Roger W Innes

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. ncbi request reprint Activation of plant nod-like receptors: how indirect can it be?
    Roger W Innes
    Department of Biology, Indiana University, Bloomington, 47405, USA
    Cell Host Microbe 9:87-9. 2011
  2. pmc Differential accumulation of retroelements and diversification of NB-LRR disease resistance genes in duplicated regions following polyploidy in the ancestor of soybean
    Roger W Innes
    Department of Biology, Indiana University, Bloomington, Indiana 47405, USA
    Plant Physiol 148:1740-59. 2008
  3. pmc Guarding the goods. New insights into the central alarm system of plants
    Roger W Innes
    Department of Biology, Indiana University, Bloomington, Indiana 47405 7107, USA
    Plant Physiol 135:695-701. 2004
  4. ncbi request reprint New effects of type III effectors
    Roger Innes
    Department of Biology, Indiana University, Bloomington, IN 47405 7107, USA
    Mol Microbiol 50:363-5. 2003
  5. pmc Replication of nonautonomous retroelements in soybean appears to be both recent and common
    Adam Wawrzynski
    Department of Biology, Indiana University, Bloomington, Indiana 47405, USA
    Plant Physiol 148:1760-71. 2008
  6. pmc The KEEP ON GOING protein of Arabidopsis regulates intracellular protein trafficking and is degraded during fungal infection
    Yangnan Gu
    Department of Biology, Indiana University, Bloomington, Indiana 47405, USA
    Plant Cell 24:4717-30. 2012
  7. pmc Evolution of a complex disease resistance gene cluster in diploid Phaseolus and tetraploid Glycine
    Tom Ashfield
    Department of Biology, Indiana University, Bloomington, Indiana 47405, USA
    Plant Physiol 159:336-54. 2012
  8. pmc Synergistic activation of defense responses in Arabidopsis by simultaneous loss of the GSL5 callose synthase and the EDR1 protein kinase
    Anna Wawrzynska
    Indiana University, Bloomington, IN 47405, USA
    Mol Plant Microbe Interact 23:578-84. 2010
  9. pmc Regulation of plant disease resistance, stress responses, cell death, and ethylene signaling in Arabidopsis by the EDR1 protein kinase
    Dingzhong Tang
    Department of Biology, Indiana University, Bloomington, Indiana 47405 7107, USA
    Plant Physiol 138:1018-26. 2005
  10. pmc A mutation in the GTP hydrolysis site of Arabidopsis dynamin-related protein 1E confers enhanced cell death in response to powdery mildew infection
    Dingzhong Tang
    Department of Biology, Indiana University, Bloomington, IN 47405, USA
    Plant J 47:75-84. 2006

Collaborators

  • Dingzhong Tang
  • Nevin D Young
  • Ashley N Egan
  • Jeff J Doyle
  • Valerie Geffroy
  • Jing Yi
  • Steven B Cannon
  • Pablo Tornero
  • David A Lightfoot
  • Zhongying Chen
  • Khalid Meksem
  • Barbara N Kunkel
  • Ken Shirasu
  • John M McDowell
  • Sun Kim
  • JEFFERY DANGL
  • Brody J DeYoung
  • Tom Ashfield
  • Dong Qi
  • Yangnan Gu
  • Anna Wawrzynska
  • Feng Shao
  • Jack E Dixon
  • Katy M Christiansen
  • Jules Ade
  • Laura E Ong
  • Kan Nobuta
  • Carine Ameline-Torregrosa
  • Bruce A Roe
  • Ram Podicheti
  • Milind B Ratnaparkhe
  • M A Saghai Maroof
  • Roxanne Denny
  • Bernard E Pfeil
  • Nicolas W G Chen
  • Natalie L Rodibaugh
  • Adam Wawrzynski
  • Catherine Golstein
  • Minfeng Zhu
  • D Isaiah Sloss
  • Robert H Dowen
  • Ullrich Dubiella
  • Thomas P Burke
  • Natalie Rodibaugh
  • Dominic M Tucker
  • Natasha Glover
  • Yinan Lan
  • Anita Dalwani
  • Sara Martin Del Campo
  • Arnaud Couloux
  • Iryna Sanders
  • Majesta O'Bleness
  • Michelle Metcalf
  • Shweta Deshpande
  • Ethalinda Cannon
  • Sylvie Samain
  • Dan Ilut
  • Hongshing Lai
  • Vincent Thareau
  • Ashley Nguyen
  • Sue Sherman-Broyles
  • Beatrice Segurens
  • Ben Chacko
  • Jafar Mammadov
  • Stacy Howell
  • Mireille Sévignac
  • Christopher M Schneider
  • Zhaohui Xu
  • Adam D Henk
  • Dan Held
  • Silvia Penuela
  • Mark Stoutemyer
  • Dariush Danesh
  • Laura Fredrick Marek
  • Anna Bocian
  • Randy C Shoemaker
  • Peter M Merritt
  • Zhaoqin Bao

Detail Information

Publications32

  1. ncbi request reprint Activation of plant nod-like receptors: how indirect can it be?
    Roger W Innes
    Department of Biology, Indiana University, Bloomington, 47405, USA
    Cell Host Microbe 9:87-9. 2011
    ..In this issue, two groups show that the RPM1 NLR is activated by phosphorylation of the host protein RIN4, probably resulting from activation of a host kinase by pathogen effectors...
  2. pmc Differential accumulation of retroelements and diversification of NB-LRR disease resistance genes in duplicated regions following polyploidy in the ancestor of soybean
    Roger W Innes
    Department of Biology, Indiana University, Bloomington, Indiana 47405, USA
    Plant Physiol 148:1740-59. 2008
    ....
  3. pmc Guarding the goods. New insights into the central alarm system of plants
    Roger W Innes
    Department of Biology, Indiana University, Bloomington, Indiana 47405 7107, USA
    Plant Physiol 135:695-701. 2004
  4. ncbi request reprint New effects of type III effectors
    Roger Innes
    Department of Biology, Indiana University, Bloomington, IN 47405 7107, USA
    Mol Microbiol 50:363-5. 2003
    ..This work is providing some of the first insights into how plant pathogens subvert host cell signalling machinery to cause disease...
  5. pmc Replication of nonautonomous retroelements in soybean appears to be both recent and common
    Adam Wawrzynski
    Department of Biology, Indiana University, Bloomington, Indiana 47405, USA
    Plant Physiol 148:1760-71. 2008
    ..The impact of nonautonomous retrotransposon replication on genome size appears to be much greater than previously appreciated...
  6. pmc The KEEP ON GOING protein of Arabidopsis regulates intracellular protein trafficking and is degraded during fungal infection
    Yangnan Gu
    Department of Biology, Indiana University, Bloomington, Indiana 47405, USA
    Plant Cell 24:4717-30. 2012
    ....
  7. pmc Evolution of a complex disease resistance gene cluster in diploid Phaseolus and tetraploid Glycine
    Tom Ashfield
    Department of Biology, Indiana University, Bloomington, Indiana 47405, USA
    Plant Physiol 159:336-54. 2012
    ..We conclude that while polyploidization in Glycine has not driven a stable increase in family size for NB-LRR genes, it has generated two recombinationally isolated clusters, one of which appears to be in the process of decay...
  8. pmc Synergistic activation of defense responses in Arabidopsis by simultaneous loss of the GSL5 callose synthase and the EDR1 protein kinase
    Anna Wawrzynska
    Indiana University, Bloomington, IN 47405, USA
    Mol Plant Microbe Interact 23:578-84. 2010
    ..Our data suggest that EDR1 and GSL5 negatively regulate SA and JA production or signaling by independent mechanisms and that negative regulation of defense signaling by GSL5 may be independent of callose production...
  9. pmc Regulation of plant disease resistance, stress responses, cell death, and ethylene signaling in Arabidopsis by the EDR1 protein kinase
    Dingzhong Tang
    Department of Biology, Indiana University, Bloomington, Indiana 47405 7107, USA
    Plant Physiol 138:1018-26. 2005
    ....
  10. pmc A mutation in the GTP hydrolysis site of Arabidopsis dynamin-related protein 1E confers enhanced cell death in response to powdery mildew infection
    Dingzhong Tang
    Department of Biology, Indiana University, Bloomington, IN 47405, USA
    Plant J 47:75-84. 2006
    ..These observations suggest a mechanistic link between salicylic acid signaling, mitochondria and programmed cell death in plants...
  11. pmc Convergent evolution of disease resistance gene specificity in two flowering plant families
    Tom Ashfield
    Department of Biology, Indiana University, Bloomington, Indiana 47405 7107, USA
    Plant Cell 16:309-18. 2004
    ..We conclude that convergent evolution, rather than the conservation of an ancient specificity, is responsible for the generation of these AvrB-specific genes...
  12. pmc Activation of a plant nucleotide binding-leucine rich repeat disease resistance protein by a modified self protein
    Brody J DeYoung
    Department of Biology, Indiana University, Bloomington, Indiana, USA
    Cell Microbiol 14:1071-84. 2012
    ..This finding suggests that NB-LRR proteins may function as fine-tuned sensors of alterations in the structures of effector targets...
  13. pmc Structure-function analysis of the coiled-coil and leucine-rich repeat domains of the RPS5 disease resistance protein
    Dong Qi
    Department of Biology, Indiana University, Bloomington, Indiana 47405, USA
    Plant Physiol 158:1819-32. 2012
    ..We conclude that the RPS5 LRR domain functions to suppress RPS5 activation in the absence of PBS1 cleavage and promotes RPS5 activation in its presence...
  14. ncbi request reprint AvrB mutants lose both virulence and avirulence activities on soybean and Arabidopsis
    Laura E Ong
    Department of Biology, Indiana University, Bloomington, IN 47405, USA
    Mol Microbiol 60:951-62. 2006
    ..Our results suggest that soybean and Arabidopsis recognize AvrB in the same manner, and that AvrB enzymatic activity is required for its function as an avirulence and virulence effector on two different plant species...
  15. ncbi request reprint The Pseudomonas syringae type III effector AvrRpt2 functions downstream or independently of SA to promote virulence on Arabidopsis thaliana
    Zhongying Chen
    Department of Biology, Washington University in St Louis, St Louis, MO 63130, USA
    Plant J 37:494-504. 2004
    ..Additionally, avrRpt2 transgenic plants did not exhibit increased susceptibility to Peronospora parasitica and Erysiphe cichoracearum, suggesting that AvrRpt2 virulence activity is specific to P. syringae...
  16. ncbi request reprint Diversification of non-TIR class NB-LRR genes in relation to whole-genome duplication events in Arabidopsis
    Kan Nobuta
    Department of Biology, Indiana University, Bloomington, IN 47405, USA
    Mol Plant Microbe Interact 18:103-9. 2005
    ....
  17. pmc Regulation of plant defense responses in Arabidopsis by EDR2, a PH and START domain-containing protein
    Dingzhong Tang
    Department of Biology, Indiana University, Bloomington, IN 47405, USA
    Plant J 44:245-57. 2005
    ..The PH and START domains are implicated in lipid binding, suggesting that EDR2 may provide a link between lipid signaling and activation of programmed cell death mediated by mitochondria...
  18. pmc Mutations in LACS2, a long-chain acyl-coenzyme A synthetase, enhance susceptibility to avirulent Pseudomonas syringae but confer resistance to Botrytis cinerea in Arabidopsis
    Dingzhong Tang
    Department of Biology, Indiana University, Bloomington, Indiana 47405, USA
    Plant Physiol 144:1093-103. 2007
    ..All three displayed an enhanced resistance to B. cinerea. Our results indicate that plant cutin or cuticle structure may play a crucial role in tolerance to biotic and abiotic stress and in the pathogenesis of B. cinerea...
  19. pmc Negative regulation of defence signalling pathways by the EDR1 protein kinase
    Katy M Christiansen
    Indiana University, Bloomington, IN 47405, USA
    Mol Plant Pathol 12:746-58. 2011
    ....
  20. pmc Powdery mildew resistance conferred by loss of the ENHANCED DISEASE RESISTANCE1 protein kinase is suppressed by a missense mutation in KEEP ON GOING, a regulator of abscisic acid signaling
    Anna Wawrzynska
    Department of Biology, Indiana University, Bloomington, Indiana 47405, USA
    Plant Physiol 148:1510-22. 2008
    ..We conclude that edr1-mediated resistance to powdery mildew is mediated, in part, by enhanced ABA signaling...
  21. ncbi request reprint Overexpression of a kinase-deficient form of the EDR1 gene enhances powdery mildew resistance and ethylene-induced senescence in Arabidopsis
    Dingzhong Tang
    Department of Biology, Indiana University, Bloomington, IN 47405 7107, USA
    Plant J 32:975-83. 2002
    ..Overexpression of orthologous dnEDR1 constructs may provide a novel strategy for controlling powdery mildew disease in crops...
  22. pmc Indirect activation of a plant nucleotide binding site-leucine-rich repeat protein by a bacterial protease
    Jules Ade
    Department of Biology, Indiana University, Bloomington, IN 47405 7107, USA
    Proc Natl Acad Sci U S A 104:2531-6. 2007
    ..Combined, these data suggest that ATP versus ADP binding functions as a molecular switch that is flipped by cleavage of PBS1...
  23. pmc Plant NBS-LRR proteins in pathogen sensing and host defense
    Brody J DeYoung
    Department of Biology, Indiana University, Bloomington, Indiana 47405, USA
    Nat Immunol 7:1243-9. 2006
    ..Such conformational alterations are thought to promote the exchange of ADP for ATP by the NBS domain, which activates 'downstream' signaling, by an unknown mechanism, leading to pathogen resistance...
  24. ncbi request reprint The rules of engagement. The XIII International Congress on Molecular Plant-Microbe Interactions, Sorrento, Italy, July 2007
    Brody J DeYoung
    Department of Biology, Indiana University, Bloomington, IN 47405, USA
    New Phytol 176:506-10. 2007
  25. ncbi request reprint Genetic and physical localization of the soybean Rpg1-b disease resistance gene reveals a complex locus containing several tightly linked families of NBS-LRR genes
    Tom Ashfield
    Department of Biology, Indiana University, Bloomington, IN 47405, USA
    Mol Plant Microbe Interact 16:817-26. 2003
    ..At least five CC-NBS-LRR-type genes cosegregate with Rpg1-b in our large mapping populations...
  26. pmc The KEEP ON GOING protein of Arabidopsis recruits the ENHANCED DISEASE RESISTANCE1 protein to trans-Golgi network/early endosome vesicles
    Yangnan Gu
    Department of Biology, Indiana University, Bloomington, Indiana 47405 7107, USA
    Plant Physiol 155:1827-38. 2011
    ..Collectively, these data suggest that EDR1 and KEG function together to regulate endocytic trafficking and/or the formation of signaling complexes on TGN/EE vesicles during stress responses...
  27. pmc Recognition of the protein kinase AVRPPHB SUSCEPTIBLE1 by the disease resistance protein RESISTANCE TO PSEUDOMONAS SYRINGAE5 is dependent on s-acylation and an exposed loop in AVRPPHB SUSCEPTIBLE1
    Dong Qi
    Department of Biology, Indiana University, Bloomington, Indiana 47405
    Plant Physiol 164:340-51. 2014
    ..These findings provide support for a model of NLR activation in which NLR proteins form a preactivation complex with effector targets and then sense a conformational change in the target induced by effector modification. ..
  28. pmc RAR1 and NDR1 contribute quantitatively to disease resistance in Arabidopsis, and their relative contributions are dependent on the R gene assayed
    Pablo Tornero
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Plant Cell 14:1005-15. 2002
    ..In Atrar1 null plants, the levels of RPM1-myc are reduced severely, suggesting that AtRAR1 may regulate R protein stability or accumulation...
  29. ncbi request reprint Cleavage of Arabidopsis PBS1 by a bacterial type III effector
    Feng Shao
    Department of Biological Chemistry, Medical School and Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA
    Science 301:1230-3. 2003
    ..AvrPphB was found to proteolytically cleave PBS1, and this cleavage was required for RPS5-mediated resistance, which indicates that AvrPphB is detected indirectly via its enzymatic activity...
  30. pmc The crystal structure of Pseudomonas avirulence protein AvrPphB: a papain-like fold with a distinct substrate-binding site
    Minfeng Zhu
    Department of Biological Chemistry, Medical School and Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 101:302-7. 2004
    ..Further implications about the specificity of plant pathogen recognition are also discussed...
  31. ncbi request reprint A Yersinia effector and a Pseudomonas avirulence protein define a family of cysteine proteases functioning in bacterial pathogenesis
    Feng Shao
    Department of Biological Chemistry, Medical School and Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA
    Cell 109:575-88. 2002
    ..These findings provide new insights into mechanisms of animal and plant pathogenesis...

Research Grants26

  1. Programmed Cell Death and Disease Resistance in Arabidopsis
    Roger Innes; Fiscal Year: 2007
    ....
  2. GENETICS OF DISEASE RESISTANCE IN ARABIDOPSIS THALIANA
    Roger Innes; Fiscal Year: 2007
    ..In addition, the defense pathways regulated by PBS1 will be identified using Affymetrix GeneChip analysis, and putative substrates of PBS1 will be identified using a split ubiquitin yeast two-hybrid screen. ..
  3. Programmed Cell Death and Disease Resistance in Arabidopsis
    Roger Innes; Fiscal Year: 2009
    ..abstract_text> ..
  4. GENETICS OF DISEASE RESISTANCE IN ARABIDOPSIS THALIANA
    Roger W Innes; Fiscal Year: 2010
    ..By studying at a molecular level, how these proteins function, this research will lead to new treatments for autoimmune diseases, and new approaches to breeding disease resistant crops. ..
  5. Programmed Cell Death and Disease Resistance in Arabidopsis
    Roger W Innes; Fiscal Year: 2010
    ..Understanding how cells decide to live or die is critical to our understanding of cancer and autoimmune diseases. ..
  6. Analysis of the EDRI MAPKKK Pathway in Plants
    Roger Innes; Fiscal Year: 2005
    ..This information, in turn, may provide new insights into the regulation of programmed cell death in plants and the overlap between normal senescence processes and pathogen defense. ..
  7. GENETICS OF DISEASE RESISTANCE IN ARABIDOPSIS THALIANA
    Roger Innes; Fiscal Year: 1999
    ..Two hybrid clones that do not correspond to any known gene will be assayed for biological activity in Arabidopsis using a genetic suppression assay. ..
  8. GENETICS OF DISEASE RESISTANCE IN ARABIDOPSIS THALIANA
    Roger Innes; Fiscal Year: 2003
    ..These experiments will advance understanding of how interactions of plant R genes and pathogen avr genes lead to disease resistance. ..
  9. GENETICS OF DISEASE RESISTANCE IN ARABIDOPSIS THALIANA
    Roger W Innes; Fiscal Year: 2010
    ..By studying at a molecular level, how these proteins function, this research will lead to new treatments for autoimmune diseases, and new approaches to breeding disease resistant crops. ..