S M Moe

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. doi request reprint The pathophysiology of early-stage chronic kidney disease-mineral bone disorder (CKD-MBD) and response to phosphate binders in the rat
    Sharon M Moe
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Bone Miner Res 26:2672-81. 2011
  2. ncbi request reprint Definition, evaluation, and classification of renal osteodystrophy: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO)
    S Moe
    Indiana University School of Medicine, Roudebush VAMC, Indianapolis, Indiana 46202, USA
    Kidney Int 69:1945-53. 2006
  3. ncbi request reprint Long-term treatment of secondary hyperparathyroidism with the calcimimetic cinacalcet HCl
    Sharon M Moe
    Indiana University Department of Medicine, 1001 West 10th Street, OPW 526, Indianapolis, IN 46202, USA
    Nephrol Dial Transplant 20:2186-93. 2005
  4. ncbi request reprint Role of calcification inhibitors in the pathogenesis of vascular calcification in chronic kidney disease (CKD)
    Sharon M Moe
    Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Kidney Int 67:2295-304. 2005
  5. ncbi request reprint Disorders of calcium, phosphorus, and magnesium
    Sharon M Moe
    Department of Medicine, Indiana University School of Medicine, and Roudebush VAMC, Indianapolis, IN 46202, USA
    Am J Kidney Dis 45:213-8. 2005
  6. ncbi request reprint Achieving NKF-K/DOQI bone metabolism and disease treatment goals with cinacalcet HCl
    Sharon M Moe
    Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Kidney Int 67:760-71. 2005
  7. ncbi request reprint Inflammation and vascular calcification
    Sharon M Moe
    Indiana University and Roudebush Veterans Affairs Medical Center, Indianapolis, IN 46260, USA
    Blood Purif 23:64-71. 2005
  8. ncbi request reprint Uremic vasculopathy
    Sharon M Moe
    Indiana University School of Medicine, Indianapolis, IN 46260, USA
    Semin Nephrol 24:413-6. 2004
  9. ncbi request reprint Pathophysiology of vascular calcification in chronic kidney disease
    Sharon M Moe
    Indiana University School of Medicine, Wishard Memorial Hospital, 1001 W 10th St, OPW 526 Indianapolis, IN 46202, USA
    Circ Res 95:560-7. 2004
  10. ncbi request reprint Natural history of vascular calcification in dialysis and transplant patients
    Sharon M Moe
    Departmrnt of Medicine, Indiana University School of Medicine, 1001 W 10th Street, OPW 526, Indianapolis, IN 46202, USA
    Nephrol Dial Transplant 19:2387-93. 2004

Detail Information

Publications77

  1. doi request reprint The pathophysiology of early-stage chronic kidney disease-mineral bone disorder (CKD-MBD) and response to phosphate binders in the rat
    Sharon M Moe
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Bone Miner Res 26:2672-81. 2011
    ..These results demonstrate marked abnormalities in kidney, intestine, and bone in early CKD-MBD. While phosphate binders were effective in lowering urine phosphorus, they had little effect on end organs after 1 week of administration...
  2. ncbi request reprint Definition, evaluation, and classification of renal osteodystrophy: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO)
    S Moe
    Indiana University School of Medicine, Roudebush VAMC, Indianapolis, Indiana 46202, USA
    Kidney Int 69:1945-53. 2006
    ..The international adoption of these recommendations will greatly enhance communication, facilitate clinical decision-making, and promote the evolution of evidence-based clinical practice guidelines worldwide...
  3. ncbi request reprint Long-term treatment of secondary hyperparathyroidism with the calcimimetic cinacalcet HCl
    Sharon M Moe
    Indiana University Department of Medicine, 1001 West 10th Street, OPW 526, Indianapolis, IN 46202, USA
    Nephrol Dial Transplant 20:2186-93. 2005
    ..Cinacalcet modulates the calcium-sensing receptor on the parathyroid gland to reduce secretion of parathyroid hormone and lower serum calcium, phosphorus and calcium-phosphorus product in haemodialysis patients...
  4. ncbi request reprint Role of calcification inhibitors in the pathogenesis of vascular calcification in chronic kidney disease (CKD)
    Sharon M Moe
    Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Kidney Int 67:2295-304. 2005
    ..This suggests protective mechanisms, or naturally occurring inhibitors, of calcification may be important...
  5. ncbi request reprint Disorders of calcium, phosphorus, and magnesium
    Sharon M Moe
    Department of Medicine, Indiana University School of Medicine, and Roudebush VAMC, Indianapolis, IN 46202, USA
    Am J Kidney Dis 45:213-8. 2005
  6. ncbi request reprint Achieving NKF-K/DOQI bone metabolism and disease treatment goals with cinacalcet HCl
    Sharon M Moe
    Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Kidney Int 67:760-71. 2005
    ....
  7. ncbi request reprint Inflammation and vascular calcification
    Sharon M Moe
    Indiana University and Roudebush Veterans Affairs Medical Center, Indianapolis, IN 46260, USA
    Blood Purif 23:64-71. 2005
    ..The combination of the acceleration of vascular calcification together with impaired defense mechanisms creates a uremic milieu primed for extra-osseous calcification...
  8. ncbi request reprint Uremic vasculopathy
    Sharon M Moe
    Indiana University School of Medicine, Indianapolis, IN 46260, USA
    Semin Nephrol 24:413-6. 2004
    ..Further understanding of the pathophysiology of uremic vascular calcification is needed to design effective therapeutic strategies to intervene with this devastating condition in ESRD patients...
  9. ncbi request reprint Pathophysiology of vascular calcification in chronic kidney disease
    Sharon M Moe
    Indiana University School of Medicine, Wishard Memorial Hospital, 1001 W 10th St, OPW 526 Indianapolis, IN 46202, USA
    Circ Res 95:560-7. 2004
    ..This nidus can then mineralize if the balance of pro-mineralizing factors outweighs inhibitory factors...
  10. ncbi request reprint Natural history of vascular calcification in dialysis and transplant patients
    Sharon M Moe
    Departmrnt of Medicine, Indiana University School of Medicine, 1001 W 10th Street, OPW 526, Indianapolis, IN 46202, USA
    Nephrol Dial Transplant 19:2387-93. 2004
    ..The purpose of the present study was to determine the natural history of coronary artery and aorta calcification by spiral computed tomography (CT) in patients who undergo a renal transplant and patients on haemodialysis...
  11. ncbi request reprint Management of renal osteodystrophy in peritoneal dialysis patients
    Sharon M Moe
    Department of Medicine Nephrology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Perit Dial Int 24:209-16. 2004
    ..The unique aspects of the approach to renal osteodystrophy in PD patients are the focus of this review...
  12. ncbi request reprint Vascular calcification and renal osteodystrophy relationship in chronic kidney disease
    S M Moe
    Indiana University School of Medicine and Roudebush Veterans Affairs Medical Center, Indianapolis, IN 46202, USA
    Eur J Clin Invest 36:51-62. 2006
    ..The coexistence of vascular risk factors and abnormal bone represent a double threat to the well being of patients with CKD...
  13. ncbi request reprint Vascular calcification: Hardening of the evidence
    S M Moe
    Indiana University School of Medicine, Roudebush Veterans Administration Medical Center, Clarian Health Partners, Indianapolis, Indiana 46202, USA
    Kidney Int 70:1535-7. 2006
    ..Additional advances in imaging techniques have facilitated the diagnosis of arterial calcification, a critical initial step in the translation of this knowledge to patient care...
  14. ncbi request reprint Chronic kidney disease-mineral-bone disorder: a new paradigm
    Sharon M Moe
    Indiana University School of Medicine and Roudebush VAMC, Indianapolis, IN 46202, USA
    Adv Chronic Kidney Dis 14:3-12. 2007
    ..The pathogenesis and clinical manifestations of these components of CKD-MBD are described in detail in this issue of Advances in Chronic Kidney Disease...
  15. pmc Vegetarian compared with meat dietary protein source and phosphorus homeostasis in chronic kidney disease
    Sharon M Moe
    Department of Medicine, Indiana University School of Medicine, 1001 West 10th Street, OPW 526, Indianapolis, IN 46202, USA
    Clin J Am Soc Nephrol 6:257-64. 2011
    ..This provides the rationale for recommendations to restrict dietary phosphate intake to 800 mg/d. However, the protein source of the phosphate may also be important...
  16. ncbi request reprint Confusion on the complexity of calcium balance
    Sharon M Moe
    Departments of Medicine, Anatomy and Cell Biology, Indiana University School of Medicine, Roudebush Veterans Administration Hospital, Indianapolis, Indiana 46260, USA
    Semin Dial 23:492-7. 2010
    ..Thus, it is best to prevent the calcium overload in the first place by avoiding high-dose calcium-based phosphate binders and optimizing bone remodeling...
  17. pmc A randomized trial of cholecalciferol versus doxercalciferol for lowering parathyroid hormone in chronic kidney disease
    Sharon M Moe
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Clin J Am Soc Nephrol 5:299-306. 2010
    ..The optimal treatment of secondary hyperparathyroidism in chronic kidney disease (CKD) is unknown...
  18. doi request reprint R-568 reduces ectopic calcification in a rat model of chronic kidney disease-mineral bone disorder (CKD-MBD)
    Sharon M Moe
    Indiana University School of Medicine, Roudebush Veterans Affairs Medical Center, Indianapolis, IN, USA
    Nephrol Dial Transplant 24:2371-7. 2009
    ....
  19. pmc Improving global outcomes in mineral and bone disorders
    Sharon M Moe
    Department of Medicine, Indiana University School of Medicine, Roudebush VA Medical Center, 1001 W 10th Street, OPW 526, Indianapolis, IN 46202, USA
    Clin J Am Soc Nephrol 3:S127-30. 2008
    ..The use of a common, internationally accepted terminology should ease the comparison of studies in this field and eventually improve patient care worldwide...
  20. pmc A rat model of chronic kidney disease-mineral bone disorder
    Sharon M Moe
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46260, USA
    Kidney Int 75:176-84. 2009
    ..This model should help identify early changes in the course of chronic kidney disease that may lead to CKD-MBD...
  21. pmc Disorders involving calcium, phosphorus, and magnesium
    Sharon M Moe
    Department of Medicine, Division of Nephrology, Indiana University School of Medicine, 1001 West 10th Street, OPW 526, Indianapolis, IN 46202, USA
    Prim Care 35:215-37, v-vi. 2008
    ....
  22. pmc Association of hepatitis C virus infection with prevalence and development of kidney disease
    Sharon M Moe
    Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Am J Kidney Dis 51:885-92. 2008
    ..Data showed that hepatitis C may be causally linked to some glomerular diseases, and patients who are positive for hepatitis C have increased risk of albuminuria...
  23. ncbi request reprint Mechanisms of vascular calcification in chronic kidney disease
    Sharon M Moe
    Department of Medicine, Indiana University, 1001 W 10th Street, OPW 526, Indianapolis, IN 46202, USA
    J Am Soc Nephrol 19:213-6. 2008
    ..Together these factors increase risk and complicate the management of vascular calcification...
  24. ncbi request reprint The case against calcium-based phosphate binders
    Sharon M Moe
    Department of Medicine, Indiana University School of Medicine, 1001 W 10th Street, OPW 526, Indianapolis, IN 46260, USA
    Clin J Am Soc Nephrol 1:697-703. 2006
    ..Therefore, calcium-based phosphate binders should be avoided in many, if not most, patients who are undergoing dialysis...
  25. ncbi request reprint Calciphylaxis and vascular calcification: a continuum of extra-skeletal osteogenesis
    Sharon M Moe
    Indiana University School of Medicine, 1001 W 10th Street, Indianapolis, Indiana, USA 46202
    Pediatr Nephrol 18:969-75. 2003
  26. ncbi request reprint Management of secondary hyperparathyroidism: the importance and the challenge of controlling parathyroid hormone levels without elevating calcium, phosphorus, and calcium-phosphorus product
    Sharon M Moe
    Department of Medicine, Division of Nephrology, Indiana University School of Medicine and Roudebush Veterans Affairs Medical Center, Indianapolis, Ind 46202, USA
    Am J Nephrol 23:369-79. 2003
    ..In addition, the development of new, more physiologically relevant therapies, which may lead to successful management of secondary HPT, is reviewed...
  27. ncbi request reprint Current issues in the management of secondary hyperparathyroidism and bone disease
    S M Moe
    Wishard Memorial Hospital, Indiana University School of Medicine, Indianapolis 46202, USA
    Perit Dial Int 21:S241-6. 2001
    ..5 mg/dL, a Ca x P product of <55 mg/dL, and a PTH of around 150-200 pg/mL with the intact assay. Ten years ago, those goals would have been impossible. However, new pharmacologic agents will make their achievement much more realistic...
  28. ncbi request reprint Medial artery calcification in ESRD patients is associated with deposition of bone matrix proteins
    Sharon M Moe
    Department of Medicine, Indiana University School of Medicine and Roudebush Veterans Affairs Medical Center, Indianapolis, Indiana 46202, USA
    Kidney Int 61:638-47. 2002
    ..Patients with ESRD are known to have excessive vascular calcification, but this has previously been attributed to the non-cell-mediated process of metastatic calcification...
  29. ncbi request reprint A placebo-controlled trial to evaluate immunomodulatory effects of paricalcitol
    S M Moe
    Department of Medicine, Divisions of Nephrology and Biostatistics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Am J Kidney Dis 38:792-802. 2001
    ..Thus, patients with low PTH levels are unlikely to experience the proimmune effects of vitamin D therapy without more profound and potentially adverse oversuppression of PTH...
  30. ncbi request reprint Uremia induces the osteoblast differentiation factor Cbfa1 in human blood vessels
    Sharon M Moe
    Department of Medicine, Indiana University School of Medicine and Roudebush Veterans Affairs Medical Center, Indianapolis, Indiana 46202, USA
    Kidney Int 63:1003-11. 2003
    ..One of the key transcriptional regulators of osteoblast differentiation is Cbfa1. Thus, we hypothesized that this may be a key factor in arterial calcification...
  31. ncbi request reprint Assessment of vascular calcification in ESRD patients using spiral CT
    Sharon M Moe
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Nephrol Dial Transplant 18:1152-8. 2003
    ..The purpose of the present study was to utilize an alternative machine, spiral CT, to assess calcification in end-stage renal disease (ESRD) patients...
  32. ncbi request reprint The role of the synovium and cartilage in the pathogenesis of beta(2)-microglobulin amyloidosis
    S M Moe
    Department of Medicine, Indiana University School of Medicine and Richard L Roudebush VA Medical Center, Indianapolis, Indiana, USA
    Semin Dial 14:127-30. 2001
    ..Thus beta(2)M itself may elicit the release of inflammatory mediators from synovial fibroblasts even in the absence of cellular infiltrates...
  33. ncbi request reprint beta2-microglobulin induces MMP-1 but not TIMP-1 expression in human synovial fibroblasts
    S M Moe
    Division of Nephrology, Indiana University School of Medicine and Richard Roudebush Veterans Administration Medical Center, Indianapolis, IN 46202, USA
    Kidney Int 57:2023-34. 2000
    ..We hypothesized that one of the mechanisms by which beta2m induces joint destruction is to induce the release of matrix metalloproteinase-1 (MMP-1), but not tissue inhibitor of metalloproteinase-1 (TIMP-1), from synovial fibroblasts...
  34. ncbi request reprint A bridge to improving healthcare outcomes and quality of life
    Sharon M Moe
    Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Am J Kidney Dis 43:552-7. 2004
  35. ncbi request reprint A coculture model of synoviocytes and bone for the evaluation of potential arthritis therapies
    S M Moe
    Department of Medicine, Indiana University Medical Center, Wishard Memorial Hospital, Indianapolis 46202, USA
    J Pharmacol Toxicol Methods 41:127-34. 1999
    ..To evaluate the symbiotic relationship between musculoskeletal cells in the intact joint utilizing a coculture system and to determine if the model can be utilized to evaluate potential treatments for articular diseases...
  36. ncbi request reprint Distal calcific uremic arteriolopathy in a hemodialysis patient responds to lowering of Ca x P product and aggressive wound care
    R Russell
    Department of Veterans Affairs, Medicine Service, Indianapolis, Indiana 46202, USA
    Clin Nephrol 58:238-43. 2002
    ..Our studies support that lowering of elevated serum phosphorus, calcium, and Ca x P product, together with aggressive wound care may contribute to the successful outcome of patients with CUA...
  37. ncbi request reprint Management of chronic kidney disease mineral-bone disorder
    Stephen Z Fadem
    Baylor College of Medicine, Division of Nephrology, Houston, TX, USA
    Adv Chronic Kidney Dis 14:44-53. 2007
    ..Future therapies and guidelines should, therefore, also emphasize the need for earlier detection and management of CKD, shaped by the results of valid clinical trials...
  38. ncbi request reprint beta(2)-Microglobulin increases the expression of vascular cell adhesion molecule on human synovial fibroblasts
    M I Jaradat
    Department of Medicine, Indiana University School of Medicine, and Richard Roudebush VAMC, Indianapolis, Indiana, USA
    Kidney Int 59:1951-9. 2001
    ..CONCLUSION: beta2m directly increases the expression of VCAM-1 by synovial fibroblasts, indicating that synovial fibroblasts may play a key role in the pathogenesis of beta(2)m amyloidosis...
  39. ncbi request reprint The role of vitamin D in vascular calcification in chronic kidney disease
    Godwin O Wolisi
    Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Semin Dial 18:307-14. 2005
    ..However, prospective randomized trials in CKD patients are necessary to fully understand the impact of calcitriol and analog therapy on vascular calcification...
  40. ncbi request reprint Prevalence of calcidiol deficiency in CKD: a cross-sectional study across latitudes in the United States
    Robert E LaClair
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Am J Kidney Dis 45:1026-33. 2005
    ....
  41. ncbi request reprint Calciphylaxis is associated with hyperphosphatemia and increased osteopontin expression by vascular smooth muscle cells
    S Ahmed
    Departments of Medicine, Pathology, and Anatomy, Indiana University School of Medicine, Indianapolis 46202, USA
    Am J Kidney Dis 37:1267-76. 2001
    ..Histologic examination suggests that the calcification is associated with increased expression of osteopontin by smooth muscle cells...
  42. pmc Precision of biomarkers to define chronic inflammation in CKD
    Robert LaClair
    Indiana University School of Medicine, Indianapolis, Indiana, USA
    Am J Nephrol 28:808-12. 2008
    ..The purpose of the present study was to determine the intrapatient variation of C-reactive protein, IL-6, fetuin-A and albumin in a population of dialysis patients...
  43. ncbi request reprint Cellular uptake of beta2M and AGE-beta2M in synovial fibroblasts and macrophages
    Kalisha D O'Neill
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Nephrol Dial Transplant 18:46-53. 2003
    ..Conversely, in human monocyte/macrophages, AGE-beta(2)M stimulates cytokine release whereas beta(2)M is less potent...
  44. ncbi request reprint The mechanisms of uremic serum-induced expression of bone matrix proteins in bovine vascular smooth muscle cells
    N X Chen
    Indiana University School of Medicine, Indianapolis, Indiana, USA
    Kidney Int 70:1046-53. 2006
    ..BMP-2 is also increased in uremic serum and can upregulate RUNX2 and calcification in vitro in VSMCs...
  45. ncbi request reprint Evaluation of Cinacalcet Therapy to Lower Cardiovascular Events (EVOLVE): rationale and design overview
    Glenn M Chertow
    Department of Medicine, University of California at San Francisco, San Francisco, California, USA
    Clin J Am Soc Nephrol 2:898-905. 2007
    ..However, no prospective trials have evaluated whether interventions that modify these laboratory parameters result in a reduction in adverse cardiovascular outcomes...
  46. ncbi request reprint Effect of hemodialysis membranes on beta 2-microglobulin amyloidosis
    M I Jaradat
    Indiana University School of Medicine and Richard Roudebush VA Medical Center, Indianapolis, Indiana 46202, USA
    Semin Dial 14:107-12. 2001
    ..However, it is possible that with the continuing advances in optimizing the beta(2)M removal efficiency of the different membranes, the frequency and severity of the disease can be substantially decreased...
  47. pmc Annexin-mediated matrix vesicle calcification in vascular smooth muscle cells
    Neal X Chen
    Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Bone Miner Res 23:1798-805. 2008
    ..In conclusion, our results suggest that mineralization in VSMCs requires both active MVs and an interaction of the MVs with type I collagen, and both steps require annexin activity...
  48. pmc Calcimimetic inhibits late-stage cyst growth in ADPKD
    Vincent H Gattone
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, Indiana 46202, USA
    J Am Soc Nephrol 20:1527-32. 2009
    ..The benefit of R-568 alone suggests calcium-sensing receptor modulation may have additional inhibitory effects on late-stage cyst growth resulting from a direct modulation of intracellular calcium...
  49. ncbi request reprint Signal transduction of beta2m-induced expression of VCAM-1 and COX-2 in synovial fibroblasts
    Neal X Chen
    Indiana University School of Medicine and Richard L Roudebush VAMC, Indianapolis, Indiana, USA
    Kidney Int 61:414-24. 2002
    ..We have demonstrated that beta2m increases the expression of vascular cell adhesion molecule (VCAM-1) and cyclooxygenase-2 (COX-2) in human osteoarthritic synovial fibroblasts (SFLs)...
  50. doi request reprint Verapamil inhibits calcification and matrix vesicle activity of bovine vascular smooth muscle cells
    Neal X Chen
    Division of Nephrology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Kidney Int 77:436-42. 2010
    ....
  51. pmc Vancomycin pharmacokinetics and pharmacodynamics during short daily hemodialysis
    Brian S Decker
    Indiana University School of Medicine, Indianapolis, IN, USA
    Clin J Am Soc Nephrol 5:1981-7. 2010
    ..Short daily hemodialysis (SDHD) is an alternative to thrice-weekly HD because of its putative physiologic benefits. The purpose of this study was to investigate the effect of SDHD on the pharmacokinetics and pharmacodynamics of vancomycin...
  52. pmc RhoA/Rho kinase (ROCK) alters fetuin-A uptake and regulates calcification in bovine vascular smooth muscle cells (BVSMC)
    Neal X Chen
    Indiana Univ School of Medicine, Indianapolis, IN 46202, USA
    Am J Physiol Renal Physiol 299:F674-80. 2010
    ..These results demonstrate that the RhoA/ROCK signaling pathway is an important negative regulator of vascular calcification...
  53. ncbi request reprint Effects of sevelamer hydrochloride and calcium acetate on the oral bioavailability of ciprofloxacin
    Michael B Kays
    Department of Pharmacy Practice, Purdue University School of Pharmacy and Pharmacal Sciences, Indianapolis, IN, USA, West Lafayette, IN 46202 2879, USA
    Am J Kidney Dis 42:1253-9. 2003
    ..The authors conducted a 3-way, randomized, crossover study to determine the effects of sevelamer hydrochloride and calcium acetate on the relative oral bioavailability of ciprofloxacin...
  54. ncbi request reprint Fetuin-A uptake in bovine vascular smooth muscle cells is calcium dependent and mediated by annexins
    Neal X Chen
    Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Am J Physiol Renal Physiol 292:F599-606. 2007
    ..This regulated uptake may be a mechanism by which fetuin-A inhibits VSMC calcification in the presence of excess calcium...
  55. ncbi request reprint Phosphorus and uremic serum up-regulate osteopontin expression in vascular smooth muscle cells
    Neal X Chen
    Indiana University School of Medicine, and Richard L Roudebush Veterans Administration Medical Center, Indianapolis, Indiana, USA
    Kidney Int 62:1724-31. 2002
    ..Dialysis patients have accelerated atherosclerosis, with extensive calcification of both the intima and media. Cross-sectional studies have implicated hyperphosphatemia in this process, but the mechanism is unclear...
  56. ncbi request reprint Arterial calcification in diabetes
    Neal X Chen
    Department of Medicine, Indiana University School of Medicine, 1001 West 10th Street, OPW 526, Indianapolis, IN 46202, USA
    Curr Diab Rep 3:28-32. 2003
    ..Further understanding of the mechanism by which diabetes induces this complication is needed to design effective therapeutic strategies to intervene with this process...
  57. ncbi request reprint Vascular calcification in chronic kidney disease
    Neal X Chen
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Semin Nephrol 24:61-8. 2004
    ..In addition, it is likely that circulating inhibitors of calcification are also important. Further understanding of the pathophysiology of vascular calcification is needed to intervene appropriately...
  58. ncbi request reprint Uremic vascular calcification
    Neal X Chen
    Department of Medicine, Indiana Univeristy School of Medicine, Indianapolis, IN 46202, USA
    J Investig Med 54:380-4. 2006
    ..Further understanding of the pathophysiology of uremic vascular calcification is needed to design effective therapeutic strategies to intervene with this devastating condition in patients with stage V chronic kidney disease...
  59. ncbi request reprint High glucose increases the expression of Cbfa1 and BMP-2 and enhances the calcification of vascular smooth muscle cells
    Neal X Chen
    Indiana University School of Medicine, 1001 West 10th Street, WD, OPW 526, Indianapolis, IN 46202, USA
    Nephrol Dial Transplant 21:3435-42. 2006
    ..Vascular calcification is common in diabetes but the pathogenesis is poorly understood...
  60. ncbi request reprint Vascular calcification in dialysis patients: pathogenesis and consequences
    Martina Reslerova
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Am J Kidney Dis 41:S96-9. 2003
    ..Vascular calcification is believed to have a crucial role in the excess cardiovascular mortality and morbidity in patients with end-stage renal disease (ESRD)...
  61. ncbi request reprint Fish consumption and omega-3 fatty acid status and determinants in long-term hemodialysis
    Allon N Friedman
    Division of Nephrology, Indiana University School of Medicine, Indianapolis, IN, USA
    Am J Kidney Dis 47:1064-71. 2006
    ..There is reason to believe that hemodialysis patients are at risk for inadequate omega-3 intake and, consequently, low blood levels...
  62. doi request reprint Review article: Chronic kidney disease-mineral bone disorder: have we got the assays right?
    Miriam P Zidehsarai
    Department of Medicine, Indiana University School of Medicine, 1001 W 10th Street, Indianapolis, IN 46202, USA
    Nephrology (Carlton) 14:374-82. 2009
    ....
  63. ncbi request reprint Vitamin D, cardiovascular disease, and survival in dialysis patients
    Sharon M Moe
    Indiana University School of Medicine and Roudebush VAMC, Indianapolis, Indiana, USA
    J Bone Miner Res 22:V95-9. 2007
    ..The unknown is what type and how much to give, and whether this approach is safe, especially in patients with low levels of PTH...
  64. ncbi request reprint Cinacalcet hydrochloride: a viewpoint by Sharon M. Moe
    Sharon M Moe
    Indiana University School of Medicine, Indianapolis, Indiana, USA
    Drugs 65:282-3. 2005
  65. doi request reprint Skeletal effects of zoledronic acid in an animal model of chronic kidney disease
    M R Allen
    Department of Anatomy and Cell Biology, MS 5035, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA
    Osteoporos Int 24:1471-81. 2013
    ..Bisphosphonates reduce skeletal loss and fracture risk, but their use has been limited in patients with chronic kidney disease. This study shows skeletal benefits of zoledronic acid in an animal model of chronic kidney disease...
  66. ncbi request reprint Efficacy of sodium thiosulfate for the treatment for calciphylaxis
    L Noureddine
    Division of Nephrology, Indiana University, University School of Medicine, Indianapolis, IN 46202, USA
    Clin Nephrol 75:485-90. 2011
    ..Calciphylaxis is a rare condition with dismal prognosis that affects patients with ESRD. Sodium thiosulfate (STS) may play a therapeutic role but its proposed efficacy is based on case reports and thus subject to publication bias...
  67. ncbi request reprint Identity and localization of advanced glycation end products on human beta2-microglobulin using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
    Ross R Cocklin
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Anal Biochem 314:322-5. 2003
  68. ncbi request reprint Oral fish oil supplementation raises blood omega-3 levels and lowers C-reactive protein in haemodialysis patients--a pilot study
    Akber Saifullah
    Division of Nephrology, Indiana University School of Medicine, Indianapolis IN, USA
    Nephrol Dial Transplant 22:3561-7. 2007
    ....
  69. doi request reprint Medication changes based on echocardiography in dialysis patients
    Chun K Chong
    Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Hemodial Int 13:472-8. 2009
    ..Further studies are warranted to demonstrate evidence for the use of serial screening echocardiography in this high-risk population...
  70. ncbi request reprint Disturbances of bone and mineral metabolism in chronic kidney disease: an international initiative to improve diagnosis and treatment
    Tilman B Drueke
    Nephrol Dial Transplant 19:534-6. 2004
  71. ncbi request reprint Management of chronic kidney disease-mineral bone disorder
    Stephen Z Fadem
    Adv Chronic Kidney Dis 14:2. 2007
  72. doi request reprint Variation in serum and plasma PTH levels in second-generation assays in hemodialysis patients: a cross-sectional study
    Dominique Joly
    Service de Nephrologie, Laboratoire d Explorations Fonctionnelles and Inserm Unit 845, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, Paris, France
    Am J Kidney Dis 51:987-95. 2008
    ..In this cross-sectional study, we aim to determine the usefulness of standardizing blood handling for optimal interpretation of PTH in patients with chronic kidney disease...
  73. ncbi request reprint Introduction. Renal osteodystrophy
    Jill S Lindberg
    Semin Nephrol 24:1-2. 2004
  74. ncbi request reprint The calcimimetic AMG 073 reduces parathyroid hormone and calcium x phosphorus in secondary hyperparathyroidism
    Jill S Lindberg
    Ochsner Clinical Research Center, New Orleans, Louisiana 70121, USA
    Kidney Int 63:248-54. 2003
    ..The calcimimetic AMG 073 increases the sensitivity of the parathyroid calcium-sensing receptor to extracellular calcium, thereby reducing PTH secretion. Consequently, AMG 073 may provide a novel therapy for secondary hyperparathyroidism...
  75. ncbi request reprint Calcification or classification?
    Glenn M Chertow
    J Am Soc Nephrol 16:293-5. 2005
  76. ncbi request reprint Cinacalcet for secondary hyperparathyroidism in patients receiving hemodialysis
    Geoffrey A Block
    Denver Nephrologists, Denver, USA
    N Engl J Med 350:1516-25. 2004
    ..We report the results of two identical randomized, double-blind, placebo-controlled trials evaluating the safety and effectiveness of the calcimimetic agent cinacalcet hydrochloride...
  77. ncbi request reprint Detection of chronic kidney disease in patients with or at increased risk of cardiovascular disease: a science advisory from the American Heart Association Kidney And Cardiovascular Disease Council; the Councils on High Blood Pressure Research, Cardiovasc
    Frank C Brosius
    Circulation 114:1083-7. 2006
    ..All patients with cardiovascular disease should be screened for evidence of kidney disease with these two determinations...

Research Grants3

  1. Musculoskeletal Disorder in Dialysis Patients
    Sharon Moe; Fiscal Year: 2007
    ..These studies, Dr. Moe, and the strong clinical research support at Indiana Unviersity provide an excellent training environment for the development of future investigators in patient oriented research. ..
  2. Bisphosphonates in the treatment of chronic kidney disease-mineral bone disease
    Sharon M Moe; Fiscal Year: 2010
    ..Both of these problems may be linked. The purpose of this study is to determine if a commonly used group of drugs, bisphosphonates, may help both bone and heart/blood vessel disease and determine the mechanism the drugs work. ..