H L June

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. ncbi request reprint The GABA(A) receptor alpha1 subtype in the ventral pallidum regulates alcohol-seeking behaviors
    Scott C Harvey
    Laboratory of Neuroscience, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Neurosci 22:3765-75. 2002
  2. ncbi request reprint The reinforcing properties of alcohol are mediated by GABA(A1) receptors in the ventral pallidum
    Harry L June
    Psychobiology Program, Department of Psychology, Indiana University Purdue University, Indianapolis, IN 46202, USA
    Neuropsychopharmacology 28:2124-37. 2003
  3. ncbi request reprint GABA(A) receptors containing (alpha)5 subunits in the CA1 and CA3 hippocampal fields regulate ethanol-motivated behaviors: an extended ethanol reward circuitry
    H L June
    Psychobiology Program, Department of Psychology, Indiana University Purdue University, Indianapolis, Indiana 46202, USA
    J Neurosci 21:2166-77. 2001
  4. ncbi request reprint The effects of the novel benzodiazepine receptor inverse agonist Ru 34000 on ethanol-maintained behaviors
    H L June
    Department of Psychology, Indiana University Purdue University, Purdue School of Science, Indianapolis 46202, USA
    Eur J Pharmacol 350:151-8. 1998
  5. ncbi request reprint GABAA-benzodiazepine receptors in the striatum are involved in the sedation produced by a moderate, but not an intoxicating ethanol dose in outbred Wistar rats
    H L June
    Department of Psychology, Purdue School of Science, Indiana University Purdue University, Indianapolis, IN 46202, USA
    Brain Res 794:103-18. 1998
  6. ncbi request reprint Benzodiazepine receptor antagonists modulate the actions of ethanol in alcohol-preferring and -nonpreferring rats
    H L June
    Department of Psychology, Indiana University School of Medicine, Indiana University Purdue University, Indianapolis 46202 3275, USA
    Eur J Pharmacol 342:139-51. 1998
  7. ncbi request reprint High-affinity benzodiazepine antagonists reduce responding maintained by ethanol presentation in ethanol-preferring rats
    H L June
    Department of Psychology, Purdue School of Science, Indiana University Purdue University, Indianapolis, USA
    J Pharmacol Exp Ther 284:1006-14. 1998
  8. ncbi request reprint Effects of the benzodiazepine inverse agonist RO19-4603 alone and in combination with the benzodiazepine receptor antagonists flumazenil, ZK 93426 and CGS 8216, on ethanol intake in alcohol-preferring (P) rats
    H L June
    Department of Psychology, Purdue School of Science, Indiana University Purdue University, Indianapolis 46202, USA
    Brain Res 734:19-34. 1996
  9. ncbi request reprint GABA(A) and opioid receptors of the central nucleus of the amygdala selectively regulate ethanol-maintained behaviors
    Katrina L Foster
    Psychobiology Program, Department of Psychology, Indiana University Purdue University, Indianapolis, IN, USA
    Neuropsychopharmacology 29:269-84. 2004
  10. ncbi request reprint A high affinity ligand for GABAA-receptor containing alpha5 subunit antagonizes ethanol's neurobehavioral effects in Long-Evans rats
    Peter F McKay
    Psychobiology Program, Department of Psychology, Indiana University Purdue University, Indianapolis, IN 46202, USA
    Psychopharmacology (Berl) 172:455-62. 2004

Collaborators

Detail Information

Publications20

  1. ncbi request reprint The GABA(A) receptor alpha1 subtype in the ventral pallidum regulates alcohol-seeking behaviors
    Scott C Harvey
    Laboratory of Neuroscience, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Neurosci 22:3765-75. 2002
    ..These receptors represent novel targets in the design and development of pharmacotherapies for alcohol-dependent subjects...
  2. ncbi request reprint The reinforcing properties of alcohol are mediated by GABA(A1) receptors in the ventral pallidum
    Harry L June
    Psychobiology Program, Department of Psychology, Indiana University Purdue University, Indianapolis, IN 46202, USA
    Neuropsychopharmacology 28:2124-37. 2003
    ..These anti-alcohol properties of betaCCt are primarily mediated via the GABA(A1) receptor. betaCCt may represent a prototype of a pharmacotherapeutic agent to effectively reduce alcohol drinking behavior in human alcoholics...
  3. ncbi request reprint GABA(A) receptors containing (alpha)5 subunits in the CA1 and CA3 hippocampal fields regulate ethanol-motivated behaviors: an extended ethanol reward circuitry
    H L June
    Psychobiology Program, Department of Psychology, Indiana University Purdue University, Indianapolis, Indiana 46202, USA
    J Neurosci 21:2166-77. 2001
    ..The results provide the first demonstration that the alpha5-containing GABA(A) receptors in the hippocampus play an important role in regulating EtOH-seeking behaviors...
  4. ncbi request reprint The effects of the novel benzodiazepine receptor inverse agonist Ru 34000 on ethanol-maintained behaviors
    H L June
    Department of Psychology, Indiana University Purdue University, Purdue School of Science, Indianapolis 46202, USA
    Eur J Pharmacol 350:151-8. 1998
    ..Low affinity imidazopyrimidines may be useful pharmacological probes to further understand the role of the GABA(A)-benzodiazepine receptor complex in ethanol motivated behaviors...
  5. ncbi request reprint GABAA-benzodiazepine receptors in the striatum are involved in the sedation produced by a moderate, but not an intoxicating ethanol dose in outbred Wistar rats
    H L June
    Department of Psychology, Purdue School of Science, Indiana University Purdue University, Indianapolis, IN 46202, USA
    Brain Res 794:103-18. 1998
    ..The results suggest that central GABAA-BDZ receptors in the dorsal striatum play an important role in mediating the sedation produced by a moderate EtOH dose in the open field...
  6. ncbi request reprint Benzodiazepine receptor antagonists modulate the actions of ethanol in alcohol-preferring and -nonpreferring rats
    H L June
    Department of Psychology, Indiana University School of Medicine, Indiana University Purdue University, Indianapolis 46202 3275, USA
    Eur J Pharmacol 342:139-51. 1998
    ..The findings indicate the potential for development of receptor specific ligands devoid of toxic effects which may be useful in the treatment of alcohol abuse and alcoholism...
  7. ncbi request reprint High-affinity benzodiazepine antagonists reduce responding maintained by ethanol presentation in ethanol-preferring rats
    H L June
    Department of Psychology, Purdue School of Science, Indiana University Purdue University, Indianapolis, USA
    J Pharmacol Exp Ther 284:1006-14. 1998
    ..These findings demonstrate that some BDZ antagonists decrease responding maintained by EtOH. The findings suggest that certain BDZ antagonists may have potential as pharmacotherapies to prevent or decrease EtOH abuse in humans...
  8. ncbi request reprint Effects of the benzodiazepine inverse agonist RO19-4603 alone and in combination with the benzodiazepine receptor antagonists flumazenil, ZK 93426 and CGS 8216, on ethanol intake in alcohol-preferring (P) rats
    H L June
    Department of Psychology, Purdue School of Science, Indiana University Purdue University, Indianapolis 46202, USA
    Brain Res 734:19-34. 1996
    ..That certain BDZ inverse agonists can attenuate motivated behavior for EtOH reinforcement over a prolonged time course may provide a possible therapeutic approach to reducing EtOH consumption associated with alcoholism...
  9. ncbi request reprint GABA(A) and opioid receptors of the central nucleus of the amygdala selectively regulate ethanol-maintained behaviors
    Katrina L Foster
    Psychobiology Program, Department of Psychology, Indiana University Purdue University, Indianapolis, IN, USA
    Neuropsychopharmacology 29:269-84. 2004
    ..The CeA may represent a novel target site in the development of prototypical GABA(A) and opioidergic receptor ligands, which selectively reduce alcohol abuse in humans...
  10. ncbi request reprint A high affinity ligand for GABAA-receptor containing alpha5 subunit antagonizes ethanol's neurobehavioral effects in Long-Evans rats
    Peter F McKay
    Psychobiology Program, Department of Psychology, Indiana University Purdue University, Indianapolis, IN 46202, USA
    Psychopharmacology (Berl) 172:455-62. 2004
    ..However, the role of the alpha(5) receptor in regulating the neurobehavioral effects of EtOH in outbred rats is not known...
  11. ncbi request reprint Central opioid receptors differentially regulate the nalmefene-induced suppression of ethanol- and saccharin-reinforced behaviors in alcohol-preferring (P) rats
    Harry L June
    Psychobiology of Addictions Program, Department of Psychology, Indiana University Purdue University, Indianapolis, IN, USA
    Neuropsychopharmacology 29:285-99. 2004
    ....
  12. ncbi request reprint D1 dopamine receptor regulates alcohol-motivated behaviors in the bed nucleus of the stria terminalis in alcohol-preferring (P) rats
    William J A Eiler
    Psychobiology Program, Department of Psychology, Indiana University Purdue University, Indianapolis, Indiana 46202 3275, USA
    Synapse 48:45-56. 2003
    ..The results suggest a salient role for the D(1), but not the D(2) and opioid receptors in selectively modulating EtOH-motivated behaviors in the BST...
  13. ncbi request reprint Selective GABAA alpha5 benzodiazepine inverse agonist antagonizes the neurobehavioral actions of alcohol
    Jason B Cook
    Psychobiology Program, Department of Psychology, Indiana University Purdue University, Indianapolis, Indiana 46202 3275, USA
    Alcohol Clin Exp Res 29:1390-401. 2005
    ..g., RY 023) was used in a series of in vivo and in vitro studies to determine the significance of the alpha5-receptor in the neurobehavioral actions of alcohol...
  14. pmc Blockade of GABA(A) receptors within the extended amygdala attenuates D(2) regulation of alcohol-motivated behaviors in the ventral tegmental area of alcohol-preferring (P) rats
    William J A Eiler
    Psychobiology of Addictions Program, Department of Psychology, Indiana University Purdue University, Indianapolis, IN 46202, USA
    Neuropharmacology 52:1570-9. 2007
    ..These results suggest that while the D2 receptors within the VTA regulate EtOH-motivated behaviors, this is modulated by GABAergic input from the mesolimbic forebrain, specifically from the BST and NAcc...
  15. doi request reprint Preclinical models to evaluate potential pharmacotherapeutic agents in treating alcoholism and studying the neuropharmacological bases of ethanol-seeking behaviors in rats
    Harry L June
    Indiana University Purdue University, Indianapolis, Indiana, USA
    Curr Protoc Neurosci . 2002
    ..Also included are procedures designed to study the neural mechanisms regulating alcohol-seeking behaviors...
  16. ncbi request reprint Brain stimulation reward performance and sucrose maintained behaviors in alcohol-preferring and -nonpreferring rats
    William J A Eiler
    Psychobiology of Addictions Program, Department of Psychology, Indiana University Purdue University, Indianapolis, Indiana 46202 3275, USA
    Alcohol Clin Exp Res 29:571-83. 2005
    ..For comparison, the study also examined the relation between EtOH preference and motivation for a sweet, palatable sucrose solution under similar schedules of reinforcement...
  17. ncbi request reprint Decreased reward during acute alcohol withdrawal in rats selectively bred for low alcohol drinking
    Julia A Chester
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Alcohol 38:165-72. 2006
    ..The results suggest that rats selectively bred for low alcohol drinking may experience dysphoric-like effects during withdrawal from an initial exposure to alcohol, while rats selectively bred for high alcohol drinking may not...
  18. ncbi request reprint Responding for brain stimulation reward in the bed nucleus of the stria terminalis in alcohol-preferring rats following alcohol and amphetamine pretreatments
    William J A Eiler
    Psychobiology of Addictions Program, Department of Psychology, Indiana University Purdue University, Indianapolis, Indiana 46202, USA
    Synapse 61:912-24. 2007
    ....
  19. ncbi request reprint Differential responding for brain stimulation reward and sucrose in high-alcohol-drinking (HAD) and low-alcohol-drinking (LAD) rats
    James E Woods
    Department of Psychology, Purdue School of Science, Indianapolis, IN 46202 4887, USA
    Alcohol Clin Exp Res 27:926-36. 2003
    ....
  20. ncbi request reprint Dopamine and benzodiazepine-dependent mechanisms regulate the EtOH-enhanced locomotor stimulation in the GABAA alpha1 subunit null mutant mice
    Harry L June
    Division of Alcohol and Drug Abuse, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Neuropsychopharmacology 32:137-52. 2007
    ..Deleting the alpha1 subunit of the GABA(A) receptor appears to unmask alcohol's stimulatory effects; these effects appear to be regulated via an interaction of both DA- and GABA(A) BDZ-dependent mechanisms...