Research Topics
| A L KochSummaryAffiliation: Indiana University Country: USA Publications
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Publications
What size should a bacterium be? A question of scaleA L Koch
Department of Biology, Indiana University, Bloomington 47405 6801, USA
Annu Rev Microbiol 50:317-48. 1996..To explore the limitation imposed by diffusion, analysis is developed of diffusion processes through stirred and unstirred media, diffusion through media that contains obstacles, and the effect of size and shape...
Were Gram-positive rods the first bacteria?Arthur L Koch
Biology Department, Indiana University, Jordan Hall 142, 1001 East Third Street, Bloomington, IN 47405 6801, USA
Trends Microbiol 11:166-70. 2003..So what were the properties of this cell's wall? Was it Gram-positive or Gram-negative? And was it a coccus or a rod?..
Bacterial wall as target for attack: past, present, and future researchArthur L Koch
Biology Department, Indiana University, Bloomington, Indiana 47405 6801, USA
Clin Microbiol Rev 16:673-87. 2003..It also outlines the scientific advances in our understanding of this broad area of biology...
Cell wall-deficient (CWD) bacterial pathogens: could amylotrophic lateral sclerosis (ALS) be due to one?Arthur L Koch
Biology Department, Indiana University, Bloomington, IN 47405 6801, USA
Crit Rev Microbiol 29:215-21. 2003..Here, the possibility is explored that amylotrophic lateral sclerosis (ALS) is caused by a cell wall-deficient microorganism...
Catastrophe and what to do about it if you are a bacterium: the importance of frameshift mutantsArthur L Koch
Biology Department, Indiana University, Bloomington, Indiana 47405 6801, USA
Crit Rev Microbiol 30:1-6. 2004..The mutation in likely the result of a frameshift mutation that caused the response and later another frameshift occurs to return the genome to its original state...
Bacterial choices for the consumption of multiple resources for current and future needsA L Koch
Department of Biology, Indiana University, Bloomington, IN 47405 6801, USA
Microb Ecol 49:183-97. 2005..The model can be modified for various alternate models to study the possible control of cellular uptake and metabolism for the range of ecological roles of the bacterium...
Shapes that Escherichia coli cells can achieve, as a paradigm for other bacteriaArthur L Koch
Biology Department, Indiana University, Bloomington, Indiana 47405 6801, USA
Crit Rev Microbiol 31:183-90. 2005..Some proposals are presented to understand the form and function of rods, cocci, fusiform organisms, as well as other bacteria of other shapes using the molecular biology and physiology now known for E. coli...
Future chemotherapy, with emphasis on bacterial mureinArthur L Koch
Biology Department, Indiana University, Bloomington, IN 47405-6801, USA
FEMS Immunol Med Microbiol 46:158-65. 2006
Partition of old murein in small patches over the entire wall of E. coli cells forced to grow as a coccoidArthur L Koch
Biology Department, Indiana University, 1001 East Third Street, Bloomington, Indiana, 47405 6801, USA
Curr Microbiol 52:249-53. 2006..The work in the De Pedro et al. paper from 2001 was done with cells of same strain as in the earlier papers with rod-shaped cells, so the results of computer analysis of the fluorescence micrographs can be critically compared...
Unidirectional movement of flares of cells of Myxococcus xanthusArthur L Koch
Biology Department, Indiana University, Bloomington, Indiana 47405, USA
Crit Rev Microbiol 32:87-90. 2006..This proposed type of mutation back mutates to wild type and the column no longer functions as such and only wild-type cells are present...
The exocytoskeletonArthur L Koch
Biology Department, Indiana University, Bloomington, IN 47405, USA
J Mol Microbiol Biotechnol 11:115-25. 2006....
Evolution of temperate pathogens: the bacteriophage/bacteria paradigmArthur L Koch
Biology Department, Indiana University, Bloomington, IN 47405 6801, USA
Virol J 4:121. 2007....
Why are rod-shaped bacteria rod shaped?Arthur L Koch
Biology Dept, Indiana University, Bloomington, IN 47405 6801, USA
Trends Microbiol 10:452-5. 2002..Here, I discuss two hypothetical mechanisms, one for Gram-positive rods and the other for Gram-negative rods. These mechanisms are consistent with what is known, but make some unproven assumptions...
Control of the bacterial cell cycle by cytoplasmic growthArthur L Koch
Biology Department, Indiana University, Bloomington 47405 6801, USA
Crit Rev Microbiol 28:61-77. 2002....
Can synchronous cultures of bacteria be manufactured?A L Koch
Biology Department, Indiana University, Bloomington 47405 6801, USA
Crit Rev Microbiol 27:223-37. 2001..These cultures would useful in studying other aspect of the physiology of cell growth...
Microbial physiology and ecology of slow growthA L Koch
Biology Department, Indiana University, Bloomington 47405, USA
Microbiol Mol Biol Rev 61:305-18. 1997..The relationship between uptake and growth is considered. Finally, too little substrate may lead to catastrophic attempts at mounting molecular syntheses that cannot be completed...
The three-for-one model for gram-negative wall growth: a problem and a possible solutionA L Koch
Biology Department, Indiana University, Bloomington 47405, USA
FEMS Microbiol Lett 162:127-34. 1998....
The strategy of Myxococcus xanthus for group cooperative behaviorA L Koch
Biology Department, Indiana University, Bloomington 47405 6801, USA
Antonie Van Leeuwenhoek 73:299-313. 1998..xanthus. Some tests for this model are suggested...
Diffusion through agar blocks of finite dimensions: a theoretical analysis of three systems of practical significance in microbiologyA L Koch
Biology Department, Indiana University, Bloomington 47405 6801, USA
Microbiology 145:643-54. 1999....
Attachment of the chromosome to the cell poles: the strategy for the growth of bacteria in two and three dimensionsA L Koch
Department of Biology, Indiana University, Bloomington, IN, 47405 6801, USA
J Theor Biol 199:213-21. 1999..A further possible extension to three dimensions to generate octets of cells is proposed...
The re-incarnation, re-interpretation and re-demise of the transition probability modelA L Koch
Biology Department, Indiana University, Bloomington 47405 6801, USA
J Biotechnol 71:143-56. 1999..The subpopulations, however, distort the population distribution in such a way as to fit better the exponential tails of the alpha and beta curves of the TP model...
The exoskeleton of bacterial cells (the sacculus): still a highly attractive target for antibacterial agents that will last for a long timeA L Koch
Biology Department, Indiana University, Bloomington 47405 6801, USA
Crit Rev Microbiol 26:1-35. 2000....
Penicillin binding proteins, beta-lactams, and lactamases: offensives, attacks, and defensive countermeasuresA L Koch
Biology Department, Indiana University, Bloomington 47405 6801, USA
Crit Rev Microbiol 26:205-20. 2000..In the last 60 years the resistant bacteria in the main arose by movement of genes from other organisms, from minor genetic changes, and from alteration of the regulation of synthesis...
Simulation of the conformation of the murein fabric: the oligoglycan, penta-muropeptide, and cross-linked nona-muropeptideA L Koch
Department of Biology, Indiana University, Bloomington 47405 6801, USA
Arch Microbiol 174:429-39. 2000..This suggests a new model for growth of the bacterial cell wall that depends on changes in the chemical conformation of the cross-bridge structure as it comes to bear stress...
Oligotrophs versus copiotrophsA L Koch
Biology Department, Indiana University, Jordan Hall 142, 1001 E Third St, Bloomington, IN 47405 6801, USA
Bioessays 23:657-61. 2001..This essay asks why do the oligotrophs not occupy richer environments, and why are copiotrophs not more prevalent in chronic starvation environments?..
Stone age diseases and modern AIDSArthur L Koch
Biology Department, Indiana University, Bloomington, IN 47405 6801, USA
Virol J 5:93. 2008..For the pathogens of a diploid there is a particularly effective strategy, that of being sexually transmitted. Then the hosts' themselves transfer the pathogen...
Length distribution of the peptidoglycan chains in the sacculus of Escherichia coliA L Koch
Department of Biology, Indiana University, Bloomington, IN, 47405 6801, USA
J Theor Biol 204:533-41. 2000....
The first cellArthur L Koch
Biology Department, Indiana University, Bloomington, IN 47405-6801, USA
Adv Microb Physiol 50:227-59. 2005..This long process, subject to strong evolutionary selection, developed the cellular biology that is now shared by all extant organisms...
Patchiness of murein insertion into the sidewall of Escherichia coliMiguel A de Pedro
Centro de Biologia Molecular 'Severo Ochoa, , Facultad de Ciencias, 28049 Madrid, Spain
Microbiology 149:1753-61. 2003....
