K Mather

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. ncbi Endothelin limits insulin action in obese/insulin-resistant humans
    Amale Lteif
    Division of Endocrinology and Metabolism, Department of Medicine, Indiana University School of Medicine, CL459, 541 North Clinical Drive, Indianapolis, IN 46202, USA
    Diabetes 56:728-34. 2007
  2. ncbi Normalization of flow-mediated dilation to shear stress area under the curve eliminates the impact of variable hyperemic stimulus
    Jaume Padilla
    Kinesiology, Indiana University, Bloomington, IN, USA
    Cardiovasc Ultrasound 6:44. 2008
  3. ncbi Evidence for physiological coupling of insulin-mediated glucose metabolism and limb blood flow
    K Mather
    Division of Endocrinology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Am J Physiol Endocrinol Metab 279:E1264-70. 2000
  4. ncbi Role of endogenous ET-1 in the regulation of myocardial blood flow in lean and obese humans
    Kieren J Mather
    Division of Endocrinology and Metabolism, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Obesity (Silver Spring) 18:63-70. 2010
  5. ncbi Interactions between endothelin and nitric oxide in the regulation of vascular tone in obesity and diabetes
    Kieren J Mather
    Division of Endocrinology and Metabolism, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Diabetes 53:2060-6. 2004
  6. ncbi Insulin resistance as a therapeutic target for improved endothelial function: metformin
    Lori Brame
    Indiana University, Indianapolis, IN 46202, USA
    Curr Drug Targets Cardiovasc Haematol Disord 4:53-63. 2004
  7. ncbi Endothelin contributes to basal vascular tone and endothelial dysfunction in human obesity and type 2 diabetes
    Kieren J Mather
    Division of Endocrinology and Metabolism, Indiana University Purdue University Indianapolis School of Medicine, CL459, 541 North Clinical Drive, Indianapolis, IN 46202, USA
    Diabetes 51:3517-23. 2002
  8. ncbi Repeatability characteristics of simple indices of insulin resistance: implications for research applications
    K J Mather
    Indiana University School of Medicine, Division of Endocrinology and Metabolism, Indianapolis, Indiana 46250, USA
    J Clin Endocrinol Metab 86:5457-64. 2001
  9. ncbi Insulin action in the vasculature: physiology and pathophysiology
    K Mather
    Division of Endocrinology and Metabolism, Indiana University School of Medicine, Indianapolis, Ind, USA
    J Vasc Res 38:415-22. 2001
  10. ncbi Insulin resistance, metabolic syndrome and vascular diseases: update on mechanistic linkages
    Amale Lteif
    Indiana University School of Medicine, Indianapolis, Indiana, USA
    Can J Cardiol 20:66B-76B. 2004

Research Grants

  1. ROLE OF HEMODYNAMICS IN IN VIVO INSULIN RESISTANCE
    Kieren Mather; Fiscal Year: 2003
  2. PET Approach To Measuring Human Myocardial Metabolism
    Kieren Mather; Fiscal Year: 2006

Detail Information

Publications20

  1. ncbi Endothelin limits insulin action in obese/insulin-resistant humans
    Amale Lteif
    Division of Endocrinology and Metabolism, Department of Medicine, Indiana University School of Medicine, CL459, 541 North Clinical Drive, Indianapolis, IN 46202, USA
    Diabetes 56:728-34. 2007
    ..These findings suggest that increased endogenous endothelin action contributes to insulin resistance in skeletal muscle of obese humans, likely through both vascular and tissue effects...
  2. ncbi Normalization of flow-mediated dilation to shear stress area under the curve eliminates the impact of variable hyperemic stimulus
    Jaume Padilla
    Kinesiology, Indiana University, Bloomington, IN, USA
    Cardiovasc Ultrasound 6:44. 2008
    ..The present study was designed to further examine the efficacy of FMD normalization to shear stress in reducing measurement variability...
  3. ncbi Evidence for physiological coupling of insulin-mediated glucose metabolism and limb blood flow
    K Mather
    Division of Endocrinology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Am J Physiol Endocrinol Metab 279:E1264-70. 2000
    ..001). These findings support a physiological coupling of LBF and insulin-mediated glucose metabolism. The mechanism(s) linking substrate delivery and metabolism appears to be intact in insulin-resistant states...
  4. ncbi Role of endogenous ET-1 in the regulation of myocardial blood flow in lean and obese humans
    Kieren J Mather
    Division of Endocrinology and Metabolism, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Obesity (Silver Spring) 18:63-70. 2010
    ..These observations suggest that endothelin is an important contributor to the regulation of myocardial perfusion under resting conditions in healthy lean and obese humans, with increased contributions in proportion to increasing obesity...
  5. ncbi Interactions between endothelin and nitric oxide in the regulation of vascular tone in obesity and diabetes
    Kieren J Mather
    Division of Endocrinology and Metabolism, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Diabetes 53:2060-6. 2004
    ..In contrast, endothelin antagonism alone is insufficient to restore impaired NO bioavailability in diabetes...
  6. ncbi Insulin resistance as a therapeutic target for improved endothelial function: metformin
    Lori Brame
    Indiana University, Indianapolis, IN 46202, USA
    Curr Drug Targets Cardiovasc Haematol Disord 4:53-63. 2004
    ..Therapeutically targeting insulin resistance appears to be a viable route to improving endothelial function in clinical states of insulin resistance...
  7. ncbi Endothelin contributes to basal vascular tone and endothelial dysfunction in human obesity and type 2 diabetes
    Kieren J Mather
    Division of Endocrinology and Metabolism, Indiana University Purdue University Indianapolis School of Medicine, CL459, 541 North Clinical Drive, Indianapolis, IN 46202, USA
    Diabetes 51:3517-23. 2002
    ..04), suggesting a combined effect of ET(A) blockade to reduce constrictor tone and augment dilator tone. Endothelin seems to contribute to endothelial dysfunction and the regulation of vascular tone in human obesity and type 2 diabetes...
  8. ncbi Repeatability characteristics of simple indices of insulin resistance: implications for research applications
    K J Mather
    Indiana University School of Medicine, Division of Endocrinology and Metabolism, Indianapolis, Indiana 46250, USA
    J Clin Endocrinol Metab 86:5457-64. 2001
    ..This helps explain their excellent correlations with formal measures both at baseline and with changes in insulin sensitivity and supports their broader application in clinical research...
  9. ncbi Insulin action in the vasculature: physiology and pathophysiology
    K Mather
    Division of Endocrinology and Metabolism, Indiana University School of Medicine, Indianapolis, Ind, USA
    J Vasc Res 38:415-22. 2001
    ..Improving insulin sensitivity with insulin sensitizers such as rosiglitazone may represent an important advance in our ability to improve vascular dysfunction in diabetes...
  10. ncbi Insulin resistance, metabolic syndrome and vascular diseases: update on mechanistic linkages
    Amale Lteif
    Indiana University School of Medicine, Indianapolis, Indiana, USA
    Can J Cardiol 20:66B-76B. 2004
    ..Progress along these novel lines of investigation will continue to expand the understanding of the mechanisms linking insulin resistance, the metabolic syndrome and vascular disease...
  11. ncbi Weight loss and endothelial function in obesity
    Kieren J Mather
    Diabetes Care 26:1927-8. 2003
  12. ncbi No impairment of endothelial function or insulin sensitivity with 4 weeks of the HIV protease inhibitors atazanavir or lopinavir-ritonavir in healthy subjects without HIV infection: a placebo-controlled trial
    Michael P Dube
    Division of Infectious Diseases, Department of Medicine, Indiana University School of Medicine, Indianapolis, USA
    Clin Infect Dis 47:567-74. 2008
    ..Some PIs, such as indinavir, directly induce endothelial dysfunction, an effect that may mediate that portion of the increase in cardiovascular events that is not attributable to dyslipidemia...
  13. ncbi Interactions of endothelin and insulin: expanding parameters of insulin resistance
    Andrew B Strawbridge
    Division of Endocrinology and Metabolism, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Curr Diabetes Rev 2:317-27. 2006
    ..The evidence implicating endothelin in insulin resistance and its associated vascular and metabolic abnormalities is reviewed...
  14. ncbi Adiponectin, change in adiponectin, and progression to diabetes in the Diabetes Prevention Program
    Kieren J Mather
    Division of Endocrinology and Metabolism, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Diabetes 57:980-6. 2008
    ..To determine whether baseline adiponectin levels or intervention-associated change in adiponectin levels were independently associated with progression to diabetes in the Diabetes Prevention Program (DPP)...
  15. ncbi Insulin and endothelin in the acute regulation of adiponectin in vivo in humans
    Lori A Brame
    Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Obes Res 13:582-8. 2005
    ..ET receptor antagonism with BQ123 did not modulate this effect, suggesting that endogenous ET does not have a role in modifying the acute effects of insulin on adiponectin production and/or disposition...
  16. ncbi Role of amylin in insulin secretion and action in humans: antagonist studies across the spectrum of insulin sensitivity
    Kieren J Mather
    Indiana University Medical Center, Indianapolis, IN 46202, USA
    Diabetes Metab Res Rev 18:118-26. 2002
    ..These observations provide the first human evidence that amylin plays a role in the modulation of insulin secretion...
  17. ncbi Diabetes and heart disease an evidence-driven guide to risk factors management in diabetes
    Amale A Lteif
    Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Cardiol Rev 11:262-74. 2003
    ..Finally, lifestyle changes and other cardiovascular therapies aimed at preventing heart disease may also prevent or delay the development of diabetes...
  18. ncbi Improvement in HIV-related endothelial dysfunction using the anti-inflammatory agent salsalate: a pilot study
    Samir K Gupta
    Indiana University School of Medicine, Indianapolis, Indiana, USA
    AIDS 22:653-5. 2008
    ..However, hepatotoxicity occurred frequently. Research using alternative agents is warranted to examine the role of inflammation in HIV-related cardiovascular disease...
  19. ncbi Extension of type 2 diabetes genome-wide association scan results in the diabetes prevention program
    Allan F Moore
    Center for Human Genetic Research, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
    Diabetes 57:2503-10. 2008
    ....
  20. ncbi Proteinuria and endothelial dysfunction in stable HIV-infected patients. A pilot study
    Samir K Gupta
    J Acquir Immune Defic Syndr 45:596-8. 2007

Research Grants2

  1. ROLE OF HEMODYNAMICS IN IN VIVO INSULIN RESISTANCE
    Kieren Mather; Fiscal Year: 2003
    ..If the data confirm our hypothesis, treatment of IR patients with ET1 antagonists may be a rational and beneficial approach to reducing the dreaded cardiovascular outcomes associated with IR and type 2 diabetes. ..
  2. PET Approach To Measuring Human Myocardial Metabolism
    Kieren Mather; Fiscal Year: 2006
    ....