Xianyin Lai

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. pmc Issues and applications in label-free quantitative mass spectrometry
    Xianyin Lai
    Department of Cellular and Integrative Physiology, Biotechnology Research and Training Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Int J Proteomics 2013:756039. 2013
  2. pmc Reproducible method to enrich membrane proteins with high purity and high yield for an LC-MS/MS approach in quantitative membrane proteomics
    Xianyin Lai
    Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Electrophoresis 34:809-17. 2013
  3. pmc A novel alignment method and multiple filters for exclusion of unqualified peptides to enhance label-free quantification using peptide intensity in LC-MS/MS
    Xianyin Lai
    Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana 46202, United States
    J Proteome Res 10:4799-812. 2011
  4. pmc Alterations in the aqueous humor proteome in patients with a glaucoma shunt device
    Arundhati Anshu
    Price Vision Group, Indianapolis, IN, USA
    Mol Vis 17:1891-900. 2011
  5. pmc Novel serum biomarkers for detection of excessive alcohol use
    Suthat Liangpunsakul
    Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana Roudebush Veterans Administration Medical Center, Indianapolis, Indiana
    Alcohol Clin Exp Res 39:556-65. 2015
  6. pmc Proteomic study of low-temperature responses in strawberry cultivars (Fragaria x ananassa) that differ in cold tolerance
    Gage Koehler
    Department of Biology, Indiana University Purdue University, Indianapolis, Indiana 46202, USA
    Plant Physiol 159:1787-805. 2012
  7. pmc Alterations in the aqueous humor proteome in patients with Fuchs endothelial corneal dystrophy
    Matthew R Richardson
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46260, USA
    Mol Vis 16:2376-83. 2010
  8. pmc Differential expression of renal proteins in a rodent model of Meckel syndrome
    Stephen B Mason
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, USA
    Nephron Exp Nephrol 117:e31-8. 2011
  9. pmc Increasing serum pre-adipocyte factor-1 (Pref-1) correlates with decreased body fat, increased free fatty acids, and level of recent alcohol consumption in excessive alcohol drinkers
    Suthat Liangpunsakul
    Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA Roudebush Veterans Administration Medical Center, Indianapolis, IN, USA Electronic address
    Alcohol 48:795-800. 2014
  10. pmc Ethanol exposure alters protein expression in a mouse model of fetal alcohol spectrum disorders
    Stephen Mason
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Int J Proteomics 2012:867141. 2012

Collaborators

  • Mu Wang
  • Suthat Liangpunsakul
  • Francis W Price
  • Walter C Hubbard
  • Zhangsheng Yu
  • Irina Petrache
  • Yehia Mechref
  • Jens Rohloff
  • Vincent H Gattone
  • Haixu Tang
  • Johnathan D Tune
  • Frank A Witzmann
  • Matthew R Richardson
  • Mervin C Yoder
  • Kelly S Schweitzer
  • Meredith Kohr Owen
  • Kelly L Prince
  • Stephen Mason
  • Kanokporn Noy Rithidech
  • Jin Sam You
  • Gage Koehler
  • Heather N Ringham
  • Arundhati Anshu
  • Stephen B Mason
  • Zaneer M Segu
  • Marianne O Price
  • Sarah Law
  • Elena S Kim
  • Clinton J Carroll
  • Mary Van Demark
  • Matthew J Justice
  • Steven X Chen
  • Christophe Poirier
  • John Goodpaster
  • Bruce D Ray
  • Robert Bittman
  • William D Kranz
  • Soyoung Park
  • Mikaela L McKenney
  • Michael Sturek
  • Zachary C Berwick
  • Mouhamad Alloosh
  • Steven P Moberly
  • Simon J Rhodes
  • Stephanie C Colvin
  • John V Goodpaster
  • Paiboon Reungpatthanaphong
  • Muath Alsheikh
  • Feng C Zhou
  • Louise Honikel
  • Robert C Wilson
  • Anita S√łnsteby
  • Stephen K Randall
  • Bruce Anthony
  • Peter C Harris
  • Robert L Bacallao

Detail Information

Publications18

  1. pmc Issues and applications in label-free quantitative mass spectrometry
    Xianyin Lai
    Department of Cellular and Integrative Physiology, Biotechnology Research and Training Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Int J Proteomics 2013:756039. 2013
    ....
  2. pmc Reproducible method to enrich membrane proteins with high purity and high yield for an LC-MS/MS approach in quantitative membrane proteomics
    Xianyin Lai
    Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Electrophoresis 34:809-17. 2013
    ..In summary, the developed method is reproducible, produces a highly pure membrane fraction, and generates a high yield of membrane proteins...
  3. pmc A novel alignment method and multiple filters for exclusion of unqualified peptides to enhance label-free quantification using peptide intensity in LC-MS/MS
    Xianyin Lai
    Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana 46202, United States
    J Proteome Res 10:4799-812. 2011
    ..Further assessment was made by comparing mass spectrometric results to immunodetection, and consistent results were obtained. The new approach has novel and specific features enabling accurate label-free quantification...
  4. pmc Alterations in the aqueous humor proteome in patients with a glaucoma shunt device
    Arundhati Anshu
    Price Vision Group, Indianapolis, IN, USA
    Mol Vis 17:1891-900. 2011
    ..To investigate whether implantation of a glaucoma shunt device leads to inappropriate accumulation of plasma derived proteins in the aqueous humor...
  5. pmc Novel serum biomarkers for detection of excessive alcohol use
    Suthat Liangpunsakul
    Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana Roudebush Veterans Administration Medical Center, Indianapolis, Indiana
    Alcohol Clin Exp Res 39:556-65. 2015
    ..Excessive drinking has been shown to affect several organ systems, which may be reflected in changes in quantity of plasma proteins. Our aim was to employ novel proteomic analyses to identify potential markers for excessive alcohol use...
  6. pmc Proteomic study of low-temperature responses in strawberry cultivars (Fragaria x ananassa) that differ in cold tolerance
    Gage Koehler
    Department of Biology, Indiana University Purdue University, Indianapolis, Indiana 46202, USA
    Plant Physiol 159:1787-805. 2012
    ..The molecular basis for 'Jonsok'-enhanced cold tolerance can be explained by the constitutive level of a number of proteins that provide a physiological stress-tolerant poise...
  7. pmc Alterations in the aqueous humor proteome in patients with Fuchs endothelial corneal dystrophy
    Matthew R Richardson
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46260, USA
    Mol Vis 16:2376-83. 2010
    ..This is the first report indicating alterations in the AH proteome with FECD, and taken together this study suggests several novel hypotheses regarding AH proteins role in FECD pathogenesis...
  8. pmc Differential expression of renal proteins in a rodent model of Meckel syndrome
    Stephen B Mason
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, USA
    Nephron Exp Nephrol 117:e31-8. 2011
    ..Renal protein misexpression was evaluated in the Wpk rat model of human MKS3 gene disease to identify biomarkers for the staging of renal cystic progression...
  9. pmc Increasing serum pre-adipocyte factor-1 (Pref-1) correlates with decreased body fat, increased free fatty acids, and level of recent alcohol consumption in excessive alcohol drinkers
    Suthat Liangpunsakul
    Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA Roudebush Veterans Administration Medical Center, Indianapolis, IN, USA Electronic address
    Alcohol 48:795-800. 2014
    ..Further work is needed to validate these findings and to better understand the role of Pref-1 and its clinical significance in subjects with heavy alcohol use. ..
  10. pmc Ethanol exposure alters protein expression in a mouse model of fetal alcohol spectrum disorders
    Stephen Mason
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Int J Proteomics 2012:867141. 2012
    ..Using a whole-embryo culture, we have identified misregulated proteins known to be involved in nervous system development and function...
  11. pmc Venous and arterial endothelial proteomics: mining for markers and mechanisms of endothelial diversity
    Matthew R Richardson
    Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Expert Rev Proteomics 7:823-31. 2010
    ..It is the purpose of this article to account for the diversity of vascular EC proteomic investigations and comment on the issues that have been and should be addressed in future work...
  12. pmc Proteomic profiling of human sera for discovery of potential biomarkers to monitor abstinence from alcohol abuse
    Xianyin Lai
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, IN, USA Department of Cellular and Integrative Physiology, Indiana University School of Medicine, IN, USA
    Electrophoresis 36:556-63. 2015
    ..In summary, several new biomarker candidates have been identified to monitor abstinence from alcohol abuse...
  13. pmc Perivascular adipose tissue potentiates contraction of coronary vascular smooth muscle: influence of obesity
    Meredith Kohr Owen
    Department of Cellular and Integrative Physiology, Indiana University School of Medicine, 635 Barnhill Dr, Indianapolis, IN 46202, USA
    Circulation 128:9-18. 2013
    ..This investigation examined the mechanisms by which coronary perivascular adipose tissue (PVAT)-derived factors influence vasomotor tone and the PVAT proteome in lean versus obese swine...
  14. pmc A proteomic workflow for discovery of serum carrier protein-bound biomarker candidates of alcohol abuse using LC-MS/MS
    Xianyin Lai
    Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Electrophoresis 30:2207-14. 2009
    ..Altered abundance of these proteins suggests that they may be potential novel biomarkers for alcohol abuse...
  15. pmc Developmental analysis and influence of genetic background on the Lhx3 W227ter mouse model of combined pituitary hormone deficiency disease
    Kelly L Prince
    Departments of Cellular and Integrative Physiology, Indiana University Purdue University, Indianapolis, IN 46202, USA
    Endocrinology 154:738-48. 2013
    ..Furthermore, as is noted in human disease, genetic background significantly impacts the phenotypic outcome of these monogenic endocrine diseases...
  16. pmc Identification of proteins secreted into the medium by human lymphocytes irradiated in vitro with or without adaptive environments
    Kanokporn Noy Rithidech
    Pathology Department, BHS T9, Stony Brook University, Stony Brook, NY 11794 8691, USA
    Health Phys 102:39-53. 2012
    ..Hence, these studies are highly relevant to radiation protection due to an increased use of low dose radiation in daily life (e.g., medical diagnosis or airport safety) or an unavoidable exposure to low level background radiation...
  17. pmc Proteomic profiling of halloysite clay nanotube exposure in intestinal cell co-culture
    Xianyin Lai
    Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN, USA
    J Appl Toxicol 33:1316-29. 2013
    ..These potentially relevant functional effects warrant further investigation in in vivo models and suggest that chronic or bolus occupational exposure to halloysite nanotubes may have unintended outcomes...
  18. pmc Endothelial disruptive proinflammatory effects of nicotine and e-cigarette vapor exposures
    Kelly S Schweitzer
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana
    Am J Physiol Lung Cell Mol Physiol 309:L175-87. 2015
    ..These results suggest that soluble components of e-Cig, including nicotine, cause dose-dependent loss of lung endothelial barrier function, which is associated with oxidative stress and brisk inflammation. ..