David Kareken

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. pmc Family history of alcoholism interacts with alcohol to affect brain regions involved in behavioral inhibition
    David A Kareken
    Neuropsychology Section GH 4700, Department of Neurology, Indiana University School of Medicine, 355 W 16th Street, Indianapolis, IN 46202, USA
    Psychopharmacology (Berl) 228:335-45. 2013
  2. pmc fMRI of the brain's response to stimuli experimentally paired with alcohol intoxication
    David A Kareken
    Department of Neurology, Indiana University School of Medicine, 541 Clinical Drive CL 285, Indianapolis, IN 46202, USA
    Psychopharmacology (Berl) 220:787-97. 2012
  3. doi request reprint A polymorphism in GABRA2 is associated with the medial frontal response to alcohol cues in an fMRI study
    David A Kareken
    Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Alcohol Clin Exp Res 34:2169-78. 2010
  4. pmc Family history of alcoholism mediates the frontal response to alcoholic drink odors and alcohol in at-risk drinkers
    David A Kareken
    Department of Neurology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Neuroimage 50:267-76. 2010
  5. ncbi request reprint Word rhyming as a probe of hemispheric language dominance with functional magnetic resonance imaging
    D A Kareken
    Department of Neurology, Indiana University School of Medicine, Indianapolis 46202, USA
    Neuropsychiatry Neuropsychol Behav Neurol 13:264-70. 2000
  6. ncbi request reprint Olfactory system activation from sniffing: effects in piriform and orbitofrontal cortex
    David A Kareken
    Department of Neurology, Neuropsychology Section RI 1773, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Neuroimage 22:456-65. 2004
  7. ncbi request reprint Alcohol-related olfactory cues activate the nucleus accumbens and ventral tegmental area in high-risk drinkers: preliminary findings
    David A Kareken
    Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Alcohol Clin Exp Res 28:550-7. 2004
  8. ncbi request reprint Functional anatomy of human odor sensation, discrimination, and identification in health and aging
    David A Kareken
    Department of Neurology, Indiana University School of Medicine, Indianapolis 46202, USA
    Neuropsychology 17:482-95. 2003
  9. ncbi request reprint Olfactory-evoked regional cerebral blood flow in Alzheimer's disease
    D A Kareken
    Department of Neurology, Indiana University School of Medicine, Indianapolis 46202, USA
    Neuropsychology 15:18-29. 2001
  10. ncbi request reprint Recent drinking history: association with family history of alcoholism and the acute response to alcohol during a 60 mg% clamp
    Vijay A Ramchandani
    Department of Medicine, Indiana University School of Medicine and The Roudeboush Veterans Affairs Medical Center, Indianapolis, Indiana 46202, USA
    J Stud Alcohol 63:734-44. 2002

Research Grants

  1. fMRI of the Mesolimbic Dopamine System in Risky Drinkers
    David Kareken; Fiscal Year: 2007
  2. Dopaminergic Function in Alcoholism
    David A Kareken; Fiscal Year: 2010
  3. Dopaminergic Function in Alcoholism
    David Kareken; Fiscal Year: 2009

Collaborators

Detail Information

Publications24

  1. pmc Family history of alcoholism interacts with alcohol to affect brain regions involved in behavioral inhibition
    David A Kareken
    Neuropsychology Section GH 4700, Department of Neurology, Indiana University School of Medicine, 355 W 16th Street, Indianapolis, IN 46202, USA
    Psychopharmacology (Berl) 228:335-45. 2013
    ..One operational definition of impulsive behavior is the stop-signal task (SST) which measures the time needed to stop a ballistic hand movement...
  2. pmc fMRI of the brain's response to stimuli experimentally paired with alcohol intoxication
    David A Kareken
    Department of Neurology, Indiana University School of Medicine, 541 Clinical Drive CL 285, Indianapolis, IN 46202, USA
    Psychopharmacology (Berl) 220:787-97. 2012
    ..Individuals learn associations between alcohol's sensory properties and intoxication, with such conditioned stimuli (CS) becoming involved in craving and relapse. However, these CS also carry idiosyncratic associations...
  3. doi request reprint A polymorphism in GABRA2 is associated with the medial frontal response to alcohol cues in an fMRI study
    David A Kareken
    Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Alcohol Clin Exp Res 34:2169-78. 2010
    ..In this study, we stratified subjects who had participated in an fMRI study of alcohol cue responses according to their genotype at a SNP in GABRA2 (rs279871) shown to be associated with alcohol dependence (Edenberg et al., 2004)...
  4. pmc Family history of alcoholism mediates the frontal response to alcoholic drink odors and alcohol in at-risk drinkers
    David A Kareken
    Department of Neurology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Neuroimage 50:267-76. 2010
    ..This suggests that a family history of alcoholism and brain exposure to alcohol interact in heavy drinkers to differentially affect how the brain responds to alcohol cues...
  5. ncbi request reprint Word rhyming as a probe of hemispheric language dominance with functional magnetic resonance imaging
    D A Kareken
    Department of Neurology, Indiana University School of Medicine, Indianapolis 46202, USA
    Neuropsychiatry Neuropsychol Behav Neurol 13:264-70. 2000
    ..The goal of this study was to create a probe of hemispheric dominance for language using functional magnetic resonance imaging...
  6. ncbi request reprint Olfactory system activation from sniffing: effects in piriform and orbitofrontal cortex
    David A Kareken
    Department of Neurology, Neuropsychology Section RI 1773, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Neuroimage 22:456-65. 2004
    ..A right orbitofrontal region was also activated with odorless sniffing, which suggests a possible orbitofrontal role in guided olfactory exploration...
  7. ncbi request reprint Alcohol-related olfactory cues activate the nucleus accumbens and ventral tegmental area in high-risk drinkers: preliminary findings
    David A Kareken
    Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Alcohol Clin Exp Res 28:550-7. 2004
    ..The mesocorticolimbic dopamine system is implicated in motivation and reward and may be involved in the development of alcoholism...
  8. ncbi request reprint Functional anatomy of human odor sensation, discrimination, and identification in health and aging
    David A Kareken
    Department of Neurology, Indiana University School of Medicine, Indianapolis 46202, USA
    Neuropsychology 17:482-95. 2003
    ..Adjusting for detection threshold eliminated GR/MOG group differences during sensory stimulation. Diminished threshold may lead to reduced engagement of olfactory association areas...
  9. ncbi request reprint Olfactory-evoked regional cerebral blood flow in Alzheimer's disease
    D A Kareken
    Department of Neurology, Indiana University School of Medicine, Indianapolis 46202, USA
    Neuropsychology 15:18-29. 2001
    ..Given olfactory bulb projections to the mesial temporal lobe, olfactory stimulation during functional imaging might detect early dysfunction in this region...
  10. ncbi request reprint Recent drinking history: association with family history of alcoholism and the acute response to alcohol during a 60 mg% clamp
    Vijay A Ramchandani
    Department of Medicine, Indiana University School of Medicine and The Roudeboush Veterans Affairs Medical Center, Indianapolis, Indiana 46202, USA
    J Stud Alcohol 63:734-44. 2002
    ....
  11. pmc Alcohol sensitizes cerebral responses to the odors of alcoholic drinks: an fMRI study
    Veronique Bragulat
    Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Alcohol Clin Exp Res 32:1124-34. 2008
    ..Here we hypothesized that priming exposure to alcohol would enhance responses to AO in the NAc and orbitofrontal cortex in comparison to NApO (grass, leather) and to the appetitive control odors (ApCO) of chocolate and grape...
  12. pmc Abnormal error-related antisaccade activation in premanifest and early manifest Huntington disease
    Jason Rupp
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202 5251, USA
    Neuropsychology 25:306-18. 2011
    ..This study aimed to identify the neural substrates underlying altered antisaccadic performance...
  13. ncbi request reprint Involvement of the left anterior insula and frontopolar gyrus in odor discrimination
    Jane Plailly
    Neuropsychology Section, Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Hum Brain Mapp 28:363-72. 2007
    ..The left anterior insula is likely involved in the evaluation of odor properties. Consistent with other studies, frontopolar and middle frontal gyrus activation is more likely related to working memory during odor discrimination...
  14. pmc When what you see isn't what you get: alcohol cues, alcohol administration, prediction error, and human striatal dopamine
    Karmen K Yoder
    Department of Radiology, Indiana University School of Medicine, Indianapolis, IN, USA
    Alcohol Clin Exp Res 33:139-49. 2009
    ..This study assessed the distinct effects of alcohol-related cues and alcohol administration on striatal DA release in healthy humans...
  15. ncbi request reprint Dopamine D(2) receptor availability is associated with subjective responses to alcohol
    Karmen K Yoder
    Department of Radiology, Division of Research, Section of Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN 46206, USA
    Alcohol Clin Exp Res 29:965-70. 2005
    ..Here, we examined the relationship between dopamine D2 receptors in the nucleus accumbens and scores of perceived "high" and "intoxication" during an intravenous (IV) alcohol infusion...
  16. pmc What were they thinking? Cognitive states may influence [11C]raclopride binding potential in the striatum
    Karmen K Yoder
    Department of Radiology, Indiana University School of Medicine, Indianapolis, IN, United States
    Neurosci Lett 430:38-42. 2008
    ..Our findings suggest that even slight differences in cognitive states between groups can have an effect on BP(ND), presumably mediated by changes in endogenous dopamine concentration...
  17. ncbi request reprint Heterogeneous effects of alcohol on dopamine release in the striatum: a PET study
    Karmen K Yoder
    Department of Radiology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Alcohol Clin Exp Res 31:965-73. 2007
    ..Our approach was to identify voxels that exhibited alcohol-induced DA responses within the striatum, and to determine the relationships between DA responses and alcohol-related behavior...
  18. ncbi request reprint Saccadic eye movements are associated with a family history of alcoholism at baseline and after exposure to alcohol
    Tanya Blekher
    Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana 46202 5175, USA
    Alcohol Clin Exp Res 26:1568-73. 2002
    ..To evaluate the influence of family history of alcoholism (FHA) on the response of saccadic eye movements to alcohol...
  19. ncbi request reprint Neural correlates of olfactory change detection
    Merav Sabri
    Department of Neurology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Neuroimage 25:969-74. 2005
    ..05, corrected). Subgenual cingulate and posterior orbital cortex may therefore play a role in detecting discrepant olfactory events while attention is otherwise engaged in another sensory modality...
  20. ncbi request reprint Neural correlates of auditory sensory memory and automatic change detection
    Merav Sabri
    Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA
    Neuroimage 21:69-74. 2004
    ..These results support the hypothesis that the automatic detection of auditory change occurs in the STG bilaterally and relies on the maintenance of sensory memory traces...
  21. ncbi request reprint Neuropsychological test performance in healthy volunteers before and after donepezil administration
    Leigh J Beglinger
    Department of Neurology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Psychopharmacol 18:102-8. 2004
    ..While the results are counter to expectations, some tests in the battery did detect a cognitive change (transient mild worsening during drug administration) in healthy volunteers...
  22. ncbi request reprint Involvement of right piriform cortex in olfactory familiarity judgments
    Jane Plailly
    Neurosciences et Systemes Sensoriels, Universite Claude Bernard Lyon 1, UMR CNRS 5020, IFR 19, Institut Federatif des Neurosciences de Lyon, 50 avenue Tony Garnier, 69366 Lyon Cedex 07, France
    Neuroimage 24:1032-41. 2005
    ..Further analyses demonstrated that the right PC was more strongly activated than the left PC. This result supports the notion that the right PC is preferentially involved in judgments of odor familiarity...
  23. ncbi request reprint fMRI of emotional responses to odors: influence of hedonic valence and judgment, handedness, and gender
    Jean P Royet
    Neurosciences and Sensory Systems, CNRS UMR 5020, Claude Bernard University Lyon1, 69007, Lyon, France
    Neuroimage 20:713-28. 2003
    ..Finally, left orbitofrontal cortex was more active in women than men, potentially in relation to women's well-documented advantage in odor identification...
  24. ncbi request reprint Neuropsychological test performance in healthy elderly volunteers before and after donepezil administration: a randomized, controlled study
    Leigh J Beglinger
    Department of Psychiatry, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    J Clin Psychopharmacol 25:159-65. 2005
    ....

Research Grants8

  1. fMRI of the Mesolimbic Dopamine System in Risky Drinkers
    David Kareken; Fiscal Year: 2007
    ..The work will advance our understanding of how brain function in key regions is associated with one or both of two main risk factors for alcoholism. ..
  2. Dopaminergic Function in Alcoholism
    David A Kareken; Fiscal Year: 2010
    ..Research such as this has the potential to show exactly how dopamine neurotransmission is altered in alcoholism, findings that may lead to better treatments and diagnosis. ..
  3. Dopaminergic Function in Alcoholism
    David Kareken; Fiscal Year: 2009
    ..A better understanding of these phenomena may lead to better diagnosis and treatment. ..