Daniel L Koller

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. pmc Genetic loci affecting bone structure and strength in inbred COP and DA rats
    Qiwei Sun
    Department of Biomedical Engineering, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Bone 42:547-53. 2008
  2. pmc Meta-analysis of genome-wide studies identifies WNT16 and ESR1 SNPs associated with bone mineral density in premenopausal women
    Daniel L Koller
    Indiana University School of Medicine, Indianapolis, IN, USA
    J Bone Miner Res 28:547-58. 2013
  3. ncbi request reprint Genome screen for bone mineral density phenotypes in Fisher 344 and Lewis rat strains
    Daniel L Koller
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, 975 West Walnut Street, IB 130, Indianapolis, Indiana, 46202, USA
    Mamm Genome 16:578-86. 2005
  4. pmc Epistasis between QTLs for bone density variation in Copenhagen x dark agouti F2 rats
    Daniel L Koller
    Department of Medical and Molecular Genetics, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202, USA
    Mamm Genome 20:180-6. 2009
  5. pmc Genome-wide association study of bone mineral density in premenopausal European-American women and replication in African-American women
    Daniel L Koller
    Departments of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Clin Endocrinol Metab 95:1802-9. 2010
  6. ncbi request reprint Contribution of the LRP5 gene to normal variation in peak BMD in women
    Daniel L Koller
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Bone Miner Res 20:75-80. 2005
  7. ncbi request reprint False positive rates in association studies as a function of degree of stratification
    Daniel L Koller
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202 5251, USA
    J Bone Miner Res 19:1291-5. 2004
  8. pmc Epistatic effects contribute to variation in BMD in Fischer 344 x Lewis F2 rats
    Daniel L Koller
    Department of Medical and Molecular Genetics, Indiana University, Purdue University Indianapolis, Indianapolis, Indiana, USA
    J Bone Miner Res 23:41-7. 2008
  9. pmc Linkage screen for BMD phenotypes in male and female COP and DA rat strains
    Daniel L Koller
    Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana 46202, USA
    J Bone Miner Res 23:1382-8. 2008
  10. pmc Differentially expressed genes strongly correlated with femur strength in rats
    Imranul Alam
    Department of Biomedical Engineering, Indiana University Purdue University Indianapolis IUPUI, Indianapolis, IN 46202 5251, USA
    Genomics 94:257-62. 2009

Detail Information

Publications43

  1. pmc Genetic loci affecting bone structure and strength in inbred COP and DA rats
    Qiwei Sun
    Department of Biomedical Engineering, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Bone 42:547-53. 2008
    ..Our study demonstrates strong evidence of linkage for bone structure and strength to multiple rat chromosomes...
  2. pmc Meta-analysis of genome-wide studies identifies WNT16 and ESR1 SNPs associated with bone mineral density in premenopausal women
    Daniel L Koller
    Indiana University School of Medicine, Indianapolis, IN, USA
    J Bone Miner Res 28:547-58. 2013
    ..These data support the hypothesis that variants in these genes of known skeletal function also affect BMD during the premenopausal period...
  3. ncbi request reprint Genome screen for bone mineral density phenotypes in Fisher 344 and Lewis rat strains
    Daniel L Koller
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, 975 West Walnut Street, IB 130, Indianapolis, Indiana, 46202, USA
    Mamm Genome 16:578-86. 2005
    ..0. The region on rat Chromosome 8 is syntenic to human Chromosome 15, where linkage to spine and femur BMD has been previously reported and confirmed in a sample of premenopausal women...
  4. pmc Epistasis between QTLs for bone density variation in Copenhagen x dark agouti F2 rats
    Daniel L Koller
    Department of Medical and Molecular Genetics, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202, USA
    Mamm Genome 20:180-6. 2009
    ..These results provide new information regarding the mode of action of previously identified QTL in the rat, as well as identifying novel loci that act in combination with known QTL or with other novel loci to contribute to BMD variation...
  5. pmc Genome-wide association study of bone mineral density in premenopausal European-American women and replication in African-American women
    Daniel L Koller
    Departments of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Clin Endocrinol Metab 95:1802-9. 2010
    ..Several genome-wide association studies (GWAS) have been performed to identify genes contributing to bone mineral density (BMD), typically in samples of elderly women and men...
  6. ncbi request reprint Contribution of the LRP5 gene to normal variation in peak BMD in women
    Daniel L Koller
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Bone Miner Res 20:75-80. 2005
    ..Association between SNPs in LRP5 and hip and spine BMD was measured in 1301 premenopausal women. Only a small proportion of the BMD variation was attributable to LRP5 in our sample...
  7. ncbi request reprint False positive rates in association studies as a function of degree of stratification
    Daniel L Koller
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202 5251, USA
    J Bone Miner Res 19:1291-5. 2004
    ..The rate of positive results doubled as the proportion of stratification increased, showing the importance of controlling for stratification in association studies...
  8. pmc Epistatic effects contribute to variation in BMD in Fischer 344 x Lewis F2 rats
    Daniel L Koller
    Department of Medical and Molecular Genetics, Indiana University, Purdue University Indianapolis, Indianapolis, Indiana, USA
    J Bone Miner Res 23:41-7. 2008
    ..Several significant interactions were identified, involving both previously identified and novel QTLs...
  9. pmc Linkage screen for BMD phenotypes in male and female COP and DA rat strains
    Daniel L Koller
    Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana 46202, USA
    J Bone Miner Res 23:1382-8. 2008
    ..These results confirm that the genetic influence on BMD in the rat model is quite complex and would seem to be influenced by a number of different genes, some of which have sex-specific effects...
  10. pmc Differentially expressed genes strongly correlated with femur strength in rats
    Imranul Alam
    Department of Biomedical Engineering, Indiana University Purdue University Indianapolis IUPUI, Indianapolis, IN 46202 5251, USA
    Genomics 94:257-62. 2009
    ....
  11. pmc Genes influencing spinal bone mineral density in inbred F344, LEW, COP, and DA rats
    Imranul Alam
    Department of Biomedical Engineering, Indiana University Purdue University Indianapolis, 46202 5251, USA
    Funct Integr Genomics 10:63-72. 2010
    ..Of these, 14 genes (Akap1, Asgr2, Esd, Fam101b, Irf1, Lcp1, Ltc4s, Mdp-1, Pdhb, Plxdc1, Rabep1, Rhot1, Slc2a4, Xpo4) were confirmed by qPCR. We identified several novel candidate genes influencing spinal vBMD in rats...
  12. ncbi request reprint Whole-genome scan for linkage to bone strength and structure in inbred Fischer 344 and Lewis rats
    Imranul Alam
    Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Bone Miner Res 20:1589-96. 2005
    ..A genome-wide genetic linkage analysis identified several chromosomal regions influencing bone strength and structure in F2 progeny of Fischer 344 x Lewis inbred rats...
  13. pmc Sex-specific genetic loci for femoral neck bone mass and strength identified in inbred COP and DA rats
    Imranul Alam
    Department of Biomedical Engineering, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Bone Miner Res 23:850-9. 2008
    ..The purpose of this study is to identify sex-independent and sex-specific quantitative trait loci (QTLs) for femoral neck density, structure, and strength in inbred Copenhagen 2331 (COP) and Dark Agouti (DA) rats...
  14. pmc Genomic expression analysis of rat chromosome 4 for skeletal traits at femoral neck
    Imranul Alam
    Department of Biomedical Engineering, Indiana University Purdue University Indianapolis, Indianapolis, Indiana 46202, USA
    Physiol Genomics 35:191-6. 2008
    ..This study provides a shortened list of genetic determinants of skeletal traits at the hip and may lead to novel approaches for prevention and treatment of hip fracture...
  15. ncbi request reprint Analysis of variation in expression of autosomal dominant osteopetrosis type 2: searching for modifier genes
    Kang Chu
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Bone 37:655-61. 2005
    ..Analysis of ADO2 in our pedigrees indicates that the penetrance is 66%, with a highly variable phenotype...
  16. pmc Replication of previous genome-wide association studies of bone mineral density in premenopausal American women
    Shoji Ichikawa
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    J Bone Miner Res 25:1821-9. 2010
    ....
  17. pmc Association of adenylate cyclase 10 (ADCY10) polymorphisms and bone mineral density in healthy adults
    Shoji Ichikawa
    Department of Medicine, Indiana University School of Medicine, 541 North Clinical Drive, Clinical Building 459, Indianapolis, IN 46202 5121, USA
    Calcif Tissue Int 84:97-102. 2009
    ..However, adjacent SNPs did not corroborate the association in either men or women. In conclusion, we found a modest association between an ADCY10 polymorphism and the spinal areal BMD in premenopausal white women...
  18. pmc CLCN7 polymorphisms and bone mineral density in healthy premenopausal white women and in white men
    Kang Chu
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Bone 43:995-8. 2008
    ..However, there is no study to date that has examined whether CLCN7 polymorphisms underlie normal variation of peak BMD in healthy premenopausal white women and in white men...
  19. pmc Heterogeneous stock rat: a unique animal model for mapping genes influencing bone fragility
    Imranul Alam
    Indiana University School of Medicine, Indiana University Indianapolis, IN, USA
    Bone 48:1169-77. 2011
    ....
  20. pmc Genome screen in familial intracranial aneurysm
    Tatiana Foroud
    Indiana University School of Medicine, Indianapolis, IN, USA
    BMC Med Genet 10:3. 2009
    ..Individuals with 1st degree relatives harboring an intracranial aneurysm (IA) are at an increased risk of IA, suggesting genetic variation is an important risk factor...
  21. pmc Polymorphisms in the estrogen receptor beta (ESR2) gene are associated with bone mineral density in Caucasian men and women
    Shoji Ichikawa
    Department of Medicine, Indiana University School of Medicine, 541 North Clinical Drive, Clinical Building 459, Indianapolis, Indiana 46202 5121, USA
    J Clin Endocrinol Metab 90:5921-7. 2005
    ..Recently, we identified significant linkage for hip BMD in premenopausal sister pairs at chromosome 14q (LOD score = 3.5), where the estrogen receptor beta gene (ESR2) is located...
  22. pmc Identification of a linkage disequilibrium block in chromosome 1q associated with BMD in premenopausal white women
    Shoji Ichikawa
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202 5121, USA
    J Bone Miner Res 23:1680-8. 2008
    ....
  23. pmc Bone mineral density variation in men is influenced by sex-specific and non sex-specific quantitative trait loci
    Munro Peacock
    Department of Medicine, Indiana University School of Medicine, USA
    Bone 45:443-8. 2009
    ..The aim of this study was to perform a genome wide scan in healthy men to identify quantitative trait loci (QTL) that were significantly linked to aBMD and to test whether any of these might be sex-specific...
  24. pmc Confirmation of linkage to chromosome 1q for peak vertebral bone mineral density in premenopausal white women
    Michael J Econs
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, USA
    Am J Hum Genet 74:223-8. 2004
    ..Studies are now ongoing to identify the gene(s) contributing to peak spine BMD in women...
  25. pmc Genome-wide association study of intracranial aneurysms confirms role of Anril and SOX17 in disease risk
    Tatiana Foroud
    Indiana University School of Medicine, 410 W 10 Street, Indianapolis, IN 46202, USA
    Stroke 43:2846-52. 2012
    ..We sought to confirm previously reported loci, to identify novel risk factors, and to evaluate the contribution of these factors to familial and sporadic IA...
  26. ncbi request reprint Peak bone mineral density at the hip is linked to chromosomes 14q and 15q
    Munro Peacock
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Osteoporos Int 15:489-96. 2004
    ..Principal component had comparable LOD scores with those of the component phenotypes suggesting pleiotropic effects of these genes on hip phenotypes...
  27. ncbi request reprint Sex-specific and non-sex-specific quantitative trait loci contribute to normal variation in bone mineral density in men
    Munro Peacock
    Department of Medicine, Indiana University School of Medicine, University Hospital and Out Patient Center, 550 North University Boulevard, Room 5595, Indianapolis, Indiana 46202 5250, USA
    J Clin Endocrinol Metab 90:3060-6. 2005
    ..There are few comparable data in men. This study in men aimed to establish the heritability of peak BMD, identify QTL contributing to normal variation in BMD, and determine which QTL might be sex specific...
  28. ncbi request reprint Human ALOX12, but not ALOX15, is associated with BMD in white men and women
    Shoji Ichikawa
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202 5121, USA
    J Bone Miner Res 21:556-64. 2006
    ..Polymorphisms in human ALOX12, but not ALOX15, were significantly associated with spine BMD in white men and women, suggesting that ALOX12 may contribute to normal variation in BMD...
  29. ncbi request reprint Genetic effects for femoral biomechanics, structure, and density in C57BL/6J and C3H/HeJ inbred mouse strains
    Daniel L Koller
    Department of Medical and Molecular Genetics, Indiana University, Purdue University Indianapolis, Indianapolis, Indiana, USA
    J Bone Miner Res 18:1758-65. 2003
    ..Highly significant QTLs were detected with pleiotropic effects on many of these phenotypes, and QTLs with unique effects on specific phenotypes were found as well...
  30. pmc Sex-specific quantitative trait loci contribute to normal variation in bone structure at the proximal femur in men
    Munro Peacock
    Department of Medicine, Indiana University School of Medicine, University Hospital and Out Patient Center, 550 N University Boulevard, Room 5595, Indianapolis, IN 46202 5250, USA
    Bone 37:467-73. 2005
    ..The occurrence of sex-specific genes in humans for bone structure has important implications for the pathogenesis and treatment of osteoporosis...
  31. ncbi request reprint Heritability of changes in bone size and bone mass with age in premenopausal white sisters
    Siu L Hui
    Department of Medicine, Indiana University School of Medicine, Indianapolis, USA
    J Bone Miner Res 21:1121-5. 2006
    ..Femoral neck area expands and BMD decreases in premenopausal women. We used longitudinal DXA measurements on 388 premenopausal white sisters to show significant heritability of the rates of change in femoral neck area, BMC, and BMD...
  32. pmc SIBLING family genes and bone mineral density: association and allele-specific expression in humans
    Imranul Alam
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA Electronic address
    Bone 64:166-72. 2014
    ..Further studies are necessary to identify the functional variants and to determine the mechanisms underlying the differences in ASE and how these differences relate to the pathophysiology of osteoporosis. ..
  33. ncbi request reprint Familial intracranial aneurysms: is anatomic vulnerability heritable?
    Jason Mackey
    IU Health Neuroscience Center, 355 W 16th St, Suite 3200, Indianapolis, IN 46202, USA
    Stroke 44:38-42. 2013
    ..IA location is important because of its association with rupture. We tested the hypothesis that anatomic susceptibility to IA location exists using a family-based IA study...
  34. ncbi request reprint Sibling pair linkage and association studies between peak bone mineral density and the gene locus for the osteoclast-specific subunit (OC116) of the vacuolar proton pump on chromosome 11p12-13
    Gwenaelle Carn
    Departments of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Clin Endocrinol Metab 87:3819-24. 2002
    ..Therefore, our linkage data suggest that the chromosomal region that contains OC116 harbors a gene that affects peak BMD, but our association results indicate that polymorphisms in the OC116 gene do not affect peak BMD...
  35. pmc Allelic-based gene-gene interaction associated with quantitative traits
    JeeSun Jung
    Department of Medical and Molecular Genetics, Indiana University, School of Medicine, Indianapolis, Indiana, USA
    Genet Epidemiol 33:332-43. 2009
    ....
  36. pmc Genome screen to detect linkage to intracranial aneurysm susceptibility genes: the Familial Intracranial Aneurysm (FIA) study
    Tatiana Foroud
    Indiana University School of Medicine, Health Information and Translational Sciences Building HS 4000, 410 West 10th Street, Indianapolis, IN 46202 3002, USA
    Stroke 39:1434-40. 2008
    ..Evidence supports a substantial genetic contribution to the risk of intracranial aneurysm (IA). The purpose of this study was to identify chromosomal regions likely to harbor genes that contribute to the risk of IA...
  37. ncbi request reprint Identification of pathways for bipolar disorder: a meta-analysis
    John I Nurnberger
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis2Institute of Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, Indianapolis
    JAMA Psychiatry 71:657-64. 2014
    ..Genome-wide investigations provide systematic information regarding the neurobiology of psychiatric disorders...
  38. pmc High-resolution genome screen for bone mineral density in heterogeneous stock rat
    Imranul Alam
    Department of Medicine, Indiana University School of Medicine, IN, USA
    J Bone Miner Res 29:1619-26. 2014
    ....
  39. pmc regSNPs: a strategy for prioritizing regulatory single nucleotide substitutions
    Mingxiang Teng
    School of Computer Science and Technology, Harbin Institute of Technology, Harbin 150001, China
    Bioinformatics 28:1879-86. 2012
    ..Despite the technical advances, informatics methodologies need to be developed to prioritize thousands of variants for potential causative effects...
  40. pmc Genome-wide association study of alcohol dependence implicates a region on chromosome 11
    Howard J Edenberg
    Department of Biochemistry, Indiana University School of Medicine, Indianapolis, 46202 5122, USA
    Alcohol Clin Exp Res 34:840-52. 2010
    ..Alcohol dependence is a complex disease, and although linkage and candidate gene studies have identified several genes associated with the risk for alcoholism, these explain only a portion of the risk...
  41. ncbi request reprint Chloride channel 7 (ClCN7) gene mutations and autosomal dominant osteopetrosis, type II
    Steven G Waguespack
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    J Bone Miner Res 18:1513-8. 2003
    ..In 11 of 12 kindreds, five different missense mutations were identified in the ClCN7 gene, indicating the genetic basis and possible dominant negative mechanism for ADO2...
  42. ncbi request reprint Association of GABA(A) receptors and alcohol dependence and the effects of genetic imprinting
    Jiuzhou Song
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, Indiana 46202 5122, USA
    Am J Med Genet B Neuropsychiatr Genet 117:39-45. 2003
    ..Maternal transmissions provided no evidence for association. These data are consistent with an association between the expressed alleles in the GABA(A)-gene cluster on chromosome 15 and alcoholism that is modulated by genetic imprinting...
  43. ncbi request reprint The role of mutant UDP-N-acetyl-alpha-D-galactosamine-polypeptide N-acetylgalactosaminyltransferase 3 in regulating serum intact fibroblast growth factor 23 and matrix extracellular phosphoglycoprotein in heritable tumoral calcinosis
    Holly J Garringer
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, 975 West Walnut Street, IB130, Indianapolis, IN 46202, USA
    J Clin Endocrinol Metab 91:4037-42. 2006
    ..Recessive loss-of-function mutations in UDP-N-acetyl-alpha-D-galactosamine-polypeptide N-acetylgalactosaminyltransferase 3 (GALNT3) and fibroblast growth factor-23 (FGF23) result in TC...