Lang Li

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. ncbi request reprint CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment
    Yan Jin
    Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Natl Cancer Inst 97:30-9. 2005
  2. ncbi request reprint A hierarchical statistical model to assess the confidence of peptides and proteins inferred from tandem mass spectrometry
    Changyu Shen
    Division of Biostatistics, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Bioinformatics 24:202-8. 2008
  3. ncbi request reprint Drug-drug interaction prediction: a Bayesian meta-analysis approach
    Lang Li
    Division of Biostatistics, Department of Medicine, Indiana University, IN, USA
    Stat Med 26:3700-21. 2007
  4. pmc An integrated pharmacokinetics ontology and corpus for text mining
    Heng yi Wu
    Center for Computational Biology and Bioinformatics, School of Medicine, Indiana University, Indianapolis, IN, USA
    BMC Bioinformatics 14:35. 2013
  5. pmc CYP2D6 genotype and tamoxifen response
    James M Rae
    Breast Cancer Res 7:E6. 2005
  6. ncbi request reprint Estimation and inference for a spline-enhanced population pharmacokinetic model
    Lang Li
    Division of Biostatistics, Indiana University, Indianapolis 46202, USA
    Biometrics 58:601-11. 2002
  7. ncbi request reprint Epigenetic hypothesis tests for methylation and acetylation in a triple microarray system
    Lang Li
    Division of Biostatistics, Department of Medicine, Indiana University, Indianapolis, IN 46022, USA
    J Comput Biol 12:370-90. 2005
  8. ncbi request reprint A mixture model-based discriminate analysis for identifying ordered transcription factor binding site pairs in gene promoters directly regulated by estrogen receptor-alpha
    Lang Li
    Division of Biostatistics, Department of Medicine, Indiana University School of Medicine Indianapolis, IN 47405, USA
    Bioinformatics 22:2210-6. 2006
  9. pmc A mixture model approach in gene-gene and gene-environmental interactions for binary phenotypes
    Lang Li
    Division of Biostatistics, Department of Medicine, Indiana University, Indianapolis, Indiana46202, USA
    J Biopharm Stat 18:1150-77. 2008
  10. ncbi request reprint QT analysis: a complex answer to a 'simple' problem
    Lang Li
    Division of Biostatistics, Department of Medicine, Indiana University 46202 2678, USA
    Stat Med 23:2625-43. 2004

Collaborators

Detail Information

Publications78

  1. ncbi request reprint CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment
    Yan Jin
    Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Natl Cancer Inst 97:30-9. 2005
    ....
  2. ncbi request reprint A hierarchical statistical model to assess the confidence of peptides and proteins inferred from tandem mass spectrometry
    Changyu Shen
    Division of Biostatistics, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Bioinformatics 24:202-8. 2008
    ..Although many approaches have been developed to assign confidence measure from different perspectives, a unified statistical framework that integrates the uncertainty of peptides and proteins is still missing...
  3. ncbi request reprint Drug-drug interaction prediction: a Bayesian meta-analysis approach
    Lang Li
    Division of Biostatistics, Department of Medicine, Indiana University, IN, USA
    Stat Med 26:3700-21. 2007
    ..Sensitivity analysis is conducted to justify prior distribution selections...
  4. pmc An integrated pharmacokinetics ontology and corpus for text mining
    Heng yi Wu
    Center for Computational Biology and Bioinformatics, School of Medicine, Indiana University, Indianapolis, IN, USA
    BMC Bioinformatics 14:35. 2013
    ....
  5. pmc CYP2D6 genotype and tamoxifen response
    James M Rae
    Breast Cancer Res 7:E6. 2005
  6. ncbi request reprint Estimation and inference for a spline-enhanced population pharmacokinetic model
    Lang Li
    Division of Biostatistics, Indiana University, Indianapolis 46202, USA
    Biometrics 58:601-11. 2002
    ..The interpretation of PK parameters in the model and its flexibility are discussed. The proposed methods are illustrated by application to the data that motivated this article. The model's performance is evaluated through simulation...
  7. ncbi request reprint Epigenetic hypothesis tests for methylation and acetylation in a triple microarray system
    Lang Li
    Division of Biostatistics, Department of Medicine, Indiana University, Indianapolis, IN 46022, USA
    J Comput Biol 12:370-90. 2005
    ..001). Further simulations suggest that even if the constant variance and normality assumptions do not hold, the power of those two tests is robust...
  8. ncbi request reprint A mixture model-based discriminate analysis for identifying ordered transcription factor binding site pairs in gene promoters directly regulated by estrogen receptor-alpha
    Lang Li
    Division of Biostatistics, Department of Medicine, Indiana University School of Medicine Indianapolis, IN 47405, USA
    Bioinformatics 22:2210-6. 2006
    ....
  9. pmc A mixture model approach in gene-gene and gene-environmental interactions for binary phenotypes
    Lang Li
    Division of Biostatistics, Department of Medicine, Indiana University, Indianapolis, Indiana46202, USA
    J Biopharm Stat 18:1150-77. 2008
    ..The mixture model approach has the highest recovery probability to recover the true partition in the simulation studies. Its applications are exemplified in interim data analyses for two cancer studies...
  10. ncbi request reprint QT analysis: a complex answer to a 'simple' problem
    Lang Li
    Division of Biostatistics, Department of Medicine, Indiana University 46202 2678, USA
    Stat Med 23:2625-43. 2004
    ..1-0.2 ms). The two-step off-drug QT correction analysis is shown to be almost as efficient as our one-step off- and on-drug QT analysis...
  11. ncbi request reprint A population pharmacokinetic model with time-dependent covariates measured with errors
    Lang Li
    Division of Biostatistics, Indiana University, Indianapolis, Indiana 46254, USA
    Biometrics 60:451-60. 2004
    ..Our results show that the 2orderND method performs well, while the 2orderAD method can yield PK parameter estimators that are subject to considerable biases...
  12. doi request reprint Composite functional genetic and comedication CYP2D6 activity score in predicting tamoxifen drug exposure among breast cancer patients
    Silvana Borges
    Division of Biostatistics Clinical Pharmacology, Indiana University, School of Medicine, 410 W 10th St, HITS 3000, Indianapolis, IN 46202 e mail
    J Clin Pharmacol 50:450-8. 2010
    ..However, endoxifen phenotypes still varied substantially, even with incorporation of CYD2D6 genotype and inhibiting factors, suggesting that other, as yet unidentified factors must be involved in tamoxifen activation...
  13. doi request reprint Exploratory study evaluating the association of polymorphisms of angiogenesis genes with hot flashes
    Bryan P Schneider
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Breast Cancer Res Treat 116:543-9. 2009
    ..We evaluated the association between germline polymorphisms in genes important to angiogenesis and subjective reporting of hot flashes...
  14. pmc A modulated empirical Bayes model for identifying topological and temporal estrogen receptor α regulatory networks in breast cancer
    Changyu Shen
    Center for Computational Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    BMC Syst Biol 5:67. 2011
    ..Dynamic gene expression changes have been shown to characterize the breast cancer cell response to estrogens, the every molecular mechanism of which is still not well understood...
  15. ncbi request reprint Estimating a positive false discovery rate for variable selection in pharmacogenetic studies
    Lang Li
    Department of Medicine, Division of Biostatistics, Indiana University, Indianapolis, Indiana 46202, USA
    J Biopharm Stat 17:883-902. 2007
    ..Data analysis is illustrated with a pharmacogenetics example...
  16. pmc RNA polymerase II binding patterns reveal genomic regions involved in microRNA gene regulation
    Guohua Wang
    Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
    PLoS ONE 5:e13798. 2010
    ....
  17. ncbi request reprint Diverse gene expression and DNA methylation profiles correlate with differential adaptation of breast cancer cells to the antiestrogens tamoxifen and fulvestrant
    Meiyun Fan
    Medical Sciences, Indiana University School of Medicine, Bloomington, Indiana 47405, USA
    Cancer Res 66:11954-66. 2006
    ..Such knowledge of resistance-associated mechanisms could allow for identification of therapy targets and strategies for resensitization to these well-established antihormonal agents...
  18. ncbi request reprint Quantitative effect of CYP2D6 genotype and inhibitors on tamoxifen metabolism: implication for optimization of breast cancer treatment
    Silvana Borges
    Department of Medicine, Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, 46202, USA
    Clin Pharmacol Ther 80:61-74. 2006
    ..We conducted a prospective trial in 158 patients with breast cancer who were taking tamoxifen to further understand the effect of CYP2D6 genotype and concomitant medications on endoxifen plasma concentrations...
  19. pmc Physiologically based pharmacokinetic model of mechanism-based inhibition of CYP3A by clarithromycin
    Sara K Quinney
    Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Drug Metab Dispos 38:241-8. 2010
    ..Furthermore, this model framework can be applied to other mechanism-based inhibitors...
  20. pmc A Bayesian meta-analysis on published sample mean and variance pharmacokinetic data with application to drug-drug interaction prediction
    Menggang Yu
    Division of Biostatistics, Department of Medicine, School of Medicine, Indiana University, Indianapolis, Indiana 46023, USA
    J Biopharm Stat 18:1063-83. 2008
    ..Sensitivity analysis was conducted to investigate the influences of interaction PK parameters, such as the inhibition constant Ki, on the DDI prediction...
  21. ncbi request reprint Aberrant expression of CARM1, a transcriptional coactivator of androgen receptor, in the development of prostate carcinoma and androgen-independent status
    Heng Hong
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, University Hospital 3465, University Medical Center, 550 North University Boulevard, Indianapolis, IN 46202, USA
    Cancer 101:83-9. 2004
    ..It is involved in the regulation of the biologic functions of the AR. It remains to be determined whether CARM1 is involved in prostatic carcinogenesis...
  22. pmc The impact of glucocorticoid polymorphisms on markers of neonatal respiratory disease after antenatal betamethasone administration
    David M Haas
    Department of Obstetrics and Gynecology, the Indiana University School of Medicine, Indianapolis, IN, USA
    Am J Obstet Gynecol 208:215.e1-6. 2013
    ..The objective of the current study was to determine the impact of maternal and fetal single-nucleotide polymorphisms (SNPs) in key betamethasone pathways on respiratory outcomes that serve as markers for severity of disease...
  23. pmc Identification of transcription factor and microRNA binding sites in responsible to fetal alcohol syndrome
    Guohua Wang
    Division of Biostatistics Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    BMC Genomics 9:S19. 2008
    ..This suggests that disturbance of miRNA functions may contribute to the alcohol-induced developmental deficiencies...
  24. ncbi request reprint Association of polymorphisms of angiogenesis genes with breast cancer
    Bryan P Schneider
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Breast Cancer Res Treat 111:157-63. 2008
    ..We report our preliminary data evaluating the association of polymorphisms from seven genes known to influence angiogenesis with the likelihood of having breast cancer...
  25. pmc A dynamic time order network for time-series gene expression data analysis
    Pengyue Zhang
    Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    BMC Syst Biol 6:S9. 2012
    ..However, these genes would represent good candidate biomarkers...
  26. pmc A Poisson mixture model to identify changes in RNA polymerase II binding quantity using high-throughput sequencing technology
    Weixing Feng
    Division of Biostatistics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    BMC Genomics 9:S23. 2008
    ..However, only approximately 0.7% (172) genes displayed significant Pol II binding changes in E2-treated antiestrogen-resistant cells. These results show that a Poisson mixture model can be used to analyze ChIP-seq data...
  27. pmc An empirical Bayes model for gene expression and methylation profiles in antiestrogen resistant breast cancer
    Jaesik Jeong
    Department of Medicine Division of Biostatistics, Indiana University, Indianapolis, IN, USA
    BMC Med Genomics 3:55. 2010
    ....
  28. pmc A novel Gibbs maximum a posteriori (GMAP) approach on Bayesian nonlinear mixed-effects population pharmacokinetics (PK) models
    Seongho Kim
    Department of Medicine, Division of Biostatistics, School of Medicine, Indiana University, Indianapolis, Indiana 46032, USA
    J Biopharm Stat 19:700-20. 2009
    ..The performance of GMAP and various MCMC algorithms are compared through Midazolam data analysis and simulation...
  29. doi request reprint Independent influence of dietary protein on markers of kidney function and disease in obesity
    Allon N Friedman
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Kidney Int 78:693-7. 2010
    ..Hence, while dietary protein does modulate kidney parameters, it is unlikely to fully account for the elevations in GFR and proteinuria found in obesity...
  30. pmc Changes in gene expression during pegylated interferon and ribavirin therapy of chronic hepatitis C virus distinguish responders from nonresponders to antiviral therapy
    Milton W Taylor
    Department of Biology, Indiana University, Bloomington, IN 47401, USA
    J Virol 81:3391-401. 2007
    ..No specific regulatory gene could be identified as responsible for this global blunting or the racial differences...
  31. ncbi request reprint Loss of 14-3-3sigma in prostate cancer and its precursors
    Liang Cheng
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Clin Cancer Res 10:3064-8. 2004
    ..The role of 14-3-3sigma in prostatic carcinogenesis is uncertain...
  32. pmc Estrogen receptor genotypes influence hot flash prevalence and composite score before and after tamoxifen therapy
    Yan Jin
    Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    J Clin Oncol 26:5849-54. 2008
    ..We determined whether genetic polymorphisms in estrogen receptors (ESRs) alpha and beta (ESR1 and ESR2, respectively) are associated with tamoxifen-induced hot flashes...
  33. pmc Increased risk of vincristine neurotoxicity associated with low CYP3A5 expression genotype in children with acute lymphoblastic leukemia
    Akinbode Egbelakin
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Pediatr Blood Cancer 56:361-7. 2011
    ..We also found that vincristine neurotoxicity is less common in African-Americans (70% express CYP3A5) than in Caucasians. We test the hypothesis that CYP3A5 expressers experience less vincristine neuropathy than do CYP3A5 non-expressers...
  34. pmc Alteration of gene expression by alcohol exposure at early neurulation
    Feng C Zhou
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA
    BMC Genomics 12:124. 2011
    ..To explore the global gene expression changes which may underline these developmental defects, microarray analyses were performed in a whole embryo mouse culture model that allows control over alcohol and embryonic variables...
  35. ncbi request reprint Endoxifen, a secondary metabolite of tamoxifen, and 4-OH-tamoxifen induce similar changes in global gene expression patterns in MCF-7 breast cancer cells
    Young Chai Lim
    Division of Clinical Pharmacology, Indiana University School of Medicine, 1001 West 10th Street, WD Myers Bldg, W7123, Indianapolis, IN 46202, USA
    J Pharmacol Exp Ther 318:503-12. 2006
    ..We conclude that endoxifen and 4-OH-Tam have similar effects on global gene expression patterns in MCF-7 cells and that the majority of the affected genes are estrogen-regulated genes...
  36. ncbi request reprint Computational approaches that predict metabolic intermediate complex formation with CYP3A4 (+b5)
    David R Jones
    Indiana University School of Medicine, Department of Medicine, Division of Clinical Pharmacology, Wishard Memorial Hospital, Myers Bldg W7123, Indianapolis, IN 46220, USA
    Drug Metab Dispos 35:1466-75. 2007
    ..The preliminary pharmacophores provide structural insights that complement those for CYP3A4 inhibitors and substrates...
  37. pmc Elevated expression of cancer-associated proliferating cell nuclear antigen in high-grade prostatic intraepithelial neoplasia and prostate cancer
    Xiaoyan Wang
    Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Prostate 71:748-54. 2011
    ..The expression and potential utility of this marker in prostatic neoplasia is uncertain. With the development of this new caPCNA selective antibody, we explored the potential utility of this marker in prostate cancer...
  38. pmc Enriched transcription factor binding sites in hypermethylated gene promoters in drug resistant cancer cells
    Meng Li
    Medical Sciences, School of Medicine, Indiana University, Bloomington, IN 47404, USA
    Bioinformatics 24:1745-8. 2008
    ..In summary, we believe that these.ndings offer a means to further explore the relationship between DNA methylation and gene expression in drug resistance and tumorigenesis...
  39. pmc A modulator based regulatory network for ERα signaling pathway
    Heng yi Wu
    Center for Computational Biology and Bioinformatics, Indiana University, Indianapolis, IN, USA
    BMC Genomics 13:S6. 2012
    ..ERα requires distinct co-regulator or modulators for efficient transcriptional regulation, and they form a regulatory network. Knowing this regulatory network will enable systematic study of the effect of ERα on breast cancer...
  40. pmc Literature mining on pharmacokinetics numerical data: a feasibility study
    Zhiping Wang
    Division of Biostatistics, Department of Medicine, School of Medicine, Indiana University, 410 West 10th Street, Suite 3044, Indianapolis, IN 46202, USA
    J Biomed Inform 42:726-35. 2009
    ..It greatly out-performs a conventional data mining approach (support vector machine), which has an F-score of 68.1%. Further investigate on 7 more drugs reveals comparable performances of our sequential mining approach...
  41. pmc Comparison of changes in the lipid profile of postmenopausal women with early stage breast cancer treated with exemestane or letrozole
    Lauren Nicole Bell
    Division of Clinical Pharmacology, Wishard Memorial Hospital, WD Myers Bldg, W7123, 1001 West 10th St, Indianapolis, IN 46202, USA
    J Clin Pharmacol 52:1852-60. 2012
    ..In conclusion, AI treatment and/or washout of tamoxifen induced detrimental changes in the lipid profile of postmenopausal women with breast cancer...
  42. pmc A phase 1 and pharmacodynamic study of decitabine in combination with carboplatin in patients with recurrent, platinum-resistant, epithelial ovarian cancer
    Fang Fang
    Medical Sciences Program, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Cancer 116:4043-53. 2010
    ....
  43. pmc Alt Event Finder: a tool for extracting alternative splicing events from RNA-seq data
    Ao Zhou
    Bioinformatics Program, School of Informatics, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202, USA
    BMC Genomics 13:S10. 2012
    ..Identifying alternative splicing events from RNA-seq experiments is important for understanding the diversity of transcripts and for investigating the regulation of splicing...
  44. pmc Using RNase sequence specificity to refine the identification of RNA-protein binding regions
    Xin Wang
    Division of Biostatistics Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    BMC Genomics 9:S17. 2008
    ..We present two regions to which multiple amplicons map as examples to demonstrate this approach...
  45. pmc Rapid identification of the hepatic cytochrome P450 2C19 activity using a novel and noninvasive [13C]pantoprazole breath test
    Zeruesenay Desta
    Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Pharmacol Exp Ther 329:297-305. 2009
    ..74; p = 0.038). These feasibility data suggest that the [(13)C]pantoprazole breath test is a reliable, rapid, and noninvasive probe of CYP2C19 and seems to be a useful tool to optimize drug therapy metabolized by CYP2C19...
  46. pmc Prediction of postoperative recurrence-free survival in non-small cell lung cancer by using an internationally validated gene expression model
    Ranjana Mitra
    Division of Hematology, Department of Medicine, School of Public Health, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Clin Cancer Res 17:2934-46. 2011
    ....
  47. pmc The impact of drug metabolizing enzyme polymorphisms on outcomes after antenatal corticosteroid use
    David M Haas
    the Indiana University School of Medicine, Indianapolis, IN, USA
    Am J Obstet Gynecol 206:447.e17-24. 2012
    ..To determine the impact of maternal and fetal single nucleotide polymorphisms in key betamethasone pathways on neonatal outcomes...
  48. pmc In silico and in vitro identification of microRNAs that regulate hepatic nuclear factor 4α expression
    Anuradha Ramamoorthy
    Department of Medicine, Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Drug Metab Dispos 40:726-33. 2012
    ..16). In conclusion, our findings demonstrate strong evidence for a role of miRNAs in the regulation of HNF4A...
  49. pmc Pharmacotherapy and pregnancy: highlights from the Second International Conference for Individualized Pharmacotherapy in Pregnancy
    David M Haas
    Indiana University School of Medicine, PREGMED, The Indiana University Center for Pharmacogenetics and Therapeutics Research in Maternal and Child Health, Indiana, USA
    Clin Transl Sci 2:439-43. 2009
    ....
  50. pmc A penalized mixture model approach in genotype/phenotype association analysis for quantitative phenotypes
    Lang Li
    Division of Biostatistics, Department of Medicine, School of Medicine, Indiana University, Indianapolis, IN
    Cancer Inform 9:93-103. 2010
    ..The power and recovery rate of the true partition for the mixture model approach are investigated in statistical simulation studies, where it outperforms another published method...
  51. ncbi request reprint PC cell-derived growth factor expression in prostatic intraepithelial neoplasia and prostatic adenocarcinoma
    Chong Xian Pan
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Clin Cancer Res 10:1333-7. 2004
    ..It is a novel growth factor that stimulates cell proliferation, confers epithelial tumorigenesis, and promotes tumor invasion. Here we investigate the potential of PCDGF as a therapeutic target for prostate cancer...
  52. doi request reprint Differential gene expression profiling of esophageal adenocarcinoma
    Zane T Hammoud
    Department of Surgery, Thoracic Surgery Division, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Thorac Cardiovasc Surg 137:829-34. 2009
    ....
  53. ncbi request reprint Constitutional polymorphisms of prostate cancer: prognostic and diagnostic implications
    Noah M Hahn
    Indiana University Melvin and Bren Simon Cancer Center, Indiana Cancer Pavilion Room RT415, 535 Barnhill Drive, Indianapolis, Indiana 46202, USA
    Future Oncol 3:665-82. 2007
    ....
  54. pmc Variability of heart rate correction methods for the QT interval
    Mehul Desai
    Division of Clinical Pharmacology, Department of Medicine, Indiana University, Indianapolis, IN, USA, and Department of Cardiological Sciences, St George s Hospital Medical School, London, UK
    Br J Clin Pharmacol 55:511-7. 2003
    ..To compare variability of heart rate-corrected QT intervals (QTc) using three different methods in a study of low-dose oral haloperidol...
  55. ncbi request reprint Hoosier Oncology Group randomized phase II study of docetaxel, vinorelbine, and estramustine in combination in hormone-refractory prostate cancer with pharmacogenetic survival analysis
    Noah M Hahn
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Clin Cancer Res 12:6094-9. 2006
    ..To determine the safety and efficacy of two docetaxel doublets in hormone-refractory prostate cancer (HRPC) patients and to examine the prognostic role of polymorphisms in host genes important to docetaxel metabolism and transport...
  56. ncbi request reprint Heterogeneity of Gleason grade in multifocal adenocarcinoma of the prostate
    Rebecca Arora
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Cancer 100:2362-6. 2004
    ..The current study was undertaken to compare the Gleason grades of individual adenocarcinoma foci in a given specimen with the overall Gleason grades (primary and secondary) of that specimen...
  57. pmc Non-compartment model to compartment model pharmacokinetics transformation meta-analysis--a multivariate nonlinear mixed model
    Zhiping Wang
    Division of Biostatistics, Department of Medicine, School of Medicine, Indiana University, Indianapolis, IN 46032, USA
    BMC Syst Biol 4:S8. 2010
    ..This meta-analysis was performed with a multivariate nonlinear mixed model. A conditional first-order linearization approach was developed for statistical estimation and inference...
  58. ncbi request reprint Nuclear factor-kappaB is constitutively activated in prostate cancer in vitro and is overexpressed in prostatic intraepithelial neoplasia and adenocarcinoma of the prostate
    Christopher Sweeney
    Department of Medicine, Indiana University, Indianapolis, Indiana 46202, USA
    Clin Cancer Res 10:5501-7. 2004
    ..The transcription factor nuclear factor-kappaB (NF-kappaB) promotes the production of angiogenic, antiapoptotic, and prometastatic factors that are involved in carcinogenesis...
  59. ncbi request reprint A phase I, pharmacokinetic and pharmacodynamic dose escalation trial of weekly paclitaxel with interferon-alpha2b in patients with solid tumors
    Bryan Schneider
    Division of Hematology Oncology, Department of Medicine, Indiana University, Indianapolis, IN 46202, USA
    Cancer Chemother Pharmacol 59:261-8. 2007
    ..The toxicity, pharmacokinetics, and pharmacodynamics of paclitaxel with interferon-alpha2b (IFN-alpha2b) were assessed in patients with solid tumors to assess the feasibility of this novel anti-angiogenic regimen...
  60. ncbi request reprint Impact of CYP2B6 polymorphism on hepatic efavirenz metabolism in vitro
    Zeruesenay Desta
    Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, 1001 West 10th Street, WD Myers Bldg, W7123, Indianapolis, IN 46202, USA
    Pharmacogenomics 8:547-58. 2007
    ..To determine the influence of cytochrome P450 2B6 (CYP2B6) genotype on the rate of oxidative efavirenz metabolism in human liver microsomes...
  61. ncbi request reprint Dextromethorphan to dextrorphan urinary metabolic ratio does not reflect dextromethorphan oral clearance
    Silvana Borges
    Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Drug Metab Dispos 33:1052-5. 2005
    ..Considering the required sample size and the low correlation with oral clearance, urinary metabolic ratio is not recommended as the primary outcome variable in studies requiring the detection of modest changes in CYP2D6 activity...
  62. ncbi request reprint Analysis of angiogenesis genes from paraffin-embedded breast tumor and lymph nodes
    Bryan P Schneider
    Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA
    Breast Cancer Res Treat 96:209-15. 2006
    ..These genes include vascular endothelial growth factor (VEGF) and endothelial nitric oxide synthase (eNOS)...
  63. pmc Effects of HIV protease inhibitor ritonavir on Akt-regulated cell proliferation in breast cancer
    Anjaiah Srirangam
    Department of Medicine, Indiana University, Indianapolis, Indiana 46202, USA
    Clin Cancer Res 12:1883-96. 2006
    ..Ritonavir may be of interest for breast cancer therapeutics and its efficacy may be increased by sustained exposure or Hsp90 RNA interference...
  64. pmc Dysregulated immune profiles for skin and dendritic cells are associated with increased host susceptibility to Haemophilus ducreyi infection in human volunteers
    Tricia L Humphreys
    Department of Medicine, Indiana University, Indianapolis, IN 46202, USA
    Infect Immun 75:5686-97. 2007
    ..ducreyi. PP DC may promote a dysregulated T-cell response that contributes to phagocytic failure, while RR DC may promote a Th1 response that facilitates bacterial clearance...
  65. ncbi request reprint Association between the CYP3A5 genotype and blood pressure
    Herbert Ho
    Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, 1001 W Tenth St, WD Myers Room W7123, Indianapolis, IN 46202, USA
    Hypertension 45:294-8. 2005
    ..We conclude that although untreated blood pressure may be higher in blacks with the CYP3A5*3/*3 genotype, the CYP3A5*1 allele may be associated with hypertension that is more refractory to treatment in this ethnic group...
  66. doi request reprint Trends in mortality from cancers of the breast, colon, prostate, esophagus, and stomach in East Asia: role of nutrition transition
    Jianjun Zhang
    Division of Epidemiology, Department of Public Health, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Eur J Cancer Prev 21:480-9. 2012
    ....
  67. pmc Molecular analysis of thymoma
    Sunil Badve
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
    PLoS ONE 7:e42669. 2012
    ..A number of potential candidates for therapeutics were also identified...
  68. ncbi request reprint Effect of cirrhosis and liver transplantation on the gender difference in QT interval
    Adegboyega Q Adigun
    Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Am J Cardiol 95:691-4. 2005
    ..The study showed that (1) physiologic gender difference in the QTc interval is abolished in cirrhosis, and it is not restored after liver transplantation, and (2) gender hormone concentrations had no effect on the QTc interval...
  69. ncbi request reprint The amino terminus of the human multidrug resistance transporter ABCC1 has a U-shaped folding with a gating function
    Qun Chen
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 281:31152-63. 2006
    ..We also found that this U-shaped amino terminus probably functions as a gate to regulate the drug transport activity of human ABCC1...
  70. ncbi request reprint Differential gene induction by type I and type II interferons and their combination
    Corneliu Sanda
    Department of Biology, Indiana University, Bloomington, IN 47405, USA
    J Interferon Cytokine Res 26:462-72. 2006
    ..Elevated induction of many of these genes may be sufficient to explain the synergistic antiviral and antitumor effects of this combination of IFNs in vivo...
  71. ncbi request reprint A statistical framework to discover true associations from multiprotein complex pull-down proteomics data sets
    Changyu Shen
    Division of Biostatistics, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Proteins 64:436-43. 2006
    ..3%. Cross-examination of our results with protein complexes confirmed by various experimental techniques demonstrates that many true associations that cannot be identified by previous approach are identified by our method...
  72. pmc Measuring the glomerular filtration rate in obese individuals without overt kidney disease
    Allon N Friedman
    Division of Nephrology, Indiana University School of Medicine, Indianapolis, Ind, USA
    Nephron Clin Pract 116:c224-34. 2010
    ..Identifying methods to accurately measure the glomerular filtration rate (GFR) in obese individuals without kidney overt kidney disease is necessary to understanding the pathophysiology and natural history of obesity-related kidney disease...
  73. ncbi request reprint Selecting pre-screening items for early intervention trials of dementia--a case study
    Lang Li
    Division of Biostatistics, Indiana University School of Medicine, 1050 Wishard Boulevard, RG4, Indianapolis, IN 46202, USA
    Stat Med 23:271-83. 2004
    ..Using the boosting option for decision trees did not substantially improve the performance. We recommend that for each situation, different methods of classification should be attempted to obtain optimal results for a given purpose...
  74. pmc High-level expression of EphA2 receptor tyrosine kinase in prostatic intraepithelial neoplasia
    Guangyuan Zeng
    Departments of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Am J Pathol 163:2271-6. 2003
    ..Moreover, the presence of high levels of EphA2 in these cells suggests opportunities for prostate cancer prevention and treatment...
  75. pmc Aripiprazole in pervasive developmental disorder not otherwise specified and Asperger's disorder: a 14-week, prospective, open-label study
    Kimberly A Stigler
    Department of Psychiatry, Section of Child and Adolescent Psychiatry, Indiana University School of Medicine and Christian Sarkine Autism Treatment Center, James Whitcomb Riley Hospital for Children, Indianapolis, Indiana 46202 5200, USA
    J Child Adolesc Psychopharmacol 19:265-74. 2009
    ..The aim of this study was to determine the effectiveness and tolerability of aripiprazole for irritability in pervasive developmental disorder not otherwise specified (PDD-NOS) and Asperger's disorder...
  76. pmc Diabetes mellitus increases the in vivo activity of cytochrome P450 2E1 in humans
    Zaiqi Wang
    Department of Medicine, Division of Clinical Pharmacology, Indiana University School of Medicine, Wishard Memorial Hospital, OPW 320, Indianapolis IN, USA
    Br J Clin Pharmacol 55:77-85. 2003
    ..This study was designed to test the hypothesis that human diabetics experience enhanced CYP2E1 expression...
  77. ncbi request reprint Prognostic DNA methylation biomarkers in ovarian cancer
    Susan H Wei
    Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA
    Clin Cancer Res 12:2788-94. 2006
    ..Correspondingly, distinct combinations of methylated loci can function as biomarkers for numerous clinical correlates of ovarian and other cancers...
  78. pmc Prospective characterization of musculoskeletal symptoms in early stage breast cancer patients treated with aromatase inhibitors
    N Lynn Henry
    University of Michigan Comprehensive Cancer Center, Ann Arbor, MI 48109 0942, USA
    Breast Cancer Res Treat 111:365-72. 2008
    ..AIs are commonly associated with musculoskeletal symptoms. The primary objective of this study was to describe the musculoskeletal symptoms that developed in the first 100 subjects enrolled who had at least 6 months follow-up...

Research Grants5

  1. Bayesian Tools for PBPK Models in Drug Interaction Res.
    Lang Li; Fiscal Year: 2007
    ..Hence, a CYP3A specific inhibitor-substrate combination, ketoconazole-midazolam, is chosen as a starting example. It will serve as a building block for multi-enzyme and multi-drug based DDI PBPK models. ..
  2. Bayesian Tools for PBPK Models in Drug Interaction Research
    Lang Li; Fiscal Year: 2009
    ..Hence, a CYP3A specific inhibitor-substrate combination, ketoconazole-midazolam, is chosen as a starting example. It will serve as a building block for multi-enzyme and multi-drug based DDI PBPK models. ..