Chien Chi Lin

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. pmc Cell-cell communication mimicry with poly(ethylene glycol) hydrogels for enhancing beta-cell function
    Chien Chi Lin
    Department of Biomedical Engineering, Indiana University Purdue University at Indianapolis, Indianapolis, IN 46202, USA
    Proc Natl Acad Sci U S A 108:6380-5. 2011
  2. pmc PEG hydrogels formed by thiol-ene photo-click chemistry and their effect on the formation and recovery of insulin-secreting cell spheroids
    Chien Chi Lin
    Department of Biomedical Engineering, Purdue School of Engineering and Technology, Indiana University Purdue University at Indianapolis, IN 46202, USA
    Biomaterials 32:9685-95. 2011
  3. pmc The influence of matrix degradation and functionality on cell survival and morphogenesis in PEG-based hydrogels
    Asad Raza
    Department of Biomedical Engineering, Purdue School of Engineering and Technology, Indiana University Purdue University at Indianapolis, Indianapolis, IN 46202, USA
    Macromol Biosci 13:1048-58. 2013
  4. pmc Visible light cured thiol-vinyl hydrogels with tunable degradation for 3D cell culture
    Yiting Hao
    Department of Biomedical Engineering, Purdue School of Engineering and Technology, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202, USA
    Acta Biomater 10:104-14. 2014
  5. doi request reprint Effect of 3D matrix compositions on the efficacy of EGFR inhibition in pancreatic ductal adenocarcinoma cells
    Chang Seok Ki
    Department of Biomedical Engineering, Purdue School of Engineering and Technology, Indiana University Purdue University at Indianapolis, Indianapolis, Indiana 46202, United States
    Biomacromolecules 14:3017-26. 2013
  6. pmc The influence of matrix properties on growth and morphogenesis of human pancreatic ductal epithelial cells in 3D
    Asad Raza
    Department of Biomedical Engineering, Purdue School of Engineering and Technology, Indiana University Purdue University at Indianapolis, Indianapolis, IN 46202, USA
    Biomaterials 34:5117-27. 2013
  7. pmc Interfacial thiol-ene photoclick reactions for forming multilayer hydrogels
    Han Shih
    Department of Biomedical Engineering, Purdue School of Engineering and Technology, Indiana University Purdue University Indianapolis IUPUI, 723 W Michigan St, SL220, Indianapolis, Indiana 46202, USA
    ACS Appl Mater Interfaces 5:1673-80. 2013
  8. doi request reprint Visible-light-mediated thiol-ene hydrogelation using eosin-Y as the only photoinitiator
    Han Shih
    Department of Biomedical Engineering, Indiana University Purdue University at Indianapolis, Indianapolis, IN 46202, USA
    Macromol Rapid Commun 34:269-73. 2013
  9. pmc Cross-linking and degradation of step-growth hydrogels formed by thiol-ene photoclick chemistry
    Han Shih
    Department of Biomedical Engineering, Purdue School of Engineering and Technology, Indiana University Purdue University at Indianapolis, Indianapolis, Indiana 46202, United States
    Biomacromolecules 13:2003-12. 2012
  10. pmc Thiol-ene hydrogels as desmoplasia-mimetic matrices for modeling pancreatic cancer cell growth, invasion, and drug resistance
    Chang Seok Ki
    Department of Biomedical Engineering, Purdue School of Engineering and Technology, Indianapolis University Purdue University Indianapolis, Indianapolis, IN 46202, USA Department of Biosystems and Biomaterials Science and Engineering, Seoul National University, Seoul 151 921, Republic of Korea
    Biomaterials 35:9668-77. 2014

Collaborators

  • Ping Zhang
  • Hui Bin Sun
  • Hiroki Yokota
  • Han Shih
  • Chang Seok Ki
  • Yiting Hao
  • Asad Raza
  • Tsai Yu Lin
  • Kazunori Hamamura
  • Murray Korc
  • Arika Kemp
  • Zachary Mu┼łoz
  • Liming Zhao
  • Joon W Shim
  • Qiaoqiao Wan
  • Todd R Dodge
  • Sungsoo Na
  • Andrew K Fraser
  • Andy Chen

Detail Information

Publications13

  1. pmc Cell-cell communication mimicry with poly(ethylene glycol) hydrogels for enhancing beta-cell function
    Chien Chi Lin
    Department of Biomedical Engineering, Indiana University Purdue University at Indianapolis, Indianapolis, IN 46202, USA
    Proc Natl Acad Sci U S A 108:6380-5. 2011
    ..This unique gel platform demonstrates new strategies for tailoring biomimetic environments to enhance the encapsulation of cells that require cell-cell contact to survive and function...
  2. pmc PEG hydrogels formed by thiol-ene photo-click chemistry and their effect on the formation and recovery of insulin-secreting cell spheroids
    Chien Chi Lin
    Department of Biomedical Engineering, Purdue School of Engineering and Technology, Indiana University Purdue University at Indianapolis, IN 46202, USA
    Biomaterials 32:9685-95. 2011
    ....
  3. pmc The influence of matrix degradation and functionality on cell survival and morphogenesis in PEG-based hydrogels
    Asad Raza
    Department of Biomedical Engineering, Purdue School of Engineering and Technology, Indiana University Purdue University at Indianapolis, Indianapolis, IN 46202, USA
    Macromol Biosci 13:1048-58. 2013
    ..The degree of 3D cell spreading in encapsulated hMSCs is enhanced when the matrices are immobilized with cell-adhesive motifs...
  4. pmc Visible light cured thiol-vinyl hydrogels with tunable degradation for 3D cell culture
    Yiting Hao
    Department of Biomedical Engineering, Purdue School of Engineering and Technology, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202, USA
    Acta Biomater 10:104-14. 2014
    ..Encapsulated hMSCs remained alive (>90%) throughout the duration of the study and the cells were differentiated down osteogenic lineage with varying degrees by controlling the rate and mode of gel degradation...
  5. doi request reprint Effect of 3D matrix compositions on the efficacy of EGFR inhibition in pancreatic ductal adenocarcinoma cells
    Chang Seok Ki
    Department of Biomedical Engineering, Purdue School of Engineering and Technology, Indiana University Purdue University at Indianapolis, Indianapolis, Indiana 46202, United States
    Biomacromolecules 14:3017-26. 2013
    ..These results shed light on the importance and non-negligible role of matrix properties on the efficacy of antitumor drugs...
  6. pmc The influence of matrix properties on growth and morphogenesis of human pancreatic ductal epithelial cells in 3D
    Asad Raza
    Department of Biomedical Engineering, Purdue School of Engineering and Technology, Indiana University Purdue University at Indianapolis, Indianapolis, IN 46202, USA
    Biomaterials 34:5117-27. 2013
    ..These studies have established PEG-peptide hydrogels formed by thiol-ene photo-click reaction as a suitable platform for studying and manipulating pancreatic epithelial cell growth and morphogenesis in 3D...
  7. pmc Interfacial thiol-ene photoclick reactions for forming multilayer hydrogels
    Han Shih
    Department of Biomedical Engineering, Purdue School of Engineering and Technology, Indiana University Purdue University Indianapolis IUPUI, 723 W Michigan St, SL220, Indianapolis, Indiana 46202, USA
    ACS Appl Mater Interfaces 5:1673-80. 2013
    ..This new gelation chemistry may have great utilities in controlled release of multiple sensitive growth factors and encapsulation of multiple cell types for tissue regeneration...
  8. doi request reprint Visible-light-mediated thiol-ene hydrogelation using eosin-Y as the only photoinitiator
    Han Shih
    Department of Biomedical Engineering, Indiana University Purdue University at Indianapolis, Indianapolis, IN 46202, USA
    Macromol Rapid Commun 34:269-73. 2013
    ....
  9. pmc Cross-linking and degradation of step-growth hydrogels formed by thiol-ene photoclick chemistry
    Han Shih
    Department of Biomedical Engineering, Purdue School of Engineering and Technology, Indiana University Purdue University at Indianapolis, Indianapolis, Indiana 46202, United States
    Biomacromolecules 13:2003-12. 2012
    ..In addition, we incorporated a chymotrypsin-sensitive peptide as part of the cross-linkers to tune the mode of gel degradation from bulk degradation to surface erosion...
  10. pmc Thiol-ene hydrogels as desmoplasia-mimetic matrices for modeling pancreatic cancer cell growth, invasion, and drug resistance
    Chang Seok Ki
    Department of Biomedical Engineering, Purdue School of Engineering and Technology, Indianapolis University Purdue University Indianapolis, Indianapolis, IN 46202, USA Department of Biosystems and Biomaterials Science and Engineering, Seoul National University, Seoul 151 921, Republic of Korea
    Biomaterials 35:9668-77. 2014
    ..This phenotype is likely a consequence of the enrichment of pancreatic cancer stem cells that expressed high levels of CD24, sonic hedgehog (SHH), and vascular endothelial growth factor (VEGF). ..
  11. pmc Knee loading reduces MMP13 activity in the mouse cartilage
    Kazunori Hamamura
    Department of Biomedical Engineering, Indiana University Purdue University Indianapolis, SL220C, 723 West Michigan Street, Indianapolis, IN 46202, USA
    BMC Musculoskelet Disord 14:312. 2013
    ..In this study, we examined the effects of knee loading on the activity of matrix metalloproteinase13 (MMP13) and evaluated the role of p38 MAPK and Rac1 GTPase in the regulation of MMP13...
  12. doi request reprint Degradable thiol-acrylate hydrogels as tunable matrices for three-dimensional hepatic culture
    Yiting Hao
    Department of Biomedical Engineering, Purdue School of Engineering and Technology, Indiana University Purdue University Indianapolis, Indianapolis, Indiana, 46202
    J Biomed Mater Res A 102:3813-27. 2014
    ..The addition of NVP at a higher concentration (0.3%) did not affect Huh7 cell viability but resulted in reduction of cell metabolic activity, which was accompanied by an elevated urea secretion from the encapsulated cells...
  13. doi request reprint Manipulating hepatocellular carcinoma cell fate in orthogonally cross-linked hydrogels
    Tsai Yu Lin
    Department of Biomedical Engineering, Purdue School of Engineering and Technology, Indiana University Purdue University at Indianapolis, 723 W Michigan St SL220K, Indianapolis, IN 46202, USA
    Biomaterials 35:6898-906. 2014
    ..The up-regulation of NTCP expression and restoration of hepatocyte-like polarity in our hydrogels also shed light on future study of hepatitis B virus infection in vitro...