K S Hall

..To examine the relationship between level of education and childhood rural residence as possible risk factors for AD in African Americans in Indianapolis...

..To examine the relationship between cholesterol and other lipids, APOE genotype, and risk of Alzheimer disease (AD) in a population-based study of elderly Yoruba living in Ibadan, Nigeria...

..This study compares age-specific and overall prevalence rates for dementia and Alzheimer's disease (AD) in two nonoverlapping, population-based cohorts of elderly African Americans in Indianapolis in 2001 and 1992...

..We report the results from a 3-year prospective study on the association of statin use on cognitive decline and incident dementia in elderly African Americans...

..Assessing function is a crucial element in the diagnosis of dementia. This information is usually obtained from key informants. However, reliable informants are not always available...

..If populations were identified with significantly lower or higher incidence rates of AD, the search for risk factors in the genesis of AD could be greatly enhanced...

..These estimators are illustrated using data from an Alzheimer's disease study in two populations...

..We apply the above method to data collected in the Indianapolis-Ibadan Dementia Study to estimate the odds ratio for smoking adjusting for misclassification error...

..The epidemiology and natural history of cognitive impairment that is not dementia is important to the understanding of normal aging and dementia...

..Exchange visits have been needed to address data management issues and resolve unexpected problems. The data management on cross-cultural studies can be handled successfully, given careful planning...

..This study is the first to demonstrate the clinical utility of the CERAD neuropsychological battery in the differential diagnosis of memory disorders of the aged in a non-North-American sample...

..Our preliminary results suggest that African populations are less vulnerable to chemical-induced oxidative DNA damage...

..Newer risk factors have been identified for cardiovascular disease, but these have been rarely examined in elderly populations and not those of developing countries...

..Anticholinergic properties of certain medications often go unrecognized, and are frequently used by the elderly population. Few studies have yet defined the long-term impact of these medications on the incidence of cognitive impairment...

..We conclude that Stick Design is a reasonable test of visuoconstructional ability in older cohorts with very limited educational exposure and literacy...

..Limited data exist on the impact of dementia in developing nations, including its association with mortality...

..Corresponding analysis using blood pressure measurements on the subset of participants was inconclusive. CONCLUSION: Antihypertensive medication use is associated with preservation of cognitive function in older African American adults...

..The relationship between trace elements measured in individual biological samples and cognitive function in an elderly population had not been investigated extensively...

..Factors contributing to this longitudinal variability in outcomes are reviewed, including the role of medical health factors. The review closes with suggestions for next steps in the epidemiological research of mild cognitive impairment...

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..To evaluate the association between histamine-2 receptor antagonist (H2A) exposure and incident cognitive impairment in a community-based sample of African Americans...

..This is a community-based longitudinal epidemiological comparative study of elderly African Americans in Indianapolis and elderly Yoruba in Ibadan, Nigeria...

..Results in this geographically stable cohort support the hypothesis that a lifelong low selenium level is associated with lower cognitive function...

..We eventually hope to create a risk factor model that will not only account for the dementia rate differences between Yoruba and African Americans, but also help explain dementia rates in other developing and developed countries...

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..71; 95% CI: 0.45-1.10; p = 0.1238), Ibadan subjects under 75 (hazard ratio: 1.04; 95% CI: 0.78 to 1.40; p = 0.7782), or Ibadan subjects over 75 (hazard ratio: 1.21; 95% CI: 0.83 to 1.75; p = 0.3274)...

..Identification of genetic risk factors in African Americans is essential for understanding the etiology of AD...

..The Neuropsychiatric Inventory (NPI) has been used to assess behavioral symptoms of dementia in the United States, Taiwan, Japan, and Italy...

..To describe the construction of a disease model incorporating both genetic an environmental factors in the etiology of Alzheimer's disease (AD), using data generated from the Indianapolis-Ibadan dementia project (I-IDP)...

..This lack of association in the Yoruba might reflect genetic variation, environmental factors, as well as genetic/environmental interactions...

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..Specific Aim 4: To examine the interaction between indices of social involvement and their change over time with the risk of cognitive decline in the African Americans and the Yoruba. ..

..Specific Aim 4: To examine the interaction between indices of social involvement and their change over time with the risk of cognitive decline in the African Americans and the Yoruba. ..

..Specific Aim 4: To examine the interaction between indices of social involvement and their change over time with the risk of cognitive decline in the African Americans and the Yoruba. ..