ANNA L MALKOVA
Affiliation: Indiana University
- Break-induced replication is highly inaccurateAngela Deem
Department of Biology, School of Science, IUPUI, Indianapolis, Indiana, United States of America
PLoS Biol 9:e1000594. 2011..We further postulate that activation of BIR in eukaryotic cells may significantly contribute to accumulation of mutations that fuel cancer and evolution...
- Migrating bubble during break-induced replication drives conservative DNA synthesisNatalie Saini
School of Biology and Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
Nature 502:389-92. 2013..We propose that the BIR mode of synthesis presents a powerful mechanism that can initiate bursts of genetic instability in eukaryotes, including humans. ..
- Break-induced replication: functions and molecular mechanismAnna Malkova
Department of Biology, School of Science, IUPUI, Indianapolis, IN 46202, USA
Curr Opin Genet Dev 23:271-9. 2013..These features make BIR a likely pathway to promote bursts of genetic changes that fuel cancer progression and evolution. ..
- Mutations arising during repair of chromosome breaksAnna Malkova
Department of Biology, School of Science, IUPUI, Indianapolis, Indiana 46202 5132, USA
Annu Rev Genet 46:455-73. 2012..Overall, homologous recombination, which is traditionally considered a safe pathway of DSB repair, is an important source of mutagenesis that may contribute to human disease and evolution...