Bruce Molitoris

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. pmc Multiple factors influence glomerular albumin permeability in rats
    Ruben M Sandoval
    Division of Nephrology, Department of Medicine, Indiana Center for Biological Microscopy, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Am Soc Nephrol 23:447-57. 2012
  2. doi request reprint Technology Insight: biomarker development in acute kidney injury--what can we anticipate?
    Bruce A Molitoris
    Division of Nephrology, Department of Medicine and the Indiana Center for Biologic Microscopy, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Nat Clin Pract Nephrol 4:154-65. 2008
  3. ncbi request reprint Endothelial injury and dysfunction: role in the extension phase of acute renal failure
    Bruce A Molitoris
    Division of Nephrology, Department of Medicine, and the Indiana Center for Biological Microscopy, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Kidney Int 66:496-9. 2004
  4. ncbi request reprint Actin cytoskeleton in ischemic acute renal failure
    Bruce A Molitoris
    Indiana University School of Medicine, Nephrology Division, Indianapolis, Indiana 46202, USA
    Kidney Int 66:871-83. 2004
  5. ncbi request reprint Intravital multiphoton microscopy of dynamic renal processes
    Bruce A Molitoris
    Div of Nephrology, Indiana Univ School of Medicine, 950 W Walnut St, R2 202C, Indianapolis, IN 46202, USA
    Am J Physiol Renal Physiol 288:F1084-9. 2005
  6. pmc Renal blood flow in sepsis: a complex issue
    Bruce A Molitoris
    Division of Nephrology, Department of Medicine and the Indiana Center for Biological Microscopy, Indiana University School of Medicine, Indianapolis, IN, USA
    Crit Care 9:327-8. 2005
  7. ncbi request reprint Improving outcomes of acute kidney injury: report of an initiative
    Bruce A Molitoris
    Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Nat Clin Pract Nephrol 3:439-42. 2007
  8. doi request reprint Multiphoton imaging techniques in acute kidney injury
    Bruce A Molitoris
    Division of Nephrology, Department of Medicine, Indiana Center for Biological Microscopy, Indiana University School of Medicine, Indianapolis, Ind 46202, USA
    Contrib Nephrol 165:46-53. 2010
  9. pmc siRNA targeted to p53 attenuates ischemic and cisplatin-induced acute kidney injury
    Bruce A Molitoris
    Department of Medicine, Division of Nephrology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Am Soc Nephrol 20:1754-64. 2009
  10. doi request reprint Techniques to study nephron function: microscopy and imaging
    Bruce A Molitoris
    Department of Medicine, Indiana University School of Medicine, Indianapolis, 46202, USA
    Pflugers Arch 458:203-9. 2009

Research Grants

  1. RAB5 AND PI-3-KINASE AND GENTAMICIN TOXICITY
    Bruce Molitoris; Fiscal Year: 2002
  2. Center for Advanced Renal Microscopic Analysis
    Bruce Molitoris; Fiscal Year: 2006
  3. Ischemia-induced Actin Cytoskeletal Alterations
    Bruce Molitoris; Fiscal Year: 2007
  4. Center for Advanced Renal Microscopic Analysis
    Bruce Molitoris; Fiscal Year: 2007

Collaborators

Detail Information

Publications58

  1. pmc Multiple factors influence glomerular albumin permeability in rats
    Ruben M Sandoval
    Division of Nephrology, Department of Medicine, Indiana Center for Biological Microscopy, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Am Soc Nephrol 23:447-57. 2012
    ..In summary, these results help explain the previously conflicting microscopy and micropuncture data describing albumin filtration and highlight the dynamic nature of glomerular albumin permeability...
  2. doi request reprint Technology Insight: biomarker development in acute kidney injury--what can we anticipate?
    Bruce A Molitoris
    Division of Nephrology, Department of Medicine and the Indiana Center for Biologic Microscopy, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Nat Clin Pract Nephrol 4:154-65. 2008
    ..Great strides forward are being made in breaking down important barriers to the successful prevention and treatment of this devastating disorder...
  3. ncbi request reprint Endothelial injury and dysfunction: role in the extension phase of acute renal failure
    Bruce A Molitoris
    Division of Nephrology, Department of Medicine, and the Indiana Center for Biological Microscopy, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Kidney Int 66:496-9. 2004
    ..New diagnostic and therapeutic approaches to ischemic ARF must incorporate these finding to devise early recognition strategies and therapeutic approaches...
  4. ncbi request reprint Actin cytoskeleton in ischemic acute renal failure
    Bruce A Molitoris
    Indiana University School of Medicine, Nephrology Division, Indianapolis, Indiana 46202, USA
    Kidney Int 66:871-83. 2004
  5. ncbi request reprint Intravital multiphoton microscopy of dynamic renal processes
    Bruce A Molitoris
    Div of Nephrology, Indiana Univ School of Medicine, 950 W Walnut St, R2 202C, Indianapolis, IN 46202, USA
    Am J Physiol Renal Physiol 288:F1084-9. 2005
    ..We attempt to show how visual data can be quantified, thus allowing enhanced understanding of the process under study. Finally, emphasis is given to the possible future opportunities of this technology and its present limitations...
  6. pmc Renal blood flow in sepsis: a complex issue
    Bruce A Molitoris
    Division of Nephrology, Department of Medicine and the Indiana Center for Biological Microscopy, Indiana University School of Medicine, Indianapolis, IN, USA
    Crit Care 9:327-8. 2005
    ..Therefore, measuring total renal blood flow may not permit an adequate understanding of the role of altered hemodynamics in septic patients who develop acute renal failure...
  7. ncbi request reprint Improving outcomes of acute kidney injury: report of an initiative
    Bruce A Molitoris
    Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Nat Clin Pract Nephrol 3:439-42. 2007
    ..These proposed standards will need to be validated in future studies, a process that will be facilitated by the Acute Kidney Injury Network, which offers a forum that encourages acquisition of knowledge to improve patient outcomes...
  8. doi request reprint Multiphoton imaging techniques in acute kidney injury
    Bruce A Molitoris
    Division of Nephrology, Department of Medicine, Indiana Center for Biological Microscopy, Indiana University School of Medicine, Indianapolis, Ind 46202, USA
    Contrib Nephrol 165:46-53. 2010
    ..Its use in acute kidney injury is in its infancy but offers much promise for unraveling the complex interdependent processes known to contribute to cell injury and organ failure...
  9. pmc siRNA targeted to p53 attenuates ischemic and cisplatin-induced acute kidney injury
    Bruce A Molitoris
    Department of Medicine, Division of Nephrology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Am Soc Nephrol 20:1754-64. 2009
    ..Targeting siRNA to p53 leads to a dose-dependent attenuation of apoptotic signaling, suggesting potential therapeutic benefit for ischemic and nephrotoxic kidney injury...
  10. doi request reprint Techniques to study nephron function: microscopy and imaging
    Bruce A Molitoris
    Department of Medicine, Indiana University School of Medicine, Indianapolis, 46202, USA
    Pflugers Arch 458:203-9. 2009
    ..Its use in the kidney is in its infancy but offers much promise for unraveling the complex interdependent physiologic and pathophysiologic processes known to contribute to cell function and disease...
  11. ncbi request reprint Quantifying dynamic kidney processes utilizing multi-photon microscopy
    Bruce A Molitoris
    Department of Medicine, Division of Nephrology, Indiana University School of Medicine, and Indiana Center for Biological Microscopy, Indianapolis, IN 46202, USA
    Contrib Nephrol 156:227-35. 2007
    ..Therefore, this approach compliments existing molecular, biochemical, and pharmacologic techniques by advancing data analysis and interpretation to subcellular levels for molecules without the requirement for fixation...
  12. doi request reprint Kidney endothelial dysfunction: ischemia, localized infections and sepsis
    Bruce A Molitoris
    Indiana University Department of Medicine and the Indiana Center for Biological Microscopy, Indianapolis, IN, USA
    Contrib Nephrol 174:108-18. 2011
    ..Glomerular endothelial dysfunction may lead to preglomerular shunting of blood flow allowing kidney blood flow to remain close to normal while resulting in a reduction in glomerular filtration rate...
  13. ncbi request reprint Gentamicin traffics retrograde through the secretory pathway and is released in the cytosol via the endoplasmic reticulum
    Ruben M Sandoval
    Indiana Univ School of Medicine, 950 West Walnut, R2 E251, Indianapolis, IN 46202, USA
    Am J Physiol Renal Physiol 286:F617-24. 2004
    ....
  14. ncbi request reprint Endothelial injury and dysfunction in ischemic acute renal failure
    Bruce A Molitoris
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Crit Care Med 30:S235-40. 2002
    ..Intravital studies using multiphoton imaging techniques can now be conducted to identify and quantify endothelial cell injury and dysfunction in functioning organs...
  15. ncbi request reprint A novel method to determine specificity and sensitivity of the TUNEL reaction in the quantitation of apoptosis
    K J Kelly
    Department of Medicine, Division of Nephrology, Indiana Center for Biological Microscopy, Indiana University, Indianapolis, Indiana 46202, USA
    Am J Physiol Cell Physiol 284:C1309-18. 2003
    ..This novel and simple method will permit the determination of indices of sensitivity and specificity for the TUNEL assay in other tissues and experimental conditions...
  16. pmc Rapid diagnosis and quantification of acute kidney injury using fluorescent ratio-metric determination of glomerular filtration rate in the rat
    Exing Wang
    Nephrology Div, Dept of Medicine, Indiana Univ School of Medicine, Indianapolis, IN 46202, USA
    Am J Physiol Renal Physiol 299:F1048-55. 2010
    ....
  17. ncbi request reprint ADF/cofilin mediates actin cytoskeletal alterations in LLC-PK cells during ATP depletion
    Sharon L Ashworth
    Division of Nephrology, Department of Medicine, Indiana University, and Roudebush Veterans Affairs Medical Center, Indianapolis, Indiana 46202 5116, USA
    Am J Physiol Renal Physiol 284:F852-62. 2003
    ..These data demonstrate XAC(wt)-GFP participates in ischemia-induced actin cytoskeletal alterations and determines the rate and extent of these ATP depletion-induced cellular alterations...
  18. ncbi request reprint Nucleotide depletion increases trafficking of gentamicin to the Golgi complex in LLC-PK1 cells
    Ruben M Sandoval
    Department of Medicine, Division of Nephrology, Indiana University School of Medicine and Roudebush Veterans Administration Medical Center, Indianapolis, Indiana 46202, USA
    Am J Physiol Renal Physiol 283:F1422-9. 2002
    ..The Golgi complex must then endure the effects of gentamicin accumulated in larger quantities in an aberrant physiological state...
  19. pmc Evaluation and initial management of acute kidney injury
    Jonathan Himmelfarb
    Division of Nephrology, Maine Medical Center, 22 Bramhall Street, Portland, ME 04102, USA
    Clin J Am Soc Nephrol 3:962-7. 2008
    ....
  20. ncbi request reprint Newly developed techniques to study and diagnose acute renal failure
    Pierre C Dagher
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    J Am Soc Nephrol 14:2188-98. 2003
    ..Further development and utilization of these techniques, especially in concert with genetic, proteomic, and molecular approaches, will allow for needed insights into the pathophysiology and therapy in human ARF...
  21. ncbi request reprint Uptake and trafficking of fluorescent conjugates of folic acid in intact kidney determined using intravital two-photon microscopy
    Ruben M Sandoval
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, 950 W Walnut Street, R2 Bldg E202 C, Indianapolis, IN 46202, USA
    Am J Physiol Cell Physiol 287:C517-26. 2004
    ..Together, these data support the argument that folate conjugates (and, by extrapolation, physiological folate) bind to the apical surface of proximal tubule cells and are transported into and across the cells in endocytic compartments...
  22. doi request reprint Quantifying endocytosis in vivo using intravital two-photon microscopy
    Ruben M Sandoval
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Methods Mol Biol 440:389-402. 2008
    ..However, its use in preclinical animal models offers new insight into physiologic processes and the pathophysiology and treatment of disease processes...
  23. ncbi request reprint Rapid determination of renal filtration function using an optical ratiometric imaging approach
    Weiming Yu
    Indiana University School of Medicine, Department of Medicine, Nephrology Division, Indianapolis, IN 46202, USA
    Am J Physiol Renal Physiol 292:F1873-80. 2007
    ..This approach also offers a high sensitivity for determining plasma clearance rate of a fluorescent compound. This feature is important for rapidly quantifying small differences in plasma clearance when kidney function is changing...
  24. ncbi request reprint Microvascular endothelial injury and dysfunction during ischemic acute renal failure
    Timothy A Sutton
    Division of Nephrology, Department of Medicine, and the Indiana Center for Biological Microscopy, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Kidney Int 62:1539-49. 2002
    ..This knowledge should provide new diagnostic and therapeutic approaches to ischemic ARF...
  25. ncbi request reprint Functional studies of the kidney of living animals using multicolor two-photon microscopy
    Kenneth W Dunn
    Department of Medicine, Division of Nephrology, Indiana Center for Biological Microscopy, Indiana University Medical Center, Indianapolis 46202, USA
    Am J Physiol Cell Physiol 283:C905-16. 2002
    ....
  26. ncbi request reprint Mechanism of actin polymerization in cellular ATP depletion
    Simon J Atkinson
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 279:5194-9. 2004
    ..This mechanism provides a biochemical basis for the accumulation of F-actin aggregates in ischemic cells...
  27. ncbi request reprint Urinary actin, interleukin-6, and interleukin-8 may predict sustained ARF after ischemic injury in renal allografts
    Osun Kwon
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Am J Kidney Dis 41:1074-87. 2003
    ..Cellular damage and inflammation after ischemia contribute to sustained acute renal failure (ARF)...
  28. ncbi request reprint Injury of the renal microvascular endothelium alters barrier function after ischemia
    Timothy A Sutton
    Division of Nephrology, Department of Medicine, Indiana Center for Biological Microscopy, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Am J Physiol Renal Physiol 285:F191-8. 2003
    ..Taken together, these findings indicate that renal vascular endothelial injury occurs in ischemic ARF and may play an important role in the pathophysiology of ischemic ARF...
  29. pmc Impaired endothelial proliferation and mesenchymal transition contribute to vascular rarefaction following acute kidney injury
    David P Basile
    Department of Cellular and Integrative Physiology, Indiana Center for Biological Microscopy, Indiana University, Indianapolis, Indiana
    Am J Physiol Renal Physiol 300:F721-33. 2011
    ..Taken together, these data indicate that vascular dropout post-AKI results from endothelial phenotypic transition combined with an impaired regenerative capacity, which may contribute to progressive chronic kidney disease...
  30. ncbi request reprint Quantitative intravital microscopy using a Generalized Polarity concept for kidney studies
    Weiming Yu
    Nephrology Division, Department of Medicine, Indiana University School of Medicine, 950 W Walnut St, R2 268, Indianapolis, IN 46202, USA
    Am J Physiol Cell Physiol 289:C1197-208. 2005
    ..These results demonstrate the potential power of the GP imaging technique for quantitative studies of glomerular filtration and tubular reabsorption...
  31. ncbi request reprint Ischemia induces alterations in actin filaments in renal vascular smooth muscle cells
    Osun Kwon
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202 5113, USA
    Am J Physiol Renal Physiol 282:F1012-9. 2002
    ..We suggest that this disorganization of the actin cytoskeleton may play a contributory role in the loss of autoregulation of renal blood flow and the aberrant vascular reactivity in postischemic ARF...
  32. pmc The antibiotic gentamicin inhibits specific protein trafficking functions of the Arf1/2 family of GTPases
    Lin Lin
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Antimicrob Agents Chemother 55:246-54. 2011
    ..These results suggest that one consequence of gentamicin exposure is disruption of Arf-dependent protein trafficking...
  33. pmc Impaired tubular uptake explains albuminuria in early diabetic nephropathy
    Leileata M Russo
    Program in Membrane Biology, Division of Nephrology, Massachusetts General Hospital Harvard Medical School, Simches Research Center, Boston, MA 02114, USA
    J Am Soc Nephrol 20:489-94. 2009
    ..In conclusion, in the early stages of diabetic nephropathy, the PT plays a major role in the development of albuminuria, which may be preceded by peptideuria...
  34. pmc Soluble thrombomodulin protects ischemic kidneys
    Asif A Sharfuddin
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    J Am Soc Nephrol 20:524-34. 2009
    ..By using an sTM variant, we also determined that the protective effects of sTM were independent of its ability to generate activated protein C. These data suggest that sTM may have therapeutic potential for ischemic AKI...
  35. doi request reprint Imaging techniques in acute kidney injury
    Asif A Sharfuddin
    Division of Nephrology, Department of Medicine, Indiana Center for Biological Microscopy, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Nephron Clin Pract 109:c198-204. 2008
    ..Also, recent advances in other imaging techniques offer potential clinical diagnostic tools to study acute kidney injury in animal models and in patients...
  36. ncbi request reprint A non-nephrotoxic gentamicin congener that retains antimicrobial efficacy
    Ruben M Sandoval
    Department of Medicine, Nephrology Division, Indiana University School of Medicine, 950 W Walnut Street, R2 202C, Indianapolis, IN 46202, USA
    J Am Soc Nephrol 17:2697-705. 2006
    ..These studies have identified a component of the native gentamicin congener mixture that retains its bactericidal properties with minimal or no apparent nephrotoxicity...
  37. pmc Early monitoring of acute tubular necrosis in the rat kidney by 23Na-MRI
    Bharath K Atthe
    Department of Radiology, Indiana University Purdue University at Indianapolis, Indianapolis, Indiana 46202 5181, USA
    Am J Physiol Renal Physiol 297:F1288-98. 2009
    ..23Na-MRI has great potential for noninvasive, clinical diagnosis of evolving ATN in the setup of acute renal failure and in differentiating ATN from other causes of renal failure where tubular function is maintained...
  38. ncbi request reprint Renal ischemia induces tropomyosin dissociation-destabilizing microvilli microfilaments
    Sharon L Ashworth
    Division of Nephrology, Department of Medicine, Indiana University, Indianapolis, IN 46202 5116, USA
    Am J Physiol Renal Physiol 286:F988-96. 2004
    ....
  39. pmc Ischemic injury to kidney induces glomerular podocyte effacement and dissociation of slit diaphragm proteins Neph1 and ZO-1
    Mark C Wagner
    Department of Medicine, Division of Nephrology, Indiana University, Indianapolis, Indiana 46202, USA
    J Biol Chem 283:35579-89. 2008
    ..This study documents that renal ischemia induces dynamic changes in the molecular interactions between slit diaphragm proteins, leading to podocyte damage and proteinuria...
  40. ncbi request reprint Cofilin mediates ATP depletion-induced endothelial cell actin alterations
    Maria V Suurna
    Div of Nephrology, Indiana Univ School of Medicine, Indianapolis, IN 46202 5116, USA
    Am J Physiol Renal Physiol 290:F1398-407. 2006
    ..These results strongly support the importance of cofilin regulation in ischemia-induced endothelial cell actin cytoskeleton alterations leading to cell damage and microvascular dysfunction...
  41. ncbi request reprint Activated protein C ameliorates LPS-induced acute kidney injury and downregulates renal INOS and angiotensin 2
    Akanksha Gupta
    Division of Biotechnology Discovery Research, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285 0444, USA
    Am J Physiol Renal Physiol 293:F245-54. 2007
    ..Furthermore, the data suggest a potential therapeutic role for APC in the treatment of ARF...
  42. ncbi request reprint Intravital imaging of the kidney using multiparameter multiphoton microscopy
    Kenneth W Dunn
    Division of Nephrology, Department of Medicine, and Indiana Center for Biological Microscopy, Indianapolis, USA
    Nephron Exp Nephrol 94:e7-11. 2003
    ..Therefore, application of this technology will provide direct visualization of organ-specific and cell-specific responses to an array of stimuli and therapeutic approaches, enhancing our understanding and treatment of disease processes...
  43. pmc Cytokine-induced F-actin reorganization in endothelial cells involves RhoA activation
    Silvia B Campos
    Department of Medicine, Division of Nephrology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Am J Physiol Renal Physiol 296:F487-95. 2009
    ..These results suggest cytokines signal through the Rho-ROCK pathway, but also through another pathway to affect actin dynamics...
  44. pmc Loss of the homotypic fusion and vacuole protein sorting or golgi-associated retrograde protein vesicle tethering complexes results in gentamicin sensitivity in the yeast Saccharomyces cerevisiae
    Mark C Wagner
    Department of Medicine, Division of Nephrology, and the Indiana Center for Biological Microscopy, Indiana University School of Medicine, Indianapolis, Indiana 46202 5122, USA
    Antimicrob Agents Chemother 50:587-95. 2006
    ..The identification of genes whose absence results in gentamicin toxicity will help target specific pathways and mechanisms that contribute to gentamicin toxicity...
  45. ncbi request reprint Pharmacophotonics: utilizing multi-photon microscopy to quantify drug delivery and intracellular trafficking in the kidney
    Bruce A Molitoris
    Indiana University School of Medicine, Department of Medicine Division of Nephrology, and the Indiana Center for Biological Microscopy, Indianapolis, IN 46202, USA
    Adv Drug Deliv Rev 58:809-23. 2006
    ..Finally, up to three fluorophores can be visualized simultaneously allowing for three different or interactive processes to be observed and resolved...
  46. ncbi request reprint Micropuncture gene delivery and intravital two-photon visualization of protein expression in rat kidney
    George A Tanner
    Department of Cellular and Integrative Physiology, Indiana Univ School of Medicine, Indianapolis, IN 46202, USA
    Am J Physiol Renal Physiol 289:F638-43. 2005
    ....
  47. pmc Adenoviral vectors expressing human endostatin-angiostatin and soluble Tie2: enhanced suppression of tumor growth and antiangiogenic effects in a prostate tumor model
    Sudhanshu P Raikwar
    Department of Urology, Indiana University School of Medicine, 535 Barnhill Drive, Indianapolis, IN 46202, USA
    Mol Ther 12:1091-100. 2005
    ..These results suggest that a combinatorial antiangiogenic gene therapy approach involving Ad-hEndo-angio and Ad-sTie2 could become a novel form of treatment for localized human prostate cancer...
  48. pmc Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury
    Ravindra L Mehta
    Department of Medicine, University of California San Diego Medical Center 8342, 200 W, Arbor Drive, San Diego, CA 92103, USA
    Crit Care 11:R31. 2007
    ..We describe an initiative to develop uniform standards for defining and classifying AKI and to establish a forum for multidisciplinary interaction to improve care for patients with or at risk for AKI...
  49. ncbi request reprint Transitioning to therapy in ischemic acute renal failure
    Bruce A Molitoris
    J Am Soc Nephrol 14:265-7. 2003
  50. doi request reprint Bacterial infection-mediated mucosal signalling induces local renal ischaemia as a defence against sepsis
    Keira Melican
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Cell Microbiol 10:1987-98. 2008
    ..Suppression of clotting by heparin treatment caused fatal urosepsis. Clinically these findings may be relevant in antibiotics delivery in pyelonephritis patients and to the use of anticoagulants in sepsis...
  51. ncbi request reprint Improvements in the diagnosis of acute kidney injury
    Vyacheslav Y Melnikov
    Saudi J Kidney Dis Transpl 19:537-44. 2008
    ..There is also potential that a number of serum and urine bio-markers developed in preclinical studies and currently being investigated and validated, will enable the early diagnosis of AKI...
  52. ncbi request reprint Incidence and mortality of acute renal failure in Medicare beneficiaries, 1992 to 2001
    Jay L Xue
    United States Renal Data System, 914 South 8th Street, Suite D 206, Minneapolis, MN 55404, USA
    J Am Soc Nephrol 17:1135-42. 2006
    ..Those of older age, male gender, and black race are more likely to have ARF. These data show ARF to be a major contributor to morbidity and mortality in hospitalized patients...
  53. ncbi request reprint Advances in imaging the kidney and cellular processes
    Stefan Herget-Rosenthal
    Department of Nephrology, University Hospital Essen, University Duisburg Essen, Essen, Germany
    Nephron Exp Nephrol 103:e31-2. 2006
  54. ncbi request reprint Improving outcomes from acute kidney injury: report of an initiative
    Adeera Levin
    Am J Kidney Dis 50:1-4. 2007
  55. ncbi request reprint Improving outcomes from acute kidney injury
    Bruce A Molitoris
    J Am Soc Nephrol 18:1992-4. 2007
  56. ncbi request reprint Improving outcomes from acute kidney injury: report of an initiative
    Arvind Bagga
    Pediatr Nephrol 22:1655-8. 2007
    ..The vital role of multi-disciplinary conferences for disseminating knowledge and clarifying issues in clinical practice was recognized...
  57. ncbi request reprint Real-time studies of the progression of bacterial infections and immediate tissue responses in live animals
    Lisa E Månsson
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Cell Microbiol 9:413-24. 2007
    ..The techniques described here can be applied to study the integrated cell communication evoked by a variety of bacterial pathogens, assisting in the design of strategies to combat bacterial infections...

Research Grants9

  1. RAB5 AND PI-3-KINASE AND GENTAMICIN TOXICITY
    Bruce Molitoris; Fiscal Year: 2002
    ..By performing these studies, it is hoped that formulation of specific therapies to delay and/or inhibit this toxicity will become possible. ..
  2. Center for Advanced Renal Microscopic Analysis
    Bruce Molitoris; Fiscal Year: 2006
    ..The research development and support activities of the imaging facility are expected to provide numerous opportunities to impact the understanding of renal disease processes and therapeutic interventions. ..
  3. Ischemia-induced Actin Cytoskeletal Alterations
    Bruce Molitoris; Fiscal Year: 2007
    ..abstract_text> ..
  4. Center for Advanced Renal Microscopic Analysis
    Bruce Molitoris; Fiscal Year: 2007
    ..These research development and support activities are expected to provide numerous opportunities to impact the understanding of renal physiology, disease processes and therapeutic interventions. ..