David A Ingram

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. ncbi request reprint Rac2 concentrations in umbilical cord neutrophils
    Virginia M Meade
    Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Biol Neonate 90:156-9. 2006
  2. pmc Redefining endothelial progenitor cells via clonal analysis and hematopoietic stem/progenitor cell principals
    Mervin C Yoder
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis 46202, USA
    Blood 109:1801-9. 2007
  3. pmc Genetic and cellular evidence of vascular inflammation in neurofibromin-deficient mice and humans
    Elisabeth A Lasater
    Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, 46202, USA
    J Clin Invest 120:859-70. 2010
  4. ncbi request reprint Leukemic potential of doubly mutant Nf1 and Wv hematopoietic cells
    David A Ingram
    Indiana University School of Medicine, Herman B Wells Center for Pediatric Research, Department of Microbiology Immunology, Indianapolis, IN 46202, USA
    Blood 101:1984-6. 2003
  5. ncbi request reprint Vessel wall-derived endothelial cells rapidly proliferate because they contain a complete hierarchy of endothelial progenitor cells
    David A Ingram
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 W Walnut St R4 470, Indianapolis, IN 46202, USA
    Blood 105:2783-6. 2005
  6. ncbi request reprint Identification of a novel hierarchy of endothelial progenitor cells using human peripheral and umbilical cord blood
    David A Ingram
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis 46202, USA
    Blood 104:2752-60. 2004
  7. pmc Pak1 regulates multiple c-Kit mediated Ras-MAPK gain-in-function phenotypes in Nf1+/- mast cells
    ANDREW S MCDANIEL
    Department of Microbiology and Immunology, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis 46202, USA
    Blood 112:4646-54. 2008
  8. doi request reprint Isolation and characterization of endothelial progenitor cells from human blood
    Laura E Mead
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Curr Protoc Stem Cell Biol . 2008
  9. pmc Nf1-dependent tumors require a microenvironment containing Nf1+/-- and c-kit-dependent bone marrow
    Feng Chun Yang
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Cell 135:437-48. 2008
  10. pmc Hyperactivation of p21ras and PI3K cooperate to alter murine and human neurofibromatosis type 1-haploinsufficient osteoclast functions
    Feng Chun Yang
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Clin Invest 116:2880-91. 2006

Research Grants

Collaborators

Detail Information

Publications57

  1. ncbi request reprint Rac2 concentrations in umbilical cord neutrophils
    Virginia M Meade
    Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Biol Neonate 90:156-9. 2006
    ..Since human subjects and mice deficient in Rac2 display deficiencies in neutrophil functions similar to newborn infants, we postulated that newborn neutrophils may be deficient in Rac2...
  2. pmc Redefining endothelial progenitor cells via clonal analysis and hematopoietic stem/progenitor cell principals
    Mervin C Yoder
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis 46202, USA
    Blood 109:1801-9. 2007
    ..Thus, these studies establish that CFU-ECs are not EPCs and the role of these cells in angiogenesis must be re-examined prior to further clinical trials, whereas ECFCs may serve as a potential therapy for vascular regeneration...
  3. pmc Genetic and cellular evidence of vascular inflammation in neurofibromin-deficient mice and humans
    Elisabeth A Lasater
    Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, 46202, USA
    J Clin Invest 120:859-70. 2010
    ....
  4. ncbi request reprint Leukemic potential of doubly mutant Nf1 and Wv hematopoietic cells
    David A Ingram
    Indiana University School of Medicine, Herman B Wells Center for Pediatric Research, Department of Microbiology Immunology, Indianapolis, IN 46202, USA
    Blood 101:1984-6. 2003
    ..Despite a reduction in c-kit activity to approximately 10% of wild-type levels, Nf1-/-;Wv/Wv cells induced MPD in recipient mice...
  5. ncbi request reprint Vessel wall-derived endothelial cells rapidly proliferate because they contain a complete hierarchy of endothelial progenitor cells
    David A Ingram
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 W Walnut St R4 470, Indianapolis, IN 46202, USA
    Blood 105:2783-6. 2005
    ..This study provides evidence that a diversity of EPCs exists in human vessels and provides a conceptual framework for determining both the origin and function of EPCs in maintaining vessel integrity...
  6. ncbi request reprint Identification of a novel hierarchy of endothelial progenitor cells using human peripheral and umbilical cord blood
    David A Ingram
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis 46202, USA
    Blood 104:2752-60. 2004
    ....
  7. pmc Pak1 regulates multiple c-Kit mediated Ras-MAPK gain-in-function phenotypes in Nf1+/- mast cells
    ANDREW S MCDANIEL
    Department of Microbiology and Immunology, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis 46202, USA
    Blood 112:4646-54. 2008
    ..Thus, Pak1 is a novel mast cell mediator that functions as a key node in the MAPK signaling network and potential therapeutic target in NF1 patients...
  8. doi request reprint Isolation and characterization of endothelial progenitor cells from human blood
    Laura E Mead
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Curr Protoc Stem Cell Biol . 2008
    ..In this unit, we describe detailed methodologies for isolation and characterization of ECFCs from both human peripheral and umbilical cord blood...
  9. pmc Nf1-dependent tumors require a microenvironment containing Nf1+/-- and c-kit-dependent bone marrow
    Feng Chun Yang
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Cell 135:437-48. 2008
    ..Further, genetic or pharmacologic attenuation of c-kit signaling in Nf1+/- hematopoietic cells diminishes neurofibroma initiation and progression. Finally, these studies implicate mast cells as critical mediators of tumor initiation...
  10. pmc Hyperactivation of p21ras and PI3K cooperate to alter murine and human neurofibromatosis type 1-haploinsufficient osteoclast functions
    Feng Chun Yang
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Clin Invest 116:2880-91. 2006
    ..Collectively, our results identify a what we believe to be a novel cellular and biochemical NF1-haploinsufficient phenotype in osteoclasts that has potential implications for the pathogenesis of NF1 bone disease...
  11. pmc Nf1+/- mast cells induce neurofibroma like phenotypes through secreted TGF-beta signaling
    Feng Chun Yang
    Department of Pediatrics, and Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 W Walnut Street, Indianapolis, IN 46202, USA
    Hum Mol Genet 15:2421-37. 2006
    ..Genetic or pharmacological inhibition of c-abl reverses fibroblast proliferation and collagen synthesis to wild-type levels. These studies identify a novel molecular target to inhibit neurofibroma formation...
  12. ncbi request reprint Neurofibroma-associated growth factors activate a distinct signaling network to alter the function of neurofibromin-deficient endothelial cells
    Amy M Munchhof
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 W Walnut Street, Indianapolis, IN 46202, USA
    Hum Mol Genet 15:1858-69. 2006
    ..Thus, these studies identify a unique biochemical pathway in Nf1+/- ECs as a potential therapeutic target in the neurofibroma microenvironment...
  13. pmc Suppressed hindlimb perfusion in Rac2-/- and Nox2-/- mice does not result from impaired collateral growth
    Matthew R Distasi
    Department of Cellular and Integrative Physiology, Indiana Univ School of Medicine, 1001 W 10th St, WD OPW 425 E, Indianapolis, IN 46202, USA
    Am J Physiol Heart Circ Physiol 296:H877-86. 2009
    ..These novel results indicate that collateral luminal expansion and intimal cell recruitment/proliferation are not mediated by Rac2 and Nox2...
  14. doi request reprint Ras dependent paracrine secretion of osteopontin by Nf1+/- osteoblasts promote osteoclast activation in a neurofibromatosis type I murine model
    Huijie Li
    Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Pediatr Res 65:613-8. 2009
    ..Our study identifies an important paracrine loop whereby elevated secretion of OPN by osteoblasts activate Nf1+/- OCLs that already have an intrinsic propensity for bone resorption leading to osteopenia and osteoporosis...
  15. pmc Application of polychromatic flow cytometry to identify novel subsets of circulating cells with angiogenic potential
    Myka L Estes
    Department of Pediatrics, Indiana University, Indianapolis, Indiana, USA
    Cytometry A 77:831-9. 2010
    ..In sum, a PFC protocol validated via in vitro and in vivo analyses, can be used to interrogate the roles of human hematopoietic elements in the growth and maintenance of the vasculature...
  16. pmc Nf1+/- mice have increased neointima formation via hyperactivation of a Gleevec sensitive molecular pathway
    Elisabeth A Lasater
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Hum Mol Genet 17:2336-44. 2008
    ....
  17. ncbi request reprint K-ras is critical for modulating multiple c-kit-mediated cellular functions in wild-type and Nf1+/- mast cells
    Waleed F Khalaf
    Department Microbiology and Immunology, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Immunol 178:2527-34. 2007
    ..These findings identify K-ras as a key effector in multiple mast cell functions and identify neurofibromin as a GAP for K-ras in mast cells...
  18. pmc Heterozygous inactivation of the Nf1 gene in myeloid cells enhances neointima formation via a rosuvastatin-sensitive cellular pathway
    Brian K Stansfield
    Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, IN 46202, USA
    Hum Mol Genet 22:977-88. 2013
    ..These studies identify neurofibromin-deficient myeloid cells as critical cellular effectors of Nf1(+/-) neointima formation and propose a potential therapeutic for NF1 cardiovascular disease...
  19. pmc Changes in the frequency and in vivo vessel-forming ability of rhesus monkey circulating endothelial colony-forming cells across the lifespan (birth to aged)
    W Chris Shelley
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Pediatr Res 71:156-61. 2012
    ....
  20. pmc Flow cytometric identification and functional characterization of immature and mature circulating endothelial cells
    Julie A Mund
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, 46202, USA
    Arterioscler Thromb Vasc Biol 32:1045-53. 2012
    ....
  21. ncbi request reprint Endothelial colony forming cells and mesenchymal stem cells are enriched at different gestational ages in human umbilical cord blood
    M Jawad Javed
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Pediatr Res 64:68-73. 2008
    ..These studies demonstrate that circulating MSCs and ECFCs appear at different GA in the human UCB, and that 24-28 wk GA UCB may be a novel source of MSCs for therapeutic use in human diseases...
  22. pmc A hierarchy of endothelial colony-forming cell activity displayed by bovine corneal endothelial cells
    Lan Huang
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Invest Ophthalmol Vis Sci 51:3943-9. 2010
    ..To test the hypothesis that the robust expansion of bovine corneal endothelial cells (BCECs) in vitro is due to the presence of individual endothelial cells with various levels of proliferative potential...
  23. pmc Genetic reduction of class IA PI-3 kinase activity alters fetal hematopoiesis and competitive repopulating ability of hematopoietic stem cells in vivo
    Laura S Haneline
    Indiana University School of Medicine, Herman B Wells Center for Pediatric Research, Indianapolis, IN 46202, USA
    Blood 107:1375-82. 2006
    ..Collectively, these data identify PI-3K as an important regulator of HSC function and potential therapeutic target in treating leukemic stem cells...
  24. pmc Rap1a is a key regulator of fibroblast growth factor 2-induced angiogenesis and together with Rap1b controls human endothelial cell functions
    Jingliang Yan
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Mol Cell Biol 28:5803-10. 2008
    ..These observations place Rap1 centrally in the human angiogenic process and suggest that both the Rap1a and Rap1b proteins are required for angiogenesis and that Rap1 is a critical mediator of FGF-induced ERK activation...
  25. pmc p21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics
    Jayme D Allen
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Blood 113:2695-705. 2009
    ..These data implicate Pak1 as an essential molecular target for modulating acute mast cell responses that contribute to allergic diseases...
  26. doi request reprint Robust functional vascular network formation in vivo by cooperation of adipose progenitor and endothelial cells
    Dmitry O Traktuev
    Indiana Center for Vascular Biology, Indiana University, School of Medicine, 975 W Walnut St, IB441, Indianapolis, IN 46202, USA
    Circ Res 104:1410-20. 2009
    ..Mixture of these 2 readily available, nontransformed human cell types provides a practical approach to tissue engineering, therapeutic revascularization, and in vivo studies of human vasculogenesis...
  27. pmc Loss of the nf1 tumor suppressor gene decreases fas antigen expression in myeloid cells
    Kelly Hiatt
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Am J Pathol 164:1471-9. 2004
    ..Thus, therapies designed to decrease p21(ras) activity and up-regulate Fas antigen expression may limit the pathological accumulation of myeloid cells in disease states where p21(ras) is hyperactivated...
  28. doi request reprint Endothelial progenitor cells and cardiovascular cell-based therapies
    Julie A Mund
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, 46202, USA
    Cytotherapy 11:103-13. 2009
    ....
  29. ncbi request reprint K-Ras is essential for normal fetal liver erythropoiesis
    Waleed F Khalaf
    Indiana University School of Medicine, Herman B Wells Center for Pediatric Research, 1044 W Walnut St R4 470, Indianapolis, IN 46202, USA
    Blood 105:3538-41. 2005
    ..Thus, these studies identify K-Ras as a unique Ras isoform that is essential for regulating fetal erythropoiesis in vivo...
  30. doi request reprint Identification of endothelial cells and progenitor cell subsets in human peripheral blood
    Myka L Estes
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Curr Protoc Cytom . 2010
    ..In sum, a reliable PFC protocol, which can be used to investigate the roles of human hematopoietic and endothelial elements in the growth and maintenance of the vasculature, is described...
  31. ncbi request reprint Neurofibromin is a novel regulator of RAS-induced signals in primary vascular smooth muscle cells
    Fang Li
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 W Walnut Street, Indianapolis, IN 46202, USA
    Hum Mol Genet 15:1921-30. 2006
    ....
  32. ncbi request reprint Human CD34+AC133+VEGFR-2+ cells are not endothelial progenitor cells but distinct, primitive hematopoietic progenitors
    Jamie Case
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Exp Hematol 35:1109-18. 2007
    ....
  33. ncbi request reprint Clonogenic endothelial progenitor cells are sensitive to oxidative stress
    David A Ingram
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indianapolis, Indiana 46202, USA
    Stem Cells 25:297-304. 2007
    ....
  34. pmc Bone marrow-derived angiogenic cells restore lung alveolar and vascular structure after neonatal hyperoxia in infant mice
    Vivek Balasubramaniam
    Pediatric Heart Lung Center, Department of Pediatrics, University of Colorado Denver, 12800 E 19th Ave, Aurora, CO 80045, USA
    Am J Physiol Lung Cell Mol Physiol 298:L315-23. 2010
    ..We conclude that treatment with BMDAC after neonatal hyperoxia restores lung structure in this model of bronchopulmonary dysplasia...
  35. doi request reprint Assessing identity, phenotype, and fate of endothelial progenitor cells
    Karen K Hirschi
    Department of Pediatrics, Center for Cell and Gene Therapy and Children s Nutrition Research Center, Baylor College of Medicine, Houston, TX 77030, USA
    Arterioscler Thromb Vasc Biol 28:1584-95. 2008
  36. ncbi request reprint Acute myocardial infarction in swine rapidly and selectively releases highly proliferative endothelial colony forming cells (ECFCs) into circulation
    Lan Huang
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Cell Transplant 16:887-97. 2007
    ..Because circulating ECFC are also altered in human subjects with severe coronary artery disease, the pig model of AMI may be an excellent preclinical model to test the role of ECFC in the pathophysiology of AMI...
  37. pmc Periostin is required for maturation and extracellular matrix stabilization of noncardiomyocyte lineages of the heart
    Paige Snider
    Cardiovascular Development Group, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, USA
    Circ Res 102:752-60. 2008
    ..Thus, peri(lacZ) knockouts provide a new model of viable latent valve disease...
  38. pmc p85alpha subunit of class IA PI-3 kinase is crucial for macrophage growth and migration
    Veerendra Munugalavadla
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Blood 106:103-9. 2005
    ....
  39. ncbi request reprint Polychromatic flow cytometry identifies novel subsets of circulating cells with angiogenic potential in pediatric solid tumors
    Kamnesh R Pradhan
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA
    Cytometry B Clin Cytom 80:335-8. 2011
    ....
  40. doi request reprint Endothelial abnormalities in adolescents with type 1 diabetes: a biomarker for vascular sequelae?
    Linda A DiMeglio
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202 5225, USA
    J Pediatr 157:540-6. 2010
    ....
  41. pmc Neurofibromin-deficient Schwann cells secrete a potent migratory stimulus for Nf1+/- mast cells
    Feng Chun Yang
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Clin Invest 112:1851-61. 2003
    ..Thus, these studies identify a novel interaction between Nf1-/- Schwann cells and Nf1+/- mast cells that is likely to be important in neurofibroma formation...
  42. doi request reprint Endothelial progenitor cell: ongoing controversy for defining these cells and their role in neoangiogenesis in the murine system
    Mervin C Yoder
    Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, IN 46202, USA
    Curr Opin Hematol 16:269-73. 2009
    ....
  43. pmc Ras-Mek-Erk signaling regulates Nf1 heterozygous neointima formation
    Brian K Stansfield
    Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana Department of Pediatrics and Neonatal Perinatal Medicine, Indiana University School of Medicine, Indianapolis, Indiana
    Am J Pathol 184:79-85. 2014
    ..These studies identify the Ras-Erk pathway in neurofibromin-deficient macrophages as the aberrant pathway responsible for enhanced neointima formation. ..
  44. doi request reprint Imatinib mesylate for plexiform neurofibromas in patients with neurofibromatosis type 1: a phase 2 trial
    Kent A Robertson
    Department of Pediatrics, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Lancet Oncol 13:1218-24. 2012
    ..We undertook an open-label phase 2 trial to test whether treatment with imatinib mesylate can decrease the volume burden of clinically significant plexiform neurofibromas in patients with NF1...
  45. ncbi request reprint Functional p85alpha gene is required for normal murine fetal erythropoiesis
    Hannah Huddleston
    Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 W Walnut St, R4 470, Indianapolis, IN 46202, USA
    Blood 102:142-5. 2003
    ..Taken together, these data establish an important role for p85alpha and class IA PI-3 kinase in regulating the development of both early and late erythroid progenitors in fetal liver...
  46. ncbi request reprint In vitro hyperglycemia or a diabetic intrauterine environment reduces neonatal endothelial colony-forming cell numbers and function
    David A Ingram
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Diabetes 57:724-31. 2008
    ..Therefore, our objectives were to determine whether hyperglycemia or exposure to a diabetic intrauterine environment alters EPC function...
  47. ncbi request reprint Suppression of hepatocyte growth factor production impairs the ability of adipose-derived stem cells to promote ischemic tissue revascularization
    Liying Cai
    Indiana Center for Vascular Biology and Medicine, Department of Cellular and Integrative Physiology, Indiana University School of Medicine, 975 W Walnut Street IB 441, Indianapolis, Indiana 46202, USA
    Stem Cells 25:3234-43. 2007
    ..This finding directly supports the emerging concept that local factor secretion by donor cells is a key element of cell-based therapies. Disclosure of potential conflicts of interest is found at the end of this article...
  48. ncbi request reprint Cord blood stem and progenitor cells
    Hal E Broxmeyer
    Department of Microbiology and Immunology, Medicine, and Pediatrics, Indiana University School of Medicine, Indianapolis, USA
    Methods Enzymol 419:439-73. 2006
    ....
  49. pmc Oxidative stress impairs endothelial progenitor cell function
    Jamie Case
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indianapolis, Indiana 46202, USA
    Antioxid Redox Signal 10:1895-907. 2008
    ....
  50. ncbi request reprint Unresolved questions, changing definitions, and novel paradigms for defining endothelial progenitor cells
    David A Ingram
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 W Walnut St, R4 402e, Indianapolis, IN 46202, USA
    Blood 106:1525-31. 2005
    ..The potential implications of this view in relation to current EPC definitions are discussed...
  51. pmc The definition of EPCs and other bone marrow cells contributing to neoangiogenesis and tumor growth: is there common ground for understanding the roles of numerous marrow-derived cells in the neoangiogenic process?
    Mervin C Yoder
    Biochemistry and Molecular Biology, Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA Pediatrics and of Biochemistry and Molecular Biology, Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA
    Biochim Biophys Acta 1796:50-4. 2009
    ....
  52. pmc Production of the endocannabinoids anandamide and 2-arachidonoylglycerol by endothelial progenitor cells
    Christiane A Opitz
    Krannert Institute of Cardiology, Indiana University School of Medicine, 1800 North Capitol Avenue, Room E310, Indianapolis, IN, United States
    FEBS Lett 581:4927-31. 2007
    ..Treatment of mature endothelial cells with endocannabinoids significantly reduced the induction of the pro-inflammatory adhesion molecule CD106 (VCAM-1) by TNF-alpha...
  53. pmc Gestational diabetes mellitus alters maternal and neonatal circulating endothelial progenitor cell subsets
    Juan C Acosta
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Am J Obstet Gynecol 204:254.e8-254.e15. 2011
    ..The purpose of this study was to examine whether women with gestational diabetes mellitus (GDM) and their offspring have reduced endothelial progenitor cell subsets and vascular reactivity...
  54. pmc Normal hematopoiesis and neurofibromin-deficient myeloproliferative disease require Erk
    Karl Staser
    Herman Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA
    J Clin Invest 123:329-34. 2013
    ....
  55. ncbi request reprint Differential mechanisms of x-ray-induced cell death in human endothelial progenitor cells isolated from cord blood and adults
    Marc S Mendonca
    Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Radiat Res 176:208-16. 2011
    ....
  56. ncbi request reprint Endothelial-monocyte-activating polypeptide II induces migration of endothelial progenitor cells via the chemokine receptor CXCR3
    Yonghao Hou
    Department of Cellular and Integrative Physiology and Indiana Center for Vascular Biology and Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Exp Hematol 34:1125-32. 2006
    ..Here we address the hypothesis that the hypoxia-inducible full-length endothelial-monocyte-activating polypeptide II (EMAP II) provides a mechanism to recruit late outgrowth highly proliferating endothelial progenitor cells (EPCs)...
  57. ncbi request reprint Lymphoproliferative defects in mice lacking the expression of neurofibromin: functional and biochemical consequences of Nf1 deficiency in T-cell development and function
    David A Ingram
    Section of Neonatal Perinatal Medicine, Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indianapolis, IN 46202, USA
    Blood 100:3656-62. 2002
    ..Collectively, these results identify neurofibromin as a GAP for Ras in T cells for maintaining immune homeostasis in vivo...

Research Grants1

  1. Ras-PI3K Pathway in Nf1-/-Hematopoiesis and Leukemia
    David Ingram; Fiscal Year: 2007
    ..abstract_text> ..