J E Klaunig

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. ncbi request reprint Mode of action of butoxyethanol-induced mouse liver hemangiosarcomas and hepatocellular carcinomas
    J E Klaunig
    Indiana School of Medicine, 635 Barnhill Drive, MS 547, Indianapolis, IN 46202, USA
    Toxicol Lett 156:107-15. 2005
  2. pmc The role of oxidative stress in chemical carcinogenesis
    J E Klaunig
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis 46202, USA
    Environ Health Perspect 106:289-95. 1998
  3. ncbi request reprint Mechanisms of cancer chemoprevention in hepatic carcinogenesis: modulation of focal lesion growth in mice
    J E Klaunig
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis 46202, USA
    Toxicol Sci 52:101-6. 1999
  4. ncbi request reprint Reversibility and persistence of di-2-ethylhexyl phthalate (DEHP)- and phenobarbital-induced hepatocellular changes in rodents
    J S Isenberg
    Division of Toxicology, Department of Pharmacology and Toxicology, Indiana University School of Medicine, 635 Barnhill Drive, MS-1021, Indianapolis, IN 46202, USA
    Toxicol Sci 64:192-9. 2001
  5. ncbi request reprint The role of oxidative stress in indium phosphide-induced lung carcinogenesis in rats
    B C Gottschling
    Indiana University School of Medicine, Division of Toxicology, Department of Pharmacology and Toxicology, 635 Barnhill Drive, MS 1021, Indianapolis, Indiana 46202, USA
    Toxicol Sci 64:28-40. 2001
  6. ncbi request reprint Comparative effects of dieldrin on hepatic ploidy, cell proliferation, and apoptosis in rodent liver
    L M Kamendulis
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis 46202, USA
    J Toxicol Environ Health A 62:127-41. 2001
  7. ncbi request reprint Cancer dose--response assessment for acrylonitrile based upon rodent brain tumor incidence: use of epidemiologic, mechanistic, and pharmacokinetic support for nonlinearity
    C R Kirman
    The Sapphire Group, Inc, Beachwood, OH, USA
    Regul Toxicol Pharmacol 43:85-103. 2005

Collaborators

Detail Information

Publications7

  1. ncbi request reprint Mode of action of butoxyethanol-induced mouse liver hemangiosarcomas and hepatocellular carcinomas
    J E Klaunig
    Indiana School of Medicine, 635 Barnhill Drive, MS 547, Indianapolis, IN 46202, USA
    Toxicol Lett 156:107-15. 2005
    ....
  2. pmc The role of oxidative stress in chemical carcinogenesis
    J E Klaunig
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis 46202, USA
    Environ Health Perspect 106:289-95. 1998
    ..These results and findings reported by others support a potential role for oxidative-induced injury in the cancer process specifically during the promotion stage...
  3. ncbi request reprint Mechanisms of cancer chemoprevention in hepatic carcinogenesis: modulation of focal lesion growth in mice
    J E Klaunig
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis 46202, USA
    Toxicol Sci 52:101-6. 1999
    ..Antioxidant dietary supplementation or caloric restriction prevented the lesion growth. This appeared to be through an increase in apoptosis in the hepatic lesions...
  4. ncbi request reprint Reversibility and persistence of di-2-ethylhexyl phthalate (DEHP)- and phenobarbital-induced hepatocellular changes in rodents
    J S Isenberg
    Division of Toxicology, Department of Pharmacology and Toxicology, Indiana University School of Medicine, 635 Barnhill Drive, MS-1021, Indianapolis, IN 46202, USA
    Toxicol Sci 64:192-9. 2001
    ..Studies with phenobarbital produced a similar pattern of response...
  5. ncbi request reprint The role of oxidative stress in indium phosphide-induced lung carcinogenesis in rats
    B C Gottschling
    Indiana University School of Medicine, Division of Toxicology, Department of Pharmacology and Toxicology, 635 Barnhill Drive, MS 1021, Indianapolis, Indiana 46202, USA
    Toxicol Sci 64:28-40. 2001
    ..These findings suggest that IP inhalation causes pulmonary inflammation associated with oxidative stress, resulting in progression to atypical hyperplasia and neoplasia...
  6. ncbi request reprint Comparative effects of dieldrin on hepatic ploidy, cell proliferation, and apoptosis in rodent liver
    L M Kamendulis
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis 46202, USA
    J Toxicol Environ Health A 62:127-41. 2001
    ..It is proposed that the observed increase in nuclear ploidy in the mouse may reflect an adaptive response to dieldrin exposure...
  7. ncbi request reprint Cancer dose--response assessment for acrylonitrile based upon rodent brain tumor incidence: use of epidemiologic, mechanistic, and pharmacokinetic support for nonlinearity
    C R Kirman
    The Sapphire Group, Inc, Beachwood, OH, USA
    Regul Toxicol Pharmacol 43:85-103. 2005
    ..Accordingly, oral doses below 0.009 mg/kg-day and air concentrations below 0.1mg/m(3) are not expected to pose an appreciable risk to human populations exposed to AN...