Research Topics
Species | David KarekenSummaryAffiliation: Indiana University Country: USA Publications
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Publications
fMRI of the brain's response to stimuli experimentally paired with alcohol intoxicationDavid A Kareken
Department of Neurology, Indiana University School of Medicine, 541 Clinical Drive CL 285, Indianapolis, IN 46202, USA
Psychopharmacology (Berl) 220:787-97. 2012..Individuals learn associations between alcohol's sensory properties and intoxication, with such conditioned stimuli (CS) becoming involved in craving and relapse. However, these CS also carry idiosyncratic associations...
A polymorphism in GABRA2 is associated with the medial frontal response to alcohol cues in an fMRI studyDavid A Kareken
Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Alcohol Clin Exp Res 34:2169-78. 2010..In this study, we stratified subjects who had participated in an fMRI study of alcohol cue responses according to their genotype at a SNP in GABRA2 (rs279871) shown to be associated with alcohol dependence (Edenberg et al., 2004)...- Family history of alcoholism mediates the frontal response to alcoholic drink odors and alcohol in at-risk drinkersDavid A Kareken
Department of Neurology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Neuroimage 50:267-76. 2010..This suggests that a family history of alcoholism and brain exposure to alcohol interact in heavy drinkers to differentially affect how the brain responds to alcohol cues... 
Word rhyming as a probe of hemispheric language dominance with functional magnetic resonance imagingD A Kareken
Department of Neurology, Indiana University School of Medicine, Indianapolis 46202, USA
Neuropsychiatry Neuropsychol Behav Neurol 13:264-70. 2000..The goal of this study was to create a probe of hemispheric dominance for language using functional magnetic resonance imaging...- Olfactory system activation from sniffing: effects in piriform and orbitofrontal cortexDavid A Kareken
Department of Neurology, Neuropsychology Section RI 1773, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Neuroimage 22:456-65. 2004..A right orbitofrontal region was also activated with odorless sniffing, which suggests a possible orbitofrontal role in guided olfactory exploration... - Alcohol-related olfactory cues activate the nucleus accumbens and ventral tegmental area in high-risk drinkers: preliminary findingsDavid A Kareken
Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Alcohol Clin Exp Res 28:550-7. 2004..The mesocorticolimbic dopamine system is implicated in motivation and reward and may be involved in the development of alcoholism... - Olfactory-evoked regional cerebral blood flow in Alzheimer's diseaseD A Kareken
Department of Neurology, Indiana University School of Medicine, Indianapolis 46202, USA
Neuropsychology 15:18-29. 2001..Given olfactory bulb projections to the mesial temporal lobe, olfactory stimulation during functional imaging might detect early dysfunction in this region... - Functional anatomy of human odor sensation, discrimination, and identification in health and agingDavid A Kareken
Department of Neurology, Indiana University School of Medicine, Indianapolis 46202, USA
Neuropsychology 17:482-95. 2003..Adjusting for detection threshold eliminated GR/MOG group differences during sensory stimulation. Diminished threshold may lead to reduced engagement of olfactory association areas... - Recent drinking history: association with family history of alcoholism and the acute response to alcohol during a 60 mg% clampVijay A Ramchandani
Department of Medicine, Indiana University School of Medicine and The Roudeboush Veterans Affairs Medical Center, Indianapolis, Indiana 46202, USA
J Stud Alcohol 63:734-44. 2002..Although RDH was not associated with FHA in this study, it may be an important determinant of the response to alcohol... - Alcohol sensitizes cerebral responses to the odors of alcoholic drinks: an fMRI studyVeronique Bragulat
Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Alcohol Clin Exp Res 32:1124-34. 2008..Here we hypothesized that priming exposure to alcohol would enhance responses to AO in the NAc and orbitofrontal cortex in comparison to NApO (grass, leather) and to the appetitive control odors (ApCO) of chocolate and grape... - Abnormal error-related antisaccade activation in premanifest and early manifest Huntington diseaseJason Rupp
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202 5251, USA
Neuropsychology 25:306-18. 2011..This study aimed to identify the neural substrates underlying altered antisaccadic performance... - When what you see isn't what you get: alcohol cues, alcohol administration, prediction error, and human striatal dopamineKarmen K Yoder
Department of Radiology, Indiana University School of Medicine, Indianapolis, IN, USA
Alcohol Clin Exp Res 33:139-49. 2009..This study assessed the distinct effects of alcohol-related cues and alcohol administration on striatal DA release in healthy humans... - Involvement of the left anterior insula and frontopolar gyrus in odor discriminationJane Plailly
Neuropsychology Section, Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Hum Brain Mapp 28:363-72. 2007..The left anterior insula is likely involved in the evaluation of odor properties. Consistent with other studies, frontopolar and middle frontal gyrus activation is more likely related to working memory during odor discrimination... - Saccadic eye movements are associated with a family history of alcoholism at baseline and after exposure to alcoholTanya Blekher
Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana 46202 5175, USA
Alcohol Clin Exp Res 26:1568-73. 2002..To evaluate the influence of family history of alcoholism (FHA) on the response of saccadic eye movements to alcohol... - Dopamine D(2) receptor availability is associated with subjective responses to alcoholKarmen K Yoder
Department of Radiology, Division of Research, Section of Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN 46206, USA
Alcohol Clin Exp Res 29:965-70. 2005..Here, we examined the relationship between dopamine D2 receptors in the nucleus accumbens and scores of perceived "high" and "intoxication" during an intravenous (IV) alcohol infusion... - Heterogeneous effects of alcohol on dopamine release in the striatum: a PET studyKarmen K Yoder
Department of Radiology, Indiana University School of Medicine, Indianapolis, Indiana, USA
Alcohol Clin Exp Res 31:965-73. 2007..Our approach was to identify voxels that exhibited alcohol-induced DA responses within the striatum, and to determine the relationships between DA responses and alcohol-related behavior... - What were they thinking? Cognitive states may influence [11C]raclopride binding potential in the striatumKarmen K Yoder
Department of Radiology, Indiana University School of Medicine, Indianapolis, IN, United States
Neurosci Lett 430:38-42. 2008..Our findings suggest that even slight differences in cognitive states between groups can have an effect on BP(ND), presumably mediated by changes in endogenous dopamine concentration... - Neural correlates of olfactory change detectionMerav Sabri
Department of Neurology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Neuroimage 25:969-74. 2005..05, corrected). Subgenual cingulate and posterior orbital cortex may therefore play a role in detecting discrepant olfactory events while attention is otherwise engaged in another sensory modality... - Neural correlates of auditory sensory memory and automatic change detectionMerav Sabri
Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA
Neuroimage 21:69-74. 2004..These results support the hypothesis that the automatic detection of auditory change occurs in the STG bilaterally and relies on the maintenance of sensory memory traces... - Neuropsychological test performance in healthy volunteers before and after donepezil administrationLeigh J Beglinger
Department of Neurology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
J Psychopharmacol 18:102-8. 2004..While the results are counter to expectations, some tests in the battery did detect a cognitive change (transient mild worsening during drug administration) in healthy volunteers... - Involvement of right piriform cortex in olfactory familiarity judgmentsJane Plailly
Neurosciences et Systemes Sensoriels, Universite Claude Bernard Lyon 1, UMR CNRS 5020, IFR 19, Institut Federatif des Neurosciences de Lyon, 50 avenue Tony Garnier, 69366 Lyon Cedex 07, France
Neuroimage 24:1032-41. 2005..Further analyses demonstrated that the right PC was more strongly activated than the left PC. This result supports the notion that the right PC is preferentially involved in judgments of odor familiarity... - fMRI of emotional responses to odors: influence of hedonic valence and judgment, handedness, and genderJean P Royet
Neurosciences and Sensory Systems, CNRS UMR 5020, Claude Bernard University Lyon1, 69007, Lyon, France
Neuroimage 20:713-28. 2003..Finally, left orbitofrontal cortex was more active in women than men, potentially in relation to women's well-documented advantage in odor identification... - Neuropsychological test performance in healthy elderly volunteers before and after donepezil administration: a randomized, controlled studyLeigh J Beglinger
Department of Psychiatry, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
J Clin Psychopharmacol 25:159-65. 2005....
Research Grants
- fMRI of the Mesolimbic Dopamine System in Risky DrinkersDavid Kareken; Fiscal Year: 2007..The work will advance our understanding of how brain function in key regions is associated with one or both of two main risk factors for alcoholism. ..
- Dopaminergic Function in AlcoholismDavid A Kareken; Fiscal Year: 2010..Research such as this has the potential to show exactly how dopamine neurotransmission is altered in alcoholism, findings that may lead to better treatments and diagnosis. ..
- Dopaminergic Function in AlcoholismDavid Kareken; Fiscal Year: 2009..A better understanding of these phenomena may lead to better diagnosis and treatment. ..