Thomas Imperiale

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. ncbi request reprint Results of screening colonoscopy among persons 40 to 49 years of age
    Thomas F Imperiale
    Division of Gastroenterology, Indiana University School of Medicine, Indianapolis, USA
    N Engl J Med 346:1781-5. 2002
  2. doi request reprint Noninvasive screening tests for colorectal cancer
    Thomas F Imperiale
    Indiana University School of Medicine, Regenstrief Institute, Inc and Richard L Roudebush VA Medical Center, Indianapolis, Indiana 46202, USA
    Dig Dis 30:16-26. 2012
  3. pmc Tailoring colorectal cancer screening by considering risk of advanced proximal neoplasia
    Thomas F Imperiale
    Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University, Indianapolis, IN 46202, USA
    Am J Med 125:1181-7. 2012
  4. pmc Second-look endoscopy for bleeding peptic ulcer disease: a decision-effectiveness and cost-effectiveness analysis
    Thomas F Imperiale
    Department of Medicine, Division of Gastroenterology, Indiana University School of Medicine, Indianapolis, IN, USA
    J Clin Gastroenterol 46:e71-5. 2012
  5. pmc Polyethylene glycol vs. sodium phosphate for bowel preparation: a treatment arm meta-analysis of randomized controlled trials
    Ravi Juluri
    Indiana University Health Physicians, Indianapolis, Indiana, USA
    BMC Gastroenterol 11:38. 2011
  6. doi request reprint Provider acceptance, safety, and effectiveness of a computer-based decision tool for colonoscopy preparation
    Thomas F Imperiale
    Center of Excellence for Implementation of Evidence based Research, Health Services Research and Development, Richard L Roudebush Veterans Affairs Medical Center, Indianapolis, IN, United States
    Int J Med Inform 80:726-33. 2011
  7. pmc Risk factors for advanced sporadic colorectal neoplasia in persons younger than age 50
    Thomas F Imperiale
    Division of Gastroenterology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, United States
    Cancer Detect Prev 32:33-8. 2008
  8. doi request reprint Variation in polyp detection rates at screening colonoscopy
    Thomas F Imperiale
    Division of Gastroenterology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Gastrointest Endosc 69:1288-95. 2009
  9. ncbi request reprint Fecal DNA versus fecal occult blood for colorectal-cancer screening in an average-risk population
    Thomas F Imperiale
    Department of Medicine, Indiana University, and the Regenstrief Institute, Indianapolis, IN 46202, USA
    N Engl J Med 351:2704-14. 2004
  10. doi request reprint A prospective randomized trial of 1 versus 2 injections during EUS-guided celiac plexus block for chronic pancreatitis pain
    Julia K LeBlanc
    Division of Gastroenterology and Hepatology, Indiana University Medical Center, Indianapolis, Indiana 46202, USA
    Gastrointest Endosc 69:835-42. 2009

Research Grants

  1. Using Risk to Tailor Management of Digestive Diseases
    Thomas Imperiale; Fiscal Year: 2007
  2. Quantifying Risk to Target Screening Colonoscopy
    Thomas Imperiale; Fiscal Year: 2009

Detail Information

Publications43

  1. ncbi request reprint Results of screening colonoscopy among persons 40 to 49 years of age
    Thomas F Imperiale
    Division of Gastroenterology, Indiana University School of Medicine, Indianapolis, USA
    N Engl J Med 346:1781-5. 2002
    ..The prevalence of colorectal lesions in persons 40 to 49 years of age, as identified on colonoscopy, has not been determined...
  2. doi request reprint Noninvasive screening tests for colorectal cancer
    Thomas F Imperiale
    Indiana University School of Medicine, Regenstrief Institute, Inc and Richard L Roudebush VA Medical Center, Indianapolis, Indiana 46202, USA
    Dig Dis 30:16-26. 2012
    ..Identifying an accurate, reliable, affordable, and acceptable noninvasive screening test for colorectal cancer (CRC) would greatly facilitate population screening...
  3. pmc Tailoring colorectal cancer screening by considering risk of advanced proximal neoplasia
    Thomas F Imperiale
    Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University, Indianapolis, IN 46202, USA
    Am J Med 125:1181-7. 2012
    ..Quantifying the risk of advanced proximal colorectal neoplasia might allow tailoring of colorectal cancer screening, with colonoscopy for those at high risk and less invasive screening for very low-risk persons...
  4. pmc Second-look endoscopy for bleeding peptic ulcer disease: a decision-effectiveness and cost-effectiveness analysis
    Thomas F Imperiale
    Department of Medicine, Division of Gastroenterology, Indiana University School of Medicine, Indianapolis, IN, USA
    J Clin Gastroenterol 46:e71-5. 2012
    ..Understanding conditions under which second-look endoscopy is beneficial might be useful for clinical decision making...
  5. pmc Polyethylene glycol vs. sodium phosphate for bowel preparation: a treatment arm meta-analysis of randomized controlled trials
    Ravi Juluri
    Indiana University Health Physicians, Indianapolis, Indiana, USA
    BMC Gastroenterol 11:38. 2011
    ..Results of meta-analyses of randomized trials comparing PEG and NaP are inconsistent and have not included trials comparing either or both preps to less traditional ones...
  6. doi request reprint Provider acceptance, safety, and effectiveness of a computer-based decision tool for colonoscopy preparation
    Thomas F Imperiale
    Center of Excellence for Implementation of Evidence based Research, Health Services Research and Development, Richard L Roudebush Veterans Affairs Medical Center, Indianapolis, IN, United States
    Int J Med Inform 80:726-33. 2011
    ....
  7. pmc Risk factors for advanced sporadic colorectal neoplasia in persons younger than age 50
    Thomas F Imperiale
    Division of Gastroenterology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, United States
    Cancer Detect Prev 32:33-8. 2008
    ..We sought to determine whether a retrospective case-control study could identify risk factors for sporadic CRC and advanced adenomatous polyps (together known as sporadic colorectal neoplasia [CRN])...
  8. doi request reprint Variation in polyp detection rates at screening colonoscopy
    Thomas F Imperiale
    Division of Gastroenterology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Gastrointest Endosc 69:1288-95. 2009
    ..Variation in polyp detection among endoscopists has been used to justify the need for establishing quality standards for colonoscopy performance...
  9. ncbi request reprint Fecal DNA versus fecal occult blood for colorectal-cancer screening in an average-risk population
    Thomas F Imperiale
    Department of Medicine, Indiana University, and the Regenstrief Institute, Indianapolis, IN 46202, USA
    N Engl J Med 351:2704-14. 2004
    ..We compared an approach that identifies abnormal DNA in stool samples with the Hemoccult II fecal occult-blood test in average-risk, asymptomatic persons 50 years of age or older...
  10. doi request reprint A prospective randomized trial of 1 versus 2 injections during EUS-guided celiac plexus block for chronic pancreatitis pain
    Julia K LeBlanc
    Division of Gastroenterology and Hepatology, Indiana University Medical Center, Indianapolis, Indiana 46202, USA
    Gastrointest Endosc 69:835-42. 2009
    ..The efficacy of 1-injection versus a 2-injections method of EUS-guided celiac plexus block (EUS-CPB) in patients with chronic pancreatitis is not known...
  11. doi request reprint Five-year risk of colorectal neoplasia after negative screening colonoscopy
    Thomas F Imperiale
    Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, USA
    N Engl J Med 359:1218-24. 2008
    ..The appropriate interval for endoscopic rescreening after a negative colonoscopic examination is uncertain...
  12. doi request reprint Effect of screening colonoscopy on colorectal cancer incidence and mortality
    Charles J Kahi
    Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Clin Gastroenterol Hepatol 7:770-5; quiz 711. 2009
    ..Colonoscopy is used widely for colorectal cancer (CRC) screening; however, its long-term impact on the incidence and mortality of CRC is not known...
  13. doi request reprint Tocolytic therapy: a meta-analysis and decision analysis
    David M Haas
    Department of Obstetrics and Gynecology, Division of Gastroenterology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Obstet Gynecol 113:585-94. 2009
    ..To determine the optimal first-line tocolytic agent for treatment of premature labor...
  14. doi request reprint Endoscopist-directed administration of propofol: a worldwide safety experience
    Douglas K Rex
    Division of Gastroenterology Hepatology, Indiana University Medical Center, Indianapolis, Indiana 46202, USA
    Gastroenterology 137:1229-37; quiz 1518-9. 2009
    ..Endoscopist-directed propofol sedation (EDP) remains controversial. We sought to update the safety experience of EDP and estimate the cost of using anesthesia specialists for endoscopic sedation...
  15. pmc Provider recommendations for colorectal cancer screening in elderly veterans
    Charles J Kahi
    Department of Medicine, Division of Gastroenterology and Hepatology, Indiana University School of Medicine, 1481 W 10th street C 7055, Indianapolis, IN 46202, USA
    J Gen Intern Med 24:1263-8. 2009
    ..We aimed to describe providers' experiences and practice patterns regarding screening for CRC in elderly patients in the VA system...
  16. doi request reprint High-definition chromocolonoscopy vs. high-definition white light colonoscopy for average-risk colorectal cancer screening
    Charles J Kahi
    Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Am J Gastroenterol 105:1301-7. 2010
    ..High-definition chromoscopy is used to increase the yield of colonoscopy for flat and depressed neoplasms; however, its role in average-risk patients undergoing routine screening remains uncertain...
  17. ncbi request reprint Do aspirin and nonsteroidal anti-inflammatory drugs cause false-positive fecal occult blood test results? A prospective study in a cohort of veterans
    Charles J Kahi
    Department of Medicine, Division of Gastroenterology and Hepatology, Indiana University Medical Center, Indianapolis, Indiana 46202, USA
    Am J Med 117:837-41. 2004
    ..To determine whether use of regular aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) is a risk factor for a false-positive fecal occult blood test result...
  18. doi request reprint Screening, surveillance, and primary prevention for colorectal cancer: a review of the recent literature
    Charles J Kahi
    Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Gastroenterology 135:380-99. 2008
  19. ncbi request reprint Aspirin and the prevention of colorectal cancer
    Thomas F Imperiale
    Indiana University School of Medicine, The Roudebush Veterans Affairs Medical Center, and the Regenstrief Institute, Indianapolis, USA
    N Engl J Med 348:879-80. 2003
  20. ncbi request reprint A randomized trial of yogurt for prevention of antibiotic-associated diarrhea
    Ripudaman S Beniwal
    Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Roudebush VA Medical Center, 11H 1481 W 10th Street, Indianapolis, Indiana 46202, USA
    Dig Dis Sci 48:2077-82. 2003
    ..02) between patients receiving and not receiving yogurt. For conclusion, dietary supplementation with yogurt is a simple, effective, and safe treatment that decreases the incidence and duration of AAD...
  21. ncbi request reprint Endoscopic ultrasound in non-small cell lung cancer and negative mediastinum on computed tomography
    Julia K LeBlanc
    Department of Medicine, Division of Gastroenterology, Pulmonology and Oncology, Indiana University Medical Center, Indianapolis, Indiana 46202, USA
    Am J Respir Crit Care Med 171:177-82. 2005
    ....
  22. ncbi request reprint Comparison of endoscopic ultrasonography and multidetector computed tomography for detecting and staging pancreatic cancer
    John DeWitt
    Department of Medicine, Division of Gastroenterology, Indiana University Medical Center, Roudebush Veterans Affairs Medical Center, and Regenstrief Institute, Inc, Indianapolis, Indiana 46202 5121, USA
    Ann Intern Med 141:753-63. 2004
    ..Accurate preoperative detection and staging of pancreatic cancer may identify patients with locoregional disease that is amenable to surgical resection...
  23. ncbi request reprint Endoscopic therapy versus medical therapy for bleeding peptic ulcer with adherent clot: a meta-analysis
    Charles J Kahi
    Indiana University Medical Center, and Roudebush Veterans Affairs Medical Center, Indianapolis, Indiana 46202, USA
    Gastroenterology 129:855-62. 2005
    ..The optimal management of bleeding peptic ulcer with adherent clot is controversial and may include endoscopic therapy or medical therapy...
  24. ncbi request reprint Using risk for advanced proximal colonic neoplasia to tailor endoscopic screening for colorectal cancer
    Thomas F Imperiale
    Indiana University School of Medicine, Indiana University, Roudebush Veterans Affairs Medical Center, Indianapolis, Indiana, USA
    Ann Intern Med 139:959-65. 2003
    ..Colonoscopic screening for colorectal cancer has been suggested because sigmoidoscopy misses nearly half of persons with advanced proximal neoplasia...
  25. doi request reprint Understanding differences in the guidelines for colorectal cancer screening
    Thomas F Imperiale
    Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Gastroenterology 138:1642-1647.e1. 2010
    ..In this issue of Gastroenterology, the editors present 2 expert perspectives on the colorectal screening guidelines published in the May 2008 issue of the journal...
  26. doi request reprint Real-time optical biopsy of colon polyps with narrow band imaging in community practice does not yet meet key thresholds for clinical decisions
    Uri Ladabaum
    Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California, USA
    Gastroenterology 144:81-91. 2013
    ..We prospectively evaluated real-time optical biopsy analysis of polyps with narrow band imaging (NBI) by community-based gastroenterologists...
  27. doi request reprint Continue or discontinue warfarin for fecal occult blood testing in 2010? Does the published evidence provide an answer?
    Thomas F Imperiale
    Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Am J Gastroenterol 105:2036-9. 2010
    ....
  28. ncbi request reprint Comparison of endoscopic ultrasound and computed tomography for the preoperative evaluation of pancreatic cancer: a systematic review
    John DeWitt
    Division of Gastroenterology, Department of Medicine, Indiana University Medical Center, Indianapolis, Indiana, USA
    Clin Gastroenterol Hepatol 4:717-25; quiz 664. 2006
    ..We therefore performed a systematic literature review to determine which test is more accurate...
  29. ncbi request reprint Is diverticulosis associated with colorectal neoplasia? A cross-sectional colonoscopic study
    Ben J Kieff
    Divisions of Gastroenterology, General Internal Medicine, and Biostatistics, Department of Medicine, School of Medicine, Indiana University, Indianapolis, IN 46202, USA
    Am J Gastroenterol 99:2007-11. 2004
    ..To determine the relationship between distal diverticulosis and risk for colorectal neoplasia...
  30. ncbi request reprint Predicting poor outcome from acute upper gastrointestinal hemorrhage
    Thomas F Imperiale
    Department of Medicine, Roudebush Veterans Affairs Medical Center, The Center of Excellence on Implementing Evidence Based Practice, Indiana University School of Medicine, Indianapolis 46202, USA
    Arch Intern Med 167:1291-6. 2007
    ..Uncertainty about the outcome of acute upper gastrointestinal bleeding often results in a longer-than-necessary hospital stay...
  31. pmc Is the distal hyperplastic polyp a marker for proximal neoplasia?
    Sachin Dave
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Ind, USA
    J Gen Intern Med 18:128-37. 2003
    ..The current literature is unclear about the association between distal hyperplastic polyps and synchronous neoplasia (adenomatous polyps and cancer) in the proximal colon...
  32. doi request reprint Nurse-administered propofol sedation for upper endoscopic ultrasonography
    Hala Fatima
    Division of Gastroenterology, Department of Medicine, Indiana University Medical Center, Indianapolis, Indiana 46202 5121, USA
    Am J Gastroenterol 103:1649-56. 2008
    ..Limited data exist regarding the safety of nurse-administered propofol sedation (NAPS) for advanced endoscopy...
  33. ncbi request reprint Cost-effectiveness analysis of variceal ligation vs. beta-blockers for primary prevention of variceal bleeding
    Thomas F Imperiale
    Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Hepatology 45:870-8. 2007
    ..If only LYs are considered, then EVL is not cost-effective compared to BB therapy; however, if QoL is considered, then EVL is cost-effective...
  34. ncbi request reprint Measuring the hemodynamic response to primary pharmacoprophylaxis of variceal bleeding: a cost-effectiveness analysis
    Thomas F Imperiale
    Division of Gastroenterology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Am J Gastroenterol 98:2742-50. 2003
    ..The aim of this study was to compare HDM with no HDM in patients considered for primary pharmacoprophylaxis of esophageal variceal bleeding...
  35. ncbi request reprint Toward risk stratification for screening and surveillance of colorectal neoplasia: one small step for the colonoscopist
    Thomas F Imperiale
    Gastroenterology 133:1364-7. 2007
  36. ncbi request reprint Guidelines for surveillance intervals after polypectomy: coping with the evidence
    Thomas F Imperiale
    Ann Intern Med 148:477-9. 2008
  37. ncbi request reprint Survival of elderly persons undergoing colonoscopy: implications for colorectal cancer screening and surveillance
    Charles J Kahi
    Indiana University Medical Center, Roudebush Veterans Affairs Medical Center, Indiana University Department of Biostatistics, Indianapolis, Indiana 46202, USA
    Gastrointest Endosc 66:544-50. 2007
    ..In the elderly, the increased prevalence of colorectal neoplasia and the protective effect of colonoscopy may be offset by advancing age and comorbidity...
  38. ncbi request reprint Quantitative immunochemical fecal occult blood tests: is it time to go back to the future?
    Thomas F Imperiale
    Ann Intern Med 146:309-11. 2007
  39. ncbi request reprint Comparison of a brush-sampling fecal immunochemical test for hemoglobin with a sensitive guaiac-based fecal occult blood test in detection of colorectal neoplasia
    Robert H Fletcher
    Cancer 109:1925-6; author reply 1926. 2007
  40. ncbi request reprint Elevated prevalence of hepatitis C infection in users of United States veterans medical centers
    Jason A Dominitz
    Epidemiologic Research and Information Center VA Puget Sound Health Care System, Seattle, WA 98108 1597, USA
    Hepatology 41:88-96. 2005
    ..In conclusion, the prevalence of hepatitis C in these subjects exceeds the estimate from the general US population by more than 2-fold, likely reflecting more exposure to traditional risk factors among these veterans...
  41. ncbi request reprint Can computed tomographic colonography become a "good" screening test?
    Thomas F Imperiale
    Ann Intern Med 142:669-70. 2005
  42. doi request reprint CT colonography versus colonoscopy for the detection of advanced neoplasia
    Douglas K Rex
    N Engl J Med 358:88; author reply 90. 2008
  43. ncbi request reprint Impact of bowel preparation on efficiency and cost of colonoscopy
    Douglas K Rex
    Indiana University Medical Center, Roudebush VA Medical Center, Regenstrief Institute for Health Care, Indianapolis, USA
    Am J Gastroenterol 97:1696-700. 2002
    ..The impact of bowel preparation on the cost and efficiency of colonoscopy is uncertain. The aim of this study was to measure the impact of bowel preparation on total direct cost as well as procedure time and volume...

Research Grants7

  1. Using Risk to Tailor Management of Digestive Diseases
    Thomas Imperiale; Fiscal Year: 2007
    ..abstract_text> ..
  2. Quantifying Risk to Target Screening Colonoscopy
    Thomas Imperiale; Fiscal Year: 2009
    ..The knowledge generated by this research will help maximize prevention and minimize the morbidity and cost of CRC screening. ..