T K Li

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. ncbi Alcohol reinforcement and voluntary ethanol consumption
    T K Li
    Indiana University School of Medicine, Indianapolis, Indiana
    Alcohol Clin Exp Res 25:117S-126S. 2001
  2. ncbi Genetic and environmental influences on alcohol metabolism in humans
    T K Li
    Department of Medicine, Indiana University School of Medicine, Indianapolis 46202, USA
    Alcohol Clin Exp Res 25:136-44. 2001
  3. ncbi Identification of quantitative trait loci influencing alcohol consumption in the high alcohol drinking and low alcohol drinking rat lines
    T Foroud
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis 46202, USA
    Behav Genet 30:131-40. 2000
  4. ncbi A quantitative trait locus for alcohol consumption in selectively bred rat lines
    L G Carr
    Department of Medicine, Indiana University School of Medicine, Indianapolis 46202, USA
    Alcohol Clin Exp Res 22:884-7. 1998
  5. ncbi Serotonin3 receptor antagonism of alcohol intake: effects of drinking conditions
    D L McKinzie
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis 46202 4887, USA
    Alcohol 15:291-8. 1998
  6. ncbi Genomic screen for QTLs underlying alcohol consumption in the P and NP rat lines
    P Bice
    Department of Medicine, Indiana University School of Medicine, Medical Research and Library Building, Room 407, 975 W Walnut Street, Indianapolis, Indiana 46202, USA
    Mamm Genome 9:949-55. 1998
  7. ncbi Regional CNS densities of monoamine receptors in alcohol-naive alcohol-preferring P and -nonpreferring NP rats
    W J McBride
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, USA
    Alcohol 14:141-8. 1997
  8. ncbi Ethanol-stimulated serotonin release in the ventral hippocampus: an absence of rapid tolerance for the alcohol-preferring P rat and insensitivity in the alcohol-nonpreferring NP rat
    R J Thielen
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Pharmacol Biochem Behav 71:111-7. 2002
  9. ncbi Low-dose stimulatory effects of ethanol during adolescence in rat lines selectively bred for high alcohol intake
    Z A Rodd
    Department of Psychiatry and Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202 4887, USA
    Alcohol Clin Exp Res 28:535-43. 2004
  10. ncbi Effects of neuropeptide Y on sucrose and ethanol intake and on anxiety-like behavior in high alcohol drinking (HAD) and low alcohol drinking (LAD) rats
    N E Badia-Elder
    Department of Psychology, Purdue School of Science, IUPUI, Indianapolis, Indiana, 46202 USA
    Alcohol Clin Exp Res 27:894-9. 2003

Detail Information

Publications107 found, 100 shown here

  1. ncbi Alcohol reinforcement and voluntary ethanol consumption
    T K Li
    Indiana University School of Medicine, Indianapolis, Indiana
    Alcohol Clin Exp Res 25:117S-126S. 2001
    ..Rodd-Henricks...
  2. ncbi Genetic and environmental influences on alcohol metabolism in humans
    T K Li
    Department of Medicine, Indiana University School of Medicine, Indianapolis 46202, USA
    Alcohol Clin Exp Res 25:136-44. 2001
    ..Ramchandani...
  3. ncbi Identification of quantitative trait loci influencing alcohol consumption in the high alcohol drinking and low alcohol drinking rat lines
    T Foroud
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis 46202, USA
    Behav Genet 30:131-40. 2000
    ..This study is the first genome-wide study for QTLs underlying alcohol consumption that has employed noninbred lines. Further localization of these QTLs will likely provide insight and candidate genes for the study of human alcoholism...
  4. ncbi A quantitative trait locus for alcohol consumption in selectively bred rat lines
    L G Carr
    Department of Medicine, Indiana University School of Medicine, Indianapolis 46202, USA
    Alcohol Clin Exp Res 22:884-7. 1998
    ..Localization of a gene influencing alcohol consumption may have important implications for the etiology of alcohol abuse and alcoholism in humans...
  5. ncbi Serotonin3 receptor antagonism of alcohol intake: effects of drinking conditions
    D L McKinzie
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis 46202 4887, USA
    Alcohol 15:291-8. 1998
    ..Furthermore, the results suggest that conditions, associated with limited access ethanol drinking, markedly reduce the actions of 5-HT3 antagonists on ethanol intake...
  6. ncbi Genomic screen for QTLs underlying alcohol consumption in the P and NP rat lines
    P Bice
    Department of Medicine, Indiana University School of Medicine, Medical Research and Library Building, Room 407, 975 W Walnut Street, Indianapolis, Indiana 46202, USA
    Mamm Genome 9:949-55. 1998
    ..It therefore appears likely that, in addition to the QTL on Chr 4, multiple loci of small to moderate effect, such as those on Chrs 3 and 8, underlie the difference in alcohol consumption in the P/NP lines...
  7. ncbi Regional CNS densities of monoamine receptors in alcohol-naive alcohol-preferring P and -nonpreferring NP rats
    W J McBride
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, USA
    Alcohol 14:141-8. 1997
    ....
  8. ncbi Ethanol-stimulated serotonin release in the ventral hippocampus: an absence of rapid tolerance for the alcohol-preferring P rat and insensitivity in the alcohol-nonpreferring NP rat
    R J Thielen
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Pharmacol Biochem Behav 71:111-7. 2002
    ..In addition, the data suggest that the 5-HT system in the vHIP of NP rats may be relatively insensitive to the stimulating effect of acute ethanol of 5-HT release...
  9. ncbi Low-dose stimulatory effects of ethanol during adolescence in rat lines selectively bred for high alcohol intake
    Z A Rodd
    Department of Psychiatry and Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202 4887, USA
    Alcohol Clin Exp Res 28:535-43. 2004
    ....
  10. ncbi Effects of neuropeptide Y on sucrose and ethanol intake and on anxiety-like behavior in high alcohol drinking (HAD) and low alcohol drinking (LAD) rats
    N E Badia-Elder
    Department of Psychology, Purdue School of Science, IUPUI, Indianapolis, Indiana, 46202 USA
    Alcohol Clin Exp Res 27:894-9. 2003
    ....
  11. ncbi Research advances in ethanol metabolism
    V A Ramchandani
    Department of Medicine, Indiana University School of Medicine, 975, W Walnut Street, IB 424, Indianapolis, IN 46202 5121, USA
    Pathol Biol (Paris) 49:676-82. 2001
    ....
  12. ncbi Local cerebral glucose utilization rates in alcohol-naïve high-alcohol-drinking (HAD) and low-alcohol-drinking (LAD) rats
    J E Learn
    Program in Medical Neurobiology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Alcohol Clin Exp Res 25:517-23. 2001
    ..01). CONCLUSIONS: The findings suggested that, within the HAD and LAD replicate rat lines, the selection for alcohol preference did not lead to differences in functional brain activity, as measured with the 2-DG method...
  13. ncbi Effects of 5-HT(3) receptor antagonists on daily alcohol intake under acquisition, maintenance, and relapse conditions in alcohol-preferring (P) rats
    Z A Rodd-Henricks
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis 46202 4887, USA
    Alcohol 21:73-85. 2000
    ....
  14. ncbi Alcohol place preference conditioning in high- and low-alcohol preferring selected lines of mice
    N J Grahame
    Institute for Psychiatric Research, Indiana University School of Medicine, Indianapolis 46202, USA
    Pharmacol Biochem Behav 68:805-14. 2001
    ..Low drinking in LAP mice may emerge from innate taste avoidance of alcohol as a result of selective breeding for low preference, which prevents them from encountering alcohol's rewarding, pharmacological effects...
  15. ncbi Innate differences of neuropeptide Y (NPY) in hypothalamic nuclei and central nucleus of the amygdala between selectively bred rats with high and low alcohol preference
    B H Hwang
    Department of Anatomy, School of Medicine, Indiana University, Indianapolis, 46202, USA
    Alcohol Clin Exp Res 23:1023-30. 1999
    ....
  16. ncbi Ethanol drinking and deprivation alter dopaminergic and serotonergic function in the nucleus accumbens of alcohol-preferring rats
    R J Thielen
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University Medical Center, 791 Union Drive, Indianapolis, IN 46202 4887, USA
    J Pharmacol Exp Ther 309:216-25. 2004
    ....
  17. ncbi Effect of neuropeptide Y (NPY) on oral ethanol intake in Wistar, alcohol-preferring (P), and -nonpreferring (NP) rats
    N E Badia-Elder
    Department of Psychology, Purdue School of Science, IUPUI, Indiana University School of Medicine, Indianapolis 46202, USA
    Alcohol Clin Exp Res 25:386-90. 2001
    ..Thus, ethanol drinking may be inversely associated with NPY activity. To determine whether exogenously administered NPY would alter ethanol intake, two experiments were conducted...
  18. ncbi Ethanol locomotor sensitization, but not tolerance correlates with selection for alcohol preference in high- and low-alcohol preferring mice
    N J Grahame
    Department of Medicine, Institute for Psychiatric Research, Indianapolis, IN 46202, USA
    Psychopharmacology (Berl) 151:252-60. 2000
    ..The present studies used selected lines of mice to assess genetic correlations among ethanol drinking, ethanol locomotor sensitization, and tolerance to the depressant effects of ethanol...
  19. ncbi Limited access alcohol drinking in high- and low-alcohol preferring selected lines of mice
    N J Grahame
    Department of Medicine, Indiana University School of Medicine, Indianapolis, USA
    Alcohol Clin Exp Res 23:1015-22. 1999
    ..To this end, high- and low-alcohol preferring (HAP and LAP, respectively) mice, selected for differences in 24-hr access alcohol drinking over a 4-week period, were subjected to a limited access alcohol drinking protocol...
  20. ncbi Effects of concurrent access to multiple ethanol concentrations and repeated deprivations on alcohol intake of alcohol-preferring rats
    Z A Rodd-Henricks
    Department of Psychiatry, Indiana University School of Medicine and Veterans Assistance Medical Center, Indianapolis, Indiana 46202 4887, USA
    Alcohol Clin Exp Res 25:1140-50. 2001
    ..This study examined the effects of initial deprivation length, concurrent exposure to multiple ethanol concentrations, and number of deprivation exposures on the magnitude and duration of the ADE in alcohol-preferring (P) rats...
  21. ncbi Responsivity and development of tolerance to the motor impairing effects of moderate doses of ethanol in alcohol-preferring (P) and -nonpreferring (NP) rat lines
    R L Bell
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis 46202-4887, USA
    Alcohol Clin Exp Res 25:644-50. 2001
    ..The present results confirm past research supporting an association between ethanol preference and low ethanol responsivity but at doses that are more reflective of those self-administered by P rats...
  22. ncbi Self-reported subjective perception of intoxication reflects family history of alcoholism when breath alcohol levels are constant
    Sandra L Morzorati
    Departments of Psychiatry, Indiana University School of Medicine, 791 Union Drive, Indianapolis, IN 46202 4887, USA
    Alcohol Clin Exp Res 26:1299-306. 2002
    ..This study tested the hypothesis that family history-positive (FHP) subjects are more sensitive and more adaptive to alcohol compared with family history-negative (FHN) subjects...
  23. ncbi Corticotropin-releasing factor gene expression is down-regulated in the central nucleus of the amygdala of alcohol-preferring rats which exhibit high anxiety: a comparison between rat lines selectively bred for high and low alcohol preference
    Bang H Hwang
    Department of Anatomy and Cell Biology MS 5035, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA
    Brain Res 1026:143-50. 2004
    ..Collectively, the present study suggests that reduced CRF gene expression in the CeA of P rats is associated with their alcohol preference and anxiety...
  24. ncbi Regional central nervous system densities of delta-opioid receptors in alcohol-preferring P, alcohol-nonpreferring NP, and unselected Wistar rats
    W N Strother
    Department of Psychiatry, Institute of Psychiatric Research, 791 Union Drive, Indianapolis, IN 46202 4887, USA
    Alcohol 25:31-8. 2001
    ....
  25. ncbi Induction of steady-state blood alcohol levels: application to the study of within-session alcohol tolerance in rats
    J C Froehlich
    Department of Medicine, Indiana University School of Medicine, Indianapolis 46202 5124, USA
    Alcohol Clin Exp Res 25:370-6. 2001
    ..This study characterizes a method for maintaining steady-state blood alcohol levels over several hours in the rat, referred to as the "alcohol clamp."..
  26. ncbi Effect of cellular retinol-binding protein on retinol oxidation by human class IV retinol/alcohol dehydrogenase and inhibition by ethanol
    N Y Kedishvili
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, 46202 5122, USA
    Biochem Biophys Res Commun 249:191-6. 1998
    ..Physiological levels of ethanol will substantially inhibit the oxidation of free retinol by human ADHs: class I, alpha alpha and beta 2 beta 2; class II, pi pi; and class IV, sigma sigma...
  27. ncbi Effects of the benzodiazepine inverse agonist RO19-4603 alone and in combination with the benzodiazepine receptor antagonists flumazenil, ZK 93426 and CGS 8216, on ethanol intake in alcohol-preferring (P) rats
    H L June
    Department of Psychology, Purdue School of Science, Indiana University Purdue University, Indianapolis 46202, USA
    Brain Res 734:19-34. 1996
    ..That certain BDZ inverse agonists can attenuate motivated behavior for EtOH reinforcement over a prolonged time course may provide a possible therapeutic approach to reducing EtOH consumption associated with alcoholism...
  28. ncbi Selective breeding for high and low alcohol preference in mice
    N J Grahame
    Department of Medicine, Indiana University School of Medicine, Indianapolis, USA
    Behav Genet 29:47-57. 1999
    ..Because the mouse genome is relatively well characterized, these selected lines should prove a useful tool for assessment of the genetic basis of, and phenotypes that correlate with, alcohol drinking...
  29. ncbi Analysis of heritability of hormonal responses to alcohol in twins: beta-endorphin as a potential biomarker of genetic risk for alcoholism
    J C Froehlich
    Department of Medicine, Indiana University School of Medicine, Indianapolis 46202 5124, USA
    Alcohol Clin Exp Res 24:265-77. 2000
    ..The present study was designed to determine whether hormonal responses to alcohol are heritable...
  30. ncbi Response of saccadic eye movements to alcohol in African American and non-Hispanic white college students
    T Blekher
    Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN 46202 5175, USA
    Alcohol Clin Exp Res 26:232-8. 2002
    ..The primary goal of this study was to evaluate how race and sex interact with the effects of a moderate dose of alcohol on different ocular control subsystems in African American (AA) and non-Hispanic white American (WA) college students...
  31. ncbi Mapping of QTL influencing saccharin consumption in the selectively bred alcohol-preferring and -nonpreferring rat lines
    T Foroud
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis 46202, USA
    Behav Genet 32:57-67. 2002
    ..The QTL on chromosome 18 has a maximum lod score of 2.7 with saccharin consumption. Taken together, these data provide the first results of a genome screen for QTLs contributing to saccharin phenotypes in the rat...
  32. ncbi Quantitative autoradiography of mu-opioid receptors in the CNS of high-alcohol-drinking (HAD) and low-alcohol-drinking (LAD) rats
    J E Learn
    Program in Medical Neurobiology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Alcohol Clin Exp Res 25:524-30. 2001
    ..Instead, the present results, in combination with previously published findings, suggest that the mu-opioid system may play a complex role in regulating high-alcohol-drinking behavior...
  33. ncbi Alcoholism susceptibility loci: confirmation studies in a replicate sample and further mapping
    T Foroud
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis 46202, USA
    Alcohol Clin Exp Res 24:933-45. 2000
    ..A previous study reported linkage to chromosomes 1, 2, and 7 in a large data set that consisted of 105 families, each with at least three alcoholic members...
  34. ncbi Effect of food and food composition on alcohol elimination rates in healthy men and women
    V A Ramchandani
    Department of Medicine, Indiana University School of Medicine, Indianapolis 46202-5121, USA
    J Clin Pharmacol 41:1345-50. 2001
    ..Probable mechanisms for the increased alcohol elimination includefood-induced increases in hepatic blood flow and in the activity of alcohol-metabolizing enzymes...
  35. ncbi Effects of acamprosate on sensitization to the locomotor-stimulant effects of alcohol in mice selectively bred for high and low alcohol preference
    J A Chester
    Department of Medicine, Indiana University School of Medicine, IB 420, 975 W Walnut Street, Indianapolis, IN 46202, USA
    Behav Pharmacol 12:535-43. 2001
    ..These data suggest complex effects of acamprosate on alcohol-stimulated locomotor activity that depend on genotype...
  36. ncbi A twin study of genetic influences on the acute adaptation of the EEG to alcohol
    S O'CONNOR
    Department of Psychiatry, Alcohol Research Center of the Indiana University School of Medicine and the Roudebush Veterans Affairs Medical Center, Indianapolis 46202, USA
    Alcohol Clin Exp Res 23:494-501. 1999
    ..Thus, heritable drowsiness may have contributed to detection of genetic influences on acute adaptation, but represent a potential confound only in the theta band...
  37. ncbi Gender differences in alcohol metabolism: relationship to liver volume and effect of adjusting for body mass
    P Y Kwo
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Gastroenterology 115:1552-7. 1998
    ..Some studies have demonstrated faster rates of alcohol elimination in women. This study examined whether gender differences in alcohol metabolism are related to differences in liver volume and/or differences in lean body mass...
  38. ncbi The expression of an alcohol deprivation effect in the high-alcohol-drinking replicate rat lines is dependent on repeated deprivations
    Z A Rodd-Henricks
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine and VA Medical Center, Indiana University Purdue University at Indianapolis, 46202 4887, USA
    Alcohol Clin Exp Res 24:747-53. 2000
    ..In the current study, we examined the effects of initial deprivation length and number of deprivation exposures on the ADE in the replicate lines of the high-alcohol-drinking (HAD) rats...
  39. ncbi Genetics of alcoholism: a review of recent studies in human and animal models
    T Foroud
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis 46202, USA
    Am J Addict 8:261-78. 1999
    ..Through the development of congenic lines and transgenic and knock-out animals, candidate genes can be identified and evaluated for their role in alcohol preference...
  40. ncbi Long-term effects of alcohol drinking on cerebral glucose utilization in alcohol-preferring rats
    D G Smith
    Program in Psychobiology of Addictions, Department of Psychology, Purdue School of Science, Indiana University-Purdue University, Indianapolis, IN 46202-4887, USA
    Pharmacol Biochem Behav 69:543-53. 2001
    ..Such neuronal imbalances may underlie relapse of alcohol drinking following prolonged abstinence...
  41. ncbi Genotypes for aldehyde dehydrogenase deficiency and alcohol sensitivity. The inactive ALDH2(2) allele is dominant
    D W Crabb
    Department of Medicine, Indiana University School of Medicine, Indianapolis 46223
    J Clin Invest 83:314-6. 1989
    ..Correlating genotype with phenotype leads to the conclusion that the allele (ALDH2(2)) encoding the abnormal subunit is dominant...
  42. ncbi The quantitative determination of R- and S-salsolinol in the striatum and adrenal gland of rats selectively bred for disparate alcohol drinking
    H Haber
    Indiana University School of Medicine, Institute of Psychiatric Research, Indianapolis, Indiana, USA hanka
    Addict Biol 4:181-9. 1999
    ..These results suggest a role for genetic factors in the formation of endogenous salsolinol and its potential regulation by short-term alcohol intake...
  43. ncbi Norepinephrine uptake sites in the locus coeruleus of rat lines selectively bred for high and low alcohol preference: a quantitative autoradiographic binding study using [3H]-tomoxetine
    B H Hwang
    Department of Anatomy, School of Medicine, Indiana University, Indianapolis 46202, USA
    Alcohol Clin Exp Res 24:588-94. 2000
    ..However, it is unknown whether NE uptake sites in the LC are associated with alcohol preference in AP and HAD rats when compared with their respective control rats, NP and LAD rats. This study was designed to examine this question...
  44. ncbi cDNA sequence and catalytic properties of a chick embryo alcohol dehydrogenase that oxidizes retinol and 3beta,5alpha-hydroxysteroids
    N Y Kedishvili
    Department of Biochemistry and Molecular Biology, Purdue University, Indianapolis, Indiana 46202 5122, USA
    J Biol Chem 272:7494-500. 1997
    ..Antiserum against ADH-F recognized corresponding protein in the chicken liver homogenate. We suggest that ADH-F represents a new class of alcohol dehydrogenase, class VII, based on its primary structure and catalytic properties...
  45. ncbi Innate differences in neuropeptide Y (NPY) mRNA expression in discrete brain regions between alcohol-preferring (P) and -nonpreferring (NP) rats: a significantly low level of NPY mRNA in dentate gyrus of the hippocampus and absence of NPY mRNA in the medi
    Bang H Hwang
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA
    Neuropeptides 38:359-68. 2004
    ..Our study suggests that lower NPY gene expression in the DG and MHb of P rats may be factors contributing to some of the phenotypic differences observed between the P and NP lines of rats...
  46. ncbi Confirmation of alcohol preference quantitative trait loci in the replicate high alcohol drinking and low alcohol drinking rat lines
    Tatiana Foroud
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, 975 West Walnut Street IB 155, Indianapolis, IN 46202, USA
    Psychiatr Genet 13:155-61. 2003
    ....
  47. ncbi Effects of concurrent access to a single concentration or multiple concentrations of ethanol on ethanol intake by periadolescent high-alcohol-drinking rats
    Richard L Bell
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Alcohol 33:107-15. 2004
    ....
  48. ncbi Using the cue-availability paradigm to assess cue reactivity
    Dena Davidson
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA
    Alcohol Clin Exp Res 27:1251-6. 2003
    ..The cue-availability paradigm is a modification of the conventional cue-reactivity paradigm and is intended to increase the sensitivity of measuring cue-reactivity to alcohol in humans...
  49. ncbi Regional heterogeneity for the intracranial self-administration of ethanol and acetaldehyde within the ventral tegmental area of alcohol-preferring (P) rats: involvement of dopamine and serotonin
    Zachary A Rodd
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University Purdue University at Indianapolis, Indianapolis, IN, USA
    Neuropsychopharmacology 30:330-8. 2005
    ..Furthermore, activation of 5-HT3 receptors within the posterior VTA is involved in the self-infusion of EtOH, but not ACD...
  50. ncbi Comparison of intracranial self-administration of ethanol within the posterior ventral tegmental area between alcohol-preferring and Wistar rats
    Zachary A Rodd
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46202 4887, USA
    Alcohol Clin Exp Res 28:1212-9. 2004
    ....
  51. ncbi AA and ANA rats exhibit the R100Q mutation in the GABAA receptor alpha 6 subunit
    Lucinda G Carr
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Alcohol 31:93-7. 2003
    ..The absence of the R100Q mutation in the other rat lines that were selectively bred for alcohol consumption and alcohol preference may be due to genetic diversity among the Wistar stocks used to develop the various lines...
  52. ncbi Alcohol-related olfactory cues activate the nucleus accumbens and ventral tegmental area in high-risk drinkers: preliminary findings
    David A Kareken
    Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Alcohol Clin Exp Res 28:550-7. 2004
    ..The mesocorticolimbic dopamine system is implicated in motivation and reward and may be involved in the development of alcoholism...
  53. ncbi Effects of long-term episodic access to ethanol on the expression of an alcohol deprivation effect in low alcohol-consuming rats
    Richard L Bell
    Indiana University School of Medicine, Department of Psychiatry, Institute of Psychiatric Research, 791 Union Drive, Indianapolis, IN 46202 4887, USA
    Alcohol Clin Exp Res 28:1867-74. 2004
    ..In addition, both P and HAD rats display an alcohol deprivation effect (ADE). This study was undertaken to test whether the NP, LAD-1, and LAD-2 lines of rats could display an ADE as well...
  54. ncbi Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations
    Howard J Edenberg
    Indiana University School of Medicine, Indianapolis 46202, USA
    Am J Hum Genet 74:705-14. 2004
    ....
  55. ncbi Analyses of quantitative trait loci contributing to alcohol preference in HAD1/LAD1 and HAD2/LAD2 rats
    Lucinda G Carr
    Department of Medicine, Indiana University School of Medicine, Indianapolis 46202, USA
    Alcohol Clin Exp Res 27:1710-7. 2003
    ..Previously, a 20-cM genome screen identified quantitative trait loci (QTLs) on chromosomes 5, 10, 12, and 16 by using F2 progeny from HAD1 and LAD1 animals...
  56. ncbi A genomic scan for habitual smoking in families of alcoholics: common and specific genetic factors in substance dependence
    Laura Jean Bierut
    School of Medicine, Washington University School of Medicine, 4940 Children s Place, St Louis, MO 63110, USA
    Am J Med Genet A 124:19-27. 2004
    ..Finally, there is also evidence of an area on chromosome 2 that may reflect a common genetic vulnerability locus to both habitual smoking and alcohol dependence...
  57. ncbi Dopamine and serotonin content in select brain regions of weanling and adult alcohol drinking rat lines
    Wendy N Strother
    Department of Psychiatry and Institute of Psychiatric Research, 791 Union Drive, Indianapolis, IN, 46202 4887, USA
    Pharmacol Biochem Behav 80:229-37. 2005
    ..These results confirm previous findings of an association between innate low DA content in select limbic regions and high alcohol drinking behavior...
  58. ncbi Determinants of alcohol use and abuse: Impact of quantity and frequency patterns on liver disease
    Samir Zakhari
    National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892 9304, USA
    Hepatology 46:2032-9. 2007
    ..A better understanding of these relationships will guide hepatologists in managing alcoholic liver disease...
  59. ncbi Is there a future for quantifying drinking in the diagnosis, treatment, and prevention of alcohol use disorders?
    Ting Kai Li
    National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, U S Depart ment of Health and Human Services, Bethesda, MD 20892 9304, USA
    Alcohol Alcohol 42:57-63. 2007
  60. ncbi Longitudinal brain magnetic resonance imaging study of the alcohol-preferring rat. Part I: adult brain growth
    Edith V Sullivan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, USA
    Alcohol Clin Exp Res 30:1234-47. 2006
    ....
  61. ncbi Changes in liver protein abundance in inbred alcohol-preferring rats due to chronic alcohol exposure, as measured through a proteomics approach
    Iveta Klouckova
    Department of Chemistry, Indiana University, 800 E. Kirkwood Avenue, Bloomington, IN 47405, USA
    Proteomics 6:3060-74. 2006
    ..In addition, enzymes involved in protein synthesis and antioxidant activity show significant changes in abundance in response to alcohol exposure...
  62. ncbi Identification of QTLs influencing alcohol preference in the High Alcohol Preferring (HAP) and Low Alcohol Preferring (LAP) mouse lines
    Paula J Bice
    Department of Medicine, Indiana University School of Medicine, Indianapolis, 46202, USA
    Behav Genet 36:248-60. 2006
    ..19; p<0.0008) than male mice (LOD=1.19). This study provides additional evidence and confirmation that specific regions on chromosomes 9 and perhaps 2 are important for alcohol preference...
  63. ncbi Protective effects of the alcohol dehydrogenase-ADH1B allele in children exposed to alcohol during pregnancy
    Sandra W Jacobson
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI 48207, USA
    J Pediatr 148:30-7. 2006
    ..To examine alcohol use for mothers with and without an ADH1B*3 allele and the moderating effects of the maternal and child ADH1B*3 allele on a broad range of infant and 7.5-year outcomes...
  64. ncbi Prolonged increase in the sensitivity of the posterior ventral tegmental area to the reinforcing effects of ethanol following repeated exposure to cycles of ethanol access and deprivation
    Zachary A Rodd
    Institute of Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, 46202, USA
    J Pharmacol Exp Ther 315:648-57. 2005
    ..Chronic alcohol drinking by P rats increased the reinforcing effects of ethanol within the posterior VTA, and repeated alcohol deprivations produced a further increase in these reinforcing effects of ethanol...
  65. ncbi Effects of acute administration of ethanol on cerebral glucose utilization in adult alcohol-preferring and alcohol-nonpreferring rats
    Wendy N Strother
    Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, IN 46202 4887, USA
    Alcohol 35:119-28. 2005
    ..These findings support the suggestion that certain central nervous system regions of P rats may be more sensitive than those of NP rats to the effects of low to intermediate doses of ethanol...
  66. ncbi Quantifying the risks associated with exceeding recommended drinking limits
    Deborah A Dawson
    Laboratory of Epidemiology and Biometry Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892 9304, USA
    Alcohol Clin Exp Res 29:902-8. 2005
    ....
  67. ncbi Sedative and motor-impairing effects of neuropeptide Y and ethanol in selectively bred P and NP rats
    Nicholas W Gilpin
    Department of Psychology, Purdue School of Science, IUPUI, LD 124, 402 N. Blackford Street, Indianapolis, IN 46202, USA
    Pharmacol Biochem Behav 78:65-73. 2004
    ..Taken together, these results provide partial support for past observations of additivity between NPY and drug-induced sedation, and suggest a role for NPY in the neurobehavioral effects of acute ethanol exposure...
  68. ncbi Genetic polymorphisms: impact on the risk of fetal alcohol spectrum disorders
    Kenneth R Warren
    Office of Scientific Affairs, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health DHHS, 5635 Fishers Lane MSC 9304, Bethesda, MD 20892 9304, USA
    Birth Defects Res A Clin Mol Teratol 73:195-203. 2005
    ..Understanding of the array of genetic factors in FASD will be enhanced by future genetic investigations, including case-control, family association, and linkage studies...
  69. ncbi Chronic ethanol drinking by alcohol-preferring rats increases the sensitivity of the posterior ventral tegmental area to the reinforcing effects of ethanol
    Zachary A Rodd
    Institute of Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, Indiana University, 791 Union Drive, Indianapolis, IN 46202, USA
    Alcohol Clin Exp Res 29:358-66. 2005
    ..The objective of this study was to test the hypothesis that chronic ethanol drinking increases the sensitivity of the posterior VTA to the reinforcing effects of ethanol...
  70. ncbi The role of acetaldehyde in the central effects of ethanol
    Etienne Quertemont
    Neuroscience Comportementale et Psychopharmacologie, University of Liege, Liege, Belgium
    Alcohol Clin Exp Res 29:221-34. 2005
    ..McBride, Zachary A. Rodd, Avram Goldstein, Alejandro Zaffaroni and Ting-Kai Li; and (5) Acetaldehyde increases dopaminergic transmission in the limbic system, by Milena Pisano and Marco Diana...
  71. ncbi The reinforcing properties of salsolinol in the ventral tegmental area: evidence for regional heterogeneity and the involvement of serotonin and dopamine
    Zachary A Rodd
    Institute of Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46202 4887, USA
    Alcohol Clin Exp Res 32:230-9. 2008
    ..The current study examined SAL self-infusions into the VTA, and determined the involvement of dopamine neurons and 5-HT3 receptors in this process...
  72. ncbi Moderate alcohol exposure compromises neural tube midline development in prenatal brain
    Feng C Zhou
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA
    Brain Res Dev Brain Res 144:43-55. 2003
    ....
  73. ncbi Regional CNS densities of serotonin 1A and dopamine D2 receptors in periadolescent alcohol-preferring P and alcohol-nonpreferring NP rat pups
    Wendy N Strother
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University Medical Center, Indiana University School of Medicine, 791 Union Drive, Indianapolis, IN 46202 4887, USA
    Pharmacol Biochem Behav 74:335-42. 2003
    ....
  74. ncbi Cocaine is self-administered into the shell but not the core of the nucleus accumbens of Wistar rats
    Zachary A Rodd-Henricks
    Institute of Psychiatric Research and Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46202 4887, USA
    J Pharmacol Exp Ther 303:1216-26. 2002
    ..These findings suggest that the AcbSh is a neuroanatomical substrate for the reinforcing effects of cocaine and that activation of D2-like receptors is involved...
  75. ncbi Effects of ethanol exposure on subsequent acquisition and extinction of ethanol self-administration and expression of alcohol-seeking behavior in adult alcohol-preferring (P) rats: II. Adult exposure
    Zachary A Rodd-Henricks
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis 46202 4887, USA
    Alcohol Clin Exp Res 26:1642-52. 2002
    ..The objective of the present study was to determine if EtOH consumption during adulthood produced similar effects on subsequent operant behaviors...
  76. ncbi Effects of ethanol exposure on subsequent acquisition and extinction of ethanol self-administration and expression of alcohol-seeking behavior in adult alcohol-preferring (P) rats: I. Periadolescent exposure
    Zachary A Rodd-Henricks
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis 46202 4887, USA
    Alcohol Clin Exp Res 26:1632-41. 2002
    ....
  77. ncbi Phenotypic and genotypic characterization of the Indiana University rat lines selectively bred for high and low alcohol preference
    James M Murphy
    Department of Psychology, Purdue School of Science, Indiana University Purdue University Indianapolis, 46202 1375, USA
    Behav Genet 32:363-88. 2002
    ..The elucidation of the genotypes and phenotypes that result in excessive alcohol intake may lead to a better understanding of alcohol abuse and alcoholism and could guide strategies for potential treatment and prevention...
  78. ncbi Saccadic eye movements are associated with a family history of alcoholism at baseline and after exposure to alcohol
    Tanya Blekher
    Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana 46202 5175, USA
    Alcohol Clin Exp Res 26:1568-73. 2002
    ..To evaluate the influence of family history of alcoholism (FHA) on the response of saccadic eye movements to alcohol...
  79. ncbi Alcohol dependence symptoms and alcohol dehydrogenase 2 polymorphism: Israeli Ashkenazis, Sephardics, and recent Russian immigrants
    Deborah Hasin
    Division of Epidemiology, Mailman School of Public Health and the Department of Psychiatry Colle of Physicians and Surgeons, Columbia University, and the New York State Psychiatric Institute, New York, New York 10032, USA
    Alcohol Clin Exp Res 26:1315-21. 2002
    ..We studied the relationship of ADH2*2 to DSM-IV dependence severity in a random community sample of Israeli Ashkenazis, recent Russian immigrants (also Ashkenazis), and Sephardics...
  80. ncbi Influence of ADH1B polymorphism on alcohol use and its subjective effects in a Jewish population
    Lucinda G Carr
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Am J Med Genet 112:138-43. 2002
    ..The ADH1B polymorphism is associated with unpleasant reactions after alcohol consumption, and frequency of alcohol consumption in these Jewish samples...
  81. ncbi Heart rate and motor-activating effects of orally self-administered ethanol in alcohol-preferring (P) rats
    Richard L Bell
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, 791 Union Drive, Indianapolis, IN 46202 4887, USA
    Alcohol Clin Exp Res 26:1162-70. 2002
    ..This study examined changes in heart rate (HR) and motor activity before and during limited-access to ethanol, saccharin, or water in adult male alcohol-preferring (P) rats...
  82. ncbi Alcohol and ADH2 in Israel: Ashkenazis, Sephardics, and recent Russian immigrants
    Deborah Hasin
    Division of Epidemiology, Mailman School of Public Health, Columbia University, New York 10032, USA
    Am J Psychiatry 159:1432-4. 2002
    ....
  83. ncbi Local cerebral glucose utilization after relapse in ethanol drinking in alcohol-preferring (P) rats
    Daniel G Smith
    Program in Psychobiology of Addictions, Department of Psychology, Purdue School of Science, Indiana University-Purdue University at Indianapolis, Indianapolis, IN 46202, USA
    Alcohol 27:115-26. 2002
    ....
  84. ncbi Microdialysis of dopamine in the nucleus accumbens of alcohol-preferring (P) rats during anticipation and operant self-administration of ethanol
    Roberto I Melendez
    Department of Psychology, Program in Psychobiology of Addictions, Purdue School of Science/IUPUI, 402 N. Blackford Street, Indianapolis, Indiana 46202-3275, USA
    Alcohol Clin Exp Res 26:318-25. 2002
    ..The findings also indicate that operant self-administration of ethanol is associated with increases in extracellular levels of dopamine in the NAc of P rats...
  85. ncbi The reinforcing effects of acetaldehyde in the posterior ventral tegmental area of alcohol-preferring rats
    Zachary A Rodd-Henricks
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, 791 Union Drive, Indianapolis, IN 46202 4887, USA
    Pharmacol Biochem Behav 72:55-64. 2002
    ..P rats maintained similar numbers of infusions and infusion patterns under both time-out schedules. Overall, the data indicate that ACD is a potent reinforcer within the posterior VTA of the P rat...
  86. ncbi Linkage disequilibrium between the beta frequency of the human EEG and a GABAA receptor gene locus
    Bernice Porjesz
    Department of Psychiatry, State University of New York, Health Science Center, Brooklyn, NY 11203, USA
    Proc Natl Acad Sci U S A 99:3729-33. 2002
    ..Uncovering the genes influencing brain oscillations provides a better understanding of the neural function involved in information processing...
  87. ncbi Involvement of acetaldehyde in alcohol addiction
    William J McBride
    Indiana University School of Medicine, Indianapolis, Indiana, USA
    Alcohol Clin Exp Res 26:114-9. 2002
    ..Smith; (3) The reinforcing actions of acetaldehyde in the ventral tegmental area, by Zachary A. Rodd-Henricks; and (4) Salsolinol and alcohol addiction, by William J. McBride...
  88. ncbi Binge drinking in Jewish and non-Jewish white college students
    Susan E Luczak
    University of California, San Diego, School of Medicine, USA
    Alcohol Clin Exp Res 26:1773-8. 2002
    ..More research is needed to identify additional factors, including other religious, cultural, genetic, and biological influences, that protect Jewish Americans from heavy drinking...
  89. ncbi Recent drinking history: association with family history of alcoholism and the acute response to alcohol during a 60 mg% clamp
    Vijay A Ramchandani
    Department of Medicine, Indiana University School of Medicine and The Roudeboush Veterans Affairs Medical Center, Indianapolis, Indiana 46202, USA
    J Stud Alcohol 63:734-44. 2002
    ..Although RDH was not associated with FHA in this study, it may be an important determinant of the response to alcohol...
  90. ncbi A comparative study on alcohol-preferring rat lines: effects of deprivation and stress phases on voluntary alcohol intake
    Valentina Vengeliene
    Department of Psychopharmacology, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Alcohol Clin Exp Res 27:1048-54. 2003
    ..For the alcohol drinking procedure, a long-term model of alcohol self-administration originally developed for heterogeneous Wistar rats was used and was compared with different alcohol-preferring rat lines...
  91. ncbi Innate differences in protein expression in the nucleus accumbens and hippocampus of inbred alcohol-preferring and -nonpreferring rats
    Frank A Witzmann
    Department of Cellular and Integrative Physiology, Biotechnology Research and Training Center, Indiana University School of Medicine, 1345 W 16th Street, Indianapolis, IN 46202, USA
    Proteomics 3:1335-44. 2003
    ....
  92. ncbi Effects of repeated alcohol deprivations on operant ethanol self-administration by alcohol-preferring (P) rats
    Zachary A Rodd
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Neuropsychopharmacology 28:1614-21. 2003
    ..The results suggest that repeated cycles of alcohol deprivation and alcohol access increased the reinforcing effects of ETOH in the P rats...
  93. ncbi Neuropeptide Y reduces oral ethanol intake in alcohol-preferring (P) rats following a period of imposed ethanol abstinence
    Nicholas W Gilpin
    Department of Psychology, Purdue School of Science, Indiana University-Purdue University Indianapolis, Indianapolis, IN 46202, USA
    Alcohol Clin Exp Res 27:787-94. 2003
    ..This effect of NPY compares favorably to results obtained with other treatments tested in similar animal models and provides support for a role of NPY in an allostasis model of addiction...
  94. ncbi alpha-Synuclein maps to a quantitative trait locus for alcohol preference and is differentially expressed in alcohol-preferring and -nonpreferring rats
    Tiebing Liang
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Proc Natl Acad Sci U S A 100:4690-5. 2003
    ..These results suggest that differential expression of the alpha-synuclein gene may contribute to alcohol preference in the iP rats...
  95. ncbi Salsolinol produces reinforcing effects in the nucleus accumbens shell of alcohol-preferring (P) rats
    Zachary A Rodd
    Indiana University School of Medicine, Institute of Psychiatric Research, 791 Union Drive, Indianapolis, IN 46202 4887, USA
    Alcohol Clin Exp Res 27:440-9. 2003
    ....
  96. ncbi Ethanol drinking experience attenuates (-)sulpiride-induced increases in extracellular dopamine levels in the nucleus accumbens of alcohol-preferring (P) rats
    Eric A Engleman
    Department of Psychology, Purdue School of Science, 402 N. Blackford Street, IUPUI, Indianapolis, IN 46202-3275, USA
    Alcohol Clin Exp Res 27:424-31. 2003
    ..05) than in the ethanol-drinking group. CONCLUSIONS: The findings are consistent with the hypothesis that ethanol-drinking experience causes a desensitization or a down-regulation of D(2) autoreceptors in the NAc of P rats...
  97. ncbi Ethanol effects on local cerebral glucose utilization in high-alcohol-drinking and low-alcohol-drinking rats
    Jennifer E Learn
    Program in Medical Neurobiology, Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, 791 Union Drive, Indianapolis, IN 46202-4887, USA
    Alcohol 29:1-9. 2003
    ..These findings may indicate that certain CNS regions of LAD-2 rats are more sensitive than regions of HAD-2 rats to the effects of low-to-intermediate doses of ethanol...
  98. ncbi High- and low-alcohol-preferring mice show differences in conditioned taste aversion to alcohol
    Julia A Chester
    Department of Medicine, Indiana University School of Medicine, Indianapolis, 462023, USA
    Alcohol Clin Exp Res 27:12-8. 2003
    ..The present findings indicate that common genes mediate both alcohol preference and the aversive effects of alcohol as measured in the CTA paradigm...
  99. ncbi Maintaining steady state arterial alcohol levels in rats by using a physiologically based pharmacokinetic model
    Sandra L Morzorati
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, 791 Union Drive, Indianapolis, IN 46202 4887, USA
    Alcohol 28:189-95. 2002
    ..The PBPK model-based method seems to be improved over the earlier method. Maintaining steady state AACs in rats is useful for studies in which fluctuating alcohol levels may confound experimental results...
  100. ncbi A pilot study of alcohol exposure and pharmacokinetics in women with or without children with fetal alcohol syndrome
    Nathaniel C O Khaole
    Foundation for Alcohol Related Research, University of Cape Town Medical School, Cape Town, South Africa
    Alcohol Alcohol 39:503-8. 2004
    ..To determine the alcohol exposure and pharmacokinetics of alcohol in a group of women who had given birth to children with FAS, compared with women who had not given birth to FAS children...
  101. ncbi Subjective intoxication in response to alcohol challenge: heritability and covariation with personality, breath alcohol level, and drinking history
    Richard J Viken
    Department of Psychology, Purdue School of Science, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202, USA
    Alcohol Clin Exp Res 27:795-803. 2003
    ..However, direct evidence for genetic effects on subjective response to alcohol is very limited...