R Hromas

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. ncbi request reprint A novel syndrome of radiation-associated acute myeloid leukemia involving AML1 gene translocations
    R Hromas
    Indiana University Cancer Center, Indianapolis, IN 46202, USA
    Blood 95:4011-3. 2000
  2. ncbi request reprint The exodus subfamily of CC chemokines inhibits the proliferation of chronic myelogenous leukemia progenitors
    R Hromas
    Hematology Oncology, Biochemistry Molecular Biology, Microbiology Immunology, and the Walther Oncology Center, Indiana University Medical Center, Indianapolis, Indiana 46202, USA
    Blood 95:1506-8. 2000
  3. ncbi request reprint Genesis, a Winged Helix transcriptional repressor, has embryonic expression limited to the neural crest, and stimulates proliferation in vitro in a neural development model
    R Hromas
    Division of Hematology Oncology and the Walther Oncology Center, IB 442, Indiana University Medical Center, 975 W Walnut St, Indianapolis, IN 46202 5121, USA
    Cell Tissue Res 297:371-82. 1999
  4. ncbi request reprint Isolation of ALP, a novel divergent murine CC chemokine with a unique carboxy terminal extension
    R Hromas
    Hematology Oncology, Biochemistry Molecular Biology, and the Walther Oncology Center, Indiana University Medical Center, 1044 W Walnut St, Indianapolis, Indiana, 46202, USA
    Biochem Biophys Res Commun 258:737-40. 1999
  5. ncbi request reprint The chemokine CCL21 protects normal marrow progenitors from Ara-C cytotoxicity
    Robert Hromas
    Hematology Oncology, Biochemistry Molecular Biology, and the Walther Oncology Center, Indiana University Medical Center, R4 202, 1044 W Walnut St, Indianapolis, IN 46202, USA
    Cancer Chemother Pharmacol 50:163-6. 2002
  6. ncbi request reprint Fusion AML1 transcript in a radiation-associated leukemia results in a truncated inhibitory AML1 protein
    R Hromas
    Indiana University Cancer Center, Indianapolis, Indiana 46202, USA
    Blood 97:2168-70. 2001
  7. ncbi request reprint Isolation and characterization of Exodus-2, a novel C-C chemokine with a unique 37-amino acid carboxyl-terminal extension
    R Hromas
    Department of Medicine, Indiana University Medical Center, Indianapolis 46202, USA
    J Immunol 159:2554-8. 1997
  8. ncbi request reprint Forced expression of Genesis, a winged helix transcriptional repressor isolated from embryonic stem cells, blocks granulocytic differentiation of 32D myeloid cells
    D Xu
    Division of Hematology Oncology and the Walther Oncology Center, Indiana University Medical Center, Indianapolis 46202 5121, USA
    Leukemia 12:207-12. 1998
  9. ncbi request reprint Cloning of BRAK, a novel divergent CXC chemokine preferentially expressed in normal versus malignant cells
    R Hromas
    Department of Hematology and Oncology, Walther Oncology Center, Indiana University Medical Center, R4 202, 1044 W Walnut Street, Indianapolis, Indiana, 46202
    Biochem Biophys Res Commun 255:703-6. 1999
  10. ncbi request reprint Cloning and characterization of exodus, a novel beta-chemokine
    R Hromas
    Department of Hematology Oncology and the Walther Oncology Center, Indiana University Medical Center, Indianapolis 46202, USA
    Blood 89:3315-22. 1997

Collaborators

Detail Information

Publications28

  1. ncbi request reprint A novel syndrome of radiation-associated acute myeloid leukemia involving AML1 gene translocations
    R Hromas
    Indiana University Cancer Center, Indianapolis, IN 46202, USA
    Blood 95:4011-3. 2000
    ..Two of these AML1 translocations, the t(18;21) and the t(19;21), have not been reported previously. It is possible that the AML1 gene is a target for radiation-induced AML. (Blood. 2000;95:4011-4013)..
  2. ncbi request reprint The exodus subfamily of CC chemokines inhibits the proliferation of chronic myelogenous leukemia progenitors
    R Hromas
    Hematology Oncology, Biochemistry Molecular Biology, Microbiology Immunology, and the Walther Oncology Center, Indiana University Medical Center, Indianapolis, Indiana 46202, USA
    Blood 95:1506-8. 2000
    ..This demonstration of consistent inhibition of CML progenitor proliferation makes the 3 Exodus chemokines unique among chemokines. (Blood. 2000;95:1506-1508)..
  3. ncbi request reprint Genesis, a Winged Helix transcriptional repressor, has embryonic expression limited to the neural crest, and stimulates proliferation in vitro in a neural development model
    R Hromas
    Division of Hematology Oncology and the Walther Oncology Center, IB 442, Indiana University Medical Center, 975 W Walnut St, Indianapolis, IN 46202 5121, USA
    Cell Tissue Res 297:371-82. 1999
    ..These data also lend evidence for the hypothesis that proliferation and differentiation pathways are not irrevocably linked, but can function independently...
  4. ncbi request reprint Isolation of ALP, a novel divergent murine CC chemokine with a unique carboxy terminal extension
    R Hromas
    Hematology Oncology, Biochemistry Molecular Biology, and the Walther Oncology Center, Indiana University Medical Center, 1044 W Walnut St, Indianapolis, Indiana, 46202, USA
    Biochem Biophys Res Commun 258:737-40. 1999
    ..It is expressed preferentially in testis, heart, and liver, which is atypical for CC chemokines...
  5. ncbi request reprint The chemokine CCL21 protects normal marrow progenitors from Ara-C cytotoxicity
    Robert Hromas
    Hematology Oncology, Biochemistry Molecular Biology, and the Walther Oncology Center, Indiana University Medical Center, R4 202, 1044 W Walnut St, Indianapolis, IN 46202, USA
    Cancer Chemother Pharmacol 50:163-6. 2002
    ..In this study we sought to determine whether this inhibition of proliferation could be therapeutically exploited by protecting normal marrow progenitors from the cytotoxicity of the S phase-active chemotherapeutic agent Ara-C...
  6. ncbi request reprint Fusion AML1 transcript in a radiation-associated leukemia results in a truncated inhibitory AML1 protein
    R Hromas
    Indiana University Cancer Center, Indianapolis, Indiana 46202, USA
    Blood 97:2168-70. 2001
    ..This fusion AML1 protein functions as an inhibitor of the normal AML1 protein. (Blood. 2001;97:2168-2170)..
  7. ncbi request reprint Isolation and characterization of Exodus-2, a novel C-C chemokine with a unique 37-amino acid carboxyl-terminal extension
    R Hromas
    Department of Medicine, Indiana University Medical Center, Indianapolis 46202, USA
    J Immunol 159:2554-8. 1997
    ..The combination of these characteristics may be a functional correlate for the unique carboxyl-terminal structure of Exodus-2...
  8. ncbi request reprint Forced expression of Genesis, a winged helix transcriptional repressor isolated from embryonic stem cells, blocks granulocytic differentiation of 32D myeloid cells
    D Xu
    Division of Hematology Oncology and the Walther Oncology Center, Indiana University Medical Center, Indianapolis 46202 5121, USA
    Leukemia 12:207-12. 1998
    ..This finding implicates Genesis in the regulation of development, and also implies that there may be common transcription pathways for many developing tissues...
  9. ncbi request reprint Cloning of BRAK, a novel divergent CXC chemokine preferentially expressed in normal versus malignant cells
    R Hromas
    Department of Hematology and Oncology, Walther Oncology Center, Indiana University Medical Center, R4 202, 1044 W Walnut Street, Indianapolis, Indiana, 46202
    Biochem Biophys Res Commun 255:703-6. 1999
    ..BRAK is expressed ubiquitously and highly in normal tissue. However, it was expressed in only 2 of 18 cancer cell lines. BRAK is located on human chromosome 5q31...
  10. ncbi request reprint Cloning and characterization of exodus, a novel beta-chemokine
    R Hromas
    Department of Hematology Oncology and the Walther Oncology Center, Indiana University Medical Center, Indianapolis 46202, USA
    Blood 89:3315-22. 1997
    ..Exodus also stimulated chemotaxis of peripheral blood mononuclear cells. The sequence homology, expression, and biological activity indicate that Exodus represents a novel divergent beta-chemokine...
  11. ncbi request reprint Regulation of human natural killer cell migration and proliferation by the exodus subfamily of CC chemokines
    M J Robertson
    Bone Marrow Transplantation Program and Division of Hematology Oncology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Cell Immunol 199:8-14. 2000
    ..Exodus-2 and -3 may regulate interactions between T cells and NK cells that are crucial for the generation of optimal immune responses...
  12. ncbi request reprint Cutting edge: IL-17F, a novel cytokine selectively expressed in activated T cells and monocytes, regulates angiogenesis and endothelial cell cytokine production
    T Starnes
    Department of Medicine and Biochemistry, Walther Oncology Center, Indiana University Medical Center, Indianapolis, IN 46202, USA
    J Immunol 167:4137-40. 2001
    ..However, it markedly inhibited the angiogenesis of human endothelial cells and induced endothelial cells to produce IL-2, TGF-beta, and monocyte chemoattractant protein-1...
  13. pmc Functional characterization of the C---C chemokine-like molecules encoded by molluscum contagiosum virus types 1 and 2
    M D Krathwohl
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Proc Natl Acad Sci U S A 94:9875-80. 1997
    ..The significance of hematopoietic progenitor cell inhibition in viral pathogenesis is uncertain...
  14. ncbi request reprint Chemokine regulation of normal and pathologic immune responses
    K Christopherson
    Indiana University Cancer Center and the Walther Oncology Institute, Indianapolis, Indiana 46202, USA
    Stem Cells 19:388-96. 2001
    ..Therefore, it is likely that chemokines will become important targets for pharmacologic intervention in a wide variety of human diseases in the future...
  15. ncbi request reprint Genesis, a winged helix transcriptional repressor with expression restricted to embryonic stem cells
    J Sutton
    Division of Hematology Oncology and the Walther Oncology Center, IB 442, Indiana University Medical Center, Indianapolis, Indiana 46202 5121, USA
    J Biol Chem 271:23126-33. 1996
    ..Genesis is a candidate for regulating the phenotype of normal or malignant embryonic stem cells...
  16. ncbi request reprint The CC chemokine CK beta-11/MIP-3 beta/ELC/Exodus 3 mediates tumor rejection of murine breast cancer cells through NK cells
    S E Braun
    Departments ofMicrobiology Immunology and Medicine Hematology Oncology, and Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Immunol 164:4025-31. 2000
    ..Furthermore, CK beta-11-transduced tumor cells generate long-term antitumor immunity that requires CD4+ cells. These studies demonstrate the potential role of CK beta-11 as an adjuvant in stimulating antitumor responses...
  17. ncbi request reprint PLAB, a novel placental bone morphogenetic protein
    R Hromas
    Department of Medicine and the Walther Oncology Center, Indiana University Medical Center, Indianapolis 46202, USA
    Biochim Biophys Acta 1354:40-4. 1997
    ..Like TGF-beta, PLAB inhibits the proliferation of primitive hematopoietic progenitors. The high expression of PLAB by placenta raises the possibility that it may be a mediator of placental control of embryonic development...
  18. ncbi request reprint Effects of CC, CXC, C, and CX3C chemokines on proliferation of myeloid progenitor cells, and insights into SDF-1-induced chemotaxis of progenitors
    H E Broxmeyer
    Department of Microbiology, Indiana University School of Medicine, Indianapolis 46202, USA
    Ann N Y Acad Sci 872:142-62; discussion 163. 1999
    ..It was also found that SDF-1-induced chemotaxis of progenitors can occur in the presence of fibronectin (FN) and extracellular matrix components and that FN effects involve activation of beta 1-, and possibly alpha 4-, integrins...
  19. ncbi request reprint A positive effect of p21cip1/waf1 in the colony formation from murine myeloid progenitor cells as assessed by retroviral-mediated gene transfer
    S E Braun
    Department of Microbiology Immunology, Indiana University School of Medicine, Indianapolis 46202, USA
    Blood Cells Mol Dis 24:138-48. 1998
    ..These results document the positive effect of p21cip1/waf1 in the proliferation and/or differentiation of the murine myeloid progenitor cells that lead to colony formation...
  20. doi request reprint Long-term disease-free survival after nonmyeloablative cyclophosphamide/fludarabine conditioning and related/unrelated allotransplantation for acute myeloid leukemia/myelodysplasia
    R P Nelson
    Division of Hematology Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202 5289, USA
    Bone Marrow Transplant 45:1300-8. 2010
    ..This study provides further evidence for prolonged DFS after CY/Flu MRD allotransplantation for AML/MDS, and extends the findings to older patients and those with unrelated donors...
  21. ncbi request reprint Endothelial induction of the T-cell chemokine CCL21 in T-cell autoimmune diseases
    Kent W Christopherson
    Department of Microbiology and Immunology and the Walther Oncology Center, Indiana University Medical Center, Indianapolis 46202, USA
    Blood 101:801-6. 2003
    ..These data imply that the usual loss of CCL21 responsiveness in the normal development of memory T-cell effector function does not hold for autoimmune skin diseases...
  22. ncbi request reprint AML1-FOG2 fusion protein in myelodysplasia
    Edward M Chan
    Division of Hematology Oncology, Department of Medicine, Indiana University School of Medicine, 1044 W Walnut St, R4 202, Indianapolis, IN 46202 5254, USA
    Blood 105:4523-6. 2005
    ..These results suggest a central role for CtBP in AML1-FOG2 transcriptional repression and implicate coordinated disruption of the AML1 and GATAdevelopmental programs in the pathogenesis of myelodysplasia...
  23. pmc Biochemical characterization of a SET and transposase fusion protein, Metnase: its DNA binding and DNA cleavage activity
    Yaritzabel Roman
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Biochemistry 46:11369-76. 2007
    ..Together, our results suggest that Metnase's DNA cleavage activity, unlike those of other eukaryotic transposases, is not coupled to its sequence-specific DNA binding...
  24. ncbi request reprint Evolution of the cutaneous immune response to experimental Haemophilus ducreyi infection and its relevance to HIV-1 acquisition
    Tricia L Humphreys
    Department of Medicine, Indiana University, Indianapolis 46202, USA
    J Immunol 169:6316-23. 2002
    ..ducreyi-infected lesions may provide an environment that facilitates the acquisition of R5 (CCR5), X4 (CXCR4), and dual-tropic HIV-1 strains...
  25. ncbi request reprint Low-molecular-weight heparins inhibit CCL21-induced T cell adhesion and migration
    Kent W Christopherson
    Department of Biochemistry Molecular Biology, Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Pharmacol Exp Ther 302:290-5. 2002
    ..Therefore, low-molecular-weight heparins may be effective therapeutic agents in decreasing the pathology of T cell-infiltrative autoimmune diseases by targeting the CCL21 regulation of T cell infiltration...
  26. ncbi request reprint Update on late relapse of germ cell tumor: a clinical and molecular analysis
    David W George
    Department of Medicine, and Section of Hematology Oncology, Herman B Wells Center for Pediatric Research, Indiana University Medical Center, Indianapolis, IN, USA
    J Clin Oncol 21:113-22. 2003
    ..Analysis of patients with late relapse (LR) of germ cell tumor (GCT) with reports on clinical characteristics, outcomes, and molecular and cytogenetic features...
  27. pmc Oct-4 is critical for survival/antiapoptosis of murine embryonic stem cells subjected to stress: effects associated with Stat3/survivin
    Ying Guo
    Department of Microbiology and Immunology and the Walther Oncology Center, Indiana University School of Medicine, Indianapolis, Indiana 46202 5181, USA
    Stem Cells 26:30-4. 2008
    ..Our results suggest that Oct-4 is essential for antiapoptosis of ES cells in response to stress, effects that may be mediated through the STAT3/Survivin pathway...
  28. pmc Human Pso4 is a metnase (SETMAR)-binding partner that regulates metnase function in DNA repair
    Brian D Beck
    Department of Biochemistry and Molecular Biology and the Walther Cancer Institute, Indiana University School of Medicine, 1044 W Walnut Street, Indianapolis, IN 46202, USA
    J Biol Chem 283:9023-30. 2008
    ....