Mark H Kaplan


Affiliation: Indiana University
Country: USA


  1. Olson M, Verdan F, Hufford M, Dent A, Kaplan M. STAT3 Impairs STAT5 Activation in the Development of IL-9-Secreting T Cells. J Immunol. 2016;196:3297-304 pubmed publisher
    ..Thus, STAT3 functions as a negative regulator of IL-9 production through attenuation of STAT5 activation and function. ..
  2. Ulrich B, Verdan F, McKenzie A, Kaplan M, Olson M. STAT3 Activation Impairs the Stability of Th9 Cells. J Immunol. 2017;198:2302-2309 pubmed publisher
    ..Taken together, our results indicate that environmental cues dictate the instability of the Th9 phenotype, and they suggest approaches to enhance Th9 activity in beneficial immune responses. ..
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    Kaplan M. STAT4: a critical regulator of inflammation in vivo. Immunol Res. 2005;31:231-42 pubmed
    ..Comparing the effects of STAT4 deficiency among numerous model systems will further enhance the development of a systemic model of STAT4 function in vivo. ..
  4. Pham D, Sehra S, Sun X, Kaplan M. The transcription factor Etv5 controls TH17 cell development and allergic airway inflammation. J Allergy Clin Immunol. 2014;134:204-14 pubmed publisher
    ..These data define signal transducer and activator of transcription 3-dependent feed-forward control of TH17 cytokine production and a novel role for Etv5 in promoting T cell-dependent airway inflammation. ..
  5. Awe O, Hufford M, Wu H, Pham D, Chang H, Jabeen R, et al. PU.1 Expression in T Follicular Helper Cells Limits CD40L-Dependent Germinal Center B Cell Development. J Immunol. 2015;195:3705-15 pubmed publisher
    ..Together, these data indicate an inhibitory role for PU.1 in the function of Tfh cells, germinal centers, and Tfh-dependent humoral immunity. ..
  6. Sehra S, Yao W, Nguyen E, Glosson Byers N, Akhtar N, Zhou B, et al. TH9 cells are required for tissue mast cell accumulation during allergic inflammation. J Allergy Clin Immunol. 2015;136:433-40.e1 pubmed publisher
    ..TH9 cells are a major source of IL-9 in models of allergic inflammation and play an important role in mast cell accumulation and activation. ..
  7. Koh B, Hufford M, Pham D, Olson M, Wu T, Jabeen R, et al. The ETS Family Transcription Factors Etv5 and PU.1 Function in Parallel To Promote Th9 Cell Development. J Immunol. 2016;197:2465-72 pubmed publisher
    ..Together, these data define a role for ETV5 in Th9 development and extend the paradigm of related transcription factors having complementary functions during differentiation. ..
  8. Koh B, Hufford M, Sun X, Kaplan M. Etv5 Regulates IL-10 Production in Th Cells. J Immunol. 2017;198:2165-2171 pubmed publisher
    ..Taken together, we conclude that Etv5 plays a crucial role in regulating IL-10 production in Th2 cells by facilitating the binding of IL-10-inducing transcription factors at the Il10 locus. ..
  9. Krishnamurthy P, Sherrill J, Parashette K, Goenka S, Rothenberg M, Gupta S, et al. Correlation of increased PARP14 and CCL26 expression in biopsies from children with eosinophilic esophagitis. J Allergy Clin Immunol. 2014;133:577-80 pubmed publisher

More Information


  1. Sehra S, Serezani A, Ocaña J, Travers J, Kaplan M. Mast Cells Regulate Epidermal Barrier Function and the Development of Allergic Skin Inflammation. J Invest Dermatol. 2016;136:1429-1437 pubmed publisher
    ..Together, these studies suggest that mast cells regulate epidermal barrier function and have a potential protective role in the development of atopic dermatitis-like disease. ..
  2. Serezani A, Bozdogan G, Sehra S, Walsh D, Krishnamurthy P, Sierra Potchanant E, et al. IL-4 impairs wound healing potential in the skin by repressing fibronectin expression. J Allergy Clin Immunol. 2017;139:142-151.e5 pubmed publisher
    ..Keratinocyte gene expression is critically shaped by IL-4, altering cell fate decisions, which are likely important for the clinical manifestations and pathology of allergic skin disease. ..
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    Broxmeyer H, Bruns H, Zhang S, Cooper S, Hangoc G, McKenzie A, et al. Th1 cells regulate hematopoietic progenitor cell homeostasis by production of oncostatin M. Immunity. 2002;16:815-25 pubmed
    ..Injection of the Th1 cytokine Oncostatin M but not other cytokines into Stat4-deficient mice recovers progenitor cell activity to wild-type levels. Thus, T helper cells actively regulate hematopoietic progenitor cell homeostasis. ..
  4. Kaplan M, Glosson N, Stritesky G, Yeh N, Kinzfogl J, Rohrabaugh S, et al. STAT3-dependent IL-21 production from T helper cells regulates hematopoietic progenitor cell homeostasis. Blood. 2011;117:6198-201 pubmed publisher
    ..Importantly, injection of IL-21 rescued HPC activity in mice with STAT3-deficient T cells. Thus, STAT3-dependent IL-21 production in T cells is required for HPC homeostasis. ..
  5. Sehra S, Krishnamurthy P, Koh B, Zhou H, Seymour L, Akhtar N, et al. Increased Th2 activity and diminished skin barrier function cooperate in allergic skin inflammation. Eur J Immunol. 2016;46:2609-2613 pubmed publisher
    ..Our study suggests that skin barrier defects and altered Th2 responses independently cooperate in the pathogenesis of allergic skin inflammation, similar to effects observed in patients with AD. ..