C J McDougle

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. ncbi request reprint A double-blind, placebo-controlled study of risperidone in adults with autistic disorder and other pervasive developmental disorders
    C J McDougle
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis 46202 5200, USA
    Arch Gen Psychiatry 55:633-41. 1998
  2. ncbi request reprint Neurochemistry in the pathophysiology of autism
    Christopher J McDougle
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202 4800, USA
    J Clin Psychiatry 66:9-18. 2005
  3. ncbi request reprint Possible role of neuropeptides in obsessive compulsive disorder
    C J McDougle
    Indiana University School of Medicine, Department of Psychiatry, Indianapolis 46202, USA
    Psychoneuroendocrinology 24:1-24. 1999
  4. ncbi request reprint Research Units on Pediatric Psychopharmacology (RUPP) Autism Network. Background and rationale for an initial controlled study of risperidone
    C J McDougle
    University School of Medicine, Indianapolis, Indiana, USA
    Child Adolesc Psychiatr Clin N Am 9:201-24. 2000
  5. ncbi request reprint A double-blind, placebo-controlled study of risperidone addition in serotonin reuptake inhibitor-refractory obsessive-compulsive disorder
    C J McDougle
    Department of Psychiatry, Section of Child and Adolescent Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202 5200, USA
    Arch Gen Psychiatry 57:794-801. 2000
  6. ncbi request reprint Repetitive thoughts and behavior in pervasive developmental disorders: treatment with serotonin reuptake inhibitors
    C J McDougle
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, USA
    J Autism Dev Disord 30:427-35. 2000
  7. ncbi request reprint Atypical antipsychotics in children and adolescents with autistic and other pervasive developmental disorders
    Christopher J McDougle
    Department of Psychiatry, Indiana University School of Medicine, Christian Sarkine Autism Treatment Center, James Whitcomb Riley Hospital for Children, Indianapolis, IN 46202 4800, USA
    J Clin Psychiatry 69:15-20. 2008
  8. ncbi request reprint Risperidone for the core symptom domains of autism: results from the study by the autism network of the research units on pediatric psychopharmacology
    Christopher J McDougle
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202 4800, USA
    Am J Psychiatry 162:1142-8. 2005
  9. ncbi request reprint A retrospective analysis of quetiapine in the treatment of pervasive developmental disorders
    Adam H Corson
    Department of Psychiatry, Indiana University School of Medicine and Christian Sarkine Autism Treatment Center, James Whitcomb Riley Hospital for Children, Indianapolis, Ind 46202 4800, USA
    J Clin Psychiatry 65:1531-6. 2004
  10. ncbi request reprint Treatment of aggression in children and adolescents with autism and conduct disorder
    Christopher J McDougle
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Clin Psychiatry 64:16-25. 2003

Research Grants

  1. RUPP-PI
    Christopher McDougle; Fiscal Year: 2006
  2. Novel Pharmacological Strategies in Autism
    Christopher McDougle; Fiscal Year: 2009
  3. 1/4-RUPP Autism Network: Guanfacine for the Treatment of Hyperactivity in PDD
    Christopher J McDougle; Fiscal Year: 2010

Detail Information

Publications76

  1. ncbi request reprint A double-blind, placebo-controlled study of risperidone in adults with autistic disorder and other pervasive developmental disorders
    C J McDougle
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis 46202 5200, USA
    Arch Gen Psychiatry 55:633-41. 1998
    ..Open-label reports suggest that the serotonin2A-dopamine D2 antagonist risperidone may be safe and effective in reducing the interfering symptoms of patients with autism...
  2. ncbi request reprint Neurochemistry in the pathophysiology of autism
    Christopher J McDougle
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202 4800, USA
    J Clin Psychiatry 66:9-18. 2005
    ..As these efforts move forward, it will be important to begin to integrate genetic studies with those involving neuroimaging and postmortem research in each of these 3 areas, as well as with pharmacologic treatment approaches...
  3. ncbi request reprint Possible role of neuropeptides in obsessive compulsive disorder
    C J McDougle
    Indiana University School of Medicine, Department of Psychiatry, Indianapolis 46202, USA
    Psychoneuroendocrinology 24:1-24. 1999
    ....
  4. ncbi request reprint Research Units on Pediatric Psychopharmacology (RUPP) Autism Network. Background and rationale for an initial controlled study of risperidone
    C J McDougle
    University School of Medicine, Indianapolis, Indiana, USA
    Child Adolesc Psychiatr Clin N Am 9:201-24. 2000
    ..The design of this study and the assessments used are described separately...
  5. ncbi request reprint A double-blind, placebo-controlled study of risperidone addition in serotonin reuptake inhibitor-refractory obsessive-compulsive disorder
    C J McDougle
    Department of Psychiatry, Section of Child and Adolescent Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202 5200, USA
    Arch Gen Psychiatry 57:794-801. 2000
    ..This report describes the first controlled study of risperidone addition in patients with OCD refractory to treatment with SRI alone...
  6. ncbi request reprint Repetitive thoughts and behavior in pervasive developmental disorders: treatment with serotonin reuptake inhibitors
    C J McDougle
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, USA
    J Autism Dev Disord 30:427-35. 2000
    ..One controlled study of the selective SRI fluvoxamine found it to be significantly better than placebo for reducing repetitive phenomena and aggression in adults with autistic disorder. Additional research is needed...
  7. ncbi request reprint Atypical antipsychotics in children and adolescents with autistic and other pervasive developmental disorders
    Christopher J McDougle
    Department of Psychiatry, Indiana University School of Medicine, Christian Sarkine Autism Treatment Center, James Whitcomb Riley Hospital for Children, Indianapolis, IN 46202 4800, USA
    J Clin Psychiatry 69:15-20. 2008
    ..Additional placebo-controlled trials and studies of longer-term safety and tolerability are needed...
  8. ncbi request reprint Risperidone for the core symptom domains of autism: results from the study by the autism network of the research units on pediatric psychopharmacology
    Christopher J McDougle
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202 4800, USA
    Am J Psychiatry 162:1142-8. 2005
    ..The authors report on whether risperidone improves the core symptoms of autism, social and communication impairment and repetitive and stereotyped behavior...
  9. ncbi request reprint A retrospective analysis of quetiapine in the treatment of pervasive developmental disorders
    Adam H Corson
    Department of Psychiatry, Indiana University School of Medicine and Christian Sarkine Autism Treatment Center, James Whitcomb Riley Hospital for Children, Indianapolis, Ind 46202 4800, USA
    J Clin Psychiatry 65:1531-6. 2004
    ..The purpose of this study was to examine the effectiveness and tolerability of quetiapine for aggression, hyperactivity, and self-injury in pervasive developmental disorders (PDDs)...
  10. ncbi request reprint Treatment of aggression in children and adolescents with autism and conduct disorder
    Christopher J McDougle
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Clin Psychiatry 64:16-25. 2003
    ....
  11. ncbi request reprint Limited efficacy of ketoconazole in treatment-refractory major depression
    R T Malison
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    J Clin Psychopharmacol 19:466-70. 1999
    ..These findings suggest a limited efficacy for ketoconazole in patients with treatment-refractory major depression...
  12. ncbi request reprint A naturalistic open-label study of mirtazapine in autistic and other pervasive developmental disorders
    D J Posey
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, USA
    J Child Adolesc Psychopharmacol 11:267-77. 2001
    ..CONCLUSIONS: Mirtazapine was well tolerated but showed only modest effectiveness for treating the associated symptoms of autistic disorder and other PDDs...
  13. doi request reprint Pharmacotherapy of irritability in pervasive developmental disorders
    Kimberly A Stigler
    Department of Psychiatry, Indiana University School of Medicine, Riley Hospital for Children, Room 4300, 702 Barnhill Drive, Indianapolis, IN 46202 5200, USA
    Child Adolesc Psychiatr Clin N Am 17:739-52, vii-viii. 2008
    ..Additional large-scale, placebo-controlled studies of other medications are needed to determine their efficacy for the treatment of irritability in this diagnostic group...
  14. ncbi request reprint Case series: use of ziprasidone for maladaptive symptoms in youths with autism
    Christopher J McDougle
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis 46202 4800, USA
    J Am Acad Child Adolesc Psychiatry 41:921-7. 2002
    ..To conduct a preliminary evaluation of the safety and effectiveness of ziprasidone in children, adolescents, and young adults with autism...
  15. ncbi request reprint A retrospective study of memantine in children and adolescents with pervasive developmental disorders
    Craig A Erickson
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA
    Psychopharmacology (Berl) 191:141-7. 2007
    ..There are no drugs that have been shown to effectively treat the core social impairment of autism...
  16. ncbi request reprint Pharmacotherapeutic management of autism
    D J Posey
    Department of Psychiatry, Indaiana University School of Medicine, USA
    Expert Opin Pharmacother 2:587-600. 2001
    ..Current pharmacological management is best aimed at target symptoms that have been demonstrated to respond to medication in treatment studies...
  17. ncbi request reprint Open-label atomoxetine for attention-deficit/ hyperactivity disorder symptoms associated with high-functioning pervasive developmental disorders
    David J Posey
    Department of Psychiatry and Christian Sarkine Autism Treatment Center at the Indiana University School of Medicine, Indianapolis, Indiana, USA
    J Child Adolesc Psychopharmacol 16:599-610. 2006
    ..The aim of this study was to conduct an initial evaluation of the efficacy of atomoxetine for attention-deficit/hyperactivity disorder (ADHD) symptoms in children with pervasive developmental disorders (PDDs)...
  18. ncbi request reprint The use of selective serotonin reuptake inhibitors in autism and related disorders
    David J Posey
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Child Adolesc Psychopharmacol 16:181-6. 2006
    ..Larger, placebo-controlled studies of SSRIs are needed to guide clinical treatment...
  19. ncbi request reprint Risperidone in pervasive developmental disorders
    Craig A Erickson
    Riley Hospital, Child and Adolescent Psychiatry Clinic, 702 Barnhill Drive, ROC 4300, Indianapolis, IN 46202, USA
    Expert Rev Neurother 5:713-9. 2005
    ..Finally, a discussion of the future direction of risperidone use in this population and key issues will be presented...
  20. doi request reprint Serotoninergic mechanisms in the treatment of obsessive-compulsive disorder
    Andrew W Goddard
    Department of Psychiatry, Indiana University School of Medicine, University Hospital, UH3124, 550 North University Boulevard, Indianapolis, IN 46202, United States
    Drug Discov Today 13:325-32. 2008
    ..However, drug treatment approaches that modify function of interrelated neurochemical systems, such as the dopamine and glutamate systems, are also briefly discussed as they promise to complement and enhance SSRI treatment effects...
  21. ncbi request reprint Pharmacological augmentation strategies for treatment-resistant obsessive-compulsive disorder
    Kelda H Walsh
    Department of Psychiatry, Indiana University School of Medicine, Riley Hospital for Children, Room 4300, 702 Barnhill Drive, Indianapolis, IN 46202, USA
    Expert Opin Pharmacother 5:2059-67. 2004
    ..Future investigations should include more controlled studies and investigate medications that are less likely to trigger extrapyramidal symptoms, diabetes mellitus and weight gain...
  22. ncbi request reprint Ramelteon for insomnia in two youths with autistic disorder
    Kimberly A Stigler
    Department of Psychiatry, Indiana University School of Medicine and the Christian Sarkine Autism Treatment Center at the James Whitcomb Riley Hospital for Children, Indianapolis, Indiana 46202 5200, USA
    J Child Adolesc Psychopharmacol 16:631-6. 2006
    ..The aim of this study was to report preliminary data on the effectiveness and tolerability of ramelteon for the treatment of insomnia in youth with autistic disorder (autism)...
  23. pmc Aripiprazole in autism spectrum disorders and fragile X syndrome
    Craig A Erickson
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Neurotherapeutics 7:258-63. 2010
    ..However, research to date in this disorder has not focused on this target symptom cluster. An initial pilot study has begun to assess the impact of aripiprazole on irritability in youth with fragile X syndrome...
  24. ncbi request reprint Positive effects of methylphenidate on inattention and hyperactivity in pervasive developmental disorders: an analysis of secondary measures
    David J Posey
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Biol Psychiatry 61:538-44. 2007
    ....
  25. ncbi request reprint Guanfacine and guanfacine extended release: treatment for ADHD and related disorders
    David J Posey
    Christian Sarkine Autism Treatment Center, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA
    CNS Drug Rev 13:465-74. 2007
    ..Adverse cardiovascular effects are uncommon, although modest reductions in blood pressure and heart rate are common. If GXR is FDA-approved, it would be the first alpha(2A) adrenoceptor agonist marketed for ADHD...
  26. doi request reprint Brief report: acamprosate in fragile X syndrome
    Craig A Erickson
    Department of Psychiatry, Indiana University School of Medicine, 702 Barnhill Drive, Room 4300, Indianapolis, IN 46202, USA
    J Autism Dev Disord 40:1412-6. 2010
    ..Marked communication improvement was unexpected and has potential implications for the treatment of FXS, as well as idiopathic autism...
  27. pmc Developing drugs for core social and communication impairment in autism
    David J Posey
    Department of Psychiatry, Indiana University School of Medicine, 1111 West 10th Street, Indianapolis, IN 46202 4800, USA
    Child Adolesc Psychiatr Clin N Am 17:787-801, viii-ix. 2008
    ..More research is needed on the utility of selective serotonin reuptake inhibitors, cholinergic drugs, glutamatergic drugs, and oxytocin for core autistic symptoms...
  28. pmc Aripiprazole in pervasive developmental disorder not otherwise specified and Asperger's disorder: a 14-week, prospective, open-label study
    Kimberly A Stigler
    Department of Psychiatry, Section of Child and Adolescent Psychiatry, Indiana University School of Medicine and Christian Sarkine Autism Treatment Center, James Whitcomb Riley Hospital for Children, Indianapolis, Indiana 46202 5200, USA
    J Child Adolesc Psychopharmacol 19:265-74. 2009
    ..The aim of this study was to determine the effectiveness and tolerability of aripiprazole for irritability in pervasive developmental disorder not otherwise specified (PDD-NOS) and Asperger's disorder...
  29. pmc Antipsychotics in the treatment of autism
    David J Posey
    Christian Sarkine Autism Treatment Center, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Clin Invest 118:6-14. 2008
    ..Significant adverse effects, including weight gain and the possibility of tardive dyskinesia, are reviewed. Future research directions are discussed...
  30. ncbi request reprint Guanfacine treatment of hyperactivity and inattention in pervasive developmental disorders: a retrospective analysis of 80 cases
    David J Posey
    Department of Psychiatry, Indiana University School of Medicine, Riley Hospital for Children, 702 Barnhill Drive, Indianapolis, IN 46202 5200, USA
    J Child Adolesc Psychopharmacol 14:233-41. 2004
    ....
  31. ncbi request reprint Risperidone: a potential treatment for autism
    David J Posey
    Riley Hospital for Children, Indianapolis, IN 46202, USA
    Curr Opin Investig Drugs 3:1212-6. 2002
    ..Individuals with autism may also have other symptoms that become the primary focus of psychiatric treatment. These associated symptoms include aggression, self-injury, irritability and anxiety...
  32. ncbi request reprint Genetics of childhood disorders: XLIV. autism, part 3: psychopharmacology of autism
    Christopher J McDougle
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana, USA
    J Am Acad Child Adolesc Psychiatry 41:1380-3. 2002
  33. ncbi request reprint The pathophysiology and treatment of autism
    D J Posey
    Department of Psychiatry, Indiana University School of Medicine, 541 Clinical Drive, Indianapolis, IN 46202, USA
    Curr Psychiatry Rep 3:101-8. 2001
    ..Significant gains have been made in determining which pharmacologic treatments are efficacious in autism. Additional research is needed on agents that might ameliorate the core and associated symptoms of autism...
  34. ncbi request reprint A pilot study of D-cycloserine in subjects with autistic disorder
    David J Posey
    Riley Hospital for Children, Room 4300, 702 Barnhill Drive, Indianapolis, IN 46220, USA
    Am J Psychiatry 161:2115-7. 2004
    ..The authors assessed the effects of D-cycloserine on the core symptom of social impairment in subjects with autism...
  35. ncbi request reprint Aripiprazole for maladaptive behavior in pervasive developmental disorders
    Kimberly A Stigler
    Department of Psychiatry, Indiana University School of Medicine and the James Whitcomb Riley Hospital for Children, Indianapolis, IN 46202, USA
    J Child Adolesc Psychopharmacol 14:455-63. 2004
    ..The aim of this study was to obtain preliminary data regarding the effectiveness and tolerability of aripiprazole in the treatment of children and adolescents with a pervasive developmental disorder (PDD)...
  36. pmc Moderators, mediators, and other predictors of risperidone response in children with autistic disorder and irritability
    L Eugene Arnold
    Department of Psychiatry, Ohio State University, Columbus, Ohio, USA
    J Child Adolesc Psychopharmacol 20:83-93. 2010
    ..2 in favor of risperidone on the main outcome measure in an 8-week double-blind, placebo-controlled trial for irritability in autistic disorder. This paper explores moderators and mediators of this effect...
  37. ncbi request reprint Pharmacological strategies for trichotillomania
    Kelda H Walsh
    Department of Psychiatry, Indiana University School of Medicine, Riley Hospital for Children, Room 4300, 702 Barnhill Drive, Indianapolis, IN 46202, USA
    Expert Opin Pharmacother 6:975-84. 2005
    ..For other patients, other antidepressants, neuroleptics or even topical agents may be helpful. Future investigations should include more controlled studies and longer observation for relapse...
  38. ncbi request reprint Intramuscular ziprasidone for acute agitation in adolescents
    Emmeline Hazaray
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Child Adolesc Psychopharmacol 14:464-70. 2004
    ..In our study, we report the cases of 3 youngsters whose escalating aggression responded to intramuscular ziprasidone with an immediate calming effect and good clinical outcome...
  39. ncbi request reprint Trichotillomania. Presentation, etiology, diagnosis and therapy
    K H Walsh
    Indiana University School of Medicine, Indianapolis, Indiana, USA
    Am J Clin Dermatol 2:327-33. 2001
    ..Specialized psychotherapy, known as habit reversal training, is highly recommended; however, the treatment is intensive and highly specialized. Skilled therapists are difficult to locate...
  40. ncbi request reprint Weight gain associated with atypical antipsychotic use in children and adolescents: prevalence, clinical relevance, and management
    Kimberly A Stigler
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46202 4800, USA
    Paediatr Drugs 6:33-44. 2004
    ....
  41. ncbi request reprint Pharmacologic treatment of autism and related disorders
    Craig A Erickson
    Department of Psychiatry, Indiana University School of Medicine, and the Christian Sarkine Autism Treatment Center, James Whitcomb Riley Hospital for Children, Indianapolis 46202 4800, USA
    Pediatr Ann 36:575-85. 2007
  42. ncbi request reprint Increased prevalence of familial autoimmunity in probands with pervasive developmental disorders
    Thayne L Sweeten
    Department of Psychiatry, Indiana University School of Medicine, and James Whitcomb Riley Hospital for Children Indianapolis 46202 4800, USA
    Pediatrics 112:e420. 2003
    ..We further investigated this association by determining the frequency of autoimmune disorders in families that have probands with pervasive developmental disorders (PDDs), including autism, compared with 2 control groups...
  43. ncbi request reprint Synergistic action of 5-HT2A antagonists and selective serotonin reuptake inhibitors in neuropsychiatric disorders
    Gerard J Marek
    Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA
    Neuropsychopharmacology 28:402-12. 2003
    ....
  44. ncbi request reprint From anxiety to autism: spectrum of abnormal social behaviors modeled by progressive disruption of inhibitory neuronal function in the basolateral amygdala in Wistar rats
    William A Truitt
    Department of Psychiatry, Indiana University School of Medicine, 1111 West 10th Street, Indianapolis, IN 4620, USA
    Psychopharmacology (Berl) 191:107-18. 2007
    ..Social behaviors are disrupted in several psychiatric disorders. The amygdala is a key brain region involved in social behaviors, and amygdala pathology has been implicated in disease states ranging from social anxiety disorder to autism...
  45. ncbi request reprint Ziprasidone treatment of two adolescents with psychosis
    Karen G Meighen
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, USA
    J Child Adolesc Psychopharmacol 14:137-42. 2004
    ..These patients presented with hallucinations and grossly disorganized speech and behavior. Further study is needed to determine if these findings can be generalized...
  46. ncbi request reprint Pharmacological management of agitation and aggression in an adolescent with autism
    Christopher J Kratochvil
    Department of Psychiatry, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Am Acad Child Adolesc Psychiatry 44:829-32. 2005
  47. pmc Emerging drugs for the treatment of symptoms associated with autism spectrum disorders
    Logan K Wink
    Indiana University School of Medicine, Department of Psychiatry, Indianapolis, IN 46202, USA
    Expert Opin Emerg Drugs 15:481-94. 2010
    ..The use of pharmacologic agents in the treatment of these disorders can reduce the impact of interfering symptoms, providing relief for affected individuals and their families...
  48. ncbi request reprint A naturalistic retrospective analysis of psychostimulants in pervasive developmental disorders
    Kimberly A Stigler
    Department of Psychiatry, Indiana University School of Medicine, James Whitcomb Riley Hospital for Children, Indianapolis, Indiana, USA
    J Child Adolesc Psychopharmacol 14:49-56. 2004
    ..We set out to examine the effectiveness and tolerability of psychostimulants in children and adolescents with pervasive developmental disorders (PDDs)...
  49. ncbi request reprint Tolerability profile of atypical antipsychotics in children and adolescents
    K A Stigler
    Department of Psychiatry, Indiana University School of Medicine, 541 Clinical Drive, Indianapolis, IN 46202-5111, USA
    Paediatr Drugs 3:927-42. 2001
    ..Lack of evidence for bodyweight gain with ziprasidone is a considerable advantage...
  50. ncbi request reprint Acute onset of obsessive-compulsive disorder in an adolescent with acute lymphoblastic leukemia
    Douglas R Morris
    Section of Child and Adolescent Psychiatry, Department of Psychiatry, Indiana University School of Medicine, Bloomington, IN, USA
    Psychosomatics 46:458-60. 2005
  51. ncbi request reprint Brief report: autistic disorder in three children with cytomegalovirus infection
    Thayne L Sweeten
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202 4800, USA
    J Autism Dev Disord 34:583-6. 2004
    ..A better understanding of the immunologic response to certain congenital infections may provide important information pertaining to the pathophysiology and etiology of autism in vulnerable individuals...
  52. ncbi request reprint High blood monocyte counts and neopterin levels in children with autistic disorder
    Thayne L Sweeten
    Department of Psychiatry, Indiana University School of Medicine, 1111 West 10th Street, Indianapolis, IN 46202 4800, USA
    Am J Psychiatry 160:1691-3. 2003
    ..Leukocyte counts and plasma neopterin levels were determined in autistic children and matched healthy comparison subjects...
  53. ncbi request reprint Gastrointestinal factors in autistic disorder: a critical review
    Craig A Erickson
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis 46202 4800, USA
    J Autism Dev Disord 35:713-27. 2005
    ..While much literature is available on this topic, a dearth of rigorous study was found to validate GI factors specific to children with autism...
  54. doi request reprint Serotonin and dopamine transporter binding in children with autism
    Christopher J McDougle
    Dept of Psychiatry, Indiana University School of Medicine, USA
    Dev Med Child Neurol 50:565. 2008
  55. ncbi request reprint High nitric oxide production in autistic disorder: a possible role for interferon-gamma
    Thayne L Sweeten
    Department of Psychiatry, Indiana University School of Medicine, 1111 W 10th Street, Indianapolis, IN 46202 4800, USA
    Biol Psychiatry 55:434-7. 2004
    ..The purpose of this study was to verify that plasma NO is high in children with autism and determine whether this elevation is related to plasma levels of cytokines involved in NO production...
  56. ncbi request reprint The amygdala and related structures in the pathophysiology of autism
    Thayne L Sweeten
    Department of Psychiatry, Indiana University School of Medicine, 541 Clinical Drive, Room 298, Indianapolis, IN 46202 5111, USA
    Pharmacol Biochem Behav 71:449-55. 2002
    ..Although supportive evidence exists for amygdala dysfunction in autism, the currently available data are inconsistent and additional research is needed...
  57. ncbi request reprint Dietary status and impact of risperidone on nutritional balance in children with autism: a pilot study
    Ronald L Lindsay
    Children s Health Center of St Joseph s Hospital and Medical Center, Arizona 85013, USA
    J Intellect Dev Disabil 31:204-9. 2006
    ..Risperidone may be effective in improving tantrums, aggression, or self-injurious behaviour in children with autism, but often leads to weight gain...
  58. ncbi request reprint Acute tryptophan depletion in schizophrenic patients treated with clozapine
    Tony P George
    Arch Gen Psychiatry 59:291-2. 2002
  59. ncbi request reprint Parent-rated anxiety symptoms in children with pervasive developmental disorders: frequency and association with core autism symptoms and cognitive functioning
    Denis G Sukhodolsky
    The Child Study Center, Yale University, 230 South Frontage Road, New Haven, CT 06520, USA
    J Abnorm Child Psychol 36:117-28. 2008
    ..Limited data are available on the prevalence of anxiety in these children. We examined frequency and correlates of parent-rated anxiety symptoms in a large sample of children with PDD...
  60. ncbi request reprint Weight and leptin changes among risperidone-treated youths with autism: 6-month prospective data
    Andres Martin
    Yale Child Study Center, Yale University, New Haven, CT 06520, USA
    Am J Psychiatry 161:1125-7. 2004
    ..The authors examined the developmental impact and temporal characteristics of risperidone-associated weight change...
  61. ncbi request reprint Children's Yale-Brown Obsessive Compulsive Scale modified for pervasive developmental disorders
    Lawrence Scahill
    Yale Child Study Center, Yale University, New Haven, CT 06520, USA
    J Am Acad Child Adolesc Psychiatry 45:1114-23. 2006
    ..To examine the psychometric properties of the Children's Yale-Brown Obsessive Compulsive Scales (CYBOCS) modified for pervasive developmental disorders (PDDs)...
  62. ncbi request reprint Assessment of the integrity of study blindness in a pediatric clinical trial of risperidone
    Benedetto Vitiello
    Division of Services and Intervention Research, National Institute of Mental Health, Bethesda, MD 20892 9633, USA
    J Clin Psychopharmacol 25:565-9. 2005
    ..The blindness of clinical evaluators and parents was examined in a clinical trial of risperidone in autism...
  63. ncbi request reprint Risperidone and adaptive behavior in children with autism
    Susan K Williams
    Yale University, New Haven, CT 06520 7900, USA
    J Am Acad Child Adolesc Psychiatry 45:431-9. 2006
    ..To evaluate the impact of risperidone on adaptive behavior in children with autistic disorder who have serious behavior problems and to examine different methods of scoring the Vineland Adaptive Behavior Scales to measure change...
  64. ncbi request reprint Effects of short- and long-term risperidone treatment on prolactin levels in children with autism
    George M Anderson
    Child Study Center, Yale University School of Medicine, New Haven, Connecticut, USA
    Biol Psychiatry 61:545-50. 2007
    ..The effects of short- and long-term risperidone treatment on serum prolactin were assessed in children and adolescents with autism...
  65. ncbi request reprint Risperidone in children with autism and serious behavioral problems
    James T McCracken
    University of California, Los Angeles, USA
    N Engl J Med 347:314-21. 2002
    ..However, data on the safety and efficacy of atypical antipsychotic agents in children are limited...
  66. ncbi request reprint A prospective open trial of guanfacine in children with pervasive developmental disorders
    Lawrence Scahill
    Yale Child Study Center, P O Box 207900, New Haven, CT 06520, USA
    J Child Adolesc Psychopharmacol 16:589-98. 2006
    ..A common complaint for children with pervasive developmental disorder (PDD) is hyperactivity. The purpose of this pilot study was to gather preliminary information on the efficacy of guanfacine in children with PDD and hyperactivity...
  67. ncbi request reprint Methylphenidate an effective treatment for ADHD?
    Christopher J McDougle
    J Autism Dev Disord 34:593-4. 2004
  68. ncbi request reprint Research knowledge among parents of children participating in a randomized clinical trial
    Benedetto Vitiello
    Child and Adolescent Treatment and Preventive Intervention Research Branch, National Institute of Mental Health, Bethesda, MD 20892 9633, USA
    J Am Acad Child Adolesc Psychiatry 44:145-9. 2005
    ..Parental permission is required for child research, but parents' understanding of research aims and procedures has not been well documented. Parental research knowledge was assessed during a clinical trial in autism...
  69. ncbi request reprint Acute and long-term safety and tolerability of risperidone in children with autism
    Michael G Aman
    The Nisonger Center, Ohio State University, Columbus, Ohio 43210 1296, USA
    J Child Adolesc Psychopharmacol 15:869-84. 2005
    ..Most AEs were mild to moderate and failed to interfere with therapeutic changes; there were no unanticipated AEs. The side effects of most concern were somnolence and weight gain...
  70. ncbi request reprint Obsessive-compulsive disorder (OCD)
    Christopher J McDougle
    J Autism Dev Disord 35:685-6. 2005
  71. ncbi request reprint Increased cerebrospinal fluid corticotropin-releasing factor concentrations during tryptophan depletion in healthy adults
    Audrey R Tyrka
    Department of Psychiatry and Human Behavior, Brown Medical School, Providence, Rhode Island, USA
    Biol Psychiatry 56:531-4. 2004
    ..This study examined the effect of tryptophan depletion, which acutely reduces brain serotonin concentrations, on serial cerebrospinal fluid concentrations of corticotropin-releasing factor in healthy humans...
  72. ncbi request reprint Priapism associated with trazodone in an adolescent with autism
    Deborah L Kem
    J Am Acad Child Adolesc Psychiatry 41:758. 2002
  73. ncbi request reprint Validity of the autism diagnostic interview-revised
    Luc Lecavalier
    Nisonger Center, The Ohio State University, Columbus, USA
    Am J Ment Retard 111:199-215. 2006
    ..They indicated some similarities between constructs, but also that the ADI-R measures autism in a unique fashion...
  74. ncbi request reprint Pediatric psychopharmacology: mood, anxiety and disruptive behavior/pervasive developmental disorders
    Christopher J McDougle
    Psychopharmacology (Berl) 191:1-3. 2007
  75. ncbi request reprint Cerebrospinal fluid interleukin-6 in obsessive-compulsive disorder and trichotillomania
    Linda L Carpenter
    Mood Disorders Research Program, Butler Hospital, and Department of Psychiatry and Human Behavior, Brown Medical School, Butler Hospital, 345 Blackstone Boulevard, Providence, RI 02906, USA
    Psychiatry Res 112:257-62. 2002
    ..3+/-0.8 pg/ml) and their matched controls (n=14) (1.9+/-0.5 pg/ml). These findings fail to support speculation that ongoing immune activation may be causally involved in the pathogenesis of OCD or trichotillomania...
  76. pmc Developmental disabilities modification of the Children's Global Assessment Scale
    Ann Wagner
    National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    Biol Psychiatry 61:504-11. 2007
    ..To measure global functioning in treatment studies, the Children's Global Assessment Scale was modified and psychometric properties of the revised version (DD-CGAS) were assessed in children with PDD...

Research Grants8

  1. RUPP-PI
    Christopher McDougle; Fiscal Year: 2006
    ..The RUPP-PI at Indiana University is also prepared to participate in treatment studies involving children and adolescents with other psychiatric disorders. ..
  2. Novel Pharmacological Strategies in Autism
    Christopher McDougle; Fiscal Year: 2009
    ..Phase II (following 6 months of aripiprazole monotherapy). ..
  3. 1/4-RUPP Autism Network: Guanfacine for the Treatment of Hyperactivity in PDD
    Christopher J McDougle; Fiscal Year: 2010
    ..Methylphenidate or placebo will be added for children who show partial benefit to guanfacine. ..