Genomes and Genes
Affiliation: Indiana University
- PLAB, a novel placental bone morphogenetic proteinR Hromas
Department of Medicine and the Walther Oncology Center, Indiana University Medical Center, Indianapolis 46202, USA
Biochim Biophys Acta 1354:40-4. 1997..Like TGF-beta, PLAB inhibits the proliferation of primitive hematopoietic progenitors. The high expression of PLAB by placenta raises the possibility that it may be a mediator of placental control of embryonic development...
- Effects of CC, CXC, C, and CX3C chemokines on proliferation of myeloid progenitor cells, and insights into SDF-1-induced chemotaxis of progenitorsH E Broxmeyer
Department of Microbiology, Indiana University School of Medicine, Indianapolis 46202, USA
Ann N Y Acad Sci 872:142-62; discussion 163. 1999..It was also found that SDF-1-induced chemotaxis of progenitors can occur in the presence of fibronectin (FN) and extracellular matrix components and that FN effects involve activation of beta 1-, and possibly alpha 4-, integrins...
- Forced expression of Genesis, a winged helix transcriptional repressor isolated from embryonic stem cells, blocks granulocytic differentiation of 32D myeloid cellsD Xu
Division of Hematology Oncology and the Walther Oncology Center, Indiana University Medical Center, Indianapolis 46202 5121, USA
Leukemia 12:207-12. 1998..This finding implicates Genesis in the regulation of development, and also implies that there may be common transcription pathways for many developing tissues...
- Isolation and characterization of Exodus-2, a novel C-C chemokine with a unique 37-amino acid carboxyl-terminal extensionR Hromas
Department of Medicine, Indiana University Medical Center, Indianapolis 46202, USA
J Immunol 159:2554-8. 1997..The combination of these characteristics may be a functional correlate for the unique carboxyl-terminal structure of Exodus-2...
- The exodus subfamily of CC chemokines inhibits the proliferation of chronic myelogenous leukemia progenitorsR Hromas
Hematology Oncology, Biochemistry Molecular Biology, Microbiology Immunology, and the Walther Oncology Center, Indiana University Medical Center, Indianapolis, Indiana 46202, USA
Blood 95:1506-8. 2000..This demonstration of consistent inhibition of CML progenitor proliferation makes the 3 Exodus chemokines unique among chemokines. (Blood. 2000;95:1506-1508)..
- Genesis, a Winged Helix transcriptional repressor, has embryonic expression limited to the neural crest, and stimulates proliferation in vitro in a neural development modelR Hromas
Division of Hematology Oncology and the Walther Oncology Center, IB 442, Indiana University Medical Center, 975 W Walnut St, Indianapolis, IN 46202 5121, USA
Cell Tissue Res 297:371-82. 1999..These data also lend evidence for the hypothesis that proliferation and differentiation pathways are not irrevocably linked, but can function independently...
- Isolation of ALP, a novel divergent murine CC chemokine with a unique carboxy terminal extensionR Hromas
Hematology Oncology, Biochemistry Molecular Biology, and the Walther Oncology Center, Indiana University Medical Center, 1044 W Walnut St, Indianapolis, Indiana, 46202, USA
Biochem Biophys Res Commun 258:737-40. 1999..It is expressed preferentially in testis, heart, and liver, which is atypical for CC chemokines...
- Cutting edge: IL-17F, a novel cytokine selectively expressed in activated T cells and monocytes, regulates angiogenesis and endothelial cell cytokine productionT Starnes
Department of Medicine and Biochemistry, Walther Oncology Center, Indiana University Medical Center, Indianapolis, IN 46202, USA
J Immunol 167:4137-40. 2001..However, it markedly inhibited the angiogenesis of human endothelial cells and induced endothelial cells to produce IL-2, TGF-beta, and monocyte chemoattractant protein-1...
- A positive effect of p21cip1/waf1 in the colony formation from murine myeloid progenitor cells as assessed by retroviral-mediated gene transferS E Braun
Department of Microbiology Immunology, Indiana University School of Medicine, Indianapolis 46202, USA
Blood Cells Mol Dis 24:138-48. 1998..These results document the positive effect of p21cip1/waf1 in the proliferation and/or differentiation of the murine myeloid progenitor cells that lead to colony formation...
- Cloning and characterization of exodus, a novel beta-chemokineR Hromas
Department of Hematology Oncology and the Walther Oncology Center, Indiana University Medical Center, Indianapolis 46202, USA
Blood 89:3315-22. 1997..Exodus also stimulated chemotaxis of peripheral blood mononuclear cells. The sequence homology, expression, and biological activity indicate that Exodus represents a novel divergent beta-chemokine...
- Genesis, a winged helix transcriptional repressor with expression restricted to embryonic stem cellsJ Sutton
Division of Hematology Oncology and the Walther Oncology Center, IB 442, Indiana University Medical Center, Indianapolis, Indiana 46202 5121, USA
J Biol Chem 271:23126-33. 1996..Genesis is a candidate for regulating the phenotype of normal or malignant embryonic stem cells...
- Drosophila forkhead homologues are expressed in a lineage-restricted manner in human hematopoietic cellsR Hromas
Department of Hematology Oncology, Indiana University Medical Center, Indianapolis 46202 5121
Blood 81:2854-9. 1993..The H3 and 5-3 clones provide evidence that FKH family members are present in a tissue-restricted manner in humans...
- Cloning of BRAK, a novel divergent CXC chemokine preferentially expressed in normal versus malignant cellsR Hromas
Department of Hematology and Oncology, Walther Oncology Center, Indiana University Medical Center, R4 202, 1044 W Walnut Street, Indianapolis, Indiana, 46202
Biochem Biophys Res Commun 255:703-6. 1999..BRAK is expressed ubiquitously and highly in normal tissue. However, it was expressed in only 2 of 18 cancer cell lines. BRAK is located on human chromosome 5q31...
- The HEM proteins: a novel family of tissue-specific transmembrane proteins expressed from invertebrates through mammals with an essential function in oogenesisS Baumgartner
Friedrich Miescher Institute, Basel, Switerzland
J Mol Biol 251:41-9. 1995..Of the vertebrate HEM family members, the mammalian Hem-1 gene is expressed only in cells of hematopoietic origin, while Hem-2 is preferentially expressed in brain, heart, liver and testis...
- PCR cloning of an orphan homeobox gene (PRH) preferentially expressed in myeloid and liver cellsR Hromas
Walther Oncology Center, Indiana University Medical Center, Indianapolis 46202
Biochem Biophys Res Commun 195:976-83. 1993..The structure, chromosomal location, and pattern of expression of PRH indicate that it represents an orphan homeobox gene that may regulate the lineage development of certain hematopoietic cells...
- PE-1, a novel ETS oncogene family member, localizes to chromosome 1q21-q23M Klemsz
Department of Microbiology Immunology, Indiana University Medical Center, Indianapolis 46202
Genomics 20:291-4. 1994..8-kb transcript observed. PE-1 was the most common ETS domain gene found in CD34+HLA-DR- hematopoietic progenitors. PE-1 was localized to human chromosome 1q21-q23 using both in situ chromosomal hybridization and human-hamster hybrids...
- Chemokine regulation of normal and pathologic immune responsesK Christopherson
Indiana University Cancer Center and the Walther Oncology Institute, Indianapolis, Indiana 46202, USA
Stem Cells 19:388-96. 2001..Therefore, it is likely that chemokines will become important targets for pharmacologic intervention in a wide variety of human diseases in the future...
- Fusion AML1 transcript in a radiation-associated leukemia results in a truncated inhibitory AML1 proteinR Hromas
Indiana University Cancer Center, Indianapolis, Indiana 46202, USA
Blood 97:2168-70. 2001..This fusion AML1 protein functions as an inhibitor of the normal AML1 protein. (Blood. 2001;97:2168-2170)..
- Hematopoietic lineage- and stage-restricted expression of the ETS oncogene family member PU.1R Hromas
Department of Medicine, Walther Oncology Center, Indiana University Medical Center, Indianapolis 46252 5121
Blood 82:2998-3004. 1993..Thus, its expression pattern makes PU.1 a candidate for a genetic determinant of lineage commitment and stage progression in blood cell development. It also lends insight into how PU.1 might play a role in Friend virus erythroleukemia...
- The Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1W A May
Department of Pediatrics, Gwynne Hazen Cherry Memorial Laboratories, University of California, Los Angeles
Mol Cell Biol 13:7393-8. 1993..EWS/FLI-1 could disrupt normal growth and differentiation either by more efficiently activating FLI-1 target genes or by inappropriately modulating genes normally not responsive to FLI-1...
- Human FLI-1 localizes to chromosome 11Q24 and has an aberrant transcript in neuroepitheliomaR Hromas
Department of Medicine, Indiana University Medical Center, Indianapolis 46202
Biochim Biophys Acta 1172:155-8. 1993..In the neuroepithelioma cell line TC-32 the FLI-1 transcript is present but has an aberrant structure, indicating that it may be rearranged in neuroepithelioma...
- Hem-1, a potential membrane protein, with expression restricted to blood cellsR Hromas
Department of Medicine IB 442, Indiana University Medical Center, Indianapolis 46202 5121
Biochim Biophys Acta 1090:241-4. 1991..The gene is located at 12q13.1, a region of occasional translocations in hematopoietic neoplasia and a rare folic acid fragile site, Fra 12A...