ANNA L MALKOVA

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. pmc Break-induced replication is highly inaccurate
    Angela Deem
    Department of Biology, School of Science, IUPUI, Indianapolis, Indiana, United States of America
    PLoS Biol 9:e1000594. 2011
  2. pmc Migrating bubble during break-induced replication drives conservative DNA synthesis
    Natalie Saini
    School of Biology and Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
    Nature 502:389-92. 2013
  3. ncbi request reprint Break-induced replication: functions and molecular mechanism
    Anna Malkova
    Department of Biology, School of Science, IUPUI, Indianapolis, IN 46202, USA
    Curr Opin Genet Dev 23:271-9. 2013
  4. doi request reprint Mutations arising during repair of chromosome breaks
    Anna Malkova
    Department of Biology, School of Science, IUPUI, Indianapolis, Indiana 46202 5132, USA
    Annu Rev Genet 46:455-73. 2012

Collaborators

  • Andrei Chabes
  • Angela Deem
  • Natalie Saini
  • Grzegorz Ira
  • Rajula Elango
  • Kirill S Lobachev
  • James E Haber
  • Sreejith Ramakrishnan
  • Sandeep Ayyar
  • Yu Zhang
  • Andrea Keszthelyi
  • Ruchi Mathur
  • Tiffany Blackgrove
  • Barbara Coffey
  • Alexandra Vayl

Detail Information

Publications4

  1. pmc Break-induced replication is highly inaccurate
    Angela Deem
    Department of Biology, School of Science, IUPUI, Indianapolis, Indiana, United States of America
    PLoS Biol 9:e1000594. 2011
    ..We further postulate that activation of BIR in eukaryotic cells may significantly contribute to accumulation of mutations that fuel cancer and evolution...
  2. pmc Migrating bubble during break-induced replication drives conservative DNA synthesis
    Natalie Saini
    School of Biology and Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
    Nature 502:389-92. 2013
    ..We propose that the BIR mode of synthesis presents a powerful mechanism that can initiate bursts of genetic instability in eukaryotes, including humans. ..
  3. ncbi request reprint Break-induced replication: functions and molecular mechanism
    Anna Malkova
    Department of Biology, School of Science, IUPUI, Indianapolis, IN 46202, USA
    Curr Opin Genet Dev 23:271-9. 2013
    ..These features make BIR a likely pathway to promote bursts of genetic changes that fuel cancer progression and evolution. ..
  4. doi request reprint Mutations arising during repair of chromosome breaks
    Anna Malkova
    Department of Biology, School of Science, IUPUI, Indianapolis, Indiana 46202 5132, USA
    Annu Rev Genet 46:455-73. 2012
    ..Overall, homologous recombination, which is traditionally considered a safe pathway of DSB repair, is an important source of mutagenesis that may contribute to human disease and evolution...

Research Grants2

  1. Amplification of Risk Caused by Mis-Routing of DNA Double-Strand Break Repair
    Anna Malkova; Fiscal Year: 2009
    ..Because genetic aberrations are a hallmark of cancer cells, this research will further our understanding of the etiology of some cancers. ..
  2. Amplification of Risk Caused by Mis-Routing of DNA Double-Strand Break Repair
    ANNA L MALKOVA; Fiscal Year: 2010
    ..Because genetic aberrations are a hallmark of cancer cells, this research will further our understanding of the etiology of some cancers. ..