Affiliation: Indiana University
Liangpunsakul S, Qi R, Crabb D, Witzmann F. Relationship between alcohol drinking and aspartate aminotransferase:alanine aminotransferase (AST:ALT) ratio, mean corpuscular volume (MCV), gamma-glutamyl transpeptidase (GGT), and apolipoprotein A1 and B in the U.S. population. J Stud Alcohol Drugs. 2010;71:249-52 pubmed
..More work is needed to find the novel marker(s) associated with risky alcohol drinking. ..
Liangpunsakul S, Rahmini Y, Ross R, Zhao Z, Xu Y, Crabb D. Imipramine blocks ethanol-induced ASMase activation, ceramide generation, and PP2A activation, and ameliorates hepatic steatosis in ethanol-fed mice. Am J Physiol Gastrointest Liver Physiol. 2012;302:G515-23 pubmed publisher
..ASMase inhibitors may be considered as a therapeutic target for alcohol-induced hepatic steatosis and activation of stress kinases. ..
Liangpunsakul S, Haber P, McCaughan G. Alcoholic Liver Disease in Asia, Europe, and North America. Gastroenterology. 2016;150:1786-97 pubmed publisher
..Treatment approaches, including availability of medications, models of care, and approach to transplantation, differ among regions. ..
Liangpunsakul S, Wou S, Zeng Y, Ross R, Jayaram H, Crabb D. Effect of ethanol on hydrogen peroxide-induced AMPK phosphorylation. Am J Physiol Gastrointest Liver Physiol. 2008;295:G1173-81 pubmed publisher
..The inhibitory effect of ethanol on AMPK phosphorylation is exerted through the inhibition of PKC-zeta and LKB1 phosphorylation and the activation of PP2A...
Liangpunsakul S, Ross R, Crabb D. Activation of carbohydrate response element-binding protein by ethanol. J Investig Med. 2013;61:270-7 pubmed publisher
..However, additional okadaic acid-insensitive effects appear to be important as well. ..
Kang X, Petyaykina K, Tao R, Xiong X, Dong X, Liangpunsakul S. The inhibitory effect of ethanol on Sestrin3 in the pathogenesis of ethanol-induced liver injury. Am J Physiol Gastrointest Liver Physiol. 2014;307:G58-65 pubmed publisher
..Our findings suggest that inhibitory effect of ethanol on Sesn3 may play an important role in the development of ethanol-induced fatty liver. ..
Liangpunsakul S, Toh E, Ross R, Heathers L, Chandler K, Oshodi A, et al
. Quantity of alcohol drinking positively correlates with serum levels of endotoxin and markers of monocyte activation. Sci Rep. 2017;7:4462 pubmed publisher
..We found an increase in the levels of LPS and markers of monocyte activations in ED. Further studies are needed to determine whether these can be used as the biomarkers for excessive alcohol use. ..
Liangpunsakul S, Sozio M, Shin E, Zhao Z, Xu Y, Ross R, et al
. Inhibitory effect of ethanol on AMPK phosphorylation is mediated in part through elevated ceramide levels. Am J Physiol Gastrointest Liver Physiol. 2010;298:G1004-12 pubmed publisher
..We concluded that the effect of ethanol on AMPK appears to be mediated in part through increased cellular levels of ceramide and activation of PP2A. ..
Liangpunsakul S, Puri P, Shah V, Kamath P, Sanyal A, Urban T, et al
. Effects of Age, Sex, Body Weight, and Quantity of Alcohol Consumption on Occurrence and Severity of Alcoholic Hepatitis. Clin Gastroenterol Hepatol. 2016;14:1831-1838.e3 pubmed publisher
..The risk for AH may be associated with the PNPLA3 rs738409 polymorphism. ..