P J Loehrer

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. ncbi request reprint Phase II study of gemcitabine plus docetaxel in advanced pancreatic cancer: a Hoosier Oncology Group study
    Bryan P Schneider
    Division of Hematology Oncology, Indiana University Medical Center and Walther Cancer Institute, Indianapolis, IN 46202, USA
    Oncology 65:218-23. 2003
  2. doi request reprint Clinical management of thymoma patients
    Erin M Casey
    Indiana University School of Medicine, 535 Barnhill Dr RT 473, Indianapolis, IN 46202, USA
    Hematol Oncol Clin North Am 22:457-73. 2008
  3. pmc Gemcitabine alone versus gemcitabine plus radiotherapy in patients with locally advanced pancreatic cancer: an Eastern Cooperative Oncology Group trial
    Patrick J Loehrer
    Indiana University Melvin and Bren Simon Cancer Center, 980 West Walnut St, Suite C528, Indianapolis, IN 46202, USA
    J Clin Oncol 29:4105-12. 2011
  4. ncbi request reprint Octreotide alone or with prednisone in patients with advanced thymoma and thymic carcinoma: an Eastern Cooperative Oncology Group Phase II Trial
    Patrick J Loehrer
    Indiana University Medical Center, Indianapolis, IN 46202, USA
    J Clin Oncol 22:293-9. 2004
  5. ncbi request reprint Combined etoposide, ifosfamide, and cisplatin in the treatment of patients with advanced thymoma and thymic carcinoma: an intergroup trial
    P J Loehrer
    Department of Medicine, Indiana University School of Medicine and the Walther Cancer Institute, Indianapolis, Indiana, USA
    Cancer 91:2010-5. 2001
  6. ncbi request reprint Current approaches to the treatment of thymoma
    P J Loehrer
    Indiana University Medical Center, The Walther Cancer Institute, Indianapolis 46202 5289, USA
    Ann Med 31:73-9. 1999
  7. ncbi request reprint Thymic malignancies
    P J Loehrer
    Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Cancer Treat Res 105:277-302. 2001
  8. ncbi request reprint Randomized comparison of cisplatin and etoposide and either bleomycin or ifosfamide in treatment of advanced disseminated germ cell tumors: an Eastern Cooperative Oncology Group, Southwest Oncology Group, and Cancer and Leukemia Group B Study
    C R Nichols
    Indiana University Medical Center, Indianapolis, USA
    J Clin Oncol 16:1287-93. 1998
  9. ncbi request reprint Vinblastine plus ifosfamide plus cisplatin as initial salvage therapy in recurrent germ cell tumor
    P J Loehrer
    Indiana University Medical Center, Indianapolis, USA
    J Clin Oncol 16:2500-4. 1998
  10. ncbi request reprint Mediastinal yolk sac tumor. The Indiana University experience, 1976 to 1988
    S Saxman
    Department of Medicine, Indiana University School of Medicine, Indianapolis
    J Thorac Cardiovasc Surg 102:913-6. 1991

Research Grants

  1. EASTERN COOPERATIVE ONCOLOGY GROUP
    Patrick Loehrer; Fiscal Year: 2004
  2. EASTERN COOPERATIVE ONCOLOGY GROUP
    Patrick Loehrer; Fiscal Year: 2007

Detail Information

Publications40

  1. ncbi request reprint Phase II study of gemcitabine plus docetaxel in advanced pancreatic cancer: a Hoosier Oncology Group study
    Bryan P Schneider
    Division of Hematology Oncology, Indiana University Medical Center and Walther Cancer Institute, Indianapolis, IN 46202, USA
    Oncology 65:218-23. 2003
    ..To determine the response rate, duration of response and survival with weekly gemcitabine plus docetaxel in metastatic or unresectable pancreatic cancer...
  2. doi request reprint Clinical management of thymoma patients
    Erin M Casey
    Indiana University School of Medicine, 535 Barnhill Dr RT 473, Indianapolis, IN 46202, USA
    Hematol Oncol Clin North Am 22:457-73. 2008
    ..Relapse has been documented decades after initial therapy with options for treating recurrent advanced stage disease. Prospective studies have been limited, and current studies aim to evaluate novel treatment options...
  3. pmc Gemcitabine alone versus gemcitabine plus radiotherapy in patients with locally advanced pancreatic cancer: an Eastern Cooperative Oncology Group trial
    Patrick J Loehrer
    Indiana University Melvin and Bren Simon Cancer Center, 980 West Walnut St, Suite C528, Indianapolis, IN 46202, USA
    J Clin Oncol 29:4105-12. 2011
    ..The purpose of this trial was to evaluate the role of radiation therapy with concurrent gemcitabine (GEM) compared with GEM alone in patients with localized unresectable pancreatic cancer...
  4. ncbi request reprint Octreotide alone or with prednisone in patients with advanced thymoma and thymic carcinoma: an Eastern Cooperative Oncology Group Phase II Trial
    Patrick J Loehrer
    Indiana University Medical Center, Indianapolis, IN 46202, USA
    J Clin Oncol 22:293-9. 2004
    ....
  5. ncbi request reprint Combined etoposide, ifosfamide, and cisplatin in the treatment of patients with advanced thymoma and thymic carcinoma: an intergroup trial
    P J Loehrer
    Department of Medicine, Indiana University School of Medicine and the Walther Cancer Institute, Indianapolis, Indiana, USA
    Cancer 91:2010-5. 2001
    ..The purpose of this trial was to evaluate the response rate, progression free survival, overall survival, and toxicity of combined etoposide, ifosfamide, and cisplatin (VIP) in patients with advanced thymoma and thymic carcinoma...
  6. ncbi request reprint Current approaches to the treatment of thymoma
    P J Loehrer
    Indiana University Medical Center, The Walther Cancer Institute, Indianapolis 46202 5289, USA
    Ann Med 31:73-9. 1999
    ..Indeed, even in advanced disease, systemic therapy may not only prolong the disease-free survival, but may also be curative in various malignancies. The therapy for patients with thymoma has been evolving over the past few years...
  7. ncbi request reprint Thymic malignancies
    P J Loehrer
    Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Cancer Treat Res 105:277-302. 2001
    ..Further information regarding the molecular nature of these neoplasms and immunologic aspects is needed in future investigation...
  8. ncbi request reprint Randomized comparison of cisplatin and etoposide and either bleomycin or ifosfamide in treatment of advanced disseminated germ cell tumors: an Eastern Cooperative Oncology Group, Southwest Oncology Group, and Cancer and Leukemia Group B Study
    C R Nichols
    Indiana University Medical Center, Indianapolis, USA
    J Clin Oncol 16:1287-93. 1998
    ..To compare standard therapy with bleomycin, etoposide, and cisplatin (BEP) to experimental therapy with etoposide, ifosfamide, and cisplatin (VIP) as primary treatment of men with advanced, disseminated germ cell tumors...
  9. ncbi request reprint Vinblastine plus ifosfamide plus cisplatin as initial salvage therapy in recurrent germ cell tumor
    P J Loehrer
    Indiana University Medical Center, Indianapolis, USA
    J Clin Oncol 16:2500-4. 1998
    ....
  10. ncbi request reprint Mediastinal yolk sac tumor. The Indiana University experience, 1976 to 1988
    S Saxman
    Department of Medicine, Indiana University School of Medicine, Indianapolis
    J Thorac Cardiovasc Surg 102:913-6. 1991
    ..New regimens need to be explored for relapse of the disease after initial chemotherapy...
  11. ncbi request reprint High-dose carboplatin with etoposide in patients with recurrent thymoma: the Indiana University experience
    N Hanna
    Indiana University, Indianapolis, IN 46202, USA
    Bone Marrow Transplant 28:435-8. 2001
    ..High-dose carboplatin and etoposide in relapsed thymoma is feasible with acceptable toxicity; however, these limited data do not appear superior to standard-dose salvage therapy...
  12. ncbi request reprint Thymoma and thymic carcinoma: therapeutic approaches
    Anupama Kurup
    Department of Hematology Oncology, Indiana University School of Medicine, Indianapolis, IN, USA
    Clin Lung Cancer 6:28-32. 2004
    ..Use of octreotide plus prednisone has produced responses in thymomas, but the dosing and schedule have not been clearly defined. Prospective studies have been limited, and, as such, enrollment in clinical trials is encouraged...
  13. ncbi request reprint Long-term follow-up of a phase III intergroup study of cisplatin alone or in combination with methotrexate, vinblastine, and doxorubicin in patients with metastatic urothelial carcinoma: a cooperative group study
    S B Saxman
    Indiana University School of Medicine, Indianapolis 46202, USA
    J Clin Oncol 15:2564-9. 1997
    ..We conducted a long-term analysis of patients included in the intergroup trial to examine factors associated with long-term survival...
  14. ncbi request reprint Antitumor effects of 5-fluorouracil on human colon cancer cell lines: antagonism by levamisole
    Eric A Wiebke
    Department of Surgery, Indiana University School of Medicine and Surgical Service, Roudebush VA Medical Center, Indianapolis, Indiana 46202, USA
    J Surg Res 111:63-9. 2003
    ..The mechanism of action of Lev remains unknown. Because we showed little in vitro immunological effect of Lev, we asked whether Lev, alone or in combination with 5-FU, had antitumor activity in vitro...
  15. ncbi request reprint Pancreaticoduodenectomy: a 20-year experience in 516 patients
    C Max Schmidt
    Department of Surgery, University Hospital, Indiana University School of Medicine, Indianapolis, USA
    Arch Surg 139:718-25; discussion 725-7. 2004
    ..Pancreaticoduodenectomy (PD) is a safe procedure for a variety of periampullary conditions...
  16. ncbi request reprint A Phase 1 dose-escalation trial of glufosfamide in combination with gemcitabine in solid tumors including pancreatic adenocarcinoma
    E Gabriela Chiorean
    Indiana University Cancer Center, 535 Barnhill Drive, Room 414, Indianapolis, IN 46202, USA
    Cancer Chemother Pharmacol 61:1019-26. 2008
    ..To evaluate safety and pharmacokinetics and to establish the maximum tolerated dose of glufosfamide when administered in combination with gemcitabine in advanced solid tumors...
  17. doi request reprint Rituximab for the treatment of thymoma-associated and de novo myasthenia gravis: 3 cases and review
    Robert P Nelson
    Division of Hematology Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Clin Neuromuscul Dis 10:170-7. 2009
    ..Rituximab, a monoclonal antibody specific for CD20, is used primarily to treat B-cell non-Hodgkin lymphoma. Although it has been used for treatment of a number of autoimmune diseases, there is limited experience in MG...
  18. doi request reprint A phase 2 trial of glufosfamide in combination with gemcitabine in chemotherapy-naive pancreatic adenocarcinoma
    Elena G Chiorean
    Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IN 46202, USA
    Am J Clin Oncol 33:111-6. 2010
    ..The purpose of this phase II study was to evaluate the safety and efficacy of this combination in chemotherapy-naive pancreatic adenocarcinoma...
  19. doi request reprint Prognostic indicators after surgery for thymoma
    Ikenna C Okereke
    Department of Surgery Cardiothoracic Division, Indiana University School of Medicine, Indianapolis, Indiana 46204, USA
    Ann Thorac Surg 89:1071-7; discussion 1077-9. 2010
    ..We undertook a 20-year retrospective institutional study to investigate prognostic indicators after surgery for thymoma...
  20. doi request reprint The role of chemotherapy in advanced thymoma
    Jordan Schmitt
    Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, Indiana, USA
    J Thorac Oncol 5:S357-60. 2010
    ..The remainder of will be candidates for systemic therapy. Numerous retrospective trials confirm objective responses to a variety of single-agent and combination chemotherapeutic regimens...
  21. ncbi request reprint Tyrosine kinase receptor expression in thymomas
    John D Henley
    Department of Pathology, Indiana University School of Medicine, Clarian Health Partners, 550 North University Blvd, Rm 3465, Indianapolis 46202, USA
    J Cancer Res Clin Oncol 130:222-4. 2004
    ..We previously demonstrated a high rate of epidermal growth factor receptor (EGFR) expression in advanced-stage thymic epithelial tumors. More recently, we have examined c-KIT (CD117) expression in a similar series of tumors...
  22. ncbi request reprint Maintenance daily oral etoposide versus no further therapy following induction chemotherapy with etoposide plus ifosfamide plus cisplatin in extensive small-cell lung cancer: a Hoosier Oncology Group randomized study
    N H Hanna
    Department of Medicine, Indiana University Medical Center, Indianapolis, USA
    Ann Oncol 13:95-102. 2002
    ....
  23. ncbi request reprint Thymoma: current medical and surgical management
    Kenneth A Kesler
    Thoracic Division, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Semin Neurol 24:63-73. 2004
    ..This chapter outlines the current medical and surgical treatment options for thymoma...
  24. ncbi request reprint Epidermal growth factor receptor expression in invasive thymoma
    J D Henley
    Department of Pathology, Indiana University School of Medicine, Clarian Health Partners, 550 North University Blvd, Rm 3465, Indianapolis, IN 46202, USA
    J Cancer Res Clin Oncol 128:167-70. 2002
    ..In clinical trials, anti-EGFR is showing promise in the treatment of solid tumors expressing EGFR. Thus, we assessed EGFR expression in a series of thymic epithelial tumors...
  25. ncbi request reprint Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor
    Leonard B Saltz
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Clin Oncol 22:1201-8. 2004
    ..To evaluate the antitumor activity and toxicity of single-agent cetuximab in patients with chemotherapy-refractory colorectal cancer whose tumors express the epidermal growth factor receptor...
  26. doi request reprint Retrospective analysis of the efficacy of gemcitabine for previously treated AIDS-associated Kaposi's sarcoma in western Kenya
    R Matthew Strother
    Indiana University School of Medicine, IU Simon Cancer Center, 535 Barnhill Drive, Indianapolis, IN 46202, USA
    Oncology 78:5-11. 2010
    ..Evaluation of outcomes in the use of single-agent gemcitabine for the treatment of AIDS-associated Kaposi's sarcoma (KS) in a western Kenyan cancer treatment program...
  27. doi request reprint Postoperative radiotherapy after surgical resection of thymoma: differing roles in localized and regional disease
    Jeffrey A Forquer
    Department of Radiation Oncology, Indiana University Melvin and Bren Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN, USA
    Int J Radiat Oncol Biol Phys 76:440-5. 2010
    ..To analyze the Surveillance, Epidemiology and End Results (SEER) registry data to determine the impact of postoperative radiotherapy (PORT) for thymoma and thymic carcinoma (T/TC)...
  28. ncbi request reprint Phase II study of paclitaxel plus gemcitabine in refractory germ cell tumors (E9897): a trial of the Eastern Cooperative Oncology Group
    Stuart Hinton
    Indiana University Medical Center and Walther Cancer Institute, Indianapolis, IN, USA
    J Clin Oncol 20:1859-63. 2002
    ..Paclitaxel and gemcitabine have shown activity as single agents in refractory germ cell tumors and can be combined with manageable toxicity...
  29. ncbi request reprint A phase I study of weekly gemcitabine and docetaxel in patients with advanced cancer: a Hoosier Oncology Group Study
    Kristen N Ganjoo
    Department of Medicine, Division of Hematology Oncology, Indiana University and The Walther Cancer Institute, Indianapolis, USA
    Oncology 62:299-304. 2002
    ..To determine the maximum tolerated dose (MTD) of weekly gemcitabine plus docetaxel, a dose escalation trial of both drugs was developed with each administered weekly for 3 weeks out of 4...
  30. ncbi request reprint Cisplatin, etoposide and either bleomycin or ifosfamide in the treatment of disseminated germ cell tumors: final analysis of an intergroup trial
    Stuart Hinton
    Department of Medicine, Indiana University Medical Center and The Walther Cancer Institute, Indianapolis, Indiana, USA
    Cancer 97:1869-75. 2003
    ....
  31. ncbi request reprint A phase I study of docetaxel, Cisplatin, 5-Fluorouracil and leucovorin
    Mary F Mulcahy
    Division of Hematology Oncology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Oncology 68:479-84. 2005
    ..This phase I study was undertaken to determine the maximally tolerated dose and dose-limiting toxicities of a combination of these drugs given in an ambulatory setting using a bolus schedule of 5-FU...
  32. pmc Phase II study of carboplatin and paclitaxel in advanced thymoma and thymic carcinoma
    Girum L Lemma
    Indiana University Melvin and Bren Simon Cancer Center, Indianapolis 46202, USA
    J Clin Oncol 29:2060-5. 2011
    ..The purpose of this study was to evaluate the impact of carboplatin and paclitaxel in patients with advanced previously untreated thymoma and thymic carcinoma...
  33. ncbi request reprint National Institutes of Health State-of-the-Science Conference Statement: ERCP for diagnosis and therapy, January 14-16, 2002
    Sidney Cohen
    Division of Gastroenterology and Hepatology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Gastrointest Endosc 56:803-9. 2002
  34. ncbi request reprint A phase II study of 13-cis retinoic acid plus interferon alpha-2a in advanced stage penile carcinoma: an Eastern Cooperative Oncology Group study (E3893)
    Roland T Skeel
    Medical College of Ohio, Toledo, Ohio, USA
    Cancer Invest 21:41-6. 2003
    ....
  35. ncbi request reprint A phase II trial of olanzapine, dexamethasone, and palonosetron for the prevention of chemotherapy-induced nausea and vomiting: a Hoosier oncology group study
    Rudolph M Navari
    Notre Dame Cancer Institute, University of Notre Dame, 224 Raclin Carmichael Hall, Notre Dame, IN 46556, USA
    Support Care Cancer 15:1285-91. 2007
    ....
  36. ncbi request reprint Carboplatin for stage I seminoma and the sword of Damocles
    Patrick J Loehrer
    J Clin Oncol 23:8566-9. 2005
  37. ncbi request reprint A phase II trial of olanzapine for the prevention of chemotherapy-induced nausea and vomiting: a Hoosier Oncology Group study
    Rudolph M Navari
    Walter Cancer Research Center, University of Notre Dame, 250 Nieuwland Science Hall, Notre Dame, IN 46556, USA
    Support Care Cancer 13:529-34. 2005
    ..Olanzapine is safe and highly effective in controlling acute and delayed chemotherapy-induced nausea and vomiting in patients receiving highly and moderately emetogenic chemotherapy...
  38. ncbi request reprint Fluoxetine versus placebo in advanced cancer outpatients: a double-blinded trial of the Hoosier Oncology Group
    Michael J Fisch
    Department of Palliative Care and Rehabilitation, University of Texas M D Anderson Cancer Center, Box 008, Room P12 2911, 1515 Holcombe Blvd, Houston, TX 77030 4009, USA
    J Clin Oncol 21:1937-43. 2003
    ..To determine whether fluoxetine improves overall quality of life (QOL) in advanced cancer patients with symptoms of depression revealed by a simple survey...
  39. ncbi request reprint Assessment of quality of life in outpatients with advanced cancer: the accuracy of clinician estimations and the relevance of spiritual well-being--a Hoosier Oncology Group Study
    Michael J Fisch
    The University of Texas M D Anderson Cancer Center, Unit 008, Rm P12 2911, 1515 Holcombe Blvd, Houston, TX 77030 4009, USA
    J Clin Oncol 21:2754-9. 2003
    ..To evaluate the association between quality-of-life (QOL) impairment as reported by patients and QOL impairment as judged by nurses or physicians, with and without consideration of spiritual well-being (SWB)...
  40. ncbi request reprint Stratification by risk factors predicts survival on the active treatment arm in a randomized phase II study of interferon-gamma plus/minus interferon-alpha in advanced renal cell carcinoma (E6890)
    Janice P Dutcher
    Our Lady of Mercy Cancer Center, NY Med College Bronx, New York 10466, USA
    Med Oncol 20:271-81. 2003
    ....

Research Grants3

  1. EASTERN COOPERATIVE ONCOLOGY GROUP
    Patrick Loehrer; Fiscal Year: 2004
    ..e., nurse, research nurse, and social worker) that clearly understands the importance of providing access to clinical research trials to this socially and economically disadvantaged population. ..
  2. EASTERN COOPERATIVE ONCOLOGY GROUP
    Patrick Loehrer; Fiscal Year: 2007
    ..e., nurse, research nurse, and social worker) that clearly understands the importance of providing access to clinical research trials to this socially and economically disadvantaged population. ..