Brittney Shea Herbert

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. ncbi request reprint p16(INK4a) inactivation is not required to immortalize human mammary epithelial cells
    Brittney Shea Herbert
    Department of Cell Biology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas, TX 75390 9039, USA
    Oncogene 21:7897-900. 2002
  2. ncbi request reprint Telomere dysfunction in aging and cancer
    David Gilley
    Department of Medical and Molecular Genetics, The Indiana University Cancer Center, Indiana University School of Medicine, 975 West Walnut St, IB 242, Indianapolis, IN 46202 5251, USA
    Int J Biochem Cell Biol 37:1000-13. 2005
  3. ncbi request reprint Nonradioactive detection of telomerase activity using the telomeric repeat amplification protocol
    Brittney Shea Herbert
    Department of Medical and Molecular Genetics, Indiana University Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana 46202 5251, USA
    Nat Protoc 1:1583-90. 2006
  4. pmc A molecular signature of normal breast epithelial and stromal cells from Li-Fraumeni syndrome mutation carriers
    Brittney Shea Herbert
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA
    Oncotarget 1:405-22. 2010
  5. ncbi request reprint Meeting report: second international meeting on quadruplex DNA
    Brittney Shea Herbert
    Dept of Medical and Molecular Genetics, Indiana University Melvin and Bren Simon Cancer Center, Indiana University Center for Regenerative Biology and Medicine, Indiana University School of Medicine, IB 242 Indianapolis, IN 46202, USA
    Biochimie 91:1059-65. 2009
  6. ncbi request reprint Lipid modification of GRN163, an N3'-->P5' thio-phosphoramidate oligonucleotide, enhances the potency of telomerase inhibition
    Brittney Shea Herbert
    Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9039, USA
    Oncogene 24:5262-8. 2005
  7. ncbi request reprint Telomerase template antagonist GRN163L disrupts telomere maintenance, tumor growth, and metastasis of breast cancer
    Amelia E Hochreiter
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202 5251, USA
    Clin Cancer Res 12:3184-92. 2006
  8. ncbi request reprint Specific telomere dysfunction induced by GRN163L increases radiation sensitivity in breast cancer cells
    Jaime Gomez-Millan
    Department of Radiation Oncology, Radiation and Cancer Biology Laboratory, Indiana University School of Medicine, Indianapolis, IN 46202 5251, USA
    Int J Radiat Oncol Biol Phys 67:897-905. 2007
  9. ncbi request reprint Oligonucleotide N3'-->P5' phosphoramidates as efficient telomerase inhibitors
    Brittney Shea Herbert
    Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas, TX 75390 9039, USA
    Oncogene 21:638-42. 2002
  10. ncbi request reprint Lipid-conjugated telomerase template antagonists sensitize resistant HER2-positive breast cancer cells to trastuzumab
    Erin M Goldblatt
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, 46202 5251, USA
    Breast Cancer Res Treat 118:21-32. 2009

Collaborators

Detail Information

Publications28

  1. ncbi request reprint p16(INK4a) inactivation is not required to immortalize human mammary epithelial cells
    Brittney Shea Herbert
    Department of Cell Biology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas, TX 75390 9039, USA
    Oncogene 21:7897-900. 2002
    ..These findings support the concept that the so-called M0 stage represents a cell culture stress-induced growth arrest and that hTERT is sufficient to immortalize HMECs when cultured under adequate conditions...
  2. ncbi request reprint Telomere dysfunction in aging and cancer
    David Gilley
    Department of Medical and Molecular Genetics, The Indiana University Cancer Center, Indiana University School of Medicine, 975 West Walnut St, IB 242, Indianapolis, IN 46202 5251, USA
    Int J Biochem Cell Biol 37:1000-13. 2005
    ..Herein, we provide an overview of the emerging knowledge of telomere dysfunction and how it relates to possible links between aging and cancer...
  3. ncbi request reprint Nonradioactive detection of telomerase activity using the telomeric repeat amplification protocol
    Brittney Shea Herbert
    Department of Medical and Molecular Genetics, Indiana University Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana 46202 5251, USA
    Nat Protoc 1:1583-90. 2006
    ..These modified TRAP assays can be accomplished within 4 h (from lysis of samples to analysis of telomerase products)...
  4. pmc A molecular signature of normal breast epithelial and stromal cells from Li-Fraumeni syndrome mutation carriers
    Brittney Shea Herbert
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA
    Oncotarget 1:405-22. 2010
    ....
  5. ncbi request reprint Meeting report: second international meeting on quadruplex DNA
    Brittney Shea Herbert
    Dept of Medical and Molecular Genetics, Indiana University Melvin and Bren Simon Cancer Center, Indiana University Center for Regenerative Biology and Medicine, Indiana University School of Medicine, IB 242 Indianapolis, IN 46202, USA
    Biochimie 91:1059-65. 2009
    ..The meeting comprised two Keynote lectures, twenty-three invited talks, and forty-two posters covering various aspects of these topics using a wide variety of technologies...
  6. ncbi request reprint Lipid modification of GRN163, an N3'-->P5' thio-phosphoramidate oligonucleotide, enhances the potency of telomerase inhibition
    Brittney Shea Herbert
    Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9039, USA
    Oncogene 24:5262-8. 2005
    ..These results suggest that the lipid-conjugated thio-phosphoramidates could be important for improved pharmacodynamics of telomerase inhibitors in cancer therapy...
  7. ncbi request reprint Telomerase template antagonist GRN163L disrupts telomere maintenance, tumor growth, and metastasis of breast cancer
    Amelia E Hochreiter
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202 5251, USA
    Clin Cancer Res 12:3184-92. 2006
    ..The aim of this study was to address the breast cancer translational potential of the novel telomerase inhibitor, GRN163L...
  8. ncbi request reprint Specific telomere dysfunction induced by GRN163L increases radiation sensitivity in breast cancer cells
    Jaime Gomez-Millan
    Department of Radiation Oncology, Radiation and Cancer Biology Laboratory, Indiana University School of Medicine, Indianapolis, IN 46202 5251, USA
    Int J Radiat Oncol Biol Phys 67:897-905. 2007
    ..Our goal was to test whether the treatment with GRN163L enhances sensitivity to irradiation (IR) in MDA-MB-231 breast cancer cells...
  9. ncbi request reprint Oligonucleotide N3'-->P5' phosphoramidates as efficient telomerase inhibitors
    Brittney Shea Herbert
    Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas, TX 75390 9039, USA
    Oncogene 21:638-42. 2002
    ..The results suggest that the oligonucleotide N3'-->P5' phosphoramidates, and particularly thio-phosphoramidates, might be further developed as selective anti-telomerase reagents...
  10. ncbi request reprint Lipid-conjugated telomerase template antagonists sensitize resistant HER2-positive breast cancer cells to trastuzumab
    Erin M Goldblatt
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, 46202 5251, USA
    Breast Cancer Res Treat 118:21-32. 2009
    ..These findings implicate that telomerase template antagonists have potential use in the treatment of cancers that have developed resistance to traditional cancer therapy...
  11. ncbi request reprint Telomerase immortalization of human mammary epithelial cells derived from a BRCA2 mutation carrier
    Cheryl M Lewis
    Hamon Center for Therapeutic Oncology Research and Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390 9039, USA
    Breast Cancer Res Treat 99:103-15. 2006
    ....
  12. ncbi request reprint Bypass of telomere-dependent replicative senescence (M1) upon overexpression of Cdk4 in normal human epithelial cells
    Ruben D Ramirez
    Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center, Dallas, TX 75390 8593, USA
    Oncogene 22:433-44. 2003
    ..These results suggest that the differentiation pathways in Cdk4-overexpressing cells remain intact...
  13. ncbi request reprint Shared environmental factors associated with telomere length maintenance in elderly male twins
    Nazmul Huda
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Aging Cell 6:709-13. 2007
    ..0025 and 0.002, respectively). Our results emphasize that shared environmental factors can have a primary impact on telomere length maintenance in elderly humans...
  14. pmc Pharmaceutical regulation of telomerase and its clinical potential
    Alyssa A Sprouse
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Cell Mol Med 16:1-7. 2012
    ..This review will introduce human telomeres and telomerase and discuss pharmacological regulation of telomerase, including telomerase inhibitors and activators, and their use in human diseases...
  15. doi request reprint Analysis of telomeres and telomerase
    Brittney Shea Herbert
    The University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Curr Protoc Cell Biol . 2003
    ..These assays can be used to study the in vitro cellular effects of aging and cancer treatments on telomere biology and telomerase activity...
  16. ncbi request reprint A peroxisome proliferator-activated receptor-gamma agonist and the p53 rescue drug CP-31398 inhibit the spontaneous immortalization of breast epithelial cells
    Brittney Shea Herbert
    Department of Cell Biology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9039, USA
    Cancer Res 63:1914-9. 2003
    ....
  17. doi request reprint The telomerase template antagonist GRN163L alters MDA-MB-231 breast cancer cell morphology, inhibits growth, and augments the effects of paclitaxel
    Erin M Goldblatt
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202 5251, USA
    Mol Cancer Ther 8:2027-35. 2009
    ..These data support a rationale for potentially combining GRN163L with paclitaxel for the treatment of breast cancer in the clinical setting...
  18. pmc Immortalization and characterization of osteoblast cell lines generated from wild-type and Nmp4-null mouse bone marrow stromal cells using murine telomerase reverse transcriptase (mTERT)
    Marta B Alvarez
    Department of Anatomy and Cell Biology, Indiana University School of Medicine IUSM, Indianapolis, IN 46202, USA
    J Cell Physiol 227:1873-82. 2012
    ..These immortalized cell lines will provide a valuable tool for disentangling the complex functional roles underlying Nmp4/CIZ regulation of bone anabolism...
  19. doi request reprint Medical genetics and epigenetics of telomerase
    Jillian E Koziel
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA
    J Cell Mol Med 15:457-67. 2011
    ..Continual investigation of the complex regulation of telomerase will further our insight into the use of controlling telomerase activity in medicine...
  20. ncbi request reprint Factors impacting human telomere homeostasis and age-related disease
    David Gilley
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, United States
    Mech Ageing Dev 129:27-34. 2008
    ....
  21. pmc A telomerase immortalized human proximal tubule cell line with a truncation mutation (Q4004X) in polycystin-1
    Brittney Shea Herbert
    Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, United States of America
    PLoS ONE 8:e55191. 2013
    ..Nephron segment specific markers suggest a proximal tubule origin for these cells and the cell line will be useful to study mechanistic details of cyst formation in proximal tubule cells...
  22. ncbi request reprint p53 Modulates Hsp90 ATPase Activity and Regulates Aryl Hydrocarbon Receptor Signaling
    Amit Kochhar
    Authors Affiliations Department of Medicine, Weill Cornell Medical College Department of Basic Sciences, College of Dentistry and Department of Environmental Medicine, School of Medicine, New York University, New York Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland and Department of Medical and Molecular Genetics, Indiana University Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IndianaAuthors Affiliations Department of Medicine, Weill Cornell Medical College Department of Basic Sciences, College of Dentistry and Department of Environmental Medicine, School of Medicine, New York University, New York Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland and Department of Medical and Molecular Genetics, Indiana University Simon Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana
    Cancer Prev Res (Phila) 7:596-606. 2014
    ..Collectively, our results suggest that p53 affects AhR-dependent gene expression, PAH metabolism, and possibly carcinogenesis. Cancer Prev Res; 7(6); 596-606. ©2014 AACR. ..
  23. pmc A cancer-associated PCNA expressed in breast cancer has implications as a potential biomarker
    Linda H Malkas
    Division of Hematology and Oncology, Indiana University School of Medicine, and Indiana Cancer Center, Indianapolis, IN 46202, USA
    Proc Natl Acad Sci U S A 103:19472-7. 2006
    ..Our studies indicate that the caPCNA isoform may be a previously uncharacterized detector of breast cancer...
  24. ncbi request reprint Aneuploidy and telomere attrition are independent determinants of crisis in SV40-transformed epithelial cells
    Mihaela Velicescu
    University of Southern California Norris Comprehensive Cancer Center, Department of Pathology, University of Southern California, Keck School of Medicine, Los Angeles, California 90089 9181, USA
    Cancer Res 63:5813-20. 2003
    ..Reestablishment or emergence of ploidy stability, which is not always dependent on telomerase activation, is necessary for acquisition of the potential to achieve replicative immortality...
  25. ncbi request reprint Novel short oligonucleotide conjugates as inhibitors of human telomerase
    Krisztina Pongracz
    Geron Corporation, Menlo Park, California 94025, USA
    Nucleosides Nucleotides Nucleic Acids 22:1627-9. 2003
    ....
  26. ncbi request reprint Small molecule, oligonucleotide-based telomerase template inhibition in combination with cytolytic therapy in an in vitro androgen-independent prostate cancer model
    Benjamin K Canales
    Department of Urology, University of Minnesota, Minneapolis, MN 55455, USA
    Urol Oncol 24:141-51. 2006
    ..Determine the efficacy and timing of small molecule oligonucleotide-based inhibitors to the enzyme telomerase in an in vitro model of androgen-independent, osseous prostate cancer...
  27. ncbi request reprint Disparate effects of telomere attrition on gene expression during replicative senescence of human mammary epithelial cells cultured under different conditions
    Hong Zhang
    Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305 5120, USA
    Oncogene 23:6193-8. 2004
    ....
  28. ncbi request reprint Oligonucleotide conjugate GRN163L targeting human telomerase as potential anticancer and antimetastatic agent
    Sergei M Gryaznov
    Geron Corporation, 230 Constitution Drive, Menlo Park, CA 94025, USA
    Nucleosides Nucleotides Nucleic Acids 26:1577-9. 2007
    ..GRN163L is currently in Phase I and Phase I/II clinical studies in patients with solid tumors and CLL, respectively...