R Kapur

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. pmc Targeting SHP2 phosphatase in Myeloproliferative Neoplasms
    Raghuveer Singh Mali
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis
    Oncotarget 3:1049-51. 2012
  2. pmc Targeting rho associated kinases in leukemia and myeloproliferative neoplasms
    Raghuveer Singh Mali
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis
    Oncotarget 3:909-10. 2012
  3. pmc Unique and redundant roles of class IA PI3Kinase regulatory subunits in mast cell development
    Raghuveer Singh Mali
    Department of Pediatrics Indiana University School of Medicine Indianapolis, IN USA
    Cell Cycle 12:7-8. 2013
  4. pmc Class I(A) PI3Kinase regulatory subunit, p85α, mediates mast cell development through regulation of growth and survival related genes
    Subha Krishnan
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
    PLoS ONE 7:e28979. 2012
  5. ncbi request reprint A novel mechanism of cooperation between c-Kit and erythropoietin receptor. Stem cell factor induces the expression of Stat5 and erythropoietin receptor, resulting in efficient proliferation and survival by erythropoietin
    R Kapur
    Herman B Wells Center for Pediatric Research, Department of Pediatrics, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 276:1099-106. 2001
  6. ncbi request reprint Role of p38 and ERK MAP kinase in proliferation of erythroid progenitors in response to stimulation by soluble and membrane isoforms of stem cell factor
    Reuben Kapur
    Section of Neonatal Perinatal Medicine, Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Blood 100:1287-93. 2002
  7. ncbi request reprint The presence of novel amino acids in the cytoplasmic domain of stem cell factor results in hematopoietic defects in Steel(17H) mice
    R Kapur
    The Section of Pediatric Hematology Oncology, Department of Pediatrics, James Whitcomb Riley Hospital for Children, Indiana, USA
    Blood 94:1915-25. 1999
  8. ncbi request reprint Cross-talk between alpha(4)beta(1)/alpha(5)beta(1) and c-Kit results in opposing effect on growth and survival of hematopoietic cells via the activation of focal adhesion kinase, mitogen-activated protein kinase, and Akt signaling pathways
    R Kapur
    The Section of Pediatric Hematology/Oncology, Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indianapolis, Indiana 46202, USA
    Blood 97:1975-81. 2001
  9. ncbi request reprint Rac2 stimulates Akt activation affecting BAD/Bcl-XL expression while mediating survival and actin function in primary mast cells
    F C Yang
    Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis 46202, USA
    Immunity 12:557-68. 2000
  10. pmc Loss of SIMPL compromises TNF-alpha-dependent survival of hematopoietic progenitors
    Eric A Benson
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202 5122, USA
    Exp Hematol 38:71-81. 2010

Collaborators

Detail Information

Publications51

  1. pmc Targeting SHP2 phosphatase in Myeloproliferative Neoplasms
    Raghuveer Singh Mali
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis
    Oncotarget 3:1049-51. 2012
    ..A combined understanding of Shp2's structural requirement as well as defining the appropriate cellular population(s) for targeting Shp2 is likely to aid in the design of better Shp2 inhibitors in the future...
  2. pmc Targeting rho associated kinases in leukemia and myeloproliferative neoplasms
    Raghuveer Singh Mali
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis
    Oncotarget 3:909-10. 2012
    ..If ROCKs are going to be targeted as anti-leukemic agents either as a monotherapy or in combination with existing drugs, a better characterization of the relative contribution of ROCK1 and ROCK2 in disease progression is essential...
  3. pmc Unique and redundant roles of class IA PI3Kinase regulatory subunits in mast cell development
    Raghuveer Singh Mali
    Department of Pediatrics Indiana University School of Medicine Indianapolis, IN USA
    Cell Cycle 12:7-8. 2013
    ..Comment on: Krishnan S, et al. Blood 2012; 119:3951-61...
  4. pmc Class I(A) PI3Kinase regulatory subunit, p85α, mediates mast cell development through regulation of growth and survival related genes
    Subha Krishnan
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
    PLoS ONE 7:e28979. 2012
    ..Our results suggest that p85α is involved in mast cell development through regulation of expression of growth, survival and cell cycle related genes...
  5. ncbi request reprint A novel mechanism of cooperation between c-Kit and erythropoietin receptor. Stem cell factor induces the expression of Stat5 and erythropoietin receptor, resulting in efficient proliferation and survival by erythropoietin
    R Kapur
    Herman B Wells Center for Pediatric Research, Department of Pediatrics, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 276:1099-106. 2001
    ....
  6. ncbi request reprint Role of p38 and ERK MAP kinase in proliferation of erythroid progenitors in response to stimulation by soluble and membrane isoforms of stem cell factor
    Reuben Kapur
    Section of Neonatal Perinatal Medicine, Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Blood 100:1287-93. 2002
    ..These results suggest that different isoforms of SCF may use different biochemical pathways in stimulation of survival and/or proliferation of erythroid cells...
  7. ncbi request reprint The presence of novel amino acids in the cytoplasmic domain of stem cell factor results in hematopoietic defects in Steel(17H) mice
    R Kapur
    The Section of Pediatric Hematology Oncology, Department of Pediatrics, James Whitcomb Riley Hospital for Children, Indiana, USA
    Blood 94:1915-25. 1999
    ..In vivo, transgene expression of the membrane-restricted (MR) (SCF(X9/D3)) SCF in Sl/Sl(17H) mutants results in a significant improvement in peripheral red blood cell counts in comparison to Sl/Sl(17H) mice...
  8. ncbi request reprint Cross-talk between alpha(4)beta(1)/alpha(5)beta(1) and c-Kit results in opposing effect on growth and survival of hematopoietic cells via the activation of focal adhesion kinase, mitogen-activated protein kinase, and Akt signaling pathways
    R Kapur
    The Section of Pediatric Hematology/Oncology, Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indianapolis, Indiana 46202, USA
    Blood 97:1975-81. 2001
    ..Blood. 2001;97:1975-1981)..
  9. ncbi request reprint Rac2 stimulates Akt activation affecting BAD/Bcl-XL expression while mediating survival and actin function in primary mast cells
    F C Yang
    Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis 46202, USA
    Immunity 12:557-68. 2000
    ..These results suggest that Rac2 plays a unique role in multiple cellular functions and describe an essential role for Rac2 in growth factor-dependent survival and expression of BAD/Bcl-XL...
  10. pmc Loss of SIMPL compromises TNF-alpha-dependent survival of hematopoietic progenitors
    Eric A Benson
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202 5122, USA
    Exp Hematol 38:71-81. 2010
    ..To address the role of SIMPL in TNF-alpha-dependent signaling in hematopoiesis, endothelial cells and hematopoietic progenitors expressing SIMPL short hairpin RNA were characterized...
  11. pmc Cul4A targets p27 for degradation and regulates proliferation, cell cycle exit, and differentiation during erythropoiesis
    Binghui Li
    Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Blood 107:4291-9. 2006
    ....
  12. pmc Genetic and pharmacologic evidence implicating the p85 alpha, but not p85 beta, regulatory subunit of PI3K and Rac2 GTPase in regulating oncogenic KIT-induced transformation in acute myeloid leukemia and systemic mastocytosis
    Veerendra Munugalavadla
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Blood 110:1612-20. 2007
    ..Taken together, our results identify p85 alpha and Rac2 as potential novel therapeutic targets for the treatment of KITD814V-bearing AML and SM...
  13. ncbi request reprint Role of c-Kit and erythropoietin receptor in erythropoiesis
    Veerendra Munugalavadla
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Cancer Research Building, Indianapolis, IN 46202, USA
    Crit Rev Oncol Hematol 54:63-75. 2005
    ..This review summarizes recent advances made towards understanding the signaling mechanisms by which Epo-R and c-Kit regulate growth, survival, and differentiation of erythroid progenitors alone and cooperatively...
  14. pmc p85alpha subunit of class IA PI-3 kinase is crucial for macrophage growth and migration
    Veerendra Munugalavadla
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Blood 106:103-9. 2005
    ....
  15. ncbi request reprint Deficiency of Src family kinases compromises the repopulating ability of hematopoietic stem cells
    Christie M Orschell
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Exp Hematol 36:655-66. 2008
    ..However, little is known about the role of these kinases in the growth, homing, and engraftment potential of hematopoietic stem and progenitor cells...
  16. pmc The p85alpha subunit of class IA phosphatidylinositol 3-kinase regulates the expression of multiple genes involved in osteoclast maturation and migration
    Veerendra Munugalavadla
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, 2 Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Mol Cell Biol 28:7182-98. 2008
    ..These results highlight the importance of the full-length version of the p85alpha subunit of class I(A) PI3-K in controlling multiple aspects of osteoclast functions...
  17. pmc Genetic reduction of class IA PI-3 kinase activity alters fetal hematopoiesis and competitive repopulating ability of hematopoietic stem cells in vivo
    Laura S Haneline
    Indiana University School of Medicine, Herman B Wells Center for Pediatric Research, Indianapolis, IN 46202, USA
    Blood 107:1375-82. 2006
    ..Collectively, these data identify PI-3K as an important regulator of HSC function and potential therapeutic target in treating leukemic stem cells...
  18. ncbi request reprint K-Ras is essential for normal fetal liver erythropoiesis
    Waleed F Khalaf
    Indiana University School of Medicine, Herman B Wells Center for Pediatric Research, 1044 W Walnut St R4 470, Indianapolis, IN 46202, USA
    Blood 105:3538-41. 2005
    ..Thus, these studies identify K-Ras as a unique Ras isoform that is essential for regulating fetal erythropoiesis in vivo...
  19. pmc c-Kit-mediated overlapping and unique functional and biochemical outcomes via diverse signaling pathways
    Li Hong
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Mol Cell Biol 24:1401-10. 2004
    ..These results argue that SFKs play a unique role in the control of multiple cellular functions and in the activation of distinct biochemical pathways via c-Kit...
  20. ncbi request reprint Thrombopoietin promotes mixed lineage and megakaryocytic colony-forming cell growth but inhibits primitive and definitive erythropoiesis in cells isolated from early murine yolk sacs
    Xiaodong Xie
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis 46202, USA
    Blood 101:1329-35. 2003
    ..Thus, under certain growth factor conditions, Tpo directly inhibits early yolk sac erythroid CFU growth but facilitates megakaryocyte and mixed lineage colony formation...
  21. pmc The protein tyrosine phosphatase, Shp2, positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant disease in vivo
    S C Nabinger
    Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Leukemia 27:398-408. 2013
    ..These findings demonstrate that Shp2 positively contributes to FLT3-ITD-induced leukemia and suggest that Shp2 inhibition may provide a novel therapeutic approach to AML...
  22. pmc Human somatic PTPN11 mutations induce hematopoietic-cell hypersensitivity to granulocyte-macrophage colony-stimulating factor
    Rebecca J Chan
    Herman B Wells Center for Pediatric Research, 1044 W Walnut St, R4 402, Indianapolis, IN 46202, USA
    Blood 105:3737-42. 2005
    ....
  23. doi request reprint Requirement for p85alpha regulatory subunit of class IA PI3K in myeloproliferative disease driven by an activation loop mutant of KIT
    Veerendra Munugalavadla
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Exp Hematol 36:301-8. 2008
    ..Although p85alpha is hyperphosphorylated and constitutively bound to KITD814V in cell-line models; the physiologic significance of this biochemical phenomenon in KITD814V-induced transformation is not known...
  24. ncbi request reprint Genetic evidence for convergence of c-Kit- and alpha4 integrin-mediated signals on class IA PI-3kinase and the Rac pathway in regulating integrin-directed migration in mast cells
    Bai Lin Tan
    Section of Neonatal Perinatal Medicine, Department of Pediatrics, Indiana University School of Medicine, Indianapolis 46202, USA
    Blood 101:4725-32. 2003
    ..These genetic and biochemical data demonstrate that both c-Kit and alpha4 integrin signaling are linked to class IA PI-3kinase and Rac pathways and regulate integrin-directed (haptotactic) migration in mast cells...
  25. pmc Distinct roles of stress-activated protein kinases in Fanconi anemia-type C-deficient hematopoiesis
    M Reza Saadatzadeh
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Blood 113:2655-60. 2009
    ..Taken together, these data suggest that p38 MAPK, but not JNK, has a critical role in maintaining the engraftment of Fancc(-/-)-reconstituting cells under conditions of stress...
  26. pmc ROCK1 functions as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability
    Sasidhar Vemula
    Department of Pediatrics, Indiana University School of Medicine, Herman B Wells Center for Pediatric Research, Indianapolis, USA
    Blood 115:1785-96. 2010
    ..Our results reveal ROCK1 as a physiologic regulator of PTEN whose function is to repress excessive recruitment of macrophages and neutrophils during acute inflammation...
  27. pmc Essential role for focal adhesion kinase in regulating stress hematopoiesis
    Sasidhar Vemula
    Department of Pediatrics, Indiana University School of Medicine, Herman B Wells Center for Pediatric Research, Indianapolis, IN, USA
    Blood 116:4103-15. 2010
    ..Our studies reveal an essential role for FAK in integrating growth/survival and adhesion based functions in myeloid and erythroid cells predominantly under conditions of stress...
  28. ncbi request reprint Rac1 mediates the osteoclast gains-in-function induced by haploinsufficiency of Nf1
    Jincheng Yan
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Hum Mol Genet 17:936-48. 2008
    ..Collectively, these data demonstrate that Rac1 critically contributes to increased osteoclast function induced by haploinsufficiency of Nf1 and implicate Rac1 as a rational therapeutic target for osteoporosis...
  29. pmc Repression of c-kit and its downstream substrates by GATA-1 inhibits cell proliferation during erythroid maturation
    Veerendra Munugalavadla
    Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Cancer Research Institute, 1044 W Walnut Street, Room 425, Indianapolis, IN 46202, USA
    Mol Cell Biol 25:6747-59. 2005
    ..Our findings reveal a novel aspect of molecular cross talk between essential transcriptional and cytokine signaling components of hematopoietic development...
  30. pmc Loss of the nf1 tumor suppressor gene decreases fas antigen expression in myeloid cells
    Kelly Hiatt
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Am J Pathol 164:1471-9. 2004
    ..Thus, therapies designed to decrease p21(ras) activity and up-regulate Fas antigen expression may limit the pathological accumulation of myeloid cells in disease states where p21(ras) is hyperactivated...
  31. doi request reprint Role of intracellular tyrosines in activating KIT-induced myeloproliferative disease
    P Ma
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Leukemia 26:1499-506. 2012
    ..Our results identify critical signaling molecules involved in regulating KITD814V-induced MPD, which might be useful for developing novel therapeutic targets for hematologic malignancies involving this mutation...
  32. ncbi request reprint Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense
    A W Roberts
    Howard Hughes Medical Institute, and Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis 46202, USA
    Immunity 10:183-96. 1999
    ..Rac2 is an essential regulator of multiple specialized neutrophil functions...
  33. ncbi request reprint Xenogeneic expression of human stem cell factor in transgenic mice mimics codominant c-kit mutations
    M K Majumdar
    Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, 46202 5225, USA
    Blood 87:3203-11. 1996
    ..Normal signaling events that lead to cell survival or proliferation appear to be disrupted in vivo in these transgenic mice...
  34. ncbi request reprint Regulation of Th2 cytokine expression in NKT cells: unconventional use of Stat6, GATA-3, and NFAT2
    Zheng Yu Wang
    Department of Microbiology and Immunology and Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Immunol 176:880-8. 2006
    ..Thus, NFAT2, GATA-3, and Stat6 have surprisingly different roles in NKT cells than in conventional T cells. We propose that one mechanism by which CD4+ NKT cells express IL-4 independent of Stat6 is via increased NFAT2 activity...
  35. ncbi request reprint Neurofibromin plays a critical role in modulating osteoblast differentiation of mesenchymal stem/progenitor cells
    Xiaohua Wu
    Department of Pediatrics, Herman B Wells Center for Pediatric Research and Indiana University School of Medicine, Cancer Research Institute, Indianapolis 46202, USA
    Hum Mol Genet 15:2837-45. 2006
    ....
  36. ncbi request reprint The platelet-activating factor receptor activates the extracellular signal-regulated kinase mitogen-activated protein kinase and induces proliferation of epidermal cells through an epidermal growth factor-receptor-dependent pathway
    Silvio A Marques
    Department of Dermatology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Pharmacol Exp Ther 300:1026-35. 2002
    ..In summary, these studies provide a mechanism whereby the PAF-R can exert proliferative effects through the activation of the EGF-R...
  37. ncbi request reprint Functional p85alpha gene is required for normal murine fetal erythropoiesis
    Hannah Huddleston
    Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 W Walnut St, R4 470, Indianapolis, IN 46202, USA
    Blood 102:142-5. 2003
    ..Taken together, these data establish an important role for p85alpha and class IA PI-3 kinase in regulating the development of both early and late erythroid progenitors in fetal liver...
  38. pmc Src family kinase-mediated negative regulation of hematopoietic stem cell mobilization involves both intrinsic and microenvironmental factors
    Jovencio Borneo
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Exp Hematol 35:1026-37. 2007
    ..The intracellular signals that contribute to granulocyte colony-stimulating factor (G-CSF) receptor induced stem cell mobilization are poorly characterized...
  39. pmc Rap1a null mice have altered myeloid cell functions suggesting distinct roles for the closely related Rap1a and 1b proteins
    Yu Li
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis 46202, USA
    J Immunol 179:8322-31. 2007
    ....
  40. pmc Neurofibromin-deficient Schwann cells secrete a potent migratory stimulus for Nf1+/- mast cells
    Feng Chun Yang
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Clin Invest 112:1851-61. 2003
    ..Thus, these studies identify a novel interaction between Nf1-/- Schwann cells and Nf1+/- mast cells that is likely to be important in neurofibroma formation...
  41. pmc Enhanced TNF-alpha-induced apoptosis in Fanconi anemia type C-deficient cells is dependent on apoptosis signal-regulating kinase 1
    Khadijeh Bijangi-Vishehsaraei
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, R4 476, 1044 W Walnut St, Indianapolis, IN 46202, USA
    Blood 106:4124-30. 2005
    ..Collectively, these data argue that the predisposition of Fancc-/- hematopoietic progenitors to apoptosis is mediated in part through altered redox regulation and Ask1 hyperactivation...
  42. pmc T-bet is a critical determinant in the instability of the IL-17-secreting T-helper phenotype
    Anubhav N Mathur
    Department Microbiology and Immunology, Indiana University School of Medicine, 702 Barnhill Dr, RI 2600, Indianapolis, IN 46202, USA
    Blood 108:1595-601. 2006
    ..The transient nature of the Th1beta phenotype suggests that these cells are a component of type I immunity and that T-bet expression is a critical determinant of Th1 versus Th1beta cell fate...
  43. pmc KIT associated intracellular tyrosines play an essential role in EpoR co-signaling
    Li Hong
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA
    Cell Signal 20:1513-20. 2008
    ..In contrast, restoration of the PLC-gamma binding site in the context of Src binding sites appears to antagonize the positive signals induced via the Src kinase binding sites in the KIT receptor...
  44. ncbi request reprint Functional and biochemical consequences of abrogating the activation of multiple diverse early signaling pathways in Kit. Role for Src kinase pathway in Kit-induced cooperation with erythropoietin receptor
    Bai Lin Tan
    Section of Neonatal Perinatal Medicine, Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 278:11686-95. 2003
    ..These data demonstrate an essential role for Src pathway in regulating growth, proliferation, and cooperation with Epo-R downstream from Kit...
  45. pmc Genetic and cellular evidence of vascular inflammation in neurofibromin-deficient mice and humans
    Elisabeth A Lasater
    Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, 46202, USA
    J Clin Invest 120:859-70. 2010
    ....
  46. pmc Balanced interactions between Lyn, the p85alpha regulatory subunit of class I(A) phosphatidylinositol-3-kinase, and SHIP are essential for mast cell growth and maturation
    Peilin Ma
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 W Walnut Street, Indianapolis, IN 46202, USA
    Mol Cell Biol 31:4052-62. 2011
    ..Our results demonstrate a crucial interplay of Lyn, SHIP, and p85α in regulating the normal growth and maturation of BMMCs, in part by regulating the activation of AKT and the expression of Mitf...
  47. ncbi request reprint Lymphoproliferative defects in mice lacking the expression of neurofibromin: functional and biochemical consequences of Nf1 deficiency in T-cell development and function
    David A Ingram
    Section of Neonatal Perinatal Medicine, Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indianapolis, IN 46202, USA
    Blood 100:3656-62. 2002
    ..Collectively, these results identify neurofibromin as a GAP for Ras in T cells for maintaining immune homeostasis in vivo...
  48. ncbi request reprint IL-4-stimulated NF-kappaB activity is required for Stat6 DNA binding
    Vivian T Thieu
    Department of Microbiology and Immunology, Indiana University School of Medicine, and Walther Cancer Institute, Indianapolis, Indiana, USA
    J Leukoc Biol 82:370-9. 2007
    ..These results describe a novel role for NF-kappaB in IL-4-induced signaling and gene expression...
  49. ncbi request reprint Stat3 and Stat4 direct development of IL-17-secreting Th cells
    Anubhav N Mathur
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Immunol 178:4901-7. 2007
    ..The requirements for Stat3 and Stat4 in the development of these IL-17-secreting subsets reveal additional mechanisms in Th cell fate decisions during the generation of proinflammatory cell types...
  50. ncbi request reprint A rare complex DNA rearrangement in the murine Steel gene results in exon duplication and a lethal phenotype
    Saurabh Chandra
    Division of Experimental Hematology, Cincinnati Children s Hospital, Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    Blood 102:3548-55. 2003
    ..The KitlSl-20J mutation is a unique KitlSl allele and represents an unusual mechanism of mutation...
  51. pmc Involvement of Fyn kinase in Kit and integrin-mediated Rac activation, cytoskeletal reorganization, and chemotaxis of mast cells
    Lionel A Samayawardhena
    Department of Biochemistry, Queen s University, Kingston, Ontario, Canada
    Blood 109:3679-86. 2007
    ..Thus, we conclude that Fyn kinase plays a unique role upstream of PI3K and Rac GTPases to promote the reorganization of the cytoskeleton during mast cell spreading and chemotaxis...

Research Grants14

  1. Mechanisms of adhesion and growth control in stem cells
    Reuben Kapur; Fiscal Year: 2004
    ..Our proposed studies will provide unique insights into the physiologic significance of Lyn, Hck, and Fgr SFKs in the regulation of SC/P growth and actin-based functions. ..
  2. Mechanisms of adhesion and growth control in stem cells
    Reuben Kapur; Fiscal Year: 2010
    ..Our proposed studies will provide unique insights into the physiologic significance of the in vivo interactions between class IA PI3K and phosphatases in regulating growth and survival in SC/Ps. ..
  3. Role of Vav and Rac in KIT oncogenesis
    Reuben Kapur; Fiscal Year: 2010
    ..Our results are expected to provide new targets for molecular therapies for the treatment of diseases such as AML and SM. ..
  4. Role of Vav and Rac in KIT oncogenesis
    Reuben Kapur; Fiscal Year: 2009
    ..Our results are expected to provide new targets for molecular therapies for the treatment of diseases such as AML and SM. ..
  5. Novel Mechanisms of C-Kit Regulation in Mast Cells
    Reuben Kapur; Fiscal Year: 2009
    ..abstract_text> ..
  6. Mechanisms of adhesion and growth control in stem cells
    Reuben Kapur; Fiscal Year: 2009
    ..Our proposed studies will provide unique insights into the physiologic significance of the in vivo interactions between class IA PI3K and phosphatases in regulating growth and survival in SC/Ps. ..
  7. Novel Mechanisms of C-Kit Regulation in Mast Cells
    Reuben Kapur; Fiscal Year: 2007
    ..Our proposed studies will provide unique insights into the physiologic significance of the in vivo interactions between SHIP, Lyn and p85 regulatory subunits of class IA PI-3Kinase in regulating all aspects of mast cell biology. ..
  8. Mechanisms of adhesion and growth control in stem cells
    Reuben Kapur; Fiscal Year: 2007
    ..Our proposed studies will provide unique insights into the physiologic significance of Lyn, Hck, and Fgr SFKs in the regulation of SC/P growth and actin-based functions. ..
  9. Novel Mechanisms of C-Kit Regulation in Mast Cells
    Reuben Kapur; Fiscal Year: 2006
    ..Our proposed studies will provide unique insights into the physiologic significance of the in vivo interactions between SHIP, Lyn and p85 regulatory subunits of class IA PI-3Kinase in regulating all aspects of mast cell biology. ..
  10. Mechanisms of adhesion and growth control in stem cells
    Reuben Kapur; Fiscal Year: 2006
    ..Our proposed studies will provide unique insights into the physiologic significance of Lyn, Hck, and Fgr SFKs in the regulation of SC/P growth and actin-based functions. ..
  11. Mechanisms of adhesion and growth control in stem cells
    Reuben Kapur; Fiscal Year: 2005
    ..Our proposed studies will provide unique insights into the physiologic significance of Lyn, Hck, and Fgr SFKs in the regulation of SC/P growth and actin-based functions. ..
  12. Role of Vav and Rac in KIT oncogenesis
    Reuben Kapur; Fiscal Year: 2011
    ..Our results are expected to provide new targets for molecular therapies for the treatment of diseases such as AML and SM. ..