48. pmc Item response modeling of DSM-IV mania symptoms in two representative US epidemiological samples
    A Agrawal
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Psychol Med 40:1549-58. 2010
    ..There is considerable debate surrounding the effective measurement of DSM-IV symptoms used to assess manic disorders in epidemiological samples...
  49. ncbi request reprint Effects of cholinesterase inhibitors on the secretion of beta-amyloid precursor protein in cell cultures
    D K Lahiri
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis 46202, USA
    Ann N Y Acad Sci 826:416-21. 1997
    ....
  50. pmc Multiple-domain predictors of problematic alcohol use in young adulthood
    John R Kramer
    Department of Psychiatry, Medical Education Building, University of Iowa School of Medicine, 500 Newton Road, Iowa City, Iowa 52242 1000, USA
    J Stud Alcohol Drugs 69:649-59. 2008
    ..The goal of this study was to identify predictors of problematic young adult alcohol use...
  51. pmc A comparison of diagnoses obtained from in-person and telephone interviews, using the semi-structured assessment for the genetics of alcoholism (SSAGA)
    John R Kramer
    Department of Psychiatry, Medical Education Building, University of Iowa School of Medicine, 500 Newton Road, Iowa City, Iowa 52242 1000, USA
    J Stud Alcohol Drugs 70:623-7. 2009
    ....
  52. ncbi request reprint Seeking the connections: alcoholism and our genes
    John I Nurnberger
    Indiana University School of Medicine, USA
    Sci Am 296:46-53. 2007
  53. ncbi request reprint Evidence of common and specific genetic effects: association of the muscarinic acetylcholine receptor M2 (CHRM2) gene with alcohol dependence and major depressive syndrome
    Jen C Wang
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Hum Mol Genet 13:1903-11. 2004
    ..These findings provide strong evidence that variants within or close to the CHRM2 locus influence risk for two common psychiatric disorders...
  54. ncbi request reprint Comparison of psychiatric diagnoses from interview reports with those from best-estimate procedures
    Kathleen K Bucholz
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8134, St Louis, Missouri 63110 1093, USA
    J Stud Alcohol 67:157-68. 2006
    ....
  55. ncbi request reprint The search for genetic risk factors associated with suicidal behavior
    Victor Hesselbrock
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, Connecticut, USA
    Alcohol Clin Exp Res 28:70S-76S. 2004
    ....
  56. ncbi request reprint Identification of a locus on mouse chromosome 17 associated with high-affinity choline uptake using BXD recombinant inbred mice and quantitative trait loci analysis
    B J Tarricone
    Department of Psychiatry and Program in Medical Neurobiology, Indiana University School of Medicine, Indianapolis 46202, USA
    Genomics 27:161-4. 1995
    ..05 and P < 0.01. These data suggest that at least one locus located on mouse chromosome 17 near or between 6 and 13 cM from the centromere influences HACU in the striatum and possibly the frontal cortex and hippocampus of the mouse...
  57. ncbi request reprint Developmental expression of the beta-amyloid precursor protein and heat-shock protein 70 in the cerebral hemisphere region of the rat brain
    D K Lahiri
    Laboratory of Molecular Neurogenetics, Institute of Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46202 4887, USA
    Ann N Y Acad Sci 965:324-33. 2002
    ..These initial results suggest that APP may play an important role in the early development of the rat brain and the alcohol-preferring trait may influence APP processing in the developing brain...
  58. ncbi request reprint A comparison of alcohol-induced and independent depression in alcoholics with histories of suicide attempts
    U W Preuss
    Department of Psychiatry, University of California, San Diego 92161 2002, USA
    J Stud Alcohol 63:498-502. 2002
    ....
  59. pmc A principal components analysis of the abbreviated Desires for Alcohol Questionnaire (DAQ)
    John R Kramer
    Department of Psychiatry, Medical Education Building, University of Iowa School of Medicine, 500 Newton Road, Iowa City, Iowa 52242 1000, USA
    J Stud Alcohol Drugs 71:150-5. 2010
    ..The aim of this study was to examine the abbreviated Desires for Alcohol Questionnaire (DAQ) with respect to component structure and concurrent validity...
  60. doi request reprint Genome-wide parametric linkage analyses of 644 bipolar pedigrees suggest susceptibility loci at chromosomes 16 and 20
    Jessica Ross
    Department of Psychiatry, University of California, San Francisco, CA 94132 0984, USA
    Psychiatr Genet 18:191-8. 2008
    ..Our aim is to map chromosomal regions that harbor loci that increase susceptibility to bipolar disorder...
  61. pmc Development and validation of the high-quality 'rapid method for swab' to genotype the HTTLPR serotonin transporter (SLC6A4) promoter polymorphism
    Bryan Maloney
    Laboratory of Molecular Neurogenetics, Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Psychiatr Genet 19:72-82. 2009
    ..Samples collected have been shown to produce usable DNA after shipment through conventional mail. The DNA produced by rapid elution of these swabs in chaotropic buffers is, however, of limited quality and low purity...
  62. ncbi request reprint Is there a genetic relationship between alcoholism and depression?
    John I Nurnberger
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Alcohol Res Health 26:233-40. 2002
    ..This suggests that a gene or genes on chromosome 1 may predispose some people to alcoholism and others to depression (which may be alcohol induced)...
  63. pmc Genomewide linkage analyses of bipolar disorder: a new sample of 250 pedigrees from the National Institute of Mental Health Genetics Initiative
    Danielle M Dick
    Institute of Psychiatric Research, Indiana University School of Medicine, 791 Union Drive, Indianapolis, IN 46202 4887, USA
    Am J Hum Genet 73:107-14. 2003
    ..10), on chromosomes 2p, 3q, and 8q. This study, which is based on the largest linkage sample for bipolar disorder analyzed to date, indicates that several genes contribute to bipolar disorder...
  64. doi request reprint Familial aggregation of postpartum mood symptoms in bipolar disorder pedigrees
    Jennifer L Payne
    Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Bipolar Disord 10:38-44. 2008
    ..We sought to determine if postpartum mood symptoms and depressive episodes exhibit familial aggregation in bipolar I pedigrees...
  65. ncbi request reprint Linkage for platelet monoamine oxidase (MAO) activity: results from a replication sample
    Nancy L Saccone
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Alcohol Clin Exp Res 26:603-9. 2002
    ..These families were recruited as part of the Collaborative Study on the Genetics of Alcoholism (COGA)...
  66. ncbi request reprint A genomic scan for habitual smoking in families of alcoholics: common and specific genetic factors in substance dependence
    Laura Jean Bierut
    School of Medicine, Washington University School of Medicine, 4940 Children s Place, St Louis, MO 63110, USA
    Am J Med Genet A 124:19-27. 2004
    ..Finally, there is also evidence of an area on chromosome 2 that may reflect a common genetic vulnerability locus to both habitual smoking and alcohol dependence...
  67. ncbi request reprint Rapid switching of mood in families with multiple cases of bipolar disorder
    Dean F MacKinnon
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Arch Gen Psychiatry 60:921-8. 2003
    ..Phenomena in the bipolar spectrum, including rapid cycling, cyclothymia, and affective instability of borderline personality, may be important markers of etiologic heterogeneity. Rapid switching of mood may be central to these phenomena...
  68. ncbi request reprint The relationship between parental alcoholism and adolescent psychopathology: a systematic examination of parental comorbid psychopathology
    Christine McCauley Ohannessian
    Department of Individual and Family Studies, University of Delaware, Newark, DE 19716, USA
    J Abnorm Child Psychol 32:519-33. 2004
    ..These findings underscore the importance of considering parental comorbid psychopathology when examining the relationship between parental alcoholism and offspring adjustment...
  69. ncbi request reprint Mood-incongruent psychotic features in bipolar disorder: familial aggregation and suggestive linkage to 2p11-q14 and 13q21-33
    Fernando S Goes
    Johns Hopkins Hospital, 600 North Wolfe St, Meyer 4 119, Baltimore, MD 21287 7419, USA
    Am J Psychiatry 164:236-47. 2007
    ..This study attempts to characterize clinical correlates, familial aggregation, and genetic linkage in subjects with these features...
  70. ncbi request reprint Lack of support for a genetic association of the XBP1 promoter polymorphism with bipolar disorder in probands of European origin
    Sven Cichon
    Nat Genet 36:783-4; author reply 784-5. 2004
  71. pmc Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q
    Matthew B McQueen
    Harvard School of Public Health, Department of Epidemiology, Boston, MA 02115, USA
    Am J Hum Genet 77:582-95. 2005
    ..Our results establish genomewide significant linkage to BP on chromosomes 6q and 8q, which provides solid information to guide future gene-finding efforts that rely on fine-mapping and association approaches...
  72. pmc Linkage scan for quantitative traits identifies new regions of interest for substance dependence in the Collaborative Study on the Genetics of Alcoholism (COGA) sample
    Arpana Agrawal
    Washington University School of Medicine, St Louis, MO 63110, USA
    Drug Alcohol Depend 93:12-20. 2008
    ..0 on chromosome 2 (3.2, 234 cM), 10 (2.4 and 2.6 at 60 cM and 116 cM) and 13 (2.1 at 64 cM). These regions may harbor genes that contribute to the biological basis of alcohol and drug dependence...
  73. ncbi request reprint Association of rapid mood switching with panic disorder and familial panic risk in familial bipolar disorder
    Dean F MacKinnon
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Meyer 3 181, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Am J Psychiatry 160:1696-8. 2003
    ..The authors investigated whether comorbidity of bipolar disorder and panic disorder is associated with rapid mood switching in families with a high rate of bipolar disorder...
  74. ncbi request reprint Long-term stability of alcohol and other substance dependence diagnoses and habitual smoking: an evaluation after 5 years
    Robert Culverhouse
    Department of Internal Medicine, Washington University in St Louis School of Medicine, St Louis, MO 63110 1026, USA
    Arch Gen Psychiatry 62:753-60. 2005
    ..A major criterion to validate diagnoses is stability over time...
  75. ncbi request reprint Loci on chromosomes 6q and 6p interact to increase susceptibility to bipolar affective disorder in the national institute of mental health genetics initiative pedigrees
    Thomas G Schulze
    Genetic Basis of Mood and Anxiety Disorders, Mood and Anxiety Program, Bethesda, USA
    Biol Psychiatry 56:18-23. 2004
    ....
  76. ncbi request reprint Prospective evaluation of the four DSM-IV criteria for alcohol abuse in a large population
    Marc A Schuckit
    VA San Diego Healthcare System, University of California, San Diego, CA, USA
    Am J Psychiatry 162:350-60. 2005
    ....
  77. ncbi request reprint Genome scan of the fifty-six bipolar pedigrees from the NIMH genetics initiative replication sample: chromosomes 4, 7, 9, 18, 19, 20, and 21
    Virginia L Willour
    The Johns Hopkins University, Baltimore, Maryland 21287, USA
    Am J Med Genet B Neuropsychiatr Genet 121:21-7. 2003
    ..38, which exceeds standard criteria for suggestive linkage, and a corresponding parametric HLOD score of 2.98. The combined analysis did not provide further support for linkage to 4q32 and 4q35...
  78. pmc Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder
    Ricardo Segurado
    Neuropsychiatric Genetics Unit, Department of Genetics, Trinity College, Dublin 2, Ireland
    Am J Hum Genet 73:49-62. 2003
    ..We note that meta-analysis can sometimes provide support for linkage but cannot disprove linkage in any candidate region...
  79. ncbi request reprint Genome-wide scan and conditional analysis in bipolar disorder: evidence for genomic interaction in the National Institute of Mental Health genetics initiative bipolar pedigrees
    Melvin G McInnis
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21287 7463, USA
    Biol Psychiatry 54:1265-73. 2003
    ..The first 97 pedigrees showed evidence of linkage to chromosomes 1, 6, 7, 10, 16, and 22 (Nurnberger et al 1997). An additional 56 bipolar families have been genotyped, and the combined sample of 153 pedigrees studied...
  80. ncbi request reprint Reproductive cycle-associated mood symptoms in women with major depression and bipolar disorder
    Jennifer L Payne
    Department of Psychiatry, Women s Mood Disorders Center, The Johns Hopkins Hospital, 600 North Wolfe Street Meyer 3 181, Baltimore, MD 21287 7381, United States
    J Affect Disord 99:221-9. 2007
    ..We hypothesized that symptoms would correlate with each other across a woman's reproductive life span in both major depression (MDD) and bipolar I disorder (BP)...
  81. ncbi request reprint Temperamental fearfulness in childhood and the serotonin transporter promoter region polymorphism: a multimethod association study
    Elizabeth P Hayden
    Department of Psychology, University of Western Ontario, London, Ontario, Canada
    Psychiatr Genet 17:135-42. 2007
    ..Previous research indicates that the serotonin transporter promoter region polymorphism is a candidate gene for such traits...
  82. ncbi request reprint Teenagers are right--parents do not know much: an analysis of adolescent-parent agreement on reports of adolescent substance use, abuse, and dependence
    Sherri L Fisher
    Washington University School of Medicine, St Louis, Missouri 63110, USA
    Alcohol Clin Exp Res 30:1699-710. 2006
    ..The purpose of this study was to analyze correspondence between adolescent and parent reports of adolescent substance use and abuse or dependence...
  83. pmc Early-emerging cognitive vulnerability to depression and the serotonin transporter promoter region polymorphism
    Elizabeth P Hayden
    University of Western Ontario, Department of Psychology, London, Ontario Canada N6A 5C2
    J Affect Disord 107:227-30. 2008
    ..However, the effects of this genotype on measures of stress sensitivity are poorly understood. Therefore, this study examined whether 5-HTTLPR genotype was associated with negative information processing biases in early childhood...
  84. ncbi request reprint A comparison of factors associated with substance-induced versus independent depressions
    Marc A Schuckit
    Department of Psychiatry 116A, University of California, San Diego, California, USA
    J Stud Alcohol Drugs 68:805-12. 2007
    ....
  85. ncbi request reprint Parental substance use consequences and adolescent psychopathology
    Christine McCauley Ohannessian
    Department of Individual and Family Studies, University of Delaware, Newark, Delaware 19716 3301, USA
    J Stud Alcohol 65:725-30. 2004
    ..This study examines the relationship between parental substance use consequences and adolescent psychological problems by gender of the adolescent and gender of the parent...
  86. ncbi request reprint Patterns of regional brain activity in alcohol-dependent subjects
    Elizabeth P Hayden
    University of Western Ontario, London, Ontario, Canada
    Alcohol Clin Exp Res 30:1986-91. 2006
    ..It is also unclear whether psychiatric comorbidity in AD subjects accounts for additional variance in frontal asymmetry, beyond a diagnosis of AD alone...
  87. ncbi request reprint Possible mirtazapine-induced rhabdomyolysis
    Amaresh B Khandat
    Ann Pharmacother 38:1321. 2004
  88. doi request reprint A multimethod investigation of the behavioral activation system in bipolar disorder
    Elizabeth P Hayden
    Department of Psychology, University of Western Ontario, London, Ontario, N6A 5C2, Canada
    J Abnorm Psychol 117:164-70. 2008
    ..Implications of the findings for future research on BPD vulnerability are described...

Research Grants13

  1. Adolescents at High Risk for Familial Bipolar Disorder
    John Nurnberger; Fiscal Year: 2007
    ..The ethical implications of this research will be studied by examining the effects of participation and the effect on self-esteem due to high- risk status. ..
  2. A COLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDER
    John Nurnberger; Fiscal Year: 2007
    ..Analysis of the existing sib pair families plus this large set of cases and controls should permit the confirmation of several vulnerability genes during this grant period. ..
  3. COLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDER
    John Nurnberger; Fiscal Year: 2001
    ..Genotypes will be shared with a consortium of investigators studying linkage in bipolar illness. Cell lines and interview data will be made freely available to the scientific community. ..
  4. Adolescents at High Risk for Familial Bipolar Disorder
    John Nurnberger; Fiscal Year: 2009
    ..The ethical implications of this research will be studied by examining the effects of participation and the effect on self-esteem due to high- risk status. ..