WILLIAM JOSEPH MCBRIDE

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. ncbi request reprint Cocaine is self-administered into the shell but not the core of the nucleus accumbens of Wistar rats
    Zachary A Rodd-Henricks
    Institute of Psychiatric Research and Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46202 4887, USA
    J Pharmacol Exp Ther 303:1216-26. 2002
  2. ncbi request reprint Adolescent alcohol drinking and its long-range consequences. Studies with animal models
    William J McBride
    Indiana University School of Medicine, Institute of Psychiatric Research, Indianapolis, Indiana 46202 4887, USA
    Recent Dev Alcohol 17:123-42. 2005
  3. ncbi request reprint Daily patterns of ethanol drinking in peri-adolescent and adult alcohol-preferring (P) rats
    Richard L Bell
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Pharmacol Biochem Behav 83:35-46. 2006
  4. pmc Effects of short deprivation and re-exposure intervals on the ethanol drinking behavior of selectively bred high alcohol-consuming rats
    Richard L Bell
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Alcohol 42:407-16. 2008
  5. pmc Gene expression changes in the nucleus accumbens of alcohol-preferring rats following chronic ethanol consumption
    Richard L Bell
    Department of Psychiatry, Indiana University Purdue University at Indianapolis, Indianapolis, IN 46202, USA
    Pharmacol Biochem Behav 94:131-47. 2009
  6. doi request reprint Changes in gene expression within the extended amygdala following binge-like alcohol drinking by adolescent alcohol-preferring (P) rats
    William J McBride
    Institute of Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, Indiana University Purdue University at Indianapolis, Indianapolis, IN 46202, United States Electronic address
    Pharmacol Biochem Behav 117:52-60. 2014
  7. pmc Gene expression within the extended amygdala of 5 pairs of rat lines selectively bred for high or low ethanol consumption
    William J McBride
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, 791 Union Drive, Indianapolis, IN 46202 4887, USA Electronic address
    Alcohol 47:517-29. 2013
  8. pmc Changes in gene expression within the ventral tegmental area following repeated excessive binge-like alcohol drinking by alcohol-preferring (P) rats
    William J McBride
    Institute of Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, Indiana University Purdue University at Indianapolis, Indianapolis, IN 46202, USA
    Alcohol 47:367-80. 2013
  9. pmc Gene expression in the ventral tegmental area of 5 pairs of rat lines selectively bred for high or low ethanol consumption
    William J McBride
    Institute of Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202 4887, USA
    Pharmacol Biochem Behav 102:275-85. 2012
  10. pmc Changes in gene expression in regions of the extended amygdala of alcohol-preferring rats after binge-like alcohol drinking
    William J McBride
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University Purdue University at Indianapolis, Indianapolis, 46202 4887, USA
    Alcohol 44:171-83. 2010

Research Grants

  1. Neurobiology of high alcohol-seeking behavior
    WILLIAM JOSEPH MCBRIDE; Fiscal Year: 2010
  2. NEUROBIOLOGY OF HIGH ALCOHOL SEEKING BEHAVIOR
    William McBride; Fiscal Year: 2004
  3. Neurobiology of high alcohol-seeking behavior
    William McBride; Fiscal Year: 2007
  4. TRAINING GRANT ON GENETIC ASPECTS OF ALCOHOLISM
    William McBride; Fiscal Year: 2007
  5. CNS SITES FOR THE REWARDING ACTIONS OF ALCOHOL
    William McBride; Fiscal Year: 2009
  6. Neurobiology of high alcohol-seeking behavior
    William McBride; Fiscal Year: 2009
  7. NEUROBIOLOGICAL FACTORS IN ADOLESCENT ALCOHOL DRINKING
    William McBride; Fiscal Year: 2009
  8. Involvement of Aldehydes in Alcohol Addiction
    William McBride; Fiscal Year: 2009
  9. Excessive alcohol drinking and CNS regional changes in gene expression
    William McBride; Fiscal Year: 2007
  10. CNS SITES FOR THE REWARDING ACTIONS OF ALCOHOL
    William McBride; Fiscal Year: 2007

Detail Information

Publications71

  1. ncbi request reprint Cocaine is self-administered into the shell but not the core of the nucleus accumbens of Wistar rats
    Zachary A Rodd-Henricks
    Institute of Psychiatric Research and Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46202 4887, USA
    J Pharmacol Exp Ther 303:1216-26. 2002
    ..These findings suggest that the AcbSh is a neuroanatomical substrate for the reinforcing effects of cocaine and that activation of D2-like receptors is involved...
  2. ncbi request reprint Adolescent alcohol drinking and its long-range consequences. Studies with animal models
    William J McBride
    Indiana University School of Medicine, Institute of Psychiatric Research, Indianapolis, Indiana 46202 4887, USA
    Recent Dev Alcohol 17:123-42. 2005
    ..With suitable animal models, a better understanding of the mechanisms underlying adolescent alcohol drinking and its long-range consequences can be attained...
  3. ncbi request reprint Daily patterns of ethanol drinking in peri-adolescent and adult alcohol-preferring (P) rats
    Richard L Bell
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Pharmacol Biochem Behav 83:35-46. 2006
    ..This suggests that the effectiveness of treatments for reducing excessive alcohol intake may vary depending upon the age and/or sex of the subjects being tested...
  4. pmc Effects of short deprivation and re-exposure intervals on the ethanol drinking behavior of selectively bred high alcohol-consuming rats
    Richard L Bell
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Alcohol 42:407-16. 2008
    ..These findings suggest that (a) an ADE may be observed with short ethanol deprivation and re-exposure intervals in HAD rats, and (b) the genetic make-up of the P and HAD rats influences the expression of this ADE...
  5. pmc Gene expression changes in the nucleus accumbens of alcohol-preferring rats following chronic ethanol consumption
    Richard L Bell
    Department of Psychiatry, Indiana University Purdue University at Indianapolis, Indianapolis, IN 46202, USA
    Pharmacol Biochem Behav 94:131-47. 2009
    ..Conversely, chronic MSA drinking, with its associated protracted withdrawal periods, results in genomic changes that may be masked by tight regulation of these genes following repeated experiences of ethanol withdrawal...
  6. doi request reprint Changes in gene expression within the extended amygdala following binge-like alcohol drinking by adolescent alcohol-preferring (P) rats
    William J McBride
    Institute of Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, Indiana University Purdue University at Indianapolis, Indianapolis, IN 46202, United States Electronic address
    Pharmacol Biochem Behav 117:52-60. 2014
    ....
  7. pmc Gene expression within the extended amygdala of 5 pairs of rat lines selectively bred for high or low ethanol consumption
    William J McBride
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, 791 Union Drive, Indianapolis, IN 46202 4887, USA Electronic address
    Alcohol 47:517-29. 2013
    ....
  8. pmc Changes in gene expression within the ventral tegmental area following repeated excessive binge-like alcohol drinking by alcohol-preferring (P) rats
    William J McBride
    Institute of Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, Indiana University Purdue University at Indianapolis, Indianapolis, IN 46202, USA
    Alcohol 47:367-80. 2013
    ..Overall, the results of this study indicate that the repeated excessive binge-like alcohol drinking can change the expression of genes that may alter neuronal function in several ways, some of which may be deleterious. ..
  9. pmc Gene expression in the ventral tegmental area of 5 pairs of rat lines selectively bred for high or low ethanol consumption
    William J McBride
    Institute of Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202 4887, USA
    Pharmacol Biochem Behav 102:275-85. 2012
    ....
  10. pmc Changes in gene expression in regions of the extended amygdala of alcohol-preferring rats after binge-like alcohol drinking
    William J McBride
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University Purdue University at Indianapolis, Indianapolis, 46202 4887, USA
    Alcohol 44:171-83. 2010
    ....
  11. ncbi request reprint Central nervous system mechanisms in alcohol relapse
    W J McBride
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202 4887, USA
    Alcohol Clin Exp Res 26:280-6. 2002
    ....
  12. ncbi request reprint Alcohol effects on central nervous system gene expression in genetic animal models
    William J McBride
    Indiana University School of Medicine, Indianapolis, Indiana, USA
    Alcohol Clin Exp Res 29:167-75. 2005
    ..Hashimoto and Kristine M. Wiren...
  13. ncbi request reprint Central nucleus of the amygdala and the effects of alcohol and alcohol-drinking behavior in rodents
    William J McBride
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, 791 Union Drive, Indianapolis, IN 46202 4887, USA
    Pharmacol Biochem Behav 71:509-15. 2002
    ..Overall, the findings from the various studies support a role for the CeA in mediating the stimulating actions of alcohol in mice and regulating alcohol-drinking behavior in mice and rats...
  14. ncbi request reprint Serotonin-3 receptors in the actions of alcohol, alcohol reinforcement, and alcoholism
    William J McBride
    Indiana University School of Medicine, Indianapolis, Indiana, USA
    Alcohol Clin Exp Res 28:257-67. 2004
    ..Rodd and James M. Murphy; and (4) Ondansetron as a treatment for "biological" alcoholism, by John D. Roache and Bankole A. Johnson...
  15. pmc Differential effects of ethanol in the nucleus accumbens shell of alcohol-preferring (P), alcohol-non-preferring (NP) and Wistar rats: a proteomics study
    William J McBride
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, United States
    Pharmacol Biochem Behav 92:304-13. 2009
    ....
  16. ncbi request reprint Involvement of acetaldehyde in alcohol addiction
    William J McBride
    Indiana University School of Medicine, Indianapolis, Indiana, USA
    Alcohol Clin Exp Res 26:114-9. 2002
    ..Smith; (3) The reinforcing actions of acetaldehyde in the ventral tegmental area, by Zachary A. Rodd-Henricks; and (4) Salsolinol and alcohol addiction, by William J. McBride...
  17. ncbi request reprint Effects of ethanol drinking on central nervous system functional activity of alcohol-preferring rats
    Helen J K Sable
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Alcohol 35:129-35. 2005
    ..Overall, the results of this study indicate that 24-h ethanol-drinking experience has little effect on CNS functional neuronal activity in P rats...
  18. doi request reprint Effects of alcohol and saccharin deprivations on concurrent ethanol and saccharin operant self-administration by alcohol-preferring (P) rats
    Jamie E Toalston
    Department of Psychology, Purdue School of Science, Indiana University Purdue University at Indianapolis, Indianapolis, IN 46202, USA
    Alcohol 42:277-84. 2008
    ..Depriving P rats of both ethanol and SACC had the most pronounced effect on the magnitude and duration of the ADE, suggesting that there may be some interactions between ethanol and SACC in their CNS reinforcing effects...
  19. pmc A single, moderate ethanol exposure alters extracellular dopamine levels and dopamine d receptor function in the nucleus accumbens of wistar rats
    Kelle M Franklin
    Department of Psychology, Purdue School of Science, IUPUI, Indianapolis, Indiana 46202, USA
    Alcohol Clin Exp Res 33:1721-30. 2009
    ..The objectives of the current study were to evaluate the effects of a single EtOH pretreatment and repeated EtOH pretreatments on DA neurotransmission and D(2) autoreceptor function in the NAc of Wistar rats...
  20. ncbi request reprint Effects of repeated daily treatments with a 5-HT3 receptor antagonist on dopamine neurotransmission and functional activity of 5-HT3 receptors within the nucleus accumbens of Wistar rats
    Wen Liu
    Institute of Psychiatric Research, 791 Union Dr, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202 4887, USA
    Pharmacol Biochem Behav 84:370-7. 2006
    ..Overall, the results suggest that repeated daily treatments with MDL decreased basal DA neurotransmission in the ACB and did not have a clear effect on functional activity of 5-HT3 receptors in the ACB...
  21. ncbi request reprint Microdialysis of dopamine in the nucleus accumbens of alcohol-preferring (P) rats during anticipation and operant self-administration of ethanol
    Roberto I Melendez
    Department of Psychology, Program in Psychobiology of Addictions, Purdue School of Science IUPUI, 402 N Blackford Street, Indianapolis, Indiana 46202 3275, USA
    Alcohol Clin Exp Res 26:318-25. 2002
    ..The study also explored the association between elevated locomotor activity and NAc dopamine efflux during operant self-administration of ethanol...
  22. ncbi request reprint Dopamine receptor regulation of ethanol intake and extracellular dopamine levels in the ventral pallidum of alcohol preferring (P) rats
    Roberto I Melendez
    Program in Psychobiology of Addictions, Department of Psychology, LD 124, Purdue School of Science, Indiana University Purdue University at Indianapolis, IUPUI, 402 N Blackford St, Indianapolis, IN 46202 3275, USA
    Drug Alcohol Depend 77:293-301. 2005
    ....
  23. pmc Activation of serotonin-3 receptors increases dopamine release within the ventral tegmental area of Wistar and alcohol-preferring (P) rats
    Wen Liu
    Institute of Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Alcohol 40:167-76. 2006
    ....
  24. ncbi request reprint Ethanol drinking experience attenuates (-)sulpiride-induced increases in extracellular dopamine levels in the nucleus accumbens of alcohol-preferring (P) rats
    Eric A Engleman
    Department of Psychology, Purdue School of Science, 402 N Blackford Street, IUPUI, Indianapolis, IN 46202 3275, USA
    Alcohol Clin Exp Res 27:424-31. 2003
    ....
  25. ncbi request reprint Involvement of GABA and cholinergic receptors in the nucleus accumbens on feedback control of somatodendritic dopamine release in the ventral tegmental area
    Shafiqur Rahman
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202 4887, USA
    J Neurochem 80:646-54. 2002
    ..Cholinergic interneurons may influence the negative feedback system by regulating terminal DA release within the ACB...
  26. ncbi request reprint Reduced neuropeptide Y mRNA expression in the central nucleus of amygdala of alcohol preferring (P) rats: its potential involvement in alcohol preference and anxiety
    Ryoji Suzuki
    Department of Anatomy and Cell Biology MS 5035, Indiana University School of Medicine, 635 North Barnhill Drive, Indianapolis, IN 46202 5120, USA
    Brain Res 1014:251-4. 2004
    ..This study suggests that reduced NPY gene expression in the CeA may contribute to differences in alcohol preference and other behavioral differences observed between P and NP rats...
  27. ncbi request reprint Effects of multiple alcohol deprivations on operant ethanol self-administration by high-alcohol-drinking replicate rat lines
    Scott M Oster
    Department of Psychology, Purdue School of Science, Indiana University Purdue University at Indianapolis, Indianapolis, IN 46202, USA
    Alcohol 38:155-64. 2006
    ....
  28. ncbi request reprint Local cerebral glucose utilization after relapse in ethanol drinking in alcohol-preferring (P) rats
    Daniel G Smith
    Program in Psychobiology of Addictions, Department of Psychology, Purdue School of Science, Indiana University Purdue University at Indianapolis, Indianapolis, IN 46202, USA
    Alcohol 27:115-26. 2002
    ....
  29. pmc Autonomic activation associated with ethanol self-administration in adult female P rats
    Richard L Bell
    Institute of Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Pharmacol Biochem Behav 91:223-32. 2008
    ..Therefore, this behavioral test may prove advantageous in screening pharmacotherapies for reducing craving and relapse, which are associated with cue-reactivity in abstinent alcoholics...
  30. pmc Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions
    Mark W Kimpel
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202 4887, USA
    Alcohol 41:95-132. 2007
    ..The many regional and overall gene expression differences between the iP and iNP rat lines may contribute to the divergent alcohol drinking phenotypes of these rats...
  31. doi request reprint In vivo time-course changes in ethanol levels sampled with subcutaneous microdialysis
    Eric A Engleman
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, IN 46220, USA
    Alcohol Clin Exp Res 32:435-42. 2008
    ..c. fluid would reflect blood EtOH concentrations. If this is the case, then s.c. microdialysis could allow a more detailed analysis of changes in in vivo levels of EtOH under different drinking paradigms...
  32. ncbi request reprint The alcohol-preferring P rat and animal models of excessive alcohol drinking
    Richard L Bell
    Department of Psychiatry, Indiana University School of Medicine, USA
    Addict Biol 11:270-88. 2006
    ....
  33. ncbi request reprint Innate differences in neuropeptide Y (NPY) mRNA expression in discrete brain regions between alcohol-preferring (P) and -nonpreferring (NP) rats: a significantly low level of NPY mRNA in dentate gyrus of the hippocampus and absence of NPY mRNA in the medi
    Bang H Hwang
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA
    Neuropeptides 38:359-68. 2004
    ..Our study suggests that lower NPY gene expression in the DG and MHb of P rats may be factors contributing to some of the phenotypic differences observed between the P and NP lines of rats...
  34. ncbi request reprint The reinforcing properties of salsolinol in the ventral tegmental area: evidence for regional heterogeneity and the involvement of serotonin and dopamine
    Zachary A Rodd
    Institute of Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46202 4887, USA
    Alcohol Clin Exp Res 32:230-9. 2008
    ..The current study examined SAL self-infusions into the VTA, and determined the involvement of dopamine neurons and 5-HT3 receptors in this process...
  35. pmc Differential effects of dopamine D2 and GABA(A) receptor antagonists on dopamine neurons between the anterior and posterior ventral tegmental area of female Wistar rats
    Zheng Ming Ding
    Indiana University School of Medicine, Institute of PsychiatricResearch, 791 Union Drive, Indianapolis, IN 46202 4887, USA
    Pharmacol Biochem Behav 92:404-12. 2009
    ....
  36. pmc The posterior ventral tegmental area mediates alcohol-seeking behavior in alcohol-preferring rats
    Sheketha R Hauser
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, IN, USA
    J Pharmacol Exp Ther 336:857-65. 2011
    ..Overall, the results suggest that the p-VTA is a neuroanatomical substrate mediating alcohol-seeking behavior and that activation of local DA neurons is involved...
  37. pmc Sensitization of ventral tegmental area dopamine neurons to the stimulating effects of ethanol
    Zheng Ming Ding
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, IN 46202 4887, USA
    Alcohol Clin Exp Res 33:1571-81. 2009
    ..The current study tested the hypothesis that local exposure of the p-VTA to ethanol would increase the sensitivity of dopamine (DA) neurons to the stimulating effects of ethanol...
  38. pmc Involvement of local serotonin-2A but not serotonin-1B receptors in the reinforcing effects of ethanol within the posterior ventral tegmental area of female Wistar rats
    Zheng Ming Ding
    Graduate Program in Medical Neuroscience, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Psychopharmacology (Berl) 204:381-90. 2009
    ..5-HT(1B) and 5-HT(2A) receptors are involved in the effects of 5-HT and ethanol on VTA dopamine neurons...
  39. pmc Effects of concurrent access to multiple ethanol concentrations and repeated deprivations on alcohol intake of high-alcohol-drinking (HAD) rats
    Zachary A Rodd
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicne, USA
    Addict Biol 14:152-64. 2009
    ..The results indicate that HAD rats exhibit 'loss-of-control' of alcohol drinking with repeated deprivations when multiple ethanol concentrations are available...
  40. pmc Acute ethanol effects on local cerebral glucose utilization in select central nervous system regions of adolescent alcohol-preferring (P) and alcohol-nonpreferring (NP) rats
    Wendy N Strother
    Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202 4887, USA
    Alcohol Clin Exp Res 32:1875-83. 2008
    ..The 2-[(14)C]deoxyglucose (2-DG) technique allows for the in vivo quantification of local cerebral glucose utilization (LCGU) as a measure of functional neuronal activity...
  41. pmc Ethanol is self-administered into the nucleus accumbens shell, but not the core: evidence of genetic sensitivity
    Eric A Engleman
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indiana University Purdue University at Indianapolis, 791 Union Drive, Indianapolis, IN 46202 4887, USA
    Alcohol Clin Exp Res 33:2162-71. 2009
    ....
  42. doi request reprint Serotonin-3 receptors in the posterior ventral tegmental area regulate ethanol self-administration of alcohol-preferring (P) rats
    Zachary A Rodd
    Department of Psychiatry, Institute of Psychiatric Research, Indiana School of Medicine, Indianapolis, USA
    Alcohol 44:245-55. 2010
    ..In addition, chronic operant ethanol self-administration and/or repeated treatments with a 5-HT(3) receptor antagonist may alter neuronal circuitry within the posterior VTA...
  43. ncbi request reprint Extracellular dopamine levels are lower in the medial prefrontal cortex of alcohol-preferring rats compared to Wistar rats
    Eric A Engleman
    Institute of Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, Indiana University Purdue University Indianapolis, Indianapolis, IN, USA
    Alcohol 38:5-12. 2006
    ..The lack of effect of systemic EtOH administration on extracellular DA levels in the MPF suggests that unlike the mesolimbic DA system, the mesocortical DA system is not responsive to acute EtOH administration...
  44. ncbi request reprint The metabotropic glutamate 2/3 receptor agonist LY404039 reduces alcohol-seeking but not alcohol self-administration in alcohol-preferring (P) rats
    Zachary A Rodd
    Department of Psychiatry, Indiana University School of Medicine, Institute of Psychiatric Research, Indianapolis, 46202 4887, USA
    Behav Brain Res 171:207-15. 2006
    ..The results of this study demonstrate that activating mGlu2/3 receptors inhibits the expression of alcohol seeking and relapse behavior without altering alcohol self-administration behavior...
  45. ncbi request reprint Comparison of intracranial self-administration of ethanol within the posterior ventral tegmental area between alcohol-preferring and Wistar rats
    Zachary A Rodd
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46202 4887, USA
    Alcohol Clin Exp Res 28:1212-9. 2004
    ....
  46. ncbi request reprint Intracranial self-administration of ethanol within the ventral tegmental area of male Wistar rats: evidence for involvement of dopamine neurons
    Zachary A Rodd
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Neurosci 24:1050-7. 2004
    ..The results of this study indicate that EtOH is reinforcing within the posterior VTA of male Wistar rats and suggest that activation of VTA DA neurons is involved in this process...
  47. pmc Innate differences in protein expression in the nucleus accumbens and hippocampus of inbred alcohol-preferring and -nonpreferring rats
    Frank A Witzmann
    Department of Cellular and Integrative Physiology, Biotechnology Research and Training Center, Indiana University School of Medicine, 1345 W 16th Street, Indianapolis, IN 46202, USA
    Proteomics 3:1335-44. 2003
    ....
  48. ncbi request reprint Effects of repeated alcohol deprivations on operant ethanol self-administration by alcohol-preferring (P) rats
    Zachary A Rodd
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Neuropsychopharmacology 28:1614-21. 2003
    ..The results suggest that repeated cycles of alcohol deprivation and alcohol access increased the reinforcing effects of ETOH in the P rats...
  49. ncbi request reprint Effects of concurrent access to a single concentration or multiple concentrations of ethanol on the intake of ethanol by male and female periadolescent alcohol-preferring (P) rats
    Richard L Bell
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis 46202, USA
    Alcohol 29:137-48. 2003
    ..These findings suggest to us that innate genetically influenced mechanisms promoting high ethanol intake are present at this stage of development...
  50. ncbi request reprint Alcohol stimulates the release of dopamine in the ventral pallidum but not in the globus pallidus: a dual-probe microdialysis study
    Roberto I Melendez
    Department of Psychology, Program in Psychobiology of Addictions, Purdue School of Science, Indiana University Purdue University at Indianapolis, 402 N Blackford Street, Indianapolis, IN 46202, USA
    Neuropsychopharmacology 28:939-46. 2003
    ..The data suggest that the mesopallidal, mesoaccumbens, and nigrostriatal dopamine systems are more sensitive to the effects of ethanol than the nigropallidal dopamine system...
  51. ncbi request reprint Regional CNS densities of serotonin 1A and dopamine D2 receptors in periadolescent alcohol-preferring P and alcohol-nonpreferring NP rat pups
    Wendy N Strother
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University Medical Center, Indiana University School of Medicine, 791 Union Drive, Indianapolis, IN 46202 4887, USA
    Pharmacol Biochem Behav 74:335-42. 2003
    ....
  52. ncbi request reprint Effects of serotonin-3 receptor antagonists on the intracranial self-administration of ethanol within the ventral tegmental area of Wistar rats
    Zachary A Rodd-Henricks
    Department of Psychiatry, Institute of Psychiatric Research, Indiana School of Medicine, 791 Union Drive, Indianapolis, IN 46202 4887, USA
    Psychopharmacology (Berl) 165:252-9. 2003
    ....
  53. ncbi request reprint Effects of ethanol exposure on subsequent acquisition and extinction of ethanol self-administration and expression of alcohol-seeking behavior in adult alcohol-preferring (P) rats: II. Adult exposure
    Zachary A Rodd-Henricks
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis 46202 4887, USA
    Alcohol Clin Exp Res 26:1642-52. 2002
    ..The objective of the present study was to determine if EtOH consumption during adulthood produced similar effects on subsequent operant behaviors...
  54. ncbi request reprint Heart rate and motor-activating effects of orally self-administered ethanol in alcohol-preferring (P) rats
    Richard L Bell
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, 791 Union Drive, Indianapolis, IN 46202 4887, USA
    Alcohol Clin Exp Res 26:1162-70. 2002
    ..This study examined changes in heart rate (HR) and motor activity before and during limited-access to ethanol, saccharin, or water in adult male alcohol-preferring (P) rats...
  55. ncbi request reprint Effect of housing conditions on sulpiride-induced increases in extracellular dopamine (DA) levels in the nucleus accumbens of alcohol-preferring (P) rats
    Eric A Engleman
    Department of Psychology, Institute of Psychiatric Research, Indiana University School of Medicine, Rm M115, 791 Union Drive, Indianapolis, IN 46202, USA
    Brain Res 1022:247-50. 2004
    ..Microdialysis in the NAC showed greater sulpiride-induced DA increases in the NAC of SH vs. DH rats, with no difference in basal levels. The data indicate that housing conditions can alter DA D(2) receptor function in the NAC...
  56. ncbi request reprint Regional heterogeneity for the intracranial self-administration of ethanol and acetaldehyde within the ventral tegmental area of alcohol-preferring (P) rats: involvement of dopamine and serotonin
    Zachary A Rodd
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University Purdue University at Indianapolis, Indianapolis, IN, USA
    Neuropsychopharmacology 30:330-8. 2005
    ..Furthermore, activation of 5-HT3 receptors within the posterior VTA is involved in the self-infusion of EtOH, but not ACD...
  57. ncbi request reprint Effects of concurrent access to a single concentration or multiple concentrations of ethanol on ethanol intake by periadolescent high-alcohol-drinking rats
    Richard L Bell
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Alcohol 33:107-15. 2004
    ....
  58. pmc Prolonged increase in the sensitivity of the posterior ventral tegmental area to the reinforcing effects of ethanol following repeated exposure to cycles of ethanol access and deprivation
    Zachary A Rodd
    Institute of Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, 46202, USA
    J Pharmacol Exp Ther 315:648-57. 2005
    ..Chronic alcohol drinking by P rats increased the reinforcing effects of ethanol within the posterior VTA, and repeated alcohol deprivations produced a further increase in these reinforcing effects of ethanol...
  59. ncbi request reprint Effects of acute administration of ethanol on cerebral glucose utilization in adult alcohol-preferring and alcohol-nonpreferring rats
    Wendy N Strother
    Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, IN 46202 4887, USA
    Alcohol 35:119-28. 2005
    ..These findings support the suggestion that certain central nervous system regions of P rats may be more sensitive than those of NP rats to the effects of low to intermediate doses of ethanol...
  60. pmc A proteomic survey of rat cerebral cortical synaptosomes
    Frank A Witzmann
    Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, 46202, USA
    Proteomics 5:2177-201. 2005
    ..The results also suggest that this experimental approach can be used to study the differential expression of multiple proteins involved in alterations of synaptic function...
  61. ncbi request reprint Phenotypic and genotypic characterization of the Indiana University rat lines selectively bred for high and low alcohol preference
    James M Murphy
    Department of Psychology, Purdue School of Science, Indiana University Purdue University Indianapolis, 46202 1375, USA
    Behav Genet 32:363-88. 2002
    ..The elucidation of the genotypes and phenotypes that result in excessive alcohol intake may lead to a better understanding of alcohol abuse and alcoholism and could guide strategies for potential treatment and prevention...
  62. ncbi request reprint Chronic ethanol drinking by alcohol-preferring rats increases the sensitivity of the posterior ventral tegmental area to the reinforcing effects of ethanol
    Zachary A Rodd
    Institute of Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, Indiana University, 791 Union Drive, Indianapolis, IN 46202, USA
    Alcohol Clin Exp Res 29:358-66. 2005
    ..The objective of this study was to test the hypothesis that chronic ethanol drinking increases the sensitivity of the posterior VTA to the reinforcing effects of ethanol...
  63. ncbi request reprint Dopamine and serotonin content in select brain regions of weanling and adult alcohol drinking rat lines
    Wendy N Strother
    Department of Psychiatry and Institute of Psychiatric Research, 791 Union Drive, Indianapolis, IN, 46202 4887, USA
    Pharmacol Biochem Behav 80:229-37. 2005
    ..These results confirm previous findings of an association between innate low DA content in select limbic regions and high alcohol drinking behavior...
  64. ncbi request reprint Intracranial self-administration of cocaine within the posterior ventral tegmental area of Wistar rats: evidence for involvement of serotonin-3 receptors and dopamine neurons
    Zachary A Rodd
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, 791 Union Drive, Indianapolis, IN 46202 4887, USA
    J Pharmacol Exp Ther 313:134-45. 2005
    ....
  65. ncbi request reprint Effects of long-term episodic access to ethanol on the expression of an alcohol deprivation effect in low alcohol-consuming rats
    Richard L Bell
    Indiana University School of Medicine, Department of Psychiatry, Institute of Psychiatric Research, 791 Union Drive, Indianapolis, IN 46202 4887, USA
    Alcohol Clin Exp Res 28:1867-74. 2004
    ..In addition, both P and HAD rats display an alcohol deprivation effect (ADE). This study was undertaken to test whether the NP, LAD-1, and LAD-2 lines of rats could display an ADE as well...
  66. ncbi request reprint Recent advances in animal models of alcohol craving and relapse
    Zachary A Rodd
    Institute of Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, 791 Union Drive, Indianapolis, IN 46202 4887, USA
    Pharmacol Biochem Behav 79:439-50. 2004
    ..Overall, the findings indicate substantial progress has been made in developing animal models of alcohol abuse, relapse and craving using these selectively bred rat lines, as well as outbred rats...
  67. ncbi request reprint The reinforcing effects of acetaldehyde in the posterior ventral tegmental area of alcohol-preferring rats
    Zachary A Rodd-Henricks
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, 791 Union Drive, Indianapolis, IN 46202 4887, USA
    Pharmacol Biochem Behav 72:55-64. 2002
    ..P rats maintained similar numbers of infusions and infusion patterns under both time-out schedules. Overall, the data indicate that ACD is a potent reinforcer within the posterior VTA of the P rat...
  68. pmc The reinforcing actions of a serotonin-3 receptor agonist within the ventral tegmental area: evidence for subregional and genetic differences and involvement of dopamine neurons
    Zachary A Rodd
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, 791 Union Drive, Indianapolis, IN 46202 4887, USA
    J Pharmacol Exp Ther 321:1003-12. 2007
    ..Furthermore, the data suggest that selective breeding for alcohol-preference results in the posterior VTA being more sensitive to the reinforcing effects of CPBG...
  69. ncbi request reprint Salsolinol produces reinforcing effects in the nucleus accumbens shell of alcohol-preferring (P) rats
    Zachary A Rodd
    Indiana University School of Medicine, Institute of Psychiatric Research, 791 Union Drive, Indianapolis, IN 46202 4887, USA
    Alcohol Clin Exp Res 27:440-9. 2003
    ....
  70. doi request reprint Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats
    Zachary A Rodd
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202 4887, United States
    Pharmacol Biochem Behav 89:481-98. 2008
    ..g., Cav2, Nrxn3, Gabrb2, Gad1, Homer1) and homeostasis (S100b, Prkca, Ftl1) categories. Overall, the results suggest that changes in gene expression in the ACB of iP rats are associated with the reinforcing effects of EtOH...
  71. ncbi request reprint Effects of ethanol exposure on subsequent acquisition and extinction of ethanol self-administration and expression of alcohol-seeking behavior in adult alcohol-preferring (P) rats: I. Periadolescent exposure
    Zachary A Rodd-Henricks
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis 46202 4887, USA
    Alcohol Clin Exp Res 26:1632-41. 2002
    ....

Research Grants56

  1. Neurobiology of high alcohol-seeking behavior
    WILLIAM JOSEPH MCBRIDE; Fiscal Year: 2010
    ....
  2. NEUROBIOLOGY OF HIGH ALCOHOL SEEKING BEHAVIOR
    William McBride; Fiscal Year: 2004
    ..The results of this project will provide fundamental information toward understanding the neurobiological mechanisms underlying high alcohol-seeking behavior. Such information would be important for developing pharmacotherapies. ..
  3. Neurobiology of high alcohol-seeking behavior
    William McBride; Fiscal Year: 2007
    ....
  4. TRAINING GRANT ON GENETIC ASPECTS OF ALCOHOLISM
    William McBride; Fiscal Year: 2007
    ..Identifying the genes that contribute to alcoholism, and understanding how these genes influence neuronal functions would greatly contribute toward understanding and treating alcoholism. ..
  5. CNS SITES FOR THE REWARDING ACTIONS OF ALCOHOL
    William McBride; Fiscal Year: 2009
    ..abstract_text> ..
  6. Neurobiology of high alcohol-seeking behavior
    William McBride; Fiscal Year: 2009
    ....
  7. NEUROBIOLOGICAL FACTORS IN ADOLESCENT ALCOHOL DRINKING
    William McBride; Fiscal Year: 2009
    ..Such information could be helpful in developing useful strategies for combating the major problem of adolescent alcohol drinking. ..
  8. Involvement of Aldehydes in Alcohol Addiction
    William McBride; Fiscal Year: 2009
    ..Understanding the contribution of ACD and THIQs to high alcohol drinking could lead to the development of novel pharmaco-therapies for the treatment of alcoholism and alcohol abuse ..
  9. Excessive alcohol drinking and CNS regional changes in gene expression
    William McBride; Fiscal Year: 2007
    ..Such information would be critically important for developing pharmacotherapeutic strategies to treat alcoholism and alcohol abuse. ..
  10. CNS SITES FOR THE REWARDING ACTIONS OF ALCOHOL
    William McBride; Fiscal Year: 2007
    ....
  11. CNS SITES FOR THE REWARDING ACTIONS OF ALCOHOL
    William McBride; Fiscal Year: 2004
    ....
  12. NEURAL BASIS OF THE ALCOHOL DEPRIVATION EFFECT
    William McBride; Fiscal Year: 1999
    ....
  13. NEUROBIOLOGY OF HIGH ALCOHOL SEEKING BEHAVIOR
    William McBride; Fiscal Year: 1999
    ..This knowledge could aid in the development of novel pharmacological therapies for the treatment of alcoholism. ..
  14. NEUROBIOLOGICAL FACTORS IN ADOLESCENT ALCOHOL DRINKING
    William McBride; Fiscal Year: 1999
    ..Information gained from these animal studies will hopefully provide greater insight into the causes and prevention of adolescent alcohol drinking. ..
  15. NEUROBIOLOGICAL FACTORS IN ADOLESCENT ALCOHOL DRINKING
    William McBride; Fiscal Year: 2004
    ....
  16. Involvement of Aldehydes in Alcohol Addiction
    William McBride; Fiscal Year: 2002
    ..Such results could provide valuable information on novel mechanisms underlying the addictive properties of alcohol and would provide a firm scientific foundation for future neurobiological studies. ..