SAMIR KUMAR contact GUPTA

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. ncbi request reprint Prevalence of proteinuria and the development of chronic kidney disease in HIV-infected patients
    S K Gupta
    Division of Infectious Diseases, Indiana University School of Medicine, Wishard Hospital, Indianapolis, IN 46202, USA
    Clin Nephrol 61:1-6. 2004
  2. pmc Pentoxifylline, inflammation, and endothelial function in HIV-infected persons: a randomized, placebo-controlled trial
    Samir K Gupta
    Division of Infectious Diseases, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
    PLoS ONE 8:e60852. 2013
  3. pmc Worsening endothelial function with efavirenz compared to protease inhibitors: a 12-month prospective study
    Samir K Gupta
    Division of Infectious Diseases, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    PLoS ONE 7:e45716. 2012
  4. pmc The pharmacokinetics and pharmacogenomics of efavirenz and lopinavir/ritonavir in HIV-infected persons requiring hemodialysis
    Samir K Gupta
    Indiana University School of Medicine, Indianapolis, Indiana, USA
    AIDS 22:1919-27. 2008
  5. pmc The effects of HIV type-1 viral suppression and non-viral factors on quantitative proteinuria in the highly active antiretroviral therapy era
    Samir K Gupta
    Division of Infectious Diseases, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Antivir Ther 14:543-9. 2009
  6. pmc Proteinuria, creatinine clearance, and immune activation in antiretroviral-naive HIV-infected subjects
    Samir K Gupta
    Indiana University School of Medicine, Wishard Hospital, Indianapolis, IN 46202, USA
    J Infect Dis 200:614-8. 2009
  7. pmc Anti-inflammatory treatment with pentoxifylline improves HIV-related endothelial dysfunction: a pilot study
    Samir K Gupta
    Department of Medicine, Indiana Center for Vascular Biology and Medicine, Indiana University School of Medicine, Indianapolis, USA
    AIDS 24:1377-80. 2010
  8. pmc Endothelial, inflammatory, coagulation, metabolic effects and safety of etravirine in HIV-uninfected volunteers
    Samir K Gupta
    Division of Infectious Diseases, Indiana University School of Medicine, Indianapolis, USA
    AIDS Patient Care STDS 25:327-31. 2011
  9. pmc Reduced renal function is associated with progression to AIDS but not with overall mortality in HIV-infected Kenyan adults not initially requiring combination antiretroviral therapy
    Samir K Gupta
    Division of Infectious Diseases, Indiana University School of Medicine, Indianapolis, IN, USA
    J Int AIDS Soc 14:31. 2011
  10. pmc Neither proteinuria nor albuminuria is associated with endothelial dysfunction in HIV-infected patients without diabetes or hypertension
    Samir K Gupta
    Division of Infectious Diseases, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Infect Dis 204:1946-50. 2011

Research Grants

  1. HIV-Related Proteinuria and Endothelial Dysfunction
    Samir Gupta; Fiscal Year: 2007
  2. HIV, Inflammation, and Endothelial Dysfunction
    SAMIR KUMAR contact GUPTA; Fiscal Year: 2010

Detail Information

Publications25

  1. ncbi request reprint Prevalence of proteinuria and the development of chronic kidney disease in HIV-infected patients
    S K Gupta
    Division of Infectious Diseases, Indiana University School of Medicine, Wishard Hospital, Indianapolis, IN 46202, USA
    Clin Nephrol 61:1-6. 2004
    ....
  2. pmc Pentoxifylline, inflammation, and endothelial function in HIV-infected persons: a randomized, placebo-controlled trial
    Samir K Gupta
    Division of Infectious Diseases, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
    PLoS ONE 8:e60852. 2013
    ..Our preliminary in vitro and in vivo research suggests that pentoxifylline (PTX) reduces vascular inflammation and improves endothelial function in HIV-infected persons not requiring antiretroviral therapy...
  3. pmc Worsening endothelial function with efavirenz compared to protease inhibitors: a 12-month prospective study
    Samir K Gupta
    Division of Infectious Diseases, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    PLoS ONE 7:e45716. 2012
    ....
  4. pmc The pharmacokinetics and pharmacogenomics of efavirenz and lopinavir/ritonavir in HIV-infected persons requiring hemodialysis
    Samir K Gupta
    Indiana University School of Medicine, Indianapolis, Indiana, USA
    AIDS 22:1919-27. 2008
    ..To evaluate the pharmacokinetics and pharmacogenomics of efavirenz (EFV) and lopinavir/ritonavir (LPV/RTV) in HIV-infected persons requiring hemodialysis...
  5. pmc The effects of HIV type-1 viral suppression and non-viral factors on quantitative proteinuria in the highly active antiretroviral therapy era
    Samir K Gupta
    Division of Infectious Diseases, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Antivir Ther 14:543-9. 2009
    ..Proteinuria is associated with progressive renal disease and overall mortality in HIV-infected patients; however, the prevalence and correlates of quantitative proteinuria in the highly active antiretroviral therapy era are unknown...
  6. pmc Proteinuria, creatinine clearance, and immune activation in antiretroviral-naive HIV-infected subjects
    Samir K Gupta
    Indiana University School of Medicine, Wishard Hospital, Indianapolis, IN 46202, USA
    J Infect Dis 200:614-8. 2009
    ..50%; P=.01), with even more pronounced differences noted among men and among blacks and Hispanics. Proteinuria may be a surrogate measurement of greater immune activation in HIV-infected patients initiating antiretroviral therapy...
  7. pmc Anti-inflammatory treatment with pentoxifylline improves HIV-related endothelial dysfunction: a pilot study
    Samir K Gupta
    Department of Medicine, Indiana Center for Vascular Biology and Medicine, Indiana University School of Medicine, Indianapolis, USA
    AIDS 24:1377-80. 2010
    ..Pentoxifylline may reverse HIV-related endothelial dysfunction by directly inhibiting the endothelial leukocyte adhesion pathway...
  8. pmc Endothelial, inflammatory, coagulation, metabolic effects and safety of etravirine in HIV-uninfected volunteers
    Samir K Gupta
    Division of Infectious Diseases, Indiana University School of Medicine, Indianapolis, USA
    AIDS Patient Care STDS 25:327-31. 2011
    ..ETR was generally well tolerated. Larger studies are warranted to confirm that ETR can be used safely as part of HIV postexposure prophylaxis regimens...
  9. pmc Reduced renal function is associated with progression to AIDS but not with overall mortality in HIV-infected Kenyan adults not initially requiring combination antiretroviral therapy
    Samir K Gupta
    Division of Infectious Diseases, Indiana University School of Medicine, Indianapolis, IN, USA
    J Int AIDS Soc 14:31. 2011
    ..Renal disease has been identified as a risk factor for disease progression or death in some populations...
  10. pmc Neither proteinuria nor albuminuria is associated with endothelial dysfunction in HIV-infected patients without diabetes or hypertension
    Samir K Gupta
    Division of Infectious Diseases, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Infect Dis 204:1946-50. 2011
    ..None of the renal markers, modeled as either continuous or categorical variables, correlated with FMD. Contrary to expectations, endothelial dysfunction may not be the link between nephropathy and CVD in HIV...
  11. doi request reprint Tenofovir-associated Fanconi syndrome: review of the FDA adverse event reporting system
    Samir K Gupta
    Division of Infectious Diseases, Indiana University School of Medicine, Indianapolis, Indiana, USA
    AIDS Patient Care STDS 22:99-103. 2008
    ..Although reporting biases and the exclusion of reports with serious confounding conditions likely affected the estimation of outcomes in this case series, severe complications of tenofovir-associated Fanconi syndrome were uncommon...
  12. ncbi request reprint Evaluation of the Winthrop-University Hospital criteria to identify Legionella pneumonia
    S K Gupta
    Division of Infectious Diseases, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Chest 120:1064-71. 2001
    ....
  13. ncbi request reprint The role of atypical pathogens in community-acquired pneumonia
    S K Gupta
    Division of Infectious Diseases, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Med Clin North Am 85:1349-65, vii. 2001
    ..Etiologic diagnosis is still difficult, although new methods are becoming available. This article focuses on these issues and on why the term atypical is no longer meaningful...
  14. ncbi request reprint Exogenous cushing syndrome mimicking human immunodeficiency virus lipodystrophy
    Samir K Gupta
    Division of Infectious Diseases, Indiana University School of Medicine, Wishard Memorial Hospital, Indianapolis, IN, 46202, USA
    Clin Infect Dis 35:E69-71. 2002
    ..Clinicians should be aware that clinical clues may indicate conditions other than lipodystrophy that may cause abnormal fat accumulation and that fluticasone should be cautiously administered to patients who are receiving ritonavir...
  15. ncbi request reprint Guidelines for the management of chronic kidney disease in HIV-infected patients: recommendations of the HIV Medicine Association of the Infectious Diseases Society of America
    Samir K Gupta
    Division of Infectious Diseases, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Clin Infect Dis 40:1559-85. 2005
  16. pmc The effects of highly active antiretroviral therapy on albuminuria in HIV-infected persons: results from a randomized trial
    Samir K Gupta
    Division of Infectious Diseases, Indiana University School of Medicine, Wishard Hospital, OPW 430, 1001 W 10th Street, Indianapolis, IN 46202, USA
    Nephrol Dial Transplant 20:2237-42. 2005
    ..Alternatively, albuminuria may improve with HAART as a result of treating renal parenchymal HIV infection. Longitudinal studies have not been performed previously addressing the effects of HAART on albuminuria...
  17. ncbi request reprint Tenofovir and changes in renal function
    Samir K Gupta
    Clin Infect Dis 41:570-1; author reply 571. 2005
  18. doi request reprint Will there be an epidemic of HIV-related chronic kidney disease in sub-Saharan Africa? Too soon to tell
    Kara K Wools-Kaloustian
    Division of Infectious Diseases, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Kidney Int 74:845-7. 2008
    ..However, the greatest population at risk resides in resource-limited areas where monitoring and treatment for kidney dysfunction are outside the scope of medical practice. More epidemiologic and prevention research is sorely needed...
  19. pmc Proteinuria and endothelial dysfunction in stable HIV-infected patients. A pilot study
    Samir K Gupta
    J Acquir Immune Defic Syndr 45:596-8. 2007
  20. doi request reprint Improvement in HIV-related endothelial dysfunction using the anti-inflammatory agent salsalate: a pilot study
    Samir K Gupta
    Indiana University School of Medicine, Indianapolis, Indiana, USA
    AIDS 22:653-5. 2008
    ..However, hepatotoxicity occurred frequently. Research using alternative agents is warranted to examine the role of inflammation in HIV-related cardiovascular disease...
  21. ncbi request reprint The clinical epidemiology and course of the spectrum of renal diseases associated with HIV infection
    Lynda Anne Szczech
    Division of Nephrology, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Kidney Int 66:1145-52. 2004
    ..This study was undertaken to compare HIVAN to the spectrum of other kidney diseases seen among HIV-infected patients...
  22. pmc Suppression of HIV-1 replication by antiretroviral therapy improves renal function in persons with low CD4 cell counts and chronic kidney disease
    Robert C Kalayjian
    Department of Medicine, MetroHealth Medical Center, Cleveland, Ohio, USA
    AIDS 22:481-7. 2008
    ..To examine the association between changes in glomerular filtration rates (GFR) and antiretroviral therapy (ART)-mediated suppression of plasma HIV-1 viremia...
  23. ncbi request reprint Single-dose pharmacokinetics and safety of pegylated interferon-alpha2b in patients with chronic renal dysfunction
    Samir K Gupta
    Schering Plough Research Institute, Kenilworth, New Jersey 07033, USA
    J Clin Pharmacol 42:1109-15. 2002
    ..Based on the relationship between PEG-Intron apparent clearance and CL(CR), renal clearance accountsfor less than half of its total clearance. Hemodialysis did not affect PEG-Intron apparent clearance...
  24. ncbi request reprint The effect of multiple doses of peginterferon alfa-2b on the steady-state pharmacokinetics of methadone in patients with chronic hepatitis C undergoing methadone maintenance therapy
    Samir K Gupta
    MBA, Schering Plough Research Institute K15 22745, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
    J Clin Pharmacol 47:604-12. 2007
    ....
  25. ncbi request reprint Renal disease in an antiretroviral-naïve HIV-infected outpatient population in Western Kenya
    Kara Wools-Kaloustian
    Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Nephrol Dial Transplant 22:2208-12. 2007
    ....

Research Grants4

  1. HIV-Related Proteinuria and Endothelial Dysfunction
    Samir Gupta; Fiscal Year: 2007
    ..Dub6) in the fields of HIV metabolic and renal complications, renal vascular and glomerular pathology, and clinical trials design and implementation. ..
  2. HIV, Inflammation, and Endothelial Dysfunction
    SAMIR KUMAR contact GUPTA; Fiscal Year: 2010
    ..End of Abstract) ..