Research Topics
Genomes and Genes | H NakshatriSummaryAffiliation: Indiana University Country: USA Publications
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Publications
NF-kappaB promotes breast cancer cell migration and metastasis by inducing the expression of the chemokine receptor CXCR4Gregory Helbig
Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
J Biol Chem 278:21631-8. 2003..Taken together, these results implicate NF-kappaB in the migration and the organ-specific homing of metastatic breast cancer cells...
Epithelial-to-mesenchymal transition and ovarian tumor progression induced by tissue transglutaminaseMinghai Shao
Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
Cancer Res 69:9192-201. 2009..Highly expressed in ovarian tumors, TG2 promotes EMT and enhances ovarian tumor metastasis by activating oncogenic signaling...
Persistent upregulation of U6:SNORD44 small RNA ratio in the serum of breast cancer patientsHitesh N Appaiah
Department of Surgery, Indiana University School of Medicine, West Walnut Street, Indianapolis, IN 46202, USA
Breast Cancer Res 13:R86. 2011..This investigation addresses two issues that impact their utility: a) appropriate normalization controls and b) whether their altered levels persist in patients who are clinically free of the disease...- A large, consistent plasma proteomics data set from prospectively collected breast cancer patient and healthy volunteer samplesCatherine P Riley
Bindley Bioscience Center, Purdue University, West Lafayette, IN, USA
J Transl Med 9:80. 2011..Variability of plasma sample collection and of proteomics technology platforms has been detrimental to generation of large proteomic profile datasets from human biospecimens... 
CD44+/CD24- breast cancer cells exhibit enhanced invasive properties: an early step necessary for metastasisCarol Sheridan
Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Breast Cancer Res 8:R59. 2006..CONCLUSION: Breast cancer cells with CD44+/CD24- subpopulation express higher levels of proinvasive genes and have highly invasive properties. However, this phenotype is not sufficient to predict capacity for pulmonary metastasis...- SLUG/SNAI2 and tumor necrosis factor generate breast cells with CD44+/CD24- phenotypePoornima Bhat-Nakshatri
Department of Surgery, Indiana University School of Medicine, West Walnut Street, Indianapolis, IN 46202, USA
BMC Cancer 10:411. 2010..However, whether all genes that induce EMT confer the CD44+/CD24- phenotype is unknown. We hypothesized that only a subset of genes associated with EMT generates CD44+/CD24- cells... - The orphan receptor COUP-TFII regulates G2/M progression of breast cancer cells by modulating the expression/activity of p21(WAF1/CIP1), cyclin D1, and cdk2H Nakshatri
Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Biochem Biophys Res Commun 270:1144-53. 2000..Furthermore, these results reveal an important physiological function of COUP-TFII, which correlates with its ability to induce gene expression rather than modulation of nuclear receptor activity... - Breast cancer stem cells and intrinsic subtypes: controversies rage onHarikrishna Nakshatri
Department of Surgery, Indiana University School of Medicine, 1044 West Walnut Street, Indianapolis, IN 46202, USA
Curr Stem Cell Res Ther 4:50-60. 2009.... - Intrinsic subtype-associated changes in the plasma proteome in breast cancerHarikrishna Nakshatri
Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA
Proteomics Clin Appl 3:1305-13. 2009..These results reveal intrinsic subtype specific changes in the plasma proteome that may influence tumor progression as well as the systemic effects of cancer... - Antitumor agent parthenolide reverses resistance of breast cancer cells to tumor necrosis factor-related apoptosis-inducing ligand through sustained activation of c-Jun N-terminal kinaseHarikrishna Nakshatri
Department of Surgery, Indiana University School of Medicine, Indianapolis 46202, USA
Oncogene 23:7330-44. 2004..These results identify a new antitumor activity of parthenolide, which can be exploited to reverse resistance of cancer cells to TRAIL, particularly those with elevated XIAP levels... - FOXA1 in breast cancerHarikrishna Nakshatri
Departments of Surgery, Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Expert Rev Mol Med 11:e8. 2009..Additionally, we discuss modulators of FOXA1 function, ERalpha-FOXA1-GATA3 downstream targets, and potential therapeutic agents that may increase differentiation through FOXA1... - Multiple parameters determine the specificity of transcriptional response by nuclear receptors HNF-4, ARP-1, PPAR, RAR and RXR through common response elementsH Nakshatri
Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Nucleic Acids Res 26:2491-9. 1998.... - FOXA1 as a therapeutic target for breast cancerHarikrishna Nakshatri
Indiana University School of Medicine, Departments of Surgery, Biochemistry and Molecular Biology, Walther Oncology Center, Indianapolis, IN 46202, USA
Expert Opin Ther Targets 11:507-14. 2007..This article reviews possible roles of FOXA family transcription factors in breast cancer initiation, hormone dependency and speculates on the potential of FOXA1 as a therapeutic target... - Tumour necrosis factor and PI3-kinase control oestrogen receptor alpha protein level and its transrepression functionP Bhat Nakshatri
Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Br J Cancer 90:853-9. 2004..From these results, we propose that TNFalpha expression or PI3-kinase activation lead to reduced levels of ERalpha protein in cancer cells and corresponding loss of transrepression function and acquisition of an invasive phenotype... - Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistanceR A Campbell
Department of Surgery, Indiana University School of Medicine, Indianapolis 46202, USA
J Biol Chem 276:9817-24. 2001..Taken together, these results define a molecular link between activation of the PI 3-kinase/AKT survival pathways, hormone-independent activation of ERalpha, and inhibition of tamoxifen-induced apoptotic regression... - Constitutive activation of NF-kappaB during progression of breast cancer to hormone-independent growthH Nakshatri
Department of Surgery, Indiana University School of Medicine, Indianapolis 46202, USA
Mol Cell Biol 17:3629-39. 1997.... - Transformation of interleukin-3-dependent cells without participation of Stat5/bcl-xL: cooperation of akt with raf/erk leads to p65 nuclear factor kappaB-mediated antiapoptosis involving c-IAP2V M Gelfanov
Walther Cancer Institute and Division of Hematology/Oncology, Department of Medicine, Indiana University School of Medicine and VA Medical Center, Indianapolis, IN 46202, USA
Blood 98:2508-17. 2001.... - NF-kappaB represses E-cadherin expression and enhances epithelial to mesenchymal transition of mammary epithelial cells: potential involvement of ZEB-1 and ZEB-2H L Chua
Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
Oncogene 26:711-24. 2007..MCF10A cells chronically exposed to tumor necrosis factor alpha (TNFalpha), a potent NF-kappaB inducer, also exhibited the EMT-like phenotype and ZEB-1/ZEB-2 induction, both of which were reversed following TNFalpha withdrawal... - Repression of GADD153/CHOP by NF-kappaB: a possible cellular defense against endoplasmic reticulum stress-induced cell deathS Nozaki
Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Oncogene 20:2178-85. 2001..These results establish a correlation between repression of pro-apoptotic genes by NF-kappaB and increased cell survival during ER stress as well as identify a distinct NF-kappaB regulated cell survival pathway... - The sesquiterpene lactone parthenolide in combination with docetaxel reduces metastasis and improves survival in a xenograft model of breast cancerChristopher J Sweeney
Department of Medicine, Indiana University School of Medicine, Indianapolis, USA
Mol Cancer Ther 4:1004-12. 2005..These results for the first time reveal the significant in vivo chemosensitizing properties of parthenolide in the metastatic breast cancer setting and support the contention that metastases are very reliant on activation of NF-kappaB... - Forkhead box A1 expression in breast cancer is associated with luminal subtype and good prognosisM A Thorat
Department of Pathology and Laboratory Medicine, IU School of Medicine, Indianapolis, IN 46202, USA
J Clin Pathol 61:327-32. 2008..This study explored the FOXA1 relationship with luminal and basal breast cancer subtypes, proliferation markers, and survival in breast cancer patients who had received similar treatment... - Restoring chemotherapy and hormone therapy sensitivity by parthenolide in a xenograft hormone refractory prostate cancer modelRajasubramaniam Shanmugam
Department of Medicine, Indiana University, Indianapolis, Indiana, USA
Prostate 66:1498-511. 2006..CONCLUSION: These studies demonstrate parthenolide's anti-tumor and anti-angiogenic activity, and its potential to augment the efficacy of chemotherapy and hormonal therapy... - Prognosis of hormone-dependent breast cancers: implications of the presence of dysfunctional transcriptional networks activated by insulin via the immune transcription factor T-betKasi McCune
Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Cancer Res 70:685-96. 2010.... - The p160 family coactivators regulate breast cancer cell proliferation and invasion through autocrine/paracrine activity of SDF-1alpha/CXCL12Hiromitsu Kishimoto
Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Carcinogenesis 26:1706-15. 2005..These results also provide a molecular explanation for recent observations linking co-overexpression of coactivators and her2/neu with poor prognosis: coactivators increase SDF-1alpha expression whereas her2/neu stabilize CXCR4 protein... - Control of EVI-1 oncogene expression in metastatic breast cancer cells through microRNA miR-22J B Patel
Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
Oncogene 30:1290-301. 2011..Identifying such metastasis-specific oncogenic pathways may help to manipulate tumor behavior and aid in the design of more effective targeted therapies... - Fusion AML1 transcript in a radiation-associated leukemia results in a truncated inhibitory AML1 proteinR Hromas
Indiana University Cancer Center, Indianapolis, Indiana 46202, USA
Blood 97:2168-70. 2001..This fusion AML1 protein functions as an inhibitor of the normal AML1 protein. (Blood. 2001;97:2168-2170).. - Oestrogen-receptor-positive breast cancer: towards bridging histopathological and molecular classificationsS Badve
Department of Pathology and Laboratory Medicine, and Internal Medicine, Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN, USA
J Clin Pathol 62:6-12. 2009..A detailed understanding of these areas will permit better classification and a personalised approach to management of ER-positive breast cancers... - Negative regulation of chemokine receptor CXCR4 by tumor suppressor p53 in breast cancer cells: implications of p53 mutation or isoform expression on breast cancer cell invasionS A Mehta
Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Oncogene 26:3329-37. 2007..We propose that p53 rescue drugs either alone or in combination with chemotherapeutic drugs may be effective in reducing CXCR4-mediated metastasis... - Effects of HIV protease inhibitor ritonavir on Akt-regulated cell proliferation in breast cancerAnjaiah Srirangam
Department of Medicine, Indiana University, Indianapolis, Indiana 46202, USA
Clin Cancer Res 12:1883-96. 2006..Ritonavir may be of interest for breast cancer therapeutics and its efficacy may be increased by sustained exposure or Hsp90 RNA interference... - Tissue transglutaminase protects epithelial ovarian cancer cells from cisplatin-induced apoptosis by promoting cell survival signalingLiyun Cao
Department of Medicine, Richard L Roudebush Veterans Affairs Medical Center, Indiana University School of Medicine, 535 Barnhill Drive, RT 473, Indianapolis, IN 46202, USA
Carcinogenesis 29:1893-900. 2008..Our data show that TG2 prevents apoptosis induced by cisplatin by activating the NF-kappaB survival pathway in ovarian cancer cells... - Identification of signal transduction pathways involved in constitutive NF-kappaB activation in breast cancer cellsPoornima Bhat-Nakshatri
Walther Oncology Center, Indiana University School of Medicine, Indianapolis, Indiana, IN 46202, USA
Oncogene 21:2066-78. 2002.... - FOXA1 expression in breast cancer--correlation with luminal subtype A and survivalSunil Badve
Department of Pathology, Indiana University School of Medicine, Indianapolis, USA
Clin Cancer Res 13:4415-21. 2007..It segregates with genes that characterize the luminal subtypes in DNA microarray analyses. The utility of FOXA1 as a possible independent prognostic factor has not been determined in breast cancers... - Amplified in breast cancer 1 expression in breast cancerM A Thorat
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Histopathology 53:634-41. 2008..The aim was to analyse AIB1 expression by immunohistochemistry and study its correlations with other prognostic variables in breast cancer and its effect on survival... - NF-kappaB inhibition in human hepatocellular carcinoma and its potential as adjunct to sorafenib based therapyJian Min Wu
Department of Surgery, Indiana University School of Medicine, 1001 W 10th Street, Indianapolis, IN 46202, USA
Cancer Lett 278:145-55. 2009.... - Interleukin-1 alpha promotes tumor growth and cachexia in MCF-7 xenograft model of breast cancerSuresh Kumar
Departments of Surgery, Indiana University School of Medicine, Indianapolis 46202, USA
Am J Pathol 163:2531-41. 2003..Taken together, these results suggest that cancer cell-derived cytokines, such as IL-1 alpha, induce cachexia by affecting leptin-dependent metabolic pathways... - A water-soluble parthenolide analogue suppresses in vivo prostate cancer growth by targeting NFkappaB and generating reactive oxygen speciesRajasubramaniam Shanmugam
Department of Medicine, Indiana University, Indianapolis, Indiana, USA
Prostate 70:1074-86. 2010..To characterize the molecular changes associated with DMAPT-induced prostate cancer cell death and its in vivo activity... - Cloning of BRAK, a novel divergent CXC chemokine preferentially expressed in normal versus malignant cellsR Hromas
Department of Hematology and Oncology, Walther Oncology Center, Indiana University Medical Center, R4 202, 1044 W Walnut Street, Indianapolis, Indiana, 46202
Biochem Biophys Res Commun 255:703-6. 1999..BRAK is expressed ubiquitously and highly in normal tissue. However, it was expressed in only 2 of 18 cancer cell lines. BRAK is located on human chromosome 5q31... - NF-kappaB and breast cancerHarikrishna Nakshatri
Indiana University School of Medicine, Walther Cancer Institute, Indianapolis, USA
Curr Probl Cancer 26:282-309. 2002 - Inhibiting proteasomal proteolysis sustains estrogen receptor-alpha activationMeiyun Fan
Medical Sciences, Indiana University School of Medicine, 302 Jordan Hall, 1001 East 3rd Street, Bloomington, Indiana 47405-4401, USA
Mol Endocrinol 18:2603-15. 2004.... - Nuclear factor-kappaB is constitutively activated in prostate cancer in vitro and is overexpressed in prostatic intraepithelial neoplasia and adenocarcinoma of the prostateChristopher Sweeney
Department of Medicine, Indiana University, Indianapolis, Indiana 46202, USA
Clin Cancer Res 10:5501-7. 2004..The transcription factor nuclear factor-kappaB (NF-kappaB) promotes the production of angiogenic, antiapoptotic, and prometastatic factors that are involved in carcinogenesis... - Differential effect of anti-apoptotic genes Bcl-xL and c-FLIP on sensitivity of MCF-7 breast cancer cells to paclitaxel and docetaxelZhuo Wang
Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Anticancer Res 25:2367-79. 2005.... - Antimyeloma effects of a sesquiterpene lactone parthenolideAttaya Suvannasankha
Hematology and Oncology Division, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Clin Cancer Res 14:1814-22. 2008..The sesquiterpene lactone parthenolide targets NF-kappaB. However, its therapeutic potential in MM is not known... - Parthenolide sensitizes cells to X-ray-induced cell killing through inhibition of NF-kappaB and split-dose repairMarc S Mendonca
Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Radiat Res 168:689-97. 2007..Further studies demonstrated that the enhancement of X-ray-induced cell killing by parthenolide is due to inhibition of split-dose repair... - AKT alters genome-wide estrogen receptor alpha binding and impacts estrogen signaling in breast cancerPoornima Bhat-Nakshatri
Department of Surgery, Indiana University School of Medicine, 1044 West Walnut St, Indianapolis, IN 46202, USA
Mol Cell Biol 28:7487-503. 2008.... - Parthenolide and sulindac cooperate to mediate growth suppression and inhibit the nuclear factor-kappa B pathway in pancreatic carcinoma cellsMichele T Yip-Schneider
Department of Surgery, Indiana University School of Medicine, Room 041, Building R4, 1044 West Walnut Street, Indianapolis, IN 46202, USA
Mol Cancer Ther 4:587-94. 2005..These data provide preclinical support for a combined chemotherapeutic approach with NF-kappa B inhibitors and NSAIDs for the treatment of pancreatic adenocarcinoma... - Suppression of pancreatic tumor growth by combination chemotherapy with sulindac and LC-1 is associated with cyclin D1 inhibition in vivoMichele T Yip-Schneider
Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Mol Cancer Ther 6:1736-44. 2007..These results suggest that LC-1 and sulindac may mediate their antitumor effects, in part, by altering cyclin D1 levels. Furthermore, this study provides preclinical evidence for the therapeutic efficacy of these agents... - Subcellular localization of activated AKT in estrogen receptor- and progesterone receptor-expressing breast cancers: potential clinical implicationsSunil Badve
Department of Pathology and Internal Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Am J Pathol 176:2139-49. 2010..These results suggest that subcellular localization of activated AKT plays a significant role in determining its function in breast cancer, which in part is dependent on TCL1B expression... - The platelet-derived growth factor receptor alpha is destabilized by geldanamycins in cancer cellsDaniela Matei
Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
J Biol Chem 282:445-53. 2007..These results show that 17-AAG promotes PDGFRalpha degradation selectively in transformed cells. Thus, not only mutated tyrosine kinases but also overexpressed receptors in cancer cells can be targeted by 17-AAG... - Enhanced peritoneal ovarian tumor dissemination by tissue transglutaminaseMinati Satpathy
Department of Medicine, Indiana University School of Medicine, 535 Barnhill Drive, RT 473, Indianapolis, IN 46202, USA
Cancer Res 67:7194-202. 2007..Highly expressed in ovarian tumors, TG2 facilitates i.p. tumor dissemination by enhancing cell adhesion to the extracellular matrix and modulating beta(1) integrin subunit expression... - Obesity potentiates the growth and dissemination of pancreatic cancerNicholas J Zyromski
Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Surgery 146:258-63. 2009..The aim of the current study was to investigate the influence of obesity on pancreatic cancer growth using a novel in vivo model... - Binding and activation of the human aldehyde dehydrogenase 2 promoter by hepatocyte nuclear factor 4M J Stewart
Department of Medicine, Indiana University School of Medicine, Indianapolis 46202 5121, USA
Biochim Biophys Acta 1399:181-6. 1998..These results suggest that the tissue specificity of ALDH2 expression is in part determined by its activation by HNF-4... - Expression of Forkhead-box protein A1, a marker of luminal A type breast cancer, parallels low Oncotype DX 21-gene recurrence scoresFoluso O Ademuyiwa
Department of Medicine, Indiana University, School of Medicine, Indianapolis, IN 46202, USA
Mod Pathol 23:270-5. 2010..To confirm these findings, further studies in a larger cohort of patients are warranted... - Striatin-3 gamma inhibits estrogen receptor activity by recruiting a protein phosphataseBailin Tan
Department of Obstetrics and Gynecology University School of Medicine, Indianapolis, Indiana 46202, USA
J Mol Endocrinol 40:199-210. 2008..These observations suggest that an rSTRN3gamma-PP2A(C) complex is recruited to agonist-activated ERalpha, thereby leading to its dephosphorylation and inhibiting transcription... - Estradiol-regulated microRNAs control estradiol response in breast cancer cellsPoornima Bhat-Nakshatri
Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
Nucleic Acids Res 37:4850-61. 2009..Additionally, our studies reveal a negative-regulatory loop controlling E2 response through microRNAs as well as differences in E2-induced transcriptome and proteome... - The platelet-activating factor receptor protects epidermal cells from tumor necrosis factor (TNF) alpha and TNF-related apoptosis-inducing ligand-induced apoptosis through an NF-kappa B-dependent processM D Southall
Department of Dermatology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
J Biol Chem 276:45548-54. 2001..These studies provide a mechanism whereby the epidermal PAF-R, and possibly other G protein-coupled receptors, can exert anti-apoptotic effects through an NF-kappa B-dependent process... - Effect of celecoxib and novel agent LC-1 in a hamster model of lung cancerReid C Vegeler
Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
J Surg Res 143:169-76. 2007..The therapeutic potential of celecoxib, a COX-2 selective inhibitor, and LC-1, a pro-apoptotic drug with accompanying inhibition of NF-kappaB, were investigated... - MOZ and MOZ-CBP cooperate with NF-kappaB to activate transcription from NF-kappaB-dependent promotersEdward M Chan
Walther Oncology Center, Indianapolis, IN, USA
Exp Hematol 35:1782-92. 2007.... - The macrophage inhibitory cytokine integrates AKT/PKB and MAP kinase signaling pathways in breast cancer cellsWyatt Wollmann
Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Carcinogenesis 26:900-7. 2005..These results suggest that AKT/PKB through MIC-1 could regulate the ERK1 activity and the MIC-1 expression levels may serve as a surrogate marker for the AKT activation in tumors... - Cutting edge: IL-17F, a novel cytokine selectively expressed in activated T cells and monocytes, regulates angiogenesis and endothelial cell cytokine productionT Starnes
Department of Medicine and Biochemistry, Walther Oncology Center, Indiana University Medical Center, Indianapolis, IN 46202, USA
J Immunol 167:4137-40. 2001..However, it markedly inhibited the angiogenesis of human endothelial cells and induced endothelial cells to produce IL-2, TGF-beta, and monocyte chemoattractant protein-1... - Negative regulation of MHC class II gene expression by CXCR4Carol Sheridan
Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Exp Hematol 34:1085-92. 2006..We have initiated a study aimed at dissecting additional functions of CXCR4 in cancer cells, particularly in relation to the immune system... - Phase I dose escalation trial of feverfew with standardized doses of parthenolide in patients with cancerEardie A Curry
Department of Pharmacy Practice, Purdue University, Indianapolis, IN, USA
Invest New Drugs 22:299-305. 2004..Purification of parthenolide for administration of higher doses will be needed... - Phosphoinositol phosphatase SHIP2 promotes cancer development and metastasis coupled with alterations in EGF receptor turnoverNagendra K Prasad
Department of Basic Medical Sciences and Purdue Cancer Center, Purdue University, Lynn Hall, 625 Harrison Street, West Lafayette, IN 47907, USA
Carcinogenesis 29:25-34. 2008..Taken together, our results demonstrate that SHIP2 is a clinically relevant novel anticancer target that links perturbed metabolism to cancer development... - 2-methoxyestradiol inhibits the anaphase-promoting complex and protein translation in human breast cancer cellsRajendra Bhati
Lineberger Comprehensive Cancer Center, Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
Cancer Res 67:702-8. 2007..2ME2 induces tubulin-dependent cell cycle arrest through regulation of genes involved in the mitotic spindle assembly checkpoint, which results in inhibition of the APC and tubulin-independent inhibition of protein translation... - Identity profiling of cell surface markers by multiplex gold nanorod probesChenxu Yu
Department of Agricultural and Biological Engineering and Bindley Biosciences Center, Purdue University, 225 South University Drive, West Lafayette, Indiana 47906, USA
Nano Lett 7:2300-6. 2007..The technique has the potential to become an important tool for diagnosis and prognosis of breast and other cancers...
Research Grants
- Chemoprevention Through Activation of Estrogen Receptor Alpha-Induced SenescenceHarikrishna Nakshatri; Fiscal Year: 2007..Our long- term goal is to identify molecular targets for senescence-based chemoprevention strategies for ERa-positive breast cancers. ..
- AKT MEDIATED TAMOXIFEN RESISTANCE IN BREAST CANCER CELLSHarikrishna Nakshatri; Fiscal Year: 2005..3) By inactivating PTEN, through a dominant-negative mutant or antisense RNA, we will determine whether loss of PTEN leads to increased ERalpha activity and tamoxifen-resistant growth of breast cancer cells. ..
- Animal Model for Local Inflammation-Induced Breast CancerHarikrishna Nakshatri; Fiscal Year: 2007..We propose that we will not completely eliminate but control NF-?B activity (similar to the approach with beta-blockers for cardiovascular diseases) so that normal activity of immune system is not compromised with LC-1 treatment. ..