H Nakshatri

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. ncbi request reprint NF-kappaB promotes breast cancer cell migration and metastasis by inducing the expression of the chemokine receptor CXCR4
    Gregory Helbig
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Biol Chem 278:21631-8. 2003
  2. doi request reprint Epithelial-to-mesenchymal transition and ovarian tumor progression induced by tissue transglutaminase
    Minghai Shao
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Cancer Res 69:9192-201. 2009
  3. pmc PROGmiR: a tool for identifying prognostic miRNA biomarkers in multiple cancers using publicly available data
    Chirayu Pankaj Goswami
    Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, 410 W 10th Street, Indianapolis, IN, 46202, USA
    J Clin Bioinforma 2:23. 2012
  4. pmc Interplay between estrogen receptor and AKT in Estradiol-induced alternative splicing
    Poornima Bhat-Nakshatri
    Departments of Surgery, Indiana University School of Medicine, 980 West Walnut Street, Indianapolis, IN 46202, USA
    BMC Med Genomics 6:21. 2013
  5. pmc Persistent upregulation of U6:SNORD44 small RNA ratio in the serum of breast cancer patients
    Hitesh N Appaiah
    Department of Surgery, Indiana University School of Medicine, West Walnut Street, Indianapolis, IN 46202, USA
    Breast Cancer Res 13:R86. 2011
  6. pmc A large, consistent plasma proteomics data set from prospectively collected breast cancer patient and healthy volunteer samples
    Catherine P Riley
    Bindley Bioscience Center, Purdue University, West Lafayette, IN, USA
    J Transl Med 9:80. 2011
  7. pmc CD44+/CD24- breast cancer cells exhibit enhanced invasive properties: an early step necessary for metastasis
    Carol Sheridan
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Breast Cancer Res 8:R59. 2006
  8. pmc SLUG/SNAI2 and tumor necrosis factor generate breast cells with CD44+/CD24- phenotype
    Poornima Bhat-Nakshatri
    Department of Surgery, Indiana University School of Medicine, West Walnut Street, Indianapolis, IN 46202, USA
    BMC Cancer 10:411. 2010
  9. ncbi request reprint Antitumor agent parthenolide reverses resistance of breast cancer cells to tumor necrosis factor-related apoptosis-inducing ligand through sustained activation of c-Jun N-terminal kinase
    Harikrishna Nakshatri
    Department of Surgery, Indiana University School of Medicine, Indianapolis 46202, USA
    Oncogene 23:7330-44. 2004
  10. doi request reprint Intrinsic subtype-associated changes in the plasma proteome in breast cancer
    Harikrishna Nakshatri
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA
    Proteomics Clin Appl 3:1305-13. 2009

Research Grants

Detail Information

Publications66

  1. ncbi request reprint NF-kappaB promotes breast cancer cell migration and metastasis by inducing the expression of the chemokine receptor CXCR4
    Gregory Helbig
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Biol Chem 278:21631-8. 2003
    ..Taken together, these results implicate NF-kappaB in the migration and the organ-specific homing of metastatic breast cancer cells...
  2. doi request reprint Epithelial-to-mesenchymal transition and ovarian tumor progression induced by tissue transglutaminase
    Minghai Shao
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Cancer Res 69:9192-201. 2009
    ..Highly expressed in ovarian tumors, TG2 promotes EMT and enhances ovarian tumor metastasis by activating oncogenic signaling...
  3. pmc PROGmiR: a tool for identifying prognostic miRNA biomarkers in multiple cancers using publicly available data
    Chirayu Pankaj Goswami
    Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, 410 W 10th Street, Indianapolis, IN, 46202, USA
    J Clin Bioinforma 2:23. 2012
    ..abstract:..
  4. pmc Interplay between estrogen receptor and AKT in Estradiol-induced alternative splicing
    Poornima Bhat-Nakshatri
    Departments of Surgery, Indiana University School of Medicine, 980 West Walnut Street, Indianapolis, IN 46202, USA
    BMC Med Genomics 6:21. 2013
    ..The endogenous targets of ERα:estradiol (E2)-mediated alternative splicing and the influence of extracellular kinases that phosphorylate ERα on E2-induced splicing are unknown...
  5. pmc Persistent upregulation of U6:SNORD44 small RNA ratio in the serum of breast cancer patients
    Hitesh N Appaiah
    Department of Surgery, Indiana University School of Medicine, West Walnut Street, Indianapolis, IN 46202, USA
    Breast Cancer Res 13:R86. 2011
    ..This investigation addresses two issues that impact their utility: a) appropriate normalization controls and b) whether their altered levels persist in patients who are clinically free of the disease...
  6. pmc A large, consistent plasma proteomics data set from prospectively collected breast cancer patient and healthy volunteer samples
    Catherine P Riley
    Bindley Bioscience Center, Purdue University, West Lafayette, IN, USA
    J Transl Med 9:80. 2011
    ..Variability of plasma sample collection and of proteomics technology platforms has been detrimental to generation of large proteomic profile datasets from human biospecimens...
  7. pmc CD44+/CD24- breast cancer cells exhibit enhanced invasive properties: an early step necessary for metastasis
    Carol Sheridan
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Breast Cancer Res 8:R59. 2006
    ..The aim of this study was to investigate whether this subpopulation of cancer cells has the unique ability to invade, home, and proliferate at sites of metastasis...
  8. pmc SLUG/SNAI2 and tumor necrosis factor generate breast cells with CD44+/CD24- phenotype
    Poornima Bhat-Nakshatri
    Department of Surgery, Indiana University School of Medicine, West Walnut Street, Indianapolis, IN 46202, USA
    BMC Cancer 10:411. 2010
    ..However, whether all genes that induce EMT confer the CD44+/CD24- phenotype is unknown. We hypothesized that only a subset of genes associated with EMT generates CD44+/CD24- cells...
  9. ncbi request reprint Antitumor agent parthenolide reverses resistance of breast cancer cells to tumor necrosis factor-related apoptosis-inducing ligand through sustained activation of c-Jun N-terminal kinase
    Harikrishna Nakshatri
    Department of Surgery, Indiana University School of Medicine, Indianapolis 46202, USA
    Oncogene 23:7330-44. 2004
    ..These results identify a new antitumor activity of parthenolide, which can be exploited to reverse resistance of cancer cells to TRAIL, particularly those with elevated XIAP levels...
  10. doi request reprint Intrinsic subtype-associated changes in the plasma proteome in breast cancer
    Harikrishna Nakshatri
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA
    Proteomics Clin Appl 3:1305-13. 2009
    ..These results reveal intrinsic subtype specific changes in the plasma proteome that may influence tumor progression as well as the systemic effects of cancer...
  11. ncbi request reprint Breast cancer stem cells and intrinsic subtypes: controversies rage on
    Harikrishna Nakshatri
    Department of Surgery, Indiana University School of Medicine, 1044 West Walnut Street, Indianapolis, IN 46202, USA
    Curr Stem Cell Res Ther 4:50-60. 2009
    ....
  12. ncbi request reprint FOXA1 as a therapeutic target for breast cancer
    Harikrishna Nakshatri
    Indiana University School of Medicine, Departments of Surgery, Biochemistry and Molecular Biology, Walther Oncology Center, Indianapolis, IN 46202, USA
    Expert Opin Ther Targets 11:507-14. 2007
    ..This article reviews possible roles of FOXA family transcription factors in breast cancer initiation, hormone dependency and speculates on the potential of FOXA1 as a therapeutic target...
  13. ncbi request reprint The orphan receptor COUP-TFII regulates G2/M progression of breast cancer cells by modulating the expression/activity of p21(WAF1/CIP1), cyclin D1, and cdk2
    H Nakshatri
    Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Biochem Biophys Res Commun 270:1144-53. 2000
    ..Furthermore, these results reveal an important physiological function of COUP-TFII, which correlates with its ability to induce gene expression rather than modulation of nuclear receptor activity...
  14. pmc Multiple parameters determine the specificity of transcriptional response by nuclear receptors HNF-4, ARP-1, PPAR, RAR and RXR through common response elements
    H Nakshatri
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Nucleic Acids Res 26:2491-9. 1998
    ....
  15. doi request reprint FOXA1 in breast cancer
    Harikrishna Nakshatri
    Departments of Surgery, Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Expert Rev Mol Med 11:e8. 2009
    ..Additionally, we discuss modulators of FOXA1 function, ERalpha-FOXA1-GATA3 downstream targets, and potential therapeutic agents that may increase differentiation through FOXA1...
  16. pmc Tumour necrosis factor and PI3-kinase control oestrogen receptor alpha protein level and its transrepression function
    P Bhat-Nakshatri
    Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Br J Cancer 90:853-9. 2004
    ..From these results, we propose that TNFalpha expression or PI3-kinase activation lead to reduced levels of ERalpha protein in cancer cells and corresponding loss of transrepression function and acquisition of an invasive phenotype...
  17. ncbi request reprint Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance
    R A Campbell
    Department of Surgery, Indiana University School of Medicine, Indianapolis 46202, USA
    J Biol Chem 276:9817-24. 2001
    ..Taken together, these results define a molecular link between activation of the PI 3-kinase/AKT survival pathways, hormone-independent activation of ERalpha, and inhibition of tamoxifen-induced apoptotic regression...
  18. pmc Constitutive activation of NF-kappaB during progression of breast cancer to hormone-independent growth
    H Nakshatri
    Department of Surgery, Indiana University School of Medicine, Indianapolis 46202, USA
    Mol Cell Biol 17:3629-39. 1997
    ....
  19. ncbi request reprint Transformation of interleukin-3-dependent cells without participation of Stat5/bcl-xL: cooperation of akt with raf/erk leads to p65 nuclear factor kappaB-mediated antiapoptosis involving c-IAP2
    V M Gelfanov
    Walther Cancer Institute and Division of Hematology/Oncology, Department of Medicine, Indiana University School of Medicine and VA Medical Center, Indianapolis, IN 46202, USA
    Blood 98:2508-17. 2001
    ....
  20. ncbi request reprint NF-kappaB represses E-cadherin expression and enhances epithelial to mesenchymal transition of mammary epithelial cells: potential involvement of ZEB-1 and ZEB-2
    H L Chua
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
    Oncogene 26:711-24. 2007
    ..MCF10A cells chronically exposed to tumor necrosis factor alpha (TNFalpha), a potent NF-kappaB inducer, also exhibited the EMT-like phenotype and ZEB-1/ZEB-2 induction, both of which were reversed following TNFalpha withdrawal...
  21. ncbi request reprint Repression of GADD153/CHOP by NF-kappaB: a possible cellular defense against endoplasmic reticulum stress-induced cell death
    S Nozaki
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Oncogene 20:2178-85. 2001
    ..These results establish a correlation between repression of pro-apoptotic genes by NF-kappaB and increased cell survival during ER stress as well as identify a distinct NF-kappaB regulated cell survival pathway...
  22. ncbi request reprint The sesquiterpene lactone parthenolide in combination with docetaxel reduces metastasis and improves survival in a xenograft model of breast cancer
    Christopher J Sweeney
    Department of Medicine, Indiana University School of Medicine, Indianapolis, USA
    Mol Cancer Ther 4:1004-12. 2005
    ..These results for the first time reveal the significant in vivo chemosensitizing properties of parthenolide in the metastatic breast cancer setting and support the contention that metastases are very reliant on activation of NF-kappaB...
  23. ncbi request reprint Forkhead box A1 expression in breast cancer is associated with luminal subtype and good prognosis
    M A Thorat
    Department of Pathology and Laboratory Medicine, IU School of Medicine, Indianapolis, IN 46202, USA
    J Clin Pathol 61:327-32. 2008
    ..This study explored the FOXA1 relationship with luminal and basal breast cancer subtypes, proliferation markers, and survival in breast cancer patients who had received similar treatment...
  24. ncbi request reprint The p160 family coactivators regulate breast cancer cell proliferation and invasion through autocrine/paracrine activity of SDF-1alpha/CXCL12
    Hiromitsu Kishimoto
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Carcinogenesis 26:1706-15. 2005
    ..These results also provide a molecular explanation for recent observations linking co-overexpression of coactivators and her2/neu with poor prognosis: coactivators increase SDF-1alpha expression whereas her2/neu stabilize CXCR4 protein...
  25. pmc Prognosis of hormone-dependent breast cancers: implications of the presence of dysfunctional transcriptional networks activated by insulin via the immune transcription factor T-bet
    Kasi McCune
    Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Cancer Res 70:685-96. 2010
    ....
  26. ncbi request reprint Restoring chemotherapy and hormone therapy sensitivity by parthenolide in a xenograft hormone refractory prostate cancer model
    Rajasubramaniam Shanmugam
    Department of Medicine, Indiana University, Indianapolis, Indiana, USA
    Prostate 66:1498-511. 2006
    ..Nuclear Factor kappa B (NFkappaB) is a eukaryotic transcription factor that is constitutively active in human cancers and can be inhibited by the naturally occurring sesquiterpene lactone, parthenolide (P)...
  27. doi request reprint Control of EVI-1 oncogene expression in metastatic breast cancer cells through microRNA miR-22
    J B Patel
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
    Oncogene 30:1290-301. 2011
    ..Identifying such metastasis-specific oncogenic pathways may help to manipulate tumor behavior and aid in the design of more effective targeted therapies...
  28. ncbi request reprint Fusion AML1 transcript in a radiation-associated leukemia results in a truncated inhibitory AML1 protein
    R Hromas
    Indiana University Cancer Center, Indianapolis, Indiana 46202, USA
    Blood 97:2168-70. 2001
    ..This fusion AML1 protein functions as an inhibitor of the normal AML1 protein. (Blood. 2001;97:2168-2170)..
  29. doi request reprint Oestrogen-receptor-positive breast cancer: towards bridging histopathological and molecular classifications
    S Badve
    Department of Pathology and Laboratory Medicine, and Internal Medicine, Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN, USA
    J Clin Pathol 62:6-12. 2009
    ..A detailed understanding of these areas will permit better classification and a personalised approach to management of ER-positive breast cancers...
  30. ncbi request reprint Negative regulation of chemokine receptor CXCR4 by tumor suppressor p53 in breast cancer cells: implications of p53 mutation or isoform expression on breast cancer cell invasion
    S A Mehta
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Oncogene 26:3329-37. 2007
    ..We propose that p53 rescue drugs either alone or in combination with chemotherapeutic drugs may be effective in reducing CXCR4-mediated metastasis...
  31. ncbi request reprint FOXA1 expression in breast cancer--correlation with luminal subtype A and survival
    Sunil Badve
    Department of Pathology, Indiana University School of Medicine, Indianapolis, USA
    Clin Cancer Res 13:4415-21. 2007
    ..It segregates with genes that characterize the luminal subtypes in DNA microarray analyses. The utility of FOXA1 as a possible independent prognostic factor has not been determined in breast cancers...
  32. pmc Tissue transglutaminase protects epithelial ovarian cancer cells from cisplatin-induced apoptosis by promoting cell survival signaling
    Liyun Cao
    Department of Medicine, Richard L Roudebush Veterans Affairs Medical Center, Indiana University School of Medicine, 535 Barnhill Drive, RT 473, Indianapolis, IN 46202, USA
    Carcinogenesis 29:1893-900. 2008
    ..Our data show that TG2 prevents apoptosis induced by cisplatin by activating the NF-kappaB survival pathway in ovarian cancer cells...
  33. pmc Effects of HIV protease inhibitor ritonavir on Akt-regulated cell proliferation in breast cancer
    Anjaiah Srirangam
    Department of Medicine, Indiana University, Indianapolis, Indiana 46202, USA
    Clin Cancer Res 12:1883-96. 2006
    ..Ritonavir may be of interest for breast cancer therapeutics and its efficacy may be increased by sustained exposure or Hsp90 RNA interference...
  34. ncbi request reprint Identification of signal transduction pathways involved in constitutive NF-kappaB activation in breast cancer cells
    Poornima Bhat-Nakshatri
    Walther Oncology Center, Indiana University School of Medicine, Indianapolis, Indiana, IN 46202, USA
    Oncogene 21:2066-78. 2002
    ....
  35. ncbi request reprint Amplified in breast cancer 1 expression in breast cancer
    M A Thorat
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Histopathology 53:634-41. 2008
    ..The aim was to analyse AIB1 expression by immunohistochemistry and study its correlations with other prognostic variables in breast cancer and its effect on survival...
  36. doi request reprint NF-kappaB inhibition in human hepatocellular carcinoma and its potential as adjunct to sorafenib based therapy
    Jian Min Wu
    Department of Surgery, Indiana University School of Medicine, 1001 W 10th Street, Indianapolis, IN 46202, USA
    Cancer Lett 278:145-55. 2009
    ....
  37. doi request reprint A water-soluble parthenolide analogue suppresses in vivo prostate cancer growth by targeting NFkappaB and generating reactive oxygen species
    Rajasubramaniam Shanmugam
    Department of Medicine, Indiana University, Indianapolis, Indiana, USA
    Prostate 70:1074-86. 2010
    ..To characterize the molecular changes associated with DMAPT-induced prostate cancer cell death and its in vivo activity...
  38. pmc Interleukin-1 alpha promotes tumor growth and cachexia in MCF-7 xenograft model of breast cancer
    Suresh Kumar
    Departments of Surgery, Indiana University School of Medicine, Indianapolis 46202, USA
    Am J Pathol 163:2531-41. 2003
    ..Taken together, these results suggest that cancer cell-derived cytokines, such as IL-1 alpha, induce cachexia by affecting leptin-dependent metabolic pathways...
  39. ncbi request reprint Cloning of BRAK, a novel divergent CXC chemokine preferentially expressed in normal versus malignant cells
    R Hromas
    Department of Hematology and Oncology, Walther Oncology Center, Indiana University Medical Center, R4 202, 1044 W Walnut Street, Indianapolis, Indiana, 46202
    Biochem Biophys Res Commun 255:703-6. 1999
    ..BRAK is expressed ubiquitously and highly in normal tissue. However, it was expressed in only 2 of 18 cancer cell lines. BRAK is located on human chromosome 5q31...
  40. ncbi request reprint NF-kappaB and breast cancer
    Harikrishna Nakshatri
    Indiana University School of Medicine, Walther Cancer Institute, Indianapolis, USA
    Curr Probl Cancer 26:282-309. 2002
  41. ncbi request reprint Nuclear factor-kappaB is constitutively activated in prostate cancer in vitro and is overexpressed in prostatic intraepithelial neoplasia and adenocarcinoma of the prostate
    Christopher Sweeney
    Department of Medicine, Indiana University, Indianapolis, Indiana 46202, USA
    Clin Cancer Res 10:5501-7. 2004
    ..The transcription factor nuclear factor-kappaB (NF-kappaB) promotes the production of angiogenic, antiapoptotic, and prometastatic factors that are involved in carcinogenesis...
  42. ncbi request reprint The platelet-derived growth factor receptor alpha is destabilized by geldanamycins in cancer cells
    Daniela Matei
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 282:445-53. 2007
    ..These results show that 17-AAG promotes PDGFRalpha degradation selectively in transformed cells. Thus, not only mutated tyrosine kinases but also overexpressed receptors in cancer cells can be targeted by 17-AAG...
  43. pmc Subcellular localization of activated AKT in estrogen receptor- and progesterone receptor-expressing breast cancers: potential clinical implications
    Sunil Badve
    Department of Pathology and Internal Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Am J Pathol 176:2139-49. 2010
    ..These results suggest that subcellular localization of activated AKT plays a significant role in determining its function in breast cancer, which in part is dependent on TCL1B expression...
  44. ncbi request reprint Parthenolide and sulindac cooperate to mediate growth suppression and inhibit the nuclear factor-kappa B pathway in pancreatic carcinoma cells
    Michele T Yip-Schneider
    Department of Surgery, Indiana University School of Medicine, Room 041, Building R4, 1044 West Walnut Street, Indianapolis, IN 46202, USA
    Mol Cancer Ther 4:587-94. 2005
    ..These data provide preclinical support for a combined chemotherapeutic approach with NF-kappa B inhibitors and NSAIDs for the treatment of pancreatic adenocarcinoma...
  45. pmc AKT alters genome-wide estrogen receptor alpha binding and impacts estrogen signaling in breast cancer
    Poornima Bhat-Nakshatri
    Department of Surgery, Indiana University School of Medicine, 1044 West Walnut St, Indianapolis, IN 46202, USA
    Mol Cell Biol 28:7487-503. 2008
    ....
  46. ncbi request reprint Inhibiting proteasomal proteolysis sustains estrogen receptor-alpha activation
    Meiyun Fan
    Medical Sciences, Indiana University School of Medicine, 302 Jordan Hall, 1001 East 3rd Street, Bloomington, Indiana 47405 4401, USA
    Mol Endocrinol 18:2603-15. 2004
    ....
  47. ncbi request reprint Suppression of pancreatic tumor growth by combination chemotherapy with sulindac and LC-1 is associated with cyclin D1 inhibition in vivo
    Michele T Yip-Schneider
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Mol Cancer Ther 6:1736-44. 2007
    ..These results suggest that LC-1 and sulindac may mediate their antitumor effects, in part, by altering cyclin D1 levels. Furthermore, this study provides preclinical evidence for the therapeutic efficacy of these agents...
  48. ncbi request reprint Differential effect of anti-apoptotic genes Bcl-xL and c-FLIP on sensitivity of MCF-7 breast cancer cells to paclitaxel and docetaxel
    Zhuo Wang
    Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Anticancer Res 25:2367-79. 2005
    ..In the present study, we tested the sensitivity of MCF-7 breast cancer cells overexpressing anti-apoptotic genes TRAF-1, c-FLIP, Bcl-xL, clAP-2 or Mn-SOD to paclitaxel and docetaxel...
  49. doi request reprint Antimyeloma effects of a sesquiterpene lactone parthenolide
    Attaya Suvannasankha
    Hematology and Oncology Division, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Clin Cancer Res 14:1814-22. 2008
    ..The sesquiterpene lactone parthenolide targets NF-kappaB. However, its therapeutic potential in MM is not known...
  50. ncbi request reprint Parthenolide sensitizes cells to X-ray-induced cell killing through inhibition of NF-kappaB and split-dose repair
    Marc S Mendonca
    Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Radiat Res 168:689-97. 2007
    ..Further studies demonstrated that the enhancement of X-ray-induced cell killing by parthenolide is due to inhibition of split-dose repair...
  51. ncbi request reprint Enhanced peritoneal ovarian tumor dissemination by tissue transglutaminase
    Minati Satpathy
    Department of Medicine, Indiana University School of Medicine, 535 Barnhill Drive, RT 473, Indianapolis, IN 46202, USA
    Cancer Res 67:7194-202. 2007
    ..Highly expressed in ovarian tumors, TG2 facilitates i.p. tumor dissemination by enhancing cell adhesion to the extracellular matrix and modulating beta(1) integrin subunit expression...
  52. doi request reprint Obesity potentiates the growth and dissemination of pancreatic cancer
    Nicholas J Zyromski
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Surgery 146:258-63. 2009
    ..The aim of the current study was to investigate the influence of obesity on pancreatic cancer growth using a novel in vivo model...
  53. ncbi request reprint Binding and activation of the human aldehyde dehydrogenase 2 promoter by hepatocyte nuclear factor 4
    M J Stewart
    Department of Medicine, Indiana University School of Medicine, Indianapolis 46202 5121, USA
    Biochim Biophys Acta 1399:181-6. 1998
    ..These results suggest that the tissue specificity of ALDH2 expression is in part determined by its activation by HNF-4...
  54. doi request reprint Expression of Forkhead-box protein A1, a marker of luminal A type breast cancer, parallels low Oncotype DX 21-gene recurrence scores
    Foluso O Ademuyiwa
    Department of Medicine, Indiana University, School of Medicine, Indianapolis, IN 46202, USA
    Mod Pathol 23:270-5. 2010
    ..To confirm these findings, further studies in a larger cohort of patients are warranted...
  55. pmc Estradiol-regulated microRNAs control estradiol response in breast cancer cells
    Poornima Bhat-Nakshatri
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
    Nucleic Acids Res 37:4850-61. 2009
    ..Additionally, our studies reveal a negative-regulatory loop controlling E2 response through microRNAs as well as differences in E2-induced transcriptome and proteome...
  56. doi request reprint Striatin-3 gamma inhibits estrogen receptor activity by recruiting a protein phosphatase
    Bailin Tan
    Department of Obstetrics and Gynecology University School of Medicine, Indianapolis, Indiana 46202, USA
    J Mol Endocrinol 40:199-210. 2008
    ..These observations suggest that an rSTRN3gamma-PP2A(C) complex is recruited to agonist-activated ERalpha, thereby leading to its dephosphorylation and inhibiting transcription...
  57. ncbi request reprint The platelet-activating factor receptor protects epidermal cells from tumor necrosis factor (TNF) alpha and TNF-related apoptosis-inducing ligand-induced apoptosis through an NF-kappa B-dependent process
    M D Southall
    Department of Dermatology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 276:45548-54. 2001
    ..These studies provide a mechanism whereby the epidermal PAF-R, and possibly other G protein-coupled receptors, can exert anti-apoptotic effects through an NF-kappa B-dependent process...
  58. ncbi request reprint Effect of celecoxib and novel agent LC-1 in a hamster model of lung cancer
    Reid C Vegeler
    Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Surg Res 143:169-76. 2007
    ..The therapeutic potential of celecoxib, a COX-2 selective inhibitor, and LC-1, a pro-apoptotic drug with accompanying inhibition of NF-kappaB, were investigated...
  59. ncbi request reprint MOZ and MOZ-CBP cooperate with NF-kappaB to activate transcription from NF-kappaB-dependent promoters
    Edward M Chan
    Walther Oncology Center, Indianapolis, IN, USA
    Exp Hematol 35:1782-92. 2007
    ....
  60. ncbi request reprint The macrophage inhibitory cytokine integrates AKT/PKB and MAP kinase signaling pathways in breast cancer cells
    Wyatt Wollmann
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Carcinogenesis 26:900-7. 2005
    ..These results suggest that AKT/PKB through MIC-1 could regulate the ERK1 activity and the MIC-1 expression levels may serve as a surrogate marker for the AKT activation in tumors...
  61. ncbi request reprint Cutting edge: IL-17F, a novel cytokine selectively expressed in activated T cells and monocytes, regulates angiogenesis and endothelial cell cytokine production
    T Starnes
    Department of Medicine and Biochemistry, Walther Oncology Center, Indiana University Medical Center, Indianapolis, IN 46202, USA
    J Immunol 167:4137-40. 2001
    ..However, it markedly inhibited the angiogenesis of human endothelial cells and induced endothelial cells to produce IL-2, TGF-beta, and monocyte chemoattractant protein-1...
  62. ncbi request reprint Phase I dose escalation trial of feverfew with standardized doses of parthenolide in patients with cancer
    Eardie A Curry
    Department of Pharmacy Practice, Purdue University, Indianapolis, IN, USA
    Invest New Drugs 22:299-305. 2004
    ..Feverfew has been used extensively without any formal pharmacokinetic analysis. A Phase I trial was conducted to evaluate the pharmacokinetics and toxicity of parthenolide given as a component of "feverfew."..
  63. ncbi request reprint Negative regulation of MHC class II gene expression by CXCR4
    Carol Sheridan
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Exp Hematol 34:1085-92. 2006
    ..We have initiated a study aimed at dissecting additional functions of CXCR4 in cancer cells, particularly in relation to the immune system...
  64. ncbi request reprint 2-methoxyestradiol inhibits the anaphase-promoting complex and protein translation in human breast cancer cells
    Rajendra Bhati
    Lineberger Comprehensive Cancer Center, Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Cancer Res 67:702-8. 2007
    ..2ME2 induces tubulin-dependent cell cycle arrest through regulation of genes involved in the mitotic spindle assembly checkpoint, which results in inhibition of the APC and tubulin-independent inhibition of protein translation...
  65. ncbi request reprint Phosphoinositol phosphatase SHIP2 promotes cancer development and metastasis coupled with alterations in EGF receptor turnover
    Nagendra K Prasad
    Department of Basic Medical Sciences and Purdue Cancer Center, Purdue University, Lynn Hall, 625 Harrison Street, West Lafayette, IN 47907, USA
    Carcinogenesis 29:25-34. 2008
    ..Taken together, our results demonstrate that SHIP2 is a clinically relevant novel anticancer target that links perturbed metabolism to cancer development...
  66. ncbi request reprint Identity profiling of cell surface markers by multiplex gold nanorod probes
    Chenxu Yu
    Department of Agricultural and Biological Engineering and Bindley Biosciences Center, Purdue University, 225 South University Drive, West Lafayette, Indiana 47906, USA
    Nano Lett 7:2300-6. 2007
    ..The technique has the potential to become an important tool for diagnosis and prognosis of breast and other cancers...

Research Grants9

  1. Chemoprevention Through Activation of Estrogen Receptor Alpha-Induced Senescence
    Harikrishna Nakshatri; Fiscal Year: 2007
    ..Our long- term goal is to identify molecular targets for senescence-based chemoprevention strategies for ERa-positive breast cancers. ..
  2. AKT MEDIATED TAMOXIFEN RESISTANCE IN BREAST CANCER CELLS
    Harikrishna Nakshatri; Fiscal Year: 2005
    ..3) By inactivating PTEN, through a dominant-negative mutant or antisense RNA, we will determine whether loss of PTEN leads to increased ERalpha activity and tamoxifen-resistant growth of breast cancer cells. ..
  3. Animal Model for Local Inflammation-Induced Breast Cancer
    Harikrishna Nakshatri; Fiscal Year: 2007
    ..We propose that we will not completely eliminate but control NF-?B activity (similar to the approach with beta-blockers for cardiovascular diseases) so that normal activity of immune system is not compromised with LC-1 treatment. ..